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TDMS Study 05704-03 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             RESORCINOL


NTP Experiment-Test: 05704-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 18:48:42




       Facility:  International Research and Development Corp.

       Chemical CAS #:  000108463

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05704-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          15           11           16           12                                     
    Dead                                               1            5            6           13                                     
    Accident                                                        1                                                               
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           33           27           24                                     
    Dead                                                                         1                                                  
  Animals Examined Microscopically                    58           53           55           57                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (48)         (47)         (46)         (48)                                   
      Abscess                                                       1 (2%)                                                          
   Intestine Large, Cecum                             (50)         (50)         (49)         (46)                                   
      Parasite Metazoan                                             1 (2%)                    1 (2%)                                
   Intestine Large, Colon                             (50)         (50)         (50)         (48)                                   
      Parasite Metazoan                                6 (12%)      4 (8%)       4 (8%)       6 (13%)                               
   Intestine Large, Rectum                            (50)         (50)         (50)         (47)                                   
      Parasite Metazoan                                5 (10%)      4 (8%)                    4 (9%)                                
   Intestine Small, Duodenum                          (50)         (50)         (49)         (48)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Small, Ileum                             (50)         (50)         (49)         (47)                                   
      Parasite Metazoan                                1 (2%)                                                                       
   Liver                                              (51)         (50)         (50)         (51)                                   
      Angiectasis, Focal                               3 (6%)       3 (6%)       5 (10%)      1 (2%)                                
      Basophilic Focus                                 9 (18%)     14 (28%)     11 (22%)      7 (14%)                               
      Basophilic Focus, Multiple                      32 (63%)     27 (54%)     19 (38%)     27 (53%)                               
      Clear Cell Focus                                10 (20%)      5 (10%)      1 (2%)       7 (14%)                               
      Clear Cell Focus, Multiple                       2 (4%)       4 (8%)       3 (6%)       1 (2%)                                
      Congestion, Focal                                1 (2%)       3 (6%)                                                          
      Cytoplasmic Alteration, Focal                                 3 (6%)       1 (2%)       1 (2%)                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Granuloma, Focal                                              1 (2%)                    1 (2%)                                
      Hematocyst                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                                        2 (4%)                                
      Hepatodiaphragmatic Nodule                       4 (8%)       9 (18%)      7 (14%)      7 (14%)                               
      Hepatodiaphragmatic Nodule, Multiple             4 (8%)       2 (4%)       1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
      Inflammation, Chronic, Focal                    32 (63%)     25 (50%)     29 (58%)     24 (47%)                               
      Necrosis, Focal                                  1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05704-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Pigmentation                                                               1 (2%)                                             
      Bile Duct, Cyst                                               1 (2%)                    1 (2%)                                
      Bile Duct, Hyperplasia                          32 (63%)     23 (46%)     26 (52%)     35 (69%)                               
      Centrilobular, Atrophy, Diffuse                               1 (2%)                                                          
      Centrilobular, Fatty Change                      7 (14%)      8 (16%)      5 (10%)      1 (2%)                                
      Periportal, Fatty Change                                                   1 (2%)                                             
      Serosa, Fibrosis, Focal                          2 (4%)       1 (2%)                                                          
      Serosa, Inflammation, Chronic, Focal                                       1 (2%)                                             
   Mesentery                                          (2)                       (2)          (3)                                    
      Fat, Necrosis                                    2 (100%)                  2 (100%)     2 (67%)                               
   Pancreas                                           (50)         (49)         (50)         (49)                                   
      Atrophy, Focal                                  17 (34%)     15 (31%)     19 (38%)     13 (27%)                               
      Focal Cellular Change                            1 (2%)       1 (2%)                                                          
      Hyperplasia, Focal                               2 (4%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Metaplasia, Focal                                             1 (2%)                                                          
      Artery, Inflammation, Chronic, Focal                                       1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (48)         (50)                                   
      Atrophy                                                       3 (6%)       2 (4%)                                             
      Cyst                                                                                    1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Duct, Ectasia, Focal                             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (48)         (50)                                   
      Hyperplasia, Diffuse, Squamous                   1 (2%)                    2 (4%)                                             
      Hyperplasia, Focal, Squamous                                  1 (2%)       1 (2%)                                             
      Inflammation, Acute, Diffuse                                                            1 (2%)                                
      Inflammation, Chronic, Diffuse                   1 (2%)                    2 (4%)                                             
      Inflammation, Chronic, Focal                                  3 (6%)       1 (2%)                                             
      Mineralization                                                             1 (2%)       2 (4%)                                
