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TDMS Study 05217-03 Pathology Tables


                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                        T-BUTYLHYDROQUINONE


NTP Experiment-Test: 05217-03                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 03/30/95
Route: DOSED FEED                                                                                                 Time: 22:28:16


                                                      LIFETIME CORE STUDY


       Facility:  Southern Research Institute

       Chemical CAS #:  1948-33-0

       Lock Date:  05/26/93

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    UNTREATD CONTROL
                               Include 002    UNTREATD CONTROL
                               Include 003    0.125%
                               Include 004    0.125%
                               Include 005    0.25%
                               Include 006    0.25%
                               Include 007    0.5%
                               Include 008    0.5%

























                                                             Page   1

NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|             
                                           | 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X  X           X              X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                1        1           2  1  1  4                       2  3|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                     3              3                 3   |             
      Hematopoietic Cell Proliferation     |                   1                                                      |             
      Hepatodiaphragmatic Nodule           |                X           X                                X            |             
      Inflammation, Granulomatous          |                      2  1              1           2     3               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      | 4     1     1                                                            |             
      Bile Duct, Hyperplasia               |    1     1              1                 1     1                       3|             
      Hepatocyte, Vacuolization Cytoplasmic|    2  3  3                       4        2                    3  2     3|             
      Kupffer Cell, Pigmentation           |       3              2           3        1           2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +        +  +           +                       +      |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |                            3  2           2                       2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                       3  1        1        1              2  1|             
      Metaplasia, Hepatocyte               |                                                       2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                                                  1                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       4                                                           3      |             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |       3  3                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               2                                          |             
      Erosion                              |                   2                       2                              |             
      Ulcer                                |                                                             2            |             
                                            __________________________________________________________________________|             
   Tongue                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|             
                                           | 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2           3  2     1     2     2  3     3  1           2     3|             
      Thrombosis                           |       3                                                                  |             
      Valve, Inflammation, Chronic         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    2     1                                                               |             
      Atrophy                              |                      4                                                   |             
      Degeneration, Fatty                  |                1              4                                2         |             
      Hemorrhage                           |                               3                                          |             
      Hyperplasia, Diffuse                 |                      3                                                   |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   | 2  2                                         2                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                        2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  4                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   2        2     3        4                              |             
      Pars Distalis, Cyst                  | 3                       3                       3     3        3         |             
      Pars Distalis, Hyperplasia, Focal    |                      2                          3  3  1                  |             
      Pars Intermedia, Cyst                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |          2           1        1                             1            |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            3                 3                           |             
      Cyst, Multiple                       | 2                                                                        |             
      Hyperplasia                          |       3                                                                 3|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |       2           1                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3     3                       3  3     3     3  3              3|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|             
                                           | 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |          M                       M        M        M              M      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Hyperplasia                          |                   3                                                      |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +        +  +                          +        +        +      |             
      Mediastinal, Ectasia                 |       3                                                                  |             
      Mediastinal, Hemorrhage              |                   4                                               3      |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                   3      |             
      Mediastinal, Pigmentation            |       3  3           3                          3        4        3      |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2                                                         |             
      Hemorrhage                           |                                     1                                    |             
      Hyperplasia, Lymphoid                |                               3        2                          2      |             
      Hyperplasia, Plasma Cell             |                                                          3               |             
      Pigmentation                         |          2  2  2     2     2        2  3                          2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Ectasia                              |                         3                                                |             
      Hyperplasia, Lymphoid                |                         2                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                3  4     2  2  2        1     2           3        3  1   |             
      Pigmentation, Hemosiderin            |                2        2  2  2        2  2  2     2              3  2   |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       2  3        2     1  2  3  1     3  3        2  2  2     2     2   |             
