Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/5000

TDMS Study 50215-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                       ACRYLONITRILE                                     DATE: 10/31/00       
EXPERIMENT: 50215 TEST: 03                                                                                     TIME: 12:46:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55388                              ROUTE: GAVAGE                                                  NTP C#: 50215B       
PATHOLOGIST: MISSING                                                                                           CAS: 107-13-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            MICE FINAL#1                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                       ACRYLONITRILE                                     DATE: 10/31/00       
EXPERIMENT: 50215 TEST: 03                                                                                     TIME: 12:46:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: GAVAGE                                                  NTP C#: 50215B       
PATHOLOGIST: MISSING                                                                                           CAS: 107-13-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  ACRYLONITRILE                                                                                   
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hypertrophy                                                                                  
Adrenal Cortex: Subcapsular            Hyperplasia                                                                                  
Bone Marrow: Myeloid Cell              Hyperplasia                                                                                  
Epididymis                             Infiltration Cellular Mononuclear Cell                                                       
Eye                                    Synechia                                                                                     
Eye: Cornea                            Inflammation Chronic                                                                         
Harderian Gland                        Hyperplasia                                                                                  
                                       Infiltration Cellular Mononuclear Cell                                                       
Kidney                                 Mineralization                                                                               
                                       Nephropathy                                                                                  
Kidney: Cortex                         Cyst                                                                                         
Kidney: Renal Tubule                   Hyperplasia                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Inflammation Chronic                                                                         
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mandibular                 Hyperplasia Lymphoid                                                                         
Lymph Node, Mesenteric                 Ectasia                                                                                      
                                       Hyperplasia Lymphoid                                                                         
Mesentery: Fat                         Necrosis                                                                                     
Nose: Nasolacrimal Duct                Inflammation                                                                                 
Preputial Gland                        Infiltration Cellular Mononuclear Cell                                                       
                                       Inflammation Chronic                                                                         
Preputial Gland: Duct                  Ectasia                                                                                      
Prostate                               Infiltration Cellular Mononuclear Cell                                                       
Salivary Glands                        Infiltration Cellular Mononuclear Cell                                                       
Spleen                                 Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Hyperkeratosis Diffuse                                                                       
                                       Hyperkeratosis Focal                                                                         
Stomach, Forestomach: Epithelium       Hyperplasia Focal                                                                            
Stomach, Glandular: Glands             Ectasia                                                                                      
Thymus: Thymocyte                      Necrosis                                                                                     
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex: Subcapsular            Hyperplasia                                                                                  
Bone Marrow: Myeloid Cell              Hyperplasia                                                                                  
Harderian Gland                        Hyperplasia                                                                                  
                                       Infiltration Cellular Mononuclear Cell                                                       
Heart                                  Inflammation Chronic                                                                         
Kidney                                 Nephropathy                                                                                  
Liver                                  Angiectasis                                                                                  
                                       Basophilic Focus                                                                             
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                       ACRYLONITRILE                                     DATE: 10/31/00       
EXPERIMENT: 50215 TEST: 03                                                                                     TIME: 12:46:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: GAVAGE                                                  NTP C#: 50215B       
PATHOLOGIST: MISSING                                                                                           CAS: 107-13-1        
                                       Eosinophilic Focus                                                                           
                                       Inflammation Chronic                                                                         
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
                                       Pigmentation                                                                                 
                                       Vacuolization Cytoplasmic                                                                    
Lymph Node, Mandibular                 Hyperplasia Lymphoid                                                                         
Ovary                                  Atrophy                                                                                      
                                       Cyst                                                                                         
                                       Mineralization                                                                               
                                       Thrombosis                                                                                   
Pancreas                               Infiltration Cellular Mononuclear Cell                                                       
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Salivary Glands                        Infiltration Cellular Mononuclear Cell                                                       
Spleen                                 Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Hyperkeratosis Diffuse                                                                       
Stomach, Forestomach: Epithelium       Hyperplasia Focal                                                                            
Thyroid Gland: Follicle                Cyst                                                                                         
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                   ACRYLONITRILE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      0/46.03      0/45.28      0/30.48     |1/47.44      2/44.19      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.1%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    1/32 (3%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |562          696          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.181N     P=0.449      P=0.504N     P=0.561N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.159N     P=0.475      P=0.502N     P=0.558N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.151N     P=0.485      P=0.502N     P=0.541N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.169N     P=0.463      P=0.501N     P=0.574N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.115N     P=0.537      P=0.445N     P=0.400N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.141N     P=0.500      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  21/50 (42%)  19/50 (38%)  2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     19/46.19     21/46.68     19/45.28     2/30.48     |0/46.90      0/44.06      0/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |     41.1%        45.0%        42.0%        6.6%        |0.0%         0.0%         0.0%         2.8%         | 
|TERMINAL (d)       |     19/38 (50%)  20/42 (48%)  19/39 (49%)  2/14 (14%)  |0/39 (0%)    0/32 (0%)    0/39 (0%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     730 (T)      518          730 (T)      730 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.030N*    P=0.581      P=0.546N     P=0.023N*   |P=0.131      (e)          (e)          P=0.395      | 
|POLY 3             |     P=0.004N**   P=0.434      P=0.552      P<0.001N**  |P=0.168      (e)          (e)          P=0.444      | 
|POLY 1.5           |     P<0.001N**   P=0.400      P=0.555      P<0.001N**  |P=0.165      (e)          (e)          P=0.460      | 
|POLY 6             |     P=0.017N*    P=0.478      P=0.559      P=0.003N**  |P=0.179      (e)          (e)          P=0.429      | 
|LOGISTIC REGRESSION|     P=0.006N**   P=0.449      P=0.546N     P=0.023N*   |(e)          (e)          (e)          P=0.395      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.419      P=0.582N     P<0.001N**  |P=0.188      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Subcapsular                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  43/50 (86%)  40/50 (80%)  36/50 (72%) |50/50 (100%) 49/50 (98%)  47/50 (94%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     45/50.00     43/46.96     40/47.30     36/40.97    |50/50.00     49/49.79     47/49.30     49/49.02     | 
|POLY-3 PERCENT (g) |     90.0%        91.6%        84.6%        87.9%       |100.0%       98.4%        95.3%        100.0%       | 
|TERMINAL (d)       |     33/38 (87%)  40/42 (95%)  34/39 (87%)  12/14 (86%) |39/39 (100%) 32/32 (100%) 38/39 (97%)  23/23 (100%) | 
|FIRST INCIDENCE    |     464          535          497          239         |338          354          190          113          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.151N     P=0.186N     P<0.001 **  |P<0.001 **   P=0.108      P=0.315N     P<0.001 **   | 
|POLY 3             |     P=0.291N     P=0.534      P=0.304N     P=0.505N    |P=0.642N     P=0.606N     P=0.174N     P=1.000N     | 
|POLY 1.5           |     P=0.135N     P=0.587      P=0.235N     P=0.276N    |P=0.596N     P=0.550N     P=0.145N     P=1.000N     | 
|POLY 6             |     P=0.460N     P=0.464      P=0.389N     P=0.587     |P=0.650N     P=0.729N     P=0.218N     P=1.000N     | 
|LOGISTIC REGRESSION|     P=0.412N     P=0.529N     P=0.168N     P=0.376N    |P=0.607N     P=0.516N     P=0.129N     P=0.996N     | 
|COCH-ARM / FISHERS |     P=0.009N**   P=0.380N     P=0.131N     P=0.020N*   |P=0.345N     P=0.500N     P=0.121N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      0/46.03      2/45.28      0/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    2/39 (5%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          730 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.353      (e)          P=0.244      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.325      (e)          P=0.233      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.381      (e)          P=0.233      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.270      (e)          P=0.233      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.244      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.545      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Myeloid Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    4/50 (8%)    2/50 (4%)   |1/50 (2%)    5/50 (10%)   3/50 (6%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/46.19      1/46.03      4/45.93      2/31.43     |1/47.44      5/44.80      3/47.31      5/36.96      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         8.7%         6.4%        |2.1%         11.2%        6.3%         13.5%        | 
|TERMINAL (d)       |     0/38 (0%)    1/42 (2%)    1/39 (3%)    0/14 (0%)   |0/39 (0%)    1/32 (3%)    2/39 (5%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      626          502         |562          633          646          386          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035 *    P=0.520      P=0.068      P=0.153     |P=0.087      P=0.083      P=0.304      P=0.048 *    | 
|POLY 3             |     P=0.052      P=0.499      P=0.060      P=0.164     |P=0.119      P=0.089      P=0.304      P=0.055      | 
|POLY 1.5           |     P=0.072      P=0.496      P=0.059      P=0.184     |P=0.135      P=0.094      P=0.304      P=0.066      | 
|POLY 6             |     P=0.038 *    P=0.504      P=0.061      P=0.147     |P=0.109      P=0.083      P=0.307      P=0.048 *    | 
|LOGISTIC REGRESSION|     P=0.146      P=0.520      P=0.066      P=0.285     |P=0.262      P=0.122      P=0.320      P=0.149      | 
|COCH-ARM / FISHERS |     P=0.154      P=0.500      P=0.059      P=0.247     |P=0.199      P=0.102      P=0.309      P=0.102      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      2/46.80      0/45.28      0/30.48     |0/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          535          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.362N     P=0.245      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.338N     P=0.240      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.309N     P=0.235      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.368N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.226N     P=0.271      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.284N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    0/48 (0%)    0/49 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/46.98      0/42.38      0/46.06      0/34.05      | 
|POLY-3 PERCENT (g) |                                                        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |1/39 (3%)    0/32 (0%)    0/39 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |                                                        |708          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.185N     P=0.283N     P=0.232N     P=0.363N     | 
|POLY 3             |                                                        |P=0.139N     P=0.261N     P=0.242N     P=0.315N     | 
|POLY 1.5           |                                                        |P=0.142N     P=0.255N     P=0.243N     P=0.294N     | 
|POLY 6             |                                                        |P=0.139N     P=0.268N     P=0.240N     P=0.336N     | 
|LOGISTIC REGRESSION|                                                        |P=0.178N     P=0.264N     P=0.242N     P=0.330N     | 
