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TDMS Study 50215-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                       ACRYLONITRILE                                     DATE: 10/31/00       
EXPERIMENT: 50215 TEST: 03                                                                                     TIME: 12:42:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55388                              ROUTE: GAVAGE                                                  NTP C#: 50215B       
PATHOLOGIST: MISSING                                                                                           CAS: 107-13-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            MICE FINAL#1                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                       ACRYLONITRILE                                     DATE: 10/31/00       
EXPERIMENT: 50215 TEST: 03                                                                                     TIME: 12:42:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: GAVAGE                                                  NTP C#: 50215B       
PATHOLOGIST: MISSING                                                                                           CAS: 107-13-1        
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                       ACRYLONITRILE                                     DATE: 10/31/00       
EXPERIMENT: 50215 TEST: 03                                                                                     TIME: 12:42:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: GAVAGE                                                  NTP C#: 50215B       
PATHOLOGIST: MISSING                                                                                           CAS: 107-13-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  ACRYLONITRILE                                                                                   
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Harderian Gland                        Adenoma                                                                                      
                                       Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Stomach, Forestomach                   Squamous Cell Carcinoma                                                                      
                                       Squamous Cell Carcinoma or Papilloma Squamous                                                
                                       Squamous Cell Papilloma                                                                      
All Organs                             Hemangiosarcoma or Hemangioma                                                                
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Harderian Gland                        Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Liver                                  Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Ovary                                  Cystadenoma                                                                                  
                                       Hemangioma                                                                                   
Stomach, Forestomach                   Squamous Cell Carcinoma                                                                      
                                       Squamous Cell Carcinoma or Papilloma Squamous                                                
                                       Squamous Cell Papilloma                                                                      
All Organs                             Hemangioma                                                                                   
                                       Hemangiosarcoma                                                                              
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                   ACRYLONITRILE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    4/50 (8%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.19      0/46.03      4/45.96      0/30.48     |0/46.90      0/44.06      0/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         8.7%         0.0%        |0.0%         0.0%         0.0%         2.8%         | 
|TERMINAL (d)       |     3/38 (8%)    0/42 (0%)    3/39 (8%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     730 (T)      ---          497          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.561N     P=0.104N     P=0.512      P=0.341N    |P=0.131      (e)          (e)          P=0.395      | 
|POLY 3             |     P=0.512N     P=0.119N     P=0.497      P=0.212N    |P=0.168      (e)          (e)          P=0.444      | 
|POLY 1.5           |     P=0.418N     P=0.122N     P=0.495      P=0.178N    |P=0.165      (e)          (e)          P=0.460      | 
|POLY 6             |     P=0.597      P=0.115N     P=0.502      P=0.251N    |P=0.179      (e)          (e)          P=0.429      | 
|LOGISTIC REGRESSION|     P=0.351N     (e)          P=0.505      (e)         |(e)          (e)          (e)          P=0.395      | 
|COCH-ARM / FISHERS |     P=0.279N     P=0.121N     P=0.500      P=0.121N    |P=0.188      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      2/46.74      0/45.28      1/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         3.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    1/14 (7%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          518          ---          730 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476      P=0.243      (e)          P=0.301     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.570      P=0.240      (e)          P=0.420     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.568      P=0.235      (e)          P=0.445     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.582      P=0.246      (e)          P=0.395     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.653N     P=0.269      (e)          P=0.301     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.628      P=0.247      (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.69      0/46.03      0/45.28      0/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     582          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.214N     P=0.233N     P=0.244N     P=0.422N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.157N     P=0.240N     P=0.244N     P=0.342N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.145N     P=0.243N     P=0.243N     P=0.306N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.169N     P=0.237N     P=0.245N     P=0.382N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.131N     P=0.213N     P=0.205N     P=0.240N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.152N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   16/50 (32%)  24/50 (48%)  27/50 (54%) |10/50 (20%)  10/50 (20%)  25/50 (50%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     5/46.19      16/46.99     24/48.52     27/36.28    |10/47.80     10/44.76     25/47.71     23/37.23     | 
|POLY-3 PERCENT (g) |     10.8%        34.1%        49.5%        74.4%       |20.9%        22.3%        52.4%        61.8%        | 
|TERMINAL (d)       |     5/38 (13%)   13/42 (31%)  16/39 (41%)  12/14 (86%) |9/39 (23%)   8/32 (25%)   22/39 (56%)  15/23 (65%)  | 