      Galactocele                          |                      2              4        4                           |             
      Hyperplasia                          |    3           2                    2                       2     1     2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                            X                                             |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|             
                                           | 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               | 2     3                                                     3        3   |             
      Femur, Osteopetrosis                 | 3     3                          3                       2  2        3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4     3                    3     3     3              2     3         |             
      Hydrocephalus                        |                                        2                                 |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                             +            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                                                            |             
      Hemorrhage                           |       4                                                                  |             
      Infiltration Cellular, Histiocyte    |    1  3              1  1     1  1  1  1  1        1  1  1     1         |             
      Inflammation, Subacute               |       3                          3                                       |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2  3                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                X                                                         |             
      Inflammation, Suppurative            |                                                          3               |             
      Goblet Cell, Hyperplasia             |    1                 1     1                    2                        |             
      Mucosa, Hyperplasia                  |                                                          2               |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +     +     +                  |             
      Cataract                             |                                                 2     3                  |             
      Hemorrhage                           |                                           2                              |             
      Retina, Degeneration                 |                                           3     3     4                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                      1           3                                       |             
      Mineralization                       | 3  3  3  2  3  3  2  3  2  2  3  1  2  3  3  2  2     3  3  2  2  1  3  3|             
      Nephropathy                          |    3  1                       3  1  3  2  1  1           1     1  1     2|             
      Renal Tubule, Atrophy                |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|             
                                           | 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |    3                                      3                              |             
      Renal Tubule, Necrosis               | 3                                3                                       |             
      Renal Tubule, Pigmentation           | 2     2  2              3        2                    3                  |             
      Transitional Epithelium, Hyperplasia |                      1                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   6                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|             
                             DAY ON TEST   | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|             
                                           | 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                            2                                             |             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                                      |             
      Basophilic Focus                     |    3  1  1        4              2           3  3        1  3     3      |             
      Clear Cell Focus                     |    4                                                                     |             
      Degeneration, Cystic                 |                               1                                          |             
      Eosinophilic Focus                   |                   3        3                                      4      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X              X           X                    X     X     X        X|             
      Inflammation, Granulomatous          |          1                          2        1                           |             
      Mixed Cell Focus                     |                                     3                                   4|             
      Necrosis, Focal                      |                                                          1               |             
      Bile Duct, Hyperplasia               | 2        1  2           2     2        2  2        2  3                 1|             
      Hepatocyte, Vacuolization Cytoplasmic|                      4                 3           3  3        4         |             
      Kupffer Cell, Pigmentation           |             2        3  3                 2           2        3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +  +                    +     +                                 |             
      Accessory Spleen                     |             X                                                            |             
      Fat, Necrosis                        |    3     3                       2     3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1  1        2  4  2  1              1     2        1      |             
      Metaplasia, Hepatocyte               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    2           4         |             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                4         |             
      Mucosa, Hyperplasia                  |                                                                3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                      3   |             
      Ulcer                                |    4                                                                     |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   7                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|             
                             DAY ON TEST   | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|             
                                           | 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                2  1     2  3     3  2  2           1  2     2  3  2     2|             
      Thrombosis                           |                      4  3                                                |             
      Valve, Inflammation, Chronic         |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   3           2  1                 1           1  3      |             
      Atrophy                              |                                                                          |             
      Degeneration, Fatty                  |                               2           3                              |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Diffuse                 |                                                                      3   |             
      Hyperplasia, Focal                   |    2                             3           2                           |             
      Hypertrophy, Focal                   |                               2                             1     3      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2  1                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                      3                    2                              |             
      Pars Distalis, Cyst                  | 3                             3              3  3     2           3  3   |             
      Pars Distalis, Hyperplasia, Focal    |          2           3                       3                    2      |             
