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https://ntp.niehs.nih.gov/go/21250

TDMS Study 96003-05 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BIORELIANCE                                          ALLYL BROMIDE                                             DATE: 10/02/02  
EXPERIMENT: 96003 TEST: 05                                                                                        TIME: 07:49:56    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: GAVAGE                                                 NTP:  C96003      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BIORELIANCE                                      ALLYL BROMIDE                                               DATE: 10/02/02    
EXPERIMENT: 96003 TEST: 05                                                                                        TIME:  8:04:57    
SPECIES: MICE, P53+/-(C57BL/6)                                                                                                      
TEST TYPE: 26                                       ROUTE: ORAL GAVAGE                                            NTP:  C96003      
CONT: NO1-ES-25408                                                                                                CAS: 106-95-6     
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                               
                                         26 ORAL GAVAGE STUDY OF ALLYL BROMIDE                                                      
==========================================================================================================================          
WEEK     VEHICLE CONTROL        0.5     MG/KG            1 MG/KG                  2 MG/KG                  4 MG/KG                  
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        24.6       15        25.2    102.4    15      24.3     98.8    15      24.6    100.0    15      24.9    101.2    15      
  1        24.6       15        25.2    102.4    15      24.3     98.8    15      24.6    100.0    15      24.9    101.2    15      
  2        25.0       15        25.0    100.0    15      24.3     97.2    15      24.9     99.6    15      25.1    100.4    15      
  3        25.6       15        25.7    100.4    15      25.6    100.0    15      25.8    100.8    15      26.1    102.0    15      
  4        26.4       15        27.2    103.0    15      25.7     97.3    15      26.3     99.6    15      27.1    102.7    15      
  5        27.2       15        28.6    105.1    15      26.9     98.9    15      27.6    101.5    15      28.4    104.4    15      
  6        27.8       15        29.0    104.3    15      27.7     99.6    15      28.0    100.7    15      28.8    103.6    15      
  7        29.0       15        29.8    102.8    15      28.6     98.6    15      29.3    101.0    15      29.2    100.7    15      
  8        29.8       15        31.3    105.0    15      29.6     99.3    15      30.4    102.0    15      30.7    103.0    15      
  9        30.6       15        32.3    105.6    15      30.8    100.7    15      30.6    100.0    15      32.2    105.2    15      
 10        31.5       15        33.6    106.7    15      31.6    100.3    15      31.9    101.3    15      33.6    106.7    15      
 11        32.3       15        34.6    107.1    15      32.4    100.3    15      33.2    102.8    15      34.6    107.1    15      
 12        33.0       15        35.3    107.0    15      33.6    101.8    15      34.2    103.6    15      35.5    107.6    15      
 13        34.0       15        36.0    105.9    15      34.7    102.1    15      35.2    103.5    15      36.5    107.4    15      
 14        34.7       15        36.9    106.3    15      35.7    102.9    15      35.9    103.5    15      37.3    107.5    15      
 15        35.8       15        38.1    106.4    15      36.5    102.0    15      36.9    103.1    15      38.2    106.7    15      
 16        36.7       15        39.0    106.3    15      37.9    103.3    15      37.5    102.2    15      39.3    107.1    15      
 17        37.3       15        39.9    107.0    15      38.7    103.8    15      38.3    102.7    15      39.8    106.7    15      
 18        37.9       15        41.1    108.4    15      39.4    104.0    15      39.4    104.0    15      39.9    105.3    15      
 19        38.5       15        41.6    108.1    15      39.8    103.4    15      39.8    103.4    15      39.7    103.1    15      
 20        39.2       15        42.2    107.7    15      40.2    102.6    15      40.2    102.6    15      40.1    102.3    15      
 21        39.7       15        42.8    107.8    15      41.1    103.5    15      40.7    102.5    15      41.7    105.0    15      
 22        40.6       15        43.4    106.9    15      41.8    103.0    15      41.3    101.7    15      42.2    103.9    15      
 23        41.1       15        44.2    107.5    15      42.8    104.1    15      42.1    102.4    15      43.2    105.1    15      
 24        41.5       15        44.7    107.7    15      43.3    104.3    15      42.6    102.7    15      43.9    105.8    15      
 25        41.7       15        45.2    108.4    15      43.6    104.6    15      42.9    102.9    15      44.0    105.5    15      
 26        42.4       15        45.4    107.1    15      44.3    104.5    15      43.3    102.1    15      44.7    105.4    15      
 27        42.9       15        45.5    106.1    15      44.6    104.0    15      43.6    101.6    15      44.9    104.7    15      
 28        43.4       15        45.7    105.3    15      44.9    103.5    15      44.2    101.8    15      45.5    104.8    15      
 29        43.9       15        46.6    106.2    15      44.7    101.8    15      45.0    102.5    15      45.9    104.6    15      
 30        43.5       15        46.6    107.1    15      44.8    103.0    15      45.3    104.1    15      46.4    106.7    15      
 31        44.1       15        46.7    105.9    15      45.4    102.9    15      45.5    103.2    15      46.7    105.9    15      
 32        44.0       15        47.0    106.8    15      46.1    104.8    15      46.0    104.5    15      46.0    104.5    15      
 33        44.7       15        48.0    107.4    15      46.9    104.9    15      46.3    103.6    15      47.8    106.9    14      
 34        44.7       15        48.4    108.3    15      46.8    104.7    15      45.9    102.7    15      46.6    104.3    14      
