Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/5225

TDMS Study 05704-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             RESORCINOL


NTP Experiment-Test: 05704-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 17:00:58




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108-46-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            9           11                                                  
    Moribund                                           2            8            5                                                  
    Accident                                           1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           33           34                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)                      (49)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                                                   1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                                                                       
      Perforation                                      1 (2%)                                                                       
   Gallbladder                                        (43)                      (39)                                                
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
   Intestine Large                                    (50)         (1)          (50)                                                
      Anorectal Junction, Inflammation, Chronic,                                                                                    
           Focal                                                                 2 (4%)                                             
   Intestine Large, Cecum                             (48)         (1)          (44)                                                
      Parasite Metazoan                                1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Diffuse                        1 (100%)                                                        
   Intestine Large, Colon                             (50)         (1)          (48)                                                
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  1 (2%)                                                                       
      Parasite Metazoan                                1 (2%)                                                                       
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Diffuse                        1 (100%)                                                        
   Intestine Small, Duodenum                          (47)         (2)          (42)                                                
      Hyperplasia, Atypical, Focal                                  1 (50%)                                                         
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Diffuse                        1 (50%)                                                         
   Intestine Small, Ileum                             (44)         (1)          (41)                                                
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
   Intestine Small, Jejunum                           (47)         (2)          (42)                                                
      Diverticulum                                                  1 (50%)      1 (2%)                                             
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Serosa, Inflammation, Chronic, Diffuse                        1 (50%)                                                         
   Liver                                              (50)         (5)          (50)                                                
      Erythrophagocytosis, Diffuse                                               3 (6%)                                             
      Fatty Change, Diffuse                                                      2 (4%)                                             
      Hematopoietic Cell Proliferation, Diffuse                     1 (20%)                                                         
      Hematopoietic Cell Proliferation, Multifocal     2 (4%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 13 (26%)                   9 (18%)                                            
      Inflammation, Focal, Subacute                                              1 (2%)                                             
      Necrosis, Acute, Focal                           1 (2%)                    1 (2%)                                             
      Necrosis, Focal, Subacute                        1 (2%)                                                                       
      Pigmentation, Diffuse, Hemosiderin                                         2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Centrilobular, Fatty Change                      2 (4%)                    1 (2%)                                             
      Periportal, Fatty Change                         1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Focal                          1 (20%)                                                         
      Serosa, Inflammation, Subacute                   1 (2%)                                                                       
   Mesentery                                          (1)          (1)          (2)                                                 
      Cyst                                                          1 (100%)                                                        
      Fat, Necrosis                                    1 (100%)     1 (100%)                                                        
   Pancreas                                           (48)                      (48)                                                
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Cyst                                             2 (4%)                                                                       
      Hyperplasia, Focal, Glandular                    2 (4%)                                                                       
      Hyperplasia, Glandular, Multifocal                                         1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)                                                                       
   Salivary Glands                                    (48)                      (47)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         4 (8%)                    1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 13 (27%)                  22 (47%)                                            
      Infiltration Cellular, Multifocal, Plasma                                                                                     
          Cell                                         1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (3)          (46)                                                
      Hyperplasia, Focal, Squamous                     1 (2%)       1 (33%)      5 (11%)                                            
      Hyperplasia, Multifocal                          1 (2%)                                                                       
      Hyperplasia, Multifocal, Squamous                2 (4%)       1 (33%)      1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Subacute                                                     1 (2%)                                             
      Ulcer, Acute, Multifocal                                                   2 (4%)                                             
   Stomach, Glandular                                 (50)                      (46)                                                
      Cyst                                             1 (2%)                                                                       
      Erosion, Focal                                                             2 (4%)                                             
      Erosion, Multifocal                              1 (2%)                                                                       