      Pars Intermedia, Cyst                |                                           3                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                         3                                                |             
      C-Cell, Hyperplasia                  |    1                             1  1              1                     |             
      Follicle, Cyst                       |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Hyperplasia                          |    2                                                                     |             
      Inflammation, Chronic                |    2                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3     3  3        3  3           3                 3                    3|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   8                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|             
                             DAY ON TEST   | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|             
                                           | 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                             2            |             
      Hyperplasia, Cystic                  |    1                                            2                        |             
                                            __________________________________________________________________________|             
   Vagina                                  |    M                    M              M                       M         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |    3                                                                     |             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                        2  2                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +           +  +  +        +  +     +  +                 +   |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                            2                                             |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |             2           3  3                    2                    4   |             
      Pancreatic, Pigmentation             |                         3                                                |             
      Renal, Pigmentation                  |                                                    4                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2                                                            |             
      Hemorrhage                           |    2                                                                     |             
      Hyperplasia, Lymphoid                |       3           2  2              2        2                 2        2|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |                2           2     2  2           2     2     3  2        2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               2                    3                     |             
      Hematopoietic Cell Proliferation     |       2        1                                1                        |             
      Pigmentation, Hemosiderin            |    3           2  2  3           3  3        3  2           2  3        3|             
      Lymphoid Follicle, Atrophy           |                                                                      4   |             
      Red Pulp, Atrophy                    |                      3                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2     2     2  2  2  3     2  2     3  1  3     2  2     1           2   |             
      Galactocele                          |                                                                         4|             
      Hyperplasia                          |    3                             2           3        3     2     2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                           3                              |             
      Inflammation, Chronic                |                                     3                                    |             
      Epidermis, Hyperplasia               |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|             
                             DAY ON TEST   | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|             
                                           | 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                   3                                         3  3         |             
      Femur, Osteopetrosis                 |                                                                3         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3           3           4     4  4     3                 4  4        3|             
      Hydrocephalus                        |                            2                                2            |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           | 3                                                                        |             
      Infiltration Cellular, Histiocyte    | 3  1              1  1        2     1        1     3              1     1|             
      Inflammation, Subacute               |                                                       4                  |             
      Thrombosis                           |                      2                                                   |             
      Alveolar Epithelium, Hyperplasia     |                      1        3                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         X           X                                    |             
      Inflammation, Suppurative            |    2                    3           2                                    |             
      Goblet Cell, Hyperplasia             |    1              1                    1     1              1            |             
      Mucosa, Hyperplasia                  |    1                    3           3                                    |             
      Mucosa, Metaplasia, Squamous         |    2                    2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Cataract                             |                                           4                              |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   2                                                      |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 2  2  1  2  2  2  2  1  2  3  2  3  3  2  3  3  3  3  2  2     3  3  2  2|             
      Nephropathy                          |    2  1        1  3     1  2     2  3  1  1  1     1  1     3  2  1     3|             
      Renal Tubule, Atrophy                |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|             
                             DAY ON TEST   | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|             
                                           | 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                2           2                                             |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |             2           1        1     3           4  3              3  2|             
      Transitional Epithelium, Hyperplasia |                                              1                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 7| 8| 8| 8| 8| 8| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8|                                            |            |
                                           | 8| 8| 5| 3| 6| 8| 8| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  I  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |       X                                                                  |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                   X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    | X                 X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | 3  3     3  1  3  4  3  4                                                |     26  2.4|
      Clear Cell Focus                     | 1                                                                        |      2  2.5|
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   | 2           3        2  2                                                |     10  2.8|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |       X           X                                                      |     12     |
