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TDMS Study 05704-03 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: IRDC                                                      DATE: 09/18/94   
EXP: 05704                       RESORCINOL                    TIME: 18:56:24   
TEST: 03              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 05970B   
CONT: 000000570004                                             CAS: 000108463   
PATHOLOGIST: F. VOELKER                      S. EUSTIS                          
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REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: IRDC                                                      DATE: 09/18/94  
EXP: 05704                       RESORCINOL                    TIME: 18:56:24  
TEST: 03              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 05970B  
CONT: 000000570004                                             CAS: 000108463  
PATHOLOGIST: F. VOELKER                      S. EUSTIS                         

                                    RESORCINOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE/CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 10   TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      509   521   545   561   579   623   629   630   653   662                 |
 |      688   693   693   695   717   717                                         |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 11   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      101   472   524   629   646   656   663   668   673   674                 |
 |      674   678   680   681   693   699                                         |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |      716                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 MG/KG                                |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      430   455   463   524   579   608   623   627   627   637                 |
 |      646   662   666   673   674   678   688   689   702   712                 |
 |      716   716                                                                 |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================

                                    RESORCINOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 150 MG/KG                                |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 25     CENSORED DEATHS 11   TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      218   290   303   310   323   385   386   434   444   447                 |
 |      573   601   618   621   624   631   658   678   689   690                 |
 |      694   695   702   702   716                                               |
 |  CENSORED DEATHS                                                               |
 |      213   457   457   457   457   457   457   457   457   457                 |
 |      457                                                                       |
 |                                                                                |
 ==================================================================================

                                    RESORCINOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE/CON|ROL100.0 100.0 100.0 100.0 100.0 100.0  94.0  90.0  80.0  68.0      |
 |V          |                                                                    |
 |           |                                                                    |
 |50 MG/KG   |   100.0  98.3  98.3  98.3  98.3  96.3  94.3  94.3  86.3  68.2      |
 |           |                                                                    |
 |           |                                                                    |
 |100 MG/KG  |   100.0 100.0 100.0 100.0 100.0  94.7  92.6  90.6  76.5  56.4      |
 |           |                                                                    |
 |           |                                                                    |
 |150 MG/KG  |   100.0 100.0  98.3  91.5  88.1  83.1  83.1  78.8  68.1  51.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE/CONTR50 MG/KG     100 MG/KG    150 MG/KG|
 |                                V                                               |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.0%        68.2%        56.4%        51.1%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.017      P=1.000      P=0.281      P=0.051  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       632.2        613.2        627.0        537.3    |
 |NATURAL DEATHS (C)      |       (17.5)       (37.5)       (18.3)       (32.7)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       657.9        652.6        646.3        595.2    |
 |(STANDARD ERROR)        |       (13.6)       (16.3)       (14.2)       (20.5)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)