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TDMS Study 05704-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: IRDC                                                      DATE: 09/18/94   
EXP: 05704                       RESORCINOL                    TIME: 18:06:24   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 05970A   
CONT: 05700-04                                                 CAS: 108-46-3    
PATHOLOGIST: F. VOELKER                      S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: IRDC                                                      DATE: 09/18/94  
EXP: 05704                       RESORCINOL                    TIME: 18:06:24  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 05970A  
CONT: 05700-04                                                 CAS: 108-46-3   
PATHOLOGIST: F. VOELKER                      S. EUSTIS                         

                                    RESORCINOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      287   287   384   478   499   558   563   569   585   610                 |
 |      629   642   644   652   657   657   660   677   692   694                 |
 |      721   728                                                                 |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 112MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 25     CENSORED DEATHS 10   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      279   380   492   492   532   532   562   566   588   596                 |
 |      601   616   624   629   637   639   650   650   666   679                 |
 |      692   708   712   714   719                                               |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 225MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 37     CENSORED DEATHS 14   TERMINAL 9         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      10    44    58    119   182   217   255   262   269   303                 |
 |      303   307   317   317   339   399   400   419   429   492                 |
 |      503   527   537   538   560   574   574   576   586   594                 |
 |      611   625   653   706   721   721   728                                   |
 |  CENSORED DEATHS                                                               |
 |      282   330   412   429   434   436   440   443   454   456                 |
 |      456   456   456   469                                                     |
 |                                                                                |
 ==================================================================================

                                    RESORCINOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  96.7  95.0  93.0  91.0  82.9  66.7  56.6      |
 |           |                                                                    |
 |           |                                                                    |
 |112MG/KG   |   100.0 100.0 100.0  98.3  96.7  96.7  88.6  78.5  64.4  50.3      |
 |           |                                                                    |
 |           |                                                                    |
 |225MG/KG   |    95.0  93.3  85.0  74.8  69.5  67.7  55.2  40.1  32.6  22.6      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          112MG/KG         225MG/KG      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.6%            50.3%            22.6%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P=0.647          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       585.1            598.2            426.4         |
 |NATURAL DEATHS (C)      |       (27.1)           (21.1)           (33.1)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       630.8            629.0            471.5         |
 |(STANDARD ERROR)        |       (16.5)           (15.4)           (24.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                    RESORCINOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 99999 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 225MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 16     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      44    48    50    63    69    72    72    77    77    79                  |
 |      98    119   121   141   147   149                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                    RESORCINOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 99999 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   1E5 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |225MG/KG   |    37.5   6.3   6.3   6.3   6.3   6.3   6.3   6.3   6.3   6.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                                     DOSE       |
 |                                                                                |
 |                                225MG/KG                                        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|        6.3%                                           |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----                                          |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |        89.1                                           |
 |NATURAL DEATHS (C)      |       ( 8.9)                                          |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |        89.1                                           |
 |(STANDARD ERROR)        |       ( 8.9)                                          |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             RESORCINOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        112MG/KG         = 2
                                                        225MG/KG         = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1 3                                         21
      |   3     3 3                                 21               1                2
      |           3        3                                         1              1
      |                    3         3    3                                         1 21    2
   90 +                                   3      3                                     1        11
      |                                          333                                        2    11
      |                                            3    3                                        21 1
      |                                                                                             1  2 1
P  80 +                                                 3  3                                             1 1 1
E     |                                                    3  3                                        2 2 2
R     |                                                       3        3                                     1 1
C     |                                                                33 3                                22
E  70 +                                                                   3 3                               22
N     |                                                                     3         3                      221 1 1
T     |                                                                               33                      2   21 1
      |                                                                                3    3                     22 11
S  60 +                                                                                     33                     2 21  1
U     |                                                                                                              2  211 1
R     |                                                                                      3  3
V     |                                                                                         3 3                     22
I  50 +                                                                                                                  2  2
V     |                                                                                           33
A     |                                                                                            33
L     |                                                                                             3 3
   40 +                                                                                               3  3
      |                                                                                                  3 3
      |                                                                                                    3   3
      |                                                                                                        3       3
   30 +                                                                                                                3 3
      |
      |                                                                                                                  33
      |                                                                                                                   3 3
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.

                                                             RESORCINOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        225MG/KG         = 1

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

           |
           |
       100 +  1                                  1
           |
           |
           |
        90 +
           |                                     1    1
           |
           |                                          1    1
        80 +
           |
           |                                               1    1
           |
     P  70 +                                                    1    1
     E     |
     R     |
     C     |
     E  60 +
     N     |
     T     |
           |
     S  50 +
     U     |
     R     |                                                         1    1
     V     |
     I  40 +
     V     |                                                              1         1
     A     |
     L     |                                                                        1              1
        30 +
           |
           |                                                                                       1    1
           |
        20 +                                                                                            1              1
           |
           |
           |
        10 +
           |                                                                                                           1    1
           |
           |
         0 +
           |
           ---+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+--
              0    1    2    3    4    5    6    7    8    9   10   11   12   13   14   15   16   17   18   19   20   21   22

                                                                   WEEK