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TDMS Study 05217-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                               T-BUTYLHYDROQUINONE                                  DATE: 04/04/96       
EXPERIMENT: 05217 TEST: 03                                                                                     TIME: 07:15:00       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85219                              ROUTE: DOSED FEED                                              NTP C#: C62157       
PATHOLOGIST: J. E. HEATH                                                                                       CAS: 1948-33-0       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                               T-BUTYLHYDROQUINONE                                  DATE: 04/04/96       
EXPERIMENT: 05217 TEST: 03                                                                                     TIME: 07:15:00       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85219                              ROUTE: DOSED FEED                                              NTP C#: C62157       
PATHOLOGIST: J. E. HEATH                                                                                       CAS: 1948-33-0       




                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                               T-BUTYLHYDROQUINONE                                  DATE: 04/04/96       
EXPERIMENT: 05217 TEST: 03                                                                                     TIME: 07:15:00       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85219                              ROUTE: DOSED FEED                                              NTP C#: C62157       
PATHOLOGIST: J. E. HEATH                                                                                       CAS: 1948-33-0       




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF T-BUTYLHYDROQUINONE

              ====================================================================================================

                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Clitoral/Preputial Gland      Adenoma
                                            Carcinoma
                                            Carcinoma or Adenoma
              Liver                         Hepatocellular Carcinoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Testes                        Adenoma
              Thyroid Gland: Follicular Cell
                                            Carcinoma
                                            Carcinoma or Adenoma
              Tongue                        Squamous Cell Papilloma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Mesothelioma: Benign, Malignant, NOS
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================

                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
                                            Squamous Cell Carcinoma
              Skin                          Squamous Cell Papilloma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated

              ====================================================================================================
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE   1
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    0/68 (0%)    1/70 (1%)  |  4/140 (3%)   1/70 (1%)    0/68 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |   7.2%         0.0%         0.0%         4.8%      |   9.3%         3.6%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  1/32 (3%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   786          ---          ---          786       |   795          795          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.609N     P=0.491N     P=0.711N     P=0.705N   |  P=0.058N     P=0.527N     P=0.178N     P=0.161N   |
|INCIDENTAL TUMOR       |  P=0.636N     P=0.438N     P=0.613N     P=0.722    |  P=0.062N     P=0.412N     P=0.175N     P=0.181N   |
|LOGISTIC REGRESSION    |  P=0.636N     P=0.465N     P=0.566N     P=0.728    |  P=0.058N     P=0.476N     P=0.176N     P=0.158N   |
|COCHRAN-ARMITAGE       |  P=0.623N                                          |  P=0.067N                                          |
|FISHER EXACT           |               P=0.443N     P=0.452N     P=0.742N   |               P=0.459N     P=0.202N     P=0.195N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 26/140 (19%) 20/69 (29%)  15/68 (22%)  12/70 (17%) |  4/140 (3%)   2/70 (3%)    1/68 (1%)    3/70 (4%)  |
|ADJUSTED (b)           |  51.7%        85.5%       100.0%        49.8%      |  10.1%        18.2%         3.1%        12.3%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/9 (0%)     0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/20 (20%)   5/7 (71%)    1/1 (100%)   5/14 (36%) |  2/32 (6%)    2/11 (18%)   0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   617          655          473          487       |   817          898 (T)      789          750       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.445N     P=0.012 *    P=0.004 **   P=0.412N   |  P=0.494      P=0.539      P=0.430N     P=0.516    |
|INCIDENTAL TUMOR       |  P=0.528N     P=0.044 *    P=0.137      P=0.525N   |  P=0.442      P=0.595      P=0.418N     P=0.464    |
|LOGISTIC REGRESSION    |  P=0.497N     P=0.021 *    P=0.071      P=0.519N   |  P=0.487      P=0.602      P=0.422N     P=0.510    |
|COCHRAN-ARMITAGE       |  P=0.395N                                          |  P=0.412                                           |
|FISHER EXACT           |               P=0.064      P=0.338      P=0.480N   |               P=0.682N     P=0.472N     P=0.429    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE   2
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   3/69 (4%)    1/68 (1%)    3/70 (4%)  |  1/140 (1%)   0/70 (0%)    0/68 (0%)    1/70 (1%)  |
|ADJUSTED (b)           |   6.3%        23.8%         5.0%        21.4%      |   2.6%         0.0%         0.0%         5.3%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/9 (0%)     0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    1/7 (14%)    0/1 (0%)     3/14 (21%) |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   710          702          738          857 (T)   |   865          ---          ---          894       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.271      P=0.128      P=0.534      P=0.303    |  P=0.515      P=0.685N     P=0.609N     P=0.647    |
|INCIDENTAL TUMOR       |  P=0.248      P=0.173      P=0.593      P=0.291    |  P=0.463      P=0.607N     P=0.623N     P=0.603    |
|LOGISTIC REGRESSION    |  P=0.201      P=0.154      P=0.656      P=0.208    |  P=0.506      P=0.667N     P=0.630N     P=0.641    |
|COCHRAN-ARMITAGE       |  P=0.221                                           |  P=0.461                                           |
|FISHER EXACT           |               P=0.203      P=0.697      P=0.207    |               P=0.667N     P=0.673N     P=0.557    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/140 (19%) 21/69 (30%)  16/68 (24%)  13/70 (19%) |  5/140 (4%)   2/70 (3%)    1/68 (1%)    4/70 (6%)  |
|ADJUSTED (b)           |  54.7%        85.9%       100.0%        55.4%      |  12.4%        18.2%         3.1%        16.9%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/9 (0%)     0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  5/20 (25%)   5/7 (71%)    1/1 (100%)   6/14 (43%) |  2/32 (6%)    2/11 (18%)   0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   617          655          473          487       |   817          898 (T)      789          750       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.482N     P=0.009 **   P=0.002 **   P=0.437N   |  P=0.426      P=0.631      P=0.316N     P=0.447    |
|INCIDENTAL TUMOR       |  P=0.494      P=0.033 *    P=0.089      P=0.551N   |  P=0.357      P=0.623N     P=0.311N     P=0.376    |
|LOGISTIC REGRESSION    |  P=0.516      P=0.015 *    P=0.048 *    P=0.575N   |  P=0.414      P=0.642N     P=0.314N     P=0.434    |
|COCHRAN-ARMITAGE       |  P=0.445N                                          |  P=0.330                                           |
|FISHER EXACT           |               P=0.053      P=0.296      P=0.530N   |               P=0.571N     P=0.361N     P=0.348    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE   3
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   1/70 (1%)    0/68 (0%)    0/70 (0%)  |  1/140 (1%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |   2.3%         2.0%         0.0%         0.0%      |   3.1%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  1/32 (3%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   556          564          ---          ---       |   898 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.215N     P=0.707      P=0.461N     P=0.413N   |  P=0.384N     P=0.712N     P=0.638N     P=0.626N   |
|INCIDENTAL TUMOR       |  P=0.155N     P=0.725      P=0.326N     P=0.393N   |  P=0.384N     P=0.712N     P=0.638N     P=0.626N   |
|LOGISTIC REGRESSION    |  P=0.198N     P=0.729N     P=0.411N     P=0.401N   |  P=0.384N     P=0.712N     P=0.638N     P=0.627N   |
|COCHRAN-ARMITAGE       |  P=0.199N                                          |  P=0.396N                                          |
|FISHER EXACT           |               P=0.742N     P=0.452N     P=0.443N   |               P=0.667N     P=0.673N     P=0.667N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/140 (4%)   3/70 (4%)    6/68 (9%)    3/70 (4%)  | 10/137 (7%)   6/69 (9%)    5/68 (7%)    7/70 (10%) |
|ADJUSTED (b)           |  13.4%        20.0%       100.0%        18.4%      |  22.6%        23.5%        22.2%        27.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/20 (10%)   0/7 (0%)     1/1 (100%)   2/14 (14%) |  5/32 (16%)   0/10 (0%)    3/16 (19%)   2/17 (12%) |
|FIRST INCIDENCE (DAYS) |   528          766          526          786       |   579          649          661          628       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.385      P=0.411      P=0.006 **   P=0.622    |  P=0.432      P=0.296      P=0.609N     P=0.424    |
|INCIDENTAL TUMOR       |  P=0.400      P=0.534      P=0.061      P=0.625    |  P=0.395      P=0.470      P=0.587N     P=0.427    |
|LOGISTIC REGRESSION    |  P=0.324      P=0.496      P=0.068      P=0.534    |  P=0.406      P=0.413      P=0.578N     P=0.426    |
|COCHRAN-ARMITAGE       |  P=0.354                                           |  P=0.322                                           |
|FISHER EXACT           |               P=0.534      P=0.107      P=0.534    |               P=0.459      P=0.596      P=0.337    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE   4
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   2/70 (3%)    2/68 (3%)    5/70 (7%)  |  8/137 (6%)   4/69 (6%)    5/68 (7%)    8/70 (11%) |
|ADJUSTED (b)           |   1.8%         7.9%         6.0%        18.4%      |  16.5%        16.0%        18.8%        29.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     1/14 (7%)  |  4/32 (13%)   1/10 (10%)   0/16 (0%)    2/17 (12%) |