|FIRST INCIDENCE    |     730 (T)      518          497          477         |338          563          639          547          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.424      P=0.002 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.535      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.558      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.008 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.509      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.597N     P=0.002 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.598N     P=0.002 **   P=0.005 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    4/50 (8%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.19      1/46.03      4/45.96      3/31.12     |1/46.90      0/44.06      3/47.08      2/35.27      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         8.7%         9.6%        |2.1%         0.0%         6.4%         5.7%         | 
|TERMINAL (d)       |     1/38 (3%)    1/42 (2%)    3/39 (8%)    0/14 (0%)   |1/39 (3%)    0/32 (0%)    2/39 (5%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      497          554         |729 (T)      ---          711          711          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    P=0.739N     P=0.188      P=0.094     |P=0.096      P=0.539N     P=0.315      P=0.330      | 
|POLY 3             |     P=0.053      P=0.760      P=0.177      P=0.184     |P=0.115      P=0.512N     P=0.307      P=0.403      | 
|POLY 1.5           |     P=0.071      P=0.756      P=0.176      P=0.217     |P=0.131      P=0.507N     P=0.305      P=0.430      | 
|POLY 6             |     P=0.041 *    P=0.757N     P=0.180      P=0.155     |P=0.105      P=0.519N     P=0.310      P=0.378      | 
|LOGISTIC REGRESSION|     P=0.096      P=0.739N     P=0.189      P=0.196     |P=0.104      (e)          P=0.310      P=0.351      | 
|COCH-ARM / FISHERS |     P=0.143      P=0.753N     P=0.181      P=0.309     |P=0.193      P=0.500N     P=0.309      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   16/50 (32%)  27/50 (54%)  30/50 (60%) |11/50 (22%)  10/50 (20%)  26/50 (52%)  25/50 (50%)  | 
|POLY-3 RATE (b)    |     6/46.19      16/46.99     27/48.52     30/36.92    |11/47.80     10/44.76     26/47.71     25/37.30     | 
|POLY-3 PERCENT (g) |     13.0%        34.1%        55.6%        81.3%       |23.0%        22.3%        54.5%        67.0%        | 
|TERMINAL (d)       |     6/38 (16%)   13/42 (31%)  19/39 (49%)  12/14 (86%) |10/39 (26%)  8/32 (25%)   23/39 (59%)  16/23 (70%)  | 
|FIRST INCIDENCE    |     730 (T)      518          497          477         |338          563          639          547          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.028 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.514      P=0.002 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.568N     P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.543N     P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.017 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.594N     P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.013 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.502N     P=0.002 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.500N     P=0.002 **   P=0.003 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Duodenum                                                                                                        | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.44      3/46.03      0/45.28      0/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     2.2%         6.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    3/42 (7%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     664          730 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.185N     P=0.338      P=0.500N     P=0.625N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.135N     P=0.302      P=0.505N     P=0.581N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.118N     P=0.298      P=0.504N     P=0.555N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.153N     P=0.308      P=0.505N     P=0.606N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.134N     P=0.301      P=0.480N     P=0.534N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.097N     P=0.309      P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.19      1/46.03      0/45.28      0/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.178N     P=0.465N     P=0.233N     P=0.475N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.122N     P=0.501N     P=0.242N     P=0.340N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.110N     P=0.507N     P=0.241N     P=0.305N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.134N     P=0.494N     P=0.241N     P=0.377N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.178N     P=0.465N     (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.104N     P=0.500N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.19      1/46.03      0/45.28      0/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.178N     P=0.465N     P=0.233N     P=0.475N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.122N     P=0.501N     P=0.242N     P=0.340N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.110N     P=0.507N     P=0.241N     P=0.305N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.134N     P=0.494N     P=0.241N     P=0.377N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.178N     P=0.465N     (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.104N     P=0.500N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.44      3/46.03      0/45.28      0/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     2.2%         6.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    3/42 (7%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     664          730 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.185N     P=0.338      P=0.500N     P=0.625N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.135N     P=0.302      P=0.505N     P=0.581N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.118N     P=0.298      P=0.504N     P=0.555N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.153N     P=0.308      P=0.505N     P=0.606N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.134N     P=0.301      P=0.480N     P=0.534N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.097N     P=0.309      P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.19      0/46.03      2/45.82      0/30.48     |0/46.90      1/44.60      1/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         4.4%         0.0%        |0.0%         2.2%         2.1%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      ---          626          ---         |---          563          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.511N     P=0.217N     P=0.687N     P=0.475N    |P=0.620N     P=0.496      P=0.500      (e)          | 
|POLY 3             |     P=0.467N     P=0.238N     P=0.691      P=0.340N    |P=0.618N     P=0.490      P=0.500      (e)          | 
|POLY 1.5           |     P=0.401N     P=0.242N     P=0.689      P=0.305N    |P=0.590N     P=0.494      P=0.500      (e)          | 
|POLY 6             |     P=0.537N     P=0.233N     P=0.692N     P=0.377N    |P=0.649N     P=0.485      P=0.502      (e)          | 
