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TDMS Study 05217-05 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                        T-BUTYLHYDROQUINONE


NTP Experiment-Test: 05217-05                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: DOSED FEED                                                                                                 Time: 19:29:54


                                                       2 YEAR CORE STUDY


       Facility:  Southern Research Institute

       Chemical CAS #:  1948-33-0

       Lock Date:  08/04/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    UNTREATDCONTROL
                               Include 004    0.125%
                               Include 006    0.25%
                               Include 008    0.5%
                               Include 001    UNTREATDCONTROL
                               Include 003    0.125%
                               Include 005    0.25%
                               Include 007    0.5%

























                                                             Page   1
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|             
                                           | 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                    2                     |             
      Inflammation, Chronic, Focal         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |             3                                      2                     |             
      Eosinophilic Focus                   |                                                                2  1      |             
      Eosinophilic Focus, Multiple         | 2                          2                    2                        |             
      Fatty Change, Focal                  |                                                                          |             
      Fatty Change                         | 1                                                  3                 3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Focal                  |    1                                                              2      |             
      Mixed Cell Focus                     |                                           4                              |             
      Necrosis, Focal                      |                               3                                          |             
      Thrombosis                           |                                                          3               |             
      Bile Duct, Cyst                      |                                                                          |             
      Centrilobular, Necrosis              |                                                          4               |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +              +                 +                                    |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        | 2  3                                1                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                   1                                1                     |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                    1                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|             
                                           | 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            1  1                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Pars Distalis, Angiectasis           |                2                                                         |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                     2                 1                  |             
      Pars Distalis, Hyperplasia, Focal    |    2                                            2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          |       2                                                                  |             
      Inflammation, Chronic, Focal         |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |                      2  1           2     2     1           1  3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |       3        3                 3  4        2              2            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |          2  3           3  3                 3  4     4     4            |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  2  3  3  3  3  3  3  3  2  3  3  3  3     3  2  3  3  3  3  3  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                                   2      |             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +           +     +                                    |             
      Hyperplasia, Cystic                  |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|             
                                           | 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Hemorrhage                    |                               3                                          |             
      Iliac, Hyperplasia                   |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Renal, Hemorrhage                    |                               2                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               3                                          |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                   3      |             
      Hyperplasia, Lymphoid                |                            3                                      3      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   2           3     2                    3     3  2  2   |             
      Hyperplasia, Lymphoid                |                            3        2                                    |             
      Necrosis, Focal                      |                               3                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  I  +  +  +  +  +  +  M|             
      Hyperplasia, Histiocytic             |                                                                   3      |             
      Hyperplasia, Lymphoid                |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 2              2                                   2                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       | 4                                                  4                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                  +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         3|             
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |             
      Interstitium, Inflammation,          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|             
                                           | 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Glands, Dilatation, Focal    |       3  1  1           2  2        2  2        2              2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                3         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 1  1     1        1  1     1     1  1     2  1  1  1  1        2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                        1            |             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                  2                                      2|             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Fatty Change, Focal                  |                1                    3                                    |             
      Fatty Change                         |       4                                                                  |             
      Hematopoietic Cell Proliferation     |                      1                    3  2                           |             
      Infarct                              |                                                          2               |             
      Infiltration Cellular, Mixed Cell    |                                           3  2                           |             
      Inflammation, Focal                  |                1                                                         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Cyst                      | 1                                                                        |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                    +  +  +              +        +      |             
      Inflammation, Chronic                |                                           4                              |             
      Fat, Necrosis                        |                1                    3  2                 3        3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |                                                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                     1           1                        |             
      Inflammation, Chronic                |       2                                         1                        |             
      Ulcer                                |       2                                                                  |             
      Epithelium, Hyperplasia              |       2                                         1           1            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cytoplasmic Alteration, Focal        |                   1                                                      |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Capsule, Hyperplasia                 |                         2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          |                                                                          |             
      Inflammation, Chronic, Focal         |                               1                                          |             
