TDMS Study 55301-05 Pathology Tables
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 Facility: TSI Mason Research Chemical CAS #: 110-86-1 Lock Date: 12/15/94 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 3| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 7| 2| 4| 2| 9| 2| 8| 2| 2| 2| 9| 2| 2| 2| 9| 2| 2| 2| 2| 2| 3| 8| | 9| 9| 2| 3| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Pancreas | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X | Congestion | 2 1 2| Developmental Malformation | | Eosinophilic Focus | X X X X X X X X | Fibrosis | 1| Hepatodiaphragmatic Nodule | X X X X X| Inflammation, Chronic Active | 1 1 2 1 1 3 | Mitotic Alteration | 1 | Mixed Cell Focus | X | Necrosis | 2 1 1 1 | Pigmentation | 2 1 3 | Tension Lipidosis | X X X| Vacuolization Cytoplasmic | 4 2 2 1 1 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1| Centrilobular, Degeneration | | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 2 2 2 | __________________________________________________________________________| Oral Mucosa | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +| Atrophy | 2 1 2 1 2 1 1 1 1 1 1 1 1| Cytoplasmic Alteration | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Acute | | Inflammation, Chronic Active | 4 | Ulcer | 3 | Epithelium, Hyperplasia, Squamous | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 3| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 7| 2| 4| 2| 9| 2| 8| 2| 2| 2| 9| 2| 2| 2| 9| 2| 2| 2| 2| 2| 3| 8| | 9| 9| 2| 3| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Erosion | 4 2 | Inflammation, Chronic Active | | Ulcer | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| Inflammation, Chronic Active | 1 | Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 | Hematopoietic Cell Proliferation | | Hemorrhage | | Hyperplasia | 1 1 1 1 | Vacuolization Cytoplasmic | 1 2 1 4 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 2 2 2 3 3 4| Pars Distalis, Cyst | 2 2 2 1 2 1 4 3 | Pars Distalis, Hemorrhage | | Pars Distalis, Hyperplasia | 3 1 4 1 1 2 4 1 2 2 4 1 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 1 1 1 1 1 1 2 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | 1 | Inflammation, Acute | 2 | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 3 | Duct, Ectasia | 1 1| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 3| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 7| 2| 4| 2| 9| 2| 8| 2| 2| 2| 9| 2| 2| 2| 9| 2| 2| 2| 2| 2| 3| 8| | 9| 9| 2| 3| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cyst | 2 | Inflammation, Chronic | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 1 1| Necrosis | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | | Fibrosis | 1 | Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + + + + | Iliac, Congestion | 2 | Mediastinal, Congestion | 2 | Mediastinal, Pigmentation | | Renal, Congestion | 1 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | Ectasia | 1 2 | Hyperplasia, Lymphoid | 3 | Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 2| Hemorrhage | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Parathyroid Gland | | Inflammation, Acute | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 3 | Hyperplasia | 2 3 3 | Duct, Dilatation | 1 1 3 1 3 1 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Inflammation, Acute | 2 | Inflammation, Chronic | 3 | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 3| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 7| 2| 4| 2| 9| 2| 8| 2| 2| 2| 9| 2| 2| 2| 9| 2| 2| 2| 2| 2| 3| 8| | 9| 9| 2| 3| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 3 3 3 4 2 | __________________________________________________________________________| Skeletal Muscle | + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | Inflammation, Chronic | 1 2 1 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2| Inflammation, Chronic | | Inflammation, Chronic Active | 3 2 1 1 1 1 | Nasolacrimal Duct, Inflammation, | | Chronic Active | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Inflammation, Chronic | 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 2| Mineralization | 1 2 | Nephropathy | 2 2 1 1 2 1 1 2 2 2 1 1 1 1 1 1 1 2 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| | | 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectopic Pancreas | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 2 | 2 2.5| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 38 | Clear Cell Focus | X X| 4 | Congestion | 2 | 4 1.8| Developmental Malformation | X | 1 | Eosinophilic Focus | X X X X X X X X X X X | 19 | Fibrosis | | 1 1.0| Hepatodiaphragmatic Nodule | X X X X| 9 | Inflammation, Chronic Active | 1 1 1 | 9 1.3| Mitotic Alteration | | 1 1.0| Mixed Cell Focus | X | 2 | Necrosis | 1 1 | 6 1.2| Pigmentation | 1 1 1 | 6 1.5| Tension Lipidosis | | 3 | Vacuolization Cytoplasmic | 2 2 1 1 2 | 10 1.8| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 20 1.0| Centrilobular, Degeneration | 2 | 1 2.0| Centrilobular, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + + + | 9 | Fat, Necrosis | 2 2 2 2 2 | 8 2.0| __________________________________________________________________________|____________| Oral Mucosa | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 1 1 1 1 1 1 1 1| 22 1.1| Cytoplasmic Alteration | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| | | 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Inflammation, Acute | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 2 3.0| Ulcer | 3 2 | 3 2.7| Epithelium, Hyperplasia, Squamous | 4 3 | 2 3.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 4 2 4 | 6 2.8| Inflammation, Chronic Active | 3 | 1 3.0| Ulcer | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 1 1 2 2 2 1 2 1 1 1 1 1 1| 42 1.2| Inflammation, Chronic Active | | 1 1.0| Mineralization | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 1 2.0| Hematopoietic Cell Proliferation | 1 | 1 1.0| Hemorrhage | 2 | 1 2.0| Hyperplasia | 1 2 1 2 2 1 1| 11 1.3| Vacuolization Cytoplasmic | 1 2 | 6 1.8| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 1 | 5 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Angiectasis | 3 3 3 2 | 11 2.7| Pars Distalis, Cyst | 1 2 3 2 2 1 2 2| 16 2.0| Pars Distalis, Hemorrhage | 2 | 1 2.0| Pars Distalis, Hyperplasia | 2 3 4 4 4 4 1 1 4 2 | 22 2.5| Pars Intermedia, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 3 1 2 | 16 1.3| Follicular Cell, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| | | 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia | | 1 1.0| Inflammation, Acute | | 1 2.0| Inflammation, Chronic | 1 1 | 3 1.0| Inflammation, Chronic Active | | 1 3.0| Duct, Ectasia | 1 | 3 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 2.0| Cyst | 2 4 | 3 2.7| Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 1 1 1 1 | 6 1.0| Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Cellular | 3 | 1 3.0| Fibrosis | | 1 1.0| Hyperplasia | 2 2 | 3 2.0| __________________________________________________________________________|____________| Lymph Node | + + + | 7 | Iliac, Congestion | 2 | 2 2.0| Mediastinal, Congestion | 2 2 | 3 2.0| Mediastinal, Pigmentation | 3 | 1 3.0| Renal, Congestion | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 1.0| Ectasia | 1 | 3 1.3| Hyperplasia, Lymphoid | | 1 3.0| Hyperplasia, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | Congestion | | 2 2.0| Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Fibrosis | 2 | 2 2.0| Hematopoietic Cell Proliferation | 4 | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectopic Parathyroid Gland | X X | 2 | Inflammation, Acute | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| | | 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | 2 3 | 3 2.7| Hyperplasia | 1 2 | 5 2.2| Duct, Dilatation | 4 4 1 1 3 2 | 13 2.