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TDMS Study 05706-02 Pathology Tables

NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 12:49:48




       Facility:  International Research and Development Corp.

       Chemical CAS #:  81-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|             
                                           | 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Angiectasis                          |                                  2                                       |             
      Congestion                           |                                                                          |             
      Cytologic Alterations                |                                                                          |             
      Cytologic Alterations, Multiple      | X  X  X                 X  X     X        X                 X            |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X  X           X                                X         |             
      Hyperplasia, Focal                   |                               3                          2              2|             
      Inflammation, Chronic                | 2              1                 2                                       |             
      Mitotic Alteration                   |       4                                                                  |             
      Necrosis, Multifocal                 |             2                                                            |             
      Bile Duct, Hyperplasia               |    1        2        2           1     2  1           2  2        2     2|             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                   2  3                 3              2           2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fat, Necrosis                        |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Acinus, Atrophy, Diffuse             |       3                                                                  |             
      Acinus, Atrophy, Focal               | 1           1                    1        1                 1     1     1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Atrophy, Focal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Inflammation, Acute                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Edema                                |                                                                2         |             
      Erosion                              |                                                                1         |             
      Inflammation, Acute                  |                1                                                         |             
      Mineralization                       |                                              4                           |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|             
                                           | 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                          +  +            |             
      Epithelium, Hyperplasia              |                                                          2  2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Cardiomyopathy                       | 1  1           1     1  1  2     1        1           1  2        1     1|             
      Mineralization                       |                                              3                           |             
      Atrium, Thrombosis                   |                2                       2                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Congestion                           |                                                                          |             
      Necrosis, Focal                      |             2     2                                                      |             
      Vacuolization Cytoplasmic, Focal     |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hyperplasia                          | 1           2                    1        2                              |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Angiectasis           |             1  2     2  2  3     3  1  2  3                              |             
      Pars Distalis, Cyst                  |                         3                                1  3     2     2|             
      Pars Distalis, Hyperplasia           |                1              2                             2            |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                        1                 2  2           2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +     +  +  +  +  +  +  M  +  M  +  +  +        +  +  +  +  +     +|             
      Dilatation                           |                            2                                             |             
      Inflammation, Acute                  |       2                                                  2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Cyst                                 |    2           2           1     1                          2            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hemorrhage                           |                                                       3                  |             
      Inflammation, Chronic                | 1                                                                        |             
      Endometrium, Hyperplasia, Cystic     |                      1     1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|             
                                           | 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +                                                                        |             
      Inflammation, Acute                  | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Fibrosis                             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Bronchial, Hemorrhage                |                      2                                                   |             
      Iliac, Cyst                          |                               2                                          |             
      Mandibular, Cyst                     |                1                                                         |             
      Mandibular, Hemorrhage               |    1                 2                    2                 2            |             
      Mediastinal, Hemorrhage              | 1                                                           2            |             
      Mediastinal, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hemorrhage                           |                      2                                      1            |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Congestion                           |                2                                                         |             
      Fibrosis, Focal                      |                                                          2               |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Necrosis, Focal                      |                   2                                                      |             
      Pigmentation                         |                                           3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  M  +  +  +  +        +  +  +  +  +     +|             
      Cyst                                 |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Dilatation                           |                            2  2                                          |             
      Hyperplasia                          |             2                 2           3                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Edema           |    3                                                                     |             
      Subcutaneous Tissue, Thrombosis,     |                                                                          |             
           Multiple                        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|             
                                           | 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +        +  +  +     +  +  +  +        +           +  +  +           +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Foreign Body                         |                                  1                                       |             
      Hemorrhage                           |                   1                       1                 1            |             
      Hyperplasia, Adenomatous             |                            1                                             |             
      Infiltration Cellular, Histiocyte    | 1              1                                                  1      |             
      Thrombosis                           |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                  2                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Nasolacrimal Duct, Fungus            |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Sinus, Foreign Body                  |                                  2                                       |             
      Sinus, Fungus                        |                   2                                                      |             
      Sinus, Inflammation, Acute           |                   3              2                       2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +     +                                                |             
      Iris, Inflammation, Chronic          |                         2                                                |             
      Lens Capsule, Cataract               |    2                                                                     |             
      Retina, Atrophy                      |    2                                                                     |             
      Sclera, Metaplasia, Osseous          |    1                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  2        3  2     2  2  1  1  1     1  1  4        1  2  2  1  1     1|             
      Pigmentation                         |                      3                                                   |             
      Pelvis, Dilatation                   |                               4                                          |             
      Pelvis, Inflammation, Acute          |                2                                                         |             
      Pelvis, Inflammation, Subacute       |                                                                          |             
      Pelvis, Mineralization               | 1                       1        1        1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Inflammation, Acute                  |                2                                                         |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|             
                                           | 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Parasite Metazoan                    |       X                    X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                              1                    2      |             
      Cytologic Alterations                |    X                                                                     |             
      Cytologic Alterations, Multiple      |          X        X  X  X        X     X     X     X     X           X   |             
      Hemorrhage                           |                   1                                                      |             
      Hepatodiaphragmatic Nodule           | X  X                       X           X     X  X  X     X     X  X      |             
      Hyperplasia, Focal                   |                                                                   2      |             
      Inflammation, Chronic                |    1           2     1  1              2     1  1                        |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Bile Duct, Hyperplasia               | 2     1  1        1  1  1  1  2  1                                       |             
      Centrilobular, Necrosis              |                                                                         3|             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Fat, Necrosis                        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               |    1              2        1     1              1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Atrophy, Focal                       |                                              1                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Inflammation, Acute                  |                               1                 1                        |             
      Epithelium, Hyperplasia              |                3                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |             1                 1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|             
                                           | 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Cardiomyopathy                       |          1     1     2     1                    1  1              1     2|             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Congestion                           | 2  1                                                                     |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     | 1  2     2                                                     2        1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Hyperplasia                          |                      1     1                 1                           |             
      Infiltration Cellular, Lymphocyte    |                2                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Hemorrhage                           | 2                                                                        |             
      Pars Distalis, Angiectasis           |                                                          2     2  3      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                   2  2                       1  2                 3      |             
      Pars Nervosa, Cyst                   |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Cyst                                 |                2                                                         |             
      C-Cell, Hyperplasia                  |       1  1                    1                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  M  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |    2                       2     2                                   1   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Cyst                                 | 2                             2                                   1      |             
      Inflammation, Chronic                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                            1                 2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|             
                                           | 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Bronchial, Hemorrhage                |                                                                          |             
      Iliac, Cyst                          |                                                                          |             
      Mandibular, Cyst                     |                3                       1                                 |             
      Mandibular, Hemorrhage               |                         1                                                |             
      Mediastinal, Hemorrhage              |                2     1                             2     1               |             
      Mediastinal, Pigmentation            |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Hemorrhage                           |          1              1                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation                         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Dilatation                           |    3                                               2              2  2   |             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Cyst                                 |                                                          2               |             
      Subcutaneous Tissue, Abscess         |          2                                                               |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Thrombosis,     |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Thrombosis                           |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|             
                                           | 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +        +  +  +  +           +     +  +  +     +     +  +      |             
      Inflammation, Chronic                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           | 1                 1        1  2        1  2  1  1                        |             
      Hyperplasia, Adenomatous             |                                        1                                 |             
      Infiltration Cellular, Histiocyte    |          1           1  1                    1                           |             
      Thrombosis                           |                2                                                         |             
      Interstitium, Inflammation, Chronic  |    1                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +     +     +  +  +  +|             
      Nasolacrimal Duct, Fungus            |                                                                2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                2         |             
      Sinus, Foreign Body                  |                                                                          |             
      Sinus, Fungus                        |                                                                          |             
      Sinus, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Iris, Inflammation, Chronic          |                                                                          |             
      Lens Capsule, Cataract               |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 1  3  1  1  1     1  2  2  2  1  2     1  1  1  1  2     1     2  2  1  1|             
      Pigmentation                         |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Pelvis, Inflammation, Subacute       |          3                                                               |             
      Pelvis, Mineralization               |                1  1                             1        1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 7| 6| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5|                                            |            |
                                           | 4| 6| 6| 4| 6| 4| 4| 4| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +        +     +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +     +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                      X                                                   |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +        +     +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +     +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      2  1.5|
      Cytologic Alterations                |                                                                          |      1     |
      Cytologic Alterations, Multiple      |          X     X     X  X  X                                             |     23     |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           | X                    X                                                   |     16     |
      Hyperplasia, Focal                   | 2                                                                        |      5  2.2|
      Inflammation, Chronic                |          1     1     1                                                   |     13  1.3|
      Mitotic Alteration                   |                                                                          |      1  4.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |     19  1.5|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +     +  +  +  +  +                                             |  49        |
      Acinus, Atrophy, Diffuse             |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               |                   2                                                      |     13  1.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +        +     +  +  +  +  +                                             |  49        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +        +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +     +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Epithelium, Hyperplasia              |                            1                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +     +  +  +  +  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 7| 6| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5|                                            |            |
                                           | 4| 6| 6| 4| 6| 4| 4| 4| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +     +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       | 1        2     1     1  1                                                |     25  1.2|