      C-Cell, Hyperplasia                  |                                                          1        3      |             
      Follicular Cell, Hyperplasia         | 3        1                 2                                1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3     3                                                               |             
      Cyst                                 |          3        2              3  2     3     2  3        3        4   |             
      Hemorrhage                           |                                                          2               |             
      Inflammation, Suppurative            |                                           4  4                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |             3                                3     3              3      |             
      Inflammation, Suppurative            |                      3  3                 3                              |             
      Endometrium, Hyperplasia, Cystic     | 4  4  2  3  3  4  3  3  3  3  3  3  3  3  4  3  4  3  3  3  3  4  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia                          |                      3                    3                              |             
      Myelofibrosis                        |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +              +     +              +               |             
      Hyperplasia, Cystic                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia                   |                      2              2                                    |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                          2               |             
      Mediastinal, Hyperplasia             |                                           3                              |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia                   |                                           4              2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                         1                                                |             
      Hematopoietic Cell Proliferation     |                         3                                                |             
      Hemorrhage                           |                         2                                                |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                | 2                          2     3                                      3|             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      3  2     4     3     4  3                           |             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Inflammation, Suppurative            |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                            2                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation,          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |                                           2  2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Glands, Dilatation, Focal    | 2           2  2           1                                2     2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          2               |             
      Inflammation, Chronic                |                                           3  2                           |             
      Nephropathy                          | 1  1        1  1     1     1  1        2        1  2  1  1  1  1        1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    UNTREATD                               | 0|                                                                       |      L     |
    CONTROL                                | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  51        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     |                                                                          |      2  2.5|
      Eosinophilic Focus                   |                                                                          |      4  1.8|
      Eosinophilic Focus, Multiple         |                                                                          |      3  2.0|
      Fatty Change, Focal                  |                                                                          |      2  2.0|
      Fatty Change                         |                                                                          |      4  2.8|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.5|
      Inflammation, Focal                  |                                                                          |      3  1.3|
      Mixed Cell Focus                     |                                                                          |      1  4.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Bile Duct, Cyst                      |                                                                          |      1  1.0|
      Centrilobular, Necrosis              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  10        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      8  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Duct, Cyst                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Erosion                              | 1                                                                        |      3  1.0|
      Inflammation, Chronic                | 1                                                                        |      5  1.2|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              | 1                                                                        |      5  1.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Erosion                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    UNTREATD                               | 0|                                                                       |      L     |
    CONTROL                                | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2  1.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  49        |
      Angiectasis                          |                                                                          |      2  1.5|
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      2  1.5|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Degeneration, Cystic, Focal          |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |                                                                          |      2  2.0|
      Follicular Cell, Hyperplasia         | 2                                                                        |     12  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  50        |
      Angiectasis                          |                                                                          |      2  3.0|
      Cyst                                 |                                                                          |     15  2.8|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Hydrometra                           | 2                                                                        |     13  3.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    UNTREATD                               | 0|                                                                       |      L     |
    CONTROL                                | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      3  3.0|
      Endometrium, Hyperplasia, Cystic     | 2                                                                        |     50  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  3.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   7        |
      Hyperplasia, Cystic                  |                                                                          |      1  4.0|
      Iliac, Hemorrhage                    |                                                                          |      1  3.0|
      Iliac, Hyperplasia                   |                                                                          |      2  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Hyperplasia                   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  50        |
      Amyloid Deposition                   |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.7|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Hematopoietic Cell Proliferation     | 2                                                                        |     14  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.7|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  45        |
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
      Ectasia                              |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    UNTREATD                               | 0|                                                                       |      L     |
    CONTROL                                | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Atrophy, Focal                       |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Congestion                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Interstitium, Inflammation,          |                                                                          |            |
          Suppurative                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Mucosa, Glands, Dilatation, Focal    | 2                                                                        |     16  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Nephropathy                          | 2                                                                        |     30  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 9|             