 35        45.2       15        49.2    108.8    14      47.8    105.8    15      46.8    103.5    15      46.8    103.5    14      
 36        45.6       15        49.2    107.9    14      47.2    103.5    15      46.4    101.8    15      47.1    103.3    14      
 37        45.8       15        49.9    109.0    14      47.9    104.6    15      45.0     98.3    15      47.9    104.6    14      
 38        46.7       15        50.1    107.3    14      48.6    104.1    15      46.2     98.9    15      48.6    104.1    14      
 39        46.8       15        50.0    106.8    14      49.2    105.1    15      47.8    102.1    15      49.3    105.3    14      
 40        47.5       15        49.4    104.0    14      49.9    105.1    15      48.7    102.5    15      49.8    104.8    13      
TERM. SAC.            15                         14                       15                       15                       13      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                                                                  
26 ORAL GAVAGE STUDY OF ALLYL BROMIDE                                                                                               
===============================                                                                                                     
     8 MG/KG                                                                                                                        
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B    25.1    102.0    15                                                                                                          
  1    25.1    102.0    15                                                                                                          
  2    25.2    100.8    15                                                                                                          
  3    26.1    102.0    15                                                                                                          
  4    27.0    102.3    15                                                                                                          
  5    28.1    103.3    15                                                                                                          
  6    28.9    104.0    15                                                                                                          
  7    30.0    103.4    15                                                                                                          
  8    31.2    104.7    15                                                                                                          
  9    32.1    104.9    15                                                                                                          
 10    33.2    105.4    15                                                                                                          
 11    33.9    105.0    15                                                                                                          
 12    34.9    105.8    15                                                                                                          
 13    35.6    104.7    15                                                                                                          
 14    36.6    105.5    15                                                                                                          
 15    37.9    105.9    15                                                                                                          
 16    38.9    106.0    15                                                                                                          
 17    39.8    106.7    15                                                                                                          
 18    40.6    107.1    15                                                                                                          
 19    41.2    107.0    15                                                                                                          
 20    41.6    106.1    15                                                                                                          
 21    42.0    105.8    15                                                                                                          
 22    42.8    105.4    15                                                                                                          
 23    43.4    105.6    15                                                                                                          
 24    44.0    106.0    15                                                                                                          
 25    44.5    106.7    15                                                                                                          
 26    45.1    106.4    15                                                                                                          
 27    45.7    106.5    15                                                                                                          
 28    46.0    106.0    15                                                                                                          
 29    46.0    104.8    15                                                                                                          
 30    46.4    106.7    15                                                                                                          
 31    46.9    106.3    15                                                                                                          
 32    47.6    108.2    15                                                                                                          
 33    48.2    107.8    15                                                                                                          
 34    48.1    107.6    15                                                                                                          
 35    49.3    109.1    15                                                                                                          
 36    49.4    108.3    15                                                                                                          
