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TDMS Study 55301-05 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/29/97

EXPERIMENT: 55301 TEST: 05                                                                                     TIME: 09:11:52
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01ES95268                                ROUTE: DOSED WATER                                             NTP C#: 55301B
PATHOLOGIST: P. HILDEBRANDT                                                                                    CAS: 110-86-1
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/29/97     
EXPERIMENT: 55301 TEST: 05                                                                                     TIME: 09:11:52     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01ES95268                                ROUTE: DOSED WATER                                             NTP C#: 55301B     
PATHOLOGIST: P. HILDEBRANDT                                                                                    CAS: 110-86-1      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                     PYRIDINE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hyperplasia
Bone                                   Fibrous Osteodystrophy
Heart                                  Cardiomyopathy
Kidney                                 Cyst
                                       Nephropathy
Kidney: Renal Tubule                   Hyperplasia
Liver                                  Basophilic Focus
                                       Clear Cell Focus
                                       Degeneration Cystic
                                       Eosinophilic Focus
                                       Fibrosis
                                       Hepatodiaphragmatic Nodule
                                       Mitotic Alteration
                                       Pigmentation
                                       Vacuolization Cytoplasmic
Liver: Bile Duct                       Hyperplasia
Liver: Centrilobular                   Cytomegaly
                                       Degeneration
                                       Necrosis
Liver: Periportal                      Fibrosis
Lung                                   Infiltration Cellular Histiocyte
Lymph Node, Mediastinal                Congestion
Lymph Node: Renal                      Pigmentation
Parathyroid Gland                      Hyperplasia
Pituitary Gland: Pars Distalis         Cyst
                                       Hyperplasia
Preputial Gland                        Inflammation Chronic
Spleen                                 Necrosis
                                       Pigmentation
Stomach, Forestomach                   Hyperkeratosis
                                       Inflammation Chronic
                                       Ulcer
Stomach, Forestomach: Epithelium       Hyperplasia
Stomach, Glandular                     Mineralization
Testes: Interstitial Cell              Hyperplasia
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Heart                                  Cardiomyopathy
Kidney                                 Mineralization
Liver                                  Basophilic Focus
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/29/97     
EXPERIMENT: 55301 TEST: 05                                                                                     TIME: 09:11:52     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01ES95268                                ROUTE: DOSED WATER                                             NTP C#: 55301B     
PATHOLOGIST: P. HILDEBRANDT                                                                                    CAS: 110-86-1      

                                       Clear Cell Focus
                                       Hepatodiaphragmatic Nodule
                                       Inflammation Chronic
                                       Necrosis
                                       Pigmentation
                                       Tension Lipidosis
                                       Vacuolization Cytoplasmic
Liver: Bile Duct                       Hyperplasia
Liver: Capsule                         Inflammation Chronic
Liver: Centrilobular                   Cytomegaly
                                       Degeneration
Lymph Node, Mandibular                 Ectasia
Lymph Node: Iliac                      Congestion
Mammary Gland                          Galactocele
Mesentery: Fat                         Necrosis
Pancreas                               Atrophy
Pituitary Gland: Pars Distalis         Angiectasis
                                       Cyst
Uterus                                 Hyperplasia Cystic
===============================================================
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   7/49 (14%)   7/50 (14%)   2/50 (4%)   |11/50 (22%)  12/50 (24%)  9/50 (18%)   6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     19.3%        17.6%        17.0%        5.2%        |24.8%        26.2%        20.3%        14.7%        |
|TERMINAL (d)       |     6/25 (24%)   7/20 (35%)   5/25 (20%)   0/16 (0%)   |11/32 (34%)  11/37 (30%)  8/29 (28%)   6/26 (23%)   |
|FIRST INCIDENCE    |     625          722 (T)      644          681         |729 (T)      728          605          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.111N     P=0.548      P=0.515N     P=0.148N    |P=0.208N     P=0.532N     P=0.495N     P=0.260N     |
|POLY 3             |     P=0.047N*    P=0.538N     P=0.507N     P=0.056N    |P=0.118N     P=0.534      P=0.401N     P=0.186N     |
|POLY 1.5           |     P=0.043N*    P=0.519N     P=0.499N     P=0.051N    |P=0.100N     P=0.520      P=0.400N     P=0.166N     |
|POLY 6             |     P=0.057N     P=0.583N     P=0.529N     P=0.069N    |P=0.147N     P=0.555      P=0.403N     P=0.220N     |
|LOGISTIC REGRESSION|     P=0.071N     P=0.574      P=0.539N     P=0.075N    |P=0.208N     (e)          P=0.429N     P=0.260N     |