|FIRST INCIDENCE (DAYS) |   381          467          604          520       |   648          666          767          750       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.028 *    P=0.383      P=0.346      P=0.044 *  |  P=0.149      P=0.490      P=0.487      P=0.173    |
|INCIDENTAL TUMOR       |  P=0.039 *    P=0.470      P=0.624      P=0.067    |  P=0.103      P=0.590      P=0.519      P=0.141    |
|LOGISTIC REGRESSION    |  P=0.024 *    P=0.439      P=0.431      P=0.038 *  |  P=0.121      P=0.614      P=0.486      P=0.163    |
|COCHRAN-ARMITAGE       |  P=0.025 *                                         |  P=0.089                                           |
|FISHER EXACT           |               P=0.407      P=0.396      P=0.043 *  |               P=0.629N     P=0.443      P=0.126    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/140 (5%)   5/70 (7%)    7/68 (10%)   8/70 (11%) | 18/137 (13%) 10/69 (14%)  10/68 (15%)  14/70 (20%) |
|ADJUSTED (b)           |  15.0%        26.3%       100.0%        34.2%      |  37.1%        35.8%        36.8%        47.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/20 (10%)   0/7 (0%)     1/1 (100%)   3/14 (21%) |  9/32 (28%)   1/10 (10%)   3/16 (19%)   4/17 (24%) |
|FIRST INCIDENCE (DAYS) |   381          467          526          520       |   579          649          661          628       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.069      P=0.249      P=0.013 *    P=0.108    |  P=0.232      P=0.259      P=0.493      P=0.214    |
|INCIDENTAL TUMOR       |  P=0.078      P=0.385      P=0.124      P=0.134    |  P=0.166      P=0.449      P=0.535      P=0.189    |
|LOGISTIC REGRESSION    |  P=0.044 *    P=0.354      P=0.101      P=0.072    |  P=0.184      P=0.433      P=0.517      P=0.202    |
|COCHRAN-ARMITAGE       |  P=0.050                                           |  P=0.121                                           |
|FISHER EXACT           |               P=0.366      P=0.129      P=0.080    |               P=0.472      P=0.457      P=0.139    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE   5
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/140 (0%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |  0/140 (0%)   0/70 (0%)    2/68 (3%)    0/70 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.2%         0.0%      |   0.0%         0.0%         9.1%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          578          ---       |   ---          ---          788          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.597        (e)        P=0.328        (e)      |  P=0.492        (e)        P=0.107        (e)      |
|INCIDENTAL TUMOR       |  P=0.668        (e)        P=0.500        (e)      |  P=0.475        (e)        P=0.112        (e)      |
|LOGISTIC REGRESSION    |  P=0.606        (e)        P=0.362        (e)      |  P=0.488        (e)        P=0.108        (e)      |
|COCHRAN-ARMITAGE       |  P=0.604                                           |  P=0.461                                           |
|FISHER EXACT           |                 (e)        P=0.327        (e)      |                 (e)        P=0.106        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/140 (5%)   2/69 (3%)    1/68 (1%)    3/70 (4%)  |  3/140 (2%)   1/69 (1%)    3/67 (4%)    2/69 (3%)  |
|ADJUSTED (b)           |  19.1%         7.6%         5.3%        15.9%      |   7.0%         1.8%        14.4%         9.8%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/20 (10%)   0/7 (0%)     0/1 (0%)     1/14 (7%)  |  1/32 (3%)    0/11 (0%)    1/16 (6%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   667          697          744          708       |   661          537          816          869       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.424N     P=0.502N     P=0.534N     P=0.489N   |  P=0.457      P=0.621N     P=0.359      P=0.619    |
|INCIDENTAL TUMOR       |  P=0.481N     P=0.392N     P=0.352N     P=0.584N   |  P=0.333      P=0.579N     P=0.353      P=0.577    |
|LOGISTIC REGRESSION    |  P=0.455N     P=0.434N     P=0.320N     P=0.567N   |  P=0.410      P=0.582N     P=0.339      P=0.604    |
|COCHRAN-ARMITAGE       |  P=0.413N                                          |  P=0.367                                           |
|FISHER EXACT           |               P=0.381N     P=0.200N     P=0.559N   |               P=0.598N     P=0.299      P=0.534    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE   6
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/140 (6%)   2/69 (3%)    1/68 (1%)    3/70 (4%)  |  3/140 (2%)   1/69 (1%)    4/67 (6%)    2/69 (3%)  |
|ADJUSTED (b)           |  23.6%         7.6%         5.3%        15.9%      |   7.0%         1.8%        20.1%         9.8%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/20 (15%)   0/7 (0%)     0/1 (0%)     1/14 (7%)  |  1/32 (3%)    0/11 (0%)    2/16 (13%)   1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   667          697          744          708       |   661          537          816          869       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.330N     P=0.428N     P=0.515N     P=0.386N   |  P=0.415      P=0.621N     P=0.192      P=0.619    |
|INCIDENTAL TUMOR       |  P=0.374N     P=0.328N     P=0.339N     P=0.471N   |  P=0.300      P=0.579N     P=0.186      P=0.577    |
|LOGISTIC REGRESSION    |  P=0.364N     P=0.363N     P=0.277N     P=0.476N   |  P=0.374      P=0.582N     P=0.178      P=0.604    |
|COCHRAN-ARMITAGE       |  P=0.320N                                          |  P=0.325                                           |
|FISHER EXACT           |               P=0.301N     P=0.146N     P=0.470N   |               P=0.598N     P=0.155      P=0.534    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    1/68 (1%)    1/70 (1%)  |  1/140 (1%)   0/70 (0%)    0/67 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |   2.6%         0.0%         9.1%         5.3%      |   3.1%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  1/32 (3%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   694          ---          786          806       |   898 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.537      P=0.432N     P=0.613      P=0.713    |  P=0.384N     P=0.712N     P=0.638N     P=0.626N   |
|INCIDENTAL TUMOR       |  P=0.505      P=0.392N     P=0.702      P=0.671    |  P=0.384N     P=0.712N     P=0.638N     P=0.626N   |
|LOGISTIC REGRESSION    |  P=0.561      P=0.410N     P=0.691      P=0.727    |  P=0.383N     P=0.712N     P=0.638N     P=0.627N   |
|COCHRAN-ARMITAGE       |  P=0.578                                           |  P=0.396N                                          |
|FISHER EXACT           |               P=0.443N     P=0.697      P=0.742N   |               P=0.667N     P=0.676N     P=0.667N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE   7
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/140 (4%)   4/70 (6%)    0/68 (0%)    3/70 (4%)  |  0/140 (0%)   1/70 (1%)    2/68 (3%)    2/70 (3%)  |
|ADJUSTED (b)           |  11.3%        23.7%         0.0%        12.7%      |   0.0%         2.4%        10.5%         7.5%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    1/7 (14%)    0/1 (0%)     1/14 (7%)  |  0/32 (0%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   642          697          ---          708       |   ---          697          883          831       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.522N     P=0.245      P=0.287N     P=0.572    |  P=0.101      P=0.348      P=0.125      P=0.151    |
|INCIDENTAL TUMOR       |  P=0.549N     P=0.328      P=0.157N     P=0.539    |  P=0.068      P=0.393      P=0.112      P=0.107    |
|LOGISTIC REGRESSION    |  P=0.550N     P=0.303      P=0.175N     P=0.536    |  P=0.083      P=0.361      P=0.117      P=0.125    |
|COCHRAN-ARMITAGE       |  P=0.519N                                          |  P=0.066                                           |
|FISHER EXACT           |               P=0.348      P=0.135N     P=0.534    |               P=0.333      P=0.106      P=0.110    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/140 (0%)   0/70 (0%)    0/68 (0%)    2/70 (3%)  |  0/140 (0%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         9.5%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          767       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.029 *      (e)          (e)        P=0.101    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.013 *      (e)          (e)        P=0.069    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.025 *      (e)          (e)        P=0.099    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.023 *                                         |    (e)                                             |
|FISHER EXACT           |                 (e)          (e)        P=0.110    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE   8
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/140 (4%)   4/70 (6%)    0/68 (0%)    5/70 (7%)  |  0/140 (0%)   1/70 (1%)    2/68 (3%)    2/70 (3%)  |
|ADJUSTED (b)           |  11.3%        23.7%         0.0%        21.0%      |   0.0%         2.4%        10.5%         7.5%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    1/7 (14%)    0/1 (0%)     1/14 (7%)  |  0/32 (0%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   642          697          ---          708       |   ---          697          883          831       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.272      P=0.245      P=0.287N     P=0.228    |  P=0.101      P=0.348      P=0.125      P=0.151    |
|INCIDENTAL TUMOR       |  P=0.228      P=0.328      P=0.157N     P=0.179    |  P=0.068      P=0.393      P=0.112      P=0.107    |
|LOGISTIC REGRESSION    |  P=0.239      P=0.303      P=0.175N     P=0.196    |  P=0.083      P=0.361      P=0.117      P=0.125    |
|COCHRAN-ARMITAGE       |  P=0.265                                           |  P=0.066                                           |
|FISHER EXACT           |               P=0.348      P=0.135N     P=0.208    |               P=0.333      P=0.106      P=0.110    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/140 (4%)   4/70 (6%)    0/68 (0%)    5/70 (7%)  |  0/140 (0%)   1/70 (1%)    2/68 (3%)    2/70 (3%)  |
|ADJUSTED (b)           |  11.3%        23.7%         0.0%        21.0%      |   0.0%         2.4%        10.5%         7.5%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    1/7 (14%)    0/1 (0%)     1/14 (7%)  |  0/32 (0%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   642          697          ---          708       |   ---          697          883          831       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.272      P=0.245      P=0.287N     P=0.228    |  P=0.101      P=0.348      P=0.125      P=0.151    |
|INCIDENTAL TUMOR       |  P=0.228      P=0.328      P=0.157N     P=0.179    |  P=0.068      P=0.393      P=0.112      P=0.107    |
|LOGISTIC REGRESSION    |  P=0.239      P=0.303      P=0.175N     P=0.196    |  P=0.083      P=0.361      P=0.117      P=0.125    |
|COCHRAN-ARMITAGE       |  P=0.265                                           |  P=0.066                                           |