 37    49.2    107.4    15                                                                                                          
 38    49.5    106.0    15                                                                                                          
 39    50.2    107.3    15                                                                                                          
 40    50.5    106.3    15                                                                                                          
TERM. SAC.              15                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                             
                                         26 ORAL GAVAGE STUDY OF ALLYL BROMIDE                                                      
==========================================================================================================================          
WEEK     VEHICLE CONTROL        0.5     MG/KG            1 MG/KG                  2 MG/KG                  4 MG/KG                  
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        20.0       15        20.1    100.5    15      19.6     98.0    15      20.1    100.5    15      20.1    100.5    15      
  1        20.0       15        20.1    100.5    15      19.6     98.0    15      20.1    100.5    15      20.1    100.5    15      
  2        20.2       15        20.2    100.0    15      19.6     97.0    15      20.2    100.0    15      20.3    100.5    15      
  3        21.0       15        21.0    100.0    15      20.6     98.1    15      20.8     99.0    15      21.0    100.0    15      
  4        22.1       15        21.9     99.1    15      21.1     95.5    15      21.4     96.8    15      21.6     97.7    15      
  5        22.4       15        22.5    100.4    15      22.1     98.7    15      22.1     98.7    15      22.3     99.6    15      
  6        22.6       15        22.7    100.4    15      22.3     98.7    15      22.3     98.7    15      22.8    100.9    15      
  7        23.2       15        22.9     98.7    15      22.9     98.7    15      22.7     97.8    15      23.0     99.1    15      
  8        23.6       15        23.7    100.4    15      23.4     99.2    15      22.8     96.6    15      23.3     98.7    15      
  9        24.0       15        23.9     99.6    15      23.9     99.6    15      23.9     99.6    15      24.0    100.0    15      
 10        24.6       15        24.6    100.0    15      24.5     99.6    15      24.3     98.8    15      23.9     97.2    15      
 11        24.6       15        25.6    104.1    15      25.0    101.6    15      24.8    100.8    15      24.7    100.4    15      
 12        25.3       15        25.8    102.0    15      25.8    102.0    15      25.3    100.0    15      25.1     99.2    15      
 13        25.7       15        26.5    103.1    15      26.5    103.1    15      25.8    100.4    15      25.6     99.6    15      
 14        26.2       15        26.7    101.9    15      26.5    101.1    15      26.6    101.5    15      26.1     99.6    15      
 15        27.3       15        28.0    102.6    15      27.5    100.7    15      27.4    100.4    15      27.0     98.9    15      
 16        27.8       15        28.2    101.4    15      28.8    103.6    15      28.1    101.1    15      27.3     98.2    15      
 17        28.7       15        29.1    101.4    15      29.4    102.4    15      28.7    100.0    15      27.5     95.8    15      
 18        29.0       15        30.0    103.4    15      30.0    103.4    15      29.3    101.0    15      27.9     96.2    15      
 19        29.7       15        31.0    104.4    15      29.8    100.3    15      29.5     99.3    15      28.2     94.9    15      
 20        30.7       15        31.8    103.6    15      30.3     98.7    15      30.2     98.4    15      29.1     94.8    15      
 21        31.3       15        32.5    103.8    15      31.3    100.0    15      31.0     99.0    15      29.8     95.2    15      
 22        32.6       15        33.2    101.8    15      32.0     98.2    15      31.6     96.9    15      30.0     92.0    15      
 23        33.4       15        33.8    101.2    15      33.1     99.1    15      32.8     98.2    15      30.7     91.9    15      
 24        33.8       15        34.5    102.1    15      33.8    100.0    15      33.1     97.9    15      31.1     92.0    15      
 25        34.1       15        34.8    102.1    15      34.3    100.6    15      33.3     97.7    15      31.1     91.2    15      
 26        34.4       15        35.7    103.8    15      34.8    101.2    15      34.1     99.1    15      31.7     92.2    15      
 27        35.3       15        36.2    102.5    15      35.3    100.0    15      34.5     97.7    15      32.3     91.5    15      
 28        36.2       15        37.3    103.0    15      35.9     99.2    15      35.0     96.7    15      32.9     90.9    15      
 29        36.7       15        38.3    104.4    15      36.2     98.6    15      35.8     97.5    15      33.9     92.4    15      
 30        36.8       15        38.1    103.5    15      36.1     98.1    15      36.4     98.9    15      34.0     92.4    15      
 31        36.4       15        38.6    106.0    15      36.2     99.5    15      36.7    100.8    15      33.9     93.1    15      
 32        36.4       15        39.5    108.5    15      36.6    100.5    15      37.1    101.9    15      34.6     95.1    15      
 33        37.6       14        40.1    106.6    15      38.2    101.6    14      37.0     98.4    15      35.1     93.4    15      
 34        37.9       14        39.8    105.0    15      38.1    100.5    14      37.4     98.7    15      35.4     93.4    15      
 35        38.3       14        40.1    104.7    15      39.9    104.2    13      37.8     98.7    15      36.2     94.5    15      
 36        39.6       14        40.5    102.3    15      41.0    103.5    13      38.3     96.7    15      36.3     91.7    15      
 37        40.2       14        42.5    105.7    14      41.7    103.7    13      39.0     97.0    14      36.6     91.0    15      
 38        42.5       13        43.3    101.9    14      42.6    100.2    13      40.2     94.6    14      37.1     87.3    15      
 39        42.7       13        43.4    101.6    14      42.7    100.0    13      41.5     97.2    14      37.7     88.3    15      