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 2 4 | 2 3.0| Inflammation, Acute | | 1 2.0| Inflammation, Chronic | | 1 3.0| Inflammation, Chronic Active | 3 2 | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 1 2 2 3| 9 2.6| __________________________________________________________________________|____________| Skeletal Muscle | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 2.0| Infiltration Cellular, Histiocyte | 1 1 1 1 1| 13 1.0| Inflammation, Chronic | 2 1 1 1 | 9 1.2| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Inflammation, Chronic | 1 1 | 2 1.0| Inflammation, Chronic Active | 1 1 1 3 3 2 2 1 2 | 15 1.7| Nasolacrimal Duct, Inflammation, | | | Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | Inflammation, Chronic | | 1 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| | | 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 2 2.0| Mineralization | 1 | 3 1.3| Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 2 1 4 1 1 1 1 2 1| 41 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| DAY ON TEST | 2| 9| 2| 2| 2| 3| 2| 2| 1| 3| 2| 3| 5| 2| 8| 2| 2| 2| 4| 2| 3| 3| 1| 3| 3| | 9| 5| 9| 9| 9| 0| 9| 9| 7| 0| 9| 3| 0| 9| 8| 9| 9| 9| 6| 9| 0| 0| 1| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 4 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X X X X X X X X | Clear Cell Focus | X X X X X | Congestion | | Developmental Malformation | X X | Eosinophilic Focus | X X X X X X X X X X X X| Fibrosis | | Hematopoietic Cell Proliferation | 2 | Hemorrhage | | Hepatodiaphragmatic Nodule | X X X X X | Inflammation, Chronic Active | | Mixed Cell Focus | X X | Necrosis | 3 | Pigmentation | 1 | Tension Lipidosis | X | Vacuolization Cytoplasmic | 1 1 | Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 | Centrilobular, Cytomegaly | | Centrilobular, Degeneration | 2 3 | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + + + + | Fat, Necrosis | 2 2 2 2 2 | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Inflammation, Acute | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 2 2 1 1| Ectopic Liver | X X | Hyperplasia | 4 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Cytoplasmic Alteration | 1 | Inflammation, Chronic | 3 | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| DAY ON TEST | 2| 9| 2| 2| 2| 3| 2| 2| 1| 3| 2| 3| 5| 2| 8| 2| 2| 2| 4| 2| 3| 3| 1| 3| 3| | 9| 5| 9| 9| 9| 0| 9| 9| 7| 0| 9| 3| 0| 9| 8| 9| 9| 9| 6| 9| 0| 0| 1| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Ulcer | 3 2 3 | Epithelium, Hyperplasia, Squamous | 2 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 1 4 3 2 | Ulcer | 4 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 2 2 1 1 1 2 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Cyst | | Hyperplasia | 1 2 1| Vacuolization Cytoplasmic | 3 1 1 2 2 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 1 1 2 1 | Necrosis | 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 3 1 3 3 4| Pars Distalis, Cyst | 2 2 3 2 2 2 2 2 | Pars Distalis, Ectasia | 3 | Pars Distalis, Hyperplasia | 3 4 4 3 1 4 1 4 2 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | 2 2 | C-Cell, Hyperplasia | 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 | Inflammation, Acute | 3 | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 2 | Duct, Ectasia | 2 3 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 2 4 | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| DAY ON TEST | 2| 9| 2| 2| 2| 3| 2| 2| 1| 3| 2| 3| 5| 2| 8| 2| 2| 2| 4| 2| 3| 3| 1| 3| 3| | 9| 5| 9| 9| 9| 0| 9| 9| 7| 0| 9| 3| 0| 9| 8| 9| 9| 9| 6| 9| 0| 0| 1| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Hyperplasia | 2 | Bilateral, Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | | Dilatation | 4 | Hemorrhage | | Inflammation, Chronic | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperplasia | 1 3 | Hyperplasia, Reticulum Cell | 3 | Myeloid Cell, Hyperplasia | 4 | __________________________________________________________________________| Lymph Node | + + + + + + +| Mediastinal, Congestion | | Pancreatic, Pigmentation | | Renal, Congestion | | Renal, Ectasia | 2| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 1 | Ectasia | 1 2 1 | Hyperplasia, Lymphoid | | Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 1 | Hematopoietic Cell Proliferation | 4 | Hemorrhage | 2 | Metaplasia, Osseous | | Necrosis | 1 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Parathyroid Gland | | Fibrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 4 2 2 | Hyperplasia | | Duct, Dilatation | 2 1 1 2 3 1 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| DAY ON TEST | 2| 9| 2| 2| 2| 3| 2| 2| 1| 3| 2| 3| 5| 2| 8| 2| 2| 2| 4| 2| 3| 3| 1| 3| 3| | 9| 5| 9| 9| 9| 0| 9| 9| 7| 0| 9| 3| 0| 9| 8| 9| 9| 9| 6| 9| 0| 0| 1| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Hyperplasia, Squamous | | Inflammation, Chronic Active | | Subcutaneous Tissue, Fibrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 2 2 3 2 3 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 1 1 1 | Inflammation, Chronic | 3 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 | Inflammation, Chronic Active | 3 1 3 3 1 1| Nasolacrimal Duct, Cyst | 2 | __________________________________________________________________________| Pleura | + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 3 | Nephropathy | 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 3| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic | 1 1 | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| | DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| | | 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Lymphoid | 1 | 2 1.5| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 2 2.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X | 28 | Clear Cell Focus | X X X X | 9 | Congestion | 2 | 1 2.0| Developmental Malformation | | 2 | Eosinophilic Focus | X X X X X X X X X X X X| 24 | Fibrosis | 1 | 1 1.0| Hematopoietic Cell Proliferation | | 1 2.0| Hemorrhage | 2 | 1 2.0| Hepatodiaphragmatic Nodule | X X X | 8 | Inflammation, Chronic Active | 1 | 1 1.0| Mixed Cell Focus | X X | 4 | Necrosis | | 1 3.0| Pigmentation | 2 | 2 1.5| Tension Lipidosis | | 1 | Vacuolization Cytoplasmic | 1 1 1 1 1 | 7 1.0| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.1| Centrilobular, Cytomegaly | 1 | 1 1.0| Centrilobular, Degeneration | | 2 2.5| Centrilobular, Necrosis | 2 1 | 2 1.5| __________________________________________________________________________|____________| Mesentery | + + + + +| 11 | Fat, Necrosis | 2 2 2 2| 9 2.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Inflammation, Acute | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 3 2 1 | 14 1.4| Ectopic Liver | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| | DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| | | 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Hyperplasia | 1 | 3 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 | 2 1.5| Cytoplasmic Alteration | | 1 1.0| Inflammation, Chronic | 1 | 2 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| Ulcer | | 3 2.7| Epithelium, Hyperplasia, Squamous | | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 2 3 1 1 2| 9 2.1| Ulcer | | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1| 43 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 4 | 1 4.0| Cyst | 3 | 1 3.0| Hyperplasia | 2 1 1 1 2 1 2 1 1 | 12 1.3| Vacuolization Cytoplasmic | 3 1| 8 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 | 7 1.7| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 3 3 1 | 9 2.6| Pars Distalis, Cyst | 1 2 1 1 2 1 3 1 2 2 | 18 1.8| Pars Distalis, Ectasia | | 1 3.0| Pars Distalis, Hyperplasia | 1 1 2 1 1 2 3 4 1 3 1 3 4 2 2 1 2 1 | 29 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | 1 | 3 1.7| C-Cell, Hyperplasia | 1 1 1 1 3 1 2 2 1 1 | 17 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| | DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| | | 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + M + + + M + + + + + + + + + + +| 48 | Hyperplasia | | 2 2.5| Inflammation, Acute | 2 | 2 2.5| Inflammation, Chronic | | 1 1.0| Inflammation, Chronic Active | | 1 2.0| Duct, Ectasia | 3 1 | 5 2.4| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 4 4 4 3 | 7 3.6| Hyperplasia | | 1 2.0| Bilateral, Cyst | 4 | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 | 1 3.0| Cyst | 4 | 1 4.0| Dilatation | | 1 4.0| Hemorrhage | 3 | 1 3.0| Inflammation, Chronic | 3 | 1 3.0| Inflammation, Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 1 | 1 1.0| Hyperplasia | 1 1| 4 1.5| Hyperplasia, Reticulum Cell | | 1 3.0| Myeloid Cell, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + | 9 | Mediastinal, Congestion | 1 | 1 1.0| Pancreatic, Pigmentation | 2 | 1 2.0| Renal, Congestion | 1 | 1 1.0| Renal, Ectasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 1.0| Ectasia | 3 | 4 1.8| Hyperplasia, Lymphoid | 2 | 1 2.0| Infiltration Cellular, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 2 | 2 2.