|LOGISTIC REGRESSION|     P=0.358N     (e)          P=0.690N     (e)         |P=0.499N     P=0.551      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.313N     P=0.247N     P=0.691N     P=0.247N    |P=0.545N     P=0.500      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.19      1/46.03      2/45.28      2/30.48     |2/46.90      1/44.06      1/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         4.4%         6.6%        |4.3%         2.3%         2.1%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    1/42 (2%)    2/39 (5%)    2/14 (14%)  |2/39 (5%)    1/32 (3%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      730 (T)      730 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.152      P=0.465N     P=0.686N     P=0.312     |P=0.229N     P=0.569N     P=0.500N     P=0.361N     | 
|POLY 3             |     P=0.347      P=0.501N     P=0.687      P=0.536     |P=0.201N     P=0.522N     P=0.499N     P=0.306N     | 
|POLY 1.5           |     P=0.379      P=0.507N     P=0.687      P=0.588     |P=0.189N     P=0.513N     P=0.501N     P=0.285N     | 
|POLY 6             |     P=0.323      P=0.494N     P=0.688      P=0.482     |P=0.214N     P=0.533N     P=0.497N     P=0.327N     | 
|LOGISTIC REGRESSION|     P=0.152      P=0.465N     P=0.686N     P=0.312     |P=0.229N     P=0.569N     P=0.500N     (e)          | 
|COCH-ARM / FISHERS |     P=0.488      P=0.500N     P=0.691N     P=0.691N    |P=0.165N     P=0.500N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  32/50 (64%)  29/50 (58%)  14/50 (28%) |14/50 (28%)  14/50 (28%)  15/50 (30%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     23/47.35     32/46.03     29/46.30     14/33.16    |14/46.90     14/44.74     15/47.06     10/36.44     | 
|POLY-3 PERCENT (g) |     48.6%        69.5%        62.6%        42.2%       |29.9%        31.3%        31.9%        27.5%        | 
|TERMINAL (d)       |     20/38 (53%)  32/42 (76%)  26/39 (67%)  6/14 (43%)  |14/39 (36%)  10/32 (31%)  14/39 (36%)  7/23 (30%)   | 
|FIRST INCIDENCE    |     607          730 (T)      563          505         |729 (T)      640          716          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.075      P=0.122      P=0.183      P=0.131     |P=0.430      P=0.359      P=0.502      P=0.409      | 
|POLY 3             |     P=0.222N     P=0.029 *    P=0.119      P=0.370N    |P=0.451N     P=0.531      P=0.504      P=0.501N     | 
|POLY 1.5           |     P=0.089N     P=0.029 *    P=0.127      P=0.226N    |P=0.383N     P=0.553      P=0.498      P=0.424N     | 
|POLY 6             |     P=0.415N     P=0.028 *    P=0.115      P=0.538N    |P=0.505N     P=0.507      P=0.516      P=0.570N     | 
|LOGISTIC REGRESSION|     P=0.329N     P=0.053      P=0.127      P=0.425N    |P=0.528N     P=0.438      P=0.537      P=0.573N     | 
|COCH-ARM / FISHERS |     P=0.005N**   P=0.054      P=0.158      P=0.048N*   |P=0.201N     P=0.588N     P=0.500      P=0.241N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  10/50 (20%)  17/50 (34%)  6/50 (12%)  |7/50 (14%)   3/50 (6%)    6/50 (12%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     14/48.23     10/47.29     17/47.14     6/30.62     |7/47.11      3/44.06      6/47.06      2/35.38      | 
|POLY-3 PERCENT (g) |     29.0%        21.1%        36.1%        19.6%       |14.9%        6.8%         12.8%        5.7%         | 
|TERMINAL (d)       |     9/38 (24%)   6/42 (14%)   11/39 (28%)  3/14 (21%)  |6/39 (15%)   3/32 (9%)    5/39 (13%)   1/23 (4%)    | 
|FIRST INCIDENCE    |     464          535          515          715         |673          729 (T)      715          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.295      P=0.202N     P=0.355      P=0.597N    |P=0.318N     P=0.247N     P=0.496N     P=0.265N     | 
|POLY 3             |     P=0.541      P=0.258N     P=0.304      P=0.259N    |P=0.253N     P=0.186N     P=0.501N     P=0.170N     | 
|POLY 1.5           |     P=0.358N     P=0.268N     P=0.307      P=0.155N    |P=0.220N     P=0.174N     P=0.503N     P=0.139N     | 
|POLY 6             |     P=0.374      P=0.242N     P=0.309      P=0.396N    |P=0.282N     P=0.202N     P=0.497N     P=0.203N     | 
|LOGISTIC REGRESSION|     P=0.230N     P=0.225N     P=0.358      P=0.186N    |P=0.280N     P=0.212N     P=0.490N     P=0.194N     | 
|COCH-ARM / FISHERS |     P=0.092N     P=0.241N     P=0.333      P=0.039N*   |P=0.142N     P=0.159N     P=0.500N     P=0.080N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  10/50 (20%)  17/50 (34%)  6/50 (12%)  |7/50 (14%)   3/50 (6%)    6/50 (12%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     14/48.23     10/47.29     17/47.14     6/30.62     |7/47.11      3/44.06      6/47.06      2/35.38      | 
|POLY-3 PERCENT (g) |     29.0%        21.1%        36.1%        19.6%       |14.9%        6.8%         12.8%        5.7%         | 
|TERMINAL (d)       |     9/38 (24%)   6/42 (14%)   11/39 (28%)  3/14 (21%)  |6/39 (15%)   3/32 (9%)    5/39 (13%)   1/23 (4%)    | 
|FIRST INCIDENCE    |     464          535          515          715         |673          729 (T)      715          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.295      P=0.202N     P=0.355      P=0.597N    |P=0.318N     P=0.247N     P=0.496N     P=0.265N     | 
|POLY 3             |     P=0.541      P=0.258N     P=0.304      P=0.259N    |P=0.253N     P=0.186N     P=0.501N     P=0.170N     | 
|POLY 1.5           |     P=0.358N     P=0.268N     P=0.307      P=0.155N    |P=0.220N     P=0.174N     P=0.503N     P=0.139N     | 
|POLY 6             |     P=0.374      P=0.242N     P=0.309      P=0.396N    |P=0.282N     P=0.202N     P=0.497N     P=0.203N     | 
|LOGISTIC REGRESSION|     P=0.230N     P=0.225N     P=0.358      P=0.186N    |P=0.280N     P=0.212N     P=0.490N     P=0.194N     | 
|COCH-ARM / FISHERS |     P=0.092N     P=0.241N     P=0.333      P=0.039N*   |P=0.142N     P=0.159N     P=0.500N     P=0.080N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     32/50 (64%)  36/50 (72%)  37/50 (74%)  17/50 (34%) |20/50 (40%)  15/50 (30%)  19/50 (38%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     32/48.99     36/47.29     37/47.14     17/33.21    |20/47.11     15/44.74     19/47.11     10/36.44     | 
|POLY-3 PERCENT (g) |     65.3%        76.1%        78.5%        51.2%       |42.5%        33.5%        40.3%        27.5%        | 
|TERMINAL (d)       |     25/38 (66%)  32/42 (76%)  31/39 (80%)  8/14 (57%)  |19/39 (49%)  11/32 (34%)  17/39 (44%)  7/23 (30%)   | 
|FIRST INCIDENCE    |     464          535          515          505         |673          640          715          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095      P=0.497      P=0.258      P=0.228     |P=0.359N     P=0.439N     P=0.495N     P=0.357N     | 
|POLY 3             |     P=0.157N     P=0.172      P=0.109      P=0.145N    |P=0.183N     P=0.251N     P=0.500N     P=0.117N     | 
|POLY 1.5           |     P=0.031N*    P=0.168      P=0.128      P=0.048N*   |P=0.135N     P=0.230N     P=0.506N     P=0.078N     | 
|POLY 6             |     P=0.427N     P=0.182      P=0.097      P=0.333N    |P=0.228N     P=0.277N     P=0.490N     P=0.163N     | 
|LOGISTIC REGRESSION|     P=0.073N     P=0.213      P=0.163      P=0.110N    |P=0.238N     P=0.335N     P=0.452N     P=0.165N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.260      P=0.194      P=0.002N**  |P=0.044N*    P=0.201N     P=0.500N     P=0.024N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     32/50 (64%)  36/50 (72%)  37/50 (74%)  17/50 (34%) |20/50 (40%)  15/50 (30%)  19/50 (38%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     32/48.99     36/47.29     37/47.14     17/33.21    |20/47.11     15/44.74     19/47.11     10/36.44     | 
