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TDMS Study 05706-01 Pathology Tables

NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 13:29:12




       Facility:  International Research and Development Corp.

       Chemical CAS #:  81-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|             
                                           | 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +  +  M  +  +  +  +     +  +  +  M  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +     +  +  +  M  +  +  +     +  +  +  +  +  A  +        +  A  +   |             
      Infiltration Cellular, Lymphocyte    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  A  +   |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                 3     1                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     +  M  +  +  +  +  +     +  +  +  M  +  M  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     +  +  +  +  +  +  +     +  +  +  +  +  A  +        +  +  +   |             
      Peyer's Patch, Hyperplasia, Lymphoid |                2                          1                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Basophilic Focus, Multiple           |                                                                          |             
      Fatty Change, Diffuse                |       2                                                                  |             
      Fatty Change, Focal                  |                                                                          |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                      1  1  1  2                 1                        |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis, Focal                      |                      1                          1                 4      |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Fatty Change, Diffuse |                                                    2                     |             
      Periportal, Fatty Change, Diffuse    |                            2                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Amyloid Deposition                   |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                   4     1     1              2  2     1              1   |             
      Artery, Inflammation, Chronic        |             2                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       1           1                       3     2     1        1     3   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  M  +   |             
      Epithelium, Hyperplasia, Focal       | 2                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Mineralization, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|             
                                           | 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Arteriole, Thrombosis, Multifocal    |                                                                   3      |             
      Myocardium, Degeneration             |                                                                   2      |             
      Ventricle, Thrombosis                |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Capsule, Ectopic Tissue              |                                           2           2                  |             
      Capsule, Hyperplasia, Multifocal     | 2     2     2  4  2  4  3  3  2     2  2  2  3  3  2  3        2  2  3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Atrophy                              |                                                                          |             
      Degeneration, Fatty, Multifocal      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   3      |             
      Hyperplasia, Focal                   |                                                                   3      |             
      Hypertrophy, Focal                   |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  M  +   |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Hyperplasia, Multifocal              |                            1                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     M  +  +  +  M  M  +     +  +  +  +  +  M  +        +  +  M   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Cyst                                 |             2  1     4     1  4     2     4                              |             
      Infiltration Cellular, Lymphocyte    |                               2                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Angiectasis                          |                                              2                           |             
      Dilatation                           |                                        2                             3   |             
      Hyperplasia, Cystic                  | 3     4     2  3  2  1  2  2  2     3  2  3  1  1  2  2        4     2   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|             
                                           | 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy, Focal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  A  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                               4                                          |             
      Mandibular, Pigmentation, Hemosiderin|                   2                                                      |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  A  +   |             
      Amyloid Deposition                   |                                                                          |             
      Hyperplasia, Lymphoid                | 3              3  3           2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Hyperplasia, Lymphoid                |                   3  2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     M     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Amyloid Deposition                   |                                                                          |             
      Depletion Lymphoid                   |                                                                   3      |             
      Hyperplasia, Lymphoid                |                   3     2     3                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +     +  +  +  +  +  +  M     +  +  +  +  +  +  +        +  +  M   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Inflammation, Chronic                | 2     1     2     1     2                 1           1              1   |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Fibrous Osteodystrophy               |                                        3                             1   |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Mineralization, Multifocal           | 2     1     2  1     2     2  1     2  1           2           2     1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +     +  +  +  M  +  +  +     +  +  +  +  M     +        M     M   |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Atelectasis, Focal                   |       3                                                                  |             
      Hemorrhage, Focal                    |                                                                   1      |             
      Infiltration Cellular, Lymphocyte    |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|             
                                           | 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                     2                                    |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Hypertrophy, Multifocal      |                         3  2              1                              |             
      Artery, Thrombosis                   |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                 2                        |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                         3  2                          2                  |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      | 4                       3  2              1     2              1         |             
      Pleura, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Lumen, Foreign Body                  |       1           1        1  1                                          |             
      Mucosa, Degeneration, Hyaline        | 1     1                 2  1                 3     2           1     2   |             
      Mucosa, Inflammation, Chronic        | 1                                                                        |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |       2                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |             3                                                            |             
      Infiltration Cellular, Lymphocyte    |       1        2  1        1                 2  2     2                  |             
      Inflammation, Chronic, Multifocal    |                                                                      2   |             
      Glomerulus, Amyloid Deposition       |                               1                                          |             
      Renal Tubule, Degeneration, Focal    |                   1                    2     2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                   2        1  2        1     1  2     1        1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|             
                                           | 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid | 2                                                        2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                            1                          2                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                              2                           |             
      Granuloma                            |                                                          2               |             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Infiltration Cellular, Lymphocyte    |    1                 1        2                             1     1      |             
      Mitotic Alteration                   |                                           1                              |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                               3                                          |             
      Centrilobular, Fatty Change, Diffuse |                                                                          |             
      Periportal, Fatty Change, Diffuse    |                1                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                          +                       +              +   |             
      Amyloid Deposition                   |                               3                                          |             
      Fat, Necrosis, Focal                 |    3                                                  3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       2                                               1  3  1            |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2  2           1  1  2        1  3           1        2  1  2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                  1                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|             
                                           | 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Arteriole, Thrombosis, Multifocal    |                                                                          |             
      Myocardium, Degeneration             |                                                                          |             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Capsule, Ectopic Tissue              |                                                                          |             
      Capsule, Hyperplasia, Multifocal     | 2  2  2     1  2  3  3  2  2  3  2  2     2  2  4     2  3  2  2  3  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |                      2                                                   |             
      Degeneration, Fatty, Multifocal      |                            2                                             |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Hyperplasia, Focal                   |             1     2                                                      |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                         1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal              |                                                          1               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     +  M  +  M  +  +  +  +  M     +  M  +     +  +  +  M  +  M  +|             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                     2                                   1|             
      Pars Distalis, Hyperplasia, Focal    |                                                                2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                2         |             
      Follicular Cell, Hyperplasia, Focal  |                            1                    1              2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                   3              1  2                    3     2        2|             
      Infiltration Cellular, Lymphocyte    |                                     2        2                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Dilatation                           |                                  2  4                       4     3     2|             
      Hyperplasia, Cystic                  |    1        1  1  4  2  3  3  2  1        3  2  3     1  2  1  4  3     2|             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|             
                                           | 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy, Focal                       |                                                       2        1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Iliac, Hyperplasia, Lymphoid         |                   3                                                      |             
      Inguinal, Hyperplasia, Lymphoid      |                                     2                                    |             
      Mandibular, Hyperplasia, Lymphoid    |    4                                                                     |             
      Mandibular, Pigmentation, Hemosiderin|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  M  +  +|             
      Amyloid Deposition                   |                               4                                          |             
      Hyperplasia, Lymphoid                |                                              2                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                          2           4   |             
      Hyperplasia, Lymphoid                |                3                                      1                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     M  M  +  +  +  +  +|             
      Amyloid Deposition                   |                               4                                          |             
      Depletion Lymphoid                   |                                                                      4   |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  M     +  +  +  +  +  M  +|             
      Hyperplasia                          |       3                             1                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1     2           1  1     2  2     1           1     1  1         |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                     2                                    |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                2  2                                                  1   |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |    1  2        1  1  1  1  1     3  1     2  1  1     1     1  1  2  1  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +     +  +  +  M  +  +  +  M  +     +  +  M     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Atelectasis, Focal                   |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|             
                                           | 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    3                 2                                                   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                       2                 1|             
      Artery, Hypertrophy, Multifocal      |    3        4                                   3     4                 4|             
      Artery, Thrombosis                   |                   1                                                      |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                                          |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      | 2  2        3                       2     2     2     2                 3|             
      Pleura, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Degeneration, Hyaline        | 2  2  2     2  2     2  1     2  3  1     1     2        1     2  1      |             
      Mucosa, Inflammation, Chronic        |                                     2                                    |             
      Mucosa, Inflammation, Chronic Active |                1                                                         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |             2        1        2  2  2           1                 1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                               4                                          |             
      Hydronephrosis                       |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1           1  2  2  1     4        1                                    |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Glomerulus, Amyloid Deposition       |                                                 3                        |             
      Renal Tubule, Degeneration, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  2        1     2  1  1                                               2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     +  +  +  +  +  M                                             |  45        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +                                             |  48        |
      Peyer's Patch, Hyperplasia, Lymphoid |                      1                                                   |      5  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  A  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  A  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +                                             |  49        |
      Peyer's Patch, Hyperplasia, Lymphoid | 1                                                                        |      5  1.4|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Basophilic Focus, Multiple           |    X                                                                     |      1     |
      Fatty Change, Diffuse                |                                                                          |      1  2.0|
      Fatty Change, Focal                  |                                                                          |      1  2.0|
      Granuloma                            |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |     10  1.2|
      Mitotic Alteration                   |                                                                          |      1  1.0|
      Necrosis, Focal                      |                                                                          |      3  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |      1  3.0|
      Centrilobular, Fatty Change, Diffuse |                                                                          |      1  2.0|