|COCH-ARM / FISHERS |     P=0.038N*    P=0.517N     P=0.500N     P=0.046N*   |P=0.081N     P=0.500      P=0.402N     P=0.143N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.4%         0.0%         0.0%         5.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/25 (4%)    0/20 (0%)    0/25 (0%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     722 (T)      ---          ---          717         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.170      P=0.545N     P=0.500N     P=0.350     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.240      P=0.507N     P=0.501N     P=0.475     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.242      P=0.504N     P=0.500N     P=0.487     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.237      P=0.515N     P=0.506N     P=0.453     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.175      (e)          (e)          P=0.356     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.247      P=0.505N     P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   5/49 (10%)   9/50 (18%)   7/50 (14%)  |6/50 (12%)   8/50 (16%)   6/50 (12%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     21.0%        12.4%        21.5%        17.5%       |13.2%        17.2%        13.5%        7.4%         |
|TERMINAL (d)       |     5/25 (20%)   3/20 (15%)   5/25 (20%)   3/16 (19%)  |3/32 (9%)    5/37 (14%)   3/29 (10%)   2/26 (8%)    |
|FIRST INCIDENCE    |     473          620          589          444         |503          611          624          711          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.420      P=0.298N     P=0.595      P=0.580     |P=0.264N     P=0.472      P=0.587      P=0.349N     |
|POLY 3             |     P=0.513N     P=0.225N     P=0.585      P=0.449N    |P=0.195N     P=0.404      P=0.606      P=0.297N     |
|POLY 1.5           |     P=0.493N     P=0.211N     P=0.596      P=0.422N    |P=0.169N     P=0.397      P=0.613      P=0.272N     |
|POLY 6             |     P=0.548N     P=0.256N     P=0.563      P=0.500N    |P=0.235N     P=0.416      P=0.597      P=0.335N     |
|LOGISTIC REGRESSION|     P=0.486N     P=0.204N     P=0.602N     P=0.388N    |P=0.156N     P=0.374      P=0.620N     P=0.257N     |
|COCH-ARM / FISHERS |     P=0.467N     P=0.205N     P=0.602N     P=0.393N    |P=0.139N     P=0.387      P=0.620N     P=0.243N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  23/49 (47%)  19/50 (38%)  16/49 (33%) |5/50 (10%)   7/50 (14%)   8/50 (16%)   2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     42.2%        54.5%        45.4%        40.0%       |11.2%        15.1%        17.4%        5.0%         |
|TERMINAL (d)       |     13/25 (52%)  13/20 (65%)  14/25 (56%)  9/16 (56%)  |4/32 (13%)   3/37 (8%)    3/29 (10%)   0/25 (0%)    |
|FIRST INCIDENCE    |     571          598          627          465         |671          650          521          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.398      P=0.069      P=0.485      P=0.279     |P=0.289N     P=0.461      P=0.255      P=0.320N     |
|POLY 3             |     P=0.321N     P=0.172      P=0.467      P=0.509N    |P=0.222N     P=0.408      P=0.297      P=0.259N     |
|POLY 1.5           |     P=0.290N     P=0.185      P=0.490      P=0.475N    |P=0.198N     P=0.396      P=0.290      P=0.244N     |
|POLY 6             |     P=0.397N     P=0.142      P=0.417      P=0.584N    |P=0.260N     P=0.427      P=0.306      P=0.281N     |
|LOGISTIC REGRESSION|     P=0.388N     P=0.149      P=0.456      P=0.538N    |P=0.142N     P=0.395      P=0.275      P=0.254N     |
|COCH-ARM / FISHERS |     P=0.262N     P=0.184      P=0.500      P=0.445N    |P=0.169N     P=0.380      P=0.277      P=0.226N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    4/50 (8%)    6/50 (12%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.8%         2.5%         9.6%         15.4%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    1/25 (4%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     574          722 (T)      585          622         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.016 *    P=0.557N     P=0.318      P=0.066     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.028 *    P=0.510N     P=0.335      P=0.109     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.031 *    P=0.502N     P=0.338      P=0.120     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.024 *    P=0.529N     P=0.325      P=0.092     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.029 *    P=0.500N     P=0.337      P=0.115     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.036 *    P=0.500N     P=0.339      P=0.134     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |9/50 (18%)   12/50 (24%)  10/50 (20%)  5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     2.4%         0.0%         4.9%         0.0%        |19.6%        25.8%        22.0%        12.0%        |
|TERMINAL (d)       |     1/25 (4%)    0/20 (0%)    2/25 (8%)    0/16 (0%)   |5/32 (16%)   10/37 (27%)  4/29 (14%)   2/26 (8%)    |
|FIRST INCIDENCE    |     722 (T)      ---          722 (T)      ---         |493          546          580          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.554N     P=0.545N     P=0.500      P=0.589N    |P=0.249N     P=0.420      P=0.445      P=0.318N     |
|POLY 3             |     P=0.482N     P=0.503N     P=0.498      P=0.514N    |P=0.158N     P=0.325      P=0.490      P=0.245N     |
|POLY 1.5           |     P=0.473N     P=0.500N     P=0.501      P=0.507N    |P=0.134N     P=0.320      P=0.495      P=0.222N     |
|POLY 6             |     P=0.495N     P=0.512N     P=0.489      P=0.527N    |P=0.196N     P=0.331      P=0.484      P=0.280N     |
|LOGISTIC REGRESSION|     P=0.554N     (e)          P=0.500      (e)         |P=0.100N     P=0.305      P=0.502      P=0.172N     |
|COCH-ARM / FISHERS |     P=0.461N     P=0.500N     P=0.500      P=0.500N    |P=0.107N     P=0.312      P=0.500      P=0.194N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Depletion Cellular                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.8%         9.7%         7.1%         2.6%        |2.3%         0.0%         4.6%         4.8%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    1/25 (4%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     644          665          269          722 (T)     |717          ---          707          589          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.384N     P=0.275      P=0.488      P=0.616N    |P=0.185      P=0.478N     P=0.471      P=0.441      |
|POLY 3             |     P=0.329N     P=0.333      P=0.508      P=0.528N    |P=0.219      P=0.494N     P=0.497      P=0.476      |
|POLY 1.5           |     P=0.311N     P=0.340      P=0.509      P=0.515N    |P=0.231      P=0.496N     P=0.499      P=0.487      |
|POLY 6             |     P=0.363N     P=0.316      P=0.498      P=0.553N    |P=0.204      P=0.491N     P=0.493      P=0.462      |
|LOGISTIC REGRESSION|     P=0.274N     P=0.336      P=0.475      P=0.530N    |P=0.267      P=0.491N     P=0.491      P=0.542      |