|FISHER EXACT           |               P=0.348      P=0.135N     P=0.208    |               P=0.333      P=0.106      P=0.110    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE   9
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/140 (4%)   2/70 (3%)    1/68 (1%)    1/70 (1%)  |  2/140 (1%)   2/70 (3%)    1/68 (1%)    1/70 (1%)  |
|ADJUSTED (b)           |  10.4%         8.2%         2.4%         4.3%      |   4.8%        18.2%         4.5%         5.9%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  1/32 (3%)    2/11 (18%)   0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   618          708          604          773       |   802          898 (T)      883          898 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.243N     P=0.649N     P=0.566N     P=0.327N   |  P=0.509N     P=0.312      P=0.711N     P=0.701N   |
|INCIDENTAL TUMOR       |  P=0.221N     P=0.569N     P=0.332N     P=0.350N   |  P=0.538N     P=0.340      P=0.715N     P=0.717N   |
|LOGISTIC REGRESSION    |  P=0.226N     P=0.590N     P=0.385N     P=0.339N   |  P=0.489N     P=0.365      P=0.720N     P=0.689N   |
|COCHRAN-ARMITAGE       |  P=0.211N                                          |  P=0.568N                                          |
|FISHER EXACT           |               P=0.571N     P=0.361N     P=0.348N   |               P=0.407      P=0.697      P=0.742N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/140 (2%)   0/70 (0%)    0/68 (0%)    1/70 (1%)  |  0/140 (0%)   1/70 (1%)    0/68 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |  12.6%         0.0%         0.0%         7.1%      |   0.0%         4.5%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/20 (10%)   0/7 (0%)     0/1 (0%)     1/14 (7%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   814          ---          ---          857 (T)   |   ---          831          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.397N     P=0.355N     P=0.709N     P=0.483N   |  P=0.609N     P=0.340        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.394N     P=0.320N     P=0.571N     P=0.493N   |  P=0.658N     P=0.393        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.428N     P=0.342N     P=0.499N     P=0.543N   |  P=0.639N     P=0.346        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.422N                                          |  P=0.656N                                          |
|FISHER EXACT           |               P=0.294N     P=0.303N     P=0.593N   |               P=0.333        (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  10
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/140 (6%)   2/70 (3%)    1/68 (1%)    2/70 (3%)  |  2/140 (1%)   3/70 (4%)    1/68 (1%)    1/70 (1%)  |
|ADJUSTED (b)           |  22.2%         8.2%         2.4%        11.2%      |   4.8%        21.9%         4.5%         5.9%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/20 (15%)   0/7 (0%)     0/1 (0%)     1/14 (7%)  |  1/32 (3%)    2/11 (18%)   0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   618          708          604          773       |   802          831          883          898 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.185N     P=0.410N     P=0.471N     P=0.237N   |  P=0.454N     P=0.128      P=0.711N     P=0.701N   |
|INCIDENTAL TUMOR       |  P=0.167N     P=0.325N     P=0.234N     P=0.256N   |  P=0.495N     P=0.161      P=0.715N     P=0.717N   |
|LOGISTIC REGRESSION    |  P=0.192N     P=0.341N     P=0.216N     P=0.297N   |  P=0.447N     P=0.161      P=0.720N     P=0.689N   |
|COCHRAN-ARMITAGE       |  P=0.166N                                          |  P=0.523N                                          |
|FISHER EXACT           |               P=0.293N     P=0.146N     P=0.293N   |               P=0.207      P=0.697      P=0.742N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |  6/140 (4%)   0/70 (0%)    1/68 (1%)    2/70 (3%)  |
|ADJUSTED (b)           |   4.4%         0.0%        25.0%         0.0%      |   9.2%         0.0%         2.9%         8.6%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  1/32 (3%)    0/11 (0%)    0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   668          ---          852          ---       |   613          ---          774          807       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.340N     P=0.451N     P=0.541      P=0.417N   |  P=0.315N     P=0.112N     P=0.246N     P=0.397N   |
|INCIDENTAL TUMOR       |  P=0.376N     P=0.392N     P=0.702      P=0.462N   |  P=0.300N     P=0.080N     P=0.254N     P=0.357N   |
|LOGISTIC REGRESSION    |  P=0.346N     P=0.423N     P=0.637      P=0.407N   |  P=0.344N     P=0.095N     P=0.254N     P=0.429N   |
|COCHRAN-ARMITAGE       |  P=0.323N                                          |  P=0.362N                                          |
|FISHER EXACT           |               P=0.443N     P=0.697      P=0.443N   |               P=0.085N     P=0.271N     P=0.466N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  11
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/140 (0%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |  9/140 (6%)   6/70 (9%)    2/68 (3%)    4/70 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  13.1%        35.4%        10.8%        10.5%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  1/32 (3%)    3/11 (27%)   0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   540          640          890          690       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.284N     P=0.279      P=0.217N     P=0.466N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.344N     P=0.401      P=0.235N     P=0.555N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.323N     P=0.369      P=0.224N     P=0.516N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.363N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.379      P=0.241N     P=0.552N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  | 14/140 (10%)  6/70 (9%)    3/68 (4%)    6/70 (9%)  |
|ADJUSTED (b)           |   4.4%         0.0%        25.0%         0.0%      |  20.3%        35.4%        13.4%        18.2%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  2/32 (6%)    3/11 (27%)   0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   668          ---          852          ---       |   540          640          774          690       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.340N     P=0.451N     P=0.541      P=0.417N   |  P=0.240N     P=0.596N     P=0.125N     P=0.379N   |
|INCIDENTAL TUMOR       |  P=0.376N     P=0.392N     P=0.702      P=0.462N   |  P=0.287N     P=0.441N     P=0.126N     P=0.441N   |
|LOGISTIC REGRESSION    |  P=0.346N     P=0.423N     P=0.637      P=0.407N   |  P=0.281N     P=0.485N     P=0.124N     P=0.471N   |
|COCHRAN-ARMITAGE       |  P=0.323N                                          |  P=0.325N                                          |
|FISHER EXACT           |               P=0.443N     P=0.697      P=0.443N   |               P=0.476N     P=0.132N     P=0.476N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  12
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 16/140 (11%)  4/70 (6%)    4/68 (6%)    7/70 (10%) | 66/140 (47%) 33/70 (47%)  34/68 (50%)  27/70 (39%) |
|ADJUSTED (b)           |  51.9%        40.7%        24.8%        40.2%      |  82.1%        96.6%        86.0%        74.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  8/20 (40%)   2/7 (29%)    0/1 (0%)     5/14 (36%) | 20/32 (63%)  10/11 (91%)  11/16 (69%)   9/17 (53%) |
|FIRST INCIDENCE (DAYS) |   381          786          619          708       |   418          537          600          596       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.316N     P=0.317N     P=0.348      P=0.276N   |  P=0.061N     P=0.196      P=0.541      P=0.082N   |
|INCIDENTAL TUMOR       |  P=0.345N     P=0.199N     P=0.514N     P=0.342N   |  P=0.062N     P=0.557N     P=0.522      P=0.054N   |
|LOGISTIC REGRESSION    |  P=0.450N     P=0.271N     P=0.399N     P=0.474N   |  P=0.050N*    P=0.498      P=0.485      P=0.062N   |
|COCHRAN-ARMITAGE       |  P=0.387N                                          |  P=0.167N                                          |
|FISHER EXACT           |               P=0.139N     P=0.153N     P=0.477N   |               P=0.559N     P=0.405      P=0.151N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/140 (13%)  4/70 (6%)    5/68 (7%)    7/70 (10%) | 70/140 (50%) 33/70 (47%)  34/68 (50%)  27/70 (39%) |
|ADJUSTED (b)           |  54.0%        40.7%        43.6%        40.2%      |  84.1%        96.6%        86.0%        74.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  8/20 (40%)   2/7 (29%)    0/1 (0%)     5/14 (36%) | 21/32 (66%)  10/11 (91%)  11/16 (69%)   9/17 (53%) |
|FIRST INCIDENCE (DAYS) |   381          786          619          708       |   418          537          600          596       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.243N     P=0.226N     P=0.267      P=0.194N   |  P=0.031N*    P=0.296      P=0.428N     P=0.045N*  |
|INCIDENTAL TUMOR       |  P=0.274N     P=0.124N     P=0.531N     P=0.254N   |  P=0.021N*    P=0.378N     P=0.444N     P=0.016N*  |
|LOGISTIC REGRESSION    |  P=0.354N     P=0.177N     P=0.455N     P=0.356N   |  P=0.018N*    P=0.449N     P=0.476N     P=0.025N*  |
|COCHRAN-ARMITAGE       |  P=0.295N                                          |  P=0.087N                                          |
|FISHER EXACT           |               P=0.084N     P=0.171N     P=0.360N   |               P=0.404N     P=0.559N     P=0.078N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  13
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/140 (13%)  4/70 (6%)    5/68 (7%)    7/70 (10%) | 74/140 (53%) 34/70 (49%)  34/68 (50%)  30/70 (43%) |
|ADJUSTED (b)           |  54.0%        40.7%        43.6%        40.2%      |  84.9%        96.6%        86.0%        76.3%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  8/20 (40%)   2/7 (29%)    0/1 (0%)     5/14 (36%) | 21/32 (66%)  10/11 (91%)  11/16 (69%)   9/17 (53%) |
|FIRST INCIDENCE (DAYS) |   381          786          619          708       |   418          537          600          596       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.243N     P=0.226N     P=0.267      P=0.194N   |  P=0.042N*    P=0.352      P=0.315N     P=0.067N   |
|INCIDENTAL TUMOR       |  P=0.274N     P=0.124N     P=0.531N     P=0.254N   |  P=0.030N*    P=0.280N     P=0.290N     P=0.030N*  |
|LOGISTIC REGRESSION    |  P=0.354N     P=0.177N     P=0.455N     P=0.356N   |  P=0.026N*    P=0.352N     P=0.308N     P=0.040N*  |
|COCHRAN-ARMITAGE       |  P=0.295N                                          |  P=0.109N                                          |
|FISHER EXACT           |               P=0.084N     P=0.171N     P=0.360N   |               P=0.330N     P=0.405N     P=0.111N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/140 (0%)   1/70 (1%)    0/68 (0%)    2/70 (3%)  |  1/140 (1%)   1/70 (1%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |   0.0%         4.8%         0.0%         9.3%      |   3.1%         6.7%         6.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     1/14 (7%)  |  1/32 (3%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          745          ---          647       |   898 (T)      873          898 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.089      P=0.295        (e)        P=0.125    |  P=0.430N     P=0.528      P=0.600      P=0.626N   |
