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TDMS Study 05706-01 Pathology Tables

NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97
Route: DOSED FEED                                                                                                 Time: 07:52:59




       Facility:  International Research and Development Corp.

       Chemical CAS #:  81-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|             
                                           | 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +  +  M  +  +  +  +     +  +  +  M  +  +  +        +  +  +   |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +     +  +  +  M  +  +  +     +  +  +  +  +  A  +        +  A  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  A  +   |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     +  M  +  +  +  +  +     +  +  +  M  +  M  +        +  +  +   |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  +  +   |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  +  +   |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Hepatocellular Carcinoma             |                                              X                           |             
      Hepatocellular Adenoma               |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Lymphoma Malignant Mixed             |                                           X        X  X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                      X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|             
                                           | 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  M  +   |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  M  +   |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     M  +  +  +  M  M  +     +  +  +  +  +  M  +        +  +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Pars Distalis, Adenoma               |                X                                                         |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X        X                                                         |             
      Lymphoma Malignant Mixed             |             X                                      X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|             
                                           | 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Endometrium, Polyp Stromal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  A  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |             X                                                            |             
      Iliac, Lymphoma Malignant Histiocytic|                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |             X                                                            |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |       X        X                                                         |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |       X                                                                  |             
      Mandibular, Lymphoma Malignant Mixed |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |       X                                X                                 |             
      Mediastinal, Lymphoma Malignant Mixed|                                                    X                     |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|       X                                                                  |             
      Renal, Lymphoma Malignant Mixed      |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  A  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Lymphoma Malignant Mixed             |             X                             X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|             
                                           | 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                      X                           |             
      Lymphoma Malignant Mixed             |             X                             X        X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     M     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                X                             X                           |             
      Lymphoma Malignant Mixed             |                                           X        X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +     +  +  +  +  +  +  M     +  +  +  +  +  +  +        +  +  M   |             
      Adenocarcinoma                       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Oligodendroglioma Benign             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +     +  +  +  M  +  +  +     +  +  +  +  M     +        M     M   |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                               X           X                              |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                      X   |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X        X                                                         |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |       X        X                                                         |             
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|             
                                           | 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                    X  X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                          |             
      Renal Tubule, Carcinoma, Metastatic, |                                                                          |             
           Kidney                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Lymphocytic       |       X        X                                                         |             
      Lymphoma Malignant Mixed             |             X                                      X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |       X        X                       X     X                           |             
      Lymphoma Malignant Mixed             |             X                             X        X  X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|             
                                           | 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  M  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                          X               |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                X                                                         |             
      Hepatocellular Adenoma               |                                  X              X        X               |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                          +                       +              +   |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|             
                                           | 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Papilloma              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     +  M  +  M  +  +  +  +  M     +  M  +     +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X                    X  X                       X                  |             
      Pars Distalis, Carcinoma             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|             
                                           | 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Endometrium, Polyp Stromal           |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Histiocytic|                                                                      X   |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                      X                                                   |             
      Inguinal, Lymphoma Malignant Mixed   |                               X                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                      X                                   X               |             
      Mandibular, Lymphoma Malignant Mixed |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                      X                                                   |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                      X                                                   |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  M  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                      X                                   X     X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Skin    |       X                                                                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|             
                                           | 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                   X     X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     M  M  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                      X           X                                       |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  M     +  +  +  +  +  M  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Oligodendroglioma Benign             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +     +  +  +  M  +  +  +  M  +     +  +  M     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X           X           X        X                                    |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                  X                                       |             
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                  X                       X               |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|             
                                           | 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
      Renal Tubule, Carcinoma              |                                                                          |             
      Renal Tubule, Carcinoma, Metastatic, |                                                                          |             
           Kidney                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                      X           X                       X     X         |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +  +                                             |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     +  +  +  +  +  M                                             |  45        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +                                             |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +                                             |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  A  +  +  +  +                                             |  47        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  A  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +                                             |  49        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Adenoma               |                                                                          |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |             X           X                                                |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +                                             |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +                                             |  49        |