      Mineralization                       |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +        +     +  +  +  +  +                                             |  49        |
      Congestion                           |                                                                          |      2  1.5|
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      6  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +        +     +  +  +  +  +                                             |  49        |
      Hyperplasia                          | 2        1                                                               |      9  1.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +     +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +     +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           | 2              2        3                                                |     15  2.2|
      Pars Distalis, Cyst                  |                      2     2                                             |      7  2.1|
      Pars Distalis, Hyperplasia           |                3                                                         |      9  2.0|
      Pars Nervosa, Cyst                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +     +  +  +  +  +                                             |  49        |
      Cyst                                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |                         1                                                |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 7| 6| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5|                                            |            |
                                           | 4| 6| 6| 4| 6| 4| 4| 4| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +        +     +  +  +  +  +                                             |  47        |
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      6  1.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +        +     +  +  +  +  +                                             |  50        |
      Cyst                                 | 1                       1                                                |     10  1.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +     +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Endometrium, Hyperplasia, Cystic     |                1                                                         |      5  1.2|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +     +  +  +  +  +                                             |  49        |
      Fibrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +     +  +  +  +  +                                             |  50        |
      Bronchial, Hemorrhage                |                                                                          |      1  2.0|
      Iliac, Cyst                          |                                                                          |      1  2.0|
      Mandibular, Cyst                     |                1                                                         |      4  1.5|
      Mandibular, Hemorrhage               |                                                                          |      5  1.6|
      Mediastinal, Hemorrhage              |                2                                                         |      7  1.6|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +     +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      4  1.3|
      Hyperplasia, Lymphoid                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +     +  +  +  +  +                                             |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +     +  +  +  +  +                                             |  48        |
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +     +  +  +  +  +                                             |  50        |
      Dilatation                           |                                                                          |      6  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 7| 6| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5|                                            |            |
                                           | 4| 6| 6| 4| 6| 4| 4| 4| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +     +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  2.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Thrombosis,     |                                                                          |            |
           Multiple                        |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +     +  +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +     +  +  +  +  +                                             |  50        |
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +        +     +     +  +                                                |  33        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +     +  +  +  +  +                                             |  50        |
      Foreign Body                         |                                                                          |      1  1.0|
      Hemorrhage                           |                1                                                         |     12  1.2|
      Hyperplasia, Adenomatous             |                                                                          |      2  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      7  1.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                         2                                                |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +     +  +  +  +  +                                             |  49        |
      Nasolacrimal Duct, Fungus            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Sinus, Foreign Body                  |                                                                          |      1  2.0|
      Sinus, Fungus                        |                                                                          |      1  2.0|
      Sinus, Inflammation, Acute           |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Iris, Inflammation, Chronic          |                                                                          |      1  2.0|
      Lens Capsule, Cataract               |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 7| 6| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5|                                            |            |
                                           | 4| 6| 6| 4| 6| 4| 4| 4| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Sclera, Metaplasia, Osseous          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +     +  +  +  +  +                                             |  50        |
      Cyst                                 |                      2                                                   |      1  2.0|
      Nephropathy                          | 3        2     2  2  2  3  1                                             |     46  1.6|
      Pigmentation                         |                                                                          |      1  3.0|
      Pelvis, Dilatation                   |                                                                          |      1  4.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  2.0|
      Pelvis, Inflammation, Subacute       |                                                                          |      1  3.0|
      Pelvis, Mineralization               |                                                                          |      8  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +     +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|             
                             DAY ON TEST   | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|             
                                           | 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +        +                             +   |             
      Mineralization                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +        +                             +   |             
      Mineralization                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +        +  +  +  +  +  +  +  +  +     +  +     +  +        +  +|             
      Angiectasis                          |                                                                         2|             
      Congestion                           |                                                                          |             
      Cytologic Alterations                |          X        X  X                                                   |             
      Cytologic Alterations, Multiple      |                         X  X        X                    X  X            |             
      Fibrosis, Focal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           |                         X        X        X        X     X               |             
      Hyperplasia, Focal                   |                                     2     2                              |             
      Hyperplasia, Multifocal              |                                        2                                 |             
      Inflammation, Chronic                |                   1  2     1     1                          1            |             
      Vacuolization Cytoplasmic            |                                                                      1   |             
      Bile Duct, Hyperplasia               |    1                                   1        2  2                    2|             
      Centrilobular, Necrosis              | 3                                                                        |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Fat, Necrosis                        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +        +                             +   |             
      Acinus, Atrophy, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +        +                             +   |             
      Inflammation, Chronic                |                                                                      2   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +        +                             +   |             
      Erosion                              |                                                                          |             
      Mineralization                       |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                                          |             
      Aorta, Mineralization                |                               2                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +        +                             +   |             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|             
                             DAY ON TEST   | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|             
                                           | 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
      Amyloid Deposition                   |                            3                                             |             
      Hemorrhage                           |                            2                                             |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis, Focal                      | 3                                                                        |             
      Vacuolization Cytoplasmic, Focal     |                                  2        2  1                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
      Hyperplasia                          |          2        1     1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +        +                             +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +        M                             +   |             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +        +  +  +  +  +  +  +  +  +  +        +  +           +  +|             
      Pars Distalis, Angiectasis           |                   2        2        4                 3                 2|             
      Pars Distalis, Cyst                  |                   2                                                      |             
      Pars Distalis, Hyperplasia           | 1                          2        2                                2   |             
      Pars Distalis, Pigmentation          |                         1                                                |             
      Pars Nervosa, Ectopic Tissue         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +        +                             +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +                             +        +                             +  +|             
      Inflammation, Acute                  |                                                                         2|             
                                            __________________________________________________________________________|             
   Ovary                                   |                               +        +                             +   |             
      Mineralization                       |                               1                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +                          +        +              +  +           +  +|             
      Cervix, Inflammation, Acute          |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                       2                 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +        +                             +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +              +           +  +  +  +     +     +     +  +        +  +|             
      Iliac, Cyst                          |    2                                                                     |             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         | 2                                                                        |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hemorrhage              |                                  3  2              2        3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|             
                             DAY ON TEST   | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|             
                                           | 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Prefemoral, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +        +                             +   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +                 +  +     +        +     +           +           +  +|             
      Fibrosis, Focal                      |                                                                         2|             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Hemorrhage                           |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation                         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +           +  +|             
      Dilatation                           |                                  1                                       |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                               +        +                             +   |             
      Osteoporosis                         |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +                    +     +  +  +  +  +  +  +              +   |             
      Hemorrhage                           |                                           1     2     1                  |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                       1                  |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +        +                             +   |             
      Metaplasia, Squamous                 |                               2                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Sinus, Fungus                        |                                                                      2   |             
      Sinus, Inflammation, Acute           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                             +                          +            |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Lens Capsule, Cataract               |    4                             2                          2            |             
      Retina, Atrophy                      |    4                             3                          2            |             
      Sclera, Metaplasia, Osseous          |                                                             2            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|             
                             DAY ON TEST   | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|             
                                           | 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
      Fibrosis, Focal                      |                                                                      2   |             
      Nephropathy                          |    1     4        2  2  2  2  4  1  2  1  2     2     1  1  2        1  2|             
      Pigmentation                         |                                              2     1                     |             
      Artery, Inflammation, Chronic        |                                                             2            |             
      Pelvis, Inflammation, Acute          |                                                                      2   |             
      Pelvis, Mineralization               |          1           1           1  1  1  1  1  1  1  1              1   |             
      Pelvis, Epithelium, Hyperplasia      |                                                                      2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +        +                             +   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|             
                             DAY ON TEST   | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|             
                                           | 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +                       +  +                          +   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +                       +  +                          +   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +           +  +  +  +  +  +  +  +  +  +     +     +     +     +  +   |             
      Angiectasis                          |                                                                          |             
      Congestion                           |                         2                                   2            |             
      Cytologic Alterations                |                                                                          |             
      Cytologic Alterations, Multiple      |                            X  X                             X     X      |             
      Fibrosis, Focal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                             X                 X      |             
      Hyperplasia, Focal                   |                                     2                                    |             
      Hyperplasia, Multifocal              |                                                       3                  |             
      Inflammation, Chronic                |                1                                                         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               |                   1        2           1        2           2     2  1   |             
      Centrilobular, Necrosis              |                                  3                                       |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |    3                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +                       +  +                          +   |             
      Acinus, Atrophy, Focal               |                1                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +                 +     +  +              +           +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +                 +     +  +              +           +   |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +                 +     +  +              +           +   |             
      Erosion                              |                                        2  2                              |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +                       +  +                          +   |             
      Cardiomyopathy                       |                                        1  1                          1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|             
                             DAY ON TEST   | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|             
                                           | 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Amyloid Deposition                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis, Focal                      |                      1                                                   |             
      Vacuolization Cytoplasmic, Focal     |    2                                            2        2  2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Hyperplasia                          |                                                                   1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +                       +  +                          +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +                       +  +                          +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +     +  +           +  +  +  +  +     +  +  +     +     +  +   |             
