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TDMS Study 93021-05 Pathology Tables

NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97
Route: SKIN APPLICATION                                                                                           Time: 10:20:51

                                                       150 DAY SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  538-75-0

       Lock Date:  03/26/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 1| 1| 0| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 0| 4| 4| 5| 4| 4| 8| 4| 4|                                            |            |
                                           | 1| 0| 1| 1| 8| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          2                                                               |      1  2.0|
      Inflammation, Focal                  | 2              2  1                                                      |      3  1.7|
      Necrosis, Focal                      |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +     +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  M                                             |   8        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   2                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 1| 1| 0| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 0| 4| 4| 5| 4| 4| 8| 4| 4|                                            |            |
                                           | 1| 0| 1| 1| 8| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia                          |          2        2  2                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Histiocyte    |    2        2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M                                             |   9        |
      Infiltration Cellular, Histiocyte    |             2                                                            |      1  2.0|
      Necrosis, Focal                      |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 3  2  3  3  2  2        2  2                                             |      8  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +                                             |   9        |
      Atrophy                              |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Synovial Tissue, Inflammation        |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cortex, Cyst                         |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   3                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 1| 1| 1| 1| 1| 1| 1| 1| 0|                                            |            |
                             DAY ON TEST   | 8| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                                           | 4| 1| 1| 1| 1| 1| 1| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    .75                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +              +           +                                             |   3        |
      Inflammation                         |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A              +           +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A              +           +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A              +           +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A              +           +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A              +           +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +           +  +  +     +  +                                             |   6        |
      Fibrosis                             |                3                                                         |      1  3.0|
      Hematopoietic Cell Proliferation     |                         1                                                |      1  1.0|
      Inflammation, Chronic Active, Focal  |             1  4  1                                                      |      3  2.0|
      Necrosis                             |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +        +           +                                             |   4        |
      Inflammation                         |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +        +  +     +        +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +              +           +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M              M           +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M              +           +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +              M           M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +              +           +                                             |   3        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   4                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 1| 1| 1| 1| 1| 1| 1| 1| 0|                                            |            |
                             DAY ON TEST   | 8| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                                           | 4| 1| 1| 1| 1| 1| 1| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    .75                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +              +           +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +              +           +                                             |   3        |
      Myeloid Cell, Hyperplasia            |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   1        |
      Bronchial, Infiltration Cellular,    |                                                                          |            |
           Plasma Cell                     |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +              +           +                                             |   3        |
      Hematopoietic Cell Proliferation     |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +              +           +                                             |   3        |
      Hematopoietic Cell Proliferation     |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +              +  +     +  +                                             |   5        |
      Hematopoietic Cell Proliferation     | 1              4  1     3                                                |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +              +           +                                             |   3        |
      Atrophy                              |                3           3                                             |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +           +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +              +           +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +              +           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +              +           +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +              +           +                                             |   3        |
      Inflammation, Chronic Active         |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +              +           +                                             |   3        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   5                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    1.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +     +  +                                                   |   6        |
      Inflammation, Chronic Active, Focal  |       1     1        1                                                   |      3  1.0|
      Necrosis                             |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                      +     +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +     +        +  +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +                                                                     |   1        |
      Infiltration Cellular, Plasma Cell   |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +              +  +  +  +                                             |   5        |
      Hematopoietic Cell Proliferation     |                   4  2  1  1                                             |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation, Chronic Active    |             2        2  1                                                |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   6                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    1.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   7                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 0| 0| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 3| 9| 2| 4| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    3                                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          A  +  +  +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          A  +  +  +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          A  +  +  +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          A  +  +  +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +  +  +  +  +  +  +                                             |   7        |
      Inflammation, Chronic Active, Focal  |                   1  2  2  1                                             |      4  1.5|
      Necrosis                             |                   1        1                                             |      2  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +              +     +     +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +  +  +                                                      |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +  +  M                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          M  +  +  +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +  +  +                                                      |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +  +  +  +                                                      |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   8                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 0| 0| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 3| 9| 2| 4| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    3                                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +  +  +                                                      |   4        |
      Hyperplasia                          |          2     2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +  +  +                                                      |   4        |