      Pheochromocytoma Benign              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M     +  +  M  +  M  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Adenoma               |                      X  X                                                |          7 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |             X                                                            |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +                                             |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |             X           X                                                |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Iliac, Lymphoma Malignant Histiocytic|                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                         X                                                |          2 |
      Iliac, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                X                                                         |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          3 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          3 |
      Mandibular, Lymphoma Malignant Mixed |             X           X                                                |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Lymphoma Malignant Mixed|             X           X                                                |          3 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                X                                                         |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                         X                                                |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +                                             |  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          4 |
      Lymphoma Malignant Mixed             |             X           X                                                |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          5 |
      Lymphoma Malignant Mixed             |             X           X                                                |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +  +  M  +  +  +                                             |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          4 |
      Lymphoma Malignant Mixed             |             X                                                            |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +  +  +  M  +                                             |  45        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Oligodendroglioma Benign             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +     +        +  +  +                                             |  36        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |    X  X     X              X                                             |         10 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          2 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Mediastinum, Lymphoma Malignant Mixed|             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X                                                |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          2 |
      Renal Tubule, Carcinoma              |                   X                                                      |          1 |
      Renal Tubule, Carcinoma, Metastatic, |                                                                          |            |
           Kidney                          |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  M  +  +  +  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                         X                                                |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          8 |
      Lymphoma Malignant Mixed             |             X           X                                                |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 5| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 2|             
                                           | 9| 1| 2| 2| 2| 6| 2| 6| 9| 1| 0| 2| 1| 2| 9| 1| 9| 0| 0| 1| 9| 9| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                         +                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +     +        +  +  +  +  +     +           +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +     +        +  +  +  +  +     +           +        +      |             
                                            __________________________________________________________________________|             
   Liver                                   |          +                 +        +  +                 +  +        +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                            X                                         X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                     +              +                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                         +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                    +                     |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                     +                                    |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 5| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 2|             
                                           | 9| 1| 2| 2| 2| 6| 2| 6| 9| 1| 0| 2| 1| 2| 9| 1| 9| 0| 0| 1| 9| 9| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                               +     +           +  +        +           +|             
      Cystadenoma                          |                               X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +     +              +  +           +                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Iliac, Lymphoma Malignant Lymphocytic|          X                                                               |             
      Iliac, Lymphoma Malignant Mixed      |                                     X                                    |             
      Inguinal, Lymphoma Malignant Mixed   |                                     X                                    |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |          X                                                               |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |          X                                                               |             
      Mediastinal, Lymphoma Malignant Mixed|                                     X                                    |             
      Renal, Lymphoma Malignant Lymphocytic|          X                                                               |             
      Renal, Lymphoma Malignant Mixed      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +           +  +        +  +  +  +           +        +  +   |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                            X        X                                X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                     +                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +              +  +  +  +  +        +  +  +  +  +     +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 5| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 2|             
                                           | 9| 1| 2| 2| 2| 6| 2| 6| 9| 1| 0| 2| 1| 2| 9| 1| 9| 0| 0| 1| 9| 9| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
      Mucosa, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +     +     +  +        +  +                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                            X        X                                X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 2| 5| 3| 2| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 6| 5| 3|             
                                           | 6| 1| 9| 6| 0| 9| 9| 1| 1| 8| 0| 1| 0| 1| 0| 8| 2| 9| 0| 0| 6| 6| 2| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                    +     +                 +     +              +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +                    +     +                 A                    A      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                    A     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A                    A     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                    A     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +                    A     M                 A     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +                 A  +  +     +  +  +  +  A  +  +     +        A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A                    A     +                 A     +              A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A                    A     +                 A     +              A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +                 A  +  +     +  +  +  +  A  +  +     +        A     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +                    +  +  +     +           +     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                  X                                X      |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                    A     +                 A     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                    +     +                 +     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +                    +     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +                    +     +                 A     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +                    +     +                 A     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                    +     +                 +     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +                    +     +                 +     +              +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +                    +     +                 A     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +                    +     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                    A     +                 A     +              +      |             
      Adenoma                              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M                    M     M                 M     M              M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | A                    +     +  +           +  +     +              +      |             
      Pars Distalis, Adenoma               |                               X           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                    +     +  +              A     +              +      |             
      Follicular Cell, Adenoma             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 2| 5| 3| 2| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 6| 5| 3|             
                                           | 6| 1| 9| 6| 0| 9| 9| 1| 1| 8| 0| 1| 0| 1| 0| 8| 2| 9| 0| 0| 6| 6| 2| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +                 +  +     +                 A  +  +  +           +      |             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +     +  +  +  +     +  +  +     A  +  +  +  +        +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +                    +     +                 +     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +        +     +  +  +           A     +     +        +      |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                   X      |             
      Iliac, Lymphoma Malignant Mixed      |                      X                                                   |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                  X                                       |             