      Periportal, Fatty Change, Diffuse    |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 1                                                                        |     12  1.7|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 1                       2  1                                             |     21  1.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +                                             |  49        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization, Focal                | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                   +                                                      |   1        |
      Artery, Inflammation, Chronic Active |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Arteriole, Thrombosis, Multifocal    |                                                                          |      1  3.0|
      Myocardium, Degeneration             |                                                                          |      1  2.0|
      Ventricle, Thrombosis                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +                                             |  50        |
      Capsule, Ectopic Tissue              |    1                 2                                                   |      4  1.8|
      Capsule, Hyperplasia, Multifocal     | 2  3  2     1  3  2  2  3  3                                             |     50  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +                                             |  49        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Multifocal              |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M     +  +  M  +  M  +                                             |  35        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           | 2                                                                        |      3  1.7|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    | 1                                                                        |      2  1.5|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 | 2                 4  2                                                   |     16  2.4|
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Dilatation                           |                                                                          |      7  2.9|
      Hyperplasia, Cystic                  | 3  4  2     1  2     2  1  1                                             |     44  2.2|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +  +                                             |  50        |
      Atrophy, Focal                       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +                                             |  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      2  4.0|
      Mandibular, Pigmentation, Hemosiderin|                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +                                             |  48        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |                   2                                                      |      4  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +  +  M  +  +  +                                             |  46        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Depletion Lymphoid                   |                3        2                                                |      4  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +  +  +  M  +                                             |  45        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                | 1     1     4                                                            |     21  1.4|
      Ulcer                                |             4                                                            |      1  4.0|
      Epithelium, Hyperplasia              |                            2                                             |      2  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Fibrous Osteodystrophy               | 2                                                                        |      6  1.8|
      Hyperplasia                          |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Mineralization, Multifocal           |       1        1        1  1                                             |     34  1.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +     +        +  +  +                                             |  36        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Atelectasis, Focal                   |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      3  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |             2                                                            |      3  1.7|
      Artery, Hypertrophy, Multifocal      |    3  3                                                                  |     10  3.0|
      Artery, Thrombosis                   |                                                                          |      1  1.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Lymphocyte             |    3                                                                     |      4  2.5|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |    3  2                                                                  |     16  2.3|
      Pleura, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lumen, Foreign Body                  |                                                                          |      4  1.0|
      Mucosa, Degeneration, Hyaline        | 1     1     1           2  3                                             |     28  1.7|
      Mucosa, Inflammation, Chronic        |                                                                          |      2  1.5|
      Mucosa, Inflammation, Chronic Active |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                2                                                         |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |       1     1              1                                             |     11  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2|                                            |            |
                                           | 1| 9| 2| 6| 4| 5| 2| 0| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |     14  1.6|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Glomerulus, Amyloid Deposition       |                      2                                                   |      3  2.0|
      Renal Tubule, Degeneration, Focal    |       1                                                                  |      4  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  M  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    | 1  2  1                    1                                             |     20  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 5| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 2|             
                                           | 9| 1| 2| 2| 2| 6| 2| 6| 9| 1| 0| 2| 1| 2| 9| 1| 9| 0| 0| 1| 9| 9| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                         +                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +     +        +  +  +  +  +     +           +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +     +        +  +  +  +  +     +           +        +      |             
      Peyer's Patch, Angiectasis           |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |    3  1     2                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   |          +                 +        +  +                 +  +        +   |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                             4            |             
      Infiltration Cellular, Lymphocyte    |          2                                               2               |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Lipofuscin             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                     +              +                     |             
      Amyloid Deposition                   |                                                                          |             
      Acinus, Atrophy                      |                                                    4                     |             
      Duct, Cyst                           |                                                    4                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                         +|             
      Diverticulum                         |                                                                         2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
      Capsule, Hyperplasia, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 5| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 2|             
                                           | 9| 1| 2| 2| 2| 6| 2| 6| 9| 1| 0| 2| 1| 2| 9| 1| 9| 0| 0| 1| 9| 9| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                    +                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                               +     +           +  +        +           +|             
      Cyst                                 |                                                 3  3        3           4|             
      Pigmentation, Hemosiderin            |                                                    3                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                  3                 3           2         |             
      Hyperplasia, Cystic                  | 3  4  4  3  4     4     3     2  2  1  2  4  2  1  1  4  1  2  1  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +     +              +  +           +                        |             
      Iliac, Hyperplasia, Lymphoid         |                                                 1                        |             
      Mandibular, Hyperplasia, Lymphoid    |             2                                                            |             
      Mediastinal, Hyperplasia, Lymphoid   |                                  2                                       |             
      Mediastinal, Mineralization          |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                                    |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +           +  +        +  +  +  +           +        +  +   |             
      Ectopic Tissue                       |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                     +                                    |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +              +  +  +  +  +        +  +  +  +  +     +     +   |             
      Inflammation, Chronic                | 2  1     2                    1  1           2  1  1  2                  |             
      Epithelium, Hyperplasia              | 2  1                                                                     |             
      Epithelium, Mitotic Alteration       |                                                       1                  |             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 5| 3| 5| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 2|             
                                           | 9| 1| 2| 2| 2| 6| 2| 6| 9| 1| 0| 2| 1| 2| 9| 1| 9| 0| 0| 1| 9| 9| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                         2           2           1  2  4                  |             
      Artery, Hypertrophy, Multifocal      |                                     4     2  2                 4  4      |             
      Artery, Mineralization, Multifocal   |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                                          |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |    2                                                                     |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |    2  2                                   2  2                 2  2      |             
      Pleura, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |       2                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
      Mucosa, Degeneration, Hyaline        |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +     +     +  +        +  +                                 |             
      Infiltration Cellular, Lymphocyte    |             4     4     3  2                                             |             
      Metaplasia, Osseous                  |                            2                                             |             
      Renal Tubule, Degeneration, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 2| 5| 3| 2| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 6| 5| 3|             
                                           | 6| 1| 9| 6| 0| 9| 9| 1| 1| 8| 0| 1| 0| 1| 0| 8| 2| 9| 0| 0| 6| 6| 2| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                    +     +                 +     +              +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +                    +     +                 A                    A      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                    A     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A                    A     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                    A     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +                    A     M                 A     +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +                 A  +  +     +  +  +  +  A  +  +     +        A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A                    A     +                 A     +              A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A                    A     +                 A     +              A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +                 A  +  +     +  +  +  +  A  +  +     +        A     +|             
      Peyer's Patch, Angiectasis           |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +                    +  +  +     +           +     +              +      |             
      Cytoplasmic Alteration, Focal        |                         2                                                |             
      Fatty Change, Diffuse                |                                              3                           |             
      Granuloma                            |                                                    2                     |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis, Focal                      |                                                    1              3      |             
      Pigmentation, Lipofuscin             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Fat, Necrosis, Focal                 |                            4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                    A     +                 A     +              +      |             
      Amyloid Deposition                   |                            2                                             |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                    +     +                 +     +              +      |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                    1                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +                    +     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +                    +     +                 A     +              +      |             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +                    +     +                 A     +              +      |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                    +     +                 +     +              +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +                    +     +                 +     +              +      |             
      Capsule, Hyperplasia, Multifocal     | 2                    1     1                       2              2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +                    +     +                 A     +              +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 2| 5| 3| 2| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 6| 5| 3|             
                                           | 6| 1| 9| 6| 0| 9| 9| 1| 1| 8| 0| 1| 0| 1| 0| 8| 2| 9| 0| 0| 6| 6| 2| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +                    +     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                    A     +                 A     +              +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M                    M     M                 M     M              M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | A                    +     +  +           +  +     +              +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                    +     +  +              A     +              +      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +                 +  +     +                 A  +  +  +           +      |             
      Cyst                                 |                   2                             2     4                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +     +  +  +  +     +  +  +     A  +  +  +  +        +     +|             
      Dilatation                           |             4     3                                                      |             
      Hyperplasia, Cystic                  |    4  2     2     2     3  1     2  2  4        2  1  3  2              2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +                    +     +                 +     +              +      |             
      Hyperplasia, Neutrophil              |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +        +     +  +  +           A     +     +        +      |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Mineralization          |                            4                                             |             
      Renal, Hyperplasia, Lymphoid         |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +                    +     M                 A     +              +      |             
      Hemorrhage                           | 2                                                                 1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +           +  +  +  +  +  +        +  A  +  +              +     +|             
      Ectopic Tissue                       |                                                                   X      |             
      Hematopoietic Cell Proliferation     |                            3                       3                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +              +     +                 M     +              +      |             
      Depletion Lymphoid                   | 3                          3                       3                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                    +     +                 M     +              +      |             
      Inflammation, Chronic                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | M           +        +     +           +  +  +     +     +        +      |             
      Inflammation, Chronic                |             2                          1  1                              |             
      Epithelium, Hyperplasia              |                                                                          |             
      Epithelium, Mitotic Alteration       |                                                                          |             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 2| 5| 3| 2| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 6| 5| 3|             
                                           | 6| 1| 9| 6| 0| 9| 9| 1| 1| 8| 0| 1| 0| 1| 0| 8| 2| 9| 0| 0| 6| 6| 2| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6250PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Focal                           |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +                    +     +                 +     +              +      |             
      Fibrous Osteodystrophy               |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                    +     +                 +     +              +      |             
      Hemorrhage                           |                                                                   3      |             
