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https://ntp.niehs.nih.gov/go/5098

TDMS Study 05704-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             RESORCINOL


NTP Experiment-Test: 05704-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 17:58:54




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108-46-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          17           15           16                                                  
    Dead                                               5           10           21                                                  
    Accident                                                                     4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           25            9                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
      Inflammation, Chronic, Granulomatous                                       1 (2%)                                             
      Perforation                                                                1 (2%)                                             
   Intestine Large, Cecum                             (47)         (46)         (44)                                                
      Parasite Metazoan                                1 (2%)                    1 (2%)                                             
   Intestine Large, Colon                             (47)         (47)         (46)                                                
      Parasite Metazoan                                7 (15%)      5 (11%)      6 (13%)                                            
   Intestine Large, Rectum                            (47)         (49)         (47)                                                
      Parasite Metazoan                                9 (19%)      4 (8%)       5 (11%)                                            
   Intestine Small, Duodenum                          (47)         (47)         (44)                                                
      Ectopic Tissue                                                             1 (2%)                                             
      Erosion, Multifocal                              1 (2%)                                                                       
      Hyperplasia, Diffuse, Glandular                  2 (4%)                                                                       
      Inflammation, Chronic Active, Diffuse                                      1 (2%)                                             
   Intestine Small, Ileum                             (46)         (47)         (43)                                                
      Inflammation, Chronic Active, Diffuse                                      1 (2%)                                             
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (47)         (44)                                                
      Hyperplasia, Diffuse                             1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Chronic Active, Diffuse                                      1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Focal                               3 (6%)       4 (8%)       1 (2%)                                             
      Basophilic Focus                                 7 (14%)      8 (16%)      3 (6%)                                             
      Basophilic Focus, Multiple                      14 (28%)     13 (26%)      6 (12%)                                            
      Clear Cell Focus                                 5 (10%)     10 (20%)                                                         
      Clear Cell Focus, Multiple                       8 (16%)     10 (20%)      3 (6%)                                             
      Congestion                                                    1 (2%)       2 (4%)                                             
      Cytoplasmic Alteration, Focal                    1 (2%)                    1 (2%)                                             
      Cytoplasmic Alteration, Multifocal                            1 (2%)                                                          
      Degeneration, Cystic, Focal                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Degeneration, Cystic, Multifocal                              1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)                    1 (2%)                                             
      Fatty Change, Focal                              1 (2%)       1 (2%)                                                          
      Granuloma                                                     1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                                                                       
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       4 (8%)       3 (6%)       3 (6%)                                             
      Hyperplasia, Focal                               1 (2%)       3 (6%)                                                          
      Inflammation, Chronic, Multifocal                4 (8%)       6 (12%)      5 (10%)                                            
      Inflammation, Multifocal, Subacute                                         1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis, Focal                                               1 (2%)       2 (4%)                                             
      Necrosis, Multifocal                                                       3 (6%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                                                       
      Bile Duct, Hyperplasia                          45 (90%)     46 (92%)     42 (84%)                                            
      Centrilobular, Fatty Change                     14 (28%)      1 (2%)       1 (2%)                                             
      Centrilobular, Necrosis                          3 (6%)       2 (4%)                                                          
      Periportal, Fatty Change                                      1 (2%)                                                          
   Mesentery                                          (3)          (5)          (1)                                                 
      Fat, Necrosis                                    1 (33%)      3 (60%)      1 (100%)                                           
   Pancreas                                           (49)         (50)         (50)                                                
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Atrophy, Focal                                  15 (31%)     11 (22%)      9 (18%)                                            
      Atrophy, Multifocal                             20 (41%)     16 (32%)      9 (18%)                                            
      Cyst                                                          1 (2%)                                                          
      Hyperplasia, Focal                                            2 (4%)                                                          
      Inflammation, Chronic, Diffuse                                             1 (2%)                                             
      Artery, Inflammation, Chronic                    2 (4%)                    2 (4%)                                             
      Duct, Ectasia, Focal                             1 (2%)                                                                       
      Interlobular, Edema, Diffuse                     1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
      Atrophy, Focal                                                1 (2%)                                                          
      Hyperplasia, Focal                                            1 (2%)       1 (2%)                                             
