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TDMS Study 05706-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID


NTP Experiment-Test: 05706-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: DOSED FEED                                                                                                 Time: 22:48:38




       Facility:  International Research and Development Corp.

       Chemical CAS #:  81-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05706-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 22:48:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      6250PPM      12500PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               5            5            6                                                  
    Moribund                                           2            2            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           43           38                                                  
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    50           50           49                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (47)         (6)          (46)                                                
   Gallbladder                                        (45)         (3)          (43)                                                
   Intestine Large, Cecum                             (48)         (4)          (45)                                                
   Intestine Large, Rectum                            (46)         (4)          (47)                                                
   Intestine Small, Duodenum                          (47)         (2)          (38)                                                
   Intestine Small, Ileum                             (46)         (2)          (44)                                                
   Intestine Small, Jejunum                           (49)         (28)         (43)                                                
   Liver                                              (50)         (17)         (49)                                                
      Hepatocellular Carcinoma                         2 (4%)                                                                       
      Hepatocellular Adenoma                           3 (6%)                    2 (4%)                                             
   Mesentery                                          (5)          (1)          (1)                                                 
   Pancreas                                           (50)         (6)          (48)                                                
   Salivary Glands                                    (50)         (6)          (47)                                                
   Stomach, Forestomach                               (49)         (7)          (49)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (6)          (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (6)          (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (6)          (48)                                                
   Adrenal Gland, Medulla                             (49)         (6)          (47)                                                
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (5)          (48)                                                
      Adenoma                                                       1 (20%)                                                         
                                                             Page   2                                                               
NTP Experiment-Test: 05706-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 22:48:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      6250PPM      12500PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (50)         (7)          (48)                                                
      Pars Distalis, Adenoma                           7 (14%)      2 (29%)      6 (13%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (7)          (46)                                                
      Follicular Cell, Adenoma                                      1 (14%)                                                         
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (15)         (49)                                                
      Cystadenoma                                                   1 (7%)       1 (2%)                                             
   Uterus                                             (50)         (45)         (48)                                                
      Hemangioma                                                                 1 (2%)                                             
      Mixed Tumor Malignant                                                      1 (2%)                                             
      Endometrium, Polyp Stromal                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (7)          (48)                                                
   Lymph Node                                         (48)         (17)         (46)                                                
   Lymph Node, Mesenteric                             (48)         (5)          (46)                                                
   Spleen                                             (50)         (29)         (49)                                                
      Hemangiosarcoma                                               1 (3%)       1 (2%)                                             
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
   Thymus                                             (46)         (7)          (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (6)          (43)                                                
      Adenocarcinoma                                   1 (2%)                    1 (2%)                                             
   Skin                                               (50)         (27)         (49)                                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                     1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05706-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 22:48:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      6250PPM      12500PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (2)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (6)          (49)                                                
      Oligodendroglioma Benign                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (36)                      (39)                                                
   Lung                                               (50)         (49)         (49)                                                
      Alveolar/Bronchiolar Adenoma                    10 (20%)      3 (6%)       4 (8%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                                                                       
   Nose                                               (50)         (6)          (48)                                                
   Trachea                                            (50)         (6)          (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)          (2)                                                 
      Adenoma                                                       1 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (14)         (49)                                                
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
      Renal Tubule, Carcinoma, Metastatic, Kidney      1 (2%)                                                                       
   Urinary Bladder                                    (49)         (6)          (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(49)                                                
      Leukemia                                                                   1 (2%)                                             
      Lymphoma Malignant Histiocytic                   2 (4%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   8 (16%)      4 (8%)       5 (10%)                                            
      Lymphoma Malignant Mixed                         7 (14%)      5 (10%)      4 (8%)                                             
      Lymphoma Malignant Undifferentiated Cell         2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05706-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 22:48:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      6250PPM      12500PPM                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            34          17          24                                                   
     Total Primary Neoplasms                           53          21          37                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21           9          12                                                   
     Total Benign Neoplasms                            26           9          18                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          12          15                                                   
     Total Malignant Neoplasms                         27          12          19                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          2                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05706-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 22:48:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      6250PPM      12500PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           3            3            6                                                  
    Dead                                               4            6            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           40           42                                                  
  Missing                                                           1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (4)          (48)                                                
   Intestine Small, Duodenum                          (47)         (4)          (46)                                                
   Intestine Small, Ileum                             (48)         (5)          (48)                                                
   Intestine Small, Jejunum                           (47)         (14)         (48)                                                
   Liver                                              (50)         (49)         (50)                                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma                         2 (4%)       3 (6%)       3 (6%)                                             
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                           2 (4%)       9 (18%)      5 (10%)                                            
      Hepatocellular Adenoma, Multiple                                           1 (2%)                                             
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
   Pancreas                                           (49)         (7)          (50)                                                
      Hemangioma                                       1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (6)          (50)                                                
   Stomach, Glandular                                 (49)         (6)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (8)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (7)          (50)                                                
      Capsule, Adenoma                                                           1 (2%)                                             
   Adrenal Gland, Cortex                              (50)         (7)          (50)                                                
   Adrenal Gland, Medulla                             (50)         (6)          (48)                                                
      Pheochromocytoma Benign                                                    2 (4%)                                             
   Thyroid Gland                                      (50)         (7)          (49)                                                
                                                             Page   6                                                               
NTP Experiment-Test: 05706-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 22:48:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      6250PPM      12500PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (9)          (50)                                                
   Prostate                                           (50)         (7)          (48)                                                
   Seminal Vesicle                                    (49)         (9)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (8)          (50)                                                
   Lymph Node                                         (48)         (13)         (47)                                                
      Sarcoma, Metastatic, Skin                                     1 (8%)                                                          
   Lymph Node, Mesenteric                             (45)         (10)         (45)                                                
   Spleen                                             (50)         (39)         (50)                                                
      Hemangiosarcoma                                               1 (3%)                                                          
      Hemangiosarcoma, Metastatic, Liver                            1 (3%)                                                          
      Sarcoma                                          1 (2%)                                                                       
   Thymus                                             (44)         (4)          (45)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (20)         (50)                                                
      Carcinoma                                                     2 (10%)                                                         
      Subcutaneous Tissue, Fibroma                     2 (4%)       1 (5%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       1 (5%)       2 (4%)                                             
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (5%)       2 (4%)                                             
      Subcutaneous Tissue, Schwannoma NOS                                        1 (2%)                                             
      Sweat Gland, Adenocarcinoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (2)          (1)                                                 
      Fibrosarcoma, Metastatic                                      1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05706-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 22:48:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      6250PPM      12500PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (41)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (48)         (50)                                                
      Alveolar/Bronchiolar Adenoma                    10 (20%)      3 (6%)       7 (14%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       1 (2%)       4 (8%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)                                                          
   Nose                                               (50)         (8)          (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (1)                                                              
      Adenoma                                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (14)         (50)                                                
   Urinary Bladder                                    (48)         (7)          (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                                1 (2%)       1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   1 (2%)       3 (6%)       1 (2%)                                             
      Lymphoma Malignant Mixed                                      2 (4%)       2 (4%)                                             
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 05706-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 22:48:38  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      6250PPM      12500PPM                                               
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            23          24          25                                                   
     Total Primary Neoplasms                           34          30          36                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15          10          15                                                   
     Total Benign Neoplasms                            19          14          18                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              11          15          16                                                   
     Total Malignant Neoplasms                         15          16          17                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4                                                               
     Total Metastatic Neoplasm                          1           4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
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