      Ulcer, Acute, Focal                                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Tooth                                              (1)                       (1)                                                 
      Inflammation, Chronic                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)          (49)                                                
      Coronary Artery, Hyperplasia, Chronic,                                                                                        
          Multifocal                                   1 (2%)                                                                       
      Epicardium, Inflammation, Diffuse, Subacute                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)                      (49)                                                
      Congestion, Focal                                1 (2%)                                                                       
      Hypertrophy, Focal                                                         1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Vacuolization Cytoplasmic, Multifocal            2 (4%)                                                                       
      Spindle Cell, Hyperplasia                        1 (2%)                                                                       
   Parathyroid Gland                                  (24)                      (20)                                                
      Cyst                                                                       1 (5%)                                             
      Infiltration Cellular, Focal, Plasma Cell        1 (4%)                                                                       
   Pituitary Gland                                    (48)         (7)          (50)                                                
      Pars Distalis, Congestion, Diffuse                            1 (14%)                                                         
      Pars Distalis, Ectasia, Focal                    1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                9 (19%)      1 (14%)     10 (20%)                                            
      Pars Distalis, Hyperplasia, Multifocal           1 (2%)                    2 (4%)                                             
   Thyroid Gland                                      (49)                      (49)                                                
      Depletion Secretory                              1 (2%)                    1 (2%)                                             
      Follicular Cell, Hyperplasia                     5 (10%)                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (11)         (49)                                                
      Abscess                                          2 (4%)                                                                       
      Angiectasis, Focal                                                         1 (2%)                                             
      Cyst                                             3 (6%)       8 (73%)      7 (14%)                                            
      Cyst Multilocular                                6 (12%)      4 (36%)      4 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                       3 (6%)                                                                       
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  2 (4%)                    3 (6%)                                             
   Uterus                                             (50)         (36)         (50)                                                
      Abscess                                          1 (2%)                                                                       
      Amyloid Deposition, Diffuse                                                1 (2%)                                             
      Dilatation                                       2 (4%)                    1 (2%)                                             
      Hemorrhage, Chronic                                           1 (3%)       1 (2%)                                             
      Hyperplasia, Chronic, Cystic, Diffuse           41 (82%)     35 (97%)     41 (82%)                                            
      Hyperplasia, Diffuse, Lymphoid                   1 (2%)                                                                       
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Diffuse                        1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                      (50)                                                
      Myelofibrosis                                    2 (4%)                                                                       
      Pigmentation, Diffuse, Hemosiderin                                         2 (4%)                                             
   Lymph Node                                         (50)         (7)          (50)                                                
      Axillary, Infiltration Cellular, Diffuse,                                                                                     
           Plasma Cell                                 1 (2%)                                                                       
      Iliac, Hematopoietic Cell Proliferation,                                                                                      
           Diffuse                                     1 (2%)                                                                       
      Iliac, Hyperplasia, Diffuse, Lymphoid            2 (4%)                                                                       
      Mediastinal, Infiltration Cellular, Diffuse,                                                                                  
           Plasma Cell                                 1 (2%)                                                                       
      Renal, Hyperplasia, Diffuse, Lymphoid            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (47)         (6)          (48)                                                
      Giant Cell, Diffuse                              1 (2%)                                                                       
      Hematopoietic Cell Proliferation, Diffuse                                  1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
      Infiltration Cellular, Diffuse, Histiocyte       1 (2%)                                                                       
   Spleen                                             (50)         (12)         (49)                                                
      Congestion, Diffuse                                                        2 (4%)                                             
      Erythrophagocytosis, Diffuse                                               3 (6%)                                             
      Hematopoietic Cell Proliferation, Diffuse        5 (10%)      2 (17%)      7 (14%)                                            
      Hyperplasia, Diffuse, Lymphoid                   1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                    3 (6%)                                             
      Capsule, Inflammation, Acute                     1 (2%)                                                                       
   Thymus                                             (43)         (1)          (39)                                                
      Atrophy, Diffuse                                                           3 (8%)                                             
      Medulla, Hyperplasia, Focal, Lymphoid            6 (14%)                   4 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (1)          (48)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
   Skin                                               (49)         (6)          (50)                                                
      Inflammation, Chronic                            1 (2%)       3 (50%)      7 (14%)                                            