      Mediastinal, Lymphoma Malignant Mixed|                      X                                                   |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                   X      |             
      Renal, Lymphoma Malignant Mixed      |                      X        X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +                    +     M                 A     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +           +  +  +  +  +  +        +  A  +  +              +     +|             
      Hemangiosarcoma                      |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                      X        X                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +              +     +                 M     +              +      |             
      Lymphoma Malignant Lymphocytic       |       X                                                           X      |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                    +     +                 M     +              +      |             
                                            __________________________________________________________________________|             
   Skin                                    | M           +        +     +           +  +  +     +     +        +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 2| 5| 3| 2| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 6| 5| 3|             
                                           | 6| 1| 9| 6| 0| 9| 9| 1| 1| 8| 0| 1| 0| 1| 0| 8| 2| 9| 0| 0| 6| 6| 2| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +                    +     +                 +     +              +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                    +     +                 +     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +     +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +                    +     +                 +     +              +      |             
      Mucosa, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                    +     +                 +     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
      Adenoma                              |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +                 +                       A     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A                    +     +                 +     +              +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                          X                                X      |             
      Lymphoma Malignant Mixed             |                      X        X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 7| 4| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3|                                            |            |
                                           | 3| 6| 0| 6| 6| 6| 9| 2| 1| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M                                                                        |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M                                                                        |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                                                                        |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A                                                                        |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A                                                                        |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |   4        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A     +              +  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A     +              +  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Liver                                   | A                    +     +                                             |  17        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | A                                                                        |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | M                                                                        |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                                                                        |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | M                                                                        |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                                                                        |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                                                                        |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                                                                        |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A                                                                        |   5        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M                                                                        |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 7| 4| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3|                                            |            |
                                           | 3| 6| 0| 6| 6| 6| 9| 2| 1| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M                                                                        |   7        |
      Pars Distalis, Adenoma               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M                                                                        |   7        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  15        |
      Cystadenoma                          |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +           +  +  +  +                                             |  45        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M                 +                                                      |  17        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |          2 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          2 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M                                                                        |   5        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | M                    +  +  +                                             |  29        |
      Hemangiosarcoma                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 7| 4| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3|                                            |            |
                                           | 3| 6| 0| 6| 6| 6| 9| 2| 1| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                                                        |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +              +                                                   |  27        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |   7        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | M                                                                        |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | M     +           +  +  +  +                                             |  49        |
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | M                                                                        |   6        |
      Mucosa, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | M                                                                        |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                    +  +                                                |  14        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 7| 4| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3|                                            |            |
                                           | 3| 6| 0| 6| 6| 6| 9| 2| 1| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +           +  +  +  +                                             |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|             
                                           | 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +     +  +  +  +  M        +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +  +  +  +     +  +  A  +  A        +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +     +  +  A  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +     +  +  A  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +     +  +  A  +  A        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +     +  +  A  +  A        +  +  +  +  +  M     +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +     +  +  A  +  A        +  +  +  +  +  +     +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +     +  +  A  +  M        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Hepatocellular Adenoma               |                               X                                          |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                          X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                          X                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                          X                 X            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                          X                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|             
                                           | 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                X                          X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     M  +  +  +  +  +  +     M  M  M  +  M        +  +  M  M  +  M     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  M  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Pars Distalis, Adenoma               |       X              X                 X                                 |             
      Pars Distalis, Carcinoma             |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  M  +  +     +|             
      Follicular Cell, Carcinoma           |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                          X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Hemangioma                           |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Mixed Tumor Malignant                |                                                                          |             
      Endometrium, Polyp Stromal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  +     +  +  M  +  +        +  +  +  +  M  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |                X                                                         |             
      Bronchial, Lymphoma Malignant Mixed  |                                           X                              |             
      Iliac, Lymphoma Malignant Histiocytic|                                                                          |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|             
                                           | 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                X                                                         |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                                           X                              |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                X                                                         |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                           X                              |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +     +  +  M  +  +        +  +  +  +  M  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                X                          X                 X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                          X                 X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                         X                                X               |             