|COCH-ARM / FISHERS |                                                        |P=0.155N     P=0.258N     P=0.253N     P=0.258N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    1/48 (2%)    0/49 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |                                                        |3/46.90      1/42.38      0/46.06      1/34.05      | 
|POLY-3 PERCENT (g) |                                                        |6.4%         2.4%         0.0%         2.9%         | 
|TERMINAL (d)       |                                                        |3/39 (8%)    1/32 (3%)    0/39 (0%)    1/22 (5%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.328N     P=0.378N     P=0.121N     P=0.524N     | 
|POLY 3             |                                                        |P=0.228N     P=0.342N     P=0.122N     P=0.427N     | 
|POLY 1.5           |                                                        |P=0.229N     P=0.333N     P=0.123N     P=0.395N     | 
|POLY 6             |                                                        |P=0.227N     P=0.353N     P=0.120N     P=0.458N     | 
|LOGISTIC REGRESSION|                                                        |P=0.328N     P=0.378N     (e)          P=0.524N     | 
|COCH-ARM / FISHERS |                                                        |P=0.228N     P=0.324N     P=0.125N     P=0.324N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  31/50 (62%)  38/50 (76%)  16/50 (32%) |                                                    | 
|POLY-3 RATE (b)    |     41/48.70     31/46.80     38/48.16     16/33.51    |                                                    | 
|POLY-3 PERCENT (g) |     84.2%        66.2%        78.9%        47.8%       |                                                    | 
|TERMINAL (d)       |     32/38 (84%)  29/42 (69%)  32/39 (82%)  8/14 (57%)  |                                                    | 
|FIRST INCIDENCE    |     528          535          211          239         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.361      P=0.008N**   P=0.303N     P=0.453N    |                                                    | 
|POLY 3             |     P=0.006N**   P=0.032N*    P=0.337N     P<0.001N**  |                                                    | 
|POLY 1.5           |     P<0.001N**   P=0.034N*    P=0.323N     P<0.001N**  |                                                    | 
|POLY 6             |     P=0.043N*    P=0.032N*    P=0.366N     P=0.003N**  |                                                    | 
|LOGISTIC REGRESSION|     P=0.002N**   P=0.027N*    P=0.346N     P<0.001N**  |                                                    | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.022N*    P=0.312N     P<0.001N**  |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.19      0/46.03      1/45.39      0/30.48     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         2.2%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/38 (5%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |                                                    | 
|FIRST INCIDENCE    |     730 (T)      ---          702          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.395N     P=0.217N     P=0.494N     P=0.475N    |                                                    | 
|POLY 3             |     P=0.324N     P=0.238N     P=0.506N     P=0.340N    |                                                    | 
|POLY 1.5           |     P=0.283N     P=0.242N     P=0.506N     P=0.305N    |                                                    | 
|POLY 6             |     P=0.369N     P=0.233N     P=0.504N     P=0.377N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.337N     (e)          P=0.506N     (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.242N     P=0.247N     P=0.500N     P=0.247N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus                                                                                                                        | 
|     Perforation                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.19      2/48.03      0/45.28      0/30.48     |0/46.90      0/44.06      0/46.06      1/36.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.8%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          3            ---          ---         |---          ---          ---          113          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.284N     P=0.238      (e)          (e)         |P=0.188      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.338N     P=0.246      (e)          (e)         |P=0.165      (e)          (e)          P=0.449      | 
|POLY 1.5           |     P=0.308N     P=0.242      (e)          (e)         |P=0.168      (e)          (e)          P=0.464      | 
|POLY 6             |     P=0.368N     P=0.251      (e)          (e)         |P=0.174      (e)          (e)          P=0.435      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.284N     P=0.247      (e)          (e)         |P=0.188      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     1/1 (100%)   4/6 (67%)    2/3 (67%)   |0/0 (0%)     1/1 (100%)   1/2 (50%)    7/9 (78%)    | 
|POLY-3 RATE (b)    |     0/0.00       1/1.00       4/6.00       2/3.00      |0/0.00       1/1.00       1/2.00       7/9.00       | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       66.7%        66.7%       |0.0%         100.0%       50.0%        77.8%        | 
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   2/4 (50%)    0/1 (0%)    |0/0 (0%)     1/1 (100%)   0/1 (0%)     6/8 (75%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      497          554         |---          729 (T)      639          352          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.094      (e)          P=0.237      P=0.102     |P=0.180      (e)          P=0.505      P=0.441      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.586N     (e)          P=1.000      P=1.000     |P=0.696      (e)          P=1.000      P=1.000      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Synechia                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/1 (0%)     2/6 (33%)    2/3 (67%)   |0/0 (0%)     0/1 (0%)     1/2 (50%)    1/9 (11%)    | 
|POLY-3 RATE (b)    |     0/0.00       0/1.00       2/5.46       2/3.00      |0/0.00       0/1.00       1/2.00       1/8.11       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         36.6%        66.7%       |0.0%         0.0%         50.0%        12.3%        | 
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     1/4 (25%)    0/1 (0%)    |0/0 (0%)     0/1 (0%)     0/1 (0%)     1/8 (13%)    | 
|FIRST INCIDENCE    |     ---          ---          497          554         |---          ---          639          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    (e)          P=0.496      P=0.102     |P=0.468      (e)          P=0.505      P=1.000      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.277      (e)          (e)          (e)         |P=0.565N     (e)          (e)          P=1.000      | 
|COCH-ARM / FISHERS |     P=0.242      (e)          P=1.000      P=1.000     |P=0.568N     (e)          P=1.000      P=1.000      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/1 (0%)     3/6 (50%)    3/3 (100%)  |0/0 (0%)     1/1 (100%)   0/2 (0%)     5/9 (56%)    | 
|POLY-3 RATE (b)    |     0/0.00       0/1.00       3/5.32       3/3.00      |0/0.00       1/1.00       0/1.67       5/8.11       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         56.4%        100.0%      |0.0%         100.0%       0.0%         61.6%        | 
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     2/4 (50%)    1/1 (100%)  |0/0 (0%)     1/1 (100%)   0/1 (0%)     5/8 (63%)    | 
|FIRST INCIDENCE    |     ---          ---          563          554         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005 **   (e)          P=0.500      (e)         |P=0.665N     (e)          (e)          P=1.000N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.089      (e)          (e)          (e)         |(e)          (e)          (e)          P=1.000N     | 
|COCH-ARM / FISHERS |     P=0.090      (e)          P=1.000      (e)         |P=0.648      (e)          (e)          P=1.000      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     1/1 (100%)   3/6 (50%)    2/3 (67%)   |0/0 (0%)     0/1 (0%)     0/2 (0%)     2/9 (22%)    | 
|POLY-3 RATE (b)    |     0/0.00       1/1.00       3/5.46       2/3.00      |0/0.00       0/1.00       0/1.67       2/9.00       | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       55.0%        66.7%       |0.0%         0.0%         0.0%         22.2%        | 
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   2/4 (50%)    0/1 (0%)    |0/0 (0%)     0/1 (0%)     0/1 (0%)     1/8 (13%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      497          554         |---          ---          ---          352          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.116      (e)          P=0.496      P=0.102     |P=0.134      (e)          (e)          P=0.441      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.659N     (e)          (e)          (e)         |P=0.526      (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.680N     (e)          P=1.000      P=1.000     |P=0.432      (e)          (e)          P=1.000      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    7/50 (14%)   4/50 (8%)   |5/49 (10%)   4/50 (8%)    6/49 (12%)   8/49 (16%)   | 
|POLY-3 RATE (b)    |     1/46.27      4/46.03      7/45.69      4/31.14     |5/46.16      4/44.06      6/46.06      8/36.72      | 
|POLY-3 PERCENT (g) |     2.2%         8.7%         15.3%        12.8%       |10.8%        9.1%         13.0%        21.8%        | 
|TERMINAL (d)       |     0/38 (0%)    4/42 (10%)   6/39 (15%)   2/14 (14%)  |5/39 (13%)   4/32 (13%)   6/39 (15%)   5/23 (22%)   | 
|FIRST INCIDENCE    |     712          730 (T)      610          547         |729 (T)      729 (T)      729 (T)      386          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.009 **   P=0.208      P=0.036 *    P=0.031 *   |P=0.026 *    P=0.624N     P=0.500      P=0.066      | 
|POLY 3             |     P=0.050      P=0.177      P=0.029 *    P=0.086     |P=0.072      P=0.529N     P=0.499      P=0.147      | 
|POLY 1.5           |     P=0.078      P=0.173      P=0.029 *    P=0.109     |P=0.083      P=0.512N     P=0.497      P=0.177      | 
|POLY 6             |     P=0.032 *    P=0.183      P=0.029 *    P=0.067     |P=0.065      P=0.552N     P=0.502      P=0.123      | 
|LOGISTIC REGRESSION|     P=0.059      P=0.188      P=0.031 *    P=0.085     |P=0.068      P=0.624N     P=0.500      P=0.194      | 
|COCH-ARM / FISHERS |     P=0.201      P=0.181      P=0.030 *    P=0.181     |P=0.134      P=0.487N     P=0.500      P=0.276      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  25/50 (50%)  26/50 (52%)  14/50 (28%) |40/49 (82%)  30/50 (60%)  33/49 (67%)  23/49 (47%)  | 
|POLY-3 RATE (b)    |     33/47.49     25/47.17     26/45.79     14/34.09    |40/47.06     30/47.68     33/46.89     23/39.05     | 
|POLY-3 PERCENT (g) |     69.5%        53.0%        56.8%        41.1%       |85.0%        62.9%        70.4%        58.9%        | 
|TERMINAL (d)       |     29/38 (76%)  22/42 (52%)  23/39 (59%)  7/14 (50%)  |35/39 (90%)  20/32 (63%)  28/39 (72%)  12/23 (52%)  | 
|FIRST INCIDENCE    |     528          518          626          283         |653          354          645          352          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407      P=0.029N*    P=0.090N     P=0.566     |P=0.365N     P=0.299N     P=0.099N     P=0.429N     | 
|POLY 3             |     P=0.024N*    P=0.072N     P=0.139N     P=0.007N**  |P=0.031N*    P=0.010N*    P=0.067N     P=0.004N**   | 
|POLY 1.5           |     P=0.006N**   P=0.088N     P=0.133N     P=0.002N**  |P=0.019N*    P=0.011N*    P=0.074N     P=0.002N**   | 
|POLY 6             |     P=0.067N     P=0.054N     P=0.139N     P=0.025N*   |P=0.042N*    P=0.010N*    P=0.059N     P=0.007N**   | 
|LOGISTIC REGRESSION|     P=0.027N*    P=0.086N     P=0.123N     P=0.013N*   |P=0.038N*    P=0.025N*    P=0.069N     P=0.015N*    | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.078N     P=0.111N     P<0.001N**  |P=0.002N**   P=0.016N*    P=0.082N     P<0.001N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/46.19      3/46.35      2/45.28      1/30.48     |0/46.90      1/44.24      1/47.00      3/35.49      | 
|POLY-3 PERCENT (g) |     2.2%         6.5%         4.4%         3.3%        |0.0%         2.3%         2.1%         8.5%         | 
|TERMINAL (d)       |     1/38 (3%)    1/42 (2%)    2/39 (5%)    1/14 (7%)   |0/39 (0%)    0/32 (0%)    1/39 (3%)    2/23 (9%)    | 
|FIRST INCIDENCE    |     730 (T)      689          730 (T)      730 (T)     |---          683          729 (T)      649          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.484      P=0.338      P=0.509      P=0.525     |P=0.022 *    P=0.475      P=0.500      P=0.053      | 
|POLY 3             |     P=0.586N     P=0.307      P=0.493      P=0.659     |P=0.040 *    P=0.488      P=0.500      P=0.077      | 
|POLY 1.5           |     P=0.526N     P=0.300      P=0.494      P=0.694     |P=0.043 *    P=0.493      P=0.500      P=0.087      | 
|POLY 6             |     P=0.559      P=0.316      P=0.494      P=0.622     |P=0.039 *    P=0.483      P=0.502      P=0.069      | 
|LOGISTIC REGRESSION|     P=0.604      P=0.301      P=0.509      P=0.525     |P=0.035 *    P=0.511      P=0.500      P=0.074      | 
|COCH-ARM / FISHERS |     P=0.414N     P=0.309      P=0.500      P=0.753N    |P=0.059      P=0.500      P=0.500      P=0.121      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.53      0/46.03      0/45.28      1/30.96     |1/47.23      1/44.24      0/47.00      1/36.08      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         3.2%        |2.1%         2.3%         0.0%         2.8%         | 
|TERMINAL (d)       |     1/38 (3%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     636          ---          ---          588         |638          683          ---          352          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.638      P=0.224N     P=0.239N     P=0.729     |P=0.645      P=0.739      P=0.500N     P=0.715      | 
|POLY 3             |     P=0.521N     P=0.240N     P=0.243N     P=0.635N    |P=0.591N     P=0.746      P=0.501N     P=0.697      | 
|POLY 1.5           |     P=0.510N     P=0.243N     P=0.242N     P=0.594N    |P=0.592N     P=0.752      P=0.501N     P=0.716      | 
|POLY 6             |     P=0.526N     P=0.236N     P=0.244N     P=0.674N    |P=0.595N     P=0.738      P=0.500N     P=0.677      | 
|LOGISTIC REGRESSION|     P=0.495N     P=0.230N     P=0.226N     P=0.529N    |P=0.375N     P=0.741N     P=0.479N     P=0.602N     | 
|COCH-ARM / FISHERS |     P=0.519N     P=0.247N     P=0.247N     P=0.500N    |P=0.592N     P=0.753N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum: Peyer's Patch                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.19      1/46.03      0/45.28      0/30.48     |0/46.90      1/44.06      1/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         0.0%         0.0%        |0.0%         2.3%         2.1%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    1/32 (3%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.178N     P=0.465N     P=0.233N     P=0.475N    |P=0.636N     P=0.461      P=0.500      (e)          | 
|POLY 3             |     P=0.122N     P=0.501N     P=0.242N     P=0.340N    |P=0.617N     P=0.488      P=0.500      (e)          | 
|POLY 1.5           |     P=0.110N     P=0.507N     P=0.241N     P=0.305N    |P=0.590N     P=0.493      P=0.500      (e)          | 
|POLY 6             |     P=0.134N     P=0.494N     P=0.241N     P=0.377N    |P=0.648N     P=0.481      P=0.502      (e)          | 
|LOGISTIC REGRESSION|     P=0.178N     P=0.465N     (e)          (e)         |(e)          P=0.461      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.104N     P=0.500N     P=0.247N     P=0.247N    |P=0.545N     P=0.500      P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    3/50 (6%)    5/50 (10%)  |2/50 (4%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/46.65      3/46.03      3/45.93      5/31.11     |2/47.18      3/44.43      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     10.7%        6.5%         6.5%         16.1%       |4.2%         6.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/38 (8%)    3/42 (7%)    2/39 (5%)    2/14 (14%)  |1/39 (3%)    1/32 (3%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     617          730 (T)      512          656         |653          665          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.088      P=0.316N     P=0.357N     P=0.156     |P=0.078N     P=0.424      P=0.245N     P=0.352N     | 
