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TDMS Study 05704-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: IRDC                                                      RESORCINOL                                      DATE: 09/18/94       
EXPERIMENT: 05704 TEST: 03                                                                                     TIME: 18:56:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: 000000570004          ROUTE: GAVAGE                                                                      NTP C#: 05970B       
PATHOLOGIST: F. VOELKER                      S. EUSTIS                                                         CAS: 000108463       
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: IRDC                                                      RESORCINOL                                      DATE: 09/18/94      
EXPERIMENT: 05704 TEST: 03                                                                                     TIME: 18:56:17      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: 000000570004          ROUTE: GAVAGE                                                                      NTP C#: 05970B      
PATHOLOGIST: F. VOELKER                      S. EUSTIS                                                         CAS: 000108463      
 
 
 
 
 
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Salivary Glands
                                                    Spleen
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: IRDC                                                      RESORCINOL                                      DATE: 09/18/94       
EXPERIMENT: 05704 TEST: 03                                                                                     TIME: 18:56:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: 000000570004          ROUTE: GAVAGE                                                                      NTP C#: 05970B       
PATHOLOGIST: F. VOELKER                      S. EUSTIS                                                         CAS: 000108463       
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                           IN THE ANALYSIS OF THE STUDY OF RESORCINOL
 
              ====================================================================================================
 
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                             All Organs                    Benign Tumors
                                                           Malignant and Benign Tumors
                             Mammary Gland                 Fibroadenoma
                                                           Fibroma, Fibroadenoma or Adenoma
                                                           Fibroma, Fibroadenoma, Carcinoma, or Adenoma
 
              ====================================================================================================
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE   1
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Adrenal Medulla                                                               |
|     Pheochromocytoma Benign                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  1/56 (2%)    1/52 (2%)    6/50 (12%)   1/55 (2%)    |
|ADJUSTED (b)           |   3.0%         2.2%        16.6%         4.3%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  1/33 (3%)    0/33 (0%)    2/26 (8%)    1/23 (4%)    |
|FIRST INCIDENCE (DAYS) |   729 (T)      646          627          729 (T)     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.166      P=0.750N     P=0.045 *    P=0.679      |
|INCIDENTAL TUMOR       |  P=0.265      P=0.702N     P=0.061      P=0.679      |
|LOGISTIC REGRESSION    |  P=0.217      P=0.753      P=0.043 *    P=0.679      |
|COCHRAN-ARMITAGE       |  P=0.264                                             |
|FISHER EXACT           |               P=0.733      P=0.041 *    P=0.748      |
|==============================================================================|
|                                                                              |
|Adrenal Medulla                                                               |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                        |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  2/56 (4%)    1/52 (2%)    6/50 (12%)   1/55 (2%)    |
|ADJUSTED (b)           |   6.1%         2.2%        16.6%         4.3%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  2/33 (6%)    0/33 (0%)    2/26 (8%)    1/23 (4%)    |
|FIRST INCIDENCE (DAYS) |   729 (T)      646          627          729 (T)     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.298      P=0.489N     P=0.100      P=0.626N     |
|INCIDENTAL TUMOR       |  P=0.419      P=0.439N     P=0.131      P=0.626N     |
|LOGISTIC REGRESSION    |  P=0.365      P=0.504N     P=0.102      P=0.626N     |
|COCHRAN-ARMITAGE       |  P=0.430                                             |
|FISHER EXACT           |               P=0.528N     P=0.101      P=0.507N     |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE   2
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Clitoral/Preputial Gland                                                      |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  9/53 (17%)   8/44 (18%)   6/47 (13%)   4/55 (7%)    |