      Subcutaneous Tissue, Necrosis                                 1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                      (50)                                                
      Hyperostosis                                     2 (4%)                                                                       
      Osteoporosis                                     1 (2%)                    1 (2%)                                             
   Skeletal Muscle                                                 (1)                                                              
      Hemorrhage, Acute                                             1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)                      (50)                                                
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  1 (2%)                                                                       
      Mineralization, Multifocal                      21 (43%)                  19 (38%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (7)          (49)                                                
      Abscess                                                       1 (14%)                                                         
      Atelectasis, Diffuse                                          1 (14%)                                                         
      Congestion, Diffuse                              1 (2%)       2 (29%)      3 (6%)                                             
      Foreign Body                                                  1 (14%)                                                         
      Hyperplasia, Focal, Adenomatous                  1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Diffuse, Histiocyte       1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 35 (70%)                  35 (71%)                                            
      Alveolus, Infiltration Cellular, Histiocyte                   1 (14%)                                                         
      Bronchiole, Inflammation, Acute                               1 (14%)                                                         
      Mediastinum, Bacterium                           1 (2%)                                                                       
      Mediastinum, Inflammation, Chronic,                                                                                           
          Multifocal                                   1 (2%)                                                                       
   Nose                                               (50)                      (50)                                                
      Foreign Body                                     2 (4%)                    1 (2%)                                             
      Inflammation, Acute                              3 (6%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)                                                 
      Degeneration, Chronic, Diffuse                   1 (50%)                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (3)          (50)                                                
      Casts                                                                      3 (6%)                                             
      Cyst                                                                       2 (4%)                                             
      Hydronephrosis                                                             3 (6%)                                             
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 34 (68%)                  32 (64%)                                            
      Nephropathy, Diffuse                                          1 (33%)      3 (6%)                                             
      Glomerulus, Amyloid Deposition, Diffuse          1 (2%)                    1 (2%)                                             
      Papilla, Mineralization, Multifocal                                        1 (2%)                                             
   Urinary Bladder                                    (48)                      (45)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell                                    1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  6 (13%)                   5 (11%)                                            
      Inflammation, Diffuse, Subacute                                            1 (2%)                                             
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           6            4            3                                                  
    Dead                                               6            3           12                                                  
    Accident                                           1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           43           34                                                  
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)                      (49)                                                
      Serosa, Inflammation, Subacute                                             1 (2%)                                             
   Gallbladder                                        (41)                      (39)                                                
      Cyst                                                                       1 (3%)                                             
   Intestine Large, Cecum                             (49)                      (45)                                                
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Large, Colon                             (48)                      (47)                                                
      Parasite Metazoan                                2 (4%)                                                                       
   Intestine Large, Rectum                            (47)                      (49)                                                
      Inflammation, Acute, Focal                                                 1 (2%)                                             
   Intestine Small                                    (50)         (5)          (50)                                                
      Diverticulum                                                  1 (20%)                                                         
   Intestine Small, Duodenum                          (47)         (2)          (43)                                                
      Amyloid Deposition, Chronic, Diffuse                                       1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (4)          (43)                                                
      Diverticulum                                     1 (2%)       3 (75%)                                                         
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
   Liver                                              (50)         (16)         (50)                                                
      Basophilic Focus                                 3 (6%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                                                                       
      Inclusion Body Intranuclear, Diffuse             1 (2%)                                                                       
      Infarct                                          1 (2%)       1 (6%)                                                          
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                                                   1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Karyomegaly, Diffuse                             1 (2%)                                                                       
      Mixed Cell Focus                                              1 (6%)       2 (4%)                                             
      Necrosis, Acute, Focal                           2 (4%)                                                                       
      Necrosis, Acute, Multifocal                                                1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Fatty Change                      2 (4%)                    2 (4%)                                             