|POLY 3             |     P=0.311      P=0.364N     P=0.365N     P=0.370     |P=0.062N     P=0.473      P=0.238N     P=0.308N     | 
|POLY 1.5           |     P=0.345      P=0.370N     P=0.365N     P=0.450     |P=0.058N     P=0.484      P=0.239N     P=0.286N     | 
|POLY 6             |     P=0.290      P=0.356N     P=0.364N     P=0.298     |P=0.067N     P=0.459      P=0.237N     P=0.330N     | 
|LOGISTIC REGRESSION|     P=0.301      P=0.363N     P=0.337N     P=0.346     |P=0.052N     P=0.509      P=0.234N     P=0.270N     | 
|COCH-ARM / FISHERS |     P=0.467      P=0.357N     P=0.357N     P=0.630N    |P=0.051N     P=0.500      P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    3/50 (6%)    2/50 (4%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.19      3/46.03      3/45.28      2/31.46     |2/46.90      2/44.59      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         6.5%         6.6%         6.4%        |4.3%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    3/42 (7%)    3/39 (8%)    1/14 (7%)   |2/39 (5%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      730 (T)      211         |729 (T)      633          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.272      P=0.546      P=0.512      P=0.409     |P=0.101N     P=0.641      P=0.238N     P=0.361N     | 
|POLY 3             |     P=0.452      P=0.498      P=0.491      P=0.548     |P=0.081N     P=0.676      P=0.237N     P=0.306N     | 
|POLY 1.5           |     P=0.504      P=0.491      P=0.492      P=0.597     |P=0.078N     P=0.683      P=0.238N     P=0.285N     | 
|POLY 6             |     P=0.405      P=0.508      P=0.492      P=0.496     |P=0.085N     P=0.667      P=0.235N     P=0.327N     | 
|LOGISTIC REGRESSION|     P=0.567N     P=0.546      P=0.512      P=0.631N    |P=0.073N     P=0.689N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.521N     P=0.500      P=0.500      P=0.691N    |P=0.072N     P=0.691N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    5/50 (10%)   3/50 (6%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/46.19      2/46.03      5/45.28      3/31.13     |2/46.90      1/44.06      0/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |     10.8%        4.3%         11.0%        9.6%        |4.3%         2.3%         0.0%         2.8%         | 
|TERMINAL (d)       |     5/38 (13%)   2/42 (5%)    5/39 (13%)   1/14 (7%)   |2/39 (5%)    1/32 (3%)    0/39 (0%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      730 (T)      554         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.188      P=0.177N     P=0.615N     P=0.445     |P=0.487N     P=0.569N     P=0.238N     P=0.681N     | 
|POLY 3             |     P=0.426      P=0.218N     P=0.618      P=0.581N    |P=0.374N     P=0.522N     P=0.237N     P=0.598N     | 
|POLY 1.5           |     P=0.492      P=0.225N     P=0.619      P=0.511N    |P=0.374N     P=0.513N     P=0.238N     P=0.570N     | 
|POLY 6             |     P=0.369      P=0.209N     P=0.620      P=0.635     |P=0.374N     P=0.533N     P=0.235N     P=0.623N     | 
|LOGISTIC REGRESSION|     P=0.376      P=0.177N     P=0.615N     P=0.632N    |P=0.487N     P=0.569N     (e)          P=0.681N     | 
|COCH-ARM / FISHERS |     P=0.474N     P=0.218N     P=0.630N     P=0.357N    |P=0.373N     P=0.500N     P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  28/50 (56%)  32/50 (64%)  18/50 (36%) |4/50 (8%)    3/50 (6%)    2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     23/46.85     28/46.70     32/48.86     18/33.44    |4/46.90      3/44.43      2/47.14      4/35.62      | 
|POLY-3 PERCENT (g) |     49.1%        60.0%        65.5%        53.8%       |8.5%         6.8%         4.2%         11.2%        | 
|TERMINAL (d)       |     19/38 (50%)  26/42 (62%)  24/39 (62%)  10/14 (71%) |4/39 (10%)   1/32 (3%)    1/39 (3%)    2/23 (9%)    | 
|FIRST INCIDENCE    |     582          535          211          494         |729 (T)      665          695          640          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.369      P=0.088      P=0.008 **  |P=0.339      P=0.600N     P=0.335N     P=0.364      | 
|POLY 3             |     P=0.316      P=0.196      P=0.075      P=0.424     |P=0.451      P=0.529N     P=0.335N     P=0.486      | 
|POLY 1.5           |     P=0.520      P=0.177      P=0.064      P=0.578N    |P=0.468      P=0.518N     P=0.338N     P=0.531      | 
|POLY 6             |     P=0.179      P=0.221      P=0.093      P=0.268     |P=0.445      P=0.543N     P=0.330N     P=0.447      | 
|LOGISTIC REGRESSION|     P=0.409      P=0.209      P=0.053      P=0.254     |P=0.415      P=0.537N     P=0.331N     P=0.445      | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.212      P=0.054      P=0.208N    |P=0.546      P=0.500N     P=0.339N     P=0.643N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  39/50 (78%)  42/50 (84%)  19/50 (38%) |14/50 (28%)  6/50 (12%)   10/50 (20%)  5/50 (10%)   | 
|POLY-3 RATE (b)    |     41/47.61     39/46.10     42/46.80     19/32.37    |14/46.90     6/44.19      10/47.09     5/35.29      | 
|POLY-3 PERCENT (g) |     86.1%        84.6%        89.7%        58.7%       |29.9%        13.6%        21.2%        14.2%        | 
|TERMINAL (d)       |     37/38 (97%)  38/42 (91%)  38/39 (97%)  11/14 (79%) |14/39 (36%)  5/32 (16%)   9/39 (23%)   4/23 (17%)   | 
|FIRST INCIDENCE    |     528          714          512          410         |729 (T)      696          708          704          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.041 *    P=0.062N     P=0.606      P=0.222     |P=0.250N     P=0.097N     P=0.234N     P=0.193N     | 
|POLY 3             |     P=0.005N**   P=0.536N     P=0.404      P=0.002N**  |P=0.155N     P=0.050N     P=0.235N     P=0.081N     | 
|POLY 1.5           |     P<0.001N**   P=0.550N     P=0.417      P<0.001N**  |P=0.125N     P=0.045N*    P=0.241N     P=0.055N     | 
|POLY 6             |     P=0.060N     P=0.509N     P=0.420      P=0.020N*   |P=0.179N     P=0.057N     P=0.226N     P=0.112N     | 
|LOGISTIC REGRESSION|     P=0.090N     P=0.311N     P=0.364      P=0.054N    |P=0.220N     P=0.081N     P=0.207N     P=0.164N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.402N     P=0.500      P<0.001N**  |P=0.062N     P=0.039N*    P=0.241N     P=0.020N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  13/50 (26%)  13/50 (26%)  4/50 (8%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     10/46.26     13/46.03     13/45.71     4/31.78     |0/46.90      2/44.41      2/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |     21.6%        28.2%        28.4%        12.6%       |0.0%         4.5%         4.3%         2.8%         | 
|TERMINAL (d)       |     9/38 (24%)   13/42 (31%)  11/39 (28%)  1/14 (7%)   |0/39 (0%)    1/32 (3%)    2/39 (5%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     714          730 (T)      626          525         |---          633          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.500      P=0.416      P=0.338      P=0.591N    |P=0.382      P=0.214      P=0.238      P=0.395      | 
|POLY 3             |     P=0.247N     P=0.311      P=0.304      P=0.242N    |P=0.377      P=0.225      P=0.238      P=0.444      | 
|POLY 1.5           |     P=0.153N     P=0.297      P=0.303      P=0.176N    |P=0.409      P=0.230      P=0.237      P=0.460      | 
|POLY 6             |     P=0.354N     P=0.330      P=0.311      P=0.317N    |P=0.352      P=0.219      P=0.239      P=0.429      | 
|LOGISTIC REGRESSION|     P=0.259N     P=0.368      P=0.300      P=0.256N    |P=0.435      P=0.248      P=0.238      P=0.395      | 
|COCH-ARM / FISHERS |     P=0.039N*    P=0.318      P=0.318      P=0.074N    |P=0.515      P=0.247      P=0.247      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   4/50 (8%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/46.19      5/46.03      4/45.28      0/30.48     |0/46.90      1/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     10.8%        10.9%        8.8%         0.0%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/38 (13%)   5/42 (12%)   4/39 (10%)   0/14 (0%)   |0/39 (0%)    1/32 (3%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      730 (T)      ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.140N     P=0.567N     P=0.484N     P=0.187N    |P=0.528N     P=0.461      (e)          (e)          | 
|POLY 3             |     P=0.085N     P=0.628      P=0.513N     P=0.087N    |P=0.474N     P=0.488      (e)          (e)          | 
|POLY 1.5           |     P=0.056N     P=0.618      P=0.511N     P=0.063N    |P=0.463N     P=0.493      (e)          (e)          | 
|POLY 6             |     P=0.125N     P=0.619N     P=0.511N     P=0.117N    |P=0.492N     P=0.481      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.140N     P=0.567N     P=0.484N     (e)         |(e)          P=0.461      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.023N*    P=0.630N     P=0.500N     P=0.028N*   |P=0.468N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    5/50 (10%)   1/50 (2%)   |1/50 (2%)    3/50 (6%)    9/50 (18%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     1/46.19      2/46.68      5/45.28      1/30.48     |1/46.90      3/44.38      9/47.34      8/35.49      | 
|POLY-3 PERCENT (g) |     2.2%         4.3%         11.0%        3.3%        |2.1%         6.8%         19.0%        22.5%        | 
|TERMINAL (d)       |     1/38 (3%)    1/42 (2%)    5/39 (13%)   1/14 (7%)   |1/39 (3%)    2/32 (6%)    7/39 (18%)   7/23 (30%)   | 
|FIRST INCIDENCE    |     730 (T)      518          730 (T)      730 (T)     |729 (T)      643          646          649          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.196      P=0.521      P=0.109      P=0.525     |P<0.001 **   P=0.250      P=0.011 *    P<0.001 **   | 
|POLY 3             |     P=0.266      P=0.504      P=0.097      P=0.659     |P<0.001 **   P=0.286      P=0.008 **   P=0.004 **   | 
|POLY 1.5           |     P=0.345      P=0.496      P=0.098      P=0.694     |P=0.002 **   P=0.294      P=0.008 **   P=0.006 **   | 
|POLY 6             |     P=0.197      P=0.513      P=0.097      P=0.622     |P<0.001 **   P=0.276      P=0.009 **   P=0.003 **   | 
|LOGISTIC REGRESSION|     P=0.391      P=0.527      P=0.109      P=0.525     |P<0.001 **   P=0.293      P=0.010 *    P=0.002 **   | 
|COCH-ARM / FISHERS |     P=0.554      P=0.500      P=0.102      P=0.753N    |P=0.008 **   P=0.309      P=0.008 **   P=0.015 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   5/50 (10%)   4/50 (8%)   |1/50 (2%)    6/50 (12%)   4/50 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     1/46.19      5/46.19      5/45.28      4/32.18     |1/46.90      6/44.21      4/47.00      6/35.19      | 
|POLY-3 PERCENT (g) |     2.2%         10.8%        11.0%        12.4%       |2.1%         13.6%        8.5%         17.1%        | 
|TERMINAL (d)       |     1/38 (3%)    4/42 (10%)   5/39 (13%)   1/14 (7%)   |1/39 (3%)    4/32 (13%)   4/39 (10%)   6/23 (26%)   | 
|FIRST INCIDENCE    |     730 (T)      689          730 (T)      283         |729 (T)      696          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.031 *    P=0.128      P=0.109      P=0.048 *   |P=0.035 *    P=0.035 *    P=0.179      P=0.008 **   | 
|POLY 3             |     P=0.124      P=0.101      P=0.097      P=0.092     |P=0.071      P=0.047 *    P=0.180      P=0.023 *    | 
|POLY 1.5           |     P=0.161      P=0.098      P=0.098      P=0.114     |P=0.085      P=0.051      P=0.178      P=0.030 *    | 
|POLY 6             |     P=0.096      P=0.107      P=0.097      P=0.073     |P=0.061      P=0.043 *    P=0.182      P=0.017 *    | 
|LOGISTIC REGRESSION|     P=0.219      P=0.105      P=0.109      P=0.230     |P=0.039 *    P=0.039 *    P=0.179      P=0.008 **   | 
|COCH-ARM / FISHERS |     P=0.295      P=0.102      P=0.102      P=0.181     |P=0.149      P=0.056      P=0.181      P=0.056      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  24/50 (48%)  16/50 (32%)  4/50 (8%)   |5/50 (10%)   3/50 (6%)    6/50 (12%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     19/46.94     24/46.64     16/45.28     4/31.14     |5/47.06      3/45.25      6/47.14      5/36.63      | 
|POLY-3 PERCENT (g) |     40.5%        51.5%        35.3%        12.9%       |10.6%        6.6%         12.7%        13.7%        | 
|TERMINAL (d)       |     18/38 (47%)  23/42 (55%)  16/39 (41%)  1/14 (7%)   |3/39 (8%)    1/32 (3%)    4/39 (10%)   3/23 (13%)   | 
|FIRST INCIDENCE    |     464          535          730 (T)      554         |708          354          708          382          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.044N*    P=0.337      P=0.294N     P=0.129N    |P=0.190      P=0.447N     P=0.516      P=0.341      | 
|POLY 3             |     P=0.003N**   P=0.194      P=0.384N     P=0.009N**  |P=0.253      P=0.378N     P=0.501      P=0.467      | 
|POLY 1.5           |     P<0.001N**   P=0.178      P=0.374N     P=0.003N**  |P=0.285      P=0.368N     P=0.498      P=0.513      | 
|POLY 6             |     P=0.010N*    P=0.219      P=0.385N     P=0.023N*   |P=0.232      P=0.393N     P=0.506      P=0.424      | 
|LOGISTIC REGRESSION|     P=0.003N**   P=0.196      P=0.358N     P=0.014N*   |P=0.419      P=0.301N     P=0.505      P=0.588      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.210      P=0.338N     P<0.001N**  |P=0.401      P=0.357N     P=0.500      P=0.630N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   10/50 (20%)  4/50 (8%)   |9/50 (18%)   7/50 (14%)   18/50 (36%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |     5/46.44      5/46.10      10/45.28     4/30.64     |9/46.90      7/44.06      18/47.31     11/35.49     | 
|POLY-3 PERCENT (g) |     10.8%        10.9%        22.1%        13.1%       |19.2%        15.9%        38.1%        31.0%        | 
|TERMINAL (d)       |     4/38 (11%)   4/42 (10%)   10/39 (26%)  2/14 (14%)  |9/39 (23%)   7/32 (22%)   17/39 (44%)  10/23 (44%)  | 
|FIRST INCIDENCE    |     664          714          730 (T)      695         |729 (T)      729 (T)      646          649          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.059      P=0.572N     P=0.141      P=0.248     |P=0.008 **   P=0.565N     P=0.031 *    P=0.048 *    | 
|POLY 3             |     P=0.213      P=0.625      P=0.117      P=0.521     |P=0.026 *    P=0.445N     P=0.034 *    P=0.167      | 
|POLY 1.5           |     P=0.313      P=0.616      P=0.120      P=0.602     |P=0.044 *    P=0.424N     P=0.033 *    P=0.224      | 
|POLY 6             |     P=0.138      P=0.623N     P=0.116      P=0.438     |P=0.017 *    P=0.474N     P=0.036 *    P=0.123      | 
|LOGISTIC REGRESSION|     P=0.145      P=0.628N     P=0.123      P=0.405     |P=0.013 *    P=0.565N     P=0.038 *    P=0.072      | 
|COCH-ARM / FISHERS |     P=0.528N     P=0.630N     P=0.131      P=0.500N    |P=0.154      P=0.393N     P=0.035 *    P=0.402      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    4/50 (8%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.19      2/46.03      1/45.39      1/30.76     |1/47.44      4/44.21      3/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         4.3%         2.2%         3.3%        |2.1%         9.1%         6.4%         2.8%         | 
|TERMINAL (d)       |     2/38 (5%)    2/42 (5%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    2/32 (6%)    3/39 (8%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      702          656         |562          696          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.595N     P=0.658N     P=0.494N     P=0.693     |P=0.530N     P=0.140      P=0.305      P=0.665      | 
|POLY 3             |     P=0.420N     P=0.692      P=0.506N     P=0.635N    |P=0.508N     P=0.158      P=0.302      P=0.689      | 
|POLY 1.5           |     P=0.382N     P=0.687      P=0.506N     P=0.594N    |P=0.463N     P=0.167      P=0.302      P=0.711      | 
|POLY 6             |     P=0.453N     P=0.687N     P=0.504N     P=0.673N    |P=0.552N     P=0.148      P=0.303      P=0.667      | 
|LOGISTIC REGRESSION|     P=0.462N     P=0.658N     P=0.506N     P=0.669N    |P=0.446N     P=0.189      P=0.311      P=0.766N     | 
|COCH-ARM / FISHERS |     P=0.321N     P=0.691N     P=0.500N     P=0.500N    |P=0.361N     P=0.181      P=0.309      P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.19      1/46.03      2/45.28      0/30.48     |0/46.90      0/44.06      1/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         4.4%         0.0%        |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    1/42 (2%)    2/39 (5%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      730 (T)      ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.453N     P=0.465N     P=0.686N     P=0.475N    |P=0.610      (e)          P=0.500      (e)          | 