|ADJUSTED (b)           |  24.2%        23.7%        19.9%        15.3%        |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  6/33 (18%)   7/32 (22%)   4/26 (15%)   3/24 (13%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      663          662          689         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.206N     P=0.570N     P=0.466N     P=0.270N     |
|INCIDENTAL TUMOR       |  P=0.151N     P=0.545N     P=0.400N     P=0.204N     |
|LOGISTIC REGRESSION    |  P=0.136N     P=0.599N     P=0.402N     P=0.192N     |
|COCHRAN-ARMITAGE       |  P=0.061N                                            |
|FISHER EXACT           |               P=0.543      P=0.381N     P=0.104N     |
|==============================================================================|
|                                                                              |
|Clitoral/Preputial Gland                                                      |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  0/53 (0%)    0/44 (0%)    3/47 (6%)    0/55 (0%)    |
|ADJUSTED (b)           |   0.0%         0.0%         8.4%         0.0%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  0/33 (0%)    0/32 (0%)    1/26 (4%)    0/24 (0%)    |
|FIRST INCIDENCE (DAYS) |   ---          ---          623          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.240        (e)        P=0.107        (e)        |
|INCIDENTAL TUMOR       |  P=0.357        (e)        P=0.131        (e)        |
|LOGISTIC REGRESSION    |  P=0.299        (e)        P=0.100        (e)        |
|COCHRAN-ARMITAGE       |  P=0.319                                             |
|FISHER EXACT           |                 (e)        P=0.100        (e)        |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE   3
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Clitoral/Preputial Gland                                                      |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  9/53 (17%)   8/44 (18%)   9/47 (19%)   4/55 (7%)    |
|ADJUSTED (b)           |  24.2%        23.7%        27.2%        15.3%        |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  6/33 (18%)   7/32 (22%)   5/26 (19%)   3/24 (13%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      663          623          689         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.324N     P=0.570N     P=0.417      P=0.270N     |
|INCIDENTAL TUMOR       |  P=0.223N     P=0.545N     P=0.496      P=0.204N     |
|LOGISTIC REGRESSION    |  P=0.219N     P=0.599N     P=0.468      P=0.192N     |
|COCHRAN-ARMITAGE       |  P=0.109N                                            |
|FISHER EXACT           |               P=0.543      P=0.490      P=0.104N     |
|==============================================================================|
|                                                                              |
|Mammary Gland                                                                 |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  1/58 (2%)    2/53 (4%)    1/55 (2%)    3/57 (5%)    |
|ADJUSTED (b)           |   2.9%         5.9%         3.6%         9.7%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  1/34 (3%)    1/33 (3%)    1/28 (4%)    1/24 (4%)    |
|FIRST INCIDENCE (DAYS) |   729 (T)      716          729 (T)      601         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.158      P=0.486      P=0.718      P=0.217      |
|INCIDENTAL TUMOR       |  P=0.209      P=0.549      P=0.718      P=0.272      |
|LOGISTIC REGRESSION    |  P=0.183      P=0.494      P=0.718      P=0.242      |
|COCHRAN-ARMITAGE       |  P=0.247                                             |
|FISHER EXACT           |               P=0.466      P=0.739      P=0.303      |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE   4
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Mammary Gland                                                                 |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  2/58 (3%)    2/53 (4%)    1/55 (2%)    3/57 (5%)    |
|ADJUSTED (b)           |   5.9%         5.9%         3.6%         9.7%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  2/34 (6%)    1/33 (3%)    1/28 (4%)    1/24 (4%)    |
|FIRST INCIDENCE (DAYS) |   729 (T)      716          729 (T)      601         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.308      P=0.680      P=0.568N     P=0.372      |
|INCIDENTAL TUMOR       |  P=0.376      P=0.659N     P=0.568N     P=0.433      |
|LOGISTIC REGRESSION    |  P=0.346      P=0.687      P=0.568N     P=0.409      |
|COCHRAN-ARMITAGE       |  P=0.435                                             |
|FISHER EXACT           |               P=0.656      P=0.520N     P=0.492      |
|==============================================================================|
|                                                                              |
|Mammary Gland                                                                 |
|     Fibroadenoma                                                             |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 26/58 (45%)  14/53 (26%)  12/55 (22%)   9/57 (16%)   |
|ADJUSTED (b)           |  59.8%        40.8%        38.1%        33.1%        |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           | 17/34 (50%)  13/33 (39%)   9/28 (32%)   6/24 (25%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      673          662          694         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.008N**   P=0.026N*    P=0.033N*    P=0.020N*    |