      Inflammation, Granulomatous          |       2  1        3     1                                                |     12  1.7|
      Mixed Cell Focus                     |                                                                          |      2  3.5|
      Necrosis, Focal                      |    2           1                                                         |      6  1.7|
      Bile Duct, Hyperplasia               |                            2                                             |     17  1.7|
      Hepatocyte, Vacuolization Cytoplasmic|                            3                                             |     14  3.0|
      Kupffer Cell, Pigmentation           |       1                                                                  |     12  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |  11        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |                      3                                                   |      9  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              | 1  2           2  2                                                      |     20  1.6|
      Metaplasia, Hepatocyte               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      4  3.3|
      Erosion                              |                   2                                                      |      1  2.0|
      Ulcer                                |       2                                                                  |      2  3.0|
      Mucosa, Hyperplasia                  |       3           2                                                      |      5  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  12                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 7| 8| 8| 8| 8| 8| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8|                                            |            |
                                           | 8| 8| 5| 3| 6| 8| 8| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      3  2.3|
      Ulcer                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |    2  2                    2                                             |     28  2.1|
      Thrombosis                           |                                                                          |      3  3.3|
      Valve, Inflammation, Chronic         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    | 1                       2  3                                             |     11  1.8|
      Atrophy                              |                                                                          |      1  4.0|
      Degeneration, Fatty                  |    1  1     3              1                                             |      9  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Diffuse                 |             3                                                            |      3  3.0|
      Hyperplasia, Focal                   |                                                                          |      3  2.3|
      Hypertrophy, Focal                   |       1     3        2                                                   |      9  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |             3                                                            |      5  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +                                             |  52        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                4           4                                             |      8  3.0|
      Pars Distalis, Cyst                  |    3                    3                                                |     14  2.9|
      Pars Distalis, Hyperplasia, Focal    |                            2                                             |      9  2.3|
      Pars Intermedia, Cyst                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                            3                                             |      2  3.0|
      C-Cell, Hyperplasia                  |                                                                          |      8  1.1|
      Follicle, Cyst                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  13                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 7| 8| 8| 8| 8| 8| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8|                                            |            |
                                           | 8| 8| 5| 3| 6| 8| 8| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      2  3.0|
      Cyst, Multiple                       |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      3  2.7|
      Inflammation, Chronic                |             2                                                            |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                3                                                         |     17  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |    3           3                                                         |      3  2.7|
      Hyperplasia, Cystic                  |       1              2                                                   |      4  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                   M        M                                             |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Depletion Cellular                   |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +        +        +                                                |  20        |
      Mediastinal, Ectasia                 |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      3  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |       3        3        3                                                |     14  3.0|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |                                                                          |      2  2.0|
      Hemorrhage                           |                1                                                         |      3  1.3|
      Hyperplasia, Lymphoid                |       3     2        3                                                   |     13  2.3|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Pigmentation                         |       2              2                                                   |     20  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ectasia                              |                3                                                         |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                            3                                             |      3  2.7|
      Hematopoietic Cell Proliferation     | 2        3                                                               |     15  2.1|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  14                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 7| 8| 8| 8| 8| 8| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8|                                            |            |
                                           | 8| 8| 5| 3| 6| 8| 8| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            | 2     2              3                                                   |     24  2.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  4.0|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +                                             |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |    2  3  1     2  3  2  3  2                                             |     37  2.1|
      Galactocele                          |             3                                                            |      5  3.4|
      Hyperplasia                          |                                                                          |     12  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Osteopetrosis               |       2                                                                  |      8  2.8|
      Femur, Osteopetrosis                 | 4        3                                                               |      9  2.9|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |       3           3  3                                                   |     19  3.3|
      Hydrocephalus                        |       3                                                                  |      4  2.3|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |       +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |       +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  3.5|