      Hyperplasia, Multifocal                          1 (2%)                                                                       
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                                                   1 (2%)                                             
   Stomach, Forestomach                               (49)         (50)         (50)                                                
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Erosion, Focal                                                2 (4%)                                                          
      Erosion, Multifocal                              1 (2%)                                                                       
      Hyperplasia, Diffuse, Squamous                   2 (4%)                                                                       
      Hyperplasia, Focal, Squamous                     2 (4%)       1 (2%)       2 (4%)                                             
      Inflammation, Acute                                           3 (6%)       1 (2%)                                             
      Inflammation, Chronic                            5 (10%)      2 (4%)       1 (2%)                                             
      Ulcer, Focal                                     2 (4%)       1 (2%)                                                          
      Ulcer, Multifocal                                2 (4%)       1 (2%)                                                          
   Stomach, Glandular                                 (49)         (50)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ectopic Tissue                                                1 (2%)                                                          
      Erosion, Focal                                   4 (8%)                    2 (4%)                                             
      Erosion, Multifocal                              1 (2%)       2 (4%)                                                          
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hyperplasia, Focal, Glandular                    2 (4%)                                                                       
      Hyperplasia, Focal, Lymphoid                                  1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)                                             
      Mineralization, Diffuse                          1 (2%)                    1 (2%)                                             
      Ulcer, Focal                                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Aorta, Mineralization                                                      1 (100%)                                           
   Heart                                              (50)         (50)         (50)                                                
      Inflammation, Chronic, Focal                     6 (12%)      5 (10%)      6 (12%)                                            
      Inflammation, Chronic, Multifocal               14 (28%)     19 (38%)     10 (20%)                                            
      Mineralization, Multifocal                       1 (2%)                                                                       
      Atrium, Thrombosis                               3 (6%)       1 (2%)       1 (2%)                                             
      Epicardium, Inflammation, Chronic, Diffuse       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (49)                                                
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Congestion                                       2 (4%)       1 (2%)                                                          
      Cytoplasmic Alteration, Focal                    3 (6%)       4 (8%)       1 (2%)                                             
      Cytoplasmic Alteration, Multifocal               1 (2%)                                                                       
      Degeneration, Fatty, Focal                      10 (20%)      6 (12%)      5 (10%)                                            
      Degeneration, Fatty, Multifocal                  3 (6%)       2 (4%)       2 (4%)                                             
      Granuloma                                                     1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)       4 (8%)       1 (2%)                                             
      Hyperplasia, Focal                              10 (20%)      7 (14%)      2 (4%)                                             
      Hyperplasia, Multifocal                          2 (4%)                    3 (6%)                                             
      Hypertrophy, Focal                               1 (2%)                    2 (4%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (49)                                                
      Atypia Nuclear                                                1 (2%)                                                          
      Hyperplasia, Focal                               7 (14%)      7 (14%)      6 (12%)                                            
      Hyperplasia, Multifocal                          2 (4%)                                                                       
   Islets, Pancreatic                                 (49)         (49)         (50)                                                
      Angiectasis, Focal                               1 (2%)                                                                       
      Hyperplasia, Focal                               3 (6%)       2 (4%)       2 (4%)                                             
   Parathyroid Gland                                  (41)         (42)         (44)                                                
      Hyperplasia, Diffuse                             2 (5%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (49)                                                
      Angiectasis, Focal                                            1 (2%)                                                          
      Pars Distalis, Angiectasis, Focal                1 (2%)                                                                       
      Pars Distalis, Congestion                        1 (2%)                                                                       
      Pars Distalis, Cyst                              5 (10%)      3 (6%)                                                          
      Pars Distalis, Hyperplasia, Focal                8 (16%)      5 (10%)      3 (6%)                                             
      Pars Distalis, Hyperplasia, Multifocal           2 (4%)       1 (2%)       2 (4%)                                             
      Pars Distalis, Infiltration Cellular, Focal,                                                                                  
           Histiocyte                                               1 (2%)                                                          
      Pars Intermedia, Cyst                                         2 (4%)                                                          
   Thyroid Gland                                      (49)         (49)         (49)                                                
      Congestion                                                                 1 (2%)                                             
      C-Cell, Hyperplasia, Focal                       9 (18%)      3 (6%)       2 (4%)                                             
      C-Cell, Hyperplasia, Multifocal                  4 (8%)       2 (4%)       1 (2%)                                             
      Follicular Cell, Depletion Secretory             1 (2%)                    2 (4%)                                             