|POLY 3             |     P=0.366N     P=0.501N     P=0.687      P=0.340N    |P=0.526      (e)          P=0.500      (e)          | 
|POLY 1.5           |     P=0.306N     P=0.507N     P=0.687      P=0.305N    |P=0.555      (e)          P=0.500      (e)          | 
|POLY 6             |     P=0.432N     P=0.494N     P=0.688      P=0.377N    |P=0.508      (e)          P=0.502      (e)          | 
|LOGISTIC REGRESSION|     P=0.453N     P=0.465N     P=0.686N     (e)         |(e)          (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.222N     P=0.500N     P=0.691N     P=0.247N    |P=0.656      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     25/50 (50%)  33/50 (66%)  33/50 (66%)  11/50 (22%) |42/50 (84%)  34/50 (68%)  40/50 (80%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     25/46.29     33/47.60     33/45.93     11/31.52    |42/47.95     34/45.74     40/47.70     32/40.43     | 
|POLY-3 PERCENT (g) |     54.0%        69.3%        71.9%        34.9%       |87.6%        74.3%        83.9%        79.2%        | 
|TERMINAL (d)       |     23/38 (61%)  29/42 (69%)  32/39 (82%)  8/14 (57%)  |36/39 (92%)  30/32 (94%)  36/39 (92%)  20/23 (87%)  | 
|FIRST INCIDENCE    |     712          518          512          494         |653          468          645          352          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.273      P=0.191      P=0.073      P=0.414     |P=0.038 *    P=0.517N     P=0.394N     P=0.080      | 
|POLY 3             |     P=0.093N     P=0.090      P=0.052      P=0.075N    |P=0.391N     P=0.069N     P=0.405N     P=0.199N     | 
|POLY 1.5           |     P=0.018N*    P=0.067      P=0.057      P=0.030N*   |P=0.297N     P=0.056N     P=0.414N     P=0.117N     | 
|POLY 6             |     P=0.290N     P=0.127      P=0.051      P=0.165N    |P=0.454N     P=0.100N     P=0.397N     P=0.302N     | 
|LOGISTIC REGRESSION|     P=0.147N     P=0.068      P=0.050      P=0.289N    |P=0.373      P=0.147N     P=0.348N     P=0.395N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.078      P=0.078      P=0.003N**  |P=0.067N     P=0.050N     P=0.398N     P=0.020N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   13/50 (26%)  13/50 (26%)  3/50 (6%)   |3/50 (6%)    15/50 (30%)  16/50 (32%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     9/46.19      13/46.19     13/45.28     3/30.62     |3/46.98      15/44.83     16/47.70     13/36.26     | 
|POLY-3 PERCENT (g) |     19.5%        28.1%        28.7%        9.8%        |6.4%         33.5%        33.5%        35.9%        | 
|TERMINAL (d)       |     9/38 (24%)   12/42 (29%)  13/39 (33%)  2/14 (14%)  |2/39 (5%)    12/32 (38%)  12/39 (31%)  11/23 (48%)  | 
|FIRST INCIDENCE    |     730 (T)      689          730 (T)      695         |708          643          645          547          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.559N     P=0.319      P=0.248      P=0.558N    |P=0.003 **   P<0.001 **   P=0.002 **   P<0.001 **   | 
|POLY 3             |     P=0.249N     P=0.232      P=0.215      P=0.213N    |P=0.007 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.140N     P=0.219      P=0.218      P=0.150N    |P=0.013 *    P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.386N     P=0.251      P=0.216      P=0.293N    |P=0.004 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.371N     P=0.268      P=0.248      P=0.394N    |P=0.008 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.030N*    P=0.235      P=0.235      P=0.061N    |P=0.065      P=0.002 **   P<0.001 **   P=0.006 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    10/50 (20%)  5/50 (10%)   0/50 (0%)   |1/50 (2%)    3/50 (6%)    3/50 (6%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     4/47.27      10/48.51     5/45.56      0/30.48     |1/47.18      3/44.62      3/47.00      6/36.43      | 
|POLY-3 PERCENT (g) |     8.5%         20.6%        11.0%        0.0%        |2.1%         6.7%         6.4%         16.5%        | 
|TERMINAL (d)       |     1/38 (3%)    5/42 (12%)   3/39 (8%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    3/39 (8%)    2/23 (9%)    | 
|FIRST INCIDENCE    |     528          4            685          ---         |653          665          729 (T)      513          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.082N     P=0.102      P=0.500      P=0.189N    |P=0.010 *    P=0.261      P=0.303      P=0.017 *    | 
|POLY 3             |     P=0.070N     P=0.080      P=0.477      P=0.141N    |P=0.021 *    P=0.286      P=0.304      P=0.025 *    | 
|POLY 1.5           |     P=0.039N*    P=0.075      P=0.482      P=0.109N    |P=0.024 *    P=0.294      P=0.304      P=0.032 *    | 
|POLY 6             |     P=0.117N     P=0.088      P=0.475      P=0.181N    |P=0.019 *    P=0.277      P=0.305      P=0.021 *    | 
|LOGISTIC REGRESSION|     P=0.004N**   P=0.113      P=0.523      P=0.050N    |P=0.031 *    P=0.331      P=0.305      P=0.042 *    | 
|COCH-ARM / FISHERS |     P=0.011N*    P=0.074      P=0.500      P=0.059N    |P=0.042 *    P=0.309      P=0.309      P=0.056      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    3/50 (6%)    0/50 (0%)   |6/50 (12%)   18/50 (36%)  13/50 (26%)  1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.19      4/46.19      3/45.28      0/30.48     |6/47.16      18/44.95     13/47.09     1/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         8.7%         6.6%         0.0%        |12.7%        40.1%        27.6%        2.8%         | 
|TERMINAL (d)       |     0/38 (0%)    3/42 (7%)    3/39 (8%)    0/14 (0%)   |5/39 (13%)   14/32 (44%)  11/39 (28%)  1/23 (4%)    | 
|FIRST INCIDENCE    |     ---          689          730 (T)      ---         |659          648          716          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.588N     P=0.077      P=0.126      (e)         |P=0.048N*    P<0.001 **   P=0.067      P=0.182N     | 
|POLY 3             |     P=0.515N     P=0.060      P=0.115      (e)         |P=0.044N*    P=0.002 **   P=0.059      P=0.120N     | 
|POLY 1.5           |     P=0.427N     P=0.058      P=0.116      (e)         |P=0.024N*    P=0.003 **   P=0.059      P=0.098N     | 
|POLY 6             |     P=0.600      P=0.063      P=0.116      (e)         |P=0.074N     P=0.002 **   P=0.060      P=0.146N     | 
|LOGISTIC REGRESSION|     P=0.489N     P=0.062      P=0.126      (e)         |P=0.029N*    P=0.002 **   P=0.066      P=0.138N     | 
|COCH-ARM / FISHERS |     P=0.279N     P=0.059      P=0.121      (e)         |P=0.006N**   P=0.005 **   P=0.062      P=0.056N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  30/50 (60%)  23/50 (46%)  17/50 (34%) |9/50 (18%)   12/50 (24%)  15/50 (30%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     18/46.94     30/46.19     23/45.82     17/35.05    |9/48.35      12/44.80     15/47.00     21/39.05     | 
|POLY-3 PERCENT (g) |     38.4%        65.0%        50.2%        48.5%       |18.6%        26.8%        31.9%        53.8%        | 
|TERMINAL (d)       |     17/38 (45%)  29/42 (69%)  22/39 (56%)  8/14 (57%)  |5/39 (13%)   11/32 (34%)  15/39 (39%)  15/23 (65%)  | 
|FIRST INCIDENCE    |     464          689          563          410         |338          468          729 (T)      352          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005 **   P=0.031 *    P=0.224      P=0.005 **  |P<0.001 **   P=0.180      P=0.127      P<0.001 **   | 
|POLY 3             |     P=0.504      P=0.007 **   P=0.171      P=0.244     |P<0.001 **   P=0.244      P=0.103      P<0.001 **   | 
|POLY 1.5           |     P=0.416N     P=0.007 **   P=0.178      P=0.350     |P<0.001 **   P=0.270      P=0.107      P<0.001 **   | 
|POLY 6             |     P=0.385      P=0.008 **   P=0.172      P=0.168     |P<0.001 **   P=0.211      P=0.099      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.401      P=0.013 *    P=0.180      P=0.284     |P<0.001 **   P=0.338      P=0.121      P=0.004 **   | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.014 *    P=0.208      P=0.500N    |P=0.004 **   P=0.312      P=0.121      P=0.008 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Infiltration Cellular Lymphocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      0/46.03      0/45.28      0/30.48     |2/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |2/39 (5%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.186N     P=0.283N     P=0.238N     P=0.361N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.137N     P=0.251N     P=0.237N     P=0.306N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.139N     P=0.246N     P=0.238N     P=0.285N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.136N     P=0.259N     P=0.235N     P=0.327N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.186N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.152N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Erythrophagocytosis                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.19      0/46.03      2/45.28      0/30.48     |1/47.09      0/44.06      0/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.4%         0.0%        |2.1%         0.0%         0.0%         2.8%         | 
|TERMINAL (d)       |     1/38 (3%)    0/42 (0%)    2/39 (5%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     730 (T)      ---          730 (T)      ---         |677          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.591      P=0.480N     P=0.509      P=0.699N    |P=0.466      P=0.529N     P=0.496N     P=0.648      | 
|POLY 3             |     P=0.586      P=0.501N     P=0.493      P=0.580N    |P=0.523      P=0.513N     P=0.500N     P=0.691      | 
|POLY 1.5           |     P=0.619N     P=0.504N     P=0.494      P=0.555N    |P=0.518      P=0.508N     P=0.501N     P=0.713      | 
|POLY 6             |     P=0.533      P=0.496N     P=0.494      P=0.604N    |P=0.539      P=0.520N     P=0.500N     P=0.670      | 
|LOGISTIC REGRESSION|     P=0.591      (e)          P=0.509      (e)         |P=0.509      P=0.486N     P=0.493N     P=0.711      | 
|COCH-ARM / FISHERS |     P=0.519N     P=0.500N     P=0.500      P=0.500N    |P=0.545      P=0.500N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.19      2/47.19      0/45.28      1/31.48     |0/46.90      2/44.38      0/47.00      2/36.22      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         3.2%        |0.0%         4.5%         0.0%         5.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          3            ---          114         |---          683          ---          113          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.578      P=0.247      (e)          P=0.492     |P=0.235      P=0.207      (e)          P=0.187      | 
|POLY 3             |     P=0.571      P=0.242      (e)          P=0.426     |P=0.266      P=0.225      (e)          P=0.185      | 
|POLY 1.5           |     P=0.570      P=0.238      (e)          P=0.450     |P=0.275      P=0.230      (e)          P=0.200      | 
|POLY 6             |     P=0.580      P=0.248      (e)          P=0.402     |P=0.267      P=0.219      (e)          P=0.172      | 
|LOGISTIC REGRESSION|     P=0.342N     P=0.469      (e)          (e)         |P=0.563      P=0.244      (e)          P=0.508      | 
|COCH-ARM / FISHERS |     P=0.628      P=0.247      (e)          P=0.500     |P=0.313      P=0.247      (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/46.27      1/46.03      3/45.28      0/30.48     |1/46.90      3/44.28      1/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |     8.7%         2.2%         6.6%         0.0%        |2.1%         6.8%         2.1%         2.8%         | 
|TERMINAL (d)       |     3/38 (8%)    1/42 (2%)    3/39 (8%)    0/14 (0%)   |1/39 (3%)    2/32 (6%)    1/39 (3%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     712          730 (T)      730 (T)      ---         |729 (T)      673          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.295N     P=0.157N     P=0.492N     P=0.242N    |P=0.511N     P=0.244      P=0.762      P=0.639      | 
|POLY 3             |     P=0.218N     P=0.180N     P=0.512N     P=0.135N    |P=0.443N     P=0.285      P=0.760N     P=0.692      | 
|POLY 1.5           |     P=0.166N     P=0.185N     P=0.510N     P=0.106N    |P=0.421N     P=0.293      P=0.760      P=0.713      | 
|POLY 6             |     P=0.279N     P=0.174N     P=0.511N     P=0.172N    |P=0.465N     P=0.275      P=0.758N     P=0.672      | 
|LOGISTIC REGRESSION|     P=0.241N     P=0.169N     P=0.504N     P=0.181N    |P=0.477N     P=0.280      P=0.762      P=0.639      | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.181N     P=0.500N     P=0.059N    |P=0.370N     P=0.309      P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.19      0/46.03      2/45.39      0/30.48     |0/46.90      0/44.06      1/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.4%         0.0%        |0.0%         0.0%         2.1%         2.8%         | 
|TERMINAL (d)       |     1/38 (3%)    0/42 (0%)    1/39 (3%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    1/39 (3%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     730 (T)      ---          702          ---         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.605      P=0.480N     P=0.506      P=0.699N    |P=0.137      (e)          P=0.500      P=0.395      | 
|POLY 3             |     P=0.586      P=0.501N     P=0.494      P=0.580N    |P=0.153      (e)          P=0.500      P=0.444      | 
|POLY 1.5           |     P=0.619N     P=0.504N     P=0.494      P=0.555N    |P=0.163      (e)          P=0.500      P=0.460      | 
|POLY 6             |     P=0.533      P=0.496N     P=0.496      P=0.604N    |P=0.148      (e)          P=0.502      P=0.429      | 
|LOGISTIC REGRESSION|     P=0.663      (e)          P=0.494      (e)         |(e)          (e)          P=0.500      P=0.395      | 
|COCH-ARM / FISHERS |     P=0.519N     P=0.500N     P=0.500      P=0.500N    |P=0.212      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      0/46.03      0/45.28      0/30.48     |0/46.90      2/45.21      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          424          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.322N     P=0.235      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.311N     P=0.229      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.233      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.328N     P=0.224      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.112N     P=0.293      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.284N     P=0.247      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    5/50 (10%)   6/50 (12%)  |2/50 (4%)    2/50 (4%)    4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/46.82      3/46.03      5/45.28      6/31.45     |2/47.18      2/44.06      4/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     8.5%         6.5%         11.0%        19.1%       |4.2%         4.5%         8.5%         0.0%         | 
|TERMINAL (d)       |     3/38 (8%)    3/42 (7%)    5/39 (13%)   3/14 (21%)  |1/39 (3%)    2/32 (6%)    4/39 (10%)   0/23 (0%)    | 
|FIRST INCIDENCE    |     528          730 (T)      730 (T)      410         |653          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   P=0.457N     P=0.510      P=0.046 *   |P=0.381N     P=0.627      P=0.335      P=0.352N     | 
|POLY 3             |     P=0.080      P=0.509N     P=0.479      P=0.161     |P=0.386N     P=0.669      P=0.336      P=0.308N     | 
|POLY 1.5           |     P=0.106      P=0.515N     P=0.484      P=0.217     |P=0.340N     P=0.679      P=0.335      P=0.286N     | 
|POLY 6             |     P=0.063      P=0.501N     P=0.477      P=0.115     |P=0.432N     P=0.655      P=0.337      P=0.330N     | 
|LOGISTIC REGRESSION|     P=0.081      P=0.502N     P=0.494      P=0.222     |P=0.345N     P=0.682      P=0.337      P=0.270N     | 
|COCH-ARM / FISHERS |     P=0.202      P=0.500N     P=0.500      P=0.370     |P=0.243N     P=0.691N     P=0.339      P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    4/50 (8%)    0/50 (0%)   |2/50 (4%)    3/50 (6%)    4/50 (8%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/46.19      0/46.03      4/45.39      0/30.48     |2/47.18      3/44.52      4/47.31      4/35.19      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         8.8%         0.0%        |4.2%         6.7%         8.5%         11.4%        | 