|INCIDENTAL TUMOR       |  P=0.072      P=0.369        (e)        P=0.113    |  P=0.451N     P=0.576      P=0.600      P=0.626N   |
|LOGISTIC REGRESSION    |  P=0.069      P=0.344        (e)        P=0.100    |  P=0.410N     P=0.552      P=0.600      P=0.627N   |
|COCHRAN-ARMITAGE       |  P=0.070                                           |  P=0.471N                                          |
|FISHER EXACT           |               P=0.333        (e)        P=0.110    |               P=0.557      P=0.548      P=0.667N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  14
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/140 (2%)   1/70 (1%)    2/68 (3%)    0/70 (0%)  |  0/140 (0%)   0/70 (0%)    2/68 (3%)    0/70 (0%)  |
|ADJUSTED (b)           |   4.4%         1.7%         7.2%         0.0%      |   0.0%         0.0%         3.6%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   489          289          619          ---       |   ---          ---          425          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.284N     P=0.629N     P=0.419      P=0.285N   |  P=0.474        (e)        P=0.109        (e)      |
|INCIDENTAL TUMOR       |  P=0.258N     P=0.246N     P=0.654      P=0.271N   |  P=0.389        (e)        P=0.037 *      (e)      |
|LOGISTIC REGRESSION    |  P=0.255N     P=0.562N     P=0.534      P=0.270N   |  P=0.452        (e)        P=0.098        (e)      |
|COCHRAN-ARMITAGE       |  P=0.257N                                          |  P=0.461                                           |
|FISHER EXACT           |               P=0.593N     P=0.528      P=0.294N   |                 (e)        P=0.106        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/140 (2%)   2/70 (3%)    2/68 (3%)    2/70 (3%)  |  1/140 (1%)   1/70 (1%)    3/68 (4%)    0/70 (0%)  |
|ADJUSTED (b)           |   4.4%         6.3%         7.2%         9.3%      |   3.1%         6.7%         9.6%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     1/14 (7%)  |  1/32 (3%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   489          289          619          647       |   898 (T)      873          425          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.446      P=0.485      P=0.419      P=0.569    |  P=0.576N     P=0.528      P=0.109      P=0.626N   |
|INCIDENTAL TUMOR       |  P=0.419      P=0.538N     P=0.654      P=0.569    |  P=0.593      P=0.576      P=0.059      P=0.626N   |
|LOGISTIC REGRESSION    |  P=0.458      P=0.568      P=0.534      P=0.559    |  P=0.610N     P=0.552      P=0.101      P=0.627N   |
|COCHRAN-ARMITAGE       |  P=0.461                                           |  P=0.616                                           |
|FISHER EXACT           |               P=0.541      P=0.528      P=0.541    |               P=0.557      P=0.103      P=0.667N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  15
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/140 (1%)   1/70 (1%)    2/68 (3%)    0/70 (0%)  |  0/140 (0%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |   0.8%         1.7%         7.2%         0.0%      |   0.0%         0.0%         1.8%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   489          289          619          ---       |   ---          ---          425          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.563N     P=0.592      P=0.197      P=0.645N   |  P=0.612        (e)        P=0.364        (e)      |
|INCIDENTAL TUMOR       |  P=0.569N     P=0.594N     P=0.409      P=0.557N   |  P=0.395        (e)        P=0.186        (e)      |
|LOGISTIC REGRESSION    |  P=0.550N     P=0.614      P=0.262      P=0.636N   |  P=0.597        (e)        P=0.353        (e)      |
|COCHRAN-ARMITAGE       |  P=0.555N                                          |  P=0.604                                           |
|FISHER EXACT           |               P=0.557      P=0.250      P=0.667N   |                 (e)        P=0.327        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/140 (1%)   2/70 (3%)    0/67 (0%)    1/70 (1%)  |
|ADJUSTED (b)           |                                                    |   2.7%         6.1%         0.0%         5.9%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  0/32 (0%)    0/11 (0%)    0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   879          683          ---          898 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.619      P=0.227      P=0.604N     P=0.632    |
|INCIDENTAL TUMOR       |                                                    |  P=0.589      P=0.317      P=0.623N     P=0.608    |
|LOGISTIC REGRESSION    |                                                    |  P=0.602      P=0.259      P=0.626N     P=0.647    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.577                                           |
|FISHER EXACT           |                                                    |               P=0.258      P=0.676N     P=0.557    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  16
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/140 (2%)   0/69 (0%)    1/68 (1%)    0/70 (0%)  |  0/140 (0%)   0/70 (0%)    0/67 (0%)    0/69 (0%)  |
|ADJUSTED (b)           |  15.0%         0.0%        25.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/20 (15%)   0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   857 (T)      ---          852          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.181N     P=0.352N     P=0.349      P=0.187N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.193N     P=0.352N     P=0.465      P=0.187N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.183N     P=0.352N     P=0.484      P=0.187N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.193N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.298N     P=0.604N     P=0.294N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/131 (0%)   0/64 (0%)    0/65 (0%)    0/66 (0%)  |  3/126 (2%)   0/65 (0%)    0/63 (0%)    1/62 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   6.6%         0.0%         0.0%         6.3%      |
|INTERIM SACRIFICE 1 (c)|  0/19 (0%)    0/10 (0%)    0/10 (0%)    0/8 (0%)   |  0/19 (0%)    0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/19 (0%)    0/7 (0%)     0/1 (0%)     0/13 (0%)  |  1/27 (4%)    0/9 (0%)     0/16 (0%)    1/16 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   785          ---          ---          898 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.367N     P=0.314N     P=0.259N     P=0.510N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.387N     P=0.267N     P=0.251N     P=0.538N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.378N     P=0.284N     P=0.253N     P=0.523N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.425N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.285N     P=0.294N     P=0.599N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  17
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 38/139 (27%) 16/68 (24%)  17/66 (26%)   6/70 (9%)  | 57/139 (41%) 27/70 (39%)  34/67 (51%)  28/70 (40%) |
|ADJUSTED (b)           |  68.0%        80.0%       100.0%        30.2%      |  74.3%        75.2%        90.7%        69.8%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  9/20 (45%)   4/6 (67%)    1/1 (100%)   3/14 (21%) | 15/32 (47%)   5/11 (45%)  13/16 (81%)   7/17 (41%) |
|FIRST INCIDENCE (DAYS) |   528          562          562          668       |   523          480          600          501       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.008N**   P=0.431      P=0.034 *    P=0.002N** |  P=0.313N     P=0.353      P=0.270      P=0.297N   |
|INCIDENTAL TUMOR       |  P=0.003N**   P=0.426N     P=0.421      P=0.001N** |  P=0.504N     P=0.342N     P=0.161      P=0.372N   |
|LOGISTIC REGRESSION    |  P=0.003N**   P=0.484N     P=0.415      P=0.001N** |  P=0.443N     P=0.460N     P=0.152      P=0.360N   |
|COCHRAN-ARMITAGE       |  P=0.002N**                                        |  P=0.449                                           |
|FISHER EXACT           |               P=0.341N     P=0.476N     P<0.001N** |               P=0.426N     P=0.121      P=0.505N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/139 (1%)   1/68 (1%)    1/66 (2%)    1/70 (1%)  |  4/139 (3%)   1/70 (1%)    1/67 (1%)    3/70 (4%)  |
|ADJUSTED (b)           |   4.3%         5.6%         4.2%         2.1%      |   6.4%         9.1%         6.3%        10.1%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/6 (0%)     0/1 (0%)     0/14 (0%)  |  1/32 (3%)    1/11 (9%)    1/16 (6%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   841          766          725          627       |   540          898 (T)      898 (T)      666       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.449      P=0.537      P=0.465      P=0.617    |  P=0.417      P=0.515N     P=0.431N     P=0.476    |
|INCIDENTAL TUMOR       |  P=0.421      P=0.612      P=0.572      P=0.608    |  P=0.340      P=0.465N     P=0.484N     P=0.382    |
|LOGISTIC REGRESSION    |  P=0.435      P=0.538      P=0.503      P=0.596    |  P=0.403      P=0.440N     P=0.441N     P=0.467    |
|COCHRAN-ARMITAGE       |  P=0.447                                           |  P=0.376                                           |
|FISHER EXACT           |               P=0.550      P=0.541      P=0.559    |               P=0.456N     P=0.476N     P=0.433    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  18
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 39/139 (28%) 17/68 (25%)  18/66 (27%)   7/70 (10%) | 61/139 (44%) 28/70 (40%)  35/67 (52%)  31/70 (44%) |
|ADJUSTED (b)           |  69.4%        81.1%       100.0%        31.6%      |  76.7%        79.3%        93.8%        74.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  9/20 (45%)   4/6 (67%)    1/1 (100%)   3/14 (21%) | 16/32 (50%)   6/11 (55%)  14/16 (88%)   8/17 (47%) |
|FIRST INCIDENCE (DAYS) |   528          562          562          627       |   523          480          600          501       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.013N*    P=0.378      P=0.024 *    P=0.003N** |  P=0.357N     P=0.399      P=0.330      P=0.351N   |
|INCIDENTAL TUMOR       |  P=0.005N**   P=0.470N     P=0.368      P=0.002N** |  P=0.471      P=0.276N     P=0.207      P=0.479N   |
|LOGISTIC REGRESSION    |  P=0.005N**   P=0.543N     P=0.352      P=0.002N** |  P=0.513N     P=0.373N     P=0.207      P=0.438N   |
|COCHRAN-ARMITAGE       |  P=0.004N**                                        |  P=0.382                                           |
|FISHER EXACT           |               P=0.386N     P=0.523N     P=0.002N** |               P=0.350N     P=0.164      P=0.536    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/140 (4%)   2/70 (3%)    1/68 (1%)    1/70 (1%)  |                                                    |