|COCH-ARM / FISHERS |     P=0.292N     P=0.339      P=0.500      P=0.500N    |P=0.245      P=0.500N     P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    4/50 (8%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |6.7%         8.4%         0.0%         2.5%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |1/32 (3%)    0/37 (0%)    0/29 (0%)    1/26 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |687          488          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.152N     P=0.535      P=0.123N     P=0.388N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.124N     P=0.534      P=0.122N     P=0.339N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.520      P=0.120N     P=0.324N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.133N     P=0.551      P=0.124N     P=0.362N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.078N     P=0.417      P=0.122N     P=0.352N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.500      P=0.121N     P=0.309N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/48 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         0.0%        |2.2%         2.2%         0.0%         4.8%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/23 (0%)    0/16 (0%)   |0/32 (0%)    1/37 (3%)    0/29 (0%)    1/26 (4%)    |
|FIRST INCIDENCE    |     ---          ---          525          ---         |681          729 (T)      ---          503          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.691      (e)          P=0.513      (e)         |P=0.308      P=0.736N     P=0.495N     P=0.449      |
|POLY 3             |     P=0.661      (e)          P=0.492      (e)         |P=0.348      P=0.755N     P=0.503N     P=0.474      |
|POLY 1.5           |     P=0.675      (e)          P=0.493      (e)         |P=0.357      P=0.757N     P=0.501N     P=0.486      |
|POLY 6             |     P=0.637      (e)          P=0.487      (e)         |P=0.337      P=0.752N     P=0.506N     P=0.456      |
|LOGISTIC REGRESSION|     P=0.727      (e)          P=0.477      (e)         |P=0.409      P=0.760N     P=0.500N     P=0.550      |
|COCH-ARM / FISHERS |     P=0.693      (e)          P=0.490      (e)         |P=0.366      P=0.753N     P=0.500N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/47 (2%)    2/48 (4%)    1/50 (2%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.4%         4.5%         2.3%         5.0%         |
|TERMINAL (d)       |                                                        |1/32 (3%)    2/36 (6%)    1/29 (3%)    2/25 (8%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.333      P=0.541      P=0.740      P=0.414      |
|POLY 3             |                                                        |P=0.420      P=0.519      P=0.750N     P=0.481      |
|POLY 1.5           |                                                        |P=0.438      P=0.515      P=0.748N     P=0.497      |
|POLY 6             |                                                        |P=0.393      P=0.525      P=0.754N     P=0.459      |
|LOGISTIC REGRESSION|                                                        |P=0.333      P=0.541      P=0.740      P=0.414      |
|COCH-ARM / FISHERS |                                                        |P=0.460      P=0.508      P=0.737N     P=0.516      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/47 (2%)    2/48 (4%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.4%         4.5%         2.3%         0.0%         |
|TERMINAL (d)       |                                                        |1/32 (3%)    1/36 (3%)    1/29 (3%)    0/25 (0%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      728          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.313N     P=0.547      P=0.740      P=0.549N     |
|POLY 3             |                                                        |P=0.261N     P=0.520      P=0.750N     P=0.511N     |
|POLY 1.5           |                                                        |P=0.250N     P=0.515      P=0.748N     P=0.502N     |
|POLY 6             |                                                        |P=0.277N     P=0.525      P=0.754N     P=0.524N     |
|LOGISTIC REGRESSION|                                                        |P=0.317N     P=0.540      P=0.740      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.237N     P=0.508      P=0.737N     P=0.490N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/47 (9%)    2/48 (4%)    7/50 (14%)   3/49 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |9.6%         4.5%         15.9%        7.3%         |
|TERMINAL (d)       |                                                        |4/32 (13%)   2/36 (6%)    5/29 (17%)   0/25 (0%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      707          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.408      P=0.283N     P=0.213      P=0.600N     |
|POLY 3             |                                                        |P=0.533      P=0.311N     P=0.289      P=0.513N     |
|POLY 1.5           |                                                        |P=0.561      P=0.318N     P=0.295      P=0.497N     |
|POLY 6             |                                                        |P=0.491      P=0.304N     P=0.279      P=0.538N     |
|LOGISTIC REGRESSION|                                                        |P=0.544      P=0.283N     P=0.246      P=0.464N     |
|COCH-ARM / FISHERS |                                                        |P=0.544N     P=0.329N     P=0.299      P=0.476N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland: Duct                                                                                                             |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/47 (6%)    5/48 (10%)   4/50 (8%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |7.1%         11.3%        9.1%         5.0%         |
|TERMINAL (d)       |                                                        |1/32 (3%)    5/36 (14%)   3/29 (10%)   2/25 (8%)    |
|FIRST INCIDENCE    |                                                        |671          729 (T)      707          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.474N     P=0.414      P=0.470      P=0.607N     |
|POLY 3             |                                                        |P=0.361N     P=0.382      P=0.522      P=0.529N     |
|POLY 1.5           |                                                        |P=0.332N     P=0.377      P=0.528      P=0.507N     |
|POLY 6             |                                                        |P=0.407N     P=0.385      P=0.509      P=0.562N     |