      Follicular Cell, Hyperplasia, Cystic, Focal                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Granuloma Sperm, Focal                                        1 (2%)                                                          
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Penis                                              (1)                                                                           
      Concretion                                       1 (100%)                                                                     
   Preputial Gland                                    (50)         (49)         (50)                                                
      Abscess                                          1 (2%)                    1 (2%)                                             
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             3 (6%)                                                                       
      Dilatation                                                    1 (2%)       1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Multifocal                          2 (4%)                                                                       
      Inflammation, Chronic, Focal                     2 (4%)       6 (12%)      8 (16%)                                            
      Inflammation, Chronic, Multifocal               32 (64%)     29 (59%)     18 (36%)                                            
   Prostate                                           (50)         (50)         (49)                                                
      Hyperplasia, Focal                               4 (8%)       9 (18%)      1 (2%)                                             
      Hyperplasia, Multifocal                          1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Focal                       1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic, Focal                     8 (16%)      7 (14%)      8 (16%)                                            
   Seminal Vesicle                                    (1)          (1)                                                              
      Depletion Secretory                                           1 (100%)                                                        
   Testes                                             (50)         (50)         (50)                                                
      Mineralization, Multifocal                       2 (4%)                                                                       
      Interstitial Cell, Hyperplasia, Multifocal      30 (60%)     17 (34%)     22 (44%)                                            
      Seminiferous Tubule, Degeneration               26 (52%)     12 (24%)      9 (18%)                                            
      Serosa, Necrosis, Focal                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)                                                
      Crystals, Multifocal                             1 (2%)                                                                       
      Mineralization, Multifocal                       1 (2%)                                                                       
      Myelofibrosis, Focal                                          1 (2%)       1 (2%)                                             
      Erythroid Cell, Proliferation                    8 (16%)      7 (14%)      4 (8%)                                             
      Myeloid Cell, Proliferation                                   2 (4%)       2 (4%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                    1 (2%)                                             
      Ectasia                                                                    1 (2%)                                             
      Axillary, Hyperplasia, Lymphoid                                            1 (2%)                                             
      Axillary, Infiltration Cellular, Plasma Cell                               1 (2%)                                             
      Inguinal, Hyperplasia, Plasma Cell               1 (2%)       2 (4%)                                                          
      Mediastinal, Hyperplasia, Plasma Cell            1 (2%)                                                                       
      Mediastinal, Inflammation, Suppurative           1 (2%)                                                                       
      Mediastinal, Pigmentation                        1 (2%)                                                                       
      Pancreatic, Angiectasis                          1 (2%)                                                                       
      Popliteal, Hyperplasia, Lymphoid                              1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (50)         (49)                                                
      Congestion                                       1 (2%)                                                                       
      Cyst, Multiple                                                1 (2%)                                                          
      Erythrophagocytosis                                           1 (2%)                                                          
      Hemorrhage                                       2 (4%)                                                                       
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Sinus, Ectasia                                                2 (4%)                                                          
   Spleen                                             (50)         (50)         (49)                                                
      Congestion                                                    1 (2%)                                                          
      Developmental Malformation                       1 (2%)                                                                       
      Fibrosis, Diffuse                                             1 (2%)                                                          
      Fibrosis, Focal                                  4 (8%)       3 (6%)       1 (2%)                                             
      Fibrosis, Multifocal                             1 (2%)       1 (2%)                                                          
      Hematocyst                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                 8 (16%)      4 (8%)       6 (12%)                                            
      Metaplasia, Focal, Osseous                                    1 (2%)                                                          
      Pigmentation, Diffuse, Hemosiderin               1 (2%)       2 (4%)                                                          
   Thymus                                             (46)         (46)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Cyst                                             2 (4%)       1 (2%)                                                          
      Hemorrhage                                       4 (9%)       4 (9%)      15 (31%)                                            
      Hemorrhage, Multifocal                                                     2 (4%)                                             
      Epithelial Cell, Hyperplasia, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (49)                                                
      Galactocele                                      5 (10%)      3 (6%)                                                          
      Mineralization, Multifocal                       1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Subcutaneous Tissue, Abscess                                               1 (2%)                                             
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Fibrous Osteodystrophy                           2 (4%)                    2 (4%)                                             