      Mineralization, Multifocal           |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +     +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Artery, Hypertrophy, Multifocal      |                                        3                                 |             
      Artery, Mineralization, Multifocal   |                            4                                             |             
      Artery, Thrombosis                   |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                   2                             2                        |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |    1              2                    2        2                        |             
      Pleura, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +                    +     +                 +     +              +      |             
      Mucosa, Degeneration, Hyaline        | 1                                            2     3              2      |             
      Respiratory Epithelium, Hyperplasia  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                    +     +                 +     +              +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Cornea, Inflammation, Chronic        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +                 +                       A     +              +      |             
      Infiltration Cellular, Lymphocyte    |    2                                                                     |             
      Metaplasia, Osseous                  |                                                                          |             
      Renal Tubule, Degeneration, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A                    +     +                 +     +              +      |             
      Infiltration Cellular, Lymphocyte    |                                              2     1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 7| 4| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3|                                            |            |
                                           | 3| 6| 0| 6| 6| 6| 9| 2| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M                                                                        |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M                                                                        |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                                                                        |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A                                                                        |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A                                                                        |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A     +              +  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A     +              +  +  +                                             |  28        |
      Peyer's Patch, Angiectasis           |       3                                                                  |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | A                    +     +                                             |  17        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Fatty Change, Diffuse                |                                                                          |      1  3.0|
      Granuloma                            |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Pigmentation, Lipofuscin             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis, Focal                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A                                                                        |   6        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      1  4.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | M                                                                        |   6        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                                                                        |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |   7        |
      Diverticulum                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |   6        |
      Hemorrhage                           | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | M                                                                        |   6        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 7| 4| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3|                                            |            |
                                           | 3| 6| 0| 6| 6| 6| 9| 2| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                                                                        |   7        |
      Capsule, Hyperplasia, Multifocal     |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                                                                        |   6        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                                                                        |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A                                                                        |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M                                                                        |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M                                                                        |   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M                                                                        |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  15        |
      Cyst                                 |                                                                          |      7  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +           +  +  +  +                                             |  45        |
      Dilatation                           |                                                                          |      5  3.0|
      Hyperplasia, Cystic                  |       1           1  2  4  3                                             |     41  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |   7        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M                 +                                                      |  17        |
      Iliac, Hyperplasia, Lymphoid         |                   4                                                      |      2  2.5|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Mineralization          |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M                                                                        |   5        |
      Hemorrhage                           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | M                    +  +  +                                             |  29        |
      Ectopic Tissue                       |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                            1                                             |      3  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                                                        |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 7| 4| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3|                                            |            |
                                           | 3| 6| 0| 6| 6| 6| 9| 2| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |   6        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +              +                                                   |  27        |
      Inflammation, Chronic                |                      1                                                   |     13  1.4|
      Epithelium, Hyperplasia              |                                                                          |      2  1.5|
      Epithelium, Mitotic Alteration       |                                                                          |      1  1.0|
      Subcutaneous Tissue, Mineralization, |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |   7        |
      Fibrous Osteodystrophy               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | M                                                                        |   6        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Mineralization, Multifocal           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | M     +           +  +  +  +                                             |  49        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      5  2.2|
      Artery, Hypertrophy, Multifocal      |                      1     3                                             |      8  2.9|
      Artery, Mineralization, Multifocal   |                                                                          |      1  4.0|
      Artery, Thrombosis                   |                   1                                                      |      1  1.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                   1  1     1                                             |     13  1.7|
      Pleura, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M                                                                        |   6        |
      Mucosa, Degeneration, Hyaline        |                                                                          |      4  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 7| 4| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3|                                            |            |
                                           | 3| 6| 0| 6| 6| 6| 9| 2| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    6250PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | M                                                                        |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                    +  +                                                |  14        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      5  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Renal Tubule, Degeneration, Focal    |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |   6        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|             
                                           | 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +     +  +  +  +  M        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +  +  +  +     +  +  A  +  A        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +     +  +  A  +  +        +  +  +  +  +  +     +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +     +  +  A  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +     +  +  A  +  A        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +     +  +  A  +  A        +  +  +  +  +  M     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +     +  +  A  +  A        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +     +  +  A  +  M        +  +  +  +  +  +     +|             
      Hemorrhage                           |                                                             1            |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fatty Change, Diffuse                |                                  2                                       |             
      Hematocyst                           |                                                                3         |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Infiltration Cellular, Lymphocyte    |                                                                   2     1|             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                         1                                         1      |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       1                 1     1  2                             1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                                             1            |             
      Necrosis, Multifocal                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Bacterium                            |                                                             X            |             
      Infiltration Cellular, Lymphocyte    |                                  1                                       |             
      Aortic Valve, Thrombosis             |                                                             4            |             
      Artery, Hypertrophy, Multifocal      |                                                    2                     |             
      Mitral Valve, Inflammation, Acute    |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  M  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|             
                                           | 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Ectopic Tissue              |                                                          2               |             
      Capsule, Hyperplasia, Multifocal     | 2     3  2  2  3  2  2  3     3  2  2  2  2        3  3  2     2  3     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  M  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                2                 3                                       |             
      Hypertrophy, Focal                   |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Hyperplasia, Multifocal              | 2                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     M  +  +  +  +  +  +     M  M  M  +  M        +  +  M  M  +  M     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  M  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |          1                                                     2         |             
      Pars Distalis, Hypertrophy, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  M  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Follicle, Cyst, Multiple             |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Abscess                              |                                                                          |             
      Cyst                                 | 2     3  2  3                                      2              2     3|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                  3                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Dilatation                           |                                                             3            |             
      Hyperplasia, Cystic                  | 3        2  2     2  2  1     1        1           3  1  3     3  4     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Atrophy, Focal                       |                                                                          |             
      Hyperplasia, Neutrophil              |                                                          3  3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  +     +  +  M  +  +        +  +  +  +  M  +     +|             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia, Histiocytic      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                  4                                       |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|             
                                           | 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                   2      |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +     +  +  M  +  +        +  +  +  +  M  +     +|             
      Abscess                              |                                                             3            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     |                                  3                       3  2            |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Depletion Lymphoid                   |                                     3                 3     3            |             
      Ectopic Parathyroid Gland            |             X                                                            |             
      Hyperplasia, Lymphoid                |                                                    2                    4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +  +  +  +     +  +  +  M  M        +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                          3               |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Inflammation, Acute                  |                                     1                                    |             
      Inflammation, Chronic                | 1        1  1     2                                1                     |             
      Ulcer                                |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Fibrous Osteodystrophy               |          3  1                                      2           3  4     1|             
      Coccygeal, Fracture                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Mineralization, Multifocal           | 1     2  1  2  1     2        1        1           2     2  1  2         |             
      Arteriole, Meninges, Bacterium       |                                                             X            |             
      Arteriole, Meninges, Thrombosis      |                                                             1            |             
      Meninges, Inflammation, Acute        |                                                             1            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +        +  +     +  +  +     +        +  +        +     +     +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Hemorrhage, Focal                    |                                                                          |             
      Alveolus, Edema                      |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|             
                                           | 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Hypertrophy, Multifocal      |       3  3  1                 2                       4     3            |             
      Interstitium, Inflammation, Acute    |                                                             2            |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |       2  2  1                 2                       2                  |             
      Pleura, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Mucosa, Degeneration, Hyaline        |             2        1        2     2  1  2        2  1  2  1  2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |             1                 1        1           1           1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Embolus Bacterial                    |                                                             X            |             
      Hydronephrosis                       |                                                                          |             
      Infiltration Cellular, Lymphocyte    |             1        2              2  4                          2      |             
      Inflammation, Acute, Multifocal      |                                                             2            |             
      Glomerulus, Inflammation, Chronic    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +     +|             
      Hemorrhage                           |                                                             1            |             
      Infiltration Cellular, Lymphocyte    |             1     3     1     1  2                 1           1  2     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|             
                                           | 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    12500PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +     +  +  +  +  +  +  M  +     +        +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +     +  +  +  +  +  A  +  +     +        +  +  +  +  A  A|             
      Peyer's Patch, Hyperplasia, Lymphoid |       2     2        1                          1                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +     +  +  M  +  +  +  +  M     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +     +  +  +  +  +  A  +  +     +        +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +     +  M  +  +  +  A  A  M     +        +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +     +  +  +  +  +  M  A  +     +        +  +  +  +  A  A|             
