TDMS Study 93021-05 Pathology Tables
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
150 DAY SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 538-75-0
Lock Date: 03/26/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| | |
DAY ON TEST | 4| 0| 4| 4| 5| 4| 4| 8| 4| 4| | |
| 1| 0| 1| 1| 8| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
Odontoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + M | 8 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| | |
DAY ON TEST | 4| 0| 4| 4| 5| 4| 4| 8| 4| 4| | |
| 1| 0| 1| 1| 8| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 9 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
Leukemia Erythrocytic | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| | |
DAY ON TEST | 8| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
| 4| 1| 1| 1| 1| 1| 1| 1| 1| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
.75 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 3 |
__________________________________________________________________________|____________|
Gallbladder | + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 4 |
Squamous Cell Papilloma | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 3 |
__________________________________________________________________________|____________|
Tooth | + + + + + | 5 |
Odontoma | X X X X X | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 3 |
__________________________________________________________________________|____________|
Heart | + + + | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 4 |
C-Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M M | 1 |
__________________________________________________________________________|____________|
Ovary | + + + | 3 |
__________________________________________________________________________|____________|
Uterus | + + + | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| | |
DAY ON TEST | 8| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
| 4| 1| 1| 1| 1| 1| 1| 1| 1| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
.75 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 3 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + | 3 |
__________________________________________________________________________|____________|
Nose | + + + | 3 |
__________________________________________________________________________|____________|
Trachea | + + + | 3 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
Leukemia Erythrocytic | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
Squamous Cell Papilloma | X X | 2 |
__________________________________________________________________________|____________|
Tooth | + + + + + + | 6 |
Odontoma | X X X X X X | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Leukemia Erythrocytic | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Squamous Cell Papilloma | X | 1 |
Skin, Site of Application, Squamous | | |
Cell Papilloma, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
Leukemia Erythrocytic | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 0| 0| 0| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4| | |
| 1| 1| 1| 3| 9| 2| 4| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 4 |
__________________________________________________________________________|____________|
Gallbladder | A + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 4 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 4 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
Odontoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 4 |
__________________________________________________________________________|____________|
Heart | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + | 4 |
__________________________________________________________________________|____________|
Ovary | + + + + | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 0| 0| 0| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4| | |
| 1| 1| 1| 3| 9| 2| 4| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + | 4 |
__________________________________________________________________________|____________|
Thymus | + + M + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Skin, Site of Application, Squamous | | |
Cell Papilloma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 4 |
__________________________________________________________________________|____________|
Nose | + + + + | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
6 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 4 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
__________________________________________________________________________|____________|
Tooth | + + + + + | 5 |
Odontoma | X X X X X | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + M | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M | 1 |
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
6 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + | 4 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Skin, Site of Application, Squamous | | |
Cell Carcinoma | X | 1 |
Skin, Site of Application, Squamous | | |
Cell Papilloma | X X X | 3 |
Skin, Site of Application, Squamous | | |
Cell Papilloma, Multiple | X X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
6 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
12 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + M M + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Tooth | + + + + + | 5 |
Odontoma | X X X X X | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M M + M M M | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + I + + + + + + + M | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + M + | 9 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:27
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
12 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Squamous Cell Papilloma | X | 1 |
Skin, Site of Application, Squamous | | |
Cell Papilloma | X X X | 3 |
Skin, Site of Application, Squamous | | |
Cell Papilloma, Multiple | X X X X X | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + M + + + + | 9 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
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---------- END OF REPORT ----------
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