|INCIDENTAL TUMOR       |  P=0.002N**   P=0.034N*    P=0.007N**   P=0.003N**   |
|LOGISTIC REGRESSION    |  P=0.002N**   P=0.015N*    P=0.007N**   P=0.004N**   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                          |
|FISHER EXACT           |               P=0.034N*    P=0.008N**   P<0.001N**   |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE   5
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Mammary Gland                                                                 |
|     Fibroma, Fibroadenoma or Adenoma                                         |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 26/58 (45%)  14/53 (26%)  12/55 (22%)  10/57 (18%)   |
|ADJUSTED (b)           |  59.8%        40.8%        38.1%        35.2%        |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           | 17/34 (50%)  13/33 (39%)   9/28 (32%)   6/24 (25%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      673          662          689         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.015N*    P=0.026N*    P=0.033N*    P=0.036N*    |
|INCIDENTAL TUMOR       |  P=0.003N**   P=0.034N*    P=0.007N**   P=0.006N**   |
|LOGISTIC REGRESSION    |  P=0.003N**   P=0.015N*    P=0.007N**   P=0.008N**   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                          |
|FISHER EXACT           |               P=0.034N*    P=0.008N**   P=0.001N**   |
|==============================================================================|
|                                                                              |
|Mammary Gland                                                                 |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                             |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 27/58 (47%)  16/53 (30%)  13/55 (24%)  11/57 (19%)   |
|ADJUSTED (b)           |  62.1%        45.4%        41.3%        36.9%        |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           | 18/34 (53%)  14/33 (42%)  10/28 (36%)   6/24 (25%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      673          662          601         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.019N*    P=0.044N*    P=0.037N*    P=0.043N*    |
|INCIDENTAL TUMOR       |  P=0.004N**   P=0.051N     P=0.008N**   P=0.007N**   |
|LOGISTIC REGRESSION    |  P=0.004N**   P=0.024N*    P=0.008N**   P=0.009N**   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                          |
|FISHER EXACT           |               P=0.058N     P=0.009N**   P=0.002N**   |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE   6
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Pituitary Gland: Pars Distalis or Unspecified Site                            |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            | 28/57 (49%)  27/53 (51%)  21/55 (38%)  24/57 (42%)   |
|ADJUSTED (b)           |  67.2%        62.3%        54.2%        70.9%        |
|INTERIM SACRIFICE 1 (c)|  3/8 (38%)    1/3 (33%)    2/5 (40%)    1/7 (14%)    |
|TERMINAL (d)           | 20/33 (61%)  17/33 (52%)  12/28 (43%)  15/24 (63%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      457 (I)      430          323         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.402      P=0.509      P=0.382N     P=0.333      |
|INCIDENTAL TUMOR       |  P=0.340N     P=0.414N     P=0.199N     P=0.539N     |
|LOGISTIC REGRESSION    |  P=0.306N     P=0.567N     P=0.163N     P=0.543N     |
|COCHRAN-ARMITAGE       |  P=0.143N                                            |
|FISHER EXACT           |               P=0.500      P=0.164N     P=0.286N     |
|==============================================================================|
|                                                                              |
|Pituitary Gland: Pars Distalis or Unspecified Site                            |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            | 29/57 (51%)  27/53 (51%)  22/55 (40%)  24/57 (42%)   |
|ADJUSTED (b)           |  67.9%        62.3%        55.4%        70.9%        |
|INTERIM SACRIFICE 1 (c)|  3/8 (38%)    1/3 (33%)    2/5 (40%)    1/7 (14%)    |
|TERMINAL (d)           | 20/33 (61%)  17/33 (52%)  12/28 (43%)  15/24 (63%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      457 (I)      430          323         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.439      P=0.561N     P=0.389N     P=0.397      |
|INCIDENTAL TUMOR       |  P=0.282N     P=0.354N     P=0.181N     P=0.438N     |
|LOGISTIC REGRESSION    |  P=0.259N     P=0.505N     P=0.166N     P=0.455N     |
|COCHRAN-ARMITAGE       |  P=0.118N                                            |
|FISHER EXACT           |               P=0.573      P=0.167N     P=0.226N     |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE   7
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,             |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma        |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  2/58 (3%)    1/53 (2%)    2/55 (4%)    0/57 (0%)    |
|ADJUSTED (b)           |   5.9%         2.3%         5.4%         0.0%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     1/5 (20%)    0/7 (0%)     |
