TDMS Study 93027-47 Pathology Tables
NTP Experiment-Test: 93027-47 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:47:13 13 WEEK SUBCHRONIC Facility: Battelle Columbus Laboratory Chemical CAS #: 94-75-7 Lock Date: 06/12/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93027-47 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:47:13 ____________________________________________________________________________________________________________________________________ SYRIAN HAMSTERS MALE 0 PPM 12 PPM 100 PPM 500 PPM 1000 PPM 5000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (10) (10) Infiltration Cellular, Mixed Cell 8 (80%) 8 (80%) Liver (10) (10) (10) (10) (9) (10) Infiltration Cellular, Mixed Cell 10 (100%) 10 (100%) 9 (90%) 8 (80%) 9 (100%) 10 (100%) Necrosis, Focal 1 (10%) Vacuolization Cytoplasmic, Focal 1 (10%) Pancreas (10) (10) (10) (10) (10) (10) Inflammation, Chronic 7 (70%) 9 (90%) 9 (90%) 7 (70%) 7 (70%) 9 (90%) Stomach, Glandular (10) (10) Mineralization 5 (50%) 7 (70%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) Cardiomyopathy 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (7) (2) (10) Atrophy 2 (100%) Preputial Gland (5) (2) (2) (2) (4) (3) Inflammation 1 (50%) Prostate (10) (10) Atrophy 3 (30%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-47 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:47:13 ____________________________________________________________________________________________________________________________________ SYRIAN HAMSTERS MALE 0 PPM 12 PPM 100 PPM 500 PPM 1000 PPM 5000 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Seminal Vesicle (10) (10) Atrophy 3 (30%) Testes (10) (10) (9) (10) (10) (10) Atrophy 3 (30%) 2 (20%) 2 (22%) 5 (50%) 3 (30%) 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Hemorrhage 2 (20%) 1 (10%) Inflammation, Chronic 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (9) (10) (10) (10) Mineralization 4 (40%) 7 (70%) 6 (67%) 7 (70%) 8 (80%) 8 (80%) Nephropathy 3 (30%) 6 (60%) 5 (56%) 7 (70%) 3 (30%) 8 (80%) Urinary Bladder (10) (9) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-47 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:47:13 ____________________________________________________________________________________________________________________________________ SYRIAN HAMSTERS MALE 0 PPM 12 PPM 100 PPM 500 PPM 1000 PPM 5000 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Mineralization 5 (50%) 5 (56%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------