|TERMINAL (d)       |     1/38 (3%)    0/42 (0%)    3/39 (8%)    0/14 (0%)   |0/39 (0%)    1/32 (3%)    3/39 (8%)    4/23 (17%)   | 
|FIRST INCIDENCE    |     730 (T)      ---          702          ---         |677          647          645          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.351      P=0.480N     P=0.188      P=0.699N    |P=0.113      P=0.432      P=0.348      P=0.142      | 
|POLY 3             |     P=0.345      P=0.501N     P=0.173      P=0.580N    |P=0.155      P=0.474      P=0.339      P=0.216      | 
|POLY 1.5           |     P=0.430      P=0.504N     P=0.174      P=0.555N    |P=0.178      P=0.484      P=0.337      P=0.249      | 
|POLY 6             |     P=0.263      P=0.496N     P=0.175      P=0.604N    |P=0.139      P=0.460      P=0.342      P=0.187      | 
|LOGISTIC REGRESSION|     P=0.431      (e)          P=0.174      (e)         |P=0.167      P=0.515      P=0.338      P=0.182      | 
|COCH-ARM / FISHERS |     P=0.601N     P=0.500N     P=0.181      P=0.500N    |P=0.267      P=0.500      P=0.339      P=0.339      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/47 (2%)    5/47 (11%)   4/47 (9%)   |4/49 (8%)    7/49 (14%)   12/47 (26%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     1/45.27      1/43.26      5/43.11      4/30.10     |4/45.90      7/43.45      12/44.22     9/36.46      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         11.6%        13.3%       |8.7%         16.1%        27.1%        24.7%        | 
|TERMINAL (d)       |     0/37 (0%)    1/41 (2%)    4/38 (11%)   1/14 (7%)   |4/38 (11%)   5/32 (16%)   10/38 (26%)  7/23 (30%)   | 
|FIRST INCIDENCE    |     712          730 (T)      512          494         |729 (T)      665          711          494          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   P=0.746N     P=0.109      P=0.048 *   |P=0.011 *    P=0.175      P=0.030 *    P=0.017 *    | 
|POLY 3             |     P=0.016 *    P=0.750      P=0.090      P=0.083     |P=0.025 *    P=0.230      P=0.020 *    P=0.047 *    | 
|POLY 1.5           |     P=0.023 *    P=0.747      P=0.090      P=0.103     |P=0.037 *    P=0.242      P=0.020 *    P=0.063      | 
|POLY 6             |     P=0.011 *    P=0.756      P=0.092      P=0.067     |P=0.018 *    P=0.215      P=0.021 *    P=0.036 *    | 
|LOGISTIC REGRESSION|     P=0.047 *    P=0.755      P=0.097      P=0.148     |P=0.025 *    P=0.203      P=0.025 *    P=0.050      | 
|COCH-ARM / FISHERS |     P=0.060      P=0.742      P=0.093      P=0.168     |P=0.104      P=0.262      P=0.021 *    P=0.125      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    4/50 (8%)    5/50 (10%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/46.19      1/46.03      1/45.28      0/30.48     |2/46.98      4/44.54      5/47.14      4/36.44      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.2%         0.0%        |4.3%         9.0%         10.6%        11.0%        | 
|TERMINAL (d)       |     0/38 (0%)    1/42 (2%)    1/39 (3%)    0/14 (0%)   |1/39 (3%)    2/32 (6%)    4/39 (10%)   1/23 (4%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      730 (T)      ---         |708          633          695          513          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      P=0.520      P=0.505      (e)         |P=0.153      P=0.266      P=0.227      P=0.173      | 
|POLY 3             |     P=0.659      P=0.499      P=0.496      (e)         |P=0.193      P=0.313      P=0.218      P=0.230      | 
|POLY 1.5           |     P=0.618N     P=0.496      P=0.496      (e)         |P=0.221      P=0.323      P=0.216      P=0.257      | 
|POLY 6             |     P=0.630      P=0.504      P=0.497      (e)         |P=0.175      P=0.301      P=0.221      P=0.208      | 
|LOGISTIC REGRESSION|     (e)          P=0.520      P=0.505      (e)         |P=0.269      P=0.329      P=0.218      P=0.318      | 
|COCH-ARM / FISHERS |     P=0.545N     P=0.500      P=0.500      (e)         |P=0.325      P=0.339      P=0.218      P=0.339      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/49 (0%)    2/48 (4%)   |1/50 (2%)    0/49 (0%)    2/50 (4%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/44.80      0/44.28      2/29.58     |1/46.90      0/43.20      2/47.00      0/33.60      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         6.8%        |2.1%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/38 (0%)    1/14 (7%)   |1/39 (3%)    0/32 (0%)    2/39 (5%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          588         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.009 **   (e)          (e)          P=0.093     |P=0.639N     P=0.539N     P=0.500      P=0.614N     | 
|POLY 3             |     P=0.042 *    (e)          (e)          P=0.160     |P=0.616N     P=0.516N     P=0.501      P=0.565N     | 
|POLY 1.5           |     P=0.037 *    (e)          (e)          P=0.181     |P=0.591N     P=0.511N     P=0.499      P=0.551N     | 
|POLY 6             |     P=0.051      (e)          (e)          P=0.142     |P=0.616      P=0.523N     P=0.503      P=0.578N     | 
|LOGISTIC REGRESSION|     P=0.036 *    (e)          (e)          P=0.187     |P=0.639N     (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |P=0.533N     P=0.505N     P=0.500      P=0.515N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/48 (0%)    0/49 (0%)    2/48 (4%)   |1/50 (2%)    1/49 (2%)    1/50 (2%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     1/44.63      0/44.80      0/44.28      2/29.58     |1/46.90      1/43.33      1/47.06      0/33.60      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         6.8%        |2.1%         2.3%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/38 (0%)    1/14 (7%)   |1/39 (3%)    0/32 (0%)    0/39 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     723          ---          ---          588         |729 (T)      696          715          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.076      P=0.490N     P=0.505N     P=0.239     |P=0.384N     P=0.715      P=0.752N     P=0.614N     | 
|POLY 3             |     P=0.207      P=0.499N     P=0.502N     P=0.363     |P=0.365N     P=0.743      P=0.760N     P=0.565N     | 
|POLY 1.5           |     P=0.195      P=0.503N     P=0.500N     P=0.404     |P=0.348N     P=0.748      P=0.760      P=0.551N     | 
|POLY 6             |     P=0.228      P=0.495N     P=0.502N     P=0.325     |P=0.385N     P=0.736      P=0.758N     P=0.578N     | 
|LOGISTIC REGRESSION|     P=0.175      P=0.497N     P=0.502N     P=0.399     |P=0.361N     P=0.748      P=0.761N     (e)          | 
|COCH-ARM / FISHERS |     P=0.214      P=0.500N     P=0.495N     P=0.500     |P=0.314N     P=0.747      P=0.753N     P=0.515N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/48 (8%)    1/48 (2%)    0/49 (0%)    0/48 (0%)   |3/50 (6%)    1/49 (2%)    3/50 (6%)    1/47 (2%)    | 
|POLY-3 RATE (b)    |     4/44.60      1/44.80      0/44.28      0/29.10     |3/46.90      1/43.33      3/47.00      1/33.86      | 
|POLY-3 PERCENT (g) |     9.0%         2.2%         0.0%         0.0%        |6.4%         2.3%         6.4%         3.0%         | 
|TERMINAL (d)       |     4/38 (11%)   1/42 (2%)    0/38 (0%)    0/14 (0%)   |3/39 (8%)    0/32 (0%)    3/39 (8%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          ---         |729 (T)      696          729 (T)      660          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061N     P=0.151N     P=0.063N     P=0.251N    |P=0.536N     P=0.380N     P=0.664      P=0.508N     | 
|POLY 3             |     P=0.033N*    P=0.177N     P=0.061N     P=0.137N    |P=0.477N     P=0.334N     P=0.661N     P=0.429N     | 
|POLY 1.5           |     P=0.028N*    P=0.183N     P=0.060N     P=0.107N    |P=0.454N     P=0.326N     P=0.661      P=0.401N     | 
|POLY 6             |     P=0.037N*    P=0.170N     P=0.061N     P=0.174N    |P=0.499N     P=0.345N     P=0.658N     P=0.455N     | 
|LOGISTIC REGRESSION|     P=0.061N     P=0.151N     (e)          (e)         |P=0.489N     P=0.348N     P=0.664      P=0.437N     | 
|COCH-ARM / FISHERS |     P=0.026N*    P=0.181N     P=0.056N     P=0.059N    |P=0.384N     P=0.316N     P=0.661N     P=0.332N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/48 (0%)    0/49 (0%)    1/48 (2%)   |1/50 (2%)    2/49 (4%)    0/50 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     1/44.60      0/44.80      0/44.28      1/29.58     |1/46.90      2/43.55      0/47.00      0/33.60      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         3.4%        |2.1%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    0/42 (0%)    0/38 (0%)    0/14 (0%)   |1/39 (3%)    1/32 (3%)    0/39 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      ---          ---          588         |729 (T)      633          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.395      P=0.480N     P=0.500N     P=0.581     |P=0.186N     P=0.449      P=0.500N     P=0.614N     | 
|POLY 3             |     P=0.530      P=0.499N     P=0.501N     P=0.661     |P=0.160N     P=0.474      P=0.500N     P=0.565N     | 
|POLY 1.5           |     P=0.515      P=0.503N     P=0.500N     P=0.694     |P=0.155N     P=0.482      P=0.500N     P=0.551N     | 
|POLY 6             |     P=0.553      P=0.494N     P=0.502N     P=0.626     |P=0.168N     P=0.465      P=0.498N     P=0.578N     | 
|LOGISTIC REGRESSION|     P=0.560      (e)          (e)          P=0.755     |P=0.153N     P=0.497      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.546      P=0.500N     P=0.495N     P=0.753N    |P=0.147N     P=0.492      P=0.500N     P=0.515N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/8 (0%)     0/6 (0%)     2/8 (25%)    0/3 (0%)    |0/9 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/7.69       0/5.84       2/7.35       0/2.07      |0/8.46       0/8.78       0/9.56       0/8.57       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         27.2%        0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     0/5 (0%)     0/5 (0%)     0/0 (0%)    |0/7 (0%)     0/7 (0%)     0/8 (0%)     0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          685          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.404      (e)          P=0.242      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.226      (e)          P=0.210      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.277      (e)          P=0.214      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.174      (e)          P=0.209      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.416      (e)          P=0.242      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.385      (e)          P=0.233      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/8 (25%)    3/6 (50%)    4/8 (50%)    2/3 (67%)   |5/9 (56%)    7/10 (70%)   8/10 (80%)   6/10 (60%)   | 
|POLY-3 RATE (b)    |     2/7.69       3/5.84       4/7.35       2/2.78      |5/8.74       7/9.66       8/9.87       6/8.76       | 
|POLY-3 PERCENT (g) |     26.0%        51.4%        54.4%        71.9%       |57.2%        72.5%        81.1%        68.5%        | 
|TERMINAL (d)       |     2/6 (33%)    3/5 (60%)    2/5 (40%)    0/0 (0%)    |4/7 (57%)    5/7 (71%)    7/8 (88%)    5/5 (100%)   | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      685          525         |653          468          646          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    P=0.396      P=0.268      P=0.113     |P=0.158      P=0.321      P=0.283      P=0.176      | 
|POLY 3             |     P=0.168      P=0.354      P=0.278      P=0.266     |P=0.420      P=0.423      P=0.270      P=0.502      | 
|POLY 1.5           |     P=0.181      P=0.352      P=0.288      P=0.276     |P=0.486      P=0.427      P=0.266      P=0.547      | 
|POLY 6             |     P=0.151      P=0.357      P=0.276      P=0.249     |P=0.330      P=0.420      P=0.276      P=0.434      | 
|LOGISTIC REGRESSION|     P=0.155      P=0.396      P=0.247      P=0.526     |P=0.526      P=0.447      P=0.266      P=0.429      | 
|COCH-ARM / FISHERS |     P=0.190      P=0.343      P=0.304      P=0.279     |P=0.572      P=0.430      P=0.259      P=0.605      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    4/50 (8%)    7/50 (14%)  |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/46.47      1/46.03      4/45.45      7/31.87     |1/46.90      0/44.06      0/47.00      1/35.19      | 
|POLY-3 PERCENT (g) |     8.6%         2.2%         8.8%         22.0%       |2.1%         0.0%         0.0%         2.8%         | 
|TERMINAL (d)       |     2/38 (5%)    1/42 (2%)    2/39 (5%)    1/14 (7%)   |1/39 (3%)    0/32 (0%)    0/39 (0%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     664          730 (T)      702          505         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.161N     P=0.636N     P=0.024 *   |P=0.460      P=0.539N     P=0.500N     P=0.639      | 
|POLY 3             |     P=0.021 *    P=0.182N     P=0.631      P=0.095     |P=0.523      P=0.512N     P=0.500N     P=0.692      | 
|POLY 1.5           |     P=0.027 *    P=0.186N     P=0.632      P=0.134     |P=0.518      P=0.507N     P=0.500N     P=0.713      | 
|POLY 6             |     P=0.017 *    P=0.176N     P=0.632      P=0.067     |P=0.539      P=0.519N     P=0.498N     P=0.672      | 
|LOGISTIC REGRESSION|     P=0.016 *    P=0.182N     P=0.634      P=0.103     |P=0.460      (e)          (e)          P=0.639      | 
|COCH-ARM / FISHERS |     P=0.056      P=0.181N     P=0.643N     P=0.262     |P=0.545      P=0.500N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/2 (100%)   0/0 (0%)     3/4 (75%)    0/1 (0%)    |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     2/2.00       0/0.00       3/4.00       0/0.94      |0/0.00       0/1.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     100.0%       0.0%         75.0%        0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     3/4 (75%)    0/0 (0%)    |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     714          ---          730 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.225N     (e)          P=0.245N     P=0.457N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          P=0.631N     P=1.000N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          P=0.631N     P=1.000N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          P=0.631N     P=1.000N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.153N     (e)          P=0.245N     P=0.379N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.152N     (e)          P=0.667N     P=0.333N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/2 (100%)   0/0 (0%)     4/4 (100%)   1/1 (100%)  |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     2/2.00       0/0.00       4/4.00       1/1.00      |0/0.00       0/1.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     100.0%       0.0%         100.0%       100.0%      |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     4/4 (100%)   0/0 (0%)    |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     714          ---          730 (T)      716         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |1/47.16      1/44.24      2/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |                                                        |2.1%         2.3%         4.3%         0.0%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/32 (0%)    2/39 (5%)    0/23 (0%)    | 
|FIRST INCIDENCE    |                                                        |659          683          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.480N     P=0.731      P=0.497      P=0.585N     | 
|POLY 3             |                                                        |P=0.476N     P=0.746      P=0.499      P=0.557N     | 
|POLY 1.5           |                                                        |P=0.442N     P=0.752      P=0.498      P=0.541N     | 
|POLY 6             |                                                        |P=0.512N     P=0.739      P=0.500      P=0.573N     | 
|LOGISTIC REGRESSION|                                                        |P=0.413N     P=0.746N     P=0.500      P=0.502N     | 
|COCH-ARM / FISHERS |                                                        |P=0.373N     P=0.753N     P=0.500      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   8/50 (16%)   45/50 (90%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |                                                        |6/47.72      8/45.09      45/48.07     40/41.09     | 
|POLY-3 PERCENT (g) |                                                        |12.6%        17.7%        93.6%        97.4%        | 
|TERMINAL (d)       |                                                        |3/39 (8%)    3/32 (9%)    37/39 (95%)  23/23 (100%) | 
