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TDMS Study 05704-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             RESORCINOL


NTP Experiment-Test: 05704-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 17:58:56




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108-46-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05704-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          17           15           16                                                  
    Dead                                               5           10           21                                                  
    Accident                                                                     4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           25            9                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
   Intestine Large, Cecum                             (47)         (46)         (44)                                                
   Intestine Large, Colon                             (47)         (47)         (46)                                                
      Schwannoma Malignant, Metastatic, Epididymis                  1 (2%)                                                          
   Intestine Large, Rectum                            (47)         (49)         (47)                                                
   Intestine Small, Duodenum                          (47)         (47)         (44)                                                
      Leiomyosarcoma                                                1 (2%)                                                          
   Intestine Small, Ileum                             (46)         (47)         (43)                                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (47)         (44)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Adenoma                           1 (2%)                                                                       
      Histiocytic Sarcoma, Metastatic                  1 (2%)                                                                       
      Neoplastic Nodule                                1 (2%)                                                                       
   Mesentery                                          (3)          (5)          (1)                                                 
      Lipoma                                                        1 (20%)                                                         
      Schwannoma Malignant, Metastatic, Epididymis                  1 (20%)                                                         
   Pancreas                                           (49)         (50)         (50)                                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Epididymis                  1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)                                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Schwannoma Malignant                             1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (50)         (50)                                                
   Stomach, Glandular                                 (49)         (50)         (49)                                                
      Schwannoma Malignant, Metastatic, Epididymis                  1 (2%)                                                          
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Tooth                                              (1)          (1)                                                              
                                                             Page   2                                                               
NTP Experiment-Test: 05704-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (49)                                                
      Adenoma                                          1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Epididymis                  1 (2%)                                                          
   Adrenal Gland, Medulla                             (49)         (50)         (49)                                                
      Pheochromocytoma Malignant                       5 (10%)      2 (4%)                                                          
      Pheochromocytoma Benign                          9 (18%)      8 (16%)      5 (10%)                                            
      Pheochromocytoma Benign, Multiple                             1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (49)         (50)                                                
      Adenoma                                          2 (4%)       2 (4%)                                                          
   Pituitary Gland                                    (50)         (50)         (49)                                                
      Pars Distalis, Adenoma                          14 (28%)      9 (18%)      3 (6%)                                             
   Thyroid Gland                                      (49)         (49)         (49)                                                
      C-Cell, Adenoma                                  3 (6%)       4 (8%)       5 (10%)                                            
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Schwannoma Malignant                                          1 (2%)                                                          
   Preputial Gland                                    (50)         (49)         (50)                                                
      Adenocarcinoma                                                1 (2%)                                                          
      Adenoma                                          8 (16%)      4 (8%)       2 (4%)                                             
      Adenoma, Multiple                                             2 (4%)                                                          
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
   Prostate                                           (50)         (50)         (49)                                                
   Testes                                             (50)         (50)         (50)                                                
      Schwannoma Malignant, Metastatic, Epididymis                  1 (2%)                                                          
      Interstitial Cell, Adenoma                       8 (16%)      7 (14%)      3 (6%)                                             
      Interstitial Cell, Adenoma, Multiple            37 (74%)     37 (74%)     28 (56%)                                            
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05704-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)                                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Lymph Node                                         (50)         (50)         (50)                                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (49)                                                
      Schwannoma Malignant, Metastatic, Epididymis                  1 (2%)                                                          
   Spleen                                             (50)         (50)         (49)                                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Thymus                                             (46)         (46)         (48)                                                
      Thymoma Benign                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (49)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Fibroadenoma                                     2 (4%)       1 (2%)                                                          
   Skin                                               (50)         (50)         (50)                                                
      Epidermis, Keratoacanthoma                       1 (2%)       2 (4%)       1 (2%)                                             
      Epidermis, Squamous Cell Papilloma                            2 (4%)                                                          
      Epidermis, Trichoepithelioma                                  1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     3 (6%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (3)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Malignant                                         1 (2%)       1 (2%)                                             
      Glioma NOS                                       1 (2%)                                                                       
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Chordoma, Metastatic, Uncertain Primary Site                               1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
                                                             Page   4                                                               
NTP Experiment-Test: 05704-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Nose                                               (49)         (49)         (50)                                                
   Trachea                                            (50)         (50)         (49)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Pinna, Schwannoma Malignant                                                1 (100%)                                           
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Epididymis                  1 (2%)                                                          
      Cortex, Adenoma                                                            1 (2%)                                             
      Pelvis, Transitional Epithelium, Papilloma                    1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            17 (34%)     25 (50%)      8 (16%)                                            
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
      Mesothelioma Malignant                           4 (8%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05704-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          49          31                                                   
     Total Primary Neoplasms                          124         120          64                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          48          31                                                   
     Total Benign Neoplasms                            90          84          51                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          32          12                                                   
     Total Malignant Neoplasms                         33          36          13                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           1           1                                                   
     Total Metastatic Neoplasm                         15           8           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
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