      Ulcer                                            1 (2%)       1 (2%)       2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                          1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Acute, Focal                                                              1 (2%)                                
      Mineralization                                                             1 (2%)       2 (4%)                                
      Ulcer                                                         2 (4%)       1 (2%)                                             
   Tongue                                                          (1)                                                              
      Epithelium, Hyperplasia, Focal                                1 (100%)                                                        
   Tooth                                              (1)          (3)                       (1)                                    
      Inflammation, Chronic                                         2 (67%)                   1 (100%)                              
      Gingiva, Foreign Body                            1 (100%)                                                                     
      Gingiva, Hyperplasia, Focal, Squamous            1 (100%)                                                                     
      Gingiva, Inflammation, Chronic, Focal            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05704-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic, Focal                    28 (56%)     28 (56%)     29 (58%)     22 (44%)                               
      Mineralization, Multifocal                                                 1 (2%)       1 (2%)                                
      Thrombosis                                                    1 (2%)                                                          
      Artery, Hyperplasia, Focal                                                              1 (2%)                                
      Artery, Mineralization                                                                  1 (2%)                                
      Atrium, Thrombosis                                                         1 (2%)                                             
      Endocardium, Hemorrhage, Focal                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      4 (8%)       3 (6%)       2 (4%)                                             
      Atrophy, Diffuse                                                           1 (2%)                                             
      Congestion                                                                 1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                    2 (4%)       1 (2%)       1 (2%)                                             
      Degeneration, Ballooning, Focal                  1 (2%)                                                                       
      Degeneration, Diffuse, Fatty                                                            1 (2%)                                
      Degeneration, Fatty, Focal                      17 (34%)     15 (30%)     22 (44%)     10 (20%)                               
      Hematocyst                                       2 (4%)                                                                       
      Hemorrhage, Focal                                             1 (2%)                                                          
      Hyperplasia, Focal                              14 (28%)     13 (26%)      7 (14%)      7 (14%)                               
      Hypertrophy, Focal                               2 (4%)                    3 (6%)       2 (4%)                                
      Mineralization, Focal                                         1 (2%)                                                          
      Pigmentation                                                               1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (49)         (45)         (48)                                   
      Angiectasis                                                                             1 (2%)                                
      Hematocyst                                                                 1 (2%)                                             
      Hyperplasia                                     14 (29%)     15 (31%)     14 (31%)      8 (17%)                               
   Islets, Pancreatic                                 (50)         (47)         (49)         (49)                                   
      Hyperplasia, Focal                                            2 (4%)                    2 (4%)                                
   Parathyroid Gland                                  (46)         (39)         (42)         (41)                                   
      Hyperplasia, Diffuse                                                       1 (2%)                                             
      Hyperplasia, Focal                                            1 (3%)                                                          
      Hypoplasia, Diffuse                                           1 (3%)                                                          
   Pituitary Gland                                    (53)         (51)         (52)         (52)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                     10 (19%)      6 (12%)      7 (13%)      7 (13%)                               
      Cyst                                            17 (32%)     23 (45%)     21 (40%)     19 (37%)                               
      Cyst, Multiple                                   4 (8%)       3 (6%)       9 (17%)      2 (4%)                                
      Ectasia                                          1 (2%)                                                                       
      Pigmentation, Focal                                           1 (2%)                                                          
      Pars Distalis, Angiectasis                       1 (2%)                                 1 (2%)                                
      Pars Distalis, Angiectasis, Focal                             3 (6%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05704-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia, Focal                8 (15%)      8 (16%)     11 (21%)      5 (10%)                               
      Pars Distalis, Hyperplasia, Multifocal           1 (2%)                                                                       
      Pars Distalis, Hypoplasia                                                  1 (2%)                                             
      Pars Distalis, Metaplasia, Focal, Osseous                     1 (2%)                                                          
      Pars Nervosa, Metaplasia, Focal, Osseous                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Hemorrhage, Multifocal                                        1 (2%)                                                          
      C-Cell, Hyperplasia, Focal                       9 (18%)     12 (24%)     10 (20%)      1 (2%)                                
      Follicular Cell, Metaplasia, Focal, Squamous     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (41)         (42)         (49)                                   
      Atrophy                                                       1 (2%)                    1 (2%)                                
      Concretion                                                                 1 (2%)                                             
      Dilatation                                       2 (4%)                    1 (2%)       3 (6%)                                