|LOGISTIC REGRESSION|                                                        |P=0.417N     P=0.390      P=0.523      P=0.541N     |
|COCH-ARM / FISHERS |                                                        |P=0.298N     P=0.369      P=0.535      P=0.480N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    2/49 (4%)    0/48 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.9%         0.0%        |                                                    |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |                                                    |
|FIRST INCIDENCE    |     ---          ---          679          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.537      (e)          P=0.222      (e)         |                                                    |
|POLY 3             |     P=0.552      (e)          P=0.238      (e)         |                                                    |
|POLY 1.5           |     P=0.569      (e)          P=0.239      (e)         |                                                    |
|POLY 6             |     P=0.522      (e)          P=0.235      (e)         |                                                    |
|LOGISTIC REGRESSION|     P=0.577      (e)          P=0.237      (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.591      (e)          P=0.247      (e)         |                                                    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     1/1 (100%)   2/2 (100%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         100.0%       100.0%       |
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     1/1 (100%)   2/2 (100%)   |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     45/50 (90%)  43/50 (86%)  43/50 (86%)  46/50 (92%) |42/49 (86%)  43/50 (86%)  43/50 (86%)  36/50 (72%)  |
|POLY-3 ADJUSTED (b)|     92.3%        88.5%        90.4%        96.6%       |89.8%        88.7%        87.2%        78.3%        |
|TERMINAL (d)       |     25/25 (100%) 17/20 (85%)  23/25 (92%)  16/16 (100%)|28/31 (90%)  34/37 (92%)  24/29 (83%)  21/26 (81%)  |
|FIRST INCIDENCE    |     309          444          269          428         |493          533          496          503          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.044 *    P=0.308      P=0.478N     P=0.032 *   |P=0.343      P=0.220N     P=0.372      P=0.509      |
|POLY 3             |     P=0.175      P=0.374N     P=0.511N     P=0.294     |P=0.051N     P=0.569N     P=0.467N     P=0.091N     |
|POLY 1.5           |     P=0.210      P=0.377N     P=0.457N     P=0.329     |P=0.041N*    P=0.587N     P=0.531N     P=0.079N     |
|POLY 6             |     P=0.180      P=0.369N     P=0.557N     P=0.323     |P=0.073N     P=0.565N     P=0.397N     P=0.122N     |
|LOGISTIC REGRESSION|     P=0.306      P=0.377N     P=0.365N     P=0.445     |P=0.083N     P=0.534N     P=0.604      P=0.148N     |
|COCH-ARM / FISHERS |     P=0.368      P=0.380N     P=0.380N     P=0.500     |P=0.034N*    P=0.597      P=0.597      P=0.077N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    2/50 (4%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.4%         0.0%         7.2%         5.2%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/31 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     574          ---          585          685         |503          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.186      P=0.496N     P=0.293      P=0.412     |P=0.306N     P=0.496N     P=0.496N     P=0.500N     |
|POLY 3             |     P=0.213      P=0.505N     P=0.304      P=0.472     |P=0.296N     P=0.492N     P=0.501N     P=0.516N     |
|POLY 1.5           |     P=0.225      P=0.501N     P=0.307      P=0.485     |P=0.299N     P=0.494N     P=0.498N     P=0.507N     |
|POLY 6             |     P=0.195      P=0.516N     P=0.297      P=0.449     |P=0.290N     P=0.490N     P=0.504N     P=0.528N     |
|LOGISTIC REGRESSION|     P=0.243      P=0.545N     P=0.300      P=0.498     |P=0.239N     P=0.681N     P=0.652N     P=0.423N     |
|COCH-ARM / FISHERS |     P=0.242      P=0.500N     P=0.309      P=0.500     |P=0.303N     P=0.495N     P=0.495N     P=0.495N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   3/50 (6%)    4/50 (8%)   |0/49 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.9%         14.4%        7.3%         10.2%       |0.0%         0.0%         4.5%         2.4%         |
|TERMINAL (d)       |     2/25 (8%)    0/20 (0%)    2/25 (8%)    0/16 (0%)   |0/31 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     722 (T)      618          700          601         |---          ---          561          672          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.311      P=0.102      P=0.494      P=0.215     |P=0.209      (e)          P=0.249      P=0.461      |
|POLY 3             |     P=0.411      P=0.136      P=0.498      P=0.314     |P=0.214      (e)          P=0.243      P=0.488      |
|POLY 1.5           |     P=0.427      P=0.138      P=0.501      P=0.325     |P=0.229      (e)          P=0.243      P=0.495      |
|POLY 6             |     P=0.382      P=0.128      P=0.488      P=0.294     |P=0.194      (e)          P=0.243      P=0.479      |
|LOGISTIC REGRESSION|     P=0.411      P=0.132      P=0.461      P=0.311     |P=0.298      (e)          P=0.222      P=0.512      |
|COCH-ARM / FISHERS |     P=0.446      P=0.134      P=0.500      P=0.339     |P=0.249      (e)          P=0.253      P=0.505      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    4/48 (8%)    3/50 (6%)    2/49 (4%)   |3/50 (6%)    3/50 (6%)    3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     9.7%         10.1%        7.3%         5.3%        |6.7%         6.6%         6.8%         2.5%         |
|TERMINAL (d)       |     2/25 (8%)    2/20 (10%)   3/25 (12%)   1/16 (6%)   |2/32 (6%)    3/37 (8%)    3/29 (10%)   1/26 (4%)    |
|FIRST INCIDENCE    |     718          604          722 (T)      598         |667          729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.364N     P=0.546      P=0.511N     P=0.518N    |P=0.318N     P=0.605N     P=0.622      P=0.386N     |
|POLY 3             |     P=0.263N     P=0.625      P=0.504N     P=0.376N    |P=0.261N     P=0.651N     P=0.655      P=0.338N     |
|POLY 1.5           |     P=0.252N     P=0.628      P=0.499N     P=0.362N    |P=0.244N     P=0.655N     P=0.659      P=0.323N     |
|POLY 6             |     P=0.284N     P=0.611      P=0.518N     P=0.403N    |P=0.287N     P=0.645N     P=0.649      P=0.361N     |
|LOGISTIC REGRESSION|     P=0.280N     P=0.606      P=0.552N     P=0.415N    |P=0.303N     P=0.640N     P=0.652      P=0.360N     |