      Pars Distalis, Angiectasis           | 3                             4                 2                        |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                 2                        |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Nervosa, Ectopic Tissue         |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +           M  +                    +  +              +           +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +                       +  +                          +   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |          +     +  +  +     +  +        +  +        +  +              +   |             
      Cervix, Inflammation, Acute          |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +                       +  +                          +   |             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +  +  +     +        +  +  +     +  +     +           +   |             
      Iliac, Cyst                          |                                                                          |             
      Iliac, Hemorrhage                    |                                                    2                     |             
      Iliac, Hyperplasia, Lymphoid         |                            2                                             |             
      Inguinal, Hyperplasia, Lymphoid      |                2                                                         |             
      Mediastinal, Hemorrhage              |                                     2           2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|             
                             DAY ON TEST   | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|             
                                           | 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Prefemoral, Hyperplasia, Lymphoid    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +                       +        +                    +   |             
      Hemorrhage                           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +     +  +  +  +        +     +  +                          +   |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |    3           2                                                         |             
      Hemorrhage                           |    1                                                                     |             
      Necrosis, Focal                      |                                        2                                 |             
      Pigmentation                         |          2                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +           +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Dilatation                           |                2                                                         |             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Skin                                    |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +                       +  +                          +   |             
      Osteoporosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +  +     +  +  +        +  +     +  +  +     +     +  +   |             
      Hemorrhage                           |                         2  1  1                 1  2  1     2            |             
      Hyperplasia, Adenomatous             |                                        1        2                        |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +                       +  +                          +   |             
      Metaplasia, Squamous                 |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                      1   |             
      Sinus, Fungus                        |                                                                          |             
      Sinus, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +                       +  +                          +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Lens Capsule, Cataract               |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|             
                             DAY ON TEST   | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|             
                                           | 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12500PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy                          | 1  2     2     1  1  1  2  2  3  3  2  2  1  2  2  2  2  1  2     2  1   |             
      Pigmentation                         |    1                                                                     |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Pelvis, Mineralization               | 1  1           1     1  1  1  1  1           1  1  1     1  1     1  1   |             
      Pelvis, Epithelium, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +              +                       +  +                          +   |             
      Hemorrhage                           | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 6| 2| 2| 3| 3| 2| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |   8        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |   8        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +  +  +  +  +  +  +                                             |  42        |
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           |          2                                                               |      3  2.0|
      Cytologic Alterations                |                                                                          |      3     |
      Cytologic Alterations, Multiple      |             X  X     X                                                   |     12     |
      Fibrosis, Focal                      |                1                                                         |      1  1.0|
      Hepatodiaphragmatic Nodule           |                X  X                                                      |     10     |
      Hyperplasia, Focal                   |                   1                                                      |      4  1.8|
      Hyperplasia, Multifocal              |                                                                          |      2  2.5|
      Inflammation, Chronic                | 2        2  2     2  2     2                                             |     12  1.6|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |             1           2                                                |     14  1.6|
      Centrilobular, Necrosis              |                                                                          |      2  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   2        |
      Fat, Necrosis                        |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |   8        |
      Acinus, Atrophy, Focal               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                                                                        |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  10        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  10        |
      Erosion                              |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 6| 2| 2| 3| 3| 2| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |   8        |
      Cardiomyopathy                       | 1                                                                        |      4  1.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +                                             |  50        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                         2                                                |      1  2.0|
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |                            2                                             |      8  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                         2                                                |      5  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |   7        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +        +  +  +                                             |  37        |
      Pars Distalis, Angiectasis           |             3                                                            |      9  2.8|
      Pars Distalis, Cyst                  |          3                                                               |      2  2.5|
      Pars Distalis, Hyperplasia           |                      2                                                   |      6  1.8|
      Pars Distalis, Pigmentation          |                                                                          |      1  1.0|
      Pars Nervosa, Ectopic Tissue         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +              +                                                         |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                 +                                                      |  13        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |   8        |
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                    +     +                                             |  22        |
      Cervix, Inflammation, Acute          |                            4                                             |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                      2                                                   |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 6| 2| 2| 3| 3| 2| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |   8        |
      Hyperplasia                          | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                 +                                                      |  27        |
      Iliac, Cyst                          |                                                                          |      1  2.0|
      Iliac, Hemorrhage                    |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      2  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                   2                                                      |      7  2.3|
      Prefemoral, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   8        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                       +                                                |  22        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Hemorrhage                           |                                                                          |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +  +  +  +  +  +  +                                             |  47        |
      Dilatation                           |             2           3                                                |      4  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |   8        |
      Osteoporosis                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +     +                                                      |  29        |
      Hemorrhage                           |       1     2     1                                                      |     13  1.4|
      Hyperplasia, Adenomatous             |          2                                                               |      3  1.7|
      Infiltration Cellular, Histiocyte    |       1                                                                  |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 6| 2| 2| 3| 3| 2| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    12500PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |   8        |
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
      Sinus, Fungus                        |                                                                          |      1  2.0|
      Sinus, Inflammation, Acute           | 1                                                                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +              +                                                         |   5        |
      Cornea, Inflammation, Chronic        |                2                                                         |      1  2.0|
      Lens Capsule, Cataract               | 2              2                                                         |      5  2.4|
      Retina, Atrophy                      | 4              4                                                         |      5  3.4|
      Sclera, Metaplasia, Osseous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Nephropathy                          | 1     1  2  2  3  1  2  2  2                                             |     47  1.8|
      Pigmentation                         |                                                                          |      3  1.3|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  2.0|
      Pelvis, Mineralization               |          1  1     1        1                                             |     30  1.0|
      Pelvis, Epithelium, Hyperplasia      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |   9        |
      Hemorrhage                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|             
                                           | 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                        2     2   |             
      Cytologic Alterations                |                      X     X                                             |             
      Cytologic Alterations, Multiple      |                X              X                       X        X  X  X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |       1                                                                  |             
      Hepatodiaphragmatic Nodule           |                   X                       X              X               |             
      Hyperplasia, Focal                   |          3                                      4                       2|             
      Inflammation, Chronic                |       2        1        1  1                                             |             
      Pigmentation                         |                                                                          |             
      Thrombosis                           |                                                 3                        |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               |                1        1  1                    2     2     1        1  2|             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                   4                    3                 2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +        +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Fat, Necrosis                        |                                                       3        2         |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy, Focal               |       1              1  1              1  2     2              2  1      |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Artery, Inflammation, Chronic        |                               2                                          |             
      Artery, Inflammation, Subacute       |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                          +               |             
      Palate, Inflammation, Acute          |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                   2                                                      |             
      Ulcer                                |                                                          4               |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|             
                                           | 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                 1                        |             
      Inflammation, Acute                  |                   3                                                      |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Inflammation, Chronic Active         |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
      Artery, Inflammation, Chronic        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1        1           2     1  1                 1  1     2  1     1|             
      Atrium, Thrombosis                   |                   2                             3                        |             
      Myocardium, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |    2                    3        2  2                 1           2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 1                       2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  M     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2  3        2  3  3  3  3                          2           3      |             
      Pars Distalis, Cyst                  |                                                 2              1     2   |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hyperplasia           |       3                                                              2   |             
      Pars Distalis, Infarct               |                                                                          |             
      Pars Nervosa, Ectopic Tissue         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  M     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1                       2  2                          1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +     M  +  M  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|             
                                           | 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                       1                  |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                                                                      3   |             
      Endometrium, Hyperplasia, Cystic     |                      1                                            1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                         +        +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Axillary, Hemorrhage                 |                                                                          |             
      Axillary, Hyperplasia, Lymphoid      |                                  3                                       |             
      Lymphocyte, Mandibular, Necrosis     |                                                                         2|             
      Mandibular, Cyst                     |                                           2                              |             
      Mandibular, Hemorrhage               |                                        1                                 |             
      Mediastinal, Hemorrhage              |    1                                   2              2              2   |             
      Mediastinal, Pigmentation            |                      2                                                   |             
      Mediastinal, Lymphocyte, Necrosis    |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Hemorrhage                           |                2                                                     2   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                     1                                    |             
      Hematopoietic Cell Proliferation     |                                        2                                 |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Pigmentation                         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Dilatation                           |          2                                                               |             
      Hyperplasia                          |          2                                                     2        2|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Abscess         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|             
                                           | 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +        +  +  +  +  +  +        +  +     +     +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   1      |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Interstitium, Inflammation, Chronic  |       1        1              1     1                                1   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Sinus, Fungus                        |                         2                                                |             
      Sinus, Inflammation, Acute           |                         2                                                |             
      Turbinate, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Lens Capsule, Cataract               |                         4                                                |             
      Retina, Atrophy                      |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                         3|             
      Nephropathy                          |    2  2  1     2  1  1  1  2  1     1  1  1     1     1  4     1  1  2  1|             
      Pigmentation                         |                                                 2                 1      |             
      Pelvis, Mineralization               |    1  2  1        1  1  1  1  1  1     1  1     1     1     1  2  1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|             
                                           | 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    25000PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |                                                                      2  2|             