      Centrilobular, Necrosis, Acute, Diffuse                                    1 (2%)                                             
   Pancreas                                           (50)                      (48)                                                
      Atrophy, Focal                                   1 (2%)                                                                       
      Edema, Acute, Diffuse                                                      1 (2%)                                             
      Hyperplasia, Focal, Glandular                                              1 (2%)                                             
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
   Salivary Glands                                    (50)                      (50)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         2 (4%)                    1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 17 (34%)                  16 (32%)                                            
   Stomach, Forestomach                               (49)                      (46)                                                
      Cyst                                             1 (2%)                                                                       
      Cyst Epithelial Inclusion                                                  2 (4%)                                             
      Diverticulum, Focal                              1 (2%)                                                                       
      Hyperplasia, Focal, Squamous                     2 (4%)                    2 (4%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                    2 (4%)                                             
   Stomach, Glandular                                 (47)                      (47)                                                
      Cyst, Focal                                      1 (2%)                                                                       
      Cyst Epithelial Inclusion, Focal                 1 (2%)                                                                       
      Degeneration, Cystic, Focal                      1 (2%)                                                                       
      Edema, Diffuse                                                             1 (2%)                                             
      Erosion, Focal                                   1 (2%)                                                                       
      Hyperplasia, Focal                                                         1 (2%)                                             
      Hyperplasia, Adenomatous                                                   1 (2%)                                             
   Tooth                                              (6)                       (1)                                                 
      Inflammation, Chronic                            6 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)          (50)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                                                   1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Atrium, Thrombosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (1)          (49)                                                
      Cytoplasmic Alteration, Focal                                              1 (2%)                                             
      Hyperplasia, Focal                               3 (6%)                    1 (2%)                                             
      Hypertrophy, Focal                               5 (10%)                   8 (16%)                                            
      Hypertrophy, Multifocal                          1 (2%)                                                                       
      Spindle Cell, Hyperplasia, Focal                 1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Gland, Medulla                             (47)                      (49)                                                
      Hyperplasia, Multifocal                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (1)          (47)                                                
      Hyperplasia, Focal                               3 (6%)                                                                       
   Parathyroid Gland                                  (20)                      (31)                                                
      Cyst                                                                       1 (3%)                                             
   Pituitary Gland                                    (45)                      (50)                                                
      Pars Distalis, Cyst                              2 (4%)                    3 (6%)                                             
   Thyroid Gland                                      (49)                      (50)                                                
      Cyst                                             1 (2%)                                                                       
      Depletion Secretory                                                        1 (2%)                                             
      Hemorrhage, Acute, Focal                                                   1 (2%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
      C-Cell, Hyperplasia, Chronic, Focal                                        1 (2%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)                      (50)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
   Penis                                              (1)                       (1)                                                 
      Congestion                                       1 (100%)                  1 (100%)                                           
      Inflammation, Chronic                            1 (100%)                                                                     
   Preputial Gland                                    (2)          (3)          (2)                                                 
      Abscess                                          1 (50%)      3 (100%)     1 (50%)                                            
      Inflammation, Chronic                            1 (50%)                   1 (50%)                                            
   Prostate                                           (49)                      (48)                                                
      Dilatation                                                                 1 (2%)                                             
   Seminal Vesicle                                                              (2)                                                 
      Dilatation                                                                 2 (100%)                                           
      Inflammation, Chronic, Diffuse                                             1 (50%)                                            
   Testes                                             (50)         (1)          (50)                                                
      Atrophy, Diffuse                                 1 (2%)       1 (100%)     1 (2%)                                             
      Degeneration, Diffuse                                                      1 (2%)                                             
      Granuloma Sperm, Focal                           1 (2%)                                                                       
      Mineralization, Focal                            2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (49)         (8)          (50)                                                
      Congestion                                                    1 (13%)                                                         
      Hematopoietic Cell Proliferation, Diffuse                                  1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Pigmentation                                                  1 (13%)                                                         