|ADJUSTED (b)           |  21.1%        16.0%         5.6%         7.1%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |                                                    |
|TERMINAL (d)           |  4/20 (20%)   1/7 (14%)    0/1 (0%)     1/14 (7%)  |                                                    |
|FIRST INCIDENCE (DAYS) |   712          619          757          857 (T)   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.190N     P=0.646      P=0.603      P=0.219N   |                                                    |
|INCIDENTAL TUMOR       |  P=0.177N     P=0.658      P=0.655      P=0.228N   |                                                    |
|LOGISTIC REGRESSION    |  P=0.246N     P=0.661N     P=0.595N     P=0.318N   |                                                    |
|COCHRAN-ARMITAGE       |  P=0.211N                                          |                                                    |
|FISHER EXACT           |               P=0.571N     P=0.361N     P=0.348N   |                                                    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  19
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/140 (3%)   1/70 (1%)    0/68 (0%)    1/70 (1%)  |  1/140 (1%)   1/70 (1%)    0/68 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |  11.0%         6.3%         0.0%         2.0%      |   1.0%         4.2%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   759          773          ---          626       |   640          807          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.279N     P=0.570N     P=0.388N     P=0.414N   |  P=0.331N     P=0.581      P=0.630N     P=0.630N   |
|INCIDENTAL TUMOR       |  P=0.271N     P=0.451N     P=0.285N     P=0.441N   |  P=0.305N     P=0.639      P=0.682N     P=0.521N   |
|LOGISTIC REGRESSION    |  P=0.280N     P=0.508N     P=0.287N     P=0.448N   |  P=0.350N     P=0.598      P=0.645N     P=0.641N   |
|COCHRAN-ARMITAGE       |  P=0.257N                                          |  P=0.354N                                          |
|FISHER EXACT           |               P=0.459N     P=0.202N     P=0.459N   |               P=0.557      P=0.673N     P=0.667N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/140 (8%)   7/70 (10%)   4/68 (6%)    7/70 (10%) |  2/140 (1%)   1/70 (1%)    1/68 (1%)    2/70 (3%)  |
|ADJUSTED (b)           |  32.4%        45.6%        44.8%        25.7%      |   4.1%         4.2%         2.3%         9.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  5/20 (25%)   2/7 (29%)    0/1 (0%)     2/14 (14%) |  1/32 (3%)    0/11 (0%)    0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   667          634          535          626       |   640          807          703          856       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.447      P=0.192      P=0.230      P=0.490    |  P=0.376      P=0.689      P=0.728N     P=0.465    |
|INCIDENTAL TUMOR       |  P=0.413      P=0.302      P=0.499      P=0.412    |  P=0.380      P=0.731      P=0.719      P=0.502    |
|LOGISTIC REGRESSION    |  P=0.365      P=0.267      P=0.587      P=0.368    |  P=0.354      P=0.726      P=0.728      P=0.460    |
|COCHRAN-ARMITAGE       |  P=0.423                                           |  P=0.328                                           |
|FISHER EXACT           |               P=0.388      P=0.420N     P=0.388    |               P=0.742N     P=0.697      P=0.407    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  20
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/140 (8%)   8/70 (11%)   6/68 (9%)    6/70 (9%)  |  5/140 (4%)   3/70 (4%)    1/68 (1%)    1/70 (1%)  |
|ADJUSTED (b)           |  32.1%        61.8%        26.7%        26.7%      |   9.3%        13.5%         3.6%         4.2%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/20 (20%)   4/7 (57%)    0/1 (0%)     2/14 (14%) |  2/32 (6%)    1/11 (9%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   577          619          619          642       |   540          498          816          869       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.533      P=0.110      P=0.065      P=0.591N   |  P=0.167N     P=0.461      P=0.328N     P=0.298N   |
|INCIDENTAL TUMOR       |  P=0.540N     P=0.177      P=0.371      P=0.564    |  P=0.261N     P=0.513      P=0.365N     P=0.393N   |
|LOGISTIC REGRESSION    |  P=0.456      P=0.165      P=0.329      P=0.508    |  P=0.185N     P=0.545      P=0.334N     P=0.313N   |
|COCHRAN-ARMITAGE       |  P=0.515                                           |  P=0.198N                                          |
|FISHER EXACT           |               P=0.271      P=0.502      P=0.525    |               P=0.534      P=0.361N     P=0.348N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 14/140 (10%)  9/70 (13%)   7/68 (10%)   7/70 (10%) |  7/140 (5%)   3/70 (4%)    2/68 (3%)    3/70 (4%)  |
|ADJUSTED (b)           |  40.3%        63.3%        28.2%        29.3%      |  12.3%        13.5%         6.6%        15.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  5/20 (25%)   4/7 (57%)    0/1 (0%)     2/14 (14%) |  2/32 (6%)    1/11 (9%)    0/16 (0%)    2/17 (12%) |
|FIRST INCIDENCE (DAYS) |   577          619          562          642       |   540          498          789          869       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.491N     P=0.150      P=0.068      P=0.497N   |  P=0.363N     P=0.636N     P=0.351N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.480N     P=0.239      P=0.416      P=0.589N   |  P=0.502N     P=0.561N     P=0.376N     P=0.594N   |
|LOGISTIC REGRESSION    |  P=0.515      P=0.209      P=0.370      P=0.568    |  P=0.402N     P=0.553N     P=0.363N     P=0.511N   |
|COCHRAN-ARMITAGE       |  P=0.515N                                          |  P=0.434N                                          |
|FISHER EXACT           |               P=0.342      P=0.562      P=0.604N   |               P=0.559N     P=0.389N     P=0.559N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  21
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/140 (3%)   1/70 (1%)    1/68 (1%)    1/70 (1%)  |  1/140 (1%)   0/70 (0%)    1/68 (1%)    1/70 (1%)  |
|ADJUSTED (b)           |  11.9%         3.8%         2.0%         3.6%      |   2.3%         0.0%         3.1%         5.9%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   673          730          562          745       |   856          ---          789          898 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.336N     P=0.513N     P=0.695N     P=0.403N   |  P=0.427      P=0.678N     P=0.609      P=0.631    |
|INCIDENTAL TUMOR       |  P=0.352N     P=0.451N     P=0.514N     P=0.487N   |  P=0.389      P=0.607N     P=0.617      P=0.608    |
|LOGISTIC REGRESSION    |  P=0.344N     P=0.487N     P=0.516N     P=0.449N   |  P=0.413      P=0.663N     P=0.603      P=0.640    |
|COCHRAN-ARMITAGE       |  P=0.326N                                          |  P=0.377                                           |
|FISHER EXACT           |               P=0.459N     P=0.472N     P=0.459N   |               P=0.667N     P=0.548      P=0.557    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/140 (3%)   1/70 (1%)    1/68 (1%)    1/70 (1%)  |  2/140 (1%)   0/70 (0%)    1/68 (1%)    2/70 (3%)  |
|ADJUSTED (b)           |  11.9%         3.8%         2.0%         3.6%      |   3.3%         0.0%         3.1%        11.8%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    2/17 (12%) |
|FIRST INCIDENCE (DAYS) |   673          730          562          745       |   648          ---          789          898 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.336N     P=0.513N     P=0.695N     P=0.403N   |  P=0.320      P=0.424N     P=0.716N     P=0.464    |
|INCIDENTAL TUMOR       |  P=0.352N     P=0.451N     P=0.514N     P=0.487N   |  P=0.288      P=0.363N     P=0.709N     P=0.444    |
|LOGISTIC REGRESSION    |  P=0.344N     P=0.487N     P=0.516N     P=0.449N   |  P=0.300      P=0.404N     P=0.730      P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.326N                                          |  P=0.272                                           |
|FISHER EXACT           |               P=0.459N     P=0.472N     P=0.459N   |               P=0.443N     P=0.697      P=0.407    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  22
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |  0/140 (0%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |  10.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/20 (10%)   0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   857 (T)      ---          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.201N     P=0.488N     P=0.916N     P=0.318N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.201N     P=0.488N     P=0.916N     P=0.318N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.201N     P=0.488N     P=0.916N     P=0.318N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.198N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.443N     P=0.452N     P=0.443N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/140 (4%)   4/70 (6%)    4/68 (6%)    4/70 (6%)  |  1/140 (1%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |  18.2%        18.8%        44.8%        15.5%      |   3.1%         0.0%         2.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/20 (15%)   0/7 (0%)     0/1 (0%)     1/14 (7%)  |  1/32 (3%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   667          634          535          647       |   898 (T)      ---          703          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.386      P=0.315      P=0.061      P=0.520    |  P=0.527N     P=0.712N     P=0.596      P=0.626N   |
|INCIDENTAL TUMOR       |  P=0.351      P=0.402      P=0.209      P=0.452    |  P=0.525N     P=0.712N     P=0.608      P=0.626N   |
|LOGISTIC REGRESSION    |  P=0.346      P=0.387      P=0.271      P=0.435    |  P=0.523N     P=0.712N     P=0.600      P=0.627N   |
|COCHRAN-ARMITAGE       |  P=0.382                                           |  P=0.539N                                          |
|FISHER EXACT           |               P=0.441      P=0.423      P=0.441    |               P=0.667N     P=0.548      P=0.667N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  23
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/140 (2%)   2/70 (3%)    0/68 (0%)    2/70 (3%)  |  0/140 (0%)   0/70 (0%)    0/68 (0%)    2/70 (3%)  |
|ADJUSTED (b)           |  12.3%        28.6%         0.0%         9.7%      |   0.0%         0.0%         0.0%         9.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/20 (10%)   2/7 (29%)    0/1 (0%)     1/14 (7%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   795          857 (T)      ---          702       |   ---          ---          ---          856       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.555N     P=0.407      P=0.675N     P=0.640    |  P=0.035 *      (e)          (e)        P=0.128    |
|INCIDENTAL TUMOR       |  P=0.569N     P=0.449      P=0.571N     P=0.612    |  P=0.027 *      (e)          (e)        P=0.112    |
|LOGISTIC REGRESSION    |  P=0.550      P=0.430      P=0.475N     P=0.557    |  P=0.035 *      (e)          (e)        P=0.131    |