      Cytologic Alterations                |                                                                          |             
      Cytologic Alterations, Multiple      | X  X  X        X     X                             X     X        X      |             
      Hematopoietic Cell Proliferation     |                                                             1            |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X                          X                             X|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                      1                                   1           1  1|             
      Pigmentation                         |                            2                                             |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                         1|             
      Bile Duct, Hyperplasia               |       1              1                    1  2  2                        |             
      Centrilobular, Necrosis              |                            3                                             |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy, Focal               | 1  1           2     1           1              1           2            |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Artery, Inflammation, Chronic        |                2                                                         |             
      Artery, Inflammation, Subacute       |                                                          2               |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Cyst                                 |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                         2              2     1                           |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|             
                                           | 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    25000PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                        2     2                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Cardiomyopathy                       | 1  1  1        1     2  2                 1              1        1  1  1|             
      Atrium, Thrombosis                   |                            3                 2                           |             
      Myocardium, Necrosis                 |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Amyloid Deposition                   | 3                                                                        |             
      Hyperplasia, Focal                   |                                                 2                        |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     | 2                                         1                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Hyperplasia                          | 2                          1                                            1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Pars Distalis, Angiectasis           |    3                             3     3           2                 2   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hyperplasia           |                2           2                 2           1        1     1|             
      Pars Distalis, Infarct               |                                                 4                        |             
      Pars Nervosa, Ectopic Tissue         |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      C-Cell, Hyperplasia                  |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +        +     +  +  +     +     +  M  +  +  +  +  +  M     +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|             
                                           | 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    25000PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                  3                                2      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |                                  2                                       |             
      Fibrosis                             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |       1                                            2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Fibrosis                             |                            2                                             |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Axillary, Hemorrhage                 |                                                          2               |             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Lymphocyte, Mandibular, Necrosis     |                                                                          |             
      Mandibular, Cyst                     |                                                                          |             
      Mandibular, Hemorrhage               |       1                                1                                 |             
      Mediastinal, Hemorrhage              |       1                    2              1              2           1   |             
      Mediastinal, Pigmentation            |                                                                          |             
      Mediastinal, Lymphocyte, Necrosis    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  M     +  +  +|             
      Hemorrhage                           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Fibrosis, Focal                      |                                                          2               |             
      Hematopoietic Cell Proliferation     |                                                             3            |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +     +  +  +     +     +  +  +  +  +  M  +  +     +  +  +|             
      Cyst                                 |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Subcutaneous Tissue, Abscess         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|             
                                           | 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    25000PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +        +     +     +     +     +  +        +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                1                                                  1      |             
      Hyperplasia, Adenomatous             |                                                                         2|             
      Infiltration Cellular, Histiocyte    | 1                                                                        |             
      Interstitium, Inflammation, Chronic  |                                                                      1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                        3                                 |             
      Sinus, Fungus                        |                                                                          |             
      Sinus, Inflammation, Acute           |                                                                          |             
      Turbinate, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens Capsule, Cataract               |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                2                                                         |             
      Nephropathy                          | 3  1  1        1     2  1  2     1     2  2  1  1  1  1  1  1     1  1  2|             
      Pigmentation                         |                                                                          |             
      Pelvis, Mineralization               | 1  1  1        1     1     1     1     1     1  1  1        1     1     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +     +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 2| 8| 2| 2| 3| 3| 3| 2| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                         1  2                                             |      7  1.9|
      Cytologic Alterations                |       X                                                                  |      3     |
      Cytologic Alterations, Multiple      | X        X  X  X  X  X  X  X                                             |     22     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |          X        X                                                      |      8     |
      Hyperplasia, Focal                   |                         2                                                |      4  2.8|
      Inflammation, Chronic                | 2           1     1  2  1                                                |     13  1.2|
      Pigmentation                         |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |       1                 1  1                                             |     16  1.3|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                1                                                         |      1  1.0|
      Acinus, Atrophy, Focal               | 2  1     1     1  1  1  1  1                                             |     23  1.3|
      Acinus, Hyperplasia, Focal           |                      2                                                   |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      2  2.0|
      Artery, Inflammation, Subacute       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Inflammation, Acute          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 2| 8| 2| 2| 3| 3| 3| 2| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      4  2.3|
      Epithelium, Hyperplasia              |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       | 1     2  1           1  1  1                                             |     28  1.2|
      Atrium, Thrombosis                   |                                                                          |      4  2.5|
      Myocardium, Necrosis                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Necrosis, Focal                      |    2                                                                     |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                      1                                                   |      9  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia                          |             1        1                                                   |      7  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |          1                                                               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Pars Distalis, Angiectasis           |                      2                                                   |     15  2.6|
      Pars Distalis, Cyst                  |                                                                          |      3  1.7|
      Pars Distalis, Cyst, Multiple        |          X                                                               |      1     |
      Pars Distalis, Hyperplasia           |                2                                                         |      9  1.8|
      Pars Distalis, Infarct               |                                                                          |      1  4.0|
      Pars Nervosa, Ectopic Tissue         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 2| 8| 2| 2| 3| 3| 3| 2| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                                                                          |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Hyperplasia                          |                   2                                                      |      1  2.0|
      Inflammation, Acute                  |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Axillary, Hemorrhage                 |                                                                          |      1  2.0|
      Axillary, Hyperplasia, Lymphoid      |                      2                                                   |      2  2.5|
      Lymphocyte, Mandibular, Necrosis     |                                                                          |      1  2.0|
      Mandibular, Cyst                     |                                                                          |      1  2.0|
      Mandibular, Hemorrhage               |                   1                                                      |      4  1.0|
      Mediastinal, Hemorrhage              | 2        1     2  1     2                                                |     14  1.6|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
      Mediastinal, Lymphocyte, Necrosis    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hemorrhage                           |                2                                                         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis, Focal                      |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Inflammation, Focal, Granulomatous   | 3                                                                        |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Cyst                                 |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 2| 8| 2| 2| 3| 3| 3| 2| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Dilatation                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Subcutaneous Tissue, Abscess         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +  +  +     +  +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |          1                                                               |      4  1.0|
      Hyperplasia, Adenomatous             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic  |    1        1     1     1                                                |     10  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
      Sinus, Fungus                        |                                                                          |      1  2.0|
      Sinus, Inflammation, Acute           |                                                                          |      1  2.0|
      Turbinate, Inflammation, Chronic     |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   2        |
      Lens Capsule, Cataract               | 3                                                                        |      2  3.5|
      Retina, Atrophy                      | 3                                                                        |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |       1                                                                  |      3  2.0|
      Nephropathy                          | 2     2  2  2  1  1  1  2  2                                             |     47  1.4|
      Pigmentation                         |                      2                                                   |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 2| 8| 2| 2| 3| 3| 3| 2| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    25000PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pelvis, Mineralization               | 1  2           1  1  2  1  1                                             |     37  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|             
                                           | 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +     A  A  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +     A  A  +  +     +  +  +  +  +  +  +  +  +   |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +     A  A  +  +     +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |             X  X                                   X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +     A  A  +  +     +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                2                                                         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |       1                                                                  |             
      Congestion                           |                                                                2         |             
      Cyst                                 |          2                                                               |             
      Cytologic Alterations                | X     X     X                                                            |             
      Cytologic Alterations, Multiple      |    X                    X              X                                 |             
      Fibrosis, Focal                      |                                                 2                        |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X           X  X                          X                       X   |             
      Hyperplasia, Focal                   |                                                    2              2      |             
      Hyperplasia, Nodular                 |                2                                                         |             
      Vacuolization Cytoplasmic, Diffuse   |                                                          4               |             
      Bile Duct, Hyperplasia               | 1  2  1  1  1  3        2           2  2        2  1  2     2  1  2      |             
      Centrilobular, Degeneration          |          2                                                               |             
      Centrilobular, Necrosis              |                                                    2                     |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Periportal, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                     +      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             2                                                            |             
      Fat, Inflammation, Acute             |                                                                   1      |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Acinus, Atrophy, Focal               |             1                                            1     1         |             
      Artery, Inflammation, Chronic        |                                                 4                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|             
                                           | 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Acute                  |                                     2                                    |             
      Inflammation, Chronic                |                                                          2               |             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Erosion                              |                1  1                                1     2               |             
      Mineralization                       |                                              2                           |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
      Aorta, Inflammation, Chronic         |                                                 2                        |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy                       | 2     2  1  2  1        1     2  2  1  2     2  1  1  1     1  2  1      |             
      Atrium, Thrombosis                   |                                              2                           |             
      Epicardium, Fibrosis, Focal          |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |          2                                                               |             
      Hematopoietic Cell Proliferation     |                                        1                                 |             
      Hyperplasia                          |                         2                                                |             
      Thrombosis                           |                                        2                                 |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          | 1        2                             1           1     1        1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                              2                 1         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       1                                                           1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |    1     1                                                           1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|             
                                           | 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                       3                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                   2     1           1  4           2           1         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Focal                   | 1     1           2     1                                                |             
      Inflammation, Acute                  |       1  1  1                                2        2              2   |             
      Inflammation, Chronic                |                               3                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Atrophy                              | 1  2  2  2  2           2           2        1  2                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |    3  2  2        2                    2                 2               |             
      Interstitial Cell, Hyperplasia       |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                   2                    4                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inguinal, Cyst                       |       3                                                                  |             
      Inguinal, Hyperplasia, Lymphoid      |       2  2                                                               |             