|POLY-3 PERCENT (g) |     65.3%        76.1%        78.5%        51.2%       |42.5%        33.5%        40.3%        27.5%        | 
|TERMINAL (d)       |     25/38 (66%)  32/42 (76%)  31/39 (80%)  8/14 (57%)  |19/39 (49%)  11/32 (34%)  17/39 (44%)  7/23 (30%)   | 
|FIRST INCIDENCE    |     464          535          515          505         |673          640          715          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095      P=0.497      P=0.258      P=0.228     |P=0.359N     P=0.439N     P=0.495N     P=0.357N     | 
|POLY 3             |     P=0.157N     P=0.172      P=0.109      P=0.145N    |P=0.183N     P=0.251N     P=0.500N     P=0.117N     | 
|POLY 1.5           |     P=0.031N*    P=0.168      P=0.128      P=0.048N*   |P=0.135N     P=0.230N     P=0.506N     P=0.078N     | 
|POLY 6             |     P=0.427N     P=0.182      P=0.097      P=0.333N    |P=0.228N     P=0.277N     P=0.490N     P=0.163N     | 
|LOGISTIC REGRESSION|     P=0.073N     P=0.213      P=0.163      P=0.110N    |P=0.238N     P=0.335N     P=0.452N     P=0.165N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.260      P=0.194      P=0.002N**  |P=0.044N*    P=0.201N     P=0.500N     P=0.024N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  9/50 (18%)   4/50 (8%)    8/50 (16%)  |4/50 (8%)    1/50 (2%)    8/50 (16%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     10/46.26     9/46.03      4/45.28      8/31.04     |4/47.01      1/44.41      8/47.47      5/35.43      | 
|POLY-3 PERCENT (g) |     21.6%        19.6%        8.8%         25.8%       |8.5%         2.3%         16.9%        14.1%        | 
|TERMINAL (d)       |     9/38 (24%)   9/42 (21%)   4/39 (10%)   4/14 (29%)  |3/39 (8%)    0/32 (0%)    5/39 (13%)   4/23 (17%)   | 
|FIRST INCIDENCE    |     714          730 (T)      730 (T)      642         |701          633          639          667          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.145      P=0.406N     P=0.068N     P=0.088     |P=0.044 *    P=0.239N     P=0.192      P=0.210      | 
|POLY 3             |     P=0.469N     P=0.505N     P=0.078N     P=0.443     |P=0.062      P=0.196N     P=0.182      P=0.330      | 
|POLY 1.5           |     P=0.409N     P=0.519N     P=0.078N     P=0.559     |P=0.080      P=0.189N     P=0.178      P=0.377      | 
|POLY 6             |     P=0.512N     P=0.485N     P=0.076N     P=0.333     |P=0.052      P=0.206N     P=0.188      P=0.289      | 
|LOGISTIC REGRESSION|     P=0.310      P=0.448N     P=0.073N     P=0.231     |P=0.069      P=0.182N     P=0.177      P=0.268      | 
|COCH-ARM / FISHERS |     P=0.270N     P=0.500N     P=0.074N     P=0.398N    |P=0.161      P=0.181N     P=0.178      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    5/50 (10%)   2/50 (4%)   |2/50 (4%)    5/50 (10%)   6/50 (12%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/47.35      2/46.80      5/45.82      2/30.80     |2/47.18      5/44.83      6/47.31      4/35.38      | 
|POLY-3 PERCENT (g) |     8.5%         4.3%         10.9%        6.5%        |4.2%         11.2%        12.7%        11.3%        | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    4/39 (10%)   1/14 (7%)   |0/39 (0%)    1/32 (3%)    5/39 (13%)   3/23 (13%)   | 
|FIRST INCIDENCE    |     617          535          563          642         |677          647          645          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.370      P=0.331N     P=0.493      P=0.661N    |P=0.174      P=0.167      P=0.144      P=0.149      | 
|POLY 3             |     P=0.461      P=0.343N     P=0.479      P=0.544N    |P=0.203      P=0.196      P=0.134      P=0.218      | 
|POLY 1.5           |     P=0.540      P=0.348N     P=0.485      P=0.477N    |P=0.242      P=0.204      P=0.133      P=0.250      | 
|POLY 6             |     P=0.387      P=0.337N     P=0.474      P=0.612N    |P=0.173      P=0.187      P=0.136      P=0.191      | 
|LOGISTIC REGRESSION|     P=0.419N     P=0.274N     P=0.538      P=0.393N    |P=0.259      P=0.228      P=0.134      P=0.206      | 
|COCH-ARM / FISHERS |     P=0.418N     P=0.339N     P=0.500      P=0.339N    |P=0.380      P=0.218      P=0.134      P=0.339      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  11/50 (22%)  8/50 (16%)   9/50 (18%)  |6/50 (12%)   6/50 (12%)   14/50 (28%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     14/47.41     11/46.80     8/45.82      9/31.04     |6/47.29      6/45.18      14/47.77     9/35.62      | 
|POLY-3 PERCENT (g) |     29.5%        23.5%        17.5%        29.0%       |12.7%        13.3%        29.3%        25.3%        | 
|TERMINAL (d)       |     9/38 (24%)   9/42 (21%)   7/39 (18%)   5/14 (36%)  |3/39 (8%)    1/32 (3%)    10/39 (26%)  7/23 (30%)   | 
|FIRST INCIDENCE    |     617          535          563          642         |677          633          639          667          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.219      P=0.257N     P=0.120N     P=0.198     |P=0.020 *    P=0.502      P=0.052      P=0.055      | 
|POLY 3             |     P=0.399N     P=0.335N     P=0.129N     P=0.578N    |P=0.029 *    P=0.588      P=0.039 *    P=0.121      | 
|POLY 1.5           |     P=0.305N     P=0.347N     P=0.125N     P=0.430N    |P=0.045 *    P=0.600      P=0.038 *    P=0.160      | 
|POLY 6             |     P=0.484N     P=0.323N     P=0.133N     P=0.465     |P=0.019 *    P=0.575      P=0.042 *    P=0.091      | 
|LOGISTIC REGRESSION|     P=0.450N     P=0.333N     P=0.118N     P=0.539     |P=0.043 *    P=0.612N     P=0.040 *    P=0.090      | 
|COCH-ARM / FISHERS |     P=0.138N     P=0.322N     P=0.114N     P=0.171N    |P=0.138      P=0.620N     P=0.039 *    P=0.288      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.22      1/46.03      0/45.28      0/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     723          730 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.177N     P=0.471N     P=0.240N     P=0.458N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.122N     P=0.501N     P=0.242N     P=0.340N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.110N     P=0.507N     P=0.241N     P=0.305N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.134N     P=0.494N     P=0.241N     P=0.378N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.159N     P=0.486N     P=0.239N     P=0.407N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.104N     P=0.500N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |8/50 (16%)   4/50 (8%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |8/47.16      4/44.06      2/47.00      3/35.29      | 
|POLY-3 PERCENT (g) |                                                        |17.0%        9.1%         4.3%         8.5%         | 
|TERMINAL (d)       |                                                        |7/39 (18%)   4/32 (13%)   2/39 (5%)    2/23 (9%)    | 
|FIRST INCIDENCE    |                                                        |659          729 (T)      729 (T)      704          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.194N     P=0.283N     P=0.049N*    P=0.340N     | 
|POLY 3             |                                                        |P=0.112N     P=0.211N     P=0.046N*    P=0.219N     | 
|POLY 1.5           |                                                        |P=0.104N     P=0.197N     P=0.046N*    P=0.177N     | 