|COCH-ARM / FISHERS |     P=0.236N     P=0.619      P=0.500N     P=0.349N    |P=0.221N     P=0.661N     P=0.661N     P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    2/48 (4%)    0/50 (0%)    1/49 (2%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     9.6%         5.1%         0.0%         2.6%        |2.2%         4.4%         2.3%         4.9%         |
|TERMINAL (d)       |     2/25 (8%)    1/20 (5%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    2/37 (5%)    0/29 (0%)    2/26 (8%)    |
|FIRST INCIDENCE    |     604          718          ---          515         |493          729 (T)      703          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.122N     P=0.411N     P=0.067N     P=0.249N    |P=0.361      P=0.534      P=0.758N     P=0.450      |
|POLY 3             |     P=0.089N     P=0.370N     P=0.063N     P=0.206N    |P=0.403      P=0.505      P=0.755      P=0.465      |
|POLY 1.5           |     P=0.088N     P=0.359N     P=0.061N     P=0.196N    |P=0.421      P=0.503      P=0.758      P=0.480      |
|POLY 6             |     P=0.091N     P=0.396N     P=0.067N     P=0.228N    |P=0.378      P=0.509      P=0.752      P=0.443      |
|LOGISTIC REGRESSION|     P=0.087N     P=0.362N     P=0.063N     P=0.179N    |P=0.454      P=0.455      P=0.738      P=0.538      |
|COCH-ARM / FISHERS |     P=0.087N     P=0.359N     P=0.059N     P=0.187N    |P=0.444      P=0.500      P=0.753N     P=0.500      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Ileum                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   9/47 (19%)   3/50 (6%)    4/47 (9%)   |3/50 (6%)    2/49 (4%)    2/50 (4%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     14.3%        23.1%        7.3%         10.8%       |6.8%         4.4%         4.6%         12.2%        |
|TERMINAL (d)       |     5/25 (20%)   8/20 (40%)   3/25 (12%)   2/16 (13%)  |3/32 (9%)    2/37 (5%)    2/29 (7%)    4/26 (15%)   |
|FIRST INCIDENCE    |     473          538          722 (T)      444         |729 (T)      729 (T)      729 (T)      634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.311N     P=0.155      P=0.234N     P=0.574N    |P=0.114      P=0.434N     P=0.545N     P=0.250      |
|POLY 3             |     P=0.199N     P=0.232      P=0.252N     P=0.445N    |P=0.183      P=0.492N     P=0.505N     P=0.314      |
|POLY 1.5           |     P=0.189N     P=0.243      P=0.245N     P=0.428N    |P=0.196      P=0.499N     P=0.502N     P=0.333      |
|POLY 6             |     P=0.220N     P=0.205      P=0.266N     P=0.476N    |P=0.165      P=0.481N     P=0.510N     P=0.288      |
|LOGISTIC REGRESSION|     P=0.203N     P=0.230      P=0.248N     P=0.408N    |P=0.127      P=0.434N     P=0.545N     P=0.260      |
|COCH-ARM / FISHERS |     P=0.178N     P=0.245      P=0.243N     P=0.410N    |P=0.213      P=0.510N     P=0.500N     P=0.357      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/48 (4%)    1/50 (2%)    1/49 (2%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     11.9%        5.1%         2.4%         2.7%        |0.0%         0.0%         2.3%         2.4%         |
|TERMINAL (d)       |     2/25 (8%)    2/20 (10%)   0/25 (0%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     574          722 (T)      662          722 (T)     |---          ---          729 (T)      641          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.098N     P=0.290N     P=0.115N     P=0.195N    |P=0.187      (e)          P=0.480      P=0.453      |
|POLY 3             |     P=0.065N     P=0.245N     P=0.106N     P=0.130N    |P=0.213      (e)          P=0.501      P=0.487      |
|POLY 1.5           |     P=0.063N     P=0.236N     P=0.103N     P=0.118N    |P=0.224      (e)          P=0.503      P=0.495      |
|POLY 6             |     P=0.069N     P=0.268N     P=0.113N     P=0.152N    |P=0.198      (e)          P=0.498      P=0.477      |
|LOGISTIC REGRESSION|     P=0.067N     P=0.233N     P=0.103N     P=0.115N    |P=0.242      (e)          P=0.480      P=0.532      |
|COCH-ARM / FISHERS |     P=0.061N     P=0.235N     P=0.102N     P=0.107N    |P=0.238      (e)          P=0.505      P=0.505      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |596          ---          703          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.217N     P=0.231N     P=0.505N     P=0.273N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.200N     P=0.233N     P=0.508N     P=0.260N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.195N     P=0.235N     P=0.504N     P=0.250N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.207N     P=0.232N     P=0.514N     P=0.276N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.166N     P=0.269N     P=0.505N     P=0.205N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.188N     P=0.247N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/48 (6%)    13/50 (26%)  10/49 (20%) |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.3%         7.6%         30.7%        26.2%       |0.0%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |     3/25 (12%)   2/20 (10%)   8/25 (32%)   3/16 (19%)  |0/32 (0%)    0/37 (0%)    1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     722 (T)      665          534          622         |---          ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.573      P=0.007 **   P=0.007 **  |P=0.665      (e)          P=0.480      (e)          |
|POLY 3             |     P=0.004 **   P=0.643      P=0.006 **   P=0.022 *   |P=0.653      (e)          P=0.498      (e)          |
|POLY 1.5           |     P=0.005 **   P=0.647      P=0.006 **   P=0.026 *   |P=0.671      (e)          P=0.499      (e)          |
|POLY 6             |     P=0.003 **   P=0.628      P=0.005 **   P=0.016 *   |P=0.625      (e)          P=0.496      (e)          |
|LOGISTIC REGRESSION|     P=0.003 **   P=0.584      P=0.006 **   P=0.012 *   |(e)          (e)          P=0.480      (e)          |
|COCH-ARM / FISHERS |     P=0.009 **   P=0.641      P=0.006 **   P=0.033 *   |P=0.694      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Developmental Malformation                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/25 (8%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     722 (T)      ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.140N     P=0.288N     P=0.237N     P=0.340N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.111N     P=0.248N     P=0.238N     P=0.259N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.113N     P=0.245N     P=0.237N     P=0.250N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.106N     P=0.256N     P=0.243N     P=0.274N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.140N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.116N     P=0.258N     P=0.247N     P=0.253N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/48 (2%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.3%         2.6%         0.0%         5.2%        |0.0%         4.3%         0.0%         0.0%         |
