TDMS Study 05706-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05706 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID TIME: 22:57:56
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60162
CONT: CAS: 81-11-8
PATHOLOGIST: M. STEDHAM S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05706 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID TIME: 22:57:56
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60162
CONT: CAS: 81-11-8
PATHOLOGIST: M. STEDHAM S. EUSTIS
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 45 53 70 131 321 337 568 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6250PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 11 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 209 279 439 605 607 628 696 711 714 |
| CENSORED DEATHS |
| 201 456 456 456 456 456 456 456 456 456 |
| 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12500PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 8 CENSORED DEATHS 10 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 22 22 65 130 131 438 576 645 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 95.0 93.3 93.3 90.0 90.0 90.0 90.0 88.0 88.0 88.0 |
| | |
| | |
|6250PPM | 100.0 100.0 98.3 96.6 96.6 94.9 94.9 92.9 88.7 82.5 |
| | |
| | |
|12500PPM | 95.0 91.7 91.7 91.7 91.7 90.0 90.0 88.0 85.9 85.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 6250PPM 12500PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 88.0% 82.5% 85.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.888 P=0.842 P=0.992 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 217.9 543.1 253.6 |
|NATURAL DEATHS (C) | (74.6) (63.3) (91.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 623.9 646.8 620.1 |
|(STANDARD ERROR) | (24.6) (18.5) (25.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 410 587 602 614 695 710 714 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6250PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 163 438 558 601 639 662 676 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12500PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 11 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 529 602 639 640 660 667 672 680 684 718 |
| 721 |
| CENSORED DEATHS |
| 387 456 456 456 456 456 456 456 456 456 |
| 456 |
| |
==================================================================================
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.3 98.3 98.3 94.3 92.3 86.3 |
| | |
| | |
|6250PPM | 100.0 98.3 98.3 98.3 98.3 96.7 96.7 92.6 88.6 86.6 |
| | |
| | |
|12500PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 95.9 89.8 77.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 6250PPM 12500PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.3% 86.6% 77.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.348 P=1.000 P=0.417 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 618.9 533.9 655.6 |
|NATURAL DEATHS (C) | (40.3) (68.9) (16.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 670.7 660.7 664.4 |
|(STANDARD ERROR) | (14.0) (16.2) (14.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
6250PPM = 2
12500PPM = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
|
|
| 11 2 2
98 +
|
|
| 3 1 1 2 2
96 +
|
P | 1 1 2 2
E |
R 94 +
C | 1 1
E |
N |
T 92 +
| 3 1 1 3
S | 2 2
U |
R 90 + 1 3 13
V |
I |
V | 2 2
A 88 + 13 3 1
L |
|
| 2 2
86 + 3 3
|
|
|
84 +
|
|
| 2 2
82 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
6250PPM = 2
12500PPM = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.0 +1 2 1 3
|
|
| 2 1 2 3 1 3
97.5 +
| 2 2
| 1 1
| 3 3
95.0 +
| 2 1 1
P |
E |
R 92.5 + 2 1 2 1
C | 3 3
E |
N | 2 2
T 90.0 + 33 1 1
|
S | 2 2
U |
R 87.5 +
V | 2 2
I | 1 1
V | 3 3
A 85.0 +
L |
|
|
82.5 +
| 3 3
|
|
80.0 +
|
|
|
77.5 + 3 3
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.