      Mandibular, Cyst                     | 2     2     1                                                            |             
      Mediastinal, Cyst                    |                                                                          |             
      Mediastinal, Hemorrhage              |             1                                1  2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Congestion                           | 2                                                                        |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                        3           2                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Focal, Granulomatous   | 2                                                                        |             
      Necrosis                             |                                                                   2  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|             
                                           | 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Edema                                |                                                                          |             
      Inflammation, Acute                  |                                     2  4                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperostosis                         |                                                                          |             
      Osteomalacia                         |                                                                          |             
      Tarsal, Inflammation, Chronic Active |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                                                      3   |             
      Thrombosis, Multiple                 |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +        +                    +  +                        |             
      Inflammation, Subacute               |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                2         |             
      Hyperplasia, Adenomatous             |    2        2                                                            |             
      Infiltration Cellular, Histiocyte    |       1                                                                  |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +     A  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                   2      |             
      Sinus, Fungus                        |          2                                                               |             
      Sinus, Inflammation, Acute           |          2                                                               |             
      Turbinate, Inflammation, Chronic     |       2                                                        1         |             
      Turbinate, Inflammation, Subacute    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens Capsule, Cataract               |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|             
                                           | 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |    2                                                                     |             
      Hematopoietic Cell Proliferation     |                                        2                                 |             
      Nephropathy                          | 4  3  3  2  3  2  1     3     2  1  1  3     4  3  1  2  3  2  2  2  3   |             
      Pelvis, Mineralization               |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|             
                                           | 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                             2            |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +  A  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Angiectasis                          |          1  2     2  2  2        1                                3      |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytologic Alterations                |                                  X        X                              |             
      Cytologic Alterations, Multiple      | X  X     X  X           X              X                                X|             
      Fibrosis, Focal                      |                         1                                                |             
      Hemorrhage                           |                                           1                              |             
      Hepatodiaphragmatic Nodule           | X                                               X                 X      |             
      Hyperplasia, Focal                   |                                  2  2              3  2           3      |             
      Hyperplasia, Nodular                 |       2              3                                                   |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  3  1  1     1  2  1  2  1  2     2  2     1  3  2           2  1  2|             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                            3        3                                    |             
      Periportal, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                      +  +   |             
      Inflammation, Acute                  |                            1                                             |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Inflammation, Acute             |                                                                   2      |             
      Fat, Necrosis                        |                                                                      2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Acinus, Atrophy, Focal               | 1     2  2        2                    1        2  1     1        3     2|             
      Artery, Inflammation, Chronic        | 3                                         2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|             
                                           | 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                               4                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                           2                              |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                             2            |             
      Ulcer                                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Inflammation, Acute                  |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                             +            |             
      Aorta, Inflammation, Chronic         |                                                                          |             
      Aorta, Mineralization                |                                                             3            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Cardiomyopathy                       | 2  1  1     1  2  1  2  1        2  3  1  2        2  2           2  1  2|             
      Atrium, Thrombosis                   |    4  3                    3                                      3     3|             
      Epicardium, Fibrosis, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                 2                       1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     M  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia                          | 1  1                 1     1        1     1                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia                          |             1                                                     3      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Pars Distalis, Angiectasis           |                      2                 2           2                     |             
      Pars Distalis, Cyst                  | 2                                                                        |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Cyst                                 |       1  1                                                               |             
      C-Cell, Hyperplasia                  |                                                    1              1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|             
                                           | 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 2                                                                        |             
      Inflammation, Acute                  | 2              2                          2                       2      |             
      Inflammation, Chronic                |       1                                                                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia, Focal                   |             1                          2                                 |             
      Inflammation, Acute                  | 1              2     2        1           3        2     2              1|             
      Inflammation, Chronic                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +     +  +  +|             
      Atrophy                              | 2     1  2  2     2  2           1  2  2  2        2              2     2|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Atrophy                              |                            2     2  3     1        3  2           2      |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Fibrosis                             |       2                                                                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Inguinal, Cyst                       |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mandibular, Cyst                     | 2        2              2                          2                     |             
      Mediastinal, Cyst                    |                   2                                                      |             
      Mediastinal, Hemorrhage              |                            1     1     1                                2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Cyst                                 |          2                                                               |             
      Edema                                |                            2                                             |             
      Hemorrhage                           |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Congestion                           |                         2              2                                 |             
      Fibrosis, Focal                      |                   1  2           2        2        3              1  3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                         2|             
      Infiltration Cellular, Histiocyte    |                                        3                                 |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  M  +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|             
                                           | 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +     +  +  +|             
      Edema                                |    2                                                                     |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hyperostosis                         |                                     2                                    |             
      Osteomalacia                         |                                           2                              |             
      Tarsal, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                                                          2               |             
      Thrombosis                           |                3                                                         |             
      Thrombosis, Multiple                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +     +  +  +        +  +  +  +        +              +     +|             
      Inflammation, Subacute               |       2                                                                  |             
      Ulcer                                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Congestion                           |                                                          2               |             
      Hemorrhage                           |                                        1                                 |             
      Hyperplasia, Adenomatous             |             1                                                            |             
      Infiltration Cellular, Histiocyte    |                         1        3        1                              |             
      Interstitium, Inflammation, Chronic  | 1                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                               1                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Sinus, Fungus                        |                                                       2  2               |             
      Sinus, Inflammation, Acute           | 2                 1                       2           2  3               |             
      Turbinate, Inflammation, Chronic     |       1                             2                                    |             
      Turbinate, Inflammation, Subacute    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Lens Capsule, Cataract               |                   3                                                      |             
      Retina, Atrophy                      |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|             
                                           | 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                           2                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Nephropathy                          | 4  1  2  3  1  2  3  4  3  2  1  3  2  3  4     2  3  2           3  2  3|             
      Pelvis, Mineralization               |    1                                                                     |             
      Renal Tubule, Degeneration           |                                                             4            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6| 7| 7| 4| 6|                                            |            |
                             DAY ON TEST   | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0|                                            |            |
                                           | 4| 0| 6| 6| 6| 1| 2| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +           +  +  +     +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +           +  +  +     +                                             |  47        |
      Edema                                |                            3                                             |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +           +  +  +     +                                             |  47        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +           +  +  +     +                                             |  47        |
      Parasite Metazoan                    | X                                                                        |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +           +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +           +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +           +  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +           +  +  +     +                                             |  47        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +           +  +  +     +                                             |  50        |
      Angiectasis                          | 2              2  2                                                      |     11  1.8|
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Cytologic Alterations                |                                                                          |      5     |
      Cytologic Alterations, Multiple      |                      X                                                   |     11     |
      Fibrosis, Focal                      |                                                                          |      2  1.5|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Hyperplasia, Focal                   | 2  2              2                                                      |     10  2.2|
      Hyperplasia, Nodular                 |                                                                          |      3  2.3|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  4.0|
      Bile Duct, Hyperplasia               |    2              1  2     2                                             |     38  1.7|
      Centrilobular, Degeneration          |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      2  3.0|
      Periportal, Vacuolization Cytoplasmic| 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Inflammation, Acute             |                                                                          |      2  1.5|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +           +  +  +     +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6| 7| 7| 4| 6|                                            |            |
                             DAY ON TEST   | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0|                                            |            |
                                           | 4| 0| 6| 6| 6| 1| 2| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Atrophy, Focal               |    2                                                                     |     14  1.6|
      Artery, Inflammation, Chronic        |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +           +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +           +  +  +     +                                             |  49        |
      Edema                                |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A           +  +  +     +                                             |  48        |
      Erosion                              |                                                                          |      4  1.3|
      Mineralization                       |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Aorta, Inflammation, Chronic         |                                                                          |      1  2.0|
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +  +  +     +                                             |  50        |
      Cardiomyopathy                       | 2              1  1        1                                             |     38  1.5|
      Atrium, Thrombosis                   |                                                                          |      6  3.0|
      Epicardium, Fibrosis, Focal          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +           +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +           +  +  +     +                                             |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +           +  +  +     +                                             |  48        |
      Hyperplasia                          | 1  1              1  1     1                                             |     17  1.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +  +  +     +                                             |  49        |
      Hyperplasia                          |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +           +  +  +     +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6| 7| 7| 4| 6|                                            |            |
                             DAY ON TEST   | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0|                                            |            |
                                           | 4| 0| 6| 6| 6| 1| 2| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                      2                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +           +  +  +     +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                      2                                                   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +  +  +     +                                             |  49        |
      Cyst                                 |                                                                          |      2  1.0|
      C-Cell, Hyperplasia                  |                                                                          |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +           +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +           +  +  +     +                                             |  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                            2                                             |     11  1.9|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +           +  +  +     +                                             |  50        |
      Hyperplasia, Focal                   |                                                                          |      6  1.3|
      Inflammation, Acute                  |                   1  1     1                                             |     17  1.5|
      Inflammation, Chronic                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +           +  +  +     +                                             |  48        |
      Atrophy                              | 2                 2  2                                                   |     25  1.8|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +           +  +  +     +                                             |  50        |