|TERMINAL (d)       |     2/25 (8%)    1/20 (5%)    0/25 (0%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     692          722 (T)      ---          194         |---          488          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.552N     P=0.393N     P=0.130N     P=0.654N    |P=0.410N     P=0.242      (e)          (e)          |
|POLY 3             |     P=0.450N     P=0.323N     P=0.120N     P=0.534N    |P=0.412N     P=0.250      (e)          (e)          |
|POLY 1.5           |     P=0.449N     P=0.318N     P=0.118N     P=0.519N    |P=0.408N     P=0.245      (e)          (e)          |
|POLY 6             |     P=0.451N     P=0.338N     P=0.124N     P=0.562N    |P=0.418N     P=0.257      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.424N     P=0.373N     P=0.130N     P=0.482N    |P=0.295N     P=0.095      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.447N     P=0.324N     P=0.121N     P=0.510N    |P=0.405N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |3/50 (6%)    0/50 (0%)    4/50 (8%)    6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |6.6%         0.0%         9.0%         14.3%        |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |1/32 (3%)    0/37 (0%)    2/29 (7%)    3/26 (12%)   |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |493          ---          561          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.030 *    P=0.111N     P=0.478      P=0.181      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.042 *    P=0.117N     P=0.491      P=0.207      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.047 *    P=0.118N     P=0.496      P=0.222      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.036 *    P=0.115N     P=0.484      P=0.187      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.082      P=0.144N     P=0.497      P=0.295      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.055      P=0.121N     P=0.500      P=0.243      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     47/50 (94%)  47/48 (98%)  49/50 (98%)  49/49 (100%)|41/50 (82%)  42/50 (84%)  35/50 (70%)  37/50 (74%)  |
|POLY-3 ADJUSTED (b)|     95.2%        98.7%        98.7%        100.0%      |83.7%        87.6%        73.8%        80.0%        |
|TERMINAL (d)       |     25/25 (100%) 20/20 (100%) 25/25 (100%) 16/16 (100%)|28/32 (88%)  35/37 (95%)  22/29 (76%)  22/26 (85%)  |
|FIRST INCIDENCE    |     309          444          269          194         |399          533          549          457          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.029 *    P=0.195      P=0.407      P=0.027 *   |P=0.246      P=0.276N     P=0.356N     P=0.348      |
|POLY 3             |     P=0.080      P=0.331      P=0.322      P=0.163     |P=0.226N     P=0.391      P=0.164N     P=0.416N     |
|POLY 1.5           |     P=0.076      P=0.324      P=0.313      P=0.141     |P=0.177N     P=0.437      P=0.146N     P=0.336N     |
|POLY 6             |     P=0.096      P=0.352      P=0.347      P=0.218     |P=0.292N     P=0.337      P=0.185N     P=0.518N     |
|LOGISTIC REGRESSION|     P=0.071      P=0.324      P=0.306      P=0.126     |P=0.209N     P=0.547      P=0.121N     P=0.297N     |
|COCH-ARM / FISHERS |     P=0.074      P=0.324      P=0.309      P=0.125     |P=0.120N     P=0.500      P=0.121N     P=0.235N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    0/50 (0%)    1/49 (2%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.6%        |0.0%         0.0%         4.6%         2.5%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    1/29 (3%)    1/26 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          444         |---          ---          707          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.199      (e)          (e)          P=0.508     |P=0.184      (e)          P=0.226      P=0.459      |
|POLY 3             |     P=0.191      (e)          (e)          P=0.485     |P=0.209      (e)          P=0.235      P=0.483      |
|POLY 1.5           |     P=0.194      (e)          (e)          P=0.490     |P=0.225      (e)          P=0.236      P=0.490      |
|POLY 6             |     P=0.186      (e)          (e)          P=0.474     |P=0.187      (e)          P=0.233      P=0.472      |
|LOGISTIC REGRESSION|     P=0.272      (e)          (e)          P=0.555     |P=0.192      (e)          P=0.232      P=0.459      |
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.495     |P=0.246      (e)          P=0.247      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/48 (0%)    4/50 (8%)    7/49 (14%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.4%         0.0%         9.7%         18.4%       |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     1/25 (4%)    0/20 (0%)    3/25 (12%)   2/16 (13%)  |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     722 (T)      ---          648          644         |---          ---          ---          503          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.545N     P=0.178      P=0.012 *   |P=0.197      (e)          (e)          P=0.500      |
|POLY 3             |     P<0.001 **   P=0.510N     P=0.177      P=0.021 *   |P=0.188      (e)          (e)          P=0.486      |
|POLY 1.5           |     P=0.002 **   P=0.507N     P=0.180      P=0.024 *   |P=0.193      (e)          (e)          P=0.492      |
|POLY 6             |     P<0.001 **   P=0.518N     P=0.171      P=0.017 *   |P=0.181      (e)          (e)          P=0.477      |
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.164      P=0.018 *   |P=0.299      (e)          (e)          P=0.576      |
|COCH-ARM / FISHERS |     P=0.002 **   P=0.510N     P=0.181      P=0.028 *   |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    2/50 (4%)    3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         2.4%         2.6%        |4.5%         4.4%         6.8%         4.9%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |1/32 (3%)    1/37 (3%)    2/29 (7%)    1/26 (4%)    |
|FIRST INCIDENCE    |     ---          708          679          717         |717          728          671          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.311      P=0.438      P=0.481      P=0.416     |P=0.457      P=0.641N     P=0.463      P=0.624      |