      Cranium, Hyperostosis                            1 (2%)                                                                       
      Trabecula, Hyperostosis, Multifocal              1 (2%)                                                                       
   Skeletal Muscle                                    (3)                       (1)                                                 
      Abdominal, Necrosis, Focal                       1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Mineralization, Multifocal                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       5 (10%)      6 (12%)     11 (22%)                                            
      Edema, Focal                                     1 (2%)                    1 (2%)                                             
      Emphysema                                                     1 (2%)       1 (2%)                                             
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage, Focal                                             2 (4%)       2 (4%)                                             
      Infiltration Cellular, Diffuse, Histiocyte                                 1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Infiltration Cellular, Multifocal, Histiocyte                              1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Multifocal, Suppurative                                      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mineralization, Multifocal                       1 (2%)                                                                       
      Necrosis, Acute                                                            1 (2%)                                             
      Pigmentation, Multifocal                                                   1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       1 (2%)                                                          
      Alveolus, Infiltration Cellular, Multifocal,                                                                                  
           Histiocyte                                               1 (2%)                                                          
      Alveolus, Inflammation, Chronic, Focal                        2 (4%)       1 (2%)                                             
      Alveolus, Inflammation, Chronic, Multifocal                   1 (2%)                                                          
      Interstitium, Inflammation, Chronic, Diffuse                  1 (2%)                                                          
      Interstitium, Inflammation, Chronic, Focal       2 (4%)                    1 (2%)                                             
      Perivascular, Edema, Multifocal                                            1 (2%)                                             
   Nose                                               (49)         (49)         (50)                                                
      Congestion                                                                 2 (4%)                                             
      Foreign Body                                     4 (8%)       2 (4%)       4 (8%)                                             
      Fungus                                           4 (8%)                    2 (4%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            4 (8%)       1 (2%)       5 (10%)                                            
      Inflammation, Suppurative                        2 (4%)       2 (4%)       7 (14%)                                            
      Metaplasia, Squamous                                          1 (2%)                                                          
      Mucosa, Thrombosis, Multifocal                   2 (4%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)       3 (6%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)       1 (2%)       2 (4%)                                             
      Olfactory Epithelium, Metaplasia                 1 (2%)                                                                       
   Trachea                                            (50)         (50)         (49)                                                
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Epithelium, Metaplasia                           1 (2%)                                                                       
      Glands, Ectasia, Focal                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)          (4)          (6)                                                 
      Ectopic Tissue, Multifocal                       1 (17%)                                                                      
      Anterior Chamber, Hemorrhage                                  1 (25%)                                                         
      Anterior Chamber, Iris, Posterior Chamber,                                                                                    
           Inflammation                                             1 (25%)                                                         
      Cornea, Inflammation                                          1 (25%)                                                         
      Lens, Cataract                                   1 (17%)      3 (75%)                                                         
      Retina, Degeneration                             1 (17%)      2 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                    2 (4%)                                             
      Cyst                                                          4 (8%)       3 (6%)                                             
      Hydronephrosis, Chronic                                                    1 (2%)                                             
      Hyperplasia, Multifocal, Tubular                 2 (4%)       1 (2%)       5 (10%)                                            
      Necrosis, Acute, Focal                           1 (2%)                                                                       
      Nephropathy, Chronic                            48 (96%)     49 (98%)     43 (86%)                                            
      Pigmentation                                                               1 (2%)                                             
      Pigmentation, Diffuse                            1 (2%)       2 (4%)       1 (2%)                                             
      Cortex, Mineralization, Multifocal               2 (4%)                    1 (2%)                                             
      Cortex, Necrosis, Diffuse                                     1 (2%)                                                          
      Papilla, Transitional Epithelium, Hyperplasia    2 (4%)                    2 (4%)                                             
      Pelvis, Inflammation, Chronic                    1 (2%)                                                                       
      Pelvis, Mineralization                           1 (2%)                                                                       
      Pelvis, Parasite Metazoan                                     1 (2%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Degeneration, Hyaline                        2 (4%)                                                                       
   Urinary Bladder                                    (50)         (50)         (49)                                                
      Concretion                                       1 (2%)       1 (2%)       4 (8%)                                             
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic, Diffuse                   2 (4%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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