      Atrophy                              |                   2  2                                                   |     15  2.1|
      Interstitial Cell, Hyperplasia       |                            2                                             |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +  +  +     +                                             |  49        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +           +  +  +     +                                             |  50        |
      Inguinal, Cyst                       |                                                                          |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  2.0|
      Mandibular, Cyst                     |                                                                          |      7  1.9|
      Mediastinal, Cyst                    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6| 7| 7| 4| 6|                                            |            |
                             DAY ON TEST   | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0|                                            |            |
                                           | 4| 0| 6| 6| 6| 1| 2| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hemorrhage              |                2  2                                                      |      9  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +           +  +  +     +                                             |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |                2                                                         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +           +  +  +     +                                             |  49        |
      Congestion                           |                                                                          |      3  2.0|
      Fibrosis, Focal                      | 2                                                                        |      8  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +           +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +           +  +  +     +                                             |  48        |
      Dilatation                           |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +           +  +  +     +                                             |  49        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +  +  +     +                                             |  50        |
      Hyperostosis                         |                                                                          |      1  2.0|
      Osteomalacia                         |                                                                          |      1  2.0|
      Tarsal, Inflammation, Chronic Active |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +  +  +     +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      2  3.0|
      Thrombosis, Multiple                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +                 +  +                                                   |  26        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +           +  +  +     +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6| 7| 7| 4| 6|                                            |            |
                             DAY ON TEST   | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0|                                            |            |
                                           | 4| 0| 6| 6| 6| 1| 2| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  1.5|
      Hyperplasia, Adenomatous             |                            2                                             |      4  1.8|
      Infiltration Cellular, Histiocyte    |                                                                          |      4  1.5|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +           +  +  +     +                                             |  49        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Sinus, Fungus                        | 2                                                                        |      4  2.0|
      Sinus, Inflammation, Acute           | 2                          1                                             |      8  1.9|
      Turbinate, Inflammation, Chronic     |                      1                                                   |      5  1.4|
      Turbinate, Inflammation, Subacute    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   2        |
      Lens Capsule, Cataract               |                      3                                                   |      2  3.0|
      Retina, Atrophy                      |                      2                                                   |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +  +  +     +                                             |  50        |
      Cyst                                 | 2                                                                        |      3  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Nephropathy                          | 3  2           3  3  4     2                                             |     48  2.5|
      Pelvis, Mineralization               |                                                                          |      1  1.0|
      Renal Tubule, Degeneration           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +  +  +     +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|             
                                           | 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +              +     +        +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +              +              +              +        +   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +              +              +              +        +   |             
      Mineralization                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +              +              +              +        +   |             
      Inflammation, Acute                  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +              A              +              +        +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
      Angiectasis                          | 2           2     2  2                                2  2     2         |             
      Congestion                           |    1                          2                                          |             
      Cytologic Alterations                |                                                          X     X         |             
      Cytologic Alterations, Multiple      | X  X  X     X           X                                                |             
      Fibrosis                             |                                                             3            |             
      Hematopoietic Cell Proliferation     |                         1                                                |             
      Hepatodiaphragmatic Nodule           |       X                          X                                       |             
      Hyperplasia, Focal                   | 2                 2                                   2                  |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Chronic                |                                                                2         |             
      Thrombosis                           |                                                             3            |             
      Bile Duct, Hyperplasia, Cystic       |                                                                          |             
      Bile Duct, Hyperplasia               | 1  2  2  2  2  2  2  4  1        2  3        1        3  1     2  2      |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |          3                                      2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +              +  +  +        +              +        +   |             
      Accessory Spleen                     |                                  X                                       |             
      Acinus, Atrophy, Focal               |                                                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +     +              +     +        +  +           +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +     +              +     +        +  +           +        +   |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                               3                                          |             
      Ulcer                                |                                                 3                        |             
      Epithelium, Hyperplasia              |                2              2                                      2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +     +              +     +        +  +           +        +   |             
      Amyloid Deposition                   |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|             
                                           | 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |          2                                                               |             
      Mineralization                       |                               3                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                                          |             
      Aorta, Mineralization                |                               3                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +     +     +  +     +              +              +        +   |             
      Cardiomyopathy                       | 2        2     2     2  2     2                             1            |             
      Mineralization                       |                               3                                          |             
      Atrium, Thrombosis                   |          2           2        3                                          |             
      Endocardium, Thrombosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |                                     3                                    |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
      Hyperplasia                          | 2     2           2     2        1                    2        2     1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +              +  +  +        +              +        +   |             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  +              +              M              +        +   |             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +        +  +  +  +  +   |             
      Pars Distalis, Angiectasis           |                3                                               2         |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    2                                   2                                 |             
      Pars Nervosa, Ectopic Tissue         |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +  +              +              +           +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +              +              +              +        +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +  +     +        +     +              +  +  +  +   |             
      Inflammation, Acute                  |                                                                2     2   |             
                                            __________________________________________________________________________|             
   Prostate                                |                +              +              +              +        +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +           +  +     +     +  +  +  +     +  +        +  +     +  +   |             
      Atrophy                              | 2                 2     2        2  2                    2               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|             
                                           | 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                   4                 3                 3        4         |             
      Interstitial Cell, Hyperplasia       |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +              +              +              +        +   |             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +  +  +     +  +     +     +        +  +  +        +   |             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Iliac, Cyst                          |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                         3                                                |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mediastinal, Hemorrhage              | 2  1                             3                       2               |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +              +              +              +        +   |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
      Congestion                           |             2                                                            |             
      Fibrosis, Focal                      | 2     2                                                  2               |             
      Hematopoietic Cell Proliferation     |                         2     2                                      3   |             
      Infarct                              |                                                                          |             
      Necrosis                             |                                                                   3      |             
      Pigmentation                         |                                                                          |             
      Capsule, Fibrosis, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +              +              +              +        +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +     +     +              +              +        +   |             
      Dilatation                           |                         1                                                |             
                                            __________________________________________________________________________|             
   Skin                                    |       +        +  +  +        +              +              +        +   |             
      Cyst                                 |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +              +              +              +        +   |             
      Osteomalacia                         |                               3                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                             +              +        +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +     +  +           +           +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|             
                                           | 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                         1                                                |             
      Hyperplasia, Adenomatous             |                   2           3                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Nose                                    |                +              +              +              +        +   |             
      Sinus, Foreign Body                  |                                                                      2   |             
      Sinus, Fungus                        |                                                                          |             
      Sinus, Inflammation, Acute           |                                                                      2   |             
      Turbinate, Thrombosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +              +              +              +        +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +     +  +  +        +  +     +  +  +  +  +  +   |             
      Cyst                                 |                         1                                2               |             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy                          | 3  2  3  2  3  2  3     3     4  2  3        1  3     3  3     3  2  2   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +              +              +              +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|             
                             DAY ON TEST   | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|             
                                           | 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12500PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +           +  +     +  +        +              +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +           +  +     +  +        +              +  +                 +|             
      Hemorrhage                           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +           +  +     +  +        +              +                    +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    A           A  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A           A  +     +  +        +              +                    +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A           A  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A           A  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +     +  +           +  +  +  +     +  +  +|             
      Angiectasis                          |                            1  1        2                 2  2     2      |             
      Congestion                           |                2                                      3                  |             
      Cytologic Alterations                | X        X  X           X              X                 X  X            |             
      Cytologic Alterations, Multiple      |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Hyperplasia, Focal                   |    2        2                                         2                 2|             
      Hyperplasia, Multifocal              |                               2                                          |             
      Inflammation, Chronic                |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia, Cystic       |                                                             3            |             
      Bile Duct, Hyperplasia               | 1  2  2  1  2  2  2           2     2  2           1     2  2     2  2   |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                     2                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +           +  +     +  +        +              +                    +|             
      Accessory Spleen                     |                                                                          |             
      Acinus, Atrophy, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +           +  +     +  +        +              +                    +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +        +  +     +  +        +              +  +                 +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +        +  +     +  +        +              +  +                 +|             
      Edema                                |                                                       3                  |             
      Erosion                              |                                     1                                    |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |       2                    2                                            2|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        +  +     +  +        +              +  +                 +|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|             
                             DAY ON TEST   | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|             
                                           | 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12500PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                     1              1                    2|             
      Mineralization                       |                                                                          |             
      Ulcer                                |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +  +     +  +        +              +                    +|             
      Cardiomyopathy                       |    2           2  1     1                          2                    2|             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                         3                                                |             
      Endocardium, Thrombosis              |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
      Hyperplasia                          |             2                                                            |             
      Inflammation, Subacute               |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
      Hyperplasia                          |          2  2           3     1     1  1              2  1  2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +           +  +     +  +        +              +                    +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +           +  +     M  +        +     +        +                    +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