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 | 3 2.0| Hematopoietic Cell Proliferation | 1 1 1| 4 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| | DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| | | 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemorrhage | 2| 2 2.0| Metaplasia, Osseous | 2 | 1 2.0| Necrosis | | 1 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectopic Parathyroid Gland | X | 1 | Fibrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | 2 2 | 5 2.4| Hyperplasia | 2 1 | 2 1.5| Duct, Dilatation | 1 1 | 9 1.4| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Subcutaneous Tissue, Fibrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 1 1 3 2 1 1 1 | 12 1.8| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 10 1.0| Inflammation, Chronic | 1 1 2 1 1 | 8 1.4| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 1.0| Inflammation, Chronic Active | 1 1 1 3 1 1 1 3 3 | 15 1.8| Nasolacrimal Duct, Cyst | 1 | 2 1.5| __________________________________________________________________________|____________| Pleura | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| | DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| | | 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | 4 | 2 3.5| Nephropathy | 1 1 1 1 1 2 1 1 1 3 1 2 1 1 1 1 1 1 2 3 2 | 42 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic | 1 | 3 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| DAY ON TEST | 2| 7| 0| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 6| 2| 2| 8| 2| 9| 1| | 1| 3| 7| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 7| 9| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 200 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 1 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 1 1 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 | Basophilic Focus | X X X X X X | Clear Cell Focus | X X X X X X X X | Congestion | | Developmental Malformation | | Eosinophilic Focus | X X X X X X X X X X | Hematopoietic Cell Proliferation | 2 | Hemorrhage | | Hepatodiaphragmatic Nodule | X X | Inflammation, Chronic Active | 1 | Mixed Cell Focus | | Necrosis | 1 | Pigmentation | 1 | Vacuolization Cytoplasmic | 4 1 1 2 1 1 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Centrilobular, Cytomegaly | 1 1 | Centrilobular, Degeneration | | Centrilobular, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + + + | Ectopic Spleen | | Fat, Necrosis | 2 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 3 1 1 | Ectopic Liver | X | Hyperplasia | 3 | Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| DAY ON TEST | 2| 7| 0| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 6| 2| 2| 8| 2| 9| 1| | 1| 3| 7| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 7| 9| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 200 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Fibrosis | | Inflammation, Acute | 1 | Inflammation, Chronic | | Inflammation, Chronic Active | 3 4| Ulcer | | Epithelium, Hyperplasia, Squamous | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 3 2 | Mineralization | 2 | Ulcer | 3 4 | __________________________________________________________________________| Tongue | | Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 1 2 1 | Vacuolization Cytoplasmic | 1 2 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation | | Pars Distalis, Angiectasis | 3 3 4 2 2 2 3 | Pars Distalis, Cyst | 2 2 2 2 3 2 2 2 1 3 | Pars Distalis, Hyperplasia | 2 4 2 3 2 4 1 3 1 2 4 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 3 2 1 2 4 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic | 1 1 1 | Inflammation, Chronic Active | 2 4| _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| DAY ON TEST | 2| 7| 0| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 6| 2| 2| 8| 2| 9| 1| | 1| 3| 7| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 7| 9| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 200 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Bilateral, Inflammation, Acute | | Duct, Ectasia | 3 3 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 4 | Pigmentation | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | | Dilatation | | Hyperplasia, Cystic | 2 1 1 | Metaplasia, Squamous | | Cervix, Hypertrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 4 | Necrosis | | Erythroid Cell, Hyperplasia | | __________________________________________________________________________| Lymph Node | + + + +| Mediastinal, Congestion | | Mediastinal, Hyperplasia, Lymphoid | | Pancreatic, Congestion | | Renal, Congestion | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Ectasia | 1 2 1 1 1 1 1 | Necrosis | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Ectasia | 3 1 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Fibrosis | 2 4 1| Necrosis | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Cyst | 1 | Ectopic Parathyroid Gland | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 3 | Hyperplasia | 2 3 | Inflammation, Chronic Active | 4 | Duct, Dilatation | 2 2 1 1 1 2 4| _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| DAY ON TEST | 2| 7| 0| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 6| 2| 2| 8| 2| 9| 1| | 1| 3| 7| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 7| 9| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 200 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 4 | Hyperplasia, Squamous | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 1 3 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 1 1 | Inflammation, Chronic | 1 1 2 | Bronchiole, Alveolus, Hyperplasia | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Inflammation, Chronic | 1 1 1 | Inflammation, Chronic Active | 1 1 2 1 1 1 3| Nasolacrimal Duct, Inflammation, | | Chronic Active | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Hemorrhage | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Cyst | 1 | Mineralization | 1 1 1| Nephropathy | 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1 1| Pigmentation | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| | | 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | | 1 1.0| Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | | 2 1.