|POLY 6             |                                                        |P=0.116N     P=0.231N     P=0.045N*    P=0.263N     | 
|LOGISTIC REGRESSION|                                                        |P=0.171N     P=0.241N     P=0.046N*    P=0.268N     | 
|COCH-ARM / FISHERS |                                                        |P=0.080N     P=0.178N     P=0.046N*    P=0.100N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor Benign                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.90      0/44.06      3/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         6.4%         2.8%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/32 (0%)    3/39 (8%)    1/23 (4%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.114      (e)          P=0.121      P=0.395      | 
|POLY 3             |                                                        |P=0.109      (e)          P=0.119      P=0.444      | 
|POLY 1.5           |                                                        |P=0.129      (e)          P=0.119      P=0.460      | 
|POLY 6             |                                                        |P=0.094      (e)          P=0.120      P=0.429      | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.121      P=0.395      | 
|COCH-ARM / FISHERS |                                                        |P=0.209      (e)          P=0.121      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.90      0/44.06      4/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         8.5%         2.8%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/32 (0%)    4/39 (10%)   1/23 (4%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.102      (e)          P=0.063      P=0.395      | 
|POLY 3             |                                                        |P=0.090      (e)          P=0.061      P=0.444      | 
|POLY 1.5           |                                                        |P=0.113      (e)          P=0.060      P=0.460      | 
|POLY 6             |                                                        |P=0.074      (e)          P=0.061      P=0.429      | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.063      P=0.395      | 
|COCH-ARM / FISHERS |                                                        |P=0.201      (e)          P=0.059      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.90      0/44.06      1/47.00      2/35.55      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         2.1%         5.6%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/32 (0%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          729 (T)      660          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.030 *    (e)          P=0.500      P=0.153      | 
|POLY 3             |                                                        |P=0.042 *    (e)          P=0.500      P=0.182      | 
|POLY 1.5           |                                                        |P=0.045 *    (e)          P=0.500      P=0.196      | 
|POLY 6             |                                                        |P=0.042 *    (e)          P=0.502      P=0.170      | 
|LOGISTIC REGRESSION|                                                        |P=0.043 *    (e)          P=0.500      P=0.198      | 
|COCH-ARM / FISHERS |                                                        |P=0.062      (e)          P=0.500      P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/46 (0%)    0/47 (0%)    0/47 (0%)   |2/48 (4%)    4/49 (8%)    4/48 (8%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.19      0/42.03      0/42.45      0/28.82     |2/44.90      4/44.18      4/45.36      2/35.08      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         9.1%         8.8%         5.7%         | 
|TERMINAL (d)       |     0/37 (0%)    0/38 (0%)    0/37 (0%)    0/14 (0%)   |2/37 (5%)    2/32 (6%)    3/38 (8%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      653          646          640          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.503      P=0.277      P=0.347      P=0.529      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.529      P=0.330      P=0.342      P=0.601      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.564N     P=0.337      P=0.338      P=0.630      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.502      P=0.319      P=0.348      P=0.577      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.569N     P=0.324      P=0.337      P=0.606      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.456N     P=0.349      P=0.339      P=0.684N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    5/50 (10%)   4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/46.19      1/46.03      0/45.28      0/30.48     |3/47.44      5/44.65      4/47.45      3/36.24      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |6.3%         11.2%        8.4%         8.3%         | 
|TERMINAL (d)       |     0/38 (0%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |1/39 (3%)    2/32 (6%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      ---          ---         |653          640          646          555          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.605N     P=0.520      (e)          (e)         |P=0.493      P=0.278      P=0.504      P=0.462      | 
|POLY 3             |     P=0.505N     P=0.499      (e)          (e)         |P=0.539      P=0.324      P=0.500      P=0.533      | 
|POLY 1.5           |     P=0.473N     P=0.496      (e)          (e)         |P=0.544N     P=0.337      P=0.498      P=0.570      | 
|POLY 6             |     P=0.539N     P=0.504      (e)          (e)         |P=0.513      P=0.308      P=0.503      P=0.500      | 
|LOGISTIC REGRESSION|     (e)          P=0.520      (e)          (e)         |P=0.448N     P=0.371      P=0.507      P=0.667N     | 
|COCH-ARM / FISHERS |     P=0.468N     P=0.500      (e)          (e)         |P=0.440N     P=0.357      P=0.500      P=0.661N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    3/50 (6%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.19      1/46.03      0/45.28      0/30.48     |2/47.18      3/44.33      3/47.45      2/36.05      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |4.2%         6.8%         6.3%         5.6%         | 
|TERMINAL (d)       |     0/38 (0%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |1/39 (3%)    1/32 (3%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      ---          ---         |653          694          646          555          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.605N     P=0.520      (e)          (e)         |P=0.480      P=0.419      P=0.507      P=0.539      | 
|POLY 3             |     P=0.505N     P=0.499      (e)          (e)         |P=0.509      P=0.472      P=0.503      P=0.593      | 
|POLY 1.5           |     P=0.473N     P=0.496      (e)          (e)         |P=0.540      P=0.483      P=0.500      P=0.622      | 
|POLY 6             |     P=0.539N     P=0.504      (e)          (e)         |P=0.488      P=0.457      P=0.507      P=0.566      | 
|LOGISTIC REGRESSION|     (e)          P=0.520      (e)          (e)         |P=0.519N     P=0.500      P=0.507      P=0.689N     | 