                                           | 4| 5| 4| 2| 4| 4| 4| 7| 4| 5| 5| 6| 5| 5| 8| 6| 6| 4| 6| 5| 6| 6| 5| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.125%                                 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                              1                 1     2   |             
      Eosinophilic Focus, Multiple         |                2  3        3        3                                    |             
      Fatty Change                         |                      3                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Focal                  |                                                                      1   |             
      Mixed Cell Focus                     |                                                          3        4      |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +     +     +     +              +        +        +      |             
      Hemorrhage                           |                                                          3               |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        | 1                                3              4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Pigmentation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +           +                                       |             
      Incisor, Dysplasia                   |                      1           1                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         1                                               2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |          3                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 9|             
                                           | 4| 5| 4| 2| 4| 4| 4| 7| 4| 5| 5| 6| 5| 5| 8| 6| 6| 4| 6| 5| 6| 6| 5| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.125%                                 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                2         |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Intermedia, Hyperplasia, Focal  |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 1              2        3  2  3     2           1  2        1     1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    3                             3                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Cyst                                 |    4        3  2        4                             3           2     2|             
      Inflammation, Suppurative            |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                             3            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            3                                             |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |    3              3                                         3  3  3      |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  3  3  3  2  3  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +              +     +                             +        +      |             
      Iliac, Hyperplasia                   |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         2                    2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Hemorrhage                           |                                              3                           |             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         3                                                |             
      Hematopoietic Cell Proliferation     | 2     3  3  2                          3                                 |             
      Hyperplasia, Lymphoid                |                         2              2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 9|             
                                           | 4| 5| 4| 2| 4| 4| 4| 7| 4| 5| 5| 6| 5| 5| 8| 6| 6| 4| 6| 5| 6| 6| 5| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.125%                                 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                           2                              |             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic, Focal                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                         3     2           4                              |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                           +                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +                             +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Glands, Dilatation, Focal    |       1  2              2  2  2        2  1  2  1     2     2  1  1      |             
      Nasolacrimal Duct, Cyst              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Nephropathy                          | 1  1     1  1     2  2  1           1  1  1     1  1  1              1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 1| 2| 3| 3| 5| 3| 3| 6| 0| 3| 3| 3|             
                                           | 8| 5| 5| 5| 5| 3| 4| 6| 6| 6| 4| 6| 9| 0| 9| 6| 5| 4| 4| 5| 5| 3| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.125%                                 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          2                                                               |             
      Eosinophilic Focus                   |       2                                   1  1        2  3               |             
      Eosinophilic Focus, Multiple         |                                                                      2   |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                3         |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Mixed Cell Focus                     |                      4                                                   |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                             +        +        +                        |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                        2        3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Pigmentation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Dysplasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 1  2                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  M  +  M  +  +  +  I  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 1| 2| 3| 3| 5| 3| 3| 6| 0| 3| 3| 3|             
                                           | 8| 5| 5| 5| 5| 3| 4| 6| 6| 6| 4| 6| 9| 0| 9| 6| 5| 4| 4| 5| 5| 3| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.125%                                 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |             1     2                                                      |             
      Pars Distalis, Hyperplasia, Focal    |                                        1        2                    2   |             
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1  1  1        1        1                 1  1                       1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                  3  3                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                                  2                                       |             
      Cyst                                 |             3           3                                      3         |             
      Inflammation, Suppurative            |                                                                4         |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                         4|             
      Hydrometra                           |    3     3     3  2                                3                    4|             
      Hyperplasia, Focal, Histiocytic      |                                                                      2   |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3  3  3  3  3  3  3  2  2  4  3  3  3  3  3  3  2  2  3  4  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                              +         |             
      Iliac, Hyperplasia                   |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Renal, Hyperplasia                   |                                                                4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                3         |             
      Hyperplasia, Lymphoid                |             2                                                     3      |             
      Hyperplasia                          |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |    3     2     3                    3  2  2                    3        3|             
      Hyperplasia, Lymphoid                |    2  3     3                                         2           3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 1| 2| 3| 3| 5| 3| 3| 6| 0| 3| 3| 3|             
                                           | 8| 5| 5| 5| 5| 3| 4| 6| 6| 6| 4| 6| 9| 0| 9| 6| 5| 4| 4| 5| 5| 3| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.125%                                 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema           |                                                    2                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic, Focal                  |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Inflammation, Suppurative            |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                   3      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                           +                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               1                                          |             
      Mucosa, Glands, Dilatation, Focal    |    1  1  1  1  2  2     2  1     1           2  2     1  1              1|             
      Nasolacrimal Duct, Cyst              |                               1                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Nephropathy                          | 1  1  2  2     1  1  1  1  1     1        1  1  1     2           1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6|                                                                    |            |