|POLY 3             |     P=0.359      P=0.494      P=0.500      P=0.486     |P=0.520      P=0.683N     P=0.497      P=0.667      |
|POLY 1.5           |     P=0.372      P=0.497      P=0.501      P=0.493     |P=0.541      P=0.687N     P=0.499      P=0.679      |
|POLY 6             |     P=0.336      P=0.485      P=0.496      P=0.473     |P=0.490      P=0.677N     P=0.494      P=0.649      |
|LOGISTIC REGRESSION|     P=0.350      P=0.474      P=0.500      P=0.434     |P=0.529      P=0.662N     P=0.491      P=0.687      |
|COCH-ARM / FISHERS |     P=0.386      P=0.495      P=0.500      P=0.500     |P=0.569      P=0.691N     P=0.500      P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  5/49 (10%)   0/50 (0%)    1/50 (2%)   |38/50 (76%)  28/50 (56%)  11/50 (22%)  0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     29.0%        12.6%        0.0%         2.6%        |81.3%        60.9%        25.1%        0.0%         |
|TERMINAL (d)       |     11/25 (44%)  5/20 (25%)   0/25 (0%)    1/16 (6%)   |30/32 (94%)  26/37 (70%)  11/29 (38%)  0/26 (0%)    |
|FIRST INCIDENCE    |     644          722 (T)      ---          722 (T)     |493          666          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.107N     P<0.001N**   P=0.008N**  |P<0.001N**   P=0.002N**   P<0.001N**   P<0.001N**   |
|POLY 3             |     P<0.001N**   P=0.057N     P<0.001N**   P<0.001N**  |P<0.001N**   P=0.019N*    P<0.001N**   P<0.001N**   |
|POLY 1.5           |     P<0.001N**   P=0.055N     P<0.001N**   P<0.001N**  |P<0.001N**   P=0.021N*    P<0.001N**   P<0.001N**   |
|POLY 6             |     P<0.001N**   P=0.068N     P<0.001N**   P=0.002N**  |P<0.001N**   P=0.017N*    P<0.001N**   P<0.001N**   |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.120N     P<0.001N**   P=0.005N**  |P<0.001N**   P=0.009N**   P<0.001N**   P<0.001N**   |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.059N     P<0.001N**   P<0.001N**  |P<0.001N**   P=0.028N*    P<0.001N**   P<0.001N**   |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   1/49 (2%)    7/50 (14%)   4/50 (8%)   |4/50 (8%)    9/50 (18%)   11/50 (22%)  16/50 (32%)  |
|POLY-3 ADJUSTED (b)|     17.0%        2.5%         17.1%        10.3%       |9.0%         19.7%        25.1%        39.3%        |
|TERMINAL (d)       |     7/25 (28%)   1/20 (5%)    7/25 (28%)   3/16 (19%)  |4/32 (13%)   9/37 (24%)   11/29 (38%)  16/26 (62%)  |
|FIRST INCIDENCE    |     722 (T)      722 (T)      722 (T)      562         |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.482      P=0.055N     P=0.622      P=0.532N    |P<0.001 **   P=0.174      P=0.023 *    P<0.001 **   |
|POLY 3             |     P=0.447N     P=0.032N*    P=0.610      P=0.292N    |P<0.001 **   P=0.126      P=0.040 *    P<0.001 **   |
|POLY 1.5           |     P=0.435N     P=0.031N*    P=0.613N     P=0.277N    |P<0.001 **   P=0.122      P=0.042 *    P<0.001 **   |
|POLY 6             |     P=0.468N     P=0.036N*    P=0.593      P=0.324N    |P<0.001 **   P=0.132      P=0.036 *    P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.566      P=0.055N     P=0.622      P=0.379N    |P<0.001 **   P=0.174      P=0.023 *    P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.415N     P=0.032N*    P=0.613N     P=0.262N    |P=0.002 **   P=0.117      P=0.045 *    P=0.003 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |4/50 (8%)    1/50 (2%)    3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.4%         0.0%         0.0%         0.0%        |8.8%         2.2%         6.7%         4.8%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     434          ---          ---          ---         |588          728          624          457          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.304N     P=0.488N     P=0.492N     P=0.496N    |P=0.445N     P=0.164N     P=0.521N     P=0.388N     |
|POLY 3             |     P=0.294N     P=0.510N     P=0.505N     P=0.518N    |P=0.403N     P=0.177N     P=0.511N     P=0.373N     |
|POLY 1.5           |     P=0.300N     P=0.506N     P=0.502N     P=0.510N    |P=0.389N     P=0.177N     P=0.505N     P=0.356N     |
|POLY 6             |     P=0.284N     P=0.520N     P=0.511N     P=0.532N    |P=0.425N     P=0.176N     P=0.519N     P=0.401N     |
|LOGISTIC REGRESSION|     P=0.233N     P=0.733N     P=0.529N     P=0.439N    |P=0.250N     P=0.203N     P=0.507N     P=0.215N     |
|COCH-ARM / FISHERS |     P=0.305N     P=0.505N     P=0.500N     P=0.500N    |P=0.371N     P=0.181N     P=0.500N     P=0.339N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    12/49 (24%)  11/50 (22%)  3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.6%         29.4%        26.0%        7.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/25 (8%)    7/20 (35%)   7/25 (28%)   1/16 (6%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     574          604          525          520         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.435N     P=0.012 *    P=0.049 *    P=0.645N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.275N     P=0.020 *    P=0.044 *    P=0.534N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.249N     P=0.022 *    P=0.045 *    P=0.517N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.330N     P=0.015 *    P=0.040 *    P=0.564N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.262N     P=0.020 *    P=0.046 *    P=0.501N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.226N     P=0.024 *    P=0.045 *    P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Developmental Malformation                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.4%         2.6%        |2.2%         4.4%         2.3%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    1/25 (4%)    0/16 (0%)   |0/32 (0%)    2/37 (5%)    1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          722 (T)      428         |696          729 (T)      729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.204      (e)          P=0.500      P=0.508     |P=0.306N     P=0.543      P=0.756      P=0.550N     |
|POLY 3             |     P=0.224      (e)          P=0.499      P=0.490     |P=0.270N     P=0.510      P=0.758      P=0.518N     |
|POLY 1.5           |     P=0.230      (e)          P=0.500      P=0.495     |P=0.260N     P=0.506      P=0.759      P=0.510N     |
|POLY 6             |     P=0.212      (e)          P=0.494      P=0.479     |P=0.286N     P=0.515      P=0.755      P=0.529N     |
|LOGISTIC REGRESSION|     P=0.270      (e)          P=0.500      P=0.563     |P=0.292N     P=0.517      P=0.759      P=0.511N     |