      Hemorrhage                           |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                         4                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                         4                                                |             
      Fatty Change, Diffuse                |                                                                         3|             
      Hematocyst                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis, Focal                      |    4                                2                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            2     2                                       |             
      Acinus, Atrophy                      |                                  4                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  M|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       1              2  2  2  1  1     2                       1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis, Multifocal                 |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Aortic Valve, Thrombosis             |                                                                          |             
      Artery, Hypertrophy, Multifocal      |                                                                          |             
      Mitral Valve, Inflammation, Acute    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|             
                                           | 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    12500PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Ectopic Tissue              |                                                                          |             
      Capsule, Hyperplasia, Multifocal     | 3  2  2     2  2     2  2  2  2  2  2  2  2     2        2  1  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      2   |             
      Hyperplasia, Focal                   | 2                                                                        |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     M  M     +  +  +  +  M  M  +  +     +        +  +  +  +  M  M|             
      Hyperplasia                          |                                                                3         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             2                                                            |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hypertrophy, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  M|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |    2                                                                     |             
      Follicle, Cyst, Multiple             |                                                                2         |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Abscess                              |                                  4                                       |             
      Cyst                                 | 2  2  3     2              3  2  4                          4  3         |             
      Hemorrhage                           |                                     2                                    |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Dilatation                           |       3                                         4                        |             
      Hyperplasia, Cystic                  | 2  1  2     3  1     2  2  2  1  2        2     2        2  3  2  1     1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Atrophy, Focal                       |                                                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  +|             
      Iliac, Hemorrhage                    |    2                                                                     |             
      Iliac, Hyperplasia, Histiocytic      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|             
                                           | 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    12500PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Renal, Hemorrhage                    |    4                                                                     |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hemorrhage                           |    3                                                                     |             
      Hyperplasia, Lymphoid                |       4                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Capsule, Inflammation, Chronic       |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +     +  +  +  +  +  M  +  +     +        +  +  +  +  A  +|             
      Depletion Lymphoid                   |                                        2                                 |             
      Ectopic Parathyroid Gland            |                                        X                                 |             
      Hyperplasia, Lymphoid                | 3                                                              3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +     +  +  +  M  +  +  +  +     M        +  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    1  1     1                          1        1                 1      |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                            1                                             |             
      Coccygeal, Fracture                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Mineralization, Multifocal           | 1     1              2  1     1     1  1        2        1     1  1  2   |             
      Arteriole, Meninges, Bacterium       |                                                                          |             
      Arteriole, Meninges, Thrombosis      |                                                                          |             
      Meninges, Inflammation, Acute        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  M  +     +  +     +  +  +  +  +     +  +     +        +  +  +  +      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Hemorrhage, Focal                    |    3                                2                                    |             
      Alveolus, Edema                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|             
                                           | 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    12500PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    3                                                                     |             
      Artery, Hypertrophy, Multifocal      | 3              4     4  3     2  3     2        2        2  2     2      |             
      Interstitium, Inflammation, Acute    |                                                                          |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Lymphocyte                      | 3                                                                        |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                               2                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      | 3              4     3  2     2  2     2        2        2  2     1      |             
      Pleura, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  M  +|             
      Mucosa, Degeneration, Hyaline        | 3  1           1     1        2  1  1     1     2        3  1  1  1      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 1                                               2           1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +     +  +  +  +  +  +  +  +     +        +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                                          |             
      Hydronephrosis                       |                                                                   1      |             
      Infiltration Cellular, Lymphocyte    |                               1                                1         |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     M  +     +  +  +  +  +  +  +  +     +        +  +  +  +  A  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1              1           1     1     1        2        2     1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +  +  +  +     +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  M     +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +                                             |  45        |
      Peyer's Patch, Hyperplasia, Lymphoid |    1                                                                     |      5  1.4|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +     +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  M     +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +                                             |  43        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Peyer's Patch, Hyperplasia, Lymphoid |    2     1  1                                                            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  4.0|
      Fatty Change, Diffuse                |                                                                          |      2  2.5|
      Hematocyst                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                1     2                                                   |      4  1.5|
      Necrosis, Focal                      |       1     4                                                            |      4  2.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +     +                                             |  48        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    1           2  1  1                                                   |      8  1.4|
      Acinus, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +     +                                             |  47        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    1  2  1     2  1  2     1                                             |     20  1.4|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +                                             |  48        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Bacterium                            |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Aortic Valve, Thrombosis             |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Artery, Hypertrophy, Multifocal      |                                                                          |      1  2.0|
      Mitral Valve, Inflammation, Acute    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +                                             |  48        |
      Capsule, Ectopic Tissue              |                                                                          |      1  2.0|
      Capsule, Hyperplasia, Multifocal     | 2  2  1  2  2  3  2  2     2                                             |     48  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +                                             |  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      3  2.3|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +                                             |  48        |
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  M     +                                             |  32        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +                                             |  48        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                1                                                         |      3  1.3|
      Pars Distalis, Hypertrophy, Focal    |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +                                             |  46        |
      Infiltration Cellular, Lymphocyte    |       2                                                                  |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Follicle, Cyst, Multiple             |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  |       2                                                                  |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Abscess                              |                                                                          |      1  4.0|
      Cyst                                 | 4              2     1     2                                             |     20  2.6|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +     +                                             |  48        |
      Dilatation                           |                                                                          |      3  3.3|
      Hyperplasia, Cystic                  | 2  2  1     1  2  2  2     2                                             |     39  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +     +                                             |  48        |
      Atrophy, Focal                       |       2           2                                                      |      2  2.0|
      Hyperplasia, Neutrophil              |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +     +                                             |  46        |
      Iliac, Hemorrhage                    |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Histiocytic      |             2                                                            |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |                   3                                                      |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  4.0|
      Mandibular, Hyperplasia, Lymphoid    |       4                                                                  |      2  3.5|
      Mediastinal, Hyperplasia, Lymphoid   |             1                                                            |      2  1.5|
      Renal, Hemorrhage                    |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +                                             |  46        |
      Abscess                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Capsule, Inflammation, Chronic       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M     +                                             |  46        |
      Depletion Lymphoid                   |                                                                          |      4  2.8|
      Ectopic Parathyroid Gland            |                                                                          |      2     |
      Hyperplasia, Lymphoid                |    3              2                                                      |      6  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +     +                                             |  43        |
      Hyperplasia                          |             2                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |       1                    1                                             |     13  1.1|
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Fibrous Osteodystrophy               |             2        2                                                   |      9  2.1|
      Coccygeal, Fracture                  |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Lymphocyte    |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Mineralization, Multifocal           | 1     1  1  1  2  1        2                                             |     31  1.4|
      Arteriole, Meninges, Bacterium       |                                                                          |      1     |
      Arteriole, Meninges, Thrombosis      |                                                                          |      1  1.0|
      Meninges, Inflammation, Acute        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +     +                                             |  39        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hemorrhage, Focal                    |                                                                          |      2  2.5|
      Alveolus, Edema                      |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
      Artery, Hypertrophy, Multifocal      | 1     1  2                 3                                             |     21  2.5|
      Interstitium, Inflammation, Acute    |                                                                          |      1  2.0|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  3.0|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Lymphocyte             |                2           3                                             |      3  2.3|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      | 1     2  2     2     2     4                                             |     22  2.1|
      Pleura, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +     +                                             |  48        |
      Mucosa, Degeneration, Hyaline        | 2           1     2                                                      |     27  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |          3                                                               |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                   1                                                      |      9  1.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +     +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   2        |
      Cornea, Inflammation, Chronic Active |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3|                                            |            |
                                           | 2| 2| 1| 2| 1| 9| 1| 1| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    12500PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Embolus Bacterial                    |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |             2  2                                                         |      9  1.9|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Glomerulus, Inflammation, Chronic    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +                                             |  47        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |    1           1     2     1                                             |     21  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +     +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                          2     2     3  2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +     +  +|             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                       2  3               |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cyst                                 |                                                                          |             
      Cytomegaly, Focal                    | 2                                         2                              |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Granuloma, Multifocal                |                            1                                             |             
      Infarct                              |                                              4                           |             
      Infiltration Cellular, Lymphocyte    |                         2                                                |             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |       X                                                                  |             
      Necrosis, Focal                      |                                  2                                       |             
      Syncytial Alteration                 |                                                             1            |             
      Centrilobular, Cytomegaly, Diffuse   |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |                                                 2                        |             
      Portal, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                      1                 2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                   1                 1  1     1           1               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Abscess                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mucosa, Vacuolization Cytoplasmic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Capsule, Hyperplasia                 |             2                                                            |             