      Infiltration Cellular, Histiocyte    |    1  1     1        3  1                                                |     28  1.3|
      Inflammation, Subacute               |                                                                          |      3  3.3|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      3     |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  15                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 7| 8| 8| 8| 8| 8| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8|                                            |            |
                                           | 8| 8| 5| 3| 6| 8| 8| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                         2                                                |      5  2.4|
      Goblet Cell, Hyperplasia             |                1                                                         |     10  1.1|
      Mucosa, Hyperplasia                  |                         2                                                |      5  2.2|
      Mucosa, Metaplasia, Squamous         |                         2                                                |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Cataract                             |                                                                          |      3  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      4  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Mineralization                       | 3  3  3  3  3     2  2  2  2                                             |     57  2.4|
      Nephropathy                          | 1  3  2     2  1  2  1  1                                                |     37  1.7|
      Renal Tubule, Atrophy                |                   3                                                      |      1  3.0|
      Renal Tubule, Cytoplasmic Alteration |                3                                                         |      5  2.6|
      Renal Tubule, Necrosis               |                                                                          |      2  3.0|
      Renal Tubule, Pigmentation           |       1                                                                  |     15  2.3|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  16                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 8| 4| 7| 8| 7| 8| 8| 7| 6| 7| 7| 4| 8| 6| 8| 5| 7| 5| 6| 8| 8| 8| 8| 6|             
                             DAY ON TEST   | 8| 9| 8| 2| 4| 9| 9| 0| 8| 5| 6| 3| 9| 9| 2| 6| 8| 9| 3| 6| 3| 7| 3| 9| 6|             
                                           | 1| 8| 0| 2| 5| 9| 8| 6| 1| 6| 1| 3| 8| 8| 5| 3| 3| 5| 7| 8| 1| 3| 4| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                               X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                2         |             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   2      |             
      Epithelium, Hyperplasia              |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3                                                               |             
      Basophilic Focus                     |    2     2  3  3  4           3  3  1  3              2  2           2   |             
      Eosinophilic Focus                   |             3  4                    3     2        4              3      |             
      Hepatodiaphragmatic Nodule           |       X                             X           X        X     X         |             
      Inflammation, Granulomatous          |          1                                         2  1              3   |             
      Mixed Cell Focus                     |             3                                                        3   |             
      Necrosis, Focal                      | 1                                            1           3               |             
      Bile Duct, Hyperplasia               | 2  2        1           2                                         2  2  1|             
      Hepatocyte, Vacuolization Cytoplasmic|                      3     3                    4           4  3         |             
      Kupffer Cell, Pigmentation           |                                  2           3  3           3        2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +     +                 +           +           +     +   |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |                3     3                 3           3           2     4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3        2     1                          3                    1  1   |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                              3                 2         |             
      Ulcer                                |                                              3                           |             
      Mucosa, Hyperplasia                  |                      3                       3                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                 2                        |             
      Ulcer                                |                                              2                 2         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  17                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 8| 4| 7| 8| 7| 8| 8| 7| 6| 7| 7| 4| 8| 6| 8| 5| 7| 5| 6| 8| 8| 8| 8| 6|             
                             DAY ON TEST   | 8| 9| 8| 2| 4| 9| 9| 0| 8| 5| 6| 3| 9| 9| 2| 6| 8| 9| 3| 6| 3| 7| 3| 9| 6|             
                                           | 1| 8| 0| 2| 5| 9| 8| 6| 1| 6| 1| 3| 8| 8| 5| 3| 3| 5| 7| 8| 1| 3| 4| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    3           2  3     1        2     2  1  3     2     2     2  2  2   |             
      Thrombosis                           |                                              4  3                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    3                          2                    2                 2  3|             
      Degeneration, Fatty                  |                   2  3  1     2  2     4                       3  2      |             
      Hyperplasia, Diffuse                 |                      3                                                   |             
      Hyperplasia, Focal                   |                   3                                                      |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis                             |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2  1                                            1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         4                    3                           |             
      Pars Distalis, Cyst                  |                3     3     3        3        3     3     3  3            |             
      Pars Distalis, Hyperplasia, Focal    |                2     3                       3           1  3           3|             
      Pars Intermedia, Angiectasis         |                                                    3                     |             
      Pars Intermedia, Cyst                |                3                             3                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2              2                                1                 1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   3                                                      |             
      Hyperplasia                          |                                           2     2                 2      |             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Suppurative            |                      2                                            3      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   3     3           3                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           | 2                                            2                    3      |             
      Hyperplasia, Cystic                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |             M                                M  M     M     M     M      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 8| 4| 7| 8| 7| 8| 8| 7| 6| 7| 7| 4| 8| 6| 8| 5| 7| 5| 6| 8| 8| 8| 8| 6|             
                             DAY ON TEST   | 8| 9| 8| 2| 4| 9| 9| 0| 8| 5| 6| 3| 9| 9| 2| 6| 8| 9| 3| 6| 3| 7| 3| 9| 6|             