|TERMINAL (d)           |  2/34 (6%)    0/33 (0%)    1/28 (4%)    0/24 (0%)    |
|FIRST INCIDENCE (DAYS) |   729 (T)      663          457 (I)      ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.283N     P=0.496N     P=0.597      P=0.318N     |
|INCIDENTAL TUMOR       |  P=0.265N     P=0.451N     P=0.597      P=0.318N     |
|LOGISTIC REGRESSION    |  P=0.219N     P=0.508N     P=0.676      P=0.318N     |
|COCHRAN-ARMITAGE       |  P=0.213N                                            |
|FISHER EXACT           |               P=0.534N     P=0.671      P=0.252N     |
|==============================================================================|
|                                                                              |
|Skin: Subcutaneous Tissue                                                     |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                |
|     Neurofibroma, or Fibroma                                                 |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  1/58 (2%)    1/53 (2%)    2/55 (4%)    0/57 (0%)    |
|ADJUSTED (b)           |   2.9%         2.4%         6.3%         0.0%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  1/34 (3%)    0/33 (0%)    1/28 (4%)    0/24 (0%)    |
|FIRST INCIDENCE (DAYS) |   729 (T)      674          678          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.498N     P=0.760      P=0.440      P=0.569N     |
|INCIDENTAL TUMOR       |  P=0.452N     P=0.711N     P=0.502      P=0.569N     |
|LOGISTIC REGRESSION    |  P=0.469N     P=0.755      P=0.471      P=0.569N     |
|COCHRAN-ARMITAGE       |  P=0.413N                                            |
|FISHER EXACT           |               P=0.729      P=0.480      P=0.504N     |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE   8
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Thyroid Gland: C-Cell                                                         |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  2/58 (3%)    3/52 (6%)    4/55 (7%)    4/56 (7%)    |
|ADJUSTED (b)           |   5.6%         8.4%        14.3%        13.9%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     1/7 (14%)    |
|TERMINAL (d)           |  1/34 (3%)    2/33 (6%)    4/28 (14%)   2/24 (8%)    |
|FIRST INCIDENCE (DAYS) |   717          674          729 (T)      457 (I)     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.113      P=0.486      P=0.249      P=0.211      |
|INCIDENTAL TUMOR       |  P=0.135      P=0.565      P=0.294      P=0.269      |
|LOGISTIC REGRESSION    |  P=0.144      P=0.491      P=0.263      P=0.261      |
|COCHRAN-ARMITAGE       |  P=0.218                                             |
|FISHER EXACT           |               P=0.448      P=0.314      P=0.323      |
|==============================================================================|
|                                                                              |
|Thyroid Gland: C-Cell                                                         |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  2/58 (3%)    1/52 (2%)    0/55 (0%)    1/56 (2%)    |
|ADJUSTED (b)           |   5.6%         3.0%         0.0%         4.2%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  1/34 (3%)    1/33 (3%)    0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE (DAYS) |   717          729 (T)      ---          729 (T)     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.342N     P=0.517N     P=0.290N     P=0.626N     |
|INCIDENTAL TUMOR       |  P=0.305N     P=0.460N     P=0.215N     P=0.567N     |
|LOGISTIC REGRESSION    |  P=0.324N     P=0.508N     P=0.264N     P=0.605N     |
|COCHRAN-ARMITAGE       |  P=0.256N                                            |
|FISHER EXACT           |               P=0.541N     P=0.261N     P=0.513N     |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE   9
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Thyroid Gland: C-Cell                                                         |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  3/58 (5%)    4/52 (8%)    4/55 (7%)    4/56 (7%)    |
|ADJUSTED (b)           |   8.5%        11.3%        14.3%        13.9%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     1/7 (14%)    |
|TERMINAL (d)           |  2/34 (6%)    3/33 (9%)    4/28 (14%)   2/24 (8%)    |
|FIRST INCIDENCE (DAYS) |   717          674          729 (T)      457 (I)     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.234      P=0.484      P=0.390      P=0.335      |
|INCIDENTAL TUMOR       |  P=0.268      P=0.551      P=0.440      P=0.401      |
|LOGISTIC REGRESSION    |  P=0.285      P=0.492      P=0.409      P=0.397      |
|COCHRAN-ARMITAGE       |  P=0.397                                             |
|FISHER EXACT           |               P=0.439      P=0.470      P=0.480      |
|==============================================================================|
|                                                                              |
|Thyroid Gland: Follicular Cell                                                |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  2/58 (3%)    0/52 (0%)    1/55 (2%)    1/56 (2%)    |
|ADJUSTED (b)           |   5.6%         0.0%         3.6%         3.3%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  1/34 (3%)    0/33 (0%)    1/28 (4%)    0/24 (0%)    |
