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TDMS Study 05704-03 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             RESORCINOL


NTP Experiment-Test: 05704-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 18:48:44




       Facility:  International Research and Development Corp.

       Chemical CAS #:  000108463

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05704-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          15           11           16           12                                     
    Dead                                               1            5            6           13                                     
    Accident                                                        1                                                               
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           33           27           24                                     
    Dead                                                                         1                                                  
  Animals Examined Microscopically                    58           53           55           57                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (48)         (47)         (46)         (48)                                   
      Schwannoma Malignant, Metastatic, Salivary                                                                                    
          Glands                                                                              1 (2%)                                
   Intestine Large, Cecum                             (50)         (50)         (49)         (46)                                   
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Large, Colon                             (50)         (50)         (50)         (48)                                   
   Intestine Large, Rectum                            (50)         (50)         (50)         (47)                                   
   Intestine Small, Duodenum                          (50)         (50)         (49)         (48)                                   
   Intestine Small, Ileum                             (50)         (50)         (49)         (47)                                   
   Intestine Small, Jejunum                           (50)         (50)         (49)         (48)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
   Liver                                              (51)         (50)         (50)         (51)                                   
      Hepatocellular Adenoma                           1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (2)                       (2)          (3)                                    
   Pancreas                                           (50)         (49)         (50)         (49)                                   
   Pharynx                                            (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Salivary Glands                                    (50)         (50)         (48)         (50)                                   
      Schwannoma Malignant                                                                    1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (48)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tooth                                              (1)          (3)                       (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05704-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (48)         (49)         (45)         (48)                                   
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)                    6 (13%)      1 (2%)                                
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (47)         (49)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                                  1 (2%)                                             
   Parathyroid Gland                                  (46)         (39)         (42)         (41)                                   
   Pituitary Gland                                    (53)         (51)         (52)         (52)                                   
      Adenoma                                          1 (2%)                                                                       
      Pars Distalis, Adenoma                          27 (51%)     27 (53%)     21 (40%)     23 (44%)                               
      Pars Distalis, Adenoma, Multiple                                                        1 (2%)                                
      Pars Distalis, Carcinoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Schwannoma Malignant, Metastatic, Salivary                                                                                    
          Glands                                                                              1 (2%)                                
      C-Cell, Adenoma                                  2 (4%)       3 (6%)       4 (8%)       4 (8%)                                
      C-Cell, Carcinoma                                2 (4%)       1 (2%)                    1 (2%)                                
      Follicular Cell, Adenoma                         2 (4%)                    1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                       2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (41)         (42)         (49)                                   
      Adenoma                                          8 (17%)      7 (17%)      6 (14%)      4 (8%)                                
      Adenoma, Multiple                                1 (2%)       1 (2%)                                                          
      Carcinoma                                                                  3 (7%)                                             
   Ovary                                              (52)         (50)         (49)         (51)                                   
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
   Uterus                                             (51)         (52)         (52)         (52)                                   
      Deciduoma Benign                                                                        1 (2%)                                
      Polyp Stromal                                    9 (18%)     11 (21%)     10 (19%)      8 (15%)                               
                                                             Page   3                                                               
NTP Experiment-Test: 05704-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Sarcoma Stromal                                                                         1 (2%)                                
   Vagina                                             (2)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (48)                                   
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Pancreatic, Histiocytic Sarcoma                                            1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (48)         (50)                                   
   Spleen                                             (50)         (50)         (51)         (50)                                   
   Thymus                                             (47)         (45)         (48)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (50)         (50)         (50)                                   
      Adenocarcinoma                                   1 (2%)       2 (4%)       1 (2%)       3 (6%)                                
      Adenoma                                          1 (2%)                                                                       
      Adenoma, Multiple                                                                       1 (2%)                                
      Fibroadenoma                                    23 (45%)     14 (28%)      9 (18%)      8 (16%)                               
      Fibroadenoma, Multiple                           3 (6%)                    3 (6%)       1 (2%)                                
   Skin                                               (50)         (50)         (51)         (50)                                   
      Keratoacanthoma                                                            1 (2%)                                             
      Epidermis, Basal Cell Adenoma                    1 (2%)       1 (2%)                                                          
      Epidermis, Squamous Cell Papilloma               1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Liposarcoma                              1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
   Spinal Cord                                                                               (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05704-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (1)                                    (1)                                    
      Carcinoma, Metastatic, Thyroid Gland             1 (100%)                                                                     
      Schwannoma Malignant, Metastatic, Salivary                                                                                    
          Glands                                                                              1 (100%)                              
   Lung                                               (50)         (50)         (51)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
   Nose                                               (49)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)                                                              
   Zymbal's Gland                                                               (2)                                                 
      Carcinoma                                                                  2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
   Urinary Bladder                                    (50)         (49)         (48)         (49)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(58)        *(53)        *(55)        *(57)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            14 (24%)     16 (30%)     11 (20%)     15 (26%)                               
      Lymphoma Malignant Mixed                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05704-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 18:48:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K                                  
                                                   CONTROL                   G            G                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            53          49          47          46                                       
     Total Primary Neoplasms                          107          89          87          76                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          44          39          36                                       
     Total Benign Neoplasms                            86          67          63          53                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          21          21          21                                       
     Total Malignant Neoplasms                         21          22          24          23                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       1           1                                       
     Total Metastatic Neoplasm                          3                       1           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
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