                                           | 1| 8| 0| 2| 5| 9| 8| 6| 1| 6| 1| 3| 8| 8| 5| 3| 3| 5| 7| 8| 1| 3| 4| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myelofibrosis                        |                                                 3           3  3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +                 +  +                    +  +        +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |    3                 2                       3              2  2  3      |             
      Pancreatic, Pigmentation             |                                                 3                    3   |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                       2                  |             
      Hyperplasia, Lymphoid                |          2  2                 2        2  2                              |             
      Pigmentation                         |    2     2  2     2                       2  2  2                    2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            3                 2              3            |             
      Hematopoietic Cell Proliferation     |                   2           2  3  1              1  2                  |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |       3  3  3     2           2        3  3  2  2  2  2     3        2  3|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       1  2     2  3     2  3  1  2     3     2  2  2  3  2  2  3        2|             
      Galactocele                          |                      4                    4  4                       4   |             
      Hyperplasia                          |    2        2                                                     3      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                                                   3      |             
      Femur, Osteopetrosis                 |                                              3  3                 3      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2     4  4     3     2     1  3     3  4           3              3   |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 8| 4| 7| 8| 7| 8| 8| 7| 6| 7| 7| 4| 8| 6| 8| 5| 7| 5| 6| 8| 8| 8| 8| 6|             
                             DAY ON TEST   | 8| 9| 8| 2| 4| 9| 9| 0| 8| 5| 6| 3| 9| 9| 2| 6| 8| 9| 3| 6| 3| 7| 3| 9| 6|             
                                           | 1| 8| 0| 2| 5| 9| 8| 6| 1| 6| 1| 3| 8| 8| 5| 3| 3| 5| 7| 8| 1| 3| 4| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                          2               |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  1     1                    1     1              1     2     1  2      |             
      Alveolar Epithelium, Hyperplasia     |    2                 3                                                  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1                                                                     |             
      Goblet Cell, Hyperplasia             |    2                                                                     |             
      Mucosa, Hyperplasia                  |                                                       2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |    3  3  2  2  2  2  3  3  3  2  1  3  3  2  1  3  3  2  3  3  2  2  2  3|             
      Nephropathy                          |    2     1  3     3  3  1        1     3  2  2     1        1  2  1  3   |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           | 3  2        3                                               2            |             
      Transitional Epithelium, Hyperplasia |                                                                         1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 7| 8| 7| 5| 6| 7| 8| 8| 7| 7| 8| 8| 6|             
                             DAY ON TEST   | 7| 7| 4| 6| 3| 9| 9| 9| 6| 9| 9| 0| 9| 5| 3| 3| 9| 3| 9| 9| 4| 8| 9| 0| 2|             
                                           | 6| 4| 9| 9| 8| 8| 8| 8| 2| 8| 8| 6| 2| 9| 5| 7| 7| 6| 0| 8| 9| 9| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                   3      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X        X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             2                                                            |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                                                        |             
      Basophilic Focus                     | 2  3     2     3  3  3  3  3  3     2  4     1           3               |             
      Eosinophilic Focus                   | 3  3           3  3                    4                                 |             
      Hepatodiaphragmatic Nodule           |          X                                X                              |             
      Inflammation, Granulomatous          |                            2  2                          2               |             
      Mixed Cell Focus                     |                            2                                             |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1     1              1        1                 2     2     2  2     1   |             
      Hepatocyte, Vacuolization Cytoplasmic|       3                          4                 4  3        3  3  1   |             
      Kupffer Cell, Pigmentation           |       2              2           2                    2        2  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                            +  +  +              +|             
      Accessory Spleen                     |       X                                                                  |             
      Fat, Necrosis                        |                                                    2  3  3              3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1     1  2     2     2  1     3  1        3     4        3         |             
      Acinus, Cytoplasmic Alteration       |                                     3                                    |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                       3                 3|             
      Mucosa, Hyperplasia                  |                                  2                 2              3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    2                     |             
      Erosion                              |                                  1                                       |             
      Ulcer                                |                                                                         3|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 7| 8| 7| 5| 6| 7| 8| 8| 7| 7| 8| 8| 6|             
                             DAY ON TEST   | 7| 7| 4| 6| 3| 9| 9| 9| 6| 9| 9| 0| 9| 5| 3| 3| 9| 3| 9| 9| 4| 8| 9| 0| 2|             
                                           | 6| 4| 9| 9| 8| 8| 8| 8| 2| 8| 8| 6| 2| 9| 5| 7| 7| 6| 0| 8| 9| 9| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1           2  2  3  2  2  2  3     1        2              2  1     3   |             
      Thrombosis                           |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      2  1  1  2                          2              1|             
      Degeneration, Fatty                  |                         1              2        3  4     1  1           2|             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                               3                       1                  |             
      Hypertrophy, Focal                   |                                        2        3           1           2|             
      Necrosis                             |                                           3                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                          1        2     3           3  3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | 3  3        3        3  3  3  3  3  3     3           3  3     3     3   |             
      Pars Distalis, Hyperplasia, Focal    | 3     2           3  2     3                       3  3                 3|             
      Pars Intermedia, Angiectasis         |                                                             3            |             
      Pars Intermedia, Cyst                |                            3                    3                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2  1  2                                   1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             3                 3                       3  3           3   |             