                             DAY ON TEST   | 3| 1|                                                                    |            |
                                           | 4| 2|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 3| 3|                                                                    |      A     |
    0.125%                                 | 5| 6|                                                                    |      L     |
                                           | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +                                                                     |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +                                                                     |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +                                                                     |  52        |
      Basophilic Focus                     |                                                                          |      1  2.0|
      Eosinophilic Focus                   | 2                                                                        |      9  1.7|
      Eosinophilic Focus, Multiple         |                                                                          |      5  2.6|
      Fatty Change                         |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |    3                                                                     |      1  3.0|
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      3  3.7|
      Necrosis, Focal                      |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |  13        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |    3                                                                     |      1  3.0|
      Fat, Necrosis                        |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                                                                     |  52        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                                                                     |  52        |
      Erosion                              |    2                                                                     |      1  2.0|
      Pigmentation, Focal                  |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Incisor, Dysplasia                   |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |  52        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +                                                                     |  51        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6|                                                                    |            |
                             DAY ON TEST   | 3| 1|                                                                    |            |
                                           | 4| 2|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 3| 3|                                                                    |      A     |
    0.125%                                 | 5| 6|                                                                    |      L     |
                                           | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +                                                                     |  49        |
      Cyst                                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M                                                                     |  44        |
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      3  1.7|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      3  1.7|
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                                                                     |  51        |
      Follicular Cell, Hyperplasia         |                                                                          |     19  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +                                                                     |  52        |
      Degeneration, Cystic                 |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +                                                                     |  49        |
      Angiectasis                          |                                                                          |      2  2.0|
      Cyst                                 |                                                                          |     10  2.9|
      Inflammation, Suppurative            |    4                                                                     |      2  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +                                                                     |  52        |
      Cyst                                 |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrometra                           |                                                                          |     11  3.0|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 4  3                                                                     |     52  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   8        |
      Iliac, Hyperplasia                   |    3                                                                     |      1  3.0|
      Mediastinal, Hyperplasia             |    3                                                                     |      1  3.0|
      Renal, Hyperplasia                   |    4                                                                     |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +                                                                     |  52        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                                                                     |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6|                                                                    |            |
                             DAY ON TEST   | 3| 1|                                                                    |            |
                                           | 4| 2|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 3| 3|                                                                    |      A     |
    0.125%                                 | 5| 6|                                                                    |      L     |
                                           | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Hyperplasia                          |    3                                                                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                                                                     |  52        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    4                                                                     |     14  2.7|
      Hyperplasia, Lymphoid                | 2                                                                        |      8  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +                                                                     |  51        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +                                                                     |  51        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |  52        |
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic, Focal                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |  52        |
      Atrophy, Focal                       |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |  52        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |  52        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mucosa, Glands, Dilatation, Focal    |                                                                          |     27  1.5|
      Nasolacrimal Duct, Cyst              |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6|                                                                    |            |
                             DAY ON TEST   | 3| 1|                                                                    |            |
                                           | 4| 2|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 3| 3|                                                                    |      A     |
    0.125%                                 | 5| 6|                                                                    |      L     |
                                           | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                                                                     |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                                                                     |  52        |
      Congestion                           |    2                                                                     |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Nephropathy                          | 2  2                                                                     |     32  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                                                                     |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Cyst                                 |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Perforation, Chronic                 |                                                                         3|             
      Peyer's Patch, Hyperplasia, Lymphoid |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |             2                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                     2                                    |             
      Eosinophilic Focus                   |    2  2  1                          1        2              2            |             