|FIRST INCIDENCE    |                                                        |562          633          639          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P<0.001 **   P=0.284      P<0.001 **   P<0.001 **   | 
|POLY 3             |                                                        |P<0.001 **   P=0.343      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |                                                        |P<0.001 **   P=0.360      P<0.001 **   P<0.001 **   | 
|POLY 6             |                                                        |P<0.001 **   P=0.325      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|                                                        |P<0.001 **   P=0.406      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |                                                        |P<0.001 **   P=0.387      P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |12/50 (24%)  20/50 (40%)  27/50 (54%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |                                                        |12/48.16     20/44.35     27/48.13     19/37.43     | 
|POLY-3 PERCENT (g) |                                                        |24.9%        45.1%        56.1%        50.8%        | 
|TERMINAL (d)       |                                                        |9/39 (23%)   18/32 (56%)  22/39 (56%)  14/23 (61%)  | 
|FIRST INCIDENCE    |                                                        |338          688          516          382          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.002 **   P=0.016 *    P=0.004 **   P=0.002 **   | 
|POLY 3             |                                                        |P=0.008 **   P=0.032 *    P<0.001 **   P=0.011 *    | 
|POLY 1.5           |                                                        |P=0.019 *    P=0.042 *    P<0.001 **   P=0.022 *    | 
|POLY 6             |                                                        |P=0.004 **   P=0.022 *    P<0.001 **   P=0.005 **   | 
|LOGISTIC REGRESSION|                                                        |P=0.016 *    P=0.046 *    P=0.002 **   P=0.026 *    | 
|COCH-ARM / FISHERS |                                                        |P=0.127      P=0.066      P=0.002 **   P=0.097      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.90      0/44.06      2/47.00      2/36.08      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         4.3%         5.5%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/32 (0%)    2/39 (5%)    1/23 (4%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          729 (T)      352          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.036 *    (e)          P=0.238      P=0.177      | 
|POLY 3             |                                                        |P=0.042 *    (e)          P=0.238      P=0.184      | 
|POLY 1.5           |                                                        |P=0.048 *    (e)          P=0.237      P=0.199      | 
|POLY 6             |                                                        |P=0.038 *    (e)          P=0.239      P=0.172      | 
|LOGISTIC REGRESSION|                                                        |P=0.096      (e)          P=0.238      P=0.343      | 
|COCH-ARM / FISHERS |                                                        |P=0.072      (e)          P=0.247      P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.90      1/44.06      3/47.00      2/35.19      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.3%         6.4%         5.7%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    1/32 (3%)    3/39 (8%)    2/23 (9%)    | 
|FIRST INCIDENCE    |                                                        |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.068      P=0.461      P=0.121      P=0.132      | 
|POLY 3             |                                                        |P=0.084      P=0.488      P=0.119      P=0.180      | 
|POLY 1.5           |                                                        |P=0.099      P=0.493      P=0.119      P=0.195      | 
|POLY 6             |                                                        |P=0.074      P=0.481      P=0.120      P=0.167      | 
|LOGISTIC REGRESSION|                                                        |(e)          P=0.461      P=0.121      P=0.132      | 
|COCH-ARM / FISHERS |                                                        |P=0.159      P=0.500      P=0.121      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.90      0/44.06      0/47.00      2/35.29      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         0.0%         5.7%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/32 (0%)    0/39 (0%)    1/23 (4%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          ---          704          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.021 *    (e)          (e)          P=0.141      | 
|POLY 3             |                                                        |P=0.038 *    (e)          (e)          P=0.181      | 
|POLY 1.5           |                                                        |P=0.037 *    (e)          (e)          P=0.196      | 
|POLY 6             |                                                        |P=0.042 *    (e)          (e)          P=0.168      | 
|LOGISTIC REGRESSION|                                                        |P=0.024 *    (e)          (e)          P=0.158      | 
|COCH-ARM / FISHERS |                                                        |P=0.043 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    9/50 (18%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.19      2/46.03      1/45.28      0/30.48     |2/46.90      1/44.06      9/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     2.2%         4.3%         2.2%         0.0%        |4.3%         2.3%         19.2%        0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    2/42 (5%)    1/39 (3%)    0/14 (0%)   |2/39 (5%)    1/32 (3%)    9/39 (23%)   0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      730 (T)      ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.395N     P=0.535      P=0.756N     P=0.699N    |P=0.440      P=0.569N     P=0.026 *    P=0.361N     | 
|POLY 3             |     P=0.313N     P=0.499      P=0.756      P=0.580N    |P=0.363      P=0.522N     P=0.025 *    P=0.306N     | 
|POLY 1.5           |     P=0.269N     P=0.493      P=0.756      P=0.555N    |P=0.442      P=0.513N     P=0.025 *    P=0.285N     | 
|POLY 6             |     P=0.361N     P=0.506      P=0.757      P=0.604N    |P=0.297      P=0.533N     P=0.026 *    P=0.327N     | 
|LOGISTIC REGRESSION|     P=0.395N     P=0.535      P=0.756N     (e)         |P=0.440      P=0.569N     P=0.026 *    (e)          | 
|COCH-ARM / FISHERS |     P=0.209N     P=0.500      P=0.753N     P=0.500N    |P=0.500N     P=0.500N     P=0.026 *    P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      1/46.03      0/45.28      1/30.68     |2/47.24      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         3.3%        |4.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      ---          679         |659          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.287      P=0.520      (e)          P=0.371     |P=0.182N     P=0.276N     P=0.234N     P=0.346N     | 
|POLY 3             |     P=0.416      P=0.499      (e)          P=0.421     |P=0.137N     P=0.253N     P=0.238N     P=0.308N     | 
|POLY 1.5           |     P=0.405      P=0.496      (e)          P=0.445     |P=0.139N     P=0.246N     P=0.239N     P=0.286N     | 
|POLY 6             |     P=0.435      P=0.504      (e)          P=0.398     |P=0.136N     P=0.262N     P=0.238N     P=0.331N     | 
|LOGISTIC REGRESSION|     P=0.377      P=0.520      (e)          P=0.445     |P=0.145N     P=0.224N     P=0.231N     P=0.258N     | 
|COCH-ARM / FISHERS |     P=0.455      P=0.500      (e)          P=0.500     |P=0.152N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/42 (5%)    0/44 (0%)    0/34 (0%)    1/41 (2%)   |1/43 (2%)    1/39 (3%)    0/37 (0%)    0/34 (0%)    | 
|POLY-3 RATE (b)    |     2/39.31      0/42.80      0/31.49      1/24.92     |1/40.62      1/35.01      0/35.07      0/23.45      | 
|POLY-3 PERCENT (g) |     5.1%         0.0%         0.0%         4.0%        |2.5%         2.9%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/40 (0%)    0/27 (0%)    1/12 (8%)   |0/34 (0%)    1/29 (3%)    0/29 (0%)    0/17 (0%)    | 
|FIRST INCIDENCE    |     528          ---          ---          730 (T)     |704          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.611      P=0.218N     P=0.262N     P=0.721     |P=0.272N     P=0.719      P=0.491N     P=0.596N     | 
|POLY 3             |     P=0.564N     P=0.218N     P=0.287N     P=0.650N    |P=0.252N     P=0.727      P=0.529N     P=0.605N     | 
|POLY 1.5           |     P=0.552N     P=0.222N     P=0.289N     P=0.608N    |P=0.241N     P=0.731      P=0.529N     P=0.589N     | 
|POLY 6             |     P=0.571N     P=0.213N     P=0.285N     P=0.688N    |P=0.261N     P=0.723      P=0.530N     P=0.617N     | 
|LOGISTIC REGRESSION|     P=0.514N     P=0.328N     P=0.231N     P=0.567N    |P=0.276N     P=0.732      P=0.533N     P=0.603N     | 
|COCH-ARM / FISHERS |     P=0.539N     P=0.236N     P=0.302N     P=0.509N    |P=0.242N     P=0.728      P=0.537N     P=0.558N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    2/46 (4%)    3/47 (6%)    2/47 (4%)   |0/48 (0%)    0/49 (0%)    1/48 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/45.19      2/42.03      3/43.10      2/28.82     |0/44.90      0/43.87      1/45.06      0/34.75      | 
|POLY-3 PERCENT (g) |     6.6%         4.8%         7.0%         6.9%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    2/38 (5%)    2/37 (5%)    2/14 (14%)  |0/37 (0%)    0/32 (0%)    1/38 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      515          730 (T)     |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.317      P=0.488N     P=0.659      P=0.447     |P=0.614      (e)          P=0.505      (e)          | 
|POLY 3             |     P=0.490      P=0.533N     P=0.640      P=0.657     |P=0.530      (e)          P=0.501      (e)          | 
|POLY 1.5           |     P=0.537      P=0.540N     P=0.638      P=0.641N    |P=0.558      (e)          P=0.500      (e)          | 
|POLY 6             |     P=0.451      P=0.524N     P=0.646      P=0.602     |P=0.513      (e)          P=0.503      (e)          | 
|LOGISTIC REGRESSION|     P=0.510      P=0.488N     P=0.651      P=0.447     |(e)          (e)          P=0.505      (e)          | 
|COCH-ARM / FISHERS |     P=0.489N     P=0.530N     P=0.641      P=0.520N    |P=0.658      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/46 (0%)    0/47 (0%)    0/47 (0%)   |10/48 (21%)  8/49 (16%)   6/48 (13%)   2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.19      0/42.03      0/42.45      0/28.82     |10/45.09     8/43.87      6/45.06      2/35.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |22.2%        18.2%        13.3%        5.7%         | 
|TERMINAL (d)       |     0/37 (0%)    0/38 (0%)    0/37 (0%)    0/14 (0%)   |9/37 (24%)   8/32 (25%)   6/38 (16%)   1/23 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |677          729 (T)      729 (T)      547          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.038N*    P=0.533N     P=0.188N     P=0.086N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.026N*    P=0.422N     P=0.205N     P=0.040N*    | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.021N*    P=0.402N     P=0.208N     P=0.029N*    | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.031N*    P=0.451N     P=0.200N     P=0.052N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.030N*    P=0.493N     P=0.186N     P=0.041N*    | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.009N**   P=0.379N     P=0.206N     P=0.012N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/49 (22%)  13/50 (26%)  11/50 (22%)  13/50 (26%) |                                                    | 
|POLY-3 RATE (b)    |     11/46.15     13/46.19     11/45.45     13/35.20    |                                                    | 
|POLY-3 PERCENT (g) |     23.8%        28.1%        24.2%        36.9%       |                                                    | 
|TERMINAL (d)       |     9/37 (24%)   12/42 (29%)  10/39 (26%)  3/14 (21%)  |                                                    | 
|FIRST INCIDENCE    |     528          689          685          410         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.007 **   P=0.534      P=0.551N     P=0.017 *   |                                                    | 
|POLY 3             |     P=0.183      P=0.408      P=0.580      P=0.152     |                                                    | 
|POLY 1.5           |     P=0.243      P=0.398      P=0.588      P=0.213     |                                                    | 
|POLY 6             |     P=0.142      P=0.423      P=0.577      P=0.108     |                                                    | 
|LOGISTIC REGRESSION|     P=0.241      P=0.417      P=0.592N     P=0.318     |                                                    | 
|COCH-ARM / FISHERS |     P=0.453      P=0.430      P=0.574N     P=0.430     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/49 (18%)   3/50 (6%)    8/50 (16%)   2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     9/45.26      3/46.19      8/45.87      2/30.49     |                                                    | 
|POLY-3 PERCENT (g) |     19.9%        6.5%         17.4%        6.6%        |                                                    | 
|TERMINAL (d)       |     8/37 (22%)   2/42 (5%)    5/39 (13%)   1/14 (7%)   |                                                    | 
|FIRST INCIDENCE    |     714          689          610          728         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.514N     P=0.042N*    P=0.468N     P=0.341N    |                                                    | 
|POLY 3             |     P=0.290N     P=0.054N     P=0.488N     P=0.107N    |                                                    | 
|POLY 1.5           |     P=0.201N     P=0.059N     P=0.491N     P=0.068N    |                                                    | 
|POLY 6             |     P=0.390N     P=0.049N*    P=0.476N     P=0.161N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.305N     P=0.050N     P=0.496N     P=0.232N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.085N     P=0.056N     P=0.482N     P=0.023N*   |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland: Duct                                                                                                            | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/49 (35%)  11/50 (22%)  22/50 (44%)  16/50 (32%) |                                                    | 
|POLY-3 RATE (b)    |     17/46.34     11/46.26     22/45.65     16/34.51    |                                                    | 
|POLY-3 PERCENT (g) |     36.7%        23.8%        48.2%        46.4%       |                                                    | 
|TERMINAL (d)       |     14/37 (38%)  9/42 (21%)   21/39 (54%)  6/14 (43%)  |                                                    | 
|FIRST INCIDENCE    |     528          689          626          410         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.080N     P=0.255      P=0.013 *   |                                                    | 
|POLY 3             |     P=0.040 *    P=0.129N     P=0.181      P=0.260     |                                                    | 
|POLY 1.5           |     P=0.085      P=0.136N     P=0.192      P=0.378     |                                                    | 
|POLY 6             |     P=0.019 *    P=0.118N     P=0.174      P=0.170     |                                                    | 
|LOGISTIC REGRESSION|     P=0.045 *    P=0.125N     P=0.204      P=0.333     |                                                    | 
|COCH-ARM / FISHERS |     P=0.324      P=0.119N     P=0.229      P=0.472N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  31/50 (62%)  29/50 (58%)  22/50 (44%) |                                                    | 
|POLY-3 RATE (b)    |     36/48.70     31/46.80     29/46.88     22/35.91    |                                                    | 
|POLY-3 PERCENT (g) |     73.9%        66.2%        61.9%        61.3%       |                                                    | 
|TERMINAL (d)       |     27/38 (71%)  29/42 (69%)  26/39 (67%)  10/14 (71%) |                                                    | 