      Hyperplasia, Focal                               3 (7%)       3 (7%)       1 (2%)       3 (6%)                                
      Inflammation, Chronic, Focal                     5 (11%)      4 (10%)      1 (2%)       2 (4%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
   Ovary                                              (52)         (50)         (49)         (51)                                   
      Congestion                                                    2 (4%)                                                          
      Cyst                                             7 (13%)      5 (10%)      4 (8%)       2 (4%)                                
      Granuloma, Focal                                              1 (2%)                                                          
      Corpus Luteum, Necrosis                          1 (2%)                                                                       
      Periovarian Tissue, Necrosis, Focal              1 (2%)                                                                       
   Uterus                                             (51)         (52)         (52)         (52)                                   
      Dilatation                                                    2 (4%)       1 (2%)       1 (2%)                                
      Fibrosis                                                      2 (4%)                                                          
      Hydrometra                                                    1 (2%)                    1 (2%)                                
      Hyperplasia, Chronic, Cystic                     4 (8%)                    1 (2%)       2 (4%)                                
      Hyperplasia, Cystic                                                        1 (2%)                                             
      Inflammation, Suppurative                                                               1 (2%)                                
      Artery, Mineralization, Focal                                                           1 (2%)                                
      Cervix, Fibrosis                                 1 (2%)       1 (2%)                    1 (2%)                                
      Lumen, Hemorrhage                                             1 (2%)       1 (2%)                                             
      Serosa, Necrosis                                 1 (2%)                                                                       
   Vagina                                             (2)                       (1)                                                 
      Inflammation, Subacute                                                     1 (100%)                                           
      Necrosis, Acute, Diffuse                                                   1 (100%)                                           
      Prolapse                                                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05704-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (48)                                   
      Myelofibrosis, Focal                             1 (2%)       1 (2%)       3 (6%)                                             
      Erythroid Cell, Proliferation                    1 (2%)                    3 (6%)       1 (2%)                                
      Myeloid Cell, Proliferation                      1 (2%)                    1 (2%)       2 (4%)                                
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Axillary, Hyperplasia, Plasma Cell                                                      1 (2%)                                
      Axillary, Infiltration Cellular, Histiocyte      1 (2%)                    1 (2%)                                             
      Iliac, Ectasia                                                1 (2%)                                                          
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)                                                                       
      Iliac, Infiltration Cellular, Histiocyte                      1 (2%)                                                          
      Inguinal, Ectasia                                                          2 (4%)                                             
      Inguinal, Hyperplasia, Lymphoid                                            1 (2%)                                             
      Inguinal, Hyperplasia, Plasma Cell                                         1 (2%)                                             
      Mandibular, Congestion                           1 (2%)       1 (2%)                    1 (2%)                                
      Mandibular, Hyperplasia, Plasma Cell             2 (4%)       1 (2%)       2 (4%)       2 (4%)                                
      Mediastinal, Congestion                                       2 (4%)                    1 (2%)                                
      Mediastinal, Hemorrhage                          1 (2%)                                 2 (4%)                                
      Mediastinal, Hyperplasia, Lymphoid                            1 (2%)                                                          
      Mediastinal, Hyperplasia, Plasma Cell                         1 (2%)                    1 (2%)                                
      Mediastinal, Inflammation, Suppurative           1 (2%)                                                                       
      Mediastinal, Pigmentation                                                  1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (48)         (50)                                   
      Congestion                                       1 (2%)       1 (2%)                                                          
      Fibrosis, Focal                                               1 (2%)                                                          
      Granuloma, Focal                                                                        1 (2%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
   Spleen                                             (50)         (50)         (51)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion, Focal                                                          1 (2%)       2 (4%)                                
      Fibrosis, Focal                                                            2 (4%)                                             
      Hematocyst                                                                              1 (2%)                                
      Hematopoietic Cell Proliferation                 4 (8%)       2 (4%)       3 (6%)       5 (10%)                               
      Hematopoietic Cell Proliferation Granulocytic                                           1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Necrosis, Acute, Focal                                                                  1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
      Capsule, Fibrosis                                1 (2%)                                 1 (2%)                                
   Thymus                                             (47)         (45)         (48)         (48)                                   
      Cyst                                             1 (2%)       1 (2%)       3 (6%)       2 (4%)                                
      Cyst, Multiple                                                2 (4%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)                    5 (10%)                               
      Epithelial Cell, Hyperplasia                                                            1 (2%)                                