      Eosinophilic Focus, Multiple         |             3                                                            |             
      Fatty Change, Focal                  |          2                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                    4                     |             
      Inflammation, Focal                  |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Centrilobular, Necrosis              |                                                       3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +     +              +     +|             
      Inflammation, Chronic                |                                                    3                    3|             
      Fat, Necrosis                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                1        2                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                                       3                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Glands, Degeneration, Cystic, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +              +                                                   |             
      Incisor, Dysplasia                   |       2              1                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                         3|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation, Chronic        |                         1                                               2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  I  +  +|             
      Angiectasis                          |       1  1                                                               |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                2  2                                                      |             
      Pars Distalis, Hyperplasia, Focal    | 2                                                     2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                         2|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |    2  1  1  3  2                 1     3              2  1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                3         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 | 2     3              3                 2                    3            |             
      Inflammation, Suppurative            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |          3  3     2        2                 3        2        3  2      |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3  3  3  3  3  3  3  2  3  3  3  3  3  1  2  3  4  2  2  3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +     +  +                       +              +  +  +|             
      Inguinal, Hyperplasia                |                                                    3                     |             
      Mediastinal, Hyperplasia             |                                                    3                    3|             
      Renal, Hyperplasia                   |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                   4      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                    +                    +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                2           4     3                 4        2     4      |             
      Hemorrhage                           |                                                                      3   |             
      Hyperplasia, Lymphoid                | 2           3        2                                      2  3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |          2                                                               |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
      Inflammation, Suppurative            |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Artery, Meninges, Inflammation,      |                                                                          |             
          Chronic                          |                                                                         2|             
      Meninges, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              1                           |             
      Pleura, Mediastinum, Inflammation,   |                                                                          |             
           Chronic                         |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Glands, Dilatation, Focal    | 1           2     2  1  1                    2           1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Peritracheal Tissue,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Inflammation, Chronic            |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                        +  +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Nephropathy                          | 1  2  1  1  1  2  1  2     2  1  2  1  1  1  1  1     1  1  1     2      |             
      Artery, Inflammation, Chronic        |                                                                         3|             
      Renal Tubule, Dilatation, Focal      |             1                                                            |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|             
                                           | 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.25%                                  | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation, Chronic                 |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      2                                                   |             
      Clear Cell Focus                     |                3                                                         |             
      Eosinophilic Focus                   | 1           1        2                                                   |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                               4                                          |             
      Infarct                              |                                                       4                  |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Focal                  |    1                    1                                                |             
      Mineralization, Focal                |                                                                         2|             
      Mixed Cell Focus                     |                   2                                                      |             
      Mixed Cell Focus, Multiple           |                      4                                                   |             
      Bile Duct, Cyst                      |                   3                                                      |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +     +                       +   |             
      Inflammation, Chronic                |                                              2                           |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                           +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Inflammation, Chronic                |                               2                                          |             
      Epithelium, Hyperplasia              |                               2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Degeneration, Cystic, Focal  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                  +      |             
      Incisor, Dysplasia                   |                1                                                  1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|             
                                           | 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.25%                                  | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                               3                                          |             
      Thrombosis                           |                               3                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  I  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |             2                                                            |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation                         |                                                                          |             
      C-Cell, Hyperplasia                  |                                           1                              |             
      Follicular Cell, Hyperplasia         |    2  2  1  2  2  2     1           4  2     1  1     2  3              1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Degeneration, Cystic                 |    3                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |             2           2                          4  3                  |             
      Inflammation, Suppurative            |                               4                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    3                                   3                       3  3      |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3  4  3  2  3     2  3  3  3  2  3  3  3  3  3  2  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +           +     +                             +   |             
      Inguinal, Hyperplasia                |                      2                                                   |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|             
                                           | 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.25%                                  | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |    1                                                                     |             