      Lymphoma Malignant Mixed             |                X                          X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +  +  +  +     +  +  +  M  M        +  +  +  +  +  +     +|             
      Adenocarcinoma                       |                                  X                                       |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|             
                                           | 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Lymphoma Malignant Mixed             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +        +  +     +  +  +     +        +  +        +     +     +  +     +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                               X           X                              |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                X                          X                 X            |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
      Adenoma                              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                X                          X                 X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|             
                                           | 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
      Lymphoma Malignant Mixed             |                X                          X                 X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                         X                                X               |             
      Lymphoma Malignant Mixed             |                X                          X                 X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|             
                                           | 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    12500PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +     +  +  +  +  +  +  M  +     +        +  +  +  +  A  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +     +  +  +  +  +  A  +  +     +        +  +  +  +  A  A|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +     +  +  M  +  +  +  +  M     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +     +  +  +  +  +  A  +  +     +        +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +     +  M  +  +  +  A  A  M     +        +  +  +  +  A  A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  A  A|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +     +  +  +  +  +  M  A  +     +        +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                X         |             
      Leukemia                             |                                     X                                    |             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|             
                                           | 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    12500PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     M  M     +  +  +  +  M  M  +  +     +        +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                X         |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  M|             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Cystadenoma                          |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mixed Tumor Malignant                |                                                                          |             
      Endometrium, Polyp Stromal           |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                                 |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                             X            |             
      Axillary, Lymphoma Malignant Mixed   |                                        X                                 |             
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |             
      Iliac, Lymphoma Malignant Histiocytic|    X                                                                     |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                             X            |             
      Iliac, Lymphoma Malignant Mixed      |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|             
                                           | 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    12500PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                             X            |             
      Inguinal, Lymphoma Malignant Mixed   |                                        X                                 |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |    X                                                                     |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                             X            |             
      Mandibular, Lymphoma Malignant Mixed |                                        X                                 |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
      Renal, Lymphoma Malignant Histiocytic|    X                                                                     |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                        X                                 |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia                             |                                     X                                    |             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  A  +|             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +     +  +  +  M  +  +  +  +     M        +  +  +  +  M  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|             
                                           | 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    12500PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  M  +     +  +     +  +  +  +  +     +  +     +        +  +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                        X                                 |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                          X               |             
      Leukemia                             |                                     X                                    |             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     M  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|             
                                           | 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    12500PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Leukemia                             |                                     X                                    |             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +  +  +  +     +                                             |  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  M     +                                             |  43        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +                                             |  45        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +     +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  M     +                                             |  38        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +                                             |  44        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia                             |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +     +                                             |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +     +                                             |  47        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +                                             |  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  M     +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +                                             |  48        |
      Pars Distalis, Adenoma               |             X  X                                                         |          6 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +                                             |  46        |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Cystadenoma                          |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +     +                                             |  48        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mixed Tumor Malignant                |    X                                                                     |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +     +                                             |  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +     +                                             |  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      | X                                                                        |          2 |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          2 |
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |          1 |
      Iliac, Lymphoma Malignant Histiocytic|                                                                          |          1 |
      Iliac, Lymphoma Malignant Lymphocytic| X                                                                        |          2 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Iliac, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          2 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          2 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Lymphoma Malignant Histiocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic| X                                                                        |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +                                             |  46        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hemangiosarcoma                      |             X                                                            |          1 |
      Leukemia                             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M     +                                             |  46        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +     +                                             |  43        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   2        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +     +                                             |  39        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Alveolar/Bronchiolar Adenoma         |                            X                                             |          4 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Leukemia                             |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +     +                                             |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   2        |
      Adenoma                              |          X                                                               |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +                                             |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +     +                                             |  49        |
      Leukemia                             |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X                    X                                                   |          5 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +     +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                   X                                                      |             