      Capsule, Hyperplasia, Multifocal     |                2                    1  2  2  1  2     2  3     2     3  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia, Focal                   |                                                                2         |             
      Hypertrophy, Focal                   |                                                                      4   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          | 2                 2                                      2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     +  M  M  M  M  +     +  +  +  +  +  +  +  +  +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |                         2                                                |             
      Follicle, Cyst, Multiple             |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Granuloma Sperm                      |                                              3                           |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                            +        +     +  +         |             
      Dilatation                           |                                              4        2     3            |             
      Hyperplasia                          |                                                                2         |             
      Inflammation, Chronic                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Spermatocele                         |                            3                                             |             
      Seminiferous Tubule, Dilatation      |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Axillary, Hemorrhage                 |                3                                                         |             
      Axillary, Hyperplasia, Lymphoid      |                                                       2                  |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Pigmentation, Hemosiderin  |                                                       2                  |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Pigmentation, Hemosiderin|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     M  M|             
      Hemorrhage                           | 2                                   1  1     1        2                  |             
      Hyperplasia, Lymphoid                |             1              2                          1                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                              3  3                        |             
      Hyperplasia, Lymphoid                |                                        3                 2               |             
      Pigmentation, Hemosiderin            |                                     1                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +     +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +     +  +|             
      Depletion Lymphoid                   |                                  3                                       |             
      Thymocyte, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M     M  M  M  M  M  M     M  M  +  M  M  M  M  M  M  M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Chronic                |                         2                 1                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                       3                  |             
      Epithelium, Hyperplasia              |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mineralization, Multifocal           | 2     2     2  2     1  1        1  1  2  2        3  1  2  2  3     1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +           +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Giant Cell                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |                3                                                         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Bronchiole, Inflammation, Chronic    |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                                          |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mucosa, Degeneration, Hyaline        |                         2                                                |             
      Mucosa, Inflammation, Chronic Active |                                                                         1|             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
      Conjunctiva, Inflammation, Chronic   |       2                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |       1     1        1     1           1                    1        1   |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Nephropathy, Chronic                 |                   1                          1                           |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Mineralization, Multifocal   | 1                                         1                             1|             
      Glomerulus, Amyloid Deposition       |                         3                                                |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Renal Tubule, Degeneration, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                                         |             
      Inflammation, Acute                  |                                                                          |             
      Bulbourethral Gland, Ectasia         |                4                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |       1                                                                  |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|             
                                           | 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  M     +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  M  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                         2  2                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Serosa, Inflammation, Suppurative    |                                                             4            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  A     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  A     +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                   1                 3                                2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Cyst                                 |                                                                         4|             
      Cytomegaly, Focal                    |                                                    2                    2|             
      Fatty Change, Diffuse                |                2                                                         |             
      Fatty Change, Focal                  |                                                 3                        |             
      Granuloma, Multifocal                |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                   1                                                      |             
      Mitotic Alteration                   |                                                                         3|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Syncytial Alteration                 |                                                                          |             
      Centrilobular, Cytomegaly, Diffuse   |                                              3                           |             
      Centrilobular, Necrosis, Diffuse     |                                                                          |             
      Portal, Inflammation, Chronic        |          1                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 3           1     1                 2        1  1  1                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Abscess                              |                                        1                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Mucosa, Vacuolization Cytoplasmic    |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|             
                                           | 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Capsule, Hyperplasia                 |                                                                          |             
      Capsule, Hyperplasia, Multifocal     | 3  2  2     1     1  3  1  1        3     2  3  2  1     1           1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |    2                                      2     1        2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Hyperplasia                          |                               2              2                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  +  +  M     +  +  +  +  M  +     +  M  M     +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Follicle, Cyst, Multiple             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                            +  +         |             
      Necrosis                             |                                                             4  4         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +                                                         |             
      Dilatation                           |                2                                                         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Inflammation, Acute                  |                3                                            4  3         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Fibrosis                             |                   2                                                      |             
      Inflammation, Acute                  |                                                                4         |             
      Inflammation, Chronic                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Spermatocele                         |                                                                          |             
      Seminiferous Tubule, Dilatation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Hyperplasia, Neutrophil              |          3                             4                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|             
                                           | 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Axillary, Hemorrhage                 |                                                                          |             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                         4|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                         2|             
      Inguinal, Pigmentation, Hemosiderin  |       2                                                                  |             
      Mandibular, Hyperplasia, Lymphoid    | 3                                            3                           |             
      Mandibular, Pigmentation, Hemosiderin|                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  M  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Hemorrhage                           |    2  2                    1        2                    1              3|             
      Hyperplasia, Lymphoid                |                   2     1           1           2                    1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |          3                    1     2  4                    4  3        1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  +  M  +     +  +  +  +  M  +     +  +  +     M  +|             
      Depletion Lymphoid                   |                               1        2                                 |             
      Thymocyte, Necrosis                  |                3                                            3  4         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M  M     M  M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Inflammation, Chronic                |    1                                   3                 1               |             
      Inflammation, Chronic Active         |          4                          4                                    |             
      Ulcer                                |          4                    4     3  3                                 |             
      Epithelium, Hyperplasia              |          3                                                               |             
      Hair Follicle, Atrophy               |                                        3                                 |             
      Subcutaneous Tissue, Abscess         |                   4                                                      |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Mineralization, Multifocal           |       2  1  2     1  2  1  2  1     4  2     1  3  2     3           3  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +     +  +  +  +  +     +     +  M  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Giant Cell                           |          2                             2                                 |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|             
                                           | 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          2                             3                                 |             
      Bronchiole, Inflammation, Chronic    |          3                             4                                 |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                                          |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Mucosa, Degeneration, Hyaline        |    2                                                                     |             
      Mucosa, Inflammation, Chronic Active |    1  1                                                                  |             
      Respiratory Epithelium, Hyperplasia  | 1  2  1                                                              2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Conjunctiva, Inflammation, Chronic   |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |       1     1           1                          1                 1  2|             
      Infiltration Cellular, Mixed Cell    |                                        3                                 |             
      Nephropathy, Chronic                 |    1     2                             2     1                           |             
      Cortex, Cyst                         |                                     1                                    |             
      Cortex, Mineralization, Multifocal   |    1                                                                     |             
      Glomerulus, Amyloid Deposition       |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                4         |             
      Pelvis, Inflammation, Chronic Active |                2                                                         |             
      Renal Tubule, Degeneration, Focal    |                                                    1                     |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                +         |             
      Inflammation, Acute                  |                                                                4         |             
      Bulbourethral Gland, Ectasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |                                              1                       2   |             
      Inflammation, Acute                  |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 4| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3|                                            |            |
                                           | 0| 2| 0| 6| 6| 2| 1| 2| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +     +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +        M  +  +     +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +        +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +        +  +  +     +                                             |  48        |
      Peyer's Patch, Hyperplasia, Lymphoid |                1                                                         |      7  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +        +  +  M     +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +        +  +  +     +                                             |  48        |
      Serosa, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +        +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +        +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +        +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +        +  +  +     +                                             |  47        |
      Peyer's Patch, Hyperplasia, Lymphoid |                      2                                                   |      6  2.2|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +     +                                             |  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Cytomegaly, Focal                    |                                                                          |      4  2.0|
      Fatty Change, Diffuse                |                                                                          |      1  2.0|
      Fatty Change, Focal                  |                2                                                         |      2  2.5|
      Granuloma, Multifocal                |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |       1                                                                  |      3  1.3|
      Mitotic Alteration                   |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Syncytial Alteration                 |                                                                          |      1  1.0|
      Centrilobular, Cytomegaly, Diffuse   |                                                                          |      1  3.0|
      Centrilobular, Necrosis, Diffuse     |                                                                          |      1  2.0|
      Portal, Inflammation, Chronic        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   1        |
      Infiltration Cellular, Lymphocyte    |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +     +                                             |  49        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       2                                                                  |      4  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +     +                                             |  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                   1                                                      |     13  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +     +                                             |  49        |
      Abscess                              |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 4| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3|                                            |            |
                                           | 0| 2| 0| 6| 6| 2| 1| 2| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +     +                                             |  49        |
      Mucosa, Vacuolization Cytoplasmic    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +     +                                             |  50        |
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +     +                                             |  50        |
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
      Capsule, Hyperplasia, Multifocal     |    3  2        1  2                                                      |     30  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +     +                                             |  50        |
      Hyperplasia, Focal                   |                   2                                                      |      2  2.0|