|COCHRAN-ARMITAGE       |  P=0.578                                           |  P=0.023 *                                         |
|FISHER EXACT           |               P=0.541      P=0.303N     P=0.541    |                 (e)          (e)        P=0.110    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/140 (6%)   6/70 (9%)    4/68 (6%)    6/70 (9%)  |  1/140 (1%)   0/70 (0%)    1/68 (1%)    2/70 (3%)  |
|ADJUSTED (b)           |  25.0%        42.0%        44.8%        24.2%      |   3.1%         0.0%         2.3%         9.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/20 (20%)   2/7 (29%)    0/1 (0%)     2/14 (14%) |  1/32 (3%)    0/11 (0%)    0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   667          634          535          647       |   898 (T)      ---          703          856       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.344      P=0.151      P=0.104      P=0.395    |  P=0.154      P=0.712N     P=0.596      P=0.303    |
|INCIDENTAL TUMOR       |  P=0.305      P=0.224      P=0.310      P=0.317    |  P=0.139      P=0.712N     P=0.608      P=0.283    |
|LOGISTIC REGRESSION    |  P=0.265      P=0.209      P=0.393      P=0.287    |  P=0.150      P=0.712N     P=0.600      P=0.324    |
|COCHRAN-ARMITAGE       |  P=0.312                                           |  P=0.126                                           |
|FISHER EXACT           |               P=0.305      P=0.593      P=0.305    |               P=0.667N     P=0.548      P=0.258    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  24
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/140 (6%)   6/70 (9%)    4/68 (6%)    6/70 (9%)  |  1/140 (1%)   0/70 (0%)    1/68 (1%)    2/70 (3%)  |
|ADJUSTED (b)           |  25.0%        42.0%        44.8%        24.2%      |   3.1%         0.0%         2.3%         9.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/20 (20%)   2/7 (29%)    0/1 (0%)     2/14 (14%) |  1/32 (3%)    0/11 (0%)    0/16 (0%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   667          634          535          647       |   898 (T)      ---          703          856       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.344      P=0.151      P=0.104      P=0.395    |  P=0.154      P=0.712N     P=0.596      P=0.303    |
|INCIDENTAL TUMOR       |  P=0.305      P=0.224      P=0.310      P=0.317    |  P=0.139      P=0.712N     P=0.608      P=0.283    |
|LOGISTIC REGRESSION    |  P=0.265      P=0.209      P=0.393      P=0.287    |  P=0.150      P=0.712N     P=0.600      P=0.324    |
|COCHRAN-ARMITAGE       |  P=0.312                                           |  P=0.126                                           |
|FISHER EXACT           |               P=0.305      P=0.593      P=0.305    |               P=0.667N     P=0.548      P=0.258    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/140 (2%)   1/70 (1%)    0/68 (0%)    1/70 (1%)  |  0/140 (0%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |   9.2%         6.3%         0.0%         2.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   759          773          ---          626       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.397N     P=0.700N     P=0.519N     P=0.544N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.387N     P=0.592N     P=0.407N     P=0.554N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.407N     P=0.645N     P=0.397N     P=0.582N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.384N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.593N     P=0.303N     P=0.593N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  25
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/140 (2%)   1/70 (1%)    0/68 (0%)    0/70 (0%)  |  0/140 (0%)   0/70 (0%)    0/67 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |   9.9%         2.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   795          564          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.142N     P=0.686N     P=0.573N     P=0.255N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.113N     P=0.602N     P=0.407N     P=0.278N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.128N     P=0.611N     P=0.432N     P=0.268N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.115N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.593N     P=0.303N     P=0.294N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    1/68 (1%)    1/70 (1%)  |  0/140 (0%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |   5.0%         0.0%         4.3%         2.3%      |   0.0%         0.0%         3.6%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   722          ---          729          647       |   ---          ---          816          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.552      P=0.455N     P=0.597      P=0.724    |  P=0.632        (e)        P=0.369        (e)      |
|INCIDENTAL TUMOR       |  P=0.505      P=0.392N     P=0.702      P=0.671    |  P=0.608        (e)        P=0.377        (e)      |
|LOGISTIC REGRESSION    |  P=0.564      P=0.435N     P=0.665      P=0.727    |  P=0.616        (e)        P=0.364        (e)      |
|COCHRAN-ARMITAGE       |  P=0.578                                           |  P=0.604                                           |
|FISHER EXACT           |               P=0.443N     P=0.697      P=0.742N   |                 (e)        P=0.327        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  26
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |113/140 (81%) 49/70 (70%)  56/67 (84%)  59/70 (84%) |                                                    |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |                                                    |
|TERMINAL (d)           | 20/20 (100%)  7/7 (100%)   1/1 (100%)  14/14 (100%)|                                                    |
|FIRST INCIDENCE (DAYS) |   489          535          464          487       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.270      P=0.359      P<0.001 **   P=0.510    |                                                    |
|INCIDENTAL TUMOR       |  P=0.031 *    P=0.025N*    P=0.071      P=0.124    |                                                    |
|LOGISTIC REGRESSION    |  P=0.018 *    P=0.042N*    P=0.047 *    P=0.109    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.195                                           |                                                    |
|FISHER EXACT           |               P=0.060N     P=0.385      P=0.333    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/140 (7%)   2/70 (3%)    2/68 (3%)    4/70 (6%)  | 13/139 (9%)   7/70 (10%)   7/67 (10%)   6/70 (9%)  |
|ADJUSTED (b)           |  25.1%        22.9%        10.9%        17.6%      |  30.0%        28.1%        21.8%        24.2%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/20 (10%)   1/7 (14%)    0/1 (0%)     2/14 (14%) |  7/32 (22%)   0/11 (0%)    1/16 (6%)    3/17 (18%) |
|FIRST INCIDENCE (DAYS) |   715          831          691          603       |   540          669          649          633       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.365N     P=0.317N     P=0.558N     P=0.399N   |  P=0.364N     P=0.354      P=0.572      P=0.448N   |
|INCIDENTAL TUMOR       |  P=0.383N     P=0.192N     P=0.322N     P=0.455N   |  P=0.469N     P=0.510      P=0.537      P=0.517N   |
|LOGISTIC REGRESSION    |  P=0.413N     P=0.250N     P=0.339N     P=0.484N   |  P=0.414N     P=0.476      P=0.542      P=0.451N   |
|COCHRAN-ARMITAGE       |  P=0.365N                                          |  P=0.492N                                          |
|FISHER EXACT           |               P=0.173N     P=0.186N     P=0.473N   |               P=0.530      P=0.491      P=0.537N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  27
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/140 (1%)   1/70 (1%)    0/68 (0%)    2/70 (3%)  |  3/139 (2%)   0/70 (0%)    2/67 (3%)    1/70 (1%)  |
|ADJUSTED (b)           |   5.0%         2.4%         0.0%         9.7%      |   7.5%         0.0%        12.5%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     1/14 (7%)  |  2/32 (6%)    0/11 (0%)    2/16 (13%)   0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   857 (T)      667          ---          702       |   744          ---          898 (T)      888       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.245      P=0.544      P=0.983N     P=0.334    |  P=0.512N     P=0.339N     P=0.570      P=0.525N   |
|INCIDENTAL TUMOR       |  P=0.229      P=0.562      P=0.983N     P=0.314    |  P=0.538N     P=0.312N     P=0.571      P=0.556N   |
|LOGISTIC REGRESSION    |  P=0.200      P=0.572      P=0.983N     P=0.260    |  P=0.499N     P=0.291N     P=0.584      P=0.523N   |
|COCHRAN-ARMITAGE       |  P=0.209                                           |  P=0.566N                                          |
|FISHER EXACT           |               P=0.557      P=0.673N     P=0.258    |               P=0.292N     P=0.524      P=0.590N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/140 (8%)   3/70 (4%)    2/68 (3%)    6/70 (9%)  | 15/139 (11%)  7/70 (10%)   9/67 (13%)   7/70 (10%) |
|ADJUSTED (b)           |  29.3%        24.7%        10.9%        26.5%      |  33.6%        28.1%        32.2%        27.6%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/20 (15%)   1/7 (14%)    0/1 (0%)     3/14 (21%) |  8/32 (25%)   0/11 (0%)    3/16 (19%)   3/17 (18%) |
|FIRST INCIDENCE (DAYS) |   715          667          691          603       |   540          669          649          633       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.549N     P=0.429N     P=0.543N     P=0.584N   |  P=0.396N     P=0.465      P=0.450      P=0.434N   |
|INCIDENTAL TUMOR       |  P=0.528      P=0.282N     P=0.312N     P=0.564    |  P=0.508N     P=0.563N     P=0.413      P=0.512N   |
|LOGISTIC REGRESSION    |  P=0.488      P=0.347N     P=0.300N     P=0.509    |  P=0.446N     P=0.593N     P=0.420      P=0.441N   |
|COCHRAN-ARMITAGE       |  P=0.542                                           |  P=0.538N                                          |
|FISHER EXACT           |               P=0.253N     P=0.141N     P=0.525    |               P=0.533N     P=0.367      P=0.533N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  28
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/140 (0%)   0/70 (0%)    0/68 (0%)    3/70 (4%)  |  2/139 (1%)   0/70 (0%)    1/67 (1%)    2/70 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        18.8%      |   6.3%         0.0%         6.3%         7.8%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     1/14 (7%)  |  2/32 (6%)    0/11 (0%)    1/16 (6%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          810       |   898 (T)      ---          898 (T)      673       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.011 *      (e)          (e)        P=0.047 *  |  P=0.306      P=0.492N     P=0.734      P=0.451    |
|INCIDENTAL TUMOR       |  P=0.005 **     (e)          (e)        P=0.028 *  |  P=0.302      P=0.492N     P=0.734      P=0.448    |
|LOGISTIC REGRESSION    |  P=0.006 **     (e)          (e)        P=0.032 *  |  P=0.318      P=0.492N     P=0.734      P=0.469    |