|FIRST INCIDENCE    |     528          535          515          239         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032 *    P=0.096N     P=0.113N     P=0.073     |                                                    | 
|POLY 3             |     P=0.126N     P=0.274N     P=0.144N     P=0.151N    |                                                    | 
|POLY 1.5           |     P=0.050N     P=0.275N     P=0.131N     P=0.057N    |                                                    | 
|POLY 6             |     P=0.257N     P=0.280N     P=0.163N     P=0.330N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.125N     P=0.231N     P=0.122N     P=0.119N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.003N**   P=0.198N     P=0.104N     P=0.004N**  |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.69      2/46.19      0/45.28      0/30.48     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         4.3%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/38 (3%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |                                                    | 
|FIRST INCIDENCE    |     582          689          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.133N     P=0.672N     P=0.244N     P=0.422N    |                                                    | 
|POLY 3             |     P=0.096N     P=0.690      P=0.244N     P=0.342N    |                                                    | 
|POLY 1.5           |     P=0.084N     P=0.685      P=0.243N     P=0.306N    |                                                    | 
|POLY 6             |     P=0.108N     P=0.691N     P=0.245N     P=0.382N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.069N     P=0.687N     P=0.205N     P=0.240N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.072N     P=0.691N     P=0.247N     P=0.247N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  34/50 (68%)  36/50 (72%)  23/50 (46%) |36/50 (72%)  32/50 (64%)  32/49 (65%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |     35/48.55     34/47.28     36/47.72     23/35.14    |36/48.16     32/47.19     32/46.47     15/37.73     | 
|POLY-3 PERCENT (g) |     72.1%        71.9%        75.5%        65.5%       |74.8%        67.8%        68.9%        39.8%        | 
|TERMINAL (d)       |     29/38 (76%)  32/42 (76%)  30/39 (77%)  12/14 (86%) |31/39 (80%)  23/32 (72%)  29/39 (74%)  10/23 (44%)  | 
|FIRST INCIDENCE    |     528          518          497          274         |562          424          639          113          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.264N     P=0.543      P=0.015 *   |P=0.020N*    P=0.417      P=0.255N     P=0.053N     | 
|POLY 3             |     P=0.362N     P=0.583N     P=0.443      P=0.337N    |P<0.001N**   P=0.296N     P=0.339N     P<0.001N**   | 
|POLY 1.5           |     P=0.152N     P=0.582      P=0.451      P=0.152N    |P<0.001N**   P=0.278N     P=0.334N     P<0.001N**   | 
|POLY 6             |     P=0.483      P=0.575N     P=0.442      P=0.582N    |P=0.003N**   P=0.325N     P=0.343N     P=0.002N**   | 
|LOGISTIC REGRESSION|     P=0.285N     P=0.561N     P=0.454      P=0.338N    |P<0.001N**   P=0.338N     P=0.288N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.007N**   P=0.500N     P=0.500      P=0.013N*   |P<0.001N**   P=0.260N     P=0.308N     P<0.001N**   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue                                                                                                        | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      0/46.03      0/45.28      0/30.48     |1/46.90      2/44.39      1/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.1%         4.5%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |1/39 (3%)    1/32 (3%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      640          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.282N     P=0.449      P=0.762      P=0.605N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.267N     P=0.481      P=0.760N     P=0.556N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.247N     P=0.489      P=0.760      P=0.540N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.289N     P=0.471      P=0.758N     P=0.571N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.243N     P=0.501      P=0.762      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.209N     P=0.500      P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue                                                                                                        | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      0/46.03      0/45.28      0/30.48     |0/46.90      2/44.39      1/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.5%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    1/32 (3%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          640          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.459N     P=0.214      P=0.500      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.454N     P=0.225      P=0.500      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.425N     P=0.230      P=0.500      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.487N     P=0.219      P=0.502      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.404N     P=0.246      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.372N     P=0.247      P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  7/50 (14%)   16/50 (32%)  12/50 (24%) |17/50 (34%)  23/50 (46%)  24/50 (48%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     17/49.10     7/46.19      16/47.69     12/33.65    |17/47.93     23/46.93     24/48.34     21/39.98     | 
|POLY-3 PERCENT (g) |     34.6%        15.2%        33.6%        35.7%       |35.5%        49.0%        49.7%        52.5%        | 
|TERMINAL (d)       |     8/38 (21%)   6/42 (14%)   8/39 (21%)   3/14 (21%)  |14/39 (36%)  13/32 (41%)  16/39 (41%)  9/23 (39%)   | 
|FIRST INCIDENCE    |     464          689          515          502         |562          468          639          113          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.027 *    P=0.018N*    P=0.501N     P=0.198     |P=0.030 *    P=0.063      P=0.141      P=0.015 *    | 
|POLY 3             |     P=0.204      P=0.024N*    P=0.541N     P=0.553     |P=0.104      P=0.128      P=0.114      P=0.080      | 
|POLY 1.5           |     P=0.294      P=0.023N*    P=0.534N     P=0.484N    |P=0.144      P=0.137      P=0.108      P=0.115      | 
|POLY 6             |     P=0.146      P=0.025N*    P=0.539N     P=0.422     |P=0.086      P=0.120      P=0.126      P=0.062      | 
|LOGISTIC REGRESSION|     P=0.461      P=0.016N*    P=0.449N     P=0.342N    |P=0.207      P=0.151      P=0.110      P=0.159      | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.017N*    P=0.500N     P=0.189N    |P=0.344      P=0.154      P=0.111      P=0.268      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |18/50 (36%)  16/50 (32%)  17/50 (34%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     2/46.19      0/46.03      0/45.28      0/30.48     |18/46.98     16/44.37     17/47.00     10/35.68     | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |38.3%        36.1%        36.2%        28.0%        | 
|TERMINAL (d)       |     2/38 (5%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |17/39 (44%)  14/32 (44%)  17/39 (44%)  9/23 (39%)   | 
|FIRST INCIDENCE    |     730 (T)      ---          ---          ---         |708          653          729 (T)      582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.226N     P=0.217N     P=0.233N     P=0.475N    |P=0.391N     P=0.473      P=0.497N     P=0.511N     | 
|POLY 3             |     P=0.158N     P=0.238N     P=0.242N     P=0.340N    |P=0.218N     P=0.498N     P=0.499N     P=0.230N     | 
|POLY 1.5           |     P=0.145N     P=0.242N     P=0.241N     P=0.305N    |P=0.163N     P=0.464N     P=0.505N     P=0.163N     | 
|POLY 6             |     P=0.170N     P=0.233N     P=0.241N     P=0.377N    |P=0.268N     P=0.541N     P=0.491N     P=0.303N     | 
|LOGISTIC REGRESSION|     P=0.226N     (e)          (e)          (e)         |P=0.321N     P=0.537      P=0.451N     P=0.391N     | 
|COCH-ARM / FISHERS |     P=0.152N     P=0.247N     P=0.247N     P=0.247N    |P=0.056N     P=0.417N     P=0.500N     P=0.059N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis Diffuse                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    6/50 (12%)  |1/50 (2%)    0/50 (0%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/46.19      0/46.03      3/46.21      6/33.07     |1/46.98      0/44.06      2/47.04      3/37.03      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.5%         18.2%       |2.1%         0.0%         4.3%         8.1%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    1/39 (3%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          515          239         |708          ---          721          185          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.123      P=0.003 **  |P=0.041 *    P=0.537N     P=0.511      P=0.208      | 
|POLY 3             |     P<0.001 **   (e)          P=0.119      P=0.004 **  |P=0.054      P=0.513N     P=0.500      P=0.227      | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.118      P=0.007 **  |P=0.060      P=0.507N     P=0.499      P=0.249      | 
|POLY 6             |     P<0.001 **   (e)          P=0.121      P=0.003 **  |P=0.052      P=0.520N     P=0.503      P=0.206      | 
|LOGISTIC REGRESSION|     P=0.004 **   (e)          P=0.146      P=0.034 *   |P=0.207      P=0.506N     P=0.501      P=0.596      | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.121      P=0.013 *   |P=0.081      P=0.500N     P=0.500      P=0.309      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    4/50 (8%)    6/50 (12%)  |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.27      3/46.10      4/46.56      6/31.93     |1/46.90      1/44.34      0/47.00      1/35.52      | 
|POLY-3 PERCENT (g) |     4.3%         6.5%         8.6%         18.8%       |2.1%         2.3%         0.0%         2.8%         | 
|TERMINAL (d)       |     1/38 (3%)    2/42 (5%)    1/39 (3%)    3/14 (21%)  |1/39 (3%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     712          714          512          477         |729 (T)      653          ---          640          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   P=0.533      P=0.335      P=0.012 *   |P=0.621      P=0.723      P=0.500N     P=0.663      | 
|POLY 3             |     P=0.031 *    P=0.498      P=0.340      P=0.048 *   |P=0.592N     P=0.748      P=0.500N     P=0.695      | 
|POLY 1.5           |     P=0.039 *    P=0.491      P=0.336      P=0.067     |P=0.591N     P=0.753      P=0.500N     P=0.714      | 
|POLY 6             |     P=0.026 *    P=0.508      P=0.347      P=0.033 *   |P=0.596N     P=0.742      P=0.498N     P=0.676      | 
|LOGISTIC REGRESSION|     P=0.064      P=0.506      P=0.384      P=0.069     |P=0.589N     P=0.758N     (e)          P=0.740      | 
|COCH-ARM / FISHERS |     P=0.081      P=0.500      P=0.339      P=0.134     |P=0.592N     P=0.753N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.19      3/46.26      1/45.82      2/30.56     |1/47.16      2/44.50      2/47.04      1/35.19      | 
|POLY-3 PERCENT (g) |     2.2%         6.5%         2.2%         6.5%        |2.1%         4.5%         4.3%         2.8%         | 
|TERMINAL (d)       |     1/38 (3%)    1/42 (2%)    0/39 (0%)    1/14 (7%)   |0/39 (0%)    0/32 (0%)    1/39 (3%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     730 (T)      689          563          709         |659          653          721          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.294      P=0.336      P=0.758      P=0.206     |P=0.553      P=0.451      P=0.500      P=0.650      | 
|POLY 3             |     P=0.469      P=0.306      P=0.759      P=0.363     |P=0.554      P=0.480      P=0.499      P=0.691      | 
|POLY 1.5           |     P=0.489      P=0.299      P=0.758      P=0.405     |P=0.585      P=0.488      P=0.498      P=0.712      | 
|POLY 6             |     P=0.460      P=0.315      P=0.760N     P=0.322     |P=0.530      P=0.470      P=0.500      P=0.669      | 
|LOGISTIC REGRESSION|     P=0.496      P=0.301      P=0.735N     P=0.271     |P=0.578N     P=0.533      P=0.501      P=0.726      | 
|COCH-ARM / FISHERS |     P=0.586      P=0.309      P=0.753N     P=0.500     |P=0.527N     P=0.500      P=0.500      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer Focal                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      2/46.26      1/45.96      0/30.48     |1/47.16      1/44.22      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         2.2%         0.0%        |2.1%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |0/39 (0%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          689          497          ---         |659          688          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.500N     P=0.253      P=0.500      (e)         |P=0.254N     P=0.728      P=0.504N     P=0.585N     | 
|POLY 3             |     P=0.509N     P=0.238      P=0.499      (e)         |P=0.217N     P=0.746      P=0.501N     P=0.557N     | 
|POLY 1.5           |     P=0.453N     P=0.234      P=0.498      (e)         |P=0.212N     P=0.752      P=0.501N     P=0.541N     | 
|POLY 6             |     P=0.566N     P=0.243      P=0.501      (e)         |P=0.225N     P=0.738      P=0.500N     P=0.573N     | 
|LOGISTIC REGRESSION|     P=0.318N     P=0.236      P=0.664      (e)         |P=0.196N     P=0.747N     P=0.487N     P=0.502N     | 
|COCH-ARM / FISHERS |     P=0.372N     P=0.247      P=0.500      (e)         |P=0.212N     P=0.753N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    8/50 (16%)   9/50 (18%)  |2/50 (4%)    2/50 (4%)    5/50 (10%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/46.27      4/46.26      8/47.46      9/32.92     |2/46.98      2/44.50      5/47.17      7/37.18      | 
|POLY-3 PERCENT (g) |     4.3%         8.7%         16.9%        27.3%       |4.3%         4.5%         10.6%        18.8%        | 
|TERMINAL (d)       |     1/38 (3%)    2/42 (5%)    3/39 (8%)    4/14 (29%)  |1/39 (3%)    0/32 (0%)    3/39 (8%)    3/23 (13%)   | 
|FIRST INCIDENCE    |     712          689          497          337         |708          653          695          382          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.374      P=0.055      P<0.001 **  |P=0.004 **   P=0.631      P=0.230      P=0.022 *    | 
|POLY 3             |     P=0.002 **   P=0.337      P=0.050      P=0.004 **  |P=0.009 **   P=0.674      P=0.218      P=0.036 *    | 
|POLY 1.5           |     P=0.003 **   P=0.329      P=0.047 *    P=0.008 **  |P=0.011 *    P=0.682      P=0.216      P=0.045 *    | 
|POLY 6             |     P<0.001 **   P=0.348      P=0.053      P=0.002 **  |P=0.008 **   P=0.665      P=0.221      P=0.030 *    | 
|LOGISTIC REGRESSION|     P=0.013 *    P=0.333      P=0.062      P=0.014 *   |P=0.019 *    P=0.690N     P=0.218      P=0.072      | 
|COCH-ARM / FISHERS |     P=0.013 *    P=0.339      P=0.046 *    P=0.026 *   |P=0.022 *    P=0.691N     P=0.218      P=0.080      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      2/46.19      0/45.28      0/30.48     |1/46.90      0/44.06      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    1/42 (2%)    0/39 (0%)    0/14 (0%)   |1/39 (3%)    0/32 (0%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          689          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407N     P=0.259      (e)          (e)         |P=0.390N     P=0.539N     P=0.500N     P=0.605N     | 
|POLY 3             |     P=0.339N     P=0.237      (e)          (e)         |P=0.313N     P=0.512N     P=0.500N     P=0.556N     | 
|POLY 1.5           |     P=0.310N     P=0.233      (e)          (e)         |P=0.315N     P=0.507N     P=0.500N     P=0.540N     | 
|POLY 6             |     P=0.368N     P=0.243      (e)          (e)         |P=0.316N     P=0.519N     P=0.498N     P=0.571N     | 
|LOGISTIC REGRESSION|     P=0.337N     P=0.235      (e)          (e)         |P=0.390N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.284N     P=0.247      (e)          (e)         |P=0.344N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.19      0/46.03      1/45.45      0/30.48     |2/46.90      0/44.06      1/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |4.3%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/42 (0%)    0/39 (0%)    0/14 (0%)   |2/39 (5%)    0/32 (0%)    1/39 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          685          ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.581      (e)          P=0.505      (e)         |P=0.313N     P=0.283N     P=0.500N     P=0.361N     | 