      Hypertrophy, Focal                   |                3                                                         |      6  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +     +                                             |  49        |
      Hyperplasia                          |    2  3                                                                  |      7  2.1|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  +     +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  M     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +     +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Follicle, Cyst, Multiple             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +        +  +  +     +                                             |  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   3        |
      Necrosis                             |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   6        |
      Dilatation                           |                                                                          |      4  2.8|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +        +  +  +     +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +        +  +  +     +                                             |  49        |
      Fibrosis                             |    4  3                                                                  |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 4| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3|                                            |            |
                                           | 0| 2| 0| 6| 6| 2| 1| 2| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +        +  +  +     +                                             |  50        |
      Spermatocele                         |                                                                          |      1  3.0|
      Seminiferous Tubule, Dilatation      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +     +                                             |  50        |
      Hyperplasia, Neutrophil              |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | A  +  +        +  +  +     +                                             |  48        |
      Hyperplasia, Lymphoid                |                            3                                             |      2  3.0|
      Axillary, Hemorrhage                 |                                                                          |      1  3.0|
      Axillary, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Inguinal, Pigmentation, Hemosiderin  |                                                                          |      2  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                      3                                                   |      3  3.0|
      Mandibular, Pigmentation, Hemosiderin|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +        +  +  +     +                                             |  45        |
      Hemorrhage                           |                   3        1                                             |     13  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      8  1.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +     +                                             |  50        |
      Congestion                           | 3                                                                        |      1  3.0|
      Hematopoietic Cell Proliferation     |    4                       1                                             |     11  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  +  +     +                                             |  44        |
      Depletion Lymphoid                   |                                                                          |      3  2.0|
      Thymocyte, Necrosis                  | 2                                                                        |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M        M  M  M     M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +     +                                             |  50        |
      Inflammation, Chronic                | 2                                                                        |      7  1.6|
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
      Ulcer                                |                                                                          |      5  3.4|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
      Hair Follicle, Atrophy               |                                                                          |      1  3.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 4| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3|                                            |            |
                                           | 0| 2| 0| 6| 6| 2| 1| 2| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +     +                                             |  50        |
      Mineralization, Multifocal           |    3  2        2     2     2                                             |     38  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +        +  +  +     +                                             |  41        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +     +                                             |  50        |
      Giant Cell                           |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       3              2                                                   |      3  2.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.5|
      Bronchiole, Inflammation, Chronic    |                                                                          |      2  3.5|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Lymphocyte                      |       2           2                                                      |      2  2.0|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  +  +     +                                             |  50        |
      Mucosa, Degeneration, Hyaline        |                      1                                                   |      3  1.7|
      Mucosa, Inflammation, Chronic Active |                                                                          |      3  1.0|
      Respiratory Epithelium, Hyperplasia  |                   1  1                                                   |      6  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Conjunctiva, Inflammation, Chronic   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +     +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |    1  1        1     1     3                                             |     18  1.2|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 4| 7| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3|                                            |            |
                                           | 0| 2| 0| 6| 6| 2| 1| 2| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy, Chronic                 |                   1        4                                             |      8  1.6|
      Cortex, Cyst                         |                                                                          |      1  1.0|
      Cortex, Mineralization, Multifocal   | 2                                                                        |      5  1.2|
      Glomerulus, Amyloid Deposition       |                                                                          |      1  3.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  4.0|
      Pelvis, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Renal Tubule, Degeneration, Focal    |                      2                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Bulbourethral Gland, Ectasia         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +        +  +  +     +                                             |  48        |
      Infiltration Cellular, Lymphocyte    |    1                       1                                             |      5  1.2|
      Inflammation, Acute                  |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 0| 3| 2| 5| 2| 3| 3| 3| 1| 5| 0| 5| 5| 3| 2| 1| 3| 3| 5| 5|             
                                           | 0| 9| 1| 8| 2| 1| 1| 9| 6| 9| 0| 2| 1| 1| 6| 7| 6| 6| 0| 9| 4| 1| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Gallbladder                             |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  +     +           +  +     +     +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +                             +     +                           |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +  +     +           +  +     +     +                    +      |             
      Hyperplasia, Neutrophil              |                                  3                                       |             
      Peyer's Patch, Hyperplasia, Lymphoid |             2                    3                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +     +  +  +  +  +     +        +  +  +  +  +      |             
      Amyloid Deposition                   |          4                                                               |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Infarct                              | 4                                                                        |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Infiltration Cellular, Mixed Cell    |             2                                                            |             
      Necrosis, Focal                      |                                        3                       2         |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
      Serosa, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +                             +     +                           |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Epithelium, Hyperplasia, Focal       |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +                             +     +                           |             
      Myocardium, Fibrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +                             +     +                           |             
      Capsule, Hyperplasia, Multifocal     |                                        1     1                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          M                             +     +                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +                             +     +                           |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          M                             +     M                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          M                             +     +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 0| 3| 2| 5| 2| 3| 3| 3| 1| 5| 0| 5| 5| 3| 2| 1| 3| 3| 5| 5|             
                                           | 0| 9| 1| 8| 2| 1| 1| 9| 6| 9| 0| 2| 1| 1| 6| 7| 6| 6| 0| 9| 4| 1| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +                             +     +                           |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +        +                                                  +         |             
      Cyst                                 |                                                                4         |             
      Dilatation                           |    3                                                                     |             
      Inflammation, Chronic                |             4                                                  4         |             
                                            __________________________________________________________________________|             
   Prostate                                |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          M                       +  +  +     +                           |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |          +                       +     +     +                           |             
      Seminiferous Tubule, Atrophy         |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +                             +     +                           |             
      Hyperplasia, Neutrophil              |          4                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +                          +     +                           |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +                             +     +                           |             
      Hemorrhage                           |                                        3                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +                 +  +  +  +     +              +  +  +      |             
      Hematopoietic Cell Proliferation     |          4                             4                                 |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +                             +     M                           |             
      Depletion Lymphoid                   |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M                             +     M                           |             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +     +  +     +  +        +     +        +  +               |             
      Inflammation, Chronic                |                                                       3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                       4                  |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 0| 3| 2| 5| 2| 3| 3| 3| 1| 5| 0| 5| 5| 3| 2| 1| 3| 3| 5| 5|             
                                           | 0| 9| 1| 8| 2| 1| 1| 9| 6| 9| 0| 2| 1| 1| 6| 7| 6| 6| 0| 9| 4| 1| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +                             +     +                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +  +     +  +  +     +        +     +     +      |             
      Hemorrhage                           |                                                                          |             
      Mineralization, Multifocal           | 1  1  2  2  2        1     1     2  2  3              2     3     2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +     +  +  +  +  +     +        +  +  +  +  +      |             
      Leukocytosis                         |          3                                                               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Hypertrophy, Multifocal      |                                                                          |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |          +                             +     +                           |             
      Respiratory Epithelium, Hyperplasia  |          2                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +                             +     +                           |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +                       +     +     +                 +         |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                        1                                 |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Mineralization, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +                             +     +                           |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 2| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 2| 7| 3| 9| 3| 3| 5| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 9| 6| 0| 0| 9| 9| 0| 6| 2| 1| 6| 6| 0| 0| 9| 2| 0| 5| 2| 0| 1| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6250PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                   A     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                   +     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                   A     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                   +     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                   +     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +        +     +                             A     +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                   A     +                             A                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +        A     +                             A                  |             
      Peyer's Patch, Hyperplasia, Lymphoid |          4                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                 A     +                             A     +        +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid | 3                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                         1|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Necrosis, Focal                      |                                                    1                     |             
      Hepatocyte, Hyperplasia, Focal       |                               3                                          |             
      Serosa, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                   +     +                             +                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                   +     +                             +                  |             
      Myocardium, Fibrosis                 |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                   +     +                             +                  |             
      Capsule, Hyperplasia, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                   +     +                             +                  |             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   +     +                             +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                   +     +                             +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 2| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 2| 7| 3| 9| 3| 3| 5| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 9| 6| 0| 0| 9| 9| 0| 6| 2| 1| 6| 6| 0| 0| 9| 2| 0| 5| 2| 0| 1| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6250PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +     +                             +                  |             
      Infiltration Cellular, Lymphocyte    |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                   +     +                    +        +                  |             
                                            __________________________________________________________________________|             
   Penis                                   |                   +                                                      |             
      Inflammation, Acute                  |                   3                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                                   +                        |             
      Cyst                                 |                                                                          |             
      Dilatation                           |             2                                                            |             
      Inflammation, Chronic                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Prostate                                |                   A     +                             +                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +     +                                                |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                   +     +                             +                  |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                   +     +                             +                  |             
      Hyperplasia, Neutrophil              |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +  +  +                       +     +                  |             
      Inguinal, Hyperplasia, Plasma Cell   |                      4                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +  +  +                       +     A                  |             