|FIRST INCIDENCE (DAYS) |   717          ---          729 (T)      690         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.514N     P=0.253N     P=0.574N     P=0.616N     |
|INCIDENTAL TUMOR       |  P=0.448N     P=0.199N     P=0.498N     P=0.513N     |
|LOGISTIC REGRESSION    |  P=0.485N     P=0.241N     P=0.549N     P=0.588N     |
|COCHRAN-ARMITAGE       |  P=0.417N                                            |
|FISHER EXACT           |               P=0.276N     P=0.520N     P=0.513N     |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE  10
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Thyroid Gland: Follicular Cell                                                |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  2/58 (3%)    0/52 (0%)    1/55 (2%)    0/56 (0%)    |
|ADJUSTED (b)           |   5.1%         0.0%         3.6%         0.0%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  1/34 (3%)    0/33 (0%)    1/28 (4%)    0/24 (0%)    |
|FIRST INCIDENCE (DAYS) |   629          ---          729 (T)      ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.199N     P=0.236N     P=0.553N     P=0.308N     |
|INCIDENTAL TUMOR       |  P=0.171N     P=0.399N     P=0.524N     P=0.278N     |
|LOGISTIC REGRESSION    |  P=0.175N     P=0.259N     P=0.522N     P=0.275N     |
|COCHRAN-ARMITAGE       |  P=0.155N                                            |
|FISHER EXACT           |               P=0.276N     P=0.520N     P=0.257N     |
|==============================================================================|
|                                                                              |
|Thyroid Gland: Follicular Cell                                                |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  4/58 (7%)    0/52 (0%)    2/55 (4%)    1/56 (2%)    |
|ADJUSTED (b)           |  10.6%         0.0%         7.1%         3.3%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  2/34 (6%)    0/33 (0%)    2/28 (7%)    0/24 (0%)    |
|FIRST INCIDENCE (DAYS) |   629          ---          729 (T)      690         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.242N     P=0.069N     P=0.425N     P=0.293N     |
|INCIDENTAL TUMOR       |  P=0.179N     P=0.090N     P=0.353N     P=0.209N     |
|LOGISTIC REGRESSION    |  P=0.204N     P=0.069N     P=0.373N     P=0.251N     |
|COCHRAN-ARMITAGE       |  P=0.158N                                            |
|FISHER EXACT           |               P=0.073N     P=0.365N     P=0.193N     |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE  11
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Uterus                                                                        |
|     Polyp Stromal                                                            |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  9/58 (16%)  11/53 (21%)  10/55 (18%)   8/57 (14%)   |
|ADJUSTED (b)           |  22.6%        28.7%        30.5%        29.5%        |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    2/3 (67%)    0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  6/34 (18%)   8/33 (24%)   7/28 (25%)   6/24 (25%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      457 (I)      430          601         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.360      P=0.264      P=0.345      P=0.441      |
|INCIDENTAL TUMOR       |  P=0.498      P=0.144      P=0.413      P=0.521      |
|LOGISTIC REGRESSION    |  P=0.524N     P=0.313      P=0.447      P=0.549      |
|COCHRAN-ARMITAGE       |  P=0.412N                                            |
|FISHER EXACT           |               P=0.319      P=0.449      P=0.516N     |
|==============================================================================|
|                                                                              |
|Uterus                                                                        |
|     Sarcoma Stromal or Polyp Stromal                                         |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  9/58 (16%)  11/53 (21%)  10/55 (18%)   9/57 (16%)   |
|ADJUSTED (b)           |  22.6%        28.7%        30.5%        31.0%        |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    2/3 (67%)    0/5 (0%)     1/7 (14%)    |
|TERMINAL (d)           |  6/34 (18%)   8/33 (24%)   7/28 (25%)   6/24 (25%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      457 (I)      430          457 (I)     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.276      P=0.264      P=0.345      P=0.338      |
|INCIDENTAL TUMOR       |  P=0.403      P=0.144      P=0.413      P=0.410      |
|LOGISTIC REGRESSION    |  P=0.464      P=0.313      P=0.447      P=0.466      |
|COCHRAN-ARMITAGE       |  P=0.505N                                            |
|FISHER EXACT           |               P=0.319      P=0.449      P=0.585      |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE  12
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|Zymbal's Gland                                                                |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  0/58 (0%)    0/53 (0%)    2/55 (4%)    0/57 (0%)    |