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 3 1.7| Basophilic Focus | X X X X X | 11 | Clear Cell Focus | X X X | 11 | Congestion | 2 2 3 | 3 2.3| Developmental Malformation | X | 1 | Eosinophilic Focus | X X X X X X X X X X X X| 22 | Hematopoietic Cell Proliferation | | 1 2.0| Hemorrhage | 3 | 1 3.0| Hepatodiaphragmatic Nodule | X | 3 | Inflammation, Chronic Active | 1 | 2 1.0| Mixed Cell Focus | X | 1 | Necrosis | | 1 1.0| Pigmentation | 3 3 4 1 2 | 6 2.3| Vacuolization Cytoplasmic | 4 1 1| 9 1.8| Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 34 1.0| Centrilobular, Cytomegaly | 1 1 | 4 1.0| Centrilobular, Degeneration | 1 2 | 2 1.5| Centrilobular, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + | 7 | Ectopic Spleen | X | 1 | Fat, Necrosis | 2 2 | 6 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 1 1 1 1 1 | 13 1.2| Ectopic Liver | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| | | 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Hyperplasia | 2 | 2 2.5| Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 | 3 1.3| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 1 2.0| Inflammation, Acute | | 1 1.0| Inflammation, Chronic | 2 | 1 2.0| Inflammation, Chronic Active | | 2 3.5| Ulcer | 3 3 3 3 | 4 3.0| Epithelium, Hyperplasia, Squamous | 3 2 | 2 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 3 4 3 1 2 2 2 | 9 2.4| Mineralization | 1 | 2 1.5| Ulcer | 2 | 3 3.0| __________________________________________________________________________|____________| Tongue | + | 1 | Epithelium, Hyperplasia | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 2 1 1 1 1 1 1 2 1 1 2 2 1 1 1 2 2 1 1 1| 43 1.2| Thrombosis | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 | 1 4.0| Hyperplasia | 2 1 2 1 1 1| 9 1.3| Vacuolization Cytoplasmic | 3 2 | 6 1.7| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 1 2 4 2 | 8 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + M + + M + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pigmentation | 2 | 1 2.0| Pars Distalis, Angiectasis | 2 2 2 4 2| 12 2.6| Pars Distalis, Cyst | 2 2 3 3 2 2 2 2 2 1 | 20 2.1| Pars Distalis, Hyperplasia | 4 1 2 1 4 2 2 1 2 2 | 21 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| | | 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Hyperplasia | 1 1 1 1 2 4 | 13 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3| 1 3.0| Inflammation, Chronic | 1 1 | 5 1.0| Inflammation, Chronic Active | | 2 3.0| Bilateral, Inflammation, Acute | 4 | 1 4.0| Duct, Ectasia | 3| 4 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 3 | 4 3.0| Pigmentation | 2 | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Developmental Malformation | X | 1 | Dilatation | 4 | 1 4.0| Hyperplasia, Cystic | 1 1 | 5 1.2| Metaplasia, Squamous | 2 | 1 2.0| Cervix, Hypertrophy | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Cellular | 2 | 2 3.0| Necrosis | 2 | 1 2.0| Erythroid Cell, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + | 15 | Mediastinal, Congestion | 2 3 2 3 | 4 2.5| Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0| Pancreatic, Congestion | 3 | 1 3.0| Renal, Congestion | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 1 2.0| Ectasia | 1 1 | 9 1.1| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 2 2 | 3 2.0| Ectasia | 2 | 4 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| | | 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 4 | 2 3.5| Fibrosis | | 3 2.3| Necrosis | 4 | 2 3.5| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Cyst | | 1 1.0| Ectopic Parathyroid Gland | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | | 1 3.0| Hyperplasia | 3 1 2 3 | 6 2.3| Inflammation, Chronic Active | | 1 4.0| Duct, Dilatation | 1 2 1 1 4 1 | 13 1.8| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | 4 | 2 4.0| Hyperplasia, Squamous | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 3 2 4 4 1 2 1 | 10 2.4| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 | 9 1.1| Inflammation, Chronic | 1 1 1 | 6 1.2| Bronchiole, Alveolus, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Inflammation, Chronic | | 3 1.0| Inflammation, Chronic Active | 2 2 1 3 4 1 3 1 1| 16 1.8| Nasolacrimal Duct, Inflammation, | | | Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| | | 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 2.0| Cyst | | 1 1.0| Mineralization | 2 | 4 1.3| Nephropathy | 2 2 1 1 2 2 1 1 1 2 2 2 3 1 1 1 1 1 1| 35 1.3| Pigmentation | 3 2 | 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1| 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 5| 6| 6| 7| 7| 5| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 1| 1| 7| 2| 2| 0| 2| 5| 3| 2| 2| 8| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 1| | 9| 1| 6| 3| 9| 9| 3| 9| 7| 0| 9| 9| 9| 9| 9| 5| 8| 9| 9| 9| 9| 9| 9| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 400 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 2 2 2 | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Clear Cell Focus | X X X X X X X X X X X | Congestion | 2 2 | Eosinophilic Focus | X X X X X X X X 2 X X | Hematopoietic Cell Proliferation | 1 | Hepatodiaphragmatic Nodule | X X | Inflammation, Chronic Active | 1 1 | Mitotic Alteration | | Mixed Cell Focus | X X X X X | Pigmentation | 2 1 1 1 1 1 2 1 3 3 | Vacuolization Cytoplasmic | 2 3 3 1 2 1 1 1 2 1 2 1 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Capsule, Inflammation, Chronic | | Centrilobular, Cytomegaly | 1 2 1 1 1 2 2 1 1 1 1 | Centrilobular, Degeneration | 1 2 1 | __________________________________________________________________________| Mesentery | + + + + + +| Inflammation | | Fat, Necrosis | 2 2 2 2 2| __________________________________________________________________________| Oral Mucosa | + + | Pharyngeal, Hyperplasia | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 2 2 1 1 | Ectopic Liver | X | Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | Cytoplasmic Alteration | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Inflammation, Chronic Active | | Ulcer | 3| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 5| 6| 6| 7| 7| 5| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 1| 1| 7| 2| 2| 0| 2| 5| 3| 2| 2| 8| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 1| | 9| 1| 6| 3| 9| 9| 3| 9| 7| 0| 9| 9| 9| 9| 9| 5| 8| 9| 9| 9| 9| 9| 9| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 400 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Epithelium, Hyperplasia, Squamous | 3| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 1 4 | Inflammation, Chronic | | __________________________________________________________________________| Tongue | | Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Cyst | | Hyperplasia | 4 1 | Vacuolization Cytoplasmic | 1 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | 3 1 2 3 2 | Pars Distalis, Hyperplasia | 1 2 1 1 2 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | 2 | C-Cell, Hyperplasia | 1 2 3 1 1 4 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic | 1 2 | Inflammation, Chronic Active | | Vacuolization Cytoplasmic | | Duct, Ectasia | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 5| 6| 6| 7| 7| 5| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 1| 1| 7| 2| 2| 0| 2| 5| 3| 2| 2| 8| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 1| | 9| 1| 6| 3| 9| 9| 3| 9| 7| 0| 9| 9| 9| 9| 9| 5| 8| 9| 9| 9| 9| 9| 9| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 400 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Bilateral, Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Dilatation | 3 2 | Hemorrhage | | Hyperplasia, Cystic | 4 1 1 2 2 | Hyperplasia | 2 | Inflammation, Acute | 4 | Inflammation, Chronic | | Necrosis | | Cervix, Inflammation, Chronic | | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 2 | Hyperplasia | | __________________________________________________________________________| Lymph Node | + + + + + + +| Iliac, Ectasia | 2 | Mediastinal, Congestion | | Mediastinal, Pigmentation | | Renal, Ectasia | | Renal, Hyperplasia, Lymphoid | 1 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 | Edema | 4 | Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 1 2 | Inflammation, Acute | 3 | Inflammation, Chronic | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Fibrosis | 2 1 2| Hematopoietic Cell Proliferation | 3 | Necrosis | 2| Pigmentation | | Capsule, Inflammation, Chronic | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Parathyroid Gland | | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 5| 6| 6| 7| 7| 5| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 1| 1| 7| 2| 2| 0| 2| 5| 3| 2| 2| 8| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 1| | 9| 1| 6| 3| 9| 9| 3| 9| 7| 0| 9| 9| 9| 9| 9| 5| 8| 9| 9| 9| 9| 9| 9| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 400 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Hyperplasia | | Duct, Dilatation | 1 2 1 3 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Inflammation, Acute | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 | Inflammation, Chronic | 1 1 3 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 3 1 1 2 2 1 3 1 1 1 2 | Respiratory Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Hemorrhage | 2 3 | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | | Inflammation, Acute | 3 | Mineralization | 1 1 1 1 | Nephropathy | 1 1 1 3 1 1 1 1 1 1 1 1 1 2 2 1 1 1 | Pigmentation | 1 | Renal Tubule, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| | DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| | | 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 2 | 5 2.0| Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 2 1.0| Clear Cell Focus | X X X X X| 16 | Congestion | | 2 2.0| Eosinophilic Focus | X X X X| 15 2.0| Hematopoietic Cell Proliferation | 1 | 2 1.0| Hepatodiaphragmatic Nodule | X | 3 | Inflammation, Chronic Active | 1 1 | 4 1.0| Mitotic Alteration | 2 | 1 2.0| Mixed Cell Focus | | 5 | Pigmentation | 2 1 2 2 1 2 1| 17 1.6| Vacuolization Cytoplasmic | 1 1 1 2 2 1| 18 1.6| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0| Capsule, Inflammation, Chronic | 2 2 | 2 2.0| Centrilobular, Cytomegaly | 2 2 1 2 2 1 2 1 1| 20 1.4| Centrilobular, Degeneration | 1 1 1 1| 7 1.1| __________________________________________________________________________|____________| Mesentery | + + + + + + | 12 | Inflammation | 3 | 1 3.0| Fat, Necrosis | 1 2 2 2 2 2 | 11 1.9| __________________________________________________________________________|____________| Oral Mucosa | | 2 | Pharyngeal, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 1 1 1| 14 1.1| Ectopic Liver | X X | 3 | Inflammation, Chronic | 2 3 | 2 2.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| | DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| | | 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Cytoplasmic Alteration | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 4 | 1 4.0| Inflammation, Chronic Active | 3 | 1 3.0| Ulcer | 2 2 3 | 4 2.5| Epithelium, Hyperplasia, Squamous | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 2 4 2 1 | 7 2.1| Inflammation, Chronic | 4 | 1 4.0| __________________________________________________________________________|____________| Tongue | + + | 2 | Epithelium, Hyperplasia | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1| 36 1.1| Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 4 | 1 4.0| Cyst | 3 | 1 3.0| Hyperplasia | 1 1 1 2 | 6 1.7| Vacuolization Cytoplasmic | 1 | 3 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 3 | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 1 2 | 4 1.8| Pars Distalis, Cyst | 2 2 2 | 8 2.1| Pars Distalis, Hyperplasia | 1 2 2 4 2 3 4 4 3 2 1| 18 2.1| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | | 1 2.0| C-Cell, Hyperplasia | 1 1 1 1 | 10 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| | DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| | | 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 2| 2 2.5| Inflammation, Chronic | | 2 1.5| Inflammation, Chronic Active | 1 | 1 1.0| Vacuolization Cytoplasmic | 1 | 1 1.0| Duct, Ectasia | 2 3 | 2 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 1 | 2 1.5| Inflammation, Chronic | 3 | 1 3.0| Bilateral, Cyst | 4 4 | 2 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 1 2.0| Dilatation | | 2 2.5| Hemorrhage | 3 | 1 3.0| Hyperplasia, Cystic | 1 1 | 7 1.7| Hyperplasia | | 1 2.0| Inflammation, Acute | | 1 4.0| Inflammation, Chronic | 4 | 1 4.0| Necrosis | 4 | 1 4.0| Cervix, Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Cellular | 2 | 2 2.0| Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + | 19 | Iliac, Ectasia | 2 | 2 2.0| Mediastinal, Congestion | 1 | 1 1.0| Mediastinal, Pigmentation | 2 | 1 2.0| Renal, Ectasia | 1 | 1 1.0| Renal, Hyperplasia, Lymphoid | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 1| 2 1.0| Edema | | 1 4.0| Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| | DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| | | 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Inflammation, Acute | | 1 3.0| Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| Fibrosis | 3 | 4 2.0| Hematopoietic Cell Proliferation | 3 | 2 3.0| Necrosis | | 1 2.0| Pigmentation | 2 | 1 2.0| Capsule, Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectopic Parathyroid Gland | X X | 2 | Inflammation, Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 3 1 2 2 | 5 2.0| Duct, Dilatation | 1 2 1 1 1 1 2 1 | 13 1.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 3 | 1 3.0| Inflammation, Acute | 2 | 1 2.0| Inflammation, Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | 1 2 3 1 | 5 1.8| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 2 2.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 1.0| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1| 11 1.0| Inflammation, Chronic | 2 1 1 | 8 1.4| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| Inflammation, Chronic Active | 3 3 2 3 2 1 1 2 | 19 1.8| Respiratory Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| | DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| | | 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Hemorrhage | | 2 2.5| __________________________________________________________________________|____________| Zymbal's Gland | +| 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accumulation, Hyaline Droplet | 3 | 1 3.0| Inflammation, Acute | | 1 3.0| Mineralization | 1 1 | 6 1.0| Nephropathy | 1 2 2 3 1 1 1 1 2 2 1 2 1 2 1 1 1 1 1| 37 1.3| Pigmentation | | 1 1.0| Renal Tubule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 2 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 6| 7| 7| 6| 5| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 7| 3| DAY ON TEST | 9| 9| 1| 4| 1| 2| 0| 2| 2| 0| 9| 8| 1| 2| 7| 1| 2| 2| 6| 2| 2| 0| 7| 2| 0| | 5| 2| 9| 0| 8| 2| 4| 2| 2| 2| 5| 8| 9| 2| 9| 8| 2| 2| 7| 2| 2| 1| 3| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 4 | Ulcer | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperplasia, Lymphoid | 2 2 2 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X | Clear Cell Focus | X X X | Congestion | | Degeneration, Cystic | 1 3 | Eosinophilic Focus | X X X X X X X | Fibrosis | | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X | Necrosis | 1 | Pigmentation | 1 1 | Vacuolization Cytoplasmic | 3 1 1 | Bile Duct, Hyperplasia | 1 2 1 1 3 1 1 2 1 1 1 2 1 3 1 1 3 1 3 3 1 1 | Centrilobular, Degeneration | 2 | __________________________________________________________________________| Mesentery | + + + + + + + + | Cyst | 2 | Fat, Necrosis | 3 3 2 2 2 2 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 1 2 1 1 1 2 | Cytoplasmic Alteration | | Hyperplasia | 4 | Inflammation, Chronic | | Artery, Inflammation, Acute | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 4 | Ulcer | 3 | Epithelium, Hyperplasia, Squamous | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 6| 7| 7| 6| 5| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 7| 3| DAY ON TEST | 9| 9| 1| 4| 1| 2| 0| 2| 2| 0| 9| 8| 1| 2| 7| 1| 2| 2| 6| 