      Hemorrhage                           |                      2                          3                        |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +  +  +  +  +  +           +  +  +     +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      4                                4                  |             
      Hyperplasia, Lymphoid                |                               2                                   2      |             
                                            __________________________________________________________________________|             
   Thymus                                  |                   M     +                             M                  |             
      Depletion Lymphoid                   |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                   M     M                             M                  |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +     +  +  +  +                          +                  |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                      4                                                   |             
      Ulcer                                |                      4                                                   |             
      Epithelium, Hyperplasia              |                                                                          |             
      Subcutaneous Tissue, Edema           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 2| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 2| 7| 3| 9| 3| 3| 5| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 9| 6| 0| 0| 9| 9| 0| 6| 2| 1| 6| 6| 0| 0| 9| 2| 0| 5| 2| 0| 1| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6250PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +     +                    +        +                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +     +  +  +  +  +           +  +  +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                         1                                                |             
      Mineralization, Multifocal           | 1  3     2  3     1  1  1  3  3           2  1  2  3  1  2  2     1  2  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukocytosis                         |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                3         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                       2                  |             
      Artery, Hypertrophy, Multifocal      |                                                    2                     |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                    1                     |             
                                            __________________________________________________________________________|             
   Nose                                    |                   +     +                             +                  |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                   +     +                             +                  |             
      Infiltration Cellular, Lymphocyte    |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Lens, Cataract                       |                                              2                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +  +     +     +              +        +                  |             
      Infarct                              |                4                                                         |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Cortex, Cyst                         |                                              3                           |             
      Cortex, Mineralization, Multifocal   |                   1                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                   A     +                             +                  |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3|                                            |            |
                                           | 9| 1| 9| 9| 2| 9| 2| 2| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +              A                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A              A                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A              A                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A              A                                                         |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +              +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A              A           +                                             |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A              A                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A              A                                                         |   5        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A              A           +                                             |  14        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      3  2.0|
      Hepatocyte, Hyperplasia, Focal       |                                                                          |      1  3.0|
      Serosa, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +              A                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +              A                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | A              A                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A              A                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A              A                                                         |   6        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +              +                                                         |   8        |
      Myocardium, Fibrosis                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +              A                                                         |   7        |
      Capsule, Hyperplasia, Multifocal     |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +              A                                                         |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3|                                            |            |
                                           | 9| 1| 9| 9| 2| 9| 2| 2| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +              A                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +              A                                                         |   7        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M              A                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +              +                                                         |   7        |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +              A                                                         |   7        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +              +                                                         |   9        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +              +                                                      |   7        |
      Cyst                                 |                                                                          |      1  4.0|
      Dilatation                           |                   3                                                      |      3  2.7|
      Inflammation, Chronic                |    4              2                                                      |      5  3.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +              +                                                         |   7        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +           +  +                                                         |   9        |
      Fibrosis                             |             3                                                            |      1  3.0|
      Inflammation, Chronic                |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +              +                                                         |   9        |
      Seminiferous Tubule, Atrophy         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +              +                                                         |   8        |
      Hyperplasia, Neutrophil              |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              A  +        +                                             |  13        |
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +              A  +        +                                             |  10        |
      Hemorrhage                           |                                                                          |      3  2.7|
      Hyperplasia, Lymphoid                |                   1                                                      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +     +                                             |  39        |
      Hematopoietic Cell Proliferation     |                                                                          |      4  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +              M                                                         |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3|                                            |            |
                                           | 9| 1| 9| 9| 2| 9| 2| 2| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M              M                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +              +                                                         |  20        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +                                                         |   9        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +  +        +                                             |  41        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Mineralization, Multifocal           |    1     2  2     1        1                                             |     37  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  A  +  +     +                                             |  48        |
      Leukocytosis                         |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                            2                                             |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Artery, Hypertrophy, Multifocal      |                                                                          |      1  2.0|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Lymphocyte             |          2                                                               |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +              +                                                         |   8        |
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +              A                                                         |   7        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3|                                            |            |
                                           | 9| 1| 9| 9| 2| 9| 2| 2| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    6250PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Lens, Cataract                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        A  +                                                      |  14        |
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Cortex, Cyst                         |       2                                                                  |      2  2.5|
      Cortex, Mineralization, Multifocal   | 2                                                                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +              +                                                         |   7        |
      Infiltration Cellular, Lymphocyte    |                4                                                         |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|             
                                           | 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |       2  2        3                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +        +  A  +  +  M     +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  M  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                     4                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +        +  A  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |             1     1                                                      |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Cytomegaly, Focal                    |                   2                                                      |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                    3                     |             
      Mitotic Alteration                   |                                                    2                     |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Portal, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |             1                                   1  1                 1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +  +                                                               |             
      Abscess                              |                                                                          |             
      Dysplasia                            |       3  2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|             
                                           | 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Mineralization,          |                                                                          |             
          Multifocal                       |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Capsule, Ectopic Tissue              |                                                                          |             
      Capsule, Hyperplasia, Multifocal     | 1     3  1  3  2  2        2        3        2  2  2  3  2        2  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                      2   |             
      Hypertrophy, Focal                   |       1  2                                   2        4  3           3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     M  M  M  +  +        +  M  M  +  +     M  +  M  M  M  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Cyst                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Focal  | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Serosa, Necrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                             +  +         |             
      Congestion                           |                                                                4         |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                               4                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +        +                       +  +  +     +|             
      Abscess                              |                            4                                      4      |             
      Cyst                                 |                            4        4                       3            |             
      Dilatation                           |                                                                1        4|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                             3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|             
                                           | 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Neutrophil              |                                                             2            |             
      Erythroid Cell, Depletion Cellular   |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                2                                                         |             
      Inguinal, Hyperplasia, Lymphoid      |                   3                                               3      |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                         2|             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mandibular, Hemorrhage               |       2                                                                  |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  M  +|             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
      Hemorrhage                           |       1                                            1  1                  |             
      Hyperplasia, Lymphoid                |       1           3                 1              2              2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                               2                             2            |             
      Dysplasia                            |                   3                                                      |             
      Hematopoietic Cell Proliferation     | 4              4                                   1                    3|             
      Hyperplasia, Lymphoid                |                                                 1                        |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  M  +        +  +  M  +  +     +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   | 2                             3                             4  4         |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M  M  M  M        M  M  M  M  M     M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                             3            |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                | 4                                                                        |             
      Prepuce, Inflammation, Acute         |                                                                          |             
      Prepuce, Ulcer                       |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|             
                                           | 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization, Multifocal           |          1     2  1                             3  2  2  3           1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +  +  +        +        +        +  +  +  +  +        +  M  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                       4                  |             
      Interstitium, Fibrosis               |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Degeneration, Hyaline        |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                             1            |             
      Respiratory Epithelium, Hyperplasia  |                                              1  1                    1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Atypical, Focal         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |             1                                   1                    1   |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Nephropathy, Chronic                 |                            1                                         1   |             
      Cortex, Cyst                         |          3                                                               |             
      Cortex, Mineralization, Multifocal   |                                                                          |             
      Pelvis, Fibrosis                     |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                             2            |             
      Renal Tubule, Degeneration, Focal    |                                                                          |             
      Renal Tubule, Dilatation             |                                                                2         |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                +         |             
      Inflammation, Acute                  |                                                                          |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Acute                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                             3  4         |             
      Infiltration Cellular, Lymphocyte    |                                     1  2                                 |             
      Inflammation, Acute                  |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|             