      Hyperplasia, Lymphoid                |       3                                         2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                               4     3     4  3           3  3     3      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 2              2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Ulcer                                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                     3                                    |             
      Artery, Meninges, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
      Meninges, Cyst                       |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                2                                                         |             
      Infiltration Cellular, Mixed Cell    |                               2                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Pleura, Mediastinum, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Glands, Dilatation, Focal    | 1  1  1                    2  1        1     1           1  2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Artery, Peritracheal Tissue,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|             
                                           | 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.25%                                  | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Cornea, Inflammation, Chronic        | 3                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +              +                                +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Osseous           |                                                       2                  |             
      Nephropathy                          | 1  1     1  1  2  2              1  1     2  2     1  2        1        1|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Renal Tubule, Dilatation, Focal      |                                                                          |             
      Renal Tubule, Pigmentation           |                                           3                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    0.25%                                  | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |  47        |
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  48        |
      Perforation, Chronic                 |                                                                          |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  47        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Basophilic Focus                     |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      2  2.5|
      Eosinophilic Focus                   |                                                                          |      9  1.6|
      Eosinophilic Focus, Multiple         |                                                                          |      1  3.0|
      Fatty Change, Focal                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  4.0|
      Inflammation, Focal                  |                                                                          |      2  1.0|
      Mineralization, Focal                |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Mixed Cell Focus, Multiple           |                                                                          |      1  4.0|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Inflammation, Chronic                |                                                                          |      3  2.7|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  49        |
      Atrophy, Focal                       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    0.25%                                  | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  49        |
      Glands, Degeneration, Cystic, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Incisor, Dysplasia                   |                                                                          |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  51        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M                                                                        |  46        |
      Angiectasis                          |                                                                          |      2  1.0|
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  50        |
      Inflammation                         |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         | 2                                                                        |     24  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  50        |
      Degeneration, Cystic                 |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  47        |
      Cyst                                 | 4                                                                        |     10  2.8|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    0.25%                                  | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  50        |
      Hydrometra                           |                                                                          |     12  2.7|
      Endometrium, Hyperplasia, Cystic     | 3                                                                        |     50  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  12        |
      Inguinal, Hyperplasia                |                                                                          |      2  2.5|
      Mediastinal, Hyperplasia             |                                                                          |      2  3.0|
      Renal, Hyperplasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |     13  3.2|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      7  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  47        |
      Cyst                                 | 2                                                                        |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Atrophy, Focal                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    0.25%                                  | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Artery, Meninges, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
      Meninges, Cyst                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Pleura, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  49        |
      Mucosa, Glands, Dilatation, Focal    |                                                                          |     16  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  50        |
      Artery, Peritracheal Tissue,         |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  50        |
      Metaplasia, Focal, Osseous           |                                                                          |      1  2.0|
      Nephropathy                          | 1                                                                        |     35  1.3|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Renal Tubule, Dilatation, Focal      |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|             
                                           | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Clear Cell Focus                     |                                                             3            |             
      Eosinophilic Focus                   |    1     4           1              2           1  2  2                  |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Focal, Lymphoid         |                                  2                                       |             
      Infiltration Cellular, Mixed Cell    |                                              2                 3         |             
      Inflammation, Focal                  |    1                                                        1            |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |                                                    2                     |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                      +     +           +         |             
      Inflammation, Chronic                |                                              3     2           3         |             
      Fat, Necrosis                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    2                     |             
      Pigmentation, Focal                  |                                                                          |             
      Ulcer                                |                                                    2                     |             
      Epithelium, Hyperplasia              |                                                    2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                3         |             
      Ulcer                                |                                                                2         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Dysplasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Mineralization, Focal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|             
                                           | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 1                                                                        |             
      Subcapsular, Hyperplasia, Focal      |                                                                      1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                             1            |             
      Follicular Cell, Hyperplasia         | 1  1  1  2     2     1  2     2           1           3                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |       3                                      2                           |             
      Cyst                                 |       2                                   4     3     2                 3|             