      Mediastinum, Inflammation, Acute                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05704-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (50)         (50)         (50)                                   
      Galactocele                                      1 (2%)       1 (2%)                                                          
      Galactocele, Multiple                                         1 (2%)                                                          
      Hyperplasia, Cystic, Glandular                                             2 (4%)                                             
      Mineralization                                                             1 (2%)                                             
   Skin                                               (50)         (50)         (51)         (50)                                   
      Developmental Malformation                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (49)                                   
      Cranium, Hyperostosis                                         1 (2%)                                                          
      Femur, Fibrous Osteodystrophy                                              1 (2%)       1 (2%)                                
      Femur, Hyperostosis                                           3 (6%)       1 (2%)                                             
      Femur, Osteopetrosis                             1 (2%)       2 (4%)                    2 (4%)                                
      Maxilla, Hyperostosis                                                      1 (2%)                                             
      Turbinate, Hyperostosis                                       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Hemorrhage, Focal                                2 (4%)       3 (6%)                    1 (2%)                                
   Spinal Cord                                                                               (1)                                    
      Hemorrhage, Focal                                                                       1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (51)         (50)                                   
      Congestion                                       7 (14%)     12 (24%)     11 (22%)      8 (16%)                               
      Congestion, Diffuse                                                        1 (2%)                                             
      Emphysema, Focal                                              1 (2%)                    1 (2%)                                
      Foreign Body                                     3 (6%)                    1 (2%)                                             
      Granuloma, Focal                                                           3 (6%)                                             
      Hemorrhage, Focal                                1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Hyperplasia, Focal                               2 (4%)       4 (8%)       5 (10%)      2 (4%)                                
      Inflammation, Acute, Focal                       1 (2%)                                 1 (2%)                                
      Inflammation, Chronic, Diffuse                                             1 (2%)                                             
      Inflammation, Chronic, Focal                     6 (12%)      3 (6%)       1 (2%)       5 (10%)                               
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
      Interstitium, Mineralization, Diffuse                                      1 (2%)                                             
      Interstitium, Mineralization, Focal                                                     1 (2%)                                
   Nose                                               (49)         (50)         (50)         (50)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05704-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Foreign Body                                     1 (2%)       1 (2%)       2 (4%)       4 (8%)                                
      Fungus                                           1 (2%)       2 (4%)       1 (2%)       3 (6%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Acute, Focal                                                 2 (4%)                                             
      Inflammation, Chronic, Focal                     2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Focal, Suppurative                 1 (2%)       2 (4%)                    6 (12%)                               
      Metaplasia, Squamous                                                       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)                    1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Mineralization, Focal                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (7)          (1)          (3)                                    
      Atrophy                                                       2 (29%)                                                         
      Cataract                                         1 (33%)                                                                      
      Synechia                                                      2 (29%)                                                         
      Lens, Cataract                                   1 (33%)      5 (71%)      1 (100%)     2 (67%)                               
      Retina, Degeneration                                          5 (71%)                   1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Congestion                                                    2 (4%)       2 (4%)       3 (6%)                                
      Cyst                                             2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Degeneration, Diffuse, Hyaline                                             1 (2%)                                             
      Glomerulosclerosis                               1 (2%)                                                                       
      Hemorrhage, Focal                                             1 (2%)                                                          
      Hydronephrosis                                                                          1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Mineralization                                                             1 (2%)       2 (4%)                                
      Nephropathy, Chronic                            47 (94%)     47 (94%)     48 (96%)     43 (86%)                               
      Pigmentation                                     4 (8%)       2 (4%)       4 (8%)       3 (6%)                                
      Pelvis, Hemorrhage                               1 (2%)                                                                       
      Pelvis, Hyperplasia                              1 (2%)                                                                       
      Pelvis, Inflammation, Chronic                    2 (4%)                                                                       
      Pelvis, Mineralization                                                     1 (2%)                                             
   Urinary Bladder                                    (50)         (49)         (48)         (49)                                   
      Inflammation, Chronic, Focal                                               1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
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                             ----------              END OF REPORT             ----------                                           
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