      Thrombosis                                                                 1 (2%)                                             
      Thoracic, Angiectasis                                         1 (13%)                                                         
   Lymph Node, Mesenteric                             (48)         (5)          (50)                                                
      Congestion, Diffuse                              5 (10%)                                                                      
      Ectasia, Diffuse                                                           3 (6%)                                             
      Giant Cell, Diffuse                              6 (13%)                   2 (4%)                                             
      Hematopoietic Cell Proliferation, Diffuse        2 (4%)                                                                       
      Hemorrhage, Diffuse                              2 (4%)                                                                       
      Hyperplasia, Diffuse, Re Cell                                              1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
   Spleen                                             (49)         (4)          (50)                                                
      Hematopoietic Cell Proliferation, Diffuse       10 (20%)      3 (75%)      4 (8%)                                             
      Hyperplasia, Lymphoid                                                      4 (8%)                                             
   Thymus                                             (24)                      (35)                                                
      Atrophy, Diffuse                                                           2 (6%)                                             
      Cyst                                             2 (8%)                    1 (3%)                                             
      Mediastinum, Inflammation, Acute                                           1 (3%)                                             
      Medulla, Hyperplasia, Focal, Lymphoid                                      1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (9)          (49)                                                
      Abscess                                          1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Edema, Acute, Diffuse                                                      1 (2%)                                             
      Inflammation, Chronic                            6 (12%)      3 (33%)      4 (8%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
      Hair Follicle, Atrophy, Focal                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                      (50)                                                
      Cartilage, Proliferation, Chronic, Focal                                   1 (2%)                                             
      Coccygeal, Hyperostosis                          1 (2%)                                                                       
      Cranium, Inflammation, Chronic                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                      (50)                                                
      Demyelination, Multifocal                        1 (2%)                                                                       
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hydrocephalus                                                              1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Mineralization, Multifocal                      24 (48%)                  24 (48%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (7)          (50)                                                
      Congestion, Diffuse                              2 (4%)                    5 (10%)                                            
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hemorrhage, Multifocal                                                     1 (2%)                                             
      Hyperplasia, Focal, Adenomatous                  4 (8%)       1 (14%)      1 (2%)                                             
      Infiltration Cellular, Diffuse, Histiocyte       1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 25 (50%)                  26 (52%)                                            
      Infiltration Cellular, Multifocal, Histiocyte                              1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Pleura, Inflammation, Subacute                                             1 (2%)                                             
   Nose                                               (50)                      (50)                                                
      Foreign Body                                     8 (16%)                   1 (2%)                                             
      Hyperplasia, Focal, Glandular                                              1 (2%)                                             
      Inflammation, Acute                              6 (12%)                   3 (6%)                                             
      Inflammation, Chronic                            2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (3)          (50)                                                
      Cyst                                             2 (4%)                    5 (10%)                                            
      Ectopic Tissue                                                             1 (2%)                                             
      Hyperplasia, Focal, Tubular                      1 (2%)                    1 (2%)                                             
      Hyperplasia, Multifocal, Tubular                                           1 (2%)                                             
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
           Multifocal                                 39 (78%)                  36 (72%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Nephropathy, Diffuse                             1 (2%)                    3 (6%)                                             
      Vacuolization Cytoplasmic, Multifocal                                      1 (2%)                                             
      Cortex, Degeneration, Diffuse, Hyaline           1 (2%)                    1 (2%)                                             
      Cortex, Vacuolization Cytoplasmic, Multifocal                              1 (2%)                                             
      Glomerulus, Amyloid Deposition, Diffuse                                    1 (2%)                                             
      Glomerulus, Inflammation, Diffuse, Subacute,                                                                                  
           Suppurative                                 1 (2%)                                                                       
      Proximal Convoluted Renal Tubule,                                                                                             
          Degeneration, Focal                                                    1 (2%)                                             
      Proximal Convoluted Renal Tubule, Dilatation,                                                                                 
           Diffuse                                                  1 (33%)                                                         
   Urinary Bladder                                    (49)                      (48)                                                
      Concretion                                       6 (12%)                   2 (4%)                                             
      Edema, Acute, Diffuse                                                      1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Inflammation, Acute, Diffuse                     1 (2%)                                                                       
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------