|ADJUSTED (b)           |   0.0%         0.0%         5.2%         0.0%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  0/34 (0%)    0/33 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE (DAYS) |   ---          ---          637          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.327        (e)        P=0.223        (e)        |
|INCIDENTAL TUMOR       |  P=0.436        (e)        P=0.306        (e)        |
|LOGISTIC REGRESSION    |  P=0.369        (e)        P=0.226        (e)        |
|COCHRAN-ARMITAGE       |  P=0.376                                             |
|FISHER EXACT           |                 (e)        P=0.235        (e)        |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                           |
|     or Undifferentiated                                                      |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 14/58 (24%)  16/53 (30%)  11/55 (20%)  15/57 (26%)   |
|ADJUSTED (b)           |  34.9%        38.5%        28.8%        41.5%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     0/7 (0%)     |
|TERMINAL (d)           |  9/34 (26%)   9/33 (27%)   3/28 (11%)   5/24 (21%)   |
|FIRST INCIDENCE (DAYS) |   509          472          579          303         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.248      P=0.400      P=0.490N     P=0.202      |
|INCIDENTAL TUMOR       |  P=0.456N     P=0.404      P=0.236N     P=0.493      |
|LOGISTIC REGRESSION    |  P=0.442      P=0.348      P=0.285N     P=0.339      |
|COCHRAN-ARMITAGE       |  P=0.480N                                            |
|FISHER EXACT           |               P=0.307      P=0.382N     P=0.478      |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE  13
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Benign Tumors                                                            |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 47/58 (81%)  44/53 (83%)  39/55 (71%)  36/57 (63%)   |
|ADJUSTED (b)           |  93.9%        91.5%        90.2%        91.9%        |
|INTERIM SACRIFICE 1 (c)|  4/8 (50%)    3/3 (100%)   3/5 (60%)    3/7 (43%)    |
|TERMINAL (d)           | 31/34 (91%)  29/33 (88%)  24/28 (86%)  21/24 (88%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      457 (I)      430          323         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.451      P=0.495      P=0.566      P=0.468      |
|INCIDENTAL TUMOR       |  P=0.098N     P=0.525      P=0.187N     P=0.186N     |
|LOGISTIC REGRESSION    |  P=0.076N     P=0.590      P=0.136N     P=0.205N     |
|COCHRAN-ARMITAGE       |  P=0.007N**                                          |
|FISHER EXACT           |               P=0.491      P=0.149N     P=0.026N*    |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Malignant Tumors                                                         |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 20/58 (34%)  21/53 (40%)  21/55 (38%)  21/57 (37%)   |
|ADJUSTED (b)           |  46.7%        48.1%        48.4%        51.9%        |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/3 (0%)     0/5 (0%)     1/7 (14%)    |
|TERMINAL (d)           | 12/34 (35%)  11/33 (33%)   7/28 (25%)   6/24 (25%)   |
|FIRST INCIDENCE (DAYS) |   509          472          463          303         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.121      P=0.470      P=0.313      P=0.164      |
|INCIDENTAL TUMOR       |  P=0.492      P=0.493      P=0.531N     P=0.488      |
|LOGISTIC REGRESSION    |  P=0.234      P=0.456      P=0.531      P=0.318      |
|COCHRAN-ARMITAGE       |  P=0.442                                             |
|FISHER EXACT           |               P=0.358      P=0.416      P=0.472      |
|==============================================================================|
 
         DATE: 09/18/94                     EXPERIMENT: 05704 TEST: 03                                                 PAGE  14
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- RESORCINOL
 
                       TERMINAL SACRIFICE AT 105 WEEKS
 
|==============================================================================|
|DOSE                   |   VEHICLE/     50 MG/KG     100 MG/K     150 MG/K    |
|                       |   CONTROL                   G            G           |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Malignant and Benign Tumors                                              |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 53/58 (91%)  49/53 (92%)  47/55 (85%)  46/57 (81%)   |
|ADJUSTED (b)           |  98.1%        94.2%        92.1%        95.8%        |
|INTERIM SACRIFICE 1 (c)|  4/8 (50%)    3/3 (100%)   3/5 (60%)    4/7 (57%)    |
|TERMINAL (d)           | 33/34 (97%)  30/33 (91%)  24/28 (86%)  22/24 (92%)   |
|FIRST INCIDENCE (DAYS) |   457 (I)      457 (I)      430          303         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.134      P=0.555      P=0.396      P=0.167      |
|INCIDENTAL TUMOR       |  P=0.150N     P=0.640      P=0.131N     P=0.304N     |
|LOGISTIC REGRESSION    |  P=0.251N     P=0.610      P=0.231N     P=0.572N     |
|COCHRAN-ARMITAGE       |  P=0.030N*                                           |
|FISHER EXACT           |               P=0.557      P=0.245N     P=0.082N     |
|==============================================================================|
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):  
          Female interim sacrifices(days): 457
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).