      Hepatocellular Carcinoma, Multiple   |                                              X                           |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocholangiocarcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hemangioma                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     +  M  M  M  M  +     +  +  +  +  +  +  +  +  +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                            +        +     +  +         |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                         X                                                |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     M  M|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Sarcoma                              |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +     +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +     +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M     M  M  M  M  M  M     M  M  +  M  M  M  M  M  M  M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Subcutaneous Tissue, Fibroma         |                X     X                                                   |             
      Subcutaneous Tissue, Fibrosarcoma    |                                              X        X                  |             
      Subcutaneous Tissue, Sarcoma         |                                                 X                        |             
      Sweat Gland, Adenocarcinoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +           +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                X  X                                                      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                    X                    X|             
      Alveolar/Bronchiolar Carcinoma       |                                                       X                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
      Adenoma                              |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|             
                                           | 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  M     +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  M  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  A     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  A     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                                              X                           |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |                            X              X                              |             
      Hepatocholangiocarcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Hemangioma                           |    X                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  +  +  M     +  +  +  +  M  +     +  M  M     +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Follicular Cell, Adenoma             |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                            +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|             
                                           | 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  M  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  +  M  +     +  +  +  +  M  +     +  +  +     M  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M  M     M  M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
      Sweat Gland, Adenocarcinoma          |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +     +  +  +  +  +     +     +  M  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                    X                 X  X  X                        |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       | X                    X                                                   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|             
                                           | 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 4| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3|                                            |            |
                                           | 0| 2| 0| 6| 6| 2| 1| 2| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +     +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +        M  +  +     +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +        +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +        +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +        +  +  M     +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +        +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +        +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +        +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +        +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +        +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +     +                                             |  50        |
      Hemangiosarcoma                      |    X                                                                     |          1 |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Hepatocholangiocarcinoma             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +     +                                             |  49        |
      Hemangioma                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +     +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  +     +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  M     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +     +                                             |  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 4| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3|                                            |            |
                                           | 0| 2| 0| 6| 6| 2| 1| 2| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +        +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +        +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | A  +  +        +  +  +     +                                             |  48        |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +        +  +  +     +                                             |  45        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +     +                                             |  50        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  +  +     +                                             |  44        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M        M  M  M     M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +     +                                             |  50        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
      Sweat Gland, Adenocarcinoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +        +  +  +     +                                             |  41        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 4| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3|                                            |            |
                                           | 0| 2| 0| 6| 6| 2| 1| 2| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +     +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                X     X     X                                             |         10 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +     +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +        +  +  +     +                                             |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +  +     +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 0| 3| 2| 5| 2| 3| 3| 3| 1| 5| 0| 5| 5| 3| 2| 1| 3| 3| 5| 5|             
                                           | 0| 9| 1| 8| 2| 1| 1| 9| 6| 9| 0| 2| 1| 1| 6| 7| 6| 6| 0| 9| 4| 1| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Gallbladder                             |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  +     +           +  +     +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +                             +     +                           |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +  +     +           +  +     +     +                    +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +     +  +  +  +  +     +        +  +  +  +  +      |             
      Hemangiosarcoma                      |                                        X                                 |             
      Hepatocellular Carcinoma             |                                     X                                    |             
      Hepatocellular Adenoma               | X  X                 X     X        X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          M                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          M                             +     M                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          M                             +     +                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +                             +     +                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 0| 3| 2| 5| 2| 3| 3| 3| 1| 5| 0| 5| 5| 3| 2| 1| 3| 3| 5| 5|             
                                           | 0| 9| 1| 8| 2| 1| 1| 9| 6| 9| 0| 2| 1| 1| 6| 7| 6| 6| 0| 9| 4| 1| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +        +                                                  +         |             
                                            __________________________________________________________________________|             
   Prostate                                |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          M                       +  +  +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |          +                       +     +     +                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +                          +     +                           |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |          X                                                               |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|          X                                                               |             
      Pancreatic, Lymphoma Malignant Mixed |          X                                                               |             
      Prefemoral, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +                 +  +  +  +     +              +  +  +      |             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic, Liver   |                                        X                                 |             
      Lymphoma Malignant Histiocytic       |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +                             +     M                           |             
      Lymphoma Malignant Mixed             |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M                             +     M                           |             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +     +  +     +  +        +     +        +  +               |             
      Carcinoma                            |                   X                                                      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                      X                                                   |             
      Subcutaneous Tissue, Fibrosarcoma    |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 0| 3| 2| 5| 2| 3| 3| 3| 1| 5| 0| 5| 5| 3| 2| 1| 3| 3| 5| 5|             