2| 2| 0| 7| 2| 0| | 5| 2| 9| 0| 8| 2| 4| 2| 2| 2| 5| 8| 9| 2| 9| 8| 2| 2| 7| 2| 2| 1| 3| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Erosion | 4 4 2 2 4 2 2 2 1 3 1 | Inflammation, Chronic | 2| Ulcer | 2 2 | __________________________________________________________________________| Tooth | + + | Inflammation, Acute | 2 | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 1 1 2 2 1 3 2 2 1 2 1 2 2 1 1 1 1| Mineralization | | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 | Hyperplasia | 2 1 1 1 1 2 | Hypertrophy | | Vacuolization Cytoplasmic | 3 2 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 2 3 3 3 | Bilateral, Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 4 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 2 | Pars Distalis, Hemorrhage | 3 | Pars Distalis, Hyperplasia | 2 4 1 2 4 4 3 2 1 4 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | 1| C-Cell, Hyperplasia | 1 1 1 1 | Follicle, Dilatation | | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | | Inflammation, Chronic Active | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 6| 7| 7| 6| 5| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 7| 3| DAY ON TEST | 9| 9| 1| 4| 1| 2| 0| 2| 2| 0| 9| 8| 1| 2| 7| 1| 2| 2| 6| 2| 2| 0| 7| 2| 0| | 5| 2| 9| 0| 8| 2| 4| 2| 2| 2| 5| 8| 9| 2| 9| 8| 2| 2| 7| 2| 2| 1| 3| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Hyperplasia | 4 2 | Inflammation, Acute | 2 | Inflammation, Chronic | 2 1 1 1 1 2| Inflammation, Chronic Active | 2 2 1 1 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Inflammation, Acute | 4 | Inflammation, Chronic | 1 3 | Inflammation, Chronic Active | 3 3 2 3 1 3 2 1 1 2 1 2 1 1 1 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 | Necrosis | 4 | Bilateral, Interstitial Cell, | | Hyperplasia | 2 4 1 | Interstitial Cell, Hyperplasia | 4 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + +| Iliac, Hyperplasia, Lymphoid | | Iliac, Infiltration Cellular, Plasma | | Cell | 4 | Mediastinal, Hemorrhage | | Renal, Congestion | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | Inflammation, Acute | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| Fibrosis | 4 3 3 2 2 3 | Hematopoietic Cell Proliferation | | Necrosis | 3 3| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Hyperplasia | | Duct, Dilatation | 4 4 2 1 3 2 | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 6| 7| 7| 6| 5| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 7| 3| DAY ON TEST | 9| 9| 1| 4| 1| 2| 0| 2| 2| 0| 9| 8| 1| 2| 7| 1| 2| 2| 6| 2| 2| 0| 7| 2| 0| | 5| 2| 9| 0| 8| 2| 4| 2| 2| 2| 5| 8| 9| 2| 9| 8| 2| 2| 7| 2| 2| 1| 3| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 | Osteopetrosis | 4 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 2 | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Histiocyte | 1 1 | Inflammation, Chronic | 1 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 1 2 2 2 2 2 1 1 2 1 2 | Nasolacrimal Duct, Inflammation, | | Acute | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Developmental Malformation | | Hydronephrosis | 2 | Nephropathy | 4 3 1 2 2 3 3 2 1 2 1 3 3 1 3 2 3 2 3 2 2 2 1| Artery, Inflammation, Acute | | Artery, Inflammation, Chronic Active | | Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 2 | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| | | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Acute | | 1 4.0| Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 1 2.0| Hyperplasia, Lymphoid | 2 2 | 6 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X | 12 | Clear Cell Focus | X X X X | 7 | Congestion | 2 | 1 2.0| Degeneration, Cystic | 1 1 | 4 1.5| Eosinophilic Focus | X X X X X X X| 14 | Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 1 1 | 2 1.0| Hepatodiaphragmatic Nodule | X | 3 | Mixed Cell Focus | X | 2 | Necrosis | 1 | 2 1.0| Pigmentation | 1 1 | 4 1.0| Vacuolization Cytoplasmic | 1 | 4 1.5| Bile Duct, Hyperplasia | 1 1 1 1 3 1 1 1 1 3 1 1 2 1 2 1 1 1 1 1 1 1 1 1| 46 1.4| Centrilobular, Degeneration | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + +| 11 | Cyst | | 1 2.0| Fat, Necrosis | 2 2 2| 10 2.2| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 2 1 1 1 1 1 1 1 1 1 | 18 1.3| Cytoplasmic Alteration | 1 1 | 2 1.0| Hyperplasia | 1 | 2 2.5| Inflammation, Chronic | 3 | 1 3.0| Artery, Inflammation, Acute | 4 | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| | | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 2 3.0| Ulcer | 3 | 2 3.0| Epithelium, Hyperplasia, Squamous | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 4 4 1 3 | 15 2.6| Inflammation, Chronic | | 1 2.0| Ulcer | | 2 2.0| __________________________________________________________________________|____________| Tooth | | 2 | Inflammation, Acute | | 1 2.0| Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 1 2 2 2 3 2 2 2 1 3 1 3 2 1 1 2 1 1 1 2 2 2| 45 1.7| Mineralization | 2 | 1 2.0| Thrombosis | 3 2 | 2 2.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 1 2.0| Hyperplasia | 2 2 | 8 1.5| Hypertrophy | 2 | 1 2.0| Vacuolization Cytoplasmic | 1 2 1 1 3 2 | 9 1.8| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 1 1 1 2 1 2 3 2 2 2 2| 17 2.2| Bilateral, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 5 2.4| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | 1 | 2 1.5| Pars Distalis, Hemorrhage | | 1 3.0| Pars Distalis, Hyperplasia | 1 3 1 1 1 1 2 4 3 2 1 4| 22 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | | 1 1.0| C-Cell, Hyperplasia | 1 2 1 | 7 1.1| Follicle, Dilatation | 2 | 1 2.0| Follicular Cell, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| | | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | __________________________________________________________________________|____________| Penis | + | 1 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Hyperplasia | 2 3 | 4 2.8| Inflammation, Acute | 4 | 2 3.0| Inflammation, Chronic | 1 1 2 2 1 2 1 1 1 1 1 | 17 1.3| Inflammation, Chronic Active | 2 | 5 1.6| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 1 2.0| Inflammation, Acute | 3 | 2 3.5| Inflammation, Chronic | | 2 2.0| Inflammation, Chronic Active | 3 2 2 1 2 1 2 2 2 1 1 1 1 1 1| 31 1.7| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 2.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Atrophy | | 2 2.5| Necrosis | | 1 4.0| Bilateral, Interstitial Cell, | | | Hyperplasia | | 3 2.3| Interstitial Cell, Hyperplasia | 2 3 2 2 1 2 1 | 9 2.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Cellular | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + | 20 | Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0| Iliac, Infiltration Cellular, Plasma | | | Cell | | 1 4.0| Mediastinal, Hemorrhage | 2 | 1 2.0| Renal, Congestion | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 2| 4 1.8| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| | | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Ectasia | 1 | 2 2.0| Inflammation, Acute | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 2 1 2 2 2 2 2 2| 14 2.3| Hematopoietic Cell Proliferation | 3 | 1 3.0| Necrosis | 3 3 | 4 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 | 1 1.0| Duct, Dilatation | 3 4 1 1 1 3 3 2 | 14 2.4| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 3 | 2 3.0| Osteopetrosis | | 1 4.