|COCHRAN-ARMITAGE       |  P=0.004 **                                        |  P=0.274                                           |
|FISHER EXACT           |                 (e)          (e)        P=0.036 *  |               P=0.441N     P=0.695      P=0.410    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/140 (0%)   1/70 (1%)    1/68 (1%)    3/70 (4%)  |  2/139 (1%)   0/70 (0%)    2/67 (3%)    2/70 (3%)  |
|ADJUSTED (b)           |   0.0%        14.3%        12.5%        18.8%      |   6.3%         0.0%        10.9%         7.8%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    1/7 (14%)    0/1 (0%)     1/14 (7%)  |  2/32 (6%)    0/11 (0%)    1/16 (6%)    1/17 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          857 (T)      806          810       |   898 (T)      ---          888          673       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.036 *    P=0.291      P=0.190      P=0.047 *  |  P=0.283      P=0.492N     P=0.445      P=0.451    |
|INCIDENTAL TUMOR       |  P=0.021 *    P=0.291      P=0.337      P=0.028 *  |  P=0.262      P=0.492N     P=0.436      P=0.448    |
|LOGISTIC REGRESSION    |  P=0.021 *    P=0.291      P=0.250      P=0.032 *  |  P=0.287      P=0.492N     P=0.471      P=0.469    |
|COCHRAN-ARMITAGE       |  P=0.018 *                                         |  P=0.237                                           |
|FISHER EXACT           |               P=0.333      P=0.327      P=0.036 *  |               P=0.441N     P=0.393      P=0.410    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  29
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |  0/140 (0%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |   3.5%         0.0%         0.0%         0.0%      |   0.0%         0.0%         1.9%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   719          ---          ---          ---       |   ---          ---          613          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.229N     P=0.471N     P=0.526N     P=0.420N   |  P=0.614        (e)        P=0.368        (e)      |
|INCIDENTAL TUMOR       |  P=0.225N     P=0.392N     P=0.431N     P=0.462N   |  P=0.669        (e)        P=0.318        (e)      |
|LOGISTIC REGRESSION    |  P=0.211N     P=0.422N     P=0.457N     P=0.407N   |  P=0.602        (e)        P=0.354        (e)      |
|COCHRAN-ARMITAGE       |  P=0.198N                                          |  P=0.604                                           |
|FISHER EXACT           |               P=0.443N     P=0.452N     P=0.443N   |                 (e)        P=0.327        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    0/68 (0%)    2/70 (3%)  |  1/140 (1%)   1/70 (1%)    2/68 (3%)    0/70 (0%)  |
|ADJUSTED (b)           |   3.5%         0.0%         0.0%         9.3%      |   3.1%         6.7%         8.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     1/14 (7%)  |  1/32 (3%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   719          ---          ---          647       |   898 (T)      873          613          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.321      P=0.471N     P=0.526N     P=0.439    |  P=0.511N     P=0.528      P=0.272      P=0.626N   |
|INCIDENTAL TUMOR       |  P=0.291      P=0.392N     P=0.431N     P=0.393    |  P=0.494N     P=0.576      P=0.247      P=0.626N   |
|LOGISTIC REGRESSION    |  P=0.306      P=0.422N     P=0.457N     P=0.419    |  P=0.527N     P=0.552      P=0.270      P=0.627N   |
|COCHRAN-ARMITAGE       |  P=0.318                                           |  P=0.555N                                          |
|FISHER EXACT           |               P=0.443N     P=0.452N     P=0.407    |               P=0.557      P=0.250      P=0.667N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  30
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/140 (0%)   0/70 (0%)    0/68 (0%)    2/70 (3%)  |  1/140 (1%)   1/70 (1%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         9.3%      |   3.1%         6.7%         6.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     1/14 (7%)  |  1/32 (3%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          647       |   898 (T)      873          898 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.038 *      (e)          (e)        P=0.125    |  P=0.430N     P=0.528      P=0.600      P=0.626N   |
|INCIDENTAL TUMOR       |  P=0.033 *      (e)          (e)        P=0.113    |  P=0.451N     P=0.576      P=0.600      P=0.626N   |
|LOGISTIC REGRESSION    |  P=0.024 *      (e)          (e)        P=0.100    |  P=0.410N     P=0.552      P=0.600      P=0.627N   |
|COCHRAN-ARMITAGE       |  P=0.023 *                                         |  P=0.471N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.110    |               P=0.557      P=0.548      P=0.667N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    | 16/140 (11%) 12/70 (17%)   5/68 (7%)    9/70 (13%) |
|ADJUSTED (b)           |                                                    |  27.7%        38.8%        19.2%        24.8%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  4/32 (13%)   1/11 (9%)    0/16 (0%)    2/17 (12%) |
|FIRST INCIDENCE (DAYS) |                                                    |   633          576          425          591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.386N     P=0.105      P=0.221N     P=0.556    |
|INCIDENTAL TUMOR       |                                                    |  P=0.402N     P=0.228      P=0.224N     P=0.584N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.506N     P=0.160      P=0.231N     P=0.514    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.515N                                          |
|FISHER EXACT           |                                                    |               P=0.175      P=0.256N     P=0.462    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  31
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  3/140 (2%)   1/70 (1%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |                                                    |   4.1%         2.3%         6.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  0/32 (0%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   302          669          898 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.172N     P=0.592N     P=0.564N     P=0.250N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.218N     P=0.679N     P=0.620N     P=0.326N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.185N     P=0.570N     P=0.582N     P=0.274N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.185N                                          |
|FISHER EXACT           |                                                    |               P=0.593N     P=0.604N     P=0.294N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    | 18/140 (13%) 13/70 (19%)   6/68 (9%)    9/70 (13%) |
|ADJUSTED (b)           |                                                    |  29.9%        40.2%        24.2%        24.8%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  4/32 (13%)   1/11 (9%)    1/16 (6%)    2/17 (12%) |
|FIRST INCIDENCE (DAYS) |                                                    |   302          576          425          591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.291N     P=0.114      P=0.233N     P=0.492N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.334N     P=0.201      P=0.248N     P=0.524N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.403N     P=0.173      P=0.247N     P=0.549N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.407N                                          |
|FISHER EXACT           |                                                    |               P=0.185      P=0.271N     P=0.593N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  32
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/140 (2%)   1/70 (1%)    3/68 (4%)    3/70 (4%)  |  0/140 (0%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |   8.2%         1.9%        16.3%         7.8%      |   0.0%         0.0%         6.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   500          554          642          487       |   ---          ---          898 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.184      P=0.648N     P=0.096      P=0.334    |  P=0.616        (e)        P=0.362        (e)      |
|INCIDENTAL TUMOR       |  P=0.222      P=0.583N     P=0.311      P=0.366    |  P=0.616        (e)        P=0.362        (e)      |
|LOGISTIC REGRESSION    |  P=0.190      P=0.581N     P=0.265      P=0.327    |  P=0.616        (e)        P=0.362        (e)      |
|COCHRAN-ARMITAGE       |  P=0.194                                           |  P=0.604                                           |
|FISHER EXACT           |               P=0.593N     P=0.305      P=0.318    |                 (e)        P=0.327        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/140 (2%)   1/70 (1%)    3/68 (4%)    4/70 (6%)  |  0/140 (0%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |   8.2%         1.9%        16.3%        10.4%      |   0.0%         0.0%         6.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    1/16 (6%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   500          554          642          487       |   ---          ---          898 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.085      P=0.648N     P=0.096      P=0.173    |  P=0.616        (e)        P=0.362        (e)      |
|INCIDENTAL TUMOR       |  P=0.097      P=0.583N     P=0.311      P=0.181    |  P=0.616        (e)        P=0.362        (e)      |
|LOGISTIC REGRESSION    |  P=0.085      P=0.581N     P=0.265      P=0.168    |  P=0.616        (e)        P=0.362        (e)      |
|COCHRAN-ARMITAGE       |  P=0.088                                           |  P=0.604                                           |
|FISHER EXACT           |               P=0.593N     P=0.305      P=0.170    |                 (e)        P=0.327        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  33
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    0/68 (0%)    1/70 (1%)  |  0/140 (0%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |  10.0%         0.0%         0.0%         7.1%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/20 (10%)   0/7 (0%)     0/1 (0%)     1/14 (7%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   857 (T)      ---          ---          857 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.547N     P=0.488N     P=0.916N     P=0.626N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.547N     P=0.488N     P=0.916N     P=0.626N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.547N     P=0.488N     P=0.916N     P=0.626N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.623N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.443N     P=0.452N     P=0.742N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/140 (1%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |  1/140 (1%)   0/70 (0%)    0/68 (0%)    1/70 (1%)  |