      Hyperplasia                          |             2                                                            |             
      Inflammation, Chronic                |                               2                                          |             
      Inflammation, Suppurative            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3        3  3                    3           3                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                2                 2                                       |             
      Hyperplasia, Cystic                  |                         2  2                          3              2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                            M     M           M     M  M        M  M     M|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  22                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 7| 8| 7| 5| 6| 7| 8| 8| 7| 7| 8| 8| 6|             
                             DAY ON TEST   | 7| 7| 4| 6| 3| 9| 9| 9| 6| 9| 9| 0| 9| 5| 3| 3| 9| 3| 9| 9| 4| 8| 9| 0| 2|             
                                           | 6| 4| 9| 9| 8| 8| 8| 8| 2| 8| 8| 6| 2| 9| 5| 7| 7| 6| 0| 8| 9| 9| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myelofibrosis                        |                                                                   4      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +        +                             +           +  +     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mediastinal, Hemorrhage              |          2                                                               |             
      Mediastinal, Pigmentation            |          3                                                     4         |             
      Pancreatic, Pigmentation             |       2     3                                                            |             
      Renal, Pigmentation                  |             3        3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                2         |             
      Hemorrhage                           | 1                                                                        |             
      Hyperplasia, Lymphoid                |                2        2                    3                           |             
      Pigmentation                         | 2  2                 2        2              2              2  2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                      3   |             
      Hemorrhage                           |                                              3                           |             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      3   |             
      Hematopoietic Cell Proliferation     | 2  2     3     1                    1                                    |             
      Necrosis                             |                                                             4            |             
      Pigmentation, Hemosiderin            |    2     3     2  3        2        2  2     3           3               |             
      Lymphoid Follicle, Atrophy           |                                                                      3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 1  2  3  2     2  2  2  2  2  2     2  2  2     3  2     2  2  1  3  3  2|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |             3                    2                    2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |       3  3           2                 3        2     2  2              3|             
      Femur, Osteopetrosis                 |       3              2                 3              2                 2|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Hemorrhage                           |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                    3        3        2         |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  23                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 7| 8| 7| 5| 6| 7| 8| 8| 7| 7| 8| 8| 6|             
                             DAY ON TEST   | 7| 7| 4| 6| 3| 9| 9| 9| 6| 9| 9| 0| 9| 5| 3| 3| 9| 3| 9| 9| 4| 8| 9| 0| 2|             
                                           | 6| 4| 9| 9| 8| 8| 8| 8| 2| 8| 8| 6| 2| 9| 5| 7| 7| 6| 0| 8| 9| 9| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                       +                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                         2|             
      Infiltration Cellular, Histiocyte    |             1  1  1  1     1     1     2     1  1        1        1  2   |             
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Goblet Cell, Hyperplasia             |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |          2                                                               |             
      Inflammation, Chronic                |                         2                                                |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 3  3  2  2  3  3  3  1  2  2  2  3  3  1  2  3  3  3  3  3  2  2  3  2  3|             
      Nephropathy                          |    1  1  1     2  2     3  1  2     1  1  2  1     1  2  2     1  2     1|             
      Renal Tubule, Atrophy                |                               2     2                                    |             
      Renal Tubule, Cytoplasmic Alteration |                                  2              2              3         |             
      Renal Tubule, Necrosis               |                                  3                                       |             
      Renal Tubule, Pigmentation           |       2     3                                   1     2  2     1  3      |             
      Transitional Epithelium, Hyperplasia |                                     2                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  24                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 7| 6| 8| 8| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8|                                            |            |
                                           | 5| 0| 8| 5| 0| 1| 4| 9| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.125%                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      2  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  3.0|
      Basophilic Focus                     | 2  2  2     3  3        1                                                |     31  2.5|
      Eosinophilic Focus                   |       3                 3                                                |     13  3.2|
      Hepatodiaphragmatic Nodule           |    X  X                 X                                                |     10     |
      Inflammation, Granulomatous          |    1                    1                                                |      9  1.7|
      Mixed Cell Focus                     |    3  3                 3                                                |      6  2.8|
      Necrosis, Focal                      |                                                                          |      3  1.7|
      Bile Duct, Hyperplasia               | 3     2        2           1                                             |     20  1.7|
      Hepatocyte, Vacuolization Cytoplasmic|                   3        3                                             |     14  3.1|
      Kupffer Cell, Pigmentation           | 2        3     2                                                         |     14  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +        +                                                |  13        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |                3        3                                                |     12  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |             1     1  1     2                                             |     21  1.9|
      Acinus, Cytoplasmic Alteration       |                                                                          |      1  3.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                   2                                                      |      3  2.3|
      Ulcer                                |                   3                                                      |      4  3.0|