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | | 1 2.0| Infiltration Cellular, Histiocyte | 1 1 1 1| 6 1.0| Inflammation, Chronic | 1 2 1 1 1 | 8 1.1| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 2 2 3 2 3 4 2 1 2 3 3 3| 26 2.2| Nasolacrimal Duct, Inflammation, | | | Acute | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| | | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 | 3 2.7| Developmental Malformation | X X | 2 | Hydronephrosis | 1 1 | 3 1.3| Nephropathy | 2 2 2 2 2 2 4 2 4 1 2 3 3 3 3 1 3 2 1 1 3 2 4 2| 47 2.3| Artery, Inflammation, Acute | 3 | 1 3.0| Artery, Inflammation, Chronic Active | 3 | 1 3.0| Renal Tubule, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 1 | 4 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7| DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1| | 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Parasite Metazoan | X| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hyperplasia, Lymphoid | | Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 2 1 1 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X | Clear Cell Focus | | Degeneration, Cystic | 4 2 3 2 2 2 1 | Eosinophilic Focus | X X X X X X X X X X X X | Fibrosis | | Hematopoietic Cell Proliferation | 1 | Hepatodiaphragmatic Nodule | | Mixed Cell Focus | | Necrosis | | Pigmentation | 1 2 2 1 1 | Vacuolization Cytoplasmic | 3 3 | Bile Duct, Hyperplasia | 3 1 3 2 3 2 1 1 3 2 1 1 1 1 1 1 1 3 2 1 2 1| Centrilobular, Cytomegaly | 2 | Centrilobular, Degeneration | | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + + + + + | Inflammation, Acute | | Fat, Necrosis | 2 3 2 2 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 1 2 1 3 3 2 1 | Hyperplasia | 1 2 | Acinus, Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 4 | Ulcer | 2 4 4 4 4 4 4 3 | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7| DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1| | 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Epithelium, Hyperplasia, Squamous | 3 3 1| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 1 1 3 2 2 3 3 4 2| Inflammation, Chronic | | Mineralization | | Ulcer | 3 3 3 4 | __________________________________________________________________________| Tooth | + | Dysplasia | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 2 2 1 1 1 2 2 2 2 2 2 1 2 2 2 2 2 3 3 2 1| Thrombosis | 3 3 3| Coronary Artery, Inflammation, | | Chronic Active | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 | Vacuolization Cytoplasmic | 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1 4 1 4 4 4 2 1 1 1 2 3| Bilateral, Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 4 | Pars Distalis, Cyst | 1 2 2 1| Pars Distalis, Ectasia | | Pars Distalis, Hyperplasia | 3 3 1 1 3 1 2 4 3 3 2 | Pars Distalis, Thrombosis | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation | | Ultimobranchial Cyst | 1 | C-Cell, Hyperplasia | 1 3 1 1 | Follicle, Dilatation | 2 | Follicular Cell, Hyperplasia | 2 3 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7| DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1| | 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 2 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1| Inflammation, Chronic Active | 2 1 1 1 1 2 2 4 1 | Duct, Dilatation | 3 4 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Chronic | 2 | Hyperplasia, Focal | | Inflammation, Acute | 3 4 | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 2 3 2 2 2 1 1 4 2 2 2 2 2 1 1 3| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Hyperplasia | 1 | Interstitial Cell, Hyperplasia | 2 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 2 2 2 2 | Hemorrhage | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + +| Iliac, Hyperplasia, Lymphoid | 2 | Mediastinal, Congestion | 2 2| Mediastinal, Hemorrhage | 2 | Renal, Fibrosis | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Ectasia | 1 | Inflammation, Chronic Active | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2| Ectasia | 3 2 | Hemorrhage | 2 | Necrosis | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Fibrosis | 2 2 2 2 2 2 2 | Hematopoietic Cell Proliferation | | Necrosis | 3 | Thrombosis | 2 | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7| DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1| | 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hemorrhage | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Concretion | 2 | Hyperplasia | 2 | Duct, Dilatation | 2 2 1 3 2 3 4 1 1 1 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Inflammation, Acute | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | Hyperostosis | 2 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hyperplasia, Lymphoid | 1 | Infiltration Cellular, Histiocyte | 2 1 1 | Inflammation, Chronic | 2 2 1 2 1 1 2 1| Alveolar Epithelium, Hyperplasia | 3 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Inflammation, Chronic Active | 1 1 1 3 1 2 1 2 3 3 2 | Squamous Epithelium, Nasolacrimal | | Duct, Hyperplasia | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Atrophy | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7| DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1| | 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Hydronephrosis | | Nephropathy | 2 3 2 2 2 1 2 3 3 2 1 2 2 3 3 4 4 3 1 2 2 2 2 1 2| Capsule, Hemorrhage, Chronic | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| | DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| | | 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + M + + + M + + + + +| 48 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + M + + + + +| 48 | Edema | 4 | 1 4.0| Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 | Edema | 4 | 1 4.0| Hyperplasia, Lymphoid | 2 | 1 2.0| Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 | Congestion | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 | Hyperplasia, Lymphoid | 3 2 1 2 | 9 1.9| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Angiectasis | 3 | 1 3.0| Basophilic Focus | X X X | 5 | Clear Cell Focus | X | 1 | Degeneration, Cystic | 3 3 3 1 2 | 12 2.3| Eosinophilic Focus | X X X X X X X X X X X | 23 | Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | | 1 1.0| Hepatodiaphragmatic Nodule | X | 1 | Mixed Cell Focus | X | 1 | Necrosis | 1 | 1 1.0| Pigmentation | 1 1 1 1 2 1 | 11 1.3| Vacuolization Cytoplasmic | 2 1 1 1 | 6 1.8| Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 3 1 2 3 3 1 1 1 1| 43 1.5| Centrilobular, Cytomegaly | 1 1 1 | 4 1.3| Centrilobular, Degeneration | 2 3 2 | 3 2.3| Centrilobular, Necrosis | 2 1 2 | 3 1.7| __________________________________________________________________________|____________| Mesentery | + + + + + + + | 14 | Inflammation, Acute | 2 | 1 2.0| Fat, Necrosis | 2 2 3 2 2 2 | 13 2.2| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + M + + + M + + + + + + + + +| 48 | Atrophy | 1 2 1 2 1 | 15 1.7| Hyperplasia | 2 2 | 4 1.8| Acinus, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| | DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| | | 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Inflammation, Acute | | 1 4.0| Ulcer | 3 2 | 10 3.4| Epithelium, Hyperplasia, Squamous | 3 3 1 3 | 7 2.4| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Erosion | 4 2 4 2 4 2 4 2| 17 2.6| Inflammation, Chronic | 2 | 1 2.0| Mineralization | 2 2 | 2 2.0| Ulcer | 3 | 5 3.2| __________________________________________________________________________|____________| Tooth | | 1 | Dysplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 1 1 2 1 2 1 1 2 3 2 2 2 2 2 1 1 1 2 | 43 1.7| Thrombosis | 3 2 3 | 6 2.8| Coronary Artery, Inflammation, | | | Chronic Active | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Hyperplasia | 1 1 2 3 | 7 1.9| Vacuolization Cytoplasmic | 1 4 1| 5 1.6| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Hyperplasia | 2 3 4 1 2 4 4 | 22 2.3| Bilateral, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + M + + + M + + + + + + + + +| 48 | Hyperplasia | 2 | 2 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 3 | 2 3.5| Pars Distalis, Cyst | 2 1 1 1 | 8 1.4| Pars Distalis, Ectasia | 3 | 1 3.0| Pars Distalis, Hyperplasia | 1 4 4 4 4 | 16 2.7| Pars Distalis, Thrombosis | 4 | 1 4.