 40        43.0       13        43.4    100.9    14      43.8    101.9    13      40.3     93.7    14      37.7     87.7    15      
TERM. SAC.            13                         14                       13                       14                       15      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                                                                
26 ORAL GAVAGE STUDY OF ALLYL BROMIDE                                                                                               
===============================                                                                                                     
     8 MG/KG                                                                                                                        
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B    19.9     99.5    15                                                                                                          
  1    19.9     99.5    15                                                                                                          
  2    20.3    100.5    15                                                                                                          
  3    20.8     99.0    15                                                                                                          
  4    21.3     96.4    15                                                                                                          
  5    22.3     99.6    15                                                                                                          
  6    22.9    101.3    15                                                                                                          
  7    23.1     99.6    15                                                                                                          
  8    23.7    100.4    15                                                                                                          
  9    24.6    102.5    15                                                                                                          
 10    25.1    102.0    15                                                                                                          
 11    25.9    105.3    15                                                                                                          
 12    26.7    105.5    15                                                                                                          
 13    27.9    108.6    15                                                                                                          
 14    28.4    108.4    15                                                                                                          
 15    29.7    108.8    15                                                                                                          
 16    30.5    109.7    15                                                                                                          
 17    31.4    109.4    15                                                                                                          
 18    32.0    110.3    15                                                                                                          
 19    32.4    109.1    15                                                                                                          
 20    33.6    109.4    15                                                                                                          
 21    34.5    110.2    15                                                                                                          
 22    35.4    108.6    15                                                                                                          
 23    36.3    108.7    15                                                                                                          
 24    37.2    110.1    15                                                                                                          
 25    37.6    110.3    15                                                                                                          
 26    38.1    110.8    15                                                                                                          
 27    39.1    110.8    15                                                                                                          
 28    39.7    109.7    15                                                                                                          
 29    40.4    110.1    15                                                                                                          
 30    41.0    111.4    15                                                                                                          
 31    41.1    112.9    15                                                                                                          
 32    42.0    115.4    15                                                                                                          
 33    42.2    112.2    15                                                                                                          
 34    41.8    110.3    15                                                                                                          
 35    42.0    109.7    15                                                                                                          
 36    42.0    106.1    15                                                                                                          
 37    41.1    102.2    15                                                                                                          
 38    41.8     98.4    15                                                                                                          
 39    42.4     99.3    15                                                                                                          
 40    45.2    105.1    13                                                                                                          
TERM. SAC.              13                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.