      Pars Distalis, Angiectasis           |                         2                                                |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 1     2  1              2                                               2|             
      Pars Nervosa, Ectopic Tissue         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +  +     +  +        +              +     +              +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +  +        +        +              +                    +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +  +     +  +        +              +                    +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +  +     +  +        +              +                    +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     A  +     +  +  +     +  +  +        +  +     +     +     +|             
      Atrophy                              | 2        1                    3        2  2                 2            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|             
                             DAY ON TEST   | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|             
                                           | 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12500PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |          2              2                             3  1           2   |             
      Interstitial Cell, Hyperplasia       |                         2  1        1                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +  +     +  +        +              +                    +|             
      Hyperplasia                          |                   2     2  2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +     +  +     +  +  +     +     +        +  +     +           +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Iliac, Cyst                          |                         2                                                |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                    2                     |             
      Mediastinal, Hemorrhage              |          1                    1           1                              |             
      Renal, Hemorrhage                    |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +  +     +  +        +     +        +  +                 +|             
      Cyst                                 |                                           2                              |             
      Hemorrhage                           | 2  2                                                  4                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +     +  +           +  +  +  +     +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                               1                          2               |             
      Hematopoietic Cell Proliferation     |                         2                          2                     |             
      Infarct                              |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                        1                                 |             
      Capsule, Fibrosis, Focal             | 1                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +           +  M     +  +        +              +                    M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +     +  +     +  +        +              +                    +|             
      Dilatation                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +  +     +  +  +     +     +        +                    +|             
      Cyst                                 |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +           +  +     +  +        +              +                    +|             
      Osteomalacia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +  +     +  +        +              +                    +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +  +  +     +  +  +     +              +     +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|             
                             DAY ON TEST   | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|             
                                           | 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12500PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                2                                                         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +           +  +     +  +        +              +                    +|             
      Sinus, Foreign Body                  |                                                                          |             
      Sinus, Fungus                        |                         2                                                |             
      Sinus, Inflammation, Acute           |                         2                                               1|             
      Turbinate, Thrombosis                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +           +  +     +  +        +              +                    +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +     +  +  +     +  +  +        +  +  +  +     +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy                          | 3  1  2     3     1     2  1  4     1  3  2        2  4  4  4     2  2   |             
      Pigmentation                         |                                                                         1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +           +  +     +  +        +              +                    +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 5| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3|                                            |            |
                                           | 4| 3| 5| 4| 3| 6| 8| 3| 5| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +                                                            |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +                                                            |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +                                                            |  15        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +                                                            |  14        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +                                                            |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +                                                            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +                                                            |  12        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +                                                            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +                                                            |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +                                             |  49        |
      Angiectasis                          | 2     2              2                                                   |     16  1.9|
      Congestion                           |                                                                          |      4  2.0|
      Cytologic Alterations                | X        X              X  X                                             |     13     |
      Cytologic Alterations, Multiple      |                                                                          |      5     |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |          X                                                               |      4     |
      Hyperplasia, Focal                   |    2                                                                     |      8  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia, Cystic       |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 2  2  3  2  2     1     2  2                                             |     39  1.9|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                    +                                             |   2        |
      Fat, Necrosis                        |       3                    2                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +                                                            |  16        |
      Accessory Spleen                     |                                                                          |      1     |
      Acinus, Atrophy, Focal               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +                                                            |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +        +                                                   |  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +        +                                                   |  21        |
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Acute                  |                      2                                                   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 5| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3|                                            |            |
                                           | 4| 3| 5| 4| 3| 6| 8| 3| 5| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      4  2.3|
      Epithelium, Hyperplasia              |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +        +                                                   |  21        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Erosion                              |                      2                                                   |      5  1.6|
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +                                                            |  20        |
      Cardiomyopathy                       | 2     2     1                                                            |     16  1.8|
      Mineralization                       |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |       3                                                                  |      5  2.6|
      Endocardium, Thrombosis              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |    1                                                                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +                                             |  50        |
      Hyperplasia                          | 1  2  4  2                                                               |     21  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +                                                            |  16        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +                                                            |  15        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +                                             |  49        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.3|
      Pars Distalis, Cyst                  |          2              2                                                |      2  2.0|
      Pars Distalis, Hyperplasia           |       2                 2                                                |      9  1.8|
      Pars Nervosa, Ectopic Tissue         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +                                                            |  18        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 5| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3|                                            |            |
                                           | 4| 3| 5| 4| 3| 6| 8| 3| 5| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +                                                            |  13        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +           +                                                            |  20        |
      Inflammation, Acute                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |             +                                                            |  14        |
      Inflammation, Acute                  |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +  +     A  +     +                                             |  37        |
      Atrophy                              | 2        2                 2                                             |     15  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +  +  +                                             |  50        |
      Atrophy                              | 2     2  2  3           2                                                |     14  2.5|
      Interstitial Cell, Hyperplasia       |                      1                                                   |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +                                                            |  14        |
      Hyperplasia                          |             2                                                            |      5  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +           +  +                                             |  33        |
      Axillary, Hyperplasia, Lymphoid      |       2                                                                  |      1  2.0|
      Iliac, Cyst                          |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |          2                                                               |      8  1.6|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +                                                            |  18        |
      Cyst                                 |       X                                                                  |      2  2.0|
      Hemorrhage                           |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +                                             |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                                                          |      5  1.8|
      Hematopoietic Cell Proliferation     |                                                                          |      5  2.2|
      Infarct                              |                            2                                             |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Capsule, Fibrosis, Focal             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +           +                                                |  14        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +     +                                                            |  18        |
      Dilatation                           |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 5| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3|                                            |            |
                                           | 4| 3| 5| 4| 3| 6| 8| 3| 5| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    12500PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +     +     +                                                |  21        |
      Cyst                                 |                         X                                                |      1     |
      Edema                                |                   2                                                      |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +                                                            |  14        |
      Osteomalacia                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +                                                            |  13        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +  +           +  +                                             |  30        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Adenomatous             |          2              2                                                |      4  2.3|
      Infiltration Cellular, Histiocyte    |    2                                                                     |      1  2.0|
      Interstitium, Inflammation, Chronic  |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +                                                            |  14        |
      Sinus, Foreign Body                  |                                                                          |      1  2.0|
      Sinus, Fungus                        |             2                                                            |      2  2.0|
      Sinus, Inflammation, Acute           |             3                                                            |      4  2.0|
      Turbinate, Thrombosis                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +                                                            |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +        +     +                                             |  45        |
      Cyst                                 |                                                                          |      2  1.5|
      Fibrosis, Focal                      |                            2                                             |      1  2.0|
      Nephropathy                          | 3  2  3  3  2        2     2                                             |     42  2.5|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +                                                            |  14        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|             
                                           | 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +     +     +        +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +     +     +        +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     1              2  2  2                                1  2        2|             
      Congestion                           |                                                    2                     |             
      Cytologic Alterations                |                                                                          |             
      Cytologic Alterations, Multiple      | X     X                 X                                                |             
      Hepatodiaphragmatic Nodule           |                                        X                 X               |             
      Hyperplasia, Focal                   |                                                                      2  2|             
      Hyperplasia, Multifocal              |                                                                          |             
      Necrosis, Focal                      |                   2                                                      |             
      Bile Duct, Hyperplasia               | 2     2     2  2  2  2  2  2     1     2           1     2  1  2  2  3  2|             
      Centrilobular, Necrosis              |          3                                                               |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |    3                                                  2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                         +            |             
      Fat, Necrosis                        |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |                                                                      2   |             
      Acinus, Atrophy, Focal               |    1  1        2        1  1                             2     1         |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   1                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  M|             
      Edema                                |             3                                                            |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Erosion                              |             2                                   1     2                  |             
      Inflammation, Acute                  |                                                    2                     |             
      Pigmentation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +  +         |             
      Inflammation, Chronic                |                                                                3         |             
      Epithelium, Hyperplasia              |                                                             1  2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|             
                                           | 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2     1  2  2  2  2  1     1              2     1  2  2  2  2     2|             
      Atrium, Thrombosis                   |                                                             2        3   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                  2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2     1  1  2                       2     2  1     1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +     +     M        +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                 1                        |             
      Pars Distalis, Cyst                  |                   2                                         2           2|             
      Pars Distalis, Hyperplasia           |                2  2              1                    1                  |             
      Pars Nervosa, Ectopic Tissue         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
      Inflammation, Acute                  |                                        1                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2                                                                  |             
      Inflammation, Acute                  |       1           2  2                 1                 2               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +     +     +        A  +  +  +  +  +  A  +  +|             
      Atrophy                              |       2        2  2     2  2                             2  2  2        2|             