                                           | 0| 9| 1| 8| 2| 1| 1| 9| 6| 9| 0| 2| 1| 1| 6| 7| 6| 6| 0| 9| 4| 1| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
      Fibrosarcoma, Metastatic             |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +  +     +  +  +     +        +     +     +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +     +  +  +  +  +     +        +  +  +  +  +      |             
      Alveolar/Bronchiolar Adenoma         | X                          X                                             |             
      Alveolar/Bronchiolar Carcinoma       |                                  X                                       |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    |          +                             +     +                           |             
      Mucosa, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +                             +     +                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +                       +     +     +                 +         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +                             +     +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +      |             
      Lymphoma Malignant Histiocytic       |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                  X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 2| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 2| 7| 3| 9| 3| 3| 5| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 9| 6| 0| 0| 9| 9| 0| 6| 2| 1| 6| 6| 0| 0| 9| 2| 0| 5| 2| 0| 1| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6250PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                   A     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                   +     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                   A     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                   +     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                   +     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +        +     +                             A     +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                   A     +                             A                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +        A     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                 A     +                             A     +        +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                               X        X                                 |             
      Hepatocellular Adenoma               |                                              X                 X         |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                   +     +                             +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                   +     +                             +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                   +     +                             +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                   +     +                             +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                   +     +                             +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                   +     +                             +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +     +                             +                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 2| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 2| 7| 3| 9| 3| 3| 5| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 9| 6| 0| 0| 9| 9| 0| 6| 2| 1| 6| 6| 0| 0| 9| 2| 0| 5| 2| 0| 1| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6250PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                   +     +                    +        +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Penis                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                                   +                        |             
                                            __________________________________________________________________________|             
   Prostate                                |                   A     +                             +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +     +                                                |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Testes                                  |                   +     +                             +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                   +     +                             +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +  +  +                       +     +                  |             
      Sarcoma, Metastatic, Skin            |                                                       X                  |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                         X                                                |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Prefemoral, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                         X                                                |             
      Renal, Lymphoma Malignant Lymphocytic|                         X                                                |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +  +  +                       +     A                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +  +  +  +  +  +           +  +  +     +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X              X                                                |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                   M     +                             M                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                   M     M                             M                  |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +     +  +  +  +                          +                  |             
      Carcinoma                            |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 2| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 2| 7| 3| 9| 3| 3| 5| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 9| 6| 0| 0| 9| 9| 0| 6| 2| 1| 6| 6| 0| 0| 9| 2| 0| 5| 2| 0| 1| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6250PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +     +                    +        +                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
      Fibrosarcoma, Metastatic             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +     +  +  +  +  +           +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                   X      |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                   +     +                             +                  |             
      Mucosa, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                         X                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 |                   +     +                             +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
      Adenoma                              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +  +     +     +              +        +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                   A     +                             +                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X              X                                                |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3|                                            |            |
                                           | 9| 1| 9| 9| 2| 9| 2| 2| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +              A                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A              A                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A              A                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A              A                                                         |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +              +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A              A           +                                             |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A              A                                                         |   4        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A              A                                                         |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A              A           +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          3 |
      Hepatocellular Adenoma               |    X        X                                                            |          9 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +              A                                                         |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +              A                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | A              A                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A              A                                                         |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A              A                                                         |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +              +                                                         |   8        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +              A                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +              A                                                         |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +              A                                                         |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +              A                                                         |   7        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3|                                            |            |
                                           | 9| 1| 9| 9| 2| 9| 2| 2| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M              A                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +              +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +              A                                                         |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +              +                                                         |   9        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +              +                                                      |   7        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +              +                                                         |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +           +  +                                                         |   9        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +              +                                                         |   9        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +              +                                                         |   8        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              A  +        +                                             |  13        |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                            X                                             |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Prefemoral, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +              A  +        +                                             |  10        |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +     +                                             |  39        |