                                           | 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +  +  +     +  +  +  +  +  +  M     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     M  +  +  +     +  +  +     +  +  M  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                3        2           4  2     2     3                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Ulcer                                |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                            1        2  2                                 |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Cyst                                 |                                                          4               |             
      Cytomegaly, Focal                    |          2                                                               |             
      Fatty Change, Focal                  |                2                 2                                       |             
      Hematopoietic Cell Proliferation     |       1                                                                  |             
      Infarct                              |                                                                   3      |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis, Focal                      |                                                                   2      |             
      Bile Duct, Hyperplasia               |                                           2                              |             
      Portal, Fibrosis                     |                                           2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                          2               |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                     1  1                    1        1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                                    |             
      Abscess                              |                                     2                                    |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|             
                                           | 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Myocardium, Mineralization,          |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Capsule, Ectopic Tissue              |                                                    2                     |             
      Capsule, Hyperplasia, Multifocal     | 1     1     2        3     2     1     4  2  1  1  2     1  1     2  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Hyperplasia, Focal                   |                                                 2                    2   |             
      Hypertrophy, Focal                   |                                  1  2                       1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     M  M  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Hyperplasia, Focal                   |                                                             2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Hyperplasia                          |                                                 1        2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  M  +     +  M  +     +  +  +  M  M  M  +     +  M     M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  M  +     +  M  +     +  +  +  +  +  +  +     +  +     +  +  M|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Serosa, Necrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Congestion                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                                                       +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                         3|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic                | 4                                                                       3|             
                                            __________________________________________________________________________|             
   Prostate                                | +     M  +  +  +     M  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Inflammation, Chronic                |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|             
                                           | 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Mineralization, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Neutrophil              |       4                                                           2      |             
      Erythroid Cell, Depletion Cellular   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +  +  M     +  +  +  +  +  +  +     +  +     +  +  +|             
      Hyperplasia, Plasma Cell             |       3                                                                  |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |       4                                                                  |             
      Mandibular, Hemorrhage               |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |       4                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     M  +  +  +     +  +  M     +  +  +  +  +  +  +     +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |          2                             1           2                 3   |             
      Hyperplasia, Lymphoid                |                2                    2        2                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Dysplasia                            |                                                                          |             
      Hematopoietic Cell Proliferation     |       4     3                                               1     3      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     M  M  +  +     +  +  +     +  +  +  +  +  +  +     +  +     M  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M  M  +     M  M  M     M  M  M  M  M  M  M     M  M     M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Inflammation, Acute                  |       3                                                                  |             
      Inflammation, Chronic                |          3                                                        3      |             
      Ulcer                                |                                                                   4      |             
      Prepuce, Inflammation, Acute         |                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|             
                                           | 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12500PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization, Multifocal           |                            2           1  2                 2     2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +        M  +  +     +  +  +     +  +  +  +  +  +  M     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                              2                           |             
      Interstitium, Fibrosis               |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Mucosa, Degeneration, Hyaline        |                                        1        1                        |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                    1                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Hydronephrosis                       |                                           3                              |             
      Hyperplasia, Atypical, Focal         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                1        1  1           2     1  1                    1   |             
      Infiltration Cellular, Mixed Cell    |       1                                                                  |             
      Nephropathy, Chronic                 | 1           1              1                             1               |             
      Cortex, Cyst                         |                                                 3                        |             
      Cortex, Mineralization, Multifocal   |                            2                                             |             
      Pelvis, Fibrosis                     |                                                    2                     |             
      Pelvis, Inflammation, Acute          |                                           4                              |             
      Renal Tubule, Degeneration, Focal    |                                     1                             1      |             
      Renal Tubule, Dilatation             |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                           +                              |             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +  +  +     M  +  +  +  +  +  +     +  +     +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                 1                       1|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5|                                            |            |
                                           | 0| 0| 9| 1| 1| 5| 2| 1| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A                                                |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +                                                |  48        |
      Peyer's Patch, Hyperplasia, Lymphoid |       4  3                                                               |     11  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  M  +  +  A  +  +  +                                                |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +                                                |  48        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +                                                |  48        |
      Ulcer                                |                         3                                                |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |    1     1              4                                                |      8  1.6|
      Serosa, Inflammation, Chronic Active |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Cytomegaly, Focal                    |                                                                          |      2  2.0|
      Fatty Change, Focal                  |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                         3                                                |      2  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Portal, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                         3                                                |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  49        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       1              1                                                   |     10  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Serosa, Inflammation, Chronic Active |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5|                                            |            |
                                           | 0| 0| 9| 1| 1| 5| 2| 1| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Abscess                              |                                                                          |      1  2.0|
      Dysplasia                            |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +                                                            |   1        |
      Aorta, Inflammation, Chronic Active  |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Myocardium, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +                                                |  50        |
      Capsule, Ectopic Tissue              |                                                                          |      1  2.0|
      Capsule, Hyperplasia, Multifocal     | 1  1  1     2     1  1                                                   |     38  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
      Hypertrophy, Focal                   | 1        2  3                                                            |     12  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +                                                |  48        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  +  M  +  +                                                |  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +                                                |  44        |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  49        |
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +                                                |  50        |
      Serosa, Necrosis, Focal              |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                                         |   4        |
      Congestion                           |                                                                          |      1  4.0|
      Inflammation, Acute                  |                4                                                         |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5|                                            |            |
                                           | 0| 0| 9| 1| 1| 5| 2| 1| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +     +                                                            |  11        |
      Abscess                              |       4     4                                                            |      4  4.0|
      Cyst                                 |                                                                          |      4  3.5|
      Dilatation                           |                                                                          |      2  2.5|
      Inflammation, Chronic                | 3                                                                        |      3  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +                                                |  48        |
      Inflammation, Acute                  |                4                                                         |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +                                                |  50        |
      Inflammation, Chronic                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Mineralization, Focal                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hyperplasia                          |                      3                                                   |      1  3.0|
      Hyperplasia, Neutrophil              |             2  2                                                         |      5  2.4|
      Erythroid Cell, Depletion Cellular   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  A  +  +  +                                                |  47        |
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
      Inguinal, Hyperplasia, Lymphoid      | 3           4                                                            |      4  3.3|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  4.0|
      Mandibular, Hemorrhage               |                                                                          |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  A  +  +  +                                                |  45        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage                           |       2     3     1                                                      |     10  1.7|
      Hyperplasia, Lymphoid                |                      3                                                   |      9  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Depletion Lymphoid                   |                                                                          |      2  2.0|
      Dysplasia                            |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |       3     2  4        1                                                |     12  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +                                                |  45        |
      Depletion Lymphoid                   |          1     2        2                                                |      7  2.6|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5|                                            |            |
                                           | 0| 0| 9| 1| 1| 5| 2| 1| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M                                                |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Inflammation, Chronic                |                1                                                         |      3  2.3|
      Ulcer                                |                                                                          |      2  4.0|
      Prepuce, Inflammation, Acute         |                4                                                         |      1  4.0|
      Prepuce, Ulcer                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  49        |
      Mineralization, Multifocal           | 1  2              1  1  2                                                |     18  1.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +     +  +                                                   |  39        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  3.0|
      Interstitium, Fibrosis               |             3                                                            |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +                                                |  49        |
      Mucosa, Degeneration, Hyaline        |                   1  1                                                   |      4  1.0|
      Mucosa, Inflammation, Acute          |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                   2                                                      |      5  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Hyperplasia, Atypical, Focal         |                      2                                                   |      1  2.0|
      Infiltration Cellular, Lymphocyte    |    1  1           1                                                      |     13  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05706-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 13:29:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5|                                            |            |
                                           | 0| 0| 9| 1| 1| 5| 2| 1| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    12500PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  1.0|
      Nephropathy, Chronic                 |    1                                                                     |      7  1.0|
      Cortex, Cyst                         |                                                                          |      2  3.0|
      Cortex, Mineralization, Multifocal   |                                                                          |      1  2.0|
      Pelvis, Fibrosis                     |                                                                          |      1  2.0|
      Pelvis, Inflammation, Acute          |                2                                                         |      3  2.7|
      Renal Tubule, Degeneration, Focal    |                      2                                                   |      3  1.3|
      Renal Tubule, Dilatation             |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                +                                                         |   2        |
      Inflammation, Acute                  |                4                                                         |      1  4.0|
      Bulbourethral Gland, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +                                                |  49        |
      Dilatation                           |                                                                          |      2  3.5|
      Infiltration Cellular, Lymphocyte    | 1                 1                                                      |      6  1.2|
      Inflammation, Acute                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
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