|ADJUSTED (b)           |   3.0%         0.0%         0.0%         0.0%      |   3.1%         0.0%         0.0%         3.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  1/32 (3%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   626          ---          ---          ---       |   898 (T)      ---          ---          841       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.214N     P=0.436N     P=0.497N     P=0.399N   |  P=0.500      P=0.712N     P=0.638N     P=0.632    |
|INCIDENTAL TUMOR       |  P=0.177N     P=0.405N     P=0.326N     P=0.393N   |  P=0.475      P=0.712N     P=0.638N     P=0.608    |
|LOGISTIC REGRESSION    |  P=0.204N     P=0.410N     P=0.427N     P=0.404N   |  P=0.500      P=0.712N     P=0.638N     P=0.636    |
|COCHRAN-ARMITAGE       |  P=0.198N                                          |  P=0.461                                           |
|FISHER EXACT           |               P=0.443N     P=0.452N     P=0.443N   |               P=0.667N     P=0.673N     P=0.557    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  34
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/140 (3%)   0/70 (0%)    0/68 (0%)    1/70 (1%)  |  1/140 (1%)   0/70 (0%)    0/68 (0%)    1/70 (1%)  |
|ADJUSTED (b)           |  12.7%         0.0%         0.0%         7.1%      |   3.1%         0.0%         0.0%         3.4%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/20 (10%)   0/7 (0%)     0/1 (0%)     1/14 (7%)  |  1/32 (3%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   626          ---          ---          857 (T)   |   898 (T)      ---          ---          841       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.261N     P=0.242N     P=0.442N     P=0.351N   |  P=0.500      P=0.712N     P=0.638N     P=0.632    |
|INCIDENTAL TUMOR       |  P=0.243N     P=0.226N     P=0.294N     P=0.348N   |  P=0.475      P=0.712N     P=0.638N     P=0.608    |
|LOGISTIC REGRESSION    |  P=0.305N     P=0.215N     P=0.263N     P=0.449N   |  P=0.500      P=0.712N     P=0.638N     P=0.636    |
|COCHRAN-ARMITAGE       |  P=0.276N                                          |  P=0.461                                           |
|FISHER EXACT           |               P=0.195N     P=0.202N     P=0.459N   |               P=0.667N     P=0.673N     P=0.557    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 84/140 (60%) 47/70 (67%)  40/68 (59%)  32/70 (46%) | 52/140 (37%) 33/70 (47%)  22/68 (32%)  27/70 (39%) |
|ADJUSTED (b)           |  87.8%        97.2%       100.0%        75.2%      |  66.4%        79.3%        51.6%        63.2%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           | 11/20 (55%)   6/7 (86%)    1/1 (100%)   6/14 (43%) | 12/32 (38%)   4/11 (36%)   2/16 (13%)   5/17 (29%) |
|FIRST INCIDENCE (DAYS) |   375          394          464          423       |   421          481          197          501       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.156N     P=0.043 *    P=0.006 **   P=0.090N   |  P=0.249N     P=0.045 *    P=0.257N     P=0.420N   |
|INCIDENTAL TUMOR       |  P=0.032N*    P=0.121      P=0.533      P=0.052N   |  P=0.491N     P=0.158      P=0.267N     P=0.465    |
|LOGISTIC REGRESSION    |  P=0.013N*    P=0.091      P=0.529N     P=0.026N*  |  P=0.425N     P=0.142      P=0.292N     P=0.553    |
|COCHRAN-ARMITAGE       |  P=0.023N*                                         |  P=0.467N                                          |
|FISHER EXACT           |               P=0.196      P=0.494N     P=0.035N*  |               P=0.107      P=0.302N     P=0.478    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  35
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/140 (1%)   0/70 (0%)    1/68 (1%)    3/70 (4%)  |  1/140 (1%)   0/70 (0%)    0/68 (0%)    0/70 (0%)  |
|ADJUSTED (b)           |   5.0%         0.0%         6.3%         7.2%      |   0.9%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/20 (5%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   857 (T)      ---          761          626       |   380          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.046 *    P=0.709N     P=0.330      P=0.121    |  P=0.393N     P=0.633N     P=0.643N     P=0.633N   |
|INCIDENTAL TUMOR       |  P=0.037 *    P=0.709N     P=0.387      P=0.115    |  P=0.605N     P=0.638N     P=0.814N     P=0.923N   |
|LOGISTIC REGRESSION    |  P=0.034 *    P=0.709N     P=0.460      P=0.102    |  P=0.403N     P=0.642N     P=0.647N     P=0.652N   |
|COCHRAN-ARMITAGE       |  P=0.035 *                                         |  P=0.396N                                          |
|FISHER EXACT           |               P=0.667N     P=0.548      P=0.109    |               P=0.667N     P=0.673N     P=0.667N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/140 (0%)   0/70 (0%)    2/68 (3%)    0/70 (0%)  |  0/140 (0%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.2%         0.0%      |   0.0%         0.0%         3.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          501          ---       |   ---          ---          788          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.453        (e)        P=0.082        (e)      |  P=0.625        (e)        P=0.365        (e)      |
|INCIDENTAL TUMOR       |  P=0.559        (e)        P=0.240        (e)      |  P=0.608        (e)        P=0.377        (e)      |
|LOGISTIC REGRESSION    |  P=0.464        (e)        P=0.106        (e)      |  P=0.612        (e)        P=0.361        (e)      |
|COCHRAN-ARMITAGE       |  P=0.461                                           |  P=0.604                                           |
|FISHER EXACT           |                 (e)        P=0.106        (e)      |                 (e)        P=0.327        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  36
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/140 (0%)   0/70 (0%)    2/68 (3%)    0/70 (0%)  |  0/140 (0%)   0/70 (0%)    1/68 (1%)    0/70 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.2%         0.0%      |   0.0%         0.0%         3.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/20 (0%)    0/7 (0%)     0/1 (0%)     0/14 (0%)  |  0/32 (0%)    0/11 (0%)    0/16 (0%)    0/17 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          501          ---       |   ---          ---          788          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.453        (e)        P=0.082        (e)      |  P=0.625        (e)        P=0.365        (e)      |
|INCIDENTAL TUMOR       |  P=0.559        (e)        P=0.240        (e)      |  P=0.608        (e)        P=0.377        (e)      |
|LOGISTIC REGRESSION    |  P=0.464        (e)        P=0.106        (e)      |  P=0.612        (e)        P=0.361        (e)      |
|COCHRAN-ARMITAGE       |  P=0.461                                           |  P=0.604                                           |
|FISHER EXACT           |                 (e)        P=0.106        (e)      |                 (e)        P=0.327        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |119/140 (85%) 56/70 (80%)  56/68 (82%)  59/70 (84%) | 97/140 (69%) 51/70 (73%)  49/68 (72%)  50/70 (71%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  94.9%       100.0%        96.0%        95.8%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           | 20/20 (100%)  7/7 (100%)   1/1 (100%)  14/14 (100%)| 27/32 (84%)  11/11 (100%) 14/16 (88%)  15/17 (88%) |
|FIRST INCIDENCE (DAYS) |   381          535          464          487       |   418          480          425          501       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.434      P=0.187      P<0.001 **   P=0.424N   |  P=0.245N     P=0.097      P=0.495N     P=0.336N   |
|INCIDENTAL TUMOR       |  P=0.583      P=0.127N     P=0.407N     P=0.702N   |  P=0.426N     P=0.432      P=0.567      P=0.382N   |
|LOGISTIC REGRESSION    |  P=0.479N     P=0.144N     P=0.395N     P=0.433N   |  P=0.443N     P=0.329      P=0.505      P=0.497N   |
|COCHRAN-ARMITAGE       |  P=0.500N                                          |  P=0.405                                           |
|FISHER EXACT           |               P=0.234N     P=0.381N     P=0.521N   |               P=0.357      P=0.405      P=0.439    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  37
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |102/140 (73%) 53/70 (76%)  50/68 (74%)  47/70 (67%) | 73/140 (52%) 39/70 (56%)  38/68 (56%)  39/70 (56%) |
|ADJUSTED (b)           |  94.7%        97.8%       100.0%        91.2%      |  80.8%        84.9%        82.2%        82.8%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           | 15/20 (75%)   6/7 (86%)    1/1 (100%)  10/14 (71%) | 18/32 (56%)   5/11 (45%)   9/16 (56%)  10/17 (59%) |
|FIRST INCIDENCE (DAYS) |   375          289          464          423       |   302          481          197          501       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.434N     P=0.083      P=0.001 **   P=0.289N   |  P=0.373N     P=0.152      P=0.509      P=0.461N   |
|INCIDENTAL TUMOR       |  P=0.175N     P=0.390      P=0.527N     P=0.223N   |  P=0.261      P=0.449      P=0.322      P=0.267    |
|LOGISTIC REGRESSION    |  P=0.130N     P=0.320      P=0.499N     P=0.186N   |  P=0.372      P=0.473      P=0.334      P=0.423    |
|COCHRAN-ARMITAGE       |  P=0.214N                                          |  P=0.332                                           |
|FISHER EXACT           |               P=0.394      P=0.529      P=0.241N   |               P=0.366      P=0.360      P=0.366    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |120/140 (86%) 59/70 (84%)  57/68 (84%)  60/70 (86%) |113/140 (81%) 59/70 (84%)  56/68 (82%)  59/70 (84%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  96.6%       100.0%        98.2%        98.3%      |
|INTERIM SACRIFICE 1 (c)|  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/20 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           | 20/20 (100%)  7/7 (100%)   1/1 (100%)  14/14 (100%)| 28/32 (88%)  11/11 (100%) 15/16 (94%)  16/17 (94%) |
|FIRST INCIDENCE (DAYS) |   375          289          464          423       |   302          480          197          501       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.424      P=0.119      P<0.001 **   P=0.448N   |  P=0.267N     P=0.105      P=0.445N     P=0.370N   |
|INCIDENTAL TUMOR       |  P=0.629      P=0.406N     P=0.500N       (e)      |  P=0.213      P=0.417      P=0.463      P=0.379    |
|LOGISTIC REGRESSION    |  P=0.536N     P=0.745N     P=0.281N       (e)      |  P=0.171      P=0.436      P=0.309      P=0.325    |
|COCHRAN-ARMITAGE       |  P=0.525N                                          |  P=0.313                                           |
|FISHER EXACT           |               P=0.466N     P=0.433N     P=0.576N   |               P=0.333      P=0.468      P=0.333    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05217 TEST: 03                                                 PAGE  38
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE

                                                 MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 129 WEEKS
                                                                           

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   92
          Female interim sacrifices(days): 93
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).