      Hyperplasia, Tubular                 |                                                                          |             
      Inflammation, Suppurative            | 3                                            4              3  4         |             
      Thrombosis                           |                                              2                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydrometra                           |                   2              2                    3                 3|             
      Inflammation, Suppurative            |             3                                               2  3         |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3  3  3  3  3  3  3  3  3  1  3  1  3  2  3     3  3  3  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +                                +                 +         |             
      Iliac, Hyperplasia                   |                                                                          |             
      Lumbar, Hyperplasia                  |                                                                4         |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Mediastinal, Inflammation, Focal,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|             
                                           | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Suppurative                     |                                                                          |             
      Renal, Hyperplasia                   |                                              4                 4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Hyperplasia                          |                                                                3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                                  |             
      Fibrosis, Focal                      |       2                                                                  |             
      Hematopoietic Cell Proliferation     | 2     2  2                 2                 3     3        2  4         |             
      Hyperplasia, Lymphoid                |                3     3                                2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia, Focal                      |                                                                          |             
      Epidermis, Hyperplasia, Focal        |                   2                                                      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic, Focal                  |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |          1                                                               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                    +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                              2                 3         |             
      Inflammation, Chronic, Focal         |                                           2                              |             
      Alveolar Epithelium, Hyperplasia     |                                           2                 1            |             
      Interstitium, Inflammation,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
      Pleura, Mediastinum, Inflammation,   |                                                                          |             
           Chronic                         |                                              3                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|             
                                           | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Glands, Dilatation, Focal    | 2     1  2                 2  2     2     2        1  1     2     1  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        2                                 |             
      Inflammation, Chronic                |                                                                3         |             
      Nephropathy                          | 1  1  1  1  1  1  1     1  1        1              1  1     1            |             
      Renal Tubule, Casts                  |                                                          3               |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemoglobin                       |                                                          3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |          2                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                  2                                       |             
      Eosinophilic Focus                   |       4                       2                    3                     |             
      Eosinophilic Focus, Multiple         |                                                                         3|             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Mixed Cell Focus                     |                               3                                          |             
      Necrosis, Focal                      |                                                                          |             
      Centrilobular, Necrosis              |                                              3                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +           +                                                     +|             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1                                                  3                  |             
      Pigmentation, Focal                  |                                                                          |             
      Ulcer                                |                                                       3                  |             
      Epithelium, Hyperplasia              |    2                                                  3     1            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Incisor, Dysplasia                   |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Mineralization, Focal    |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Subcapsular, Hyperplasia, Focal      |                   3                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2  1              1                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     M  +  +  +  +  M|             
      Angiectasis                          |       2                                                                  |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |          2                                                               |             
      Pars Distalis, Hyperplasia, Focal    |                         2                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Follicular Cell, Hyperplasia         | 1     1        2  1  1  3  1     2  1           2     3           1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2     2              3                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Cyst                                 |                      2           3                 2     2  2     4      |             
      Hyperplasia, Tubular                 |                                                 2                        |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                                                     |             
      Hydrometra                           | 3     3                    3  3     3     3              2        4      |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3  3  3  3  2  3  4  3  3  3  3  1  3  4  3  2  3  3  3  4  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +                                                         |             
      Iliac, Hyperplasia                   |                                                                          |             
      Lumbar, Hyperplasia                  |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                3                                                         |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Mediastinal, Inflammation, Focal,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Suppurative                     |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hemorrhage                           |                                                          2               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                            2        3        3                           |             
      Hyperplasia, Lymphoid                |             2                                      3              2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia, Focal                      |                                              2                           |             
      Epidermis, Hyperplasia, Focal        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic, Focal                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              4                           |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
      Pleura, Mediastinum, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Glands, Dilatation, Focal    | 2  1     2     2  1  1  1           1  2           2           1        2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          |       1  1  1     2  1  1                       1        1     1  1  1  1|             
      Renal Tubule, Casts                  |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemoglobin                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 0| 2| 3|                                                              |            |
                                           | 5| 1| 2| 6|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4|                                                              |      A     |