      Mucosa, Hyperplasia                  |          1     2  2  1                                                   |      9  2.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  25                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 7| 6| 8| 8| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8|                                            |            |
                                           | 5| 0| 8| 5| 0| 1| 4| 9| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.125%                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                                                                          |      2  1.5|
      Ulcer                                |                            2                                             |      4  2.3|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |    2  2  1  1     2     1                                                |     32  1.9|
      Thrombosis                           |                                                                          |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    | 2           2           2                                                |     14  1.9|
      Degeneration, Fatty                  |                            2                                             |     16  2.2|
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |    2           1           2                                             |      6  2.0|
      Hypertrophy, Focal                   |          2        3                                                      |      6  2.2|
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |    1                       1                                             |     11  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |          3                                                               |      3  3.3|
      Pars Distalis, Cyst                  |             3        3                                                   |     24  3.0|
      Pars Distalis, Hyperplasia, Focal    |                   2                                                      |     15  2.6|
      Pars Intermedia, Angiectasis         |                                                                          |      2  3.0|
      Pars Intermedia, Cyst                |             3                                                            |      5  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |    3                                                                     |      9  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                   3                                                      |      7  3.0|
      Hyperplasia                          |       2     3                                                            |      6  2.2|
      Inflammation, Chronic                |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  26                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 7| 6| 8| 8| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8|                                            |            |
                                           | 5| 0| 8| 5| 0| 1| 4| 9| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.125%                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 | 3              3  3                                                      |     11  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                                                                          |      5  2.2|
      Hyperplasia, Cystic                  |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                   +        M                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myelofibrosis                        |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +     +  +     +                                             |  24        |
      Hyperplasia, Lymphoid                |             3                                                            |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |                   3                                                      |      9  2.8|
      Pancreatic, Pigmentation             |          3                 3                                             |      6  2.8|
      Renal, Pigmentation                  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                2                                                         |      2  2.0|
      Hemorrhage                           |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |                         2                                                |      9  2.1|
      Pigmentation                         |    2                    2  2                                             |     19  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                            3                                             |      2  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             | 3                                                                        |      5  2.8|
      Hematopoietic Cell Proliferation     |             3                                                            |     12  1.9|
      Necrosis                             |                      3                                                   |      2  3.5|
      Pigmentation, Hemosiderin            |    3     2     3        3                                                |     27  2.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           | 2  2  2  2  2  2  2  1  3  1                                             |     48  2.1|
      Galactocele                          |                                                                          |      4  4.0|
      Hyperplasia                          |                                                                          |      6  2.3|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  27                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 7| 6| 8| 8| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8|                                            |            |
                                           | 5| 0| 8| 5| 0| 1| 4| 9| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.125%                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cranium, Osteopetrosis               |                                                                          |      9  2.6|
      Femur, Osteopetrosis                 | 3        2                                                               |     10  2.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    3  3        3        4  3                                             |     20  3.0|
      Hydrocephalus                        |                         2                                                |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2                       1                                                |     23  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Goblet Cell, Hyperplasia             |                            1                                             |      2  1.5|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   1        |
      Cataract                             |                4                                                         |      1  4.0|
      Retina, Degeneration                 |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                      4                                                   |      1  4.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  28                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 22:28:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 7| 6| 8| 8| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8|                                            |            |
                                           | 5| 0| 8| 5| 0| 1| 4| 9| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.125%                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |       1                                                                  |      1  1.0|
      Mineralization                       | 2  2        2  2     2  2  2                                             |     56  2.4|
      Nephropathy                          |    2  3        1  2     3                                                |     38  1.8|
      Renal Tubule, Atrophy                |       2                    1                                             |      4  1.8|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      3  2.3|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |       2  3        3     1  2                                             |     16  2.2|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M :