      Hemangiosarcoma                      |       X                                                                  |          1 |
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3|                                            |            |
                                           | 9| 1| 9| 9| 2| 9| 2| 2| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +              M                                                         |   4        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M              M                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +              +                                                         |  20        |
      Carcinoma                            |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +                                                         |   9        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Fibrosarcoma, Metastatic             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +  +        +                                             |  41        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  A  +  +     +                                             |  48        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +              +                                                         |   8        |
      Mucosa, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +              A                                                         |   7        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3|                                            |            |
                                           | 9| 1| 9| 9| 2| 9| 2| 2| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        A  +                                                      |  14        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +              +                                                         |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +     +                                             |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|             
                                           | 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +        +  A  +  +  M     +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  M  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                         X|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             | X                                                                        |             
      Hepatocellular Adenoma               |             X  X                                                  X      |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +  +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|             
                                           | 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     M  M  M  +  +        +  M  M  +  +     M  +  M  M  M  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                             +  +         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +        +                       +  +  +     +|             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                                                                         X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                         X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                          X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                 X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  M  +        +  +  M  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M  M  M  M        M  M  M  M  M     M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Subcutaneous Tissue, Fibroma         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|             
                                           | 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                X                                                         |             
      Subcutaneous Tissue, Schwannoma NOS  | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +  +  +        +        +        +  +  +  +  +        +  M  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                                                            |             
      Alveolar/Bronchiolar Carcinoma       |                                                    X              X      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                         X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                 X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|             
                                           | 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +  +  +     +  +  +  +  +  +  M     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     M  +  +  +     +  +  +     +  +  M  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Hepatocellular Carcinoma             |                                                             X            |             
      Hepatocellular Adenoma               |                            X                                            X|             
      Hepatocellular Adenoma, Multiple     |                                                             X            |             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Capsule, Adenoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|             
                                           | 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     M  M  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  M  +     +  M  +     +  +  +  M  M  M  +     +  M     M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  M  +     +  M  +     +  +  +  +  +  +  +     +  +     +  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                                                       +|             
                                            __________________________________________________________________________|             
   Prostate                                | +     M  +  +  +     M  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +  +  M     +  +  +  +  +  +  +     +  +     +  +  +|             
      Axillary, Lymphoma Malignant Mixed   |                                           X                              |             
      Mandibular, Lymphoma Malignant Mixed |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     M  +  +  +     +  +  M     +  +  +  +  +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     M  M  +  +     +  +  +     +  +  +  +  +  +  +     +  +     M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M  M  +     M  M  M     M  M  M  M  M  M  M     M  M     M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|             
                                           | 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    | X        X                                                               |             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |             X                                                            |             
      Subcutaneous Tissue, Schwannoma NOS  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +        M  +  +     +  +  +     +  +  +  +  +  +  M     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X              X        X                                       |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                           +                              |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +  +  +     M  +  +  +  +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5|                                            |            |
                                           | 0| 0| 9| 1| 1| 5| 2| 1| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A                                                |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +                                                |  48        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  M  +  +  A  +  +  +                                                |  46        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +                                                |  48        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |    X                                                                     |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +                                                |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hepatocellular Carcinoma             |       X                                                                  |          3 |
      Hepatocellular Adenoma               |                                                                          |          5 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +                                                            |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5|                                            |            |
                                           | 0| 0| 9| 1| 1| 5| 2| 1| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +                                                |  50        |
      Capsule, Adenoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +                                                |  48        |
      Pheochromocytoma Benign              |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  +  M  +  +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +                                                |  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +     +                                                            |  11        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  A  +  +  +                                                |  47        |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  A  +  +  +                                                |  45        |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5|                                            |            |
                                           | 0| 0| 9| 1| 1| 5| 2| 1| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +                                                |  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M                                                |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
      Subcutaneous Tissue, Hemangioma      |          X                                                               |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          2 |
      Subcutaneous Tissue, Schwannoma NOS  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +     +  +                                                   |  39        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Alveolar/Bronchiolar Adenoma         |    X     X  X                                                            |          7 |
      Alveolar/Bronchiolar Carcinoma       |       X     X                                                            |          4 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05706-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:52:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5|                                            |            |
                                           | 0| 0| 9| 1| 1| 5| 2| 1| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +                                                |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +                                                |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
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