      Hemorrhage                           |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +  +  +                                                      |   4        |
      Necrosis, Focal                      |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +  +  +                                                      |   4        |
      Hematopoietic Cell Proliferation     |          1     3  1                                                      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +  M  +                                                      |   3        |
      Atrophy                              |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M  +  +  +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |                   2                                                      |      1  2.0|
      Dermis, Inflammation, Chronic Active |             2                                                            |      1  2.0|
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation, Chronic Active    | 2     2        2     2     1                                             |      5  1.8|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 2     1     2  2     2     2                                             |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +  +  +                                                      |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +  +  +                                                      |   4        |
      Hemorrhage, Acute                    |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +  +  +                                                      |   4        |
      Hemorrhage, Acute                    |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +  +  +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +  +  +                                                      |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +  +  +                                                      |   4        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   9                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 0| 0| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 3| 9| 2| 4| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    3                                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          A  +  +  +                                                      |   3        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  10                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    6                                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +  +                                                         |   2        |
      Anus, Inflammation                   |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          1                 2                                             |      2  1.5|
      Inflammation, Chronic Active, Focal  | 1  1  1           1  1  1                                                |      6  1.0|
      Necrosis                             |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +  +     +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +           +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +  +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +  M                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             +  M                                                         |   1        |
      Pars Distalis, Necrosis, Focal       |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             +  M                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |             +  +                                                         |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  11                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    6                                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +  +                                                         |   2        |
      Hyperplasia                          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +  +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +  +     +                                                   |   4        |
      Hematopoietic Cell Proliferation     |          2     3     3                                                   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +  +                                                         |   2        |
      Atrophy                              |             4  4                                                         |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +  M                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dermis, Inflammation                 |                2                                                         |      1  2.0|
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation, Chronic Active    | 2  2  2  2  3  3        1  1                                             |      8  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 2  3  1  2  2  3           1                                             |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +  +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +  +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +  +  +                                                      |   5        |
      Inflammation                         | 1        1        1                                                      |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +  +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |             +  +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +  +                                                         |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  12                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 0| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    12                                     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +  +  M  M  +                                             |   7        |
      Inflammation                         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Fibrosis                             |                   2                                                      |      1  2.0|
      Hematopoietic Cell Proliferation     |       2                                                                  |      1  2.0|
      Inflammation, Chronic Active, Focal  | 1                    2                                                   |      2  1.5|
      Inflammation, Focal                  |       3  1  3  2           2                                             |      5  2.2|
      Necrosis, Focal                      |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         |             1                                                            |      1  1.0|
      Serosa, Fibrosis                     |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +                 +  +                                             |   5        |
      Inflammation, Chronic Active         |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Acute                  |                         2                                                |      1  2.0|
      Mineralization, Focal                |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M  M  M  +  M  M  M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  +  +  +  +  +  +  M                                             |   8        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  13                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 0| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    12                                     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +                                             |   9        |
      Inflammation                         |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  M  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                2                                                         |      1  2.0|
      Bilateral, Cyst                      |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia                          |       3                 2                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Plasma Cell   |       2                                                                  |      1  2.0|
      Infiltration Cellular, Histiocyte    |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Fibrosis                             |                   3                                                      |      1  3.0|
      Hematopoietic Cell Proliferation     |    2  3  1  2  2  2  2  2  2                                             |      9  2.0|
      Lymphoid Follicle, Depletion Cellular|                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                         4                                                |      1  4.0|
      Hemorrhage                           |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia                          |             1                                                            |      1  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                         +                                                |   1        |
      Inflammation                         |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  14                                                               
NTP Experiment-Test: 93021-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:20:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 0| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    12                                     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                   1  2  1  1                                             |      4  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         |                   3                                                      |      1  3.0|
      Respiratory Epithelium, Inflammation |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  M  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Inflammation              |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  15                                                               
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                             ----------              END OF REPORT             ----------                                           
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