|COCH-ARM / FISHERS |     P=0.468N     P=0.500      (e)          (e)         |P=0.521N     P=0.500      P=0.500      P=0.691N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    5/50 (10%)   4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/46.19      1/46.03      0/45.28      0/30.48     |3/47.44      5/44.65      4/47.45      3/36.24      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |6.3%         11.2%        8.4%         8.3%         | 
|TERMINAL (d)       |     0/38 (0%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |1/39 (3%)    2/32 (6%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      ---          ---         |653          640          646          555          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.605N     P=0.520      (e)          (e)         |P=0.493      P=0.278      P=0.504      P=0.462      | 
|POLY 3             |     P=0.505N     P=0.499      (e)          (e)         |P=0.539      P=0.324      P=0.500      P=0.533      | 
|POLY 1.5           |     P=0.473N     P=0.496      (e)          (e)         |P=0.544N     P=0.337      P=0.498      P=0.570      | 
|POLY 6             |     P=0.539N     P=0.504      (e)          (e)         |P=0.513      P=0.308      P=0.503      P=0.500      | 
|LOGISTIC REGRESSION|     (e)          P=0.520      (e)          (e)         |P=0.448N     P=0.371      P=0.507      P=0.667N     | 
|COCH-ARM / FISHERS |     P=0.468N     P=0.500      (e)          (e)         |P=0.440N     P=0.357      P=0.500      P=0.661N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    8/50 (16%)   9/50 (18%)  |0/50 (0%)    1/50 (2%)    1/50 (2%)    11/50 (22%)  | 
|POLY-3 RATE (b)    |     0/46.19      0/46.03      8/46.58      9/33.02     |0/46.90      1/44.30      1/47.33      11/37.19     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         17.2%        27.3%       |0.0%         2.3%         2.1%         29.6%        | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    4/39 (10%)   0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    3/23 (13%)   | 
|FIRST INCIDENCE    |     ---          ---          515          525         |---          665          639          513          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.006 **   P<0.001 **  |P<0.001 **   P=0.477      P=0.504      P<0.001 **   | 
|POLY 3             |     P<0.001 **   (e)          P=0.004 **   P<0.001 **  |P<0.001 **   P=0.489      P=0.502      P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.004 **   P<0.001 **  |P<0.001 **   P=0.493      P=0.500      P<0.001 **   | 
|POLY 6             |     P<0.001 **   (e)          P=0.004 **   P<0.001 **  |P<0.001 **   P=0.483      P=0.504      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.006 **   P<0.001 **  |P<0.001 **   P=0.519      P=0.520      P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.003 **   P<0.001 **  |P<0.001 **   P=0.500      P=0.500      P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    26/50 (52%)  32/50 (64%) |3/50 (6%)    7/50 (14%)   25/50 (50%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     3/46.94      4/46.03      26/46.66     32/38.42    |3/46.90      7/44.46      25/47.42     29/38.47     | 
|POLY-3 PERCENT (g) |     6.4%         8.7%         55.7%        83.3%       |6.4%         15.7%        52.7%        75.4%        | 
|TERMINAL (d)       |     2/38 (5%)    4/42 (10%)   21/39 (54%)  12/14 (86%) |3/39 (8%)    5/32 (16%)   22/39 (56%)  17/23 (74%)  | 
|FIRST INCIDENCE    |     464          730 (T)      515          410         |729 (T)      665          639          513          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.543      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.097      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.489      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.136      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.484      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.145      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.498      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.126      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.505      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.123      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.159      P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    19/50 (38%)  25/50 (50%) |3/50 (6%)    6/50 (12%)   24/50 (48%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |     3/46.94      4/46.03      19/45.36     25/35.98    |3/46.90      6/44.22      24/47.09     19/36.73     | 
|POLY-3 PERCENT (g) |     6.4%         8.7%         41.9%        69.5%       |6.4%         13.6%        51.0%        51.7%        | 
|TERMINAL (d)       |     2/38 (5%)    4/42 (10%)   18/39 (46%)  12/14 (86%) |3/39 (8%)    5/32 (16%)   22/39 (56%)  14/23 (61%)  | 
|FIRST INCIDENCE    |     464          730 (T)      709          410         |729 (T)      688          716          555          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.543      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.158      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.489      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.214      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.484      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.225      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.498      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.200      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.505      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.177      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.243      P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      1/46.10      1/45.28      0/30.48     |2/46.90      1/44.06      0/46.06      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.2%         0.0%        |4.3%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    1/39 (3%)    0/14 (0%)   |2/39 (5%)    1/32 (3%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          714          730 (T)      ---         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.690      P=0.510      P=0.505      (e)         |P=0.136N     P=0.569N     P=0.238N     P=0.361N     | 
|POLY 3             |     P=0.659      P=0.500      P=0.496      (e)         |P=0.107N     P=0.522N     P=0.241N     P=0.306N     | 
|POLY 1.5           |     P=0.618N     P=0.496      P=0.496      (e)         |P=0.105N     P=0.513N     P=0.242N     P=0.285N     | 
|POLY 6             |     P=0.630      P=0.504      P=0.497      (e)         |P=0.109N     P=0.533N     P=0.239N     P=0.327N     | 
|LOGISTIC REGRESSION|     P=0.674N     P=0.498      P=0.505      (e)         |P=0.136N     P=0.569N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.545N     P=0.500      P=0.500      (e)         |P=0.104N     P=0.500N     P=0.253N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      2/46.74      1/45.28      0/30.48     |2/46.90      1/44.06      0/46.06      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         2.2%         0.0%        |4.3%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    1/39 (3%)    0/14 (0%)   |2/39 (5%)    1/32 (3%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          518          730 (T)      ---         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.524N     P=0.243      P=0.505      (e)         |P=0.136N     P=0.569N     P=0.238N     P=0.361N     | 
|POLY 3             |     P=0.510N     P=0.240      P=0.496      (e)         |P=0.107N     P=0.522N     P=0.241N     P=0.306N     | 