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| | DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| | | 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pigmentation | 1 | 1 1.0| Ultimobranchial Cyst | | 1 1.0| C-Cell, Hyperplasia | 1 | 5 1.4| Follicle, Dilatation | | 1 2.0| Follicular Cell, Hyperplasia | 1 1 | 5 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + M + + M + + + + + + + M + + + + +| 47 | Hyperplasia | | 3 2.3| Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | 25 1.1| Inflammation, Chronic Active | 2 2 4 2 1| 14 1.9| Duct, Dilatation | | 2 3.5| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + M + + + M + + + + +| 48 | Hemorrhage, Chronic | | 1 2.0| Hyperplasia, Focal | 1 | 1 1.0| Inflammation, Acute | | 2 3.5| Inflammation, Chronic | | 1 1.0| Inflammation, Chronic Active | 1 2 1 3 1 2 2 3 4 2 1 4 1 | 29 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 | Inflammation, Acute | 1 | 1 1.0| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Bilateral, Interstitial Cell, | | | Hyperplasia | 4 | 2 2.5| Interstitial Cell, Hyperplasia | 1 3 1 2 | 6 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Cellular | | 4 2.0| Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + +| 25 | Iliac, Hyperplasia, Lymphoid | | 1 2.0| Mediastinal, Congestion | 2 2 2 | 5 2.0| Mediastinal, Hemorrhage | | 1 2.0| Renal, Fibrosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| | DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| | | 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 1 2.0| Ectasia | 2 2 | 3 1.7| Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 | Congestion | 4 | 2 3.0| Ectasia | 3 | 3 2.7| Hemorrhage | | 1 2.0| Necrosis | 3 3 | 3 2.7| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + M + + + M + + + + + + + + +| 48 | Congestion | | 1 3.0| Fibrosis | 2 1 3 3 | 11 2.1| Hematopoietic Cell Proliferation | 3 | 1 3.0| Necrosis | 2 | 2 2.5| Thrombosis | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 2 | 1 2.0| Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Concretion | | 1 2.0| Hyperplasia | 1 1 | 3 1.3| Duct, Dilatation | 1 3 4 3 | 16 2.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 4 | 1 4.0| Inflammation, Acute | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 3 | 1 3.0| Hyperostosis | | 1 2.0| __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| | DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| | | 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Congestion | 3 | 1 3.0| Hyperplasia, Lymphoid | | 1 1.0| Infiltration Cellular, Histiocyte | 1 | 4 1.3| Inflammation, Chronic | 1 1 | 10 1.4| Alveolar Epithelium, Hyperplasia | 2 | 3 2.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Inflammation, Chronic Active | 3 3 4 3 2 1 1 | 18 2.1| Squamous Epithelium, Nasolacrimal | | | Duct, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Atrophy | 4 | 1 4.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + M + + + M + + + + + + + + +| 48 | Cyst | 3 | 3 2.7| Hydronephrosis | 1 | 1 1.0| Nephropathy | 2 1 3 3 2 1 1 2 3 3 4 3 1 3 3 4 1 2 2 3 2 1 | 47 2.3| Capsule, Hemorrhage, Chronic | | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 | Hemorrhage | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7| DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2| | 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | Inflammation, Acute | 3 | Inflammation, Chronic | | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Pancreas | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Clear Cell Focus | X X X | Degeneration, Cystic | 1 1 2 1 1 2 1 4| Developmental Malformation | X | Eosinophilic Focus | X X X X X X X X X X X X| Fibrosis | 1 | Mixed Cell Focus | X X | Necrosis | | Pigmentation | 1 1 3 2 2 1 2 1 1 2 1 1 | Thrombosis | 2 | Vacuolization Cytoplasmic | 1 1 2 1 1 2 | Bile Duct, Hyperplasia | 1 1 1 1 1 3 1 3 2 3 3 1 3 3 1 1 3 1 3 1 1 1 2| Centrilobular, Cytomegaly | 1 1 1 | Centrilobular, Degeneration | 1 3 | Periportal, Fibrosis | 1 | __________________________________________________________________________| Mesentery | + + + + | Hemorrhage | 3 | Fat, Necrosis | 1 2 2 | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Hyperplasia | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 2 1 1 1 1 1 | Hyperplasia | 2 3 | Inflammation, Chronic | 1 4| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | Epithelium, Hyperplasia, Squamous | 4 4 | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7| DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2| | 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 4 3 4 2 | Inflammation, Chronic Active | | Mineralization | 2 1 | Ulcer | 2 | __________________________________________________________________________| Tooth | + | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 2 1 2 2 1 3 2 2 1 2 1 2 2 1 2 2 2 2 2| Mineralization | 3 2 | Thrombosis | 2 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hyperplasia | 1 4 1 1 2 2 | Vacuolization Cytoplasmic | 3 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 1 1 4 4 1 2 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 4 4 1 1 2 1 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 | Follicle, Dilatation | | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Inflammation, Chronic | 1 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 3 | Inflammation, Chronic | 2 1 2 1 1 1 1 | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7| DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2| | 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic Active | 2 4 1 1 2 3 3| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Inflammation, Chronic | 1 1 1 1 | Inflammation, Chronic Active | 3 2 2 1 2 1 3 1 1 1 2 2 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | Inflammation, Acute | 1 | Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Thrombosis | 4 | Bilateral, Interstitial Cell, | | Hyperplasia | 2 3 | Interstitial Cell, Hyperplasia | 2 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 2 | Fibrosis | 3 | __________________________________________________________________________| Lymph Node | + + + + + + + + + +| Mediastinal, Ectasia | 2| Mediastinal, Hemorrhage | 2 | Mediastinal, Pigmentation | 2| Pancreatic, Congestion | 2 | Pancreatic, Hyperplasia, Lymphoid | | Pancreatic, Necrosis | 3 | Pancreatic, Pigmentation | | Renal, Congestion | | Renal, Edema | 4 | Renal, Hyperplasia, Lymphoid | 1 | Renal, Pigmentation | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Ectasia | 2 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Fibrosis | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Fibrosis | 1 2| Hyperplasia, Focal | 2 | Necrosis | 2 | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7| DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2| | 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 3 | Hyperplasia | 1 1 | Duct, Dilatation | 3 2 1 2 3 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X X | Hyperkeratosis | 4| Hyperplasia, Squamous | 2| Necrosis | | Subcutaneous Tissue, Inflammation, | | Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 3 2 | Osteopetrosis | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Infiltration Cellular, Histiocyte | 1 1 1 1 | Inflammation, Chronic | 1 2 2 1 1 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Inflammation, Chronic | | Inflammation, Chronic Active | 1 2 2 3 3 1 3 1 1 3 2 3 3 | Nasolacrimal Duct, Cyst | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Cyst | 3 3 4 2 3 | Nephropathy | 2 4 3 2 2 2 3 2 3 2 3 2 1 4 2 4 1 3 3 3 2 3 3 2 3| Renal Tubule, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PYRIDINE Date: 10/08/97 Route: DOSED WATER Time: 10:52:14 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7| DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2| | 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2| ________________________________________________________________________________________