      Inflammation, Acute                  |    3                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2     2  2  2        2                          2     2  2     2  2|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|             
                                           | 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Inguinal, Cyst                       |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                2         |             
      Mandibular, Cyst                     |                                                                         2|             
      Mandibular, Hemorrhage               |                                                          2               |             
      Mandibular, Hyperplasia, Lymphoid    |                      1     2                                             |             
      Mediastinal, Hemorrhage              |                   2  2  2  2                                1  2         |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Renal, Inflammation, Chronic         |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                                               |             
      Edema                                |                                  2                                       |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Congestion                           | 2                                                  2                     |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis, Focal                      |                      2                                                   |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Infiltration Cellular, Histiocyte    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  M  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                         1                                                |             
      Hyperplasia                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                         2                                                |             
      Epithelium, Lip, Hyperplasia         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                        2        2                 3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +        +  +  +  +  +                             +  +  +        +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|             
                                           | 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Adenomatous             |       2                                                                  |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                         1                                                |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                    2                     |             
      Sinus, Foreign Body                  |                                                                          |             
      Sinus, Fungus                        |          3                                                               |             
      Sinus, Inflammation, Acute           |          3                                                        1  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                         +         |             
      Sclera, Metaplasia, Osseous          |                                                                2         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            1                                             |             
      Developmental Malformation           |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy                          | 3  1  3     2  3  3  3  3  3     1     1           2  2  3  3  2     3  2|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Mineralization               |                                                    1  2                  |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +     +        +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|             
                             DAY ON TEST   | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|             
                                           | 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Angiectasis                          |          1              1     2     2                    2  2     3      |             
      Congestion                           |                                                       2                  |             
      Cytologic Alterations                |                                                          X               |             
      Cytologic Alterations, Multiple      |       X  X        X     X              X                                 |             
      Hepatodiaphragmatic Nodule           |          X  X     X     X                                                |             
      Hyperplasia, Focal                   | 2                                   2                             2     2|             
      Hyperplasia, Multifocal              |                                                                          |             
      Necrosis, Focal                      |                                                                         1|             
      Bile Duct, Hyperplasia               | 2  2  1     3     2     2  2  1     3  1        2     2  2  2  2  2     3|             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |    3                       3  2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Acinus, Atrophy, Diffuse             |                                     3                                    |             
      Acinus, Atrophy, Focal               |    1        1              1           2                    2            |             
      Acinus, Hyperplasia, Focal           |                         2                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                         3|             
      Epithelium, Hyperplasia              |                                              2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                                2         |             
      Ulcer                                | 2                          1  2                                         3|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|             
                             DAY ON TEST   | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|             
                                           | 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Cardiomyopathy                       |    2  1  2        2     2     2     2  1        1     2  1  2     1     1|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Necrosis, Focal                      |                            2                                             |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Hyperplasia                          |       1                                         1        2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +     +     +  +  +     +  +     +  +     +  M  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |          2                                                               |             
      Pars Distalis, Hyperplasia           |    3  1                                2                    2            |             
      Pars Nervosa, Ectopic Tissue         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      C-Cell, Hyperplasia                  |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +     +  +  +     +  +     M  +     +  +  +  +  +     +|             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Acute                  | 2           1                          1                 1  1  1         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Hyperplasia, Focal                   |                                                                   2      |             
      Inflammation, Acute                  |                            3  2                          1               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  M  +     +|             
      Atrophy                              |    2  2  2        2     2           2  2                    2     2      |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Atrophy                              | 2     2     2              2        3        1           2  3     3      |             
      Interstitial Cell, Hyperplasia       |                                              1                 1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|             
                             DAY ON TEST   | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|             
                                           | 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Inguinal, Cyst                       |                                                                   2      |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                   2      |             
      Mandibular, Cyst                     |       2                 2                                                |             
      Mandibular, Hemorrhage               |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mediastinal, Hemorrhage              |       2  1                             1                                 |             
      Mediastinal, Pigmentation            |                                                                   2      |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Renal, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |          3                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Amyloid Deposition                   |                                                                          |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                               2                                          |             
      Fibrosis, Focal                      |                   3     2                                   2            |             
      Hematopoietic Cell Proliferation     |                               2              2           2               |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Dilatation                           |                                                       1                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Hyperkeratosis                       |                                                                          |             
      Epithelium, Lip, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Hemorrhage                           |                                                                1         |             
      Thrombosis                           |                                                 3                       3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +        +     +           +  +                    +     +      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|             
                             DAY ON TEST   | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|             
                                           | 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    25000PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |    2                                                                     |             
      Foreign Body                         |                                                             2            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
      Hyperplasia, Adenomatous             |       2                                                                  |             
      Infiltration Cellular, Histiocyte    |                                                             2            |             
      Pigmentation                         |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                        1                    2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |       2                                                                  |             
      Sinus, Foreign Body                  |                                                             2           2|             
      Sinus, Fungus                        |       3                                      3                           |             
      Sinus, Inflammation, Acute           |       2                                      3        2     3  2        2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
      Cyst                                 |                                                       2                  |             
      Developmental Malformation           |                               X                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy                          | 1  3  3  2  1     3     2  1  2     3  3     1  1     3  2  3     2     1|             
      Pelvis, Dilatation                   |                                        2                                 |             
      Pelvis, Mineralization               |                                                          1               |             
      Renal Tubule, Degeneration           |                                              4                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +     +  +  +     +  +     +  +     +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |    1           2                                                         |     17  1.7|
      Congestion                           |                                                                          |      2  2.0|
      Cytologic Alterations                |                                                                          |      1     |
      Cytologic Alterations, Multiple      | X  X              X     X                                                |     12     |
      Hepatodiaphragmatic Nodule           |                            X                                             |      7     |
      Hyperplasia, Focal                   |                2           3                                             |      8  2.1|
      Hyperplasia, Multifocal              |          1                                                               |      1  1.0|
      Necrosis, Focal                      |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               | 2  2  2  1  2  3  1  2  2  3                                             |     44  2.0|
      Centrilobular, Necrosis              |                            4                                             |      2  3.5|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |             3                                                            |      6  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +                                                                     |   5        |
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | M  +  +  +  +  +  +  +  +  +                                             |  49        |
      Acinus, Atrophy, Diffuse             |                                                                          |      2  2.5|
      Acinus, Atrophy, Focal               |       1  2  2  2           2                                             |     17  1.5|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Edema                                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Erosion                              |                                                                          |      3  1.7|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                               |   3        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       | 2  2  1  2  2  1  1  2     1                                             |     40  1.6|
      Atrium, Thrombosis                   |       2                    4                                             |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |          1              1                                                |     13  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                            1                                             |      3  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +                                             |  45        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                         1                                                |      2  1.0|
      Pars Distalis, Cyst                  |    X     2                 3                                             |      7  2.2|
      Pars Distalis, Hyperplasia           |                                                                          |      8  1.8|
      Pars Nervosa, Ectopic Tissue         |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Hyperplasia                  |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Acute                  |             1                                                            |      8  1.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  M                                             |  49        |
      Hyperplasia, Focal                   |          2  2           2                                                |      5  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      8  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Atrophy                              |    2     2  2  2  2     2  2                                             |     25  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              |    2  2     3        3     1                                             |     24  2.1|
      Interstitial Cell, Hyperplasia       |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inguinal, Cyst                       |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  2.0|
      Mandibular, Cyst                     |                                                                          |      3  2.0|
      Mandibular, Hemorrhage               |                                                                          |      1  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      2  1.5|
      Mediastinal, Hemorrhage              |                            1                                             |     10  1.6|
      Mediastinal, Pigmentation            |    2           1                                                         |      3  1.7|
      Pancreatic, Hemorrhage               |                2                                                         |      1  2.0|
      Renal, Inflammation, Chronic         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Amyloid Deposition                   |                            4                                             |      1  4.0|
      Congestion                           |                                                                          |      2  2.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Fibrosis, Focal                      |       2     2           2                                                |      7  2.1|
      Hematopoietic Cell Proliferation     | 2                                                                        |      5  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  M  +                                             |  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Dilatation                           |                                                                          |      2  1.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Epithelium, Lip, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Thrombosis                           |             3                                                            |      6  2.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +     +  +  +  +     +  +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage                           |       2                                                                  |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Adenomatous             |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic  | 1  1     1                                                               |      5  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  2.0|
      Sinus, Foreign Body                  |                                                                          |      2  2.0|
      Sinus, Fungus                        |                                                                          |      3  3.0|
      Sinus, Inflammation, Acute           |                                                                          |      9  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Sclera, Metaplasia, Osseous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                         3                                                |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05706-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                              4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID                          Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 12:49:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 4| 6| 9| 8| 3| 4| 8| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    25000PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis, Focal                      |                         3                                                |      1  3.0|
      Nephropathy                          | 2  2  2  1  2  3  2  1  2  3                                             |     46  2.2|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Pelvis, Mineralization               |                                                                          |      3  1.3|
      Renal Tubule, Degeneration           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------