|POLY 1.5           |     P=0.453N     P=0.235      P=0.496      (e)         |P=0.105N     P=0.513N     P=0.242N     P=0.285N     | 
|POLY 6             |     P=0.568N     P=0.246      P=0.497      (e)         |P=0.109N     P=0.533N     P=0.239N     P=0.327N     | 
|LOGISTIC REGRESSION|     P=0.345N     P=0.269      P=0.505      (e)         |P=0.136N     P=0.569N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.372N     P=0.247      P=0.500      (e)         |P=0.104N     P=0.500N     P=0.253N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.90      1/44.60      0/47.00      2/35.49      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.2%         0.0%         5.6%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/32 (0%)    0/39 (0%)    1/23 (4%)    | 
|FIRST INCIDENCE    |                                                        |---          563          ---          649          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.104      P=0.496      (e)          P=0.147      | 
|POLY 3             |                                                        |P=0.140      P=0.490      (e)          P=0.182      | 
|POLY 1.5           |                                                        |P=0.141      P=0.494      (e)          P=0.196      | 
|POLY 6             |                                                        |P=0.144      P=0.485      (e)          P=0.170      | 
|LOGISTIC REGRESSION|                                                        |P=0.187      P=0.551      (e)          P=0.191      | 
|COCH-ARM / FISHERS |                                                        |P=0.163      P=0.500      (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.90      1/44.08      3/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.3%         6.4%         0.0%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/32 (0%)    3/39 (8%)    0/23 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          724          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.512      P=0.467      P=0.121      (e)          | 
|POLY 3             |                                                        |P=0.441      P=0.488      P=0.119      (e)          | 
|POLY 1.5           |                                                        |P=0.491      P=0.493      P=0.119      (e)          | 
|POLY 6             |                                                        |P=0.400      P=0.481      P=0.120      (e)          | 
|LOGISTIC REGRESSION|                                                        |P=0.524      P=0.473      P=0.121      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.627      P=0.500      P=0.121      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/46.22      2/46.03      1/45.28      2/30.51     |0/46.90      1/44.60      1/47.00      4/35.85      | 
|POLY-3 PERCENT (g) |     4.3%         4.3%         2.2%         6.6%        |0.0%         2.2%         2.1%         11.2%        | 
|TERMINAL (d)       |     1/38 (3%)    2/42 (5%)    1/39 (3%)    1/14 (7%)   |0/39 (0%)    0/32 (0%)    1/39 (3%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     723          730 (T)      730 (T)      724         |---          563          729 (T)      649          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.301      P=0.662N     P=0.497N     P=0.347     |P=0.006 **   P=0.496      P=0.500      P=0.024 *    | 
|POLY 3             |     P=0.529      P=0.692      P=0.507N     P=0.536     |P=0.012 *    P=0.490      P=0.500      P=0.034 *    | 
|POLY 1.5           |     P=0.547      P=0.687      P=0.506N     P=0.588     |P=0.013 *    P=0.494      P=0.500      P=0.040 *    | 
|POLY 6             |     P=0.520      P=0.688N     P=0.506N     P=0.482     |P=0.012 *    P=0.485      P=0.502      P=0.029 *    | 
|LOGISTIC REGRESSION|     P=0.362      P=0.679N     P=0.503N     P=0.412     |P=0.017 *    P=0.551      P=0.500      P=0.039 *    | 
|COCH-ARM / FISHERS |     P=0.561N     P=0.691N     P=0.500N     P=0.691N    |P=0.019 *    P=0.500      P=0.500      P=0.059      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    4/50 (8%)    3/50 (6%)   |4/50 (8%)    3/50 (6%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/46.69      1/46.03      4/45.28      3/30.48     |4/46.90      3/44.06      2/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     6.4%         2.2%         8.8%         9.8%        |8.5%         6.8%         4.3%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    1/42 (2%)    4/39 (10%)   3/14 (21%)  |4/39 (10%)   3/32 (9%)    2/39 (5%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     582          730 (T)      730 (T)      730 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.055      P=0.284N     P=0.507      P=0.228     |P=0.072N     P=0.608N     P=0.336N     P=0.148N     | 
|POLY 3             |     P=0.193      P=0.310N     P=0.483      P=0.457     |P=0.062N     P=0.534N     P=0.336N     P=0.107N     | 
|POLY 1.5           |     P=0.237      P=0.315N     P=0.487      P=0.524     |P=0.054N     P=0.520N     P=0.339N     P=0.091N     | 
|POLY 6             |     P=0.159      P=0.305N     P=0.482      P=0.389     |P=0.070N     P=0.552N     P=0.333N     P=0.124N     | 
|LOGISTIC REGRESSION|     P=0.153      P=0.301N     P=0.494      P=0.431     |P=0.072N     P=0.608N     P=0.336N     (e)          | 
|COCH-ARM / FISHERS |     P=0.373      P=0.309N     P=0.500      P=0.661N    |P=0.037N*    P=0.500N     P=0.339N     P=0.059N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    5/50 (10%)   5/50 (10%)  |4/50 (8%)    4/50 (8%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     5/46.72      3/46.03      5/45.28      5/30.51     |4/46.90      4/44.60      3/47.00      4/35.85      | 
|POLY-3 PERCENT (g) |     10.7%        6.5%         11.0%        16.4%       |8.5%         9.0%         6.4%         11.2%        | 
|TERMINAL (d)       |     3/38 (8%)    3/42 (7%)    5/39 (13%)   4/14 (29%)  |4/39 (10%)   3/32 (9%)    3/39 (8%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     582          730 (T)      730 (T)      724         |729 (T)      563          729 (T)      649          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.036 *    P=0.318N     P=0.621N     P=0.114     |P=0.369      P=0.544      P=0.500N     P=0.369      | 
|POLY 3             |     P=0.211      P=0.365N     P=0.610      P=0.358     |P=0.470      P=0.615      P=0.499N     P=0.490      | 
|POLY 1.5           |     P=0.262      P=0.371N     P=0.615      P=0.444     |P=0.496      P=0.627      P=0.501N     P=0.533      | 
|POLY 6             |     P=0.174      P=0.356N     P=0.608      P=0.276     |P=0.457      P=0.601      P=0.495N     P=0.454      | 
|LOGISTIC REGRESSION|     P=0.113      P=0.363N     P=0.620      P=0.268     |P=0.474      P=0.627      P=0.500N     P=0.481      | 
|COCH-ARM / FISHERS |     P=0.421      P=0.357N     P=0.630N     P=0.630N    |P=0.543N     P=0.643N     P=0.500N     P=0.643N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |4/50 (8%)    5/50 (10%)   7/50 (14%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     3/46.22      3/46.03      1/45.28      3/31.35     |4/46.90      5/45.49      7/47.99      6/36.54      | 
|POLY-3 PERCENT (g) |     6.5%         6.5%         2.2%         9.6%        |8.5%         11.0%        14.6%        16.4%        | 
|TERMINAL (d)       |     2/38 (5%)    3/42 (7%)    1/39 (3%)    1/14 (7%)   |4/39 (10%)   3/32 (9%)    6/39 (15%)   3/23 (13%)   | 