    0.5%                                   | 7| 7| 7| 8|                                                              |      L     |
                                           | 7| 8| 9| 0|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  53        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  54        |
      Angiectasis                          |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      2  2.5|
      Eosinophilic Focus                   | 3                                                                        |     11  2.3|
      Eosinophilic Focus, Multiple         |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    2                                                                     |      2  2.0|
      Hemorrhage, Focal                    |       2                                                                  |      1  2.0|
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |    2                                                                     |      3  2.3|
      Inflammation, Focal                  |                                                                          |      2  1.0|
      Mixed Cell Focus                     |                                                                          |      1  3.0|
      Necrosis, Focal                      |       4                                                                  |      2  3.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   8        |
      Inflammation, Chronic                |    3                                                                     |      4  2.8|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  54        |
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Pigmentation, Focal                  |       2                                                                  |      1  2.0|
      Ulcer                                |                                                                          |      2  2.5|
      Epithelium, Hyperplasia              |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  54        |
      Erosion                              |       1                                                                  |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Incisor, Dysplasia                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 0| 2| 3|                                                              |            |
                                           | 5| 1| 2| 6|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4|                                                              |      A     |
    0.5%                                   | 7| 7| 7| 8|                                                              |      L     |
                                           | 7| 8| 9| 0|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  54        |
      Myocardium, Mineralization, Focal    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +                                                               |  54        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Subcapsular, Hyperplasia, Focal      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +                                                               |  54        |
      Hyperplasia                          |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  54        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +                                                               |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M                                                               |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  54        |
      Inflammation, Chronic, Focal         |    1                                                                     |      2  1.0|
      Follicular Cell, Hyperplasia         |       1  1                                                               |     24  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +                                                               |  54        |
      Degeneration, Cystic                 |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +                                                               |  50        |
      Angiectasis                          |                                                                          |      3  2.3|
      Cyst                                 |                                                                          |     11  2.6|
      Hyperplasia, Tubular                 |                                                                          |      1  2.0|
      Inflammation, Suppurative            |    4                                                                     |      5  3.6|
      Thrombosis                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +                                                               |  54        |
      Cyst                                 |                                                                          |      1  2.0|
      Hydrometra                           |       3  3                                                               |     14  2.9|
      Inflammation, Suppurative            |                                                                          |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 0| 2| 3|                                                              |            |
                                           | 5| 1| 2| 6|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4|                                                              |      A     |
    0.5%                                   | 7| 7| 7| 8|                                                              |      L     |
                                           | 7| 8| 9| 0|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Hyperplasia, Cystic     | 3  3     3                                                               |     51  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +                                                                  |   9        |
      Iliac, Hyperplasia                   |    3                                                                     |      1  3.0|
      Lumbar, Hyperplasia                  |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia             |    3                                                                     |      1  3.0|
      Mediastinal, Inflammation, Focal,    |                                                                          |            |
           Suppurative                     |    3                                                                     |      1  3.0|
      Renal, Hyperplasia                   |    4                                                                     |      3  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +                                                               |  52        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  54        |
      Angiectasis                          |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |    4  4                                                                  |     13  2.8|
      Hyperplasia, Lymphoid                | 2                                                                        |      7  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +                                                               |  48        |
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                                                               |  54        |
      Alopecia, Focal                      |                                                                          |      1  2.0|
      Epidermis, Hyperplasia, Focal        |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic, Focal                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  54        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 0| 2| 3|                                                              |            |
                                           | 5| 1| 2| 6|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4|                                                              |      A     |
    0.5%                                   | 7| 7| 7| 8|                                                              |      L     |
                                           | 7| 8| 9| 0|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  54        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.5|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Interstitium, Inflammation,          |                                                                          |            |
          Suppurative                      |    2                                                                     |      1  2.0|
      Mediastinum, Inflammation, Chronic   |    2                                                                     |      1  2.0|
      Pleura, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  53        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mucosa, Glands, Dilatation, Focal    | 1     1                                                                  |     26  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  53        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Nephropathy                          | 1     2  1                                                               |     28  1.1|
      Renal Tubule, Casts                  |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemoglobin                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05217-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 19:29:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2|             
                                           | 7| 8| 8| 5| 7| 7| 8| 8| 7| 8| 8| 9| 9| 9| 2| 7| 9| 9| 9| 9| 0| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus