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TDMS Study 05704-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             RESORCINOL


NTP Experiment-Test: 05704-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 17:00:58




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108-46-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            9           11                                                  
    Moribund                                           2            8            5                                                  
    Accident                                           1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           33           34                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)                      (49)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                                                   1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                                                                       
      Perforation                                      1 (2%)                                                                       
   Gallbladder                                        (43)                      (39)                                                
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
   Intestine Large                                    (50)         (1)          (50)                                                
      Anorectal Junction, Inflammation, Chronic,                                                                                    
           Focal                                                                 2 (4%)                                             
   Intestine Large, Cecum                             (48)         (1)          (44)                                                
      Parasite Metazoan                                1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Diffuse                        1 (100%)                                                        
   Intestine Large, Colon                             (50)         (1)          (48)                                                
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  1 (2%)                                                                       
      Parasite Metazoan                                1 (2%)                                                                       
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Diffuse                        1 (100%)                                                        
   Intestine Small, Duodenum                          (47)         (2)          (42)                                                
      Hyperplasia, Atypical, Focal                                  1 (50%)                                                         
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Diffuse                        1 (50%)                                                         
   Intestine Small, Ileum                             (44)         (1)          (41)                                                
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
   Intestine Small, Jejunum                           (47)         (2)          (42)                                                
      Diverticulum                                                  1 (50%)      1 (2%)                                             
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Serosa, Inflammation, Chronic, Diffuse                        1 (50%)                                                         
   Liver                                              (50)         (5)          (50)                                                
      Erythrophagocytosis, Diffuse                                               3 (6%)                                             
      Fatty Change, Diffuse                                                      2 (4%)                                             
      Hematopoietic Cell Proliferation, Diffuse                     1 (20%)                                                         
      Hematopoietic Cell Proliferation, Multifocal     2 (4%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 13 (26%)                   9 (18%)                                            
      Inflammation, Focal, Subacute                                              1 (2%)                                             
      Necrosis, Acute, Focal                           1 (2%)                    1 (2%)                                             
      Necrosis, Focal, Subacute                        1 (2%)                                                                       
      Pigmentation, Diffuse, Hemosiderin                                         2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Centrilobular, Fatty Change                      2 (4%)                    1 (2%)                                             
      Periportal, Fatty Change                         1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Focal                          1 (20%)                                                         
      Serosa, Inflammation, Subacute                   1 (2%)                                                                       
   Mesentery                                          (1)          (1)          (2)                                                 
      Cyst                                                          1 (100%)                                                        
      Fat, Necrosis                                    1 (100%)     1 (100%)                                                        
   Pancreas                                           (48)                      (48)                                                
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Cyst                                             2 (4%)                                                                       
      Hyperplasia, Focal, Glandular                    2 (4%)                                                                       
      Hyperplasia, Glandular, Multifocal                                         1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)                                                                       
   Salivary Glands                                    (48)                      (47)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         4 (8%)                    1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 13 (27%)                  22 (47%)                                            
      Infiltration Cellular, Multifocal, Plasma                                                                                     
          Cell                                         1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (3)          (46)                                                
      Hyperplasia, Focal, Squamous                     1 (2%)       1 (33%)      5 (11%)                                            
      Hyperplasia, Multifocal                          1 (2%)                                                                       
      Hyperplasia, Multifocal, Squamous                2 (4%)       1 (33%)      1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Subacute                                                     1 (2%)                                             
      Ulcer, Acute, Multifocal                                                   2 (4%)                                             
   Stomach, Glandular                                 (50)                      (46)                                                
      Cyst                                             1 (2%)                                                                       
      Erosion, Focal                                                             2 (4%)                                             
      Erosion, Multifocal                              1 (2%)                                                                       
      Ulcer, Acute, Focal                                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Tooth                                              (1)                       (1)                                                 
      Inflammation, Chronic                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)          (49)                                                
      Coronary Artery, Hyperplasia, Chronic,                                                                                        
          Multifocal                                   1 (2%)                                                                       
      Epicardium, Inflammation, Diffuse, Subacute                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)                      (49)                                                
      Congestion, Focal                                1 (2%)                                                                       
      Hypertrophy, Focal                                                         1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Vacuolization Cytoplasmic, Multifocal            2 (4%)                                                                       
      Spindle Cell, Hyperplasia                        1 (2%)                                                                       
   Parathyroid Gland                                  (24)                      (20)                                                
      Cyst                                                                       1 (5%)                                             
      Infiltration Cellular, Focal, Plasma Cell        1 (4%)                                                                       
   Pituitary Gland                                    (48)         (7)          (50)                                                
      Pars Distalis, Congestion, Diffuse                            1 (14%)                                                         
      Pars Distalis, Ectasia, Focal                    1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                9 (19%)      1 (14%)     10 (20%)                                            
      Pars Distalis, Hyperplasia, Multifocal           1 (2%)                    2 (4%)                                             
   Thyroid Gland                                      (49)                      (49)                                                
      Depletion Secretory                              1 (2%)                    1 (2%)                                             
      Follicular Cell, Hyperplasia                     5 (10%)                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (11)         (49)                                                
      Abscess                                          2 (4%)                                                                       
      Angiectasis, Focal                                                         1 (2%)                                             
      Cyst                                             3 (6%)       8 (73%)      7 (14%)                                            
      Cyst Multilocular                                6 (12%)      4 (36%)      4 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                       3 (6%)                                                                       
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  2 (4%)                    3 (6%)                                             
   Uterus                                             (50)         (36)         (50)                                                
      Abscess                                          1 (2%)                                                                       
      Amyloid Deposition, Diffuse                                                1 (2%)                                             
      Dilatation                                       2 (4%)                    1 (2%)                                             
      Hemorrhage, Chronic                                           1 (3%)       1 (2%)                                             
      Hyperplasia, Chronic, Cystic, Diffuse           41 (82%)     35 (97%)     41 (82%)                                            
      Hyperplasia, Diffuse, Lymphoid                   1 (2%)                                                                       
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Diffuse                        1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                      (50)                                                
      Myelofibrosis                                    2 (4%)                                                                       
      Pigmentation, Diffuse, Hemosiderin                                         2 (4%)                                             
   Lymph Node                                         (50)         (7)          (50)                                                
      Axillary, Infiltration Cellular, Diffuse,                                                                                     
           Plasma Cell                                 1 (2%)                                                                       
      Iliac, Hematopoietic Cell Proliferation,                                                                                      
           Diffuse                                     1 (2%)                                                                       
      Iliac, Hyperplasia, Diffuse, Lymphoid            2 (4%)                                                                       
      Mediastinal, Infiltration Cellular, Diffuse,                                                                                  
           Plasma Cell                                 1 (2%)                                                                       
      Renal, Hyperplasia, Diffuse, Lymphoid            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (47)         (6)          (48)                                                
      Giant Cell, Diffuse                              1 (2%)                                                                       
      Hematopoietic Cell Proliferation, Diffuse                                  1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
      Infiltration Cellular, Diffuse, Histiocyte       1 (2%)                                                                       
   Spleen                                             (50)         (12)         (49)                                                
      Congestion, Diffuse                                                        2 (4%)                                             
      Erythrophagocytosis, Diffuse                                               3 (6%)                                             
      Hematopoietic Cell Proliferation, Diffuse        5 (10%)      2 (17%)      7 (14%)                                            
      Hyperplasia, Diffuse, Lymphoid                   1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                    3 (6%)                                             
      Capsule, Inflammation, Acute                     1 (2%)                                                                       
   Thymus                                             (43)         (1)          (39)                                                
      Atrophy, Diffuse                                                           3 (8%)                                             
      Medulla, Hyperplasia, Focal, Lymphoid            6 (14%)                   4 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (1)          (48)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
   Skin                                               (49)         (6)          (50)                                                
      Inflammation, Chronic                            1 (2%)       3 (50%)      7 (14%)                                            
      Subcutaneous Tissue, Necrosis                                 1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                      (50)                                                
      Hyperostosis                                     2 (4%)                                                                       
      Osteoporosis                                     1 (2%)                    1 (2%)                                             
   Skeletal Muscle                                                 (1)                                                              
      Hemorrhage, Acute                                             1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)                      (50)                                                
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  1 (2%)                                                                       
      Mineralization, Multifocal                      21 (43%)                  19 (38%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (7)          (49)                                                
      Abscess                                                       1 (14%)                                                         
      Atelectasis, Diffuse                                          1 (14%)                                                         
      Congestion, Diffuse                              1 (2%)       2 (29%)      3 (6%)                                             
      Foreign Body                                                  1 (14%)                                                         
      Hyperplasia, Focal, Adenomatous                  1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Diffuse, Histiocyte       1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 35 (70%)                  35 (71%)                                            
      Alveolus, Infiltration Cellular, Histiocyte                   1 (14%)                                                         
      Bronchiole, Inflammation, Acute                               1 (14%)                                                         
      Mediastinum, Bacterium                           1 (2%)                                                                       
      Mediastinum, Inflammation, Chronic,                                                                                           
          Multifocal                                   1 (2%)                                                                       
   Nose                                               (50)                      (50)                                                
      Foreign Body                                     2 (4%)                    1 (2%)                                             
      Inflammation, Acute                              3 (6%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      112MG/KG     225MG/KG                                               
                                                   F             FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)                                                 
      Degeneration, Chronic, Diffuse                   1 (50%)                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (3)          (50)                                                
      Casts                                                                      3 (6%)                                             
      Cyst                                                                       2 (4%)                                             
      Hydronephrosis                                                             3 (6%)                                             
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 34 (68%)                  32 (64%)                                            
      Nephropathy, Diffuse                                          1 (33%)      3 (6%)                                             
      Glomerulus, Amyloid Deposition, Diffuse          1 (2%)                    1 (2%)                                             
      Papilla, Mineralization, Multifocal                                        1 (2%)                                             
   Urinary Bladder                                    (48)                      (45)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell                                    1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                  6 (13%)                   5 (11%)                                            
      Inflammation, Diffuse, Subacute                                            1 (2%)                                             
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           6            4            3                                                  
    Dead                                               6            3           12                                                  
    Accident                                           1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           43           34                                                  
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)                      (49)                                                
      Serosa, Inflammation, Subacute                                             1 (2%)                                             
   Gallbladder                                        (41)                      (39)                                                
      Cyst                                                                       1 (3%)                                             
   Intestine Large, Cecum                             (49)                      (45)                                                
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Large, Colon                             (48)                      (47)                                                
      Parasite Metazoan                                2 (4%)                                                                       
   Intestine Large, Rectum                            (47)                      (49)                                                
      Inflammation, Acute, Focal                                                 1 (2%)                                             
   Intestine Small                                    (50)         (5)          (50)                                                
      Diverticulum                                                  1 (20%)                                                         
   Intestine Small, Duodenum                          (47)         (2)          (43)                                                
      Amyloid Deposition, Chronic, Diffuse                                       1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (4)          (43)                                                
      Diverticulum                                     1 (2%)       3 (75%)                                                         
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
   Liver                                              (50)         (16)         (50)                                                
      Basophilic Focus                                 3 (6%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                                                                       
      Inclusion Body Intranuclear, Diffuse             1 (2%)                                                                       
      Infarct                                          1 (2%)       1 (6%)                                                          
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                                                   1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Karyomegaly, Diffuse                             1 (2%)                                                                       
      Mixed Cell Focus                                              1 (6%)       2 (4%)                                             
      Necrosis, Acute, Focal                           2 (4%)                                                                       
      Necrosis, Acute, Multifocal                                                1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Fatty Change                      2 (4%)                    2 (4%)                                             
      Centrilobular, Necrosis, Acute, Diffuse                                    1 (2%)                                             
   Pancreas                                           (50)                      (48)                                                
      Atrophy, Focal                                   1 (2%)                                                                       
      Edema, Acute, Diffuse                                                      1 (2%)                                             
      Hyperplasia, Focal, Glandular                                              1 (2%)                                             
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
   Salivary Glands                                    (50)                      (50)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         2 (4%)                    1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 17 (34%)                  16 (32%)                                            
   Stomach, Forestomach                               (49)                      (46)                                                
      Cyst                                             1 (2%)                                                                       
      Cyst Epithelial Inclusion                                                  2 (4%)                                             
      Diverticulum, Focal                              1 (2%)                                                                       
      Hyperplasia, Focal, Squamous                     2 (4%)                    2 (4%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                    2 (4%)                                             
   Stomach, Glandular                                 (47)                      (47)                                                
      Cyst, Focal                                      1 (2%)                                                                       
      Cyst Epithelial Inclusion, Focal                 1 (2%)                                                                       
      Degeneration, Cystic, Focal                      1 (2%)                                                                       
      Edema, Diffuse                                                             1 (2%)                                             
      Erosion, Focal                                   1 (2%)                                                                       
      Hyperplasia, Focal                                                         1 (2%)                                             
      Hyperplasia, Adenomatous                                                   1 (2%)                                             
   Tooth                                              (6)                       (1)                                                 
      Inflammation, Chronic                            6 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)          (50)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                                                   1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Atrium, Thrombosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (1)          (49)                                                
      Cytoplasmic Alteration, Focal                                              1 (2%)                                             
      Hyperplasia, Focal                               3 (6%)                    1 (2%)                                             
      Hypertrophy, Focal                               5 (10%)                   8 (16%)                                            
      Hypertrophy, Multifocal                          1 (2%)                                                                       
      Spindle Cell, Hyperplasia, Focal                 1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Gland, Medulla                             (47)                      (49)                                                
      Hyperplasia, Multifocal                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (1)          (47)                                                
      Hyperplasia, Focal                               3 (6%)                                                                       
   Parathyroid Gland                                  (20)                      (31)                                                
      Cyst                                                                       1 (3%)                                             
   Pituitary Gland                                    (45)                      (50)                                                
      Pars Distalis, Cyst                              2 (4%)                    3 (6%)                                             
   Thyroid Gland                                      (49)                      (50)                                                
      Cyst                                             1 (2%)                                                                       
      Depletion Secretory                                                        1 (2%)                                             
      Hemorrhage, Acute, Focal                                                   1 (2%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
      C-Cell, Hyperplasia, Chronic, Focal                                        1 (2%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)                      (50)                                                
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
   Penis                                              (1)                       (1)                                                 
      Congestion                                       1 (100%)                  1 (100%)                                           
      Inflammation, Chronic                            1 (100%)                                                                     
   Preputial Gland                                    (2)          (3)          (2)                                                 
      Abscess                                          1 (50%)      3 (100%)     1 (50%)                                            
      Inflammation, Chronic                            1 (50%)                   1 (50%)                                            
   Prostate                                           (49)                      (48)                                                
      Dilatation                                                                 1 (2%)                                             
   Seminal Vesicle                                                              (2)                                                 
      Dilatation                                                                 2 (100%)                                           
      Inflammation, Chronic, Diffuse                                             1 (50%)                                            
   Testes                                             (50)         (1)          (50)                                                
      Atrophy, Diffuse                                 1 (2%)       1 (100%)     1 (2%)                                             
      Degeneration, Diffuse                                                      1 (2%)                                             
      Granuloma Sperm, Focal                           1 (2%)                                                                       
      Mineralization, Focal                            2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (49)         (8)          (50)                                                
      Congestion                                                    1 (13%)                                                         
      Hematopoietic Cell Proliferation, Diffuse                                  1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Pigmentation                                                  1 (13%)                                                         
      Thrombosis                                                                 1 (2%)                                             
      Thoracic, Angiectasis                                         1 (13%)                                                         
   Lymph Node, Mesenteric                             (48)         (5)          (50)                                                
      Congestion, Diffuse                              5 (10%)                                                                      
      Ectasia, Diffuse                                                           3 (6%)                                             
      Giant Cell, Diffuse                              6 (13%)                   2 (4%)                                             
      Hematopoietic Cell Proliferation, Diffuse        2 (4%)                                                                       
      Hemorrhage, Diffuse                              2 (4%)                                                                       
      Hyperplasia, Diffuse, Re Cell                                              1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
   Spleen                                             (49)         (4)          (50)                                                
      Hematopoietic Cell Proliferation, Diffuse       10 (20%)      3 (75%)      4 (8%)                                             
      Hyperplasia, Lymphoid                                                      4 (8%)                                             
   Thymus                                             (24)                      (35)                                                
      Atrophy, Diffuse                                                           2 (6%)                                             
      Cyst                                             2 (8%)                    1 (3%)                                             
      Mediastinum, Inflammation, Acute                                           1 (3%)                                             
      Medulla, Hyperplasia, Focal, Lymphoid                                      1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (9)          (49)                                                
      Abscess                                          1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Edema, Acute, Diffuse                                                      1 (2%)                                             
      Inflammation, Chronic                            6 (12%)      3 (33%)      4 (8%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
      Hair Follicle, Atrophy, Focal                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                      (50)                                                
      Cartilage, Proliferation, Chronic, Focal                                   1 (2%)                                             
      Coccygeal, Hyperostosis                          1 (2%)                                                                       
      Cranium, Inflammation, Chronic                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                      (50)                                                
      Demyelination, Multifocal                        1 (2%)                                                                       
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hydrocephalus                                                              1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Mineralization, Multifocal                      24 (48%)                  24 (48%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (7)          (50)                                                
      Congestion, Diffuse                              2 (4%)                    5 (10%)                                            
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hemorrhage, Multifocal                                                     1 (2%)                                             
      Hyperplasia, Focal, Adenomatous                  4 (8%)       1 (14%)      1 (2%)                                             
      Infiltration Cellular, Diffuse, Histiocyte       1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                 25 (50%)                  26 (52%)                                            
      Infiltration Cellular, Multifocal, Histiocyte                              1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Pleura, Inflammation, Subacute                                             1 (2%)                                             
   Nose                                               (50)                      (50)                                                
      Foreign Body                                     8 (16%)                   1 (2%)                                             
      Hyperplasia, Focal, Glandular                                              1 (2%)                                             
      Inflammation, Acute                              6 (12%)                   3 (6%)                                             
      Inflammation, Chronic                            2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (3)          (50)                                                
      Cyst                                             2 (4%)                    5 (10%)                                            
      Ectopic Tissue                                                             1 (2%)                                             
      Hyperplasia, Focal, Tubular                      1 (2%)                    1 (2%)                                             
      Hyperplasia, Multifocal, Tubular                                           1 (2%)                                             
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                         1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell,                                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05704-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:00:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      112MG/KG     225MG/KG                                               
                                                   M             MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
           Multifocal                                 39 (78%)                  36 (72%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Nephropathy, Diffuse                             1 (2%)                    3 (6%)                                             
      Vacuolization Cytoplasmic, Multifocal                                      1 (2%)                                             
      Cortex, Degeneration, Diffuse, Hyaline           1 (2%)                    1 (2%)                                             
      Cortex, Vacuolization Cytoplasmic, Multifocal                              1 (2%)                                             
      Glomerulus, Amyloid Deposition, Diffuse                                    1 (2%)                                             
      Glomerulus, Inflammation, Diffuse, Subacute,                                                                                  
           Suppurative                                 1 (2%)                                                                       
      Proximal Convoluted Renal Tubule,                                                                                             
          Degeneration, Focal                                                    1 (2%)                                             
      Proximal Convoluted Renal Tubule, Dilatation,                                                                                 
           Diffuse                                                  1 (33%)                                                         
   Urinary Bladder                                    (49)                      (48)                                                
      Concretion                                       6 (12%)                   2 (4%)                                             
      Edema, Acute, Diffuse                                                      1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Inflammation, Acute, Diffuse                     1 (2%)                                                                       
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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