|POLY 3             |     P=0.495      (e)          P=0.497      (e)         |P=0.272N     P=0.251N     P=0.499N     P=0.306N     | 
|POLY 1.5           |     P=0.527      (e)          P=0.497      (e)         |P=0.261N     P=0.246N     P=0.501N     P=0.285N     | 
|POLY 6             |     P=0.462      (e)          P=0.498      (e)         |P=0.284N     P=0.259N     P=0.497N     P=0.327N     | 
|LOGISTIC REGRESSION|     P=0.648      (e)          P=0.508      (e)         |P=0.313N     (e)          P=0.500N     (e)          | 
|COCH-ARM / FISHERS |     P=0.656      (e)          P=0.500      (e)         |P=0.242N     P=0.247N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Glands                                                                                                       | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    7/50 (14%)   11/50 (22%)  4/50 (8%)   |11/50 (22%)  11/50 (22%)  6/50 (12%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/46.19      7/46.35      11/45.34     4/30.48     |11/47.18     11/44.08     6/47.00      6/36.05      | 
|POLY-3 PERCENT (g) |     4.3%         15.1%        24.3%        13.1%       |23.3%        25.0%        12.8%        16.6%        | 
|TERMINAL (d)       |     2/38 (5%)    5/42 (12%)   10/39 (26%)  4/14 (29%)  |10/39 (26%)  10/32 (31%)  6/39 (15%)   5/23 (22%)   | 
|FIRST INCIDENCE    |     730 (T)      689          714          730 (T)     |653          724          729 (T)      382          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    P=0.109      P=0.010 *    P=0.034 *   |P=0.242N     P=0.391      P=0.143N     P=0.518N     | 
|POLY 3             |     P=0.087      P=0.080      P=0.006 **   P=0.176     |P=0.130N     P=0.525      P=0.143N     P=0.321N     | 
|POLY 1.5           |     P=0.157      P=0.075      P=0.006 **   P=0.220     |P=0.110N     P=0.554      P=0.145N     P=0.260N     | 
|POLY 6             |     P=0.044 *    P=0.086      P=0.006 **   P=0.137     |P=0.148N     P=0.485      P=0.141N     P=0.385N     | 
|LOGISTIC REGRESSION|     P=0.055      P=0.080      P=0.008 **   P=0.034 *   |P=0.171N     P=0.441      P=0.133N     P=0.307N     | 
|COCH-ARM / FISHERS |     P=0.417      P=0.080      P=0.007 **   P=0.339     |P=0.062N     P=0.595N     P=0.143N     P=0.143N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.19      1/46.03      2/45.45      0/30.48     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         4.4%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/38 (5%)    1/42 (2%)    1/39 (3%)    0/14 (0%)   |                                                    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      685          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.439N     P=0.465N     P=0.684N     P=0.475N    |                                                    | 
|POLY 3             |     P=0.366N     P=0.501N     P=0.688      P=0.340N    |                                                    | 
|POLY 1.5           |     P=0.306N     P=0.507N     P=0.688      P=0.305N    |                                                    | 
|POLY 6             |     P=0.431N     P=0.494N     P=0.691      P=0.377N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.353N     P=0.465N     P=0.689      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.222N     P=0.500N     P=0.691N     P=0.247N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.69      1/46.03      3/45.42      1/30.54     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         6.6%         3.3%        |                                                    | 
|TERMINAL (d)       |     1/38 (3%)    1/42 (2%)    1/39 (3%)    0/14 (0%)   |                                                    | 
|FIRST INCIDENCE    |     582          730 (T)      709          716         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.393      P=0.482N     P=0.495      P=0.708     |                                                    | 
|POLY 3             |     P=0.475      P=0.505N     P=0.488      P=0.640N    |                                                    | 
|POLY 1.5           |     P=0.533      P=0.509N     P=0.490      P=0.597N    |                                                    | 
|POLY 6             |     P=0.421      P=0.500N     P=0.488      P=0.681N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.577      P=0.489N     P=0.508      P=0.589N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.512N     P=0.500N     P=0.500      P=0.500N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/47 (15%)   4/47 (9%)    7/44 (16%)   4/46 (9%)   |6/50 (12%)   11/50 (22%)  4/47 (9%)    10/50 (20%)  | 
|POLY-3 RATE (b)    |     7/44.49      4/44.20      7/41.42      4/29.55     |6/48.59      11/46.80     4/44.83      10/39.02     | 
|POLY-3 PERCENT (g) |     15.7%        9.1%         16.9%        13.5%       |12.4%        23.5%        8.9%         25.6%        | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    1/34 (3%)    0/13 (0%)   |0/39 (0%)    1/32 (3%)    1/37 (3%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     582          535          497          502         |562          468          639          386          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.363      P=0.247N     P=0.588      P=0.583     |P=0.171      P=0.110      P=0.370N     P=0.067      | 
|POLY 3             |     P=0.459      P=0.265N     P=0.557      P=0.528N    |P=0.249      P=0.123      P=0.421N     P=0.095      | 
|POLY 1.5           |     P=0.539      P=0.274N     P=0.554      P=0.449N    |P=0.278      P=0.131      P=0.419N     P=0.118      | 
|POLY 6             |     P=0.392      P=0.254N     P=0.564      P=0.603N    |P=0.227      P=0.116      P=0.424N     P=0.077      | 
|LOGISTIC REGRESSION|     P=0.274N     P=0.227N     P=0.589N     P=0.279N    |P=0.495N     P=0.220      P=0.383N     P=0.323      | 
|COCH-ARM / FISHERS |     P=0.367N     P=0.261N     P=0.561      P=0.274N    |P=0.387      P=0.143      P=0.410N     P=0.207      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Ectopic Parathyroid Gland                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/47 (0%)    0/44 (0%)    0/46 (0%)   |1/50 (2%)    2/50 (4%)    0/47 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.19      0/43.10      0/39.34      0/27.71     |1/46.90      2/45.34      0/44.31      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.1%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/34 (0%)    0/13 (0%)   |1/39 (3%)    0/32 (0%)    0/37 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      468          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.176N     P=0.472      P=0.511N     P=0.605N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.163N     P=0.488      P=0.511N     P=0.556N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.154N     P=0.493      P=0.513N     P=0.540N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.172N     P=0.481      P=0.509N     P=0.571N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.059N     P=0.590      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.144N     P=0.500      P=0.515N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/47 (0%)    0/44 (0%)    0/46 (0%)   |1/50 (2%)    0/50 (0%)    2/47 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.19      0/43.10      0/39.34      0/27.71     |1/46.90      0/44.06      2/44.31      0/35.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.1%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/34 (0%)    0/13 (0%)   |1/39 (3%)    0/32 (0%)    2/37 (5%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.632N     P=0.539N     P=0.482      P=0.605N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.617N     P=0.512N     P=0.480      P=0.556N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.585N     P=0.507N     P=0.478      P=0.540N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.611      P=0.519N     P=0.484      P=0.571N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.632N     (e)          P=0.482      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.521N     P=0.500N     P=0.477      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus: Thymocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    1/47 (2%)    0/44 (0%)    3/46 (7%)   |1/50 (2%)    0/50 (0%)    0/47 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.19      1/44.10      0/39.34      3/29.29     |1/47.80      0/44.06      0/44.31      1/36.19      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         10.2%       |2.1%         0.0%         0.0%         2.8%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/34 (0%)    0/13 (0%)   |0/39 (0%)    0/32 (0%)    0/37 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |     ---          4            ---          114         |338          ---          ---          135          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    P=0.496      (e)          P=0.059     |P=0.534      P=0.500N     P=0.504N     P=0.749      | 
|POLY 3             |     P=0.041 *    P=0.504      (e)          P=0.065     |P=0.517      P=0.516N     P=0.515N     P=0.694      | 
|POLY 1.5           |     P=0.039 *    P=0.501      (e)          P=0.077     |P=0.518      P=0.510N     P=0.515N     P=0.715      | 
|POLY 6             |     P=0.046 *    P=0.509      (e)          P=0.054     |P=0.530      P=0.523N     P=0.513N     P=0.674      | 
|LOGISTIC REGRESSION|     P=0.221      (e)          (e)          P=0.279     |P=0.119N     (e)          P=0.301N     P=0.147N     | 
|COCH-ARM / FISHERS |     P=0.050      P=0.500      (e)          P=0.117     |P=0.543      P=0.500N     P=0.515N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    5/50 (10%)   1/50 (2%)   |6/50 (12%)   4/50 (8%)    3/49 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.53      3/46.03      5/45.65      1/30.48     |6/46.90      4/44.06      3/46.06      1/35.19      | 
|POLY-3 PERCENT (g) |     6.5%         6.5%         11.0%        3.3%        |12.8%        9.1%         6.5%         2.8%         | 
|TERMINAL (d)       |     2/38 (5%)    3/42 (7%)    4/39 (10%)   1/14 (7%)   |6/39 (15%)   4/32 (13%)   3/39 (8%)    1/23 (4%)    | 
|FIRST INCIDENCE    |     636          730 (T)      626          730 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.481      P=0.619N     P=0.366      P=0.644N    |P=0.098N     P=0.498N     P=0.241N     P=0.183N     | 
|POLY 3             |     P=0.551N     P=0.657      P=0.346      P=0.467N    |P=0.075N     P=0.409N     P=0.251N     P=0.119N     | 
|POLY 1.5           |     P=0.454N     P=0.651      P=0.347      P=0.413N    |P=0.065N     P=0.393N     P=0.254N     P=0.097N     | 
|POLY 6             |     P=0.510      P=0.660N     P=0.348      P=0.523N    |P=0.085N     P=0.430N     P=0.247N     P=0.142N     | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.658      P=0.353      P=0.487N    |P=0.098N     P=0.498N     P=0.241N     P=0.183N     | 
|COCH-ARM / FISHERS |     P=0.283N     P=0.661N     P=0.357      P=0.309N    |P=0.042N*    P=0.370N     P=0.254N     P=0.056N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/9 (100%)   5/5 (100%)   3/4 (75%)    2/3 (67%)   |0/0 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)     | 
|POLY-3 RATE (b)    |     9/9.00       5/5.00       3/4.00       2/2.52      |0/0.00       0/0.00       1/1.00       0/0.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       75.0%        79.3%       |0.0%         0.0%         100.0%       0.0%         | 
|TERMINAL (d)       |     8/8 (100%)   5/5 (100%)   3/4 (75%)    1/1 (100%)  |0/0 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)     | 
|FIRST INCIDENCE    |     714          730 (T)      730 (T)      716         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.611      (e)          P=0.171N     P=0.554     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.115N     (e)          P=0.329N     P=0.668N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.086N     (e)          P=0.329N     P=0.424N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.197N     (e)          P=0.329N     P=0.994N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.484N     (e)          P=0.171N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.065N     (e)          P=0.308N     P=0.250N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 48      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/46.98      2/44.06      3/47.31      1/35.52      | 
|POLY-3 PERCENT (g) |                                                        |2.1%         4.5%         6.3%         2.8%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    2/32 (6%)    2/39 (5%)    0/23 (0%)    | 
|FIRST INCIDENCE    |                                                        |708          729 (T)      646          640          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.491      P=0.433      P=0.312      P=0.667      | 
|POLY 3             |                                                        |P=0.482      P=0.478      P=0.308      P=0.694      | 
|POLY 1.5           |                                                        |P=0.520      P=0.487      P=0.306      P=0.714      | 
|POLY 6             |                                                        |P=0.455      P=0.466      P=0.312      P=0.675      | 
|LOGISTIC REGRESSION|                                                        |P=0.573      P=0.459      P=0.306      P=0.755      | 
|COCH-ARM / FISHERS |                                                        |P=0.561N     P=0.500      P=0.309      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |1/47.00      2/44.24      0/47.00      0/35.19      | 
|POLY-3 PERCENT (g) |                                                        |2.1%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    1/32 (3%)    0/39 (0%)    0/23 (0%)    | 
|FIRST INCIDENCE    |                                                        |704          683          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.181N     P=0.439      P=0.491N     P=0.588N     | 
|POLY 3             |                                                        |P=0.158N     P=0.479      P=0.500N     P=0.557N     | 
|POLY 1.5           |                                                        |P=0.151N     P=0.488      P=0.501N     P=0.540N     | 
|POLY 6             |                                                        |P=0.167N     P=0.468      P=0.499N     P=0.572N     | 
|LOGISTIC REGRESSION|                                                        |P=0.158N     P=0.493      P=0.500N     P=0.554N     | 
|COCH-ARM / FISHERS |                                                        |P=0.141N     P=0.500      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/31/00                           EXPERIMENT: 50215 TEST: 03                                            Page 49      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   ACRYLONITRILE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG       2.5         10 MG/KG     20 MG/KG    |0 MG/KG       2.5         10 MG/KG     20 MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |40/50 (80%)  41/50 (82%)  29/50 (58%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |                                                        |40/47.59     41/47.30     29/47.36     19/36.27     | 
|POLY-3 PERCENT (g) |                                                        |84.1%        86.7%        61.2%        52.4%        | 
|TERMINAL (d)       |                                                        |36/39 (92%)  30/32 (94%)  27/39 (69%)  15/23 (65%)  | 
|FIRST INCIDENCE    |                                                        |653          468          645          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.003N**   P=0.046 *    P=0.009N**   P=0.099N     | 
|POLY 3             |                                                        |P<0.001N**   P=0.470      P=0.008N**   P<0.001N**   | 
|POLY 1.5           |                                                        |P<0.001N**   P=0.477      P=0.011N*    P<0.001N**   | 
|POLY 6             |                                                        |P<0.001N**   P=0.473      P=0.006N**   P=0.002N**   | 
|LOGISTIC REGRESSION|                                                        |P<0.001N**   P=0.254      P=0.006N**   P=0.014N*    | 
|COCH-ARM / FISHERS |                                                        |P<0.001N**   P=0.500      P=0.015N*    P<0.001N**   | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).