|FIRST INCIDENCE    |     723          730 (T)      730 (T)      502         |729 (T)      354          190          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.280      P=0.619N     P=0.302N     P=0.291     |P=0.106      P=0.405      P=0.262      P=0.134      | 
|POLY 3             |     P=0.539      P=0.660      P=0.313N     P=0.475     |P=0.156      P=0.481      P=0.275      P=0.227      | 
|POLY 1.5           |     P=0.558      P=0.653      P=0.312N     P=0.534     |P=0.183      P=0.490      P=0.271      P=0.262      | 
|POLY 6             |     P=0.531      P=0.655N     P=0.312N     P=0.417     |P=0.139      P=0.467      P=0.279      P=0.199      | 
|LOGISTIC REGRESSION|     P=0.509      P=0.640N     P=0.306N     P=0.530     |P=0.373      P=0.559      P=0.273      P=0.276      | 
|COCH-ARM / FISHERS |     P=0.521N     P=0.661N     P=0.309N     P=0.661N    |P=0.293      P=0.500      P=0.262      P=0.370      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 21      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      2/46.74      0/45.28      1/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         3.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    1/14 (7%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          518          ---          730 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476      P=0.243      (e)          P=0.301     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.570      P=0.240      (e)          P=0.420     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.568      P=0.235      (e)          P=0.445     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.582      P=0.246      (e)          P=0.395     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.653N     P=0.269      (e)          P=0.301     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.628      P=0.247      (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      2/46.74      0/45.28      1/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         3.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    1/14 (7%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          518          ---          730 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476      P=0.243      (e)          P=0.301     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.570      P=0.240      (e)          P=0.420     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.568      P=0.235      (e)          P=0.445     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.582      P=0.246      (e)          P=0.395     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.653N     P=0.269      (e)          P=0.301     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.628      P=0.247      (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 22      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  39/50 (78%)  45/50 (90%)  39/50 (78%) |29/50 (58%)  33/50 (66%)  45/50 (90%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     34/48.44     39/47.06     45/49.02     39/40.86    |29/48.17     33/45.94     45/47.93     33/39.44     | 
|POLY-3 PERCENT (g) |     70.2%        82.9%        91.8%        95.4%       |60.2%        71.8%        93.9%        83.7%        | 
|TERMINAL (d)       |     27/38 (71%)  35/42 (83%)  35/39 (90%)  14/14 (100%)|26/39 (67%)  25/32 (78%)  38/39 (97%)  20/23 (87%)  | 
|FIRST INCIDENCE    |     464          518          497          410         |338          563          639          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.440      P=0.041 *    P<0.001 **  |P<0.001 **   P=0.043 *    P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.106      P=0.005 **   P<0.001 **  |P<0.001 **   P=0.159      P<0.001 **   P=0.011 *    | 
|POLY 1.5           |     P=0.002 **   P=0.103      P=0.004 **   P=0.005 **  |P=0.003 **   P=0.193      P<0.001 **   P=0.030 *    | 
|POLY 6             |     P<0.001 **   P=0.113      P=0.007 **   P<0.001 **  |P<0.001 **   P=0.131      P<0.001 **   P=0.006 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.134      P=0.005 **   P<0.001 **  |P<0.001 **   P=0.168      P<0.001 **   P=0.010 *    | 
|COCH-ARM / FISHERS |     P=0.150      P=0.184      P=0.006 **   P=0.184     |P=0.161      P=0.268      P<0.001 **   P=0.268      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  18/50 (36%)  30/50 (60%)  24/50 (48%) |24/50 (48%)  22/50 (44%)  30/50 (60%)  24/50 (48%)  | 
|POLY-3 RATE (b)    |     29/49.58     18/48.00     30/48.37     24/36.08    |24/48.92     22/46.98     30/49.92     24/39.58     | 
|POLY-3 PERCENT (g) |     58.5%        37.5%        62.0%        66.5%       |49.1%        46.8%        60.1%        60.6%        | 
|TERMINAL (d)       |     18/38 (47%)  12/42 (29%)  21/39 (54%)  6/14 (43%)  |16/39 (41%)  12/32 (38%)  21/39 (54%)  10/23 (44%)  | 
|FIRST INCIDENCE    |     464          518          497          494         |562          354          190          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.026N*    P=0.515      P=0.014 *   |P=0.026 *    P=0.443      P=0.212      P=0.047 *    | 
|POLY 3             |     P=0.048 *    P=0.029N*    P=0.441      P=0.299     |P=0.080      P=0.494N     P=0.185      P=0.192      | 
|POLY 1.5           |     P=0.112      P=0.030N*    P=0.451      P=0.487     |P=0.118      P=0.460N     P=0.177      P=0.272      | 
|POLY 6             |     P=0.023 *    P=0.027N*    P=0.440      P=0.177     |P=0.065      P=0.542N     P=0.189      P=0.147      | 
|LOGISTIC REGRESSION|     P=0.193      P=0.021N*    P=0.521      P=0.475     |P=0.218      P=0.397N     P=0.155      P=0.262      | 
|COCH-ARM / FISHERS |     P=0.505      P=0.022N*    P=0.500      P=0.212N    |P=0.375      P=0.421N     P=0.158      P=0.579N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 23      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   ACRYLONITRILE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  43/50 (86%)  49/50 (98%)  41/50 (82%) |39/50 (78%)  41/50 (82%)  50/50 (100%) 40/50 (80%)  | 
|POLY-3 RATE (b)    |     45/50.00     43/48.00     49/49.02     41/41.72    |39/49.82     41/47.64     50/50.00     40/40.97     | 
|POLY-3 PERCENT (g) |     90.0%        89.6%        100.0%       98.3%       |78.3%        86.1%        100.0%       97.6%        | 
|TERMINAL (d)       |     33/38 (87%)  37/42 (88%)  39/39 (100%) 14/14 (100%)|30/39 (77%)  28/32 (88%)  39/39 (100%) 23/23 (100%) | 
|FIRST INCIDENCE    |     464          518          497          410         |338          354          190          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.183N     P=0.323      P<0.001 **  |P<0.001 **   P=0.082      P=0.032 *    P<0.001 **   | 
|POLY 3             |     P=0.014 *    P=0.604N     P=0.034 *    P=0.106     |P<0.001 **   P=0.226      P<0.001 **   P=0.005 **   | 
|POLY 1.5           |     P=0.063      P=0.604N     P=0.039 *    P=0.260     |P=0.002 **   P=0.288      P<0.001 **   P=0.026 *    | 
|POLY 6             |     P=0.007 **   P=0.604N     P=0.033 *    P=0.065     |P<0.001 **   P=0.168      P<0.001 **   P=0.002 **   | 
|LOGISTIC REGRESSION|     P=0.024 *    P=0.504N     P=0.066      P=0.083     |P=0.005 **   P=0.359      P<0.001 **   P=0.013 *    | 
|COCH-ARM / FISHERS |     P=0.245N     P=0.380N     P=0.102      P=0.194N    |P=0.340      P=0.402      P<0.001 **   P=0.500      | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).