|COCH-ARM / FISHERS |     P=0.237      (e)          P=0.500      P=0.500     |P=0.247N     P=0.500      P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  23/49 (47%)  23/50 (46%)  13/50 (26%) |19/50 (38%)  24/50 (48%)  22/50 (44%)  15/50 (30%)  |
|POLY-3 ADJUSTED (b)|     33.6%        54.8%        52.5%        31.7%       |41.0%        51.9%        49.9%        36.3%        |
|TERMINAL (d)       |     13/25 (52%)  15/20 (75%)  15/25 (60%)  5/16 (31%)  |13/32 (41%)  22/37 (60%)  21/29 (72%)  12/26 (46%)  |
|FIRST INCIDENCE    |     574          455          525          428         |588          666          671          649          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.369      P=0.005 **   P=0.042 *    P=0.288     |P=0.512N     P=0.393      P=0.211      P=0.539N     |
|POLY 3             |     P=0.283N     P=0.035 *    P=0.055      P=0.518N    |P=0.289N     P=0.196      P=0.259      P=0.407N     |
|POLY 1.5           |     P=0.277N     P=0.040 *    P=0.052      P=0.508N    |P=0.213N     P=0.204      P=0.299      P=0.338N     |
|POLY 6             |     P=0.304N     P=0.025 *    P=0.057      P=0.546N    |P=0.422N     P=0.185      P=0.201      P=0.513N     |
|LOGISTIC REGRESSION|     P=0.368N     P=0.021 *    P=0.039 *    P=0.582N    |P=0.373N     P=0.247      P=0.307      P=0.407N     |
|COCH-ARM / FISHERS |     P=0.275N     P=0.041 *    P=0.048 *    P=0.500N    |P=0.142N     P=0.210      P=0.342      P=0.263N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    1/50 (2%)    10/50 (20%) |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         2.4%         24.7%       |2.2%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    0/25 (0%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     574          722 (T)      679          523         |681          570          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.738      P=0.750      P=0.003 **  |P=0.254N     P=0.752N     P=0.495N     P=0.547N     |
|POLY 3             |     P<0.001 **   P=0.751      P=0.758      P=0.003 **  |P=0.241N     P=0.752N     P=0.503N     P=0.518N     |
|POLY 1.5           |     P<0.001 **   P=0.755      P=0.760      P=0.003 **  |P=0.239N     P=0.755N     P=0.501N     P=0.510N     |
|POLY 6             |     P<0.001 **   P=0.740      P=0.752      P=0.002 **  |P=0.243N     P=0.748N     P=0.506N     P=0.530N     |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.755      P=0.759      P=0.005 **  |P=0.199N     P=0.722      P=0.500N     P=0.499N     |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.747      P=0.753N     P=0.004 **  |P=0.236N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.9%         2.5%         0.0%         0.0%        |0.0%         2.2%         2.3%         4.9%         |
|TERMINAL (d)       |     2/25 (8%)    1/20 (5%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    2/26 (8%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      ---          ---         |---          488          707          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.131N     P=0.579N     P=0.237N     P=0.340N    |P=0.112      P=0.504      P=0.494      P=0.193      |
|POLY 3             |     P=0.101N     P=0.512N     P=0.238N     P=0.253N    |P=0.133      P=0.509      P=0.498      P=0.218      |
|POLY 1.5           |     P=0.101N     P=0.506N     P=0.237N     P=0.245N    |P=0.142      P=0.506      P=0.499      P=0.227      |
|POLY 6             |     P=0.101N     P=0.527N     P=0.243N     P=0.268N    |P=0.121      P=0.514      P=0.497      P=0.207      |
|LOGISTIC REGRESSION|     P=0.131N     P=0.579N     (e)          (e)         |P=0.180      P=0.289      P=0.498      P=0.193      |
|COCH-ARM / FISHERS |     P=0.100N     P=0.508N     P=0.247N     P=0.247N    |P=0.153      P=0.500      P=0.500      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |9/50 (18%)   8/50 (16%)   3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     7.3%         2.5%         0.0%         0.0%        |19.7%        16.8%        6.8%         7.3%         |
|TERMINAL (d)       |     2/25 (8%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |6/32 (19%)   4/37 (11%)   3/29 (10%)   2/26 (8%)    |
|FIRST INCIDENCE    |     695          708          ---          ---         |399          533          729 (T)      584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.066N     P=0.400N     P=0.128N     P=0.206N    |P=0.054N     P=0.415N     P=0.083N     P=0.119N     |
|POLY 3             |     P=0.043N*    P=0.317N     P=0.120N     P=0.132N    |P=0.034N*    P=0.462N     P=0.067N     P=0.084N     |
|POLY 1.5           |     P=0.043N*    P=0.312N     P=0.118N     P=0.125N    |P=0.029N*    P=0.478N     P=0.064N     P=0.073N     |
|POLY 6             |     P=0.043N*    P=0.333N     P=0.124N     P=0.145N    |P=0.043N*    P=0.438N     P=0.072N     P=0.102N     |
|LOGISTIC REGRESSION|     P=0.055N     P=0.361N     P=0.130N     P=0.166N    |P=0.017N*    P=0.560N     P=0.062N     P=0.058N     |
|COCH-ARM / FISHERS |     P=0.044N*    P=0.316N     P=0.121N     P=0.121N    |P=0.024N*    P=0.500N     P=0.061N     P=0.061N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |9/50 (18%)   1/50 (2%)    2/50 (4%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |19.6%        2.2%         4.6%         9.8%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |6/32 (19%)   1/37 (3%)    2/29 (7%)    3/26 (12%)   |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |399          729 (T)      729 (T)      673          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.240N     P=0.007N**   P=0.040N*    P=0.211N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.161N     P=0.008N**   P=0.030N*    P=0.163N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.152N     P=0.008N**   P=0.028N*    P=0.142N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.173N     P=0.008N**   P=0.032N*    P=0.195N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.148N     P=0.011N*    P=0.027N*    P=0.118N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.145N     P=0.008N**   P=0.026N*    P=0.117N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mitotic Alteration                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         5.2%        |2.3%         0.0%         0.0%         2.5%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    2/16 (13%)  |1/32 (3%)    0/37 (0%)    0/29 (0%)    1/26 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          722 (T)     |729 (T)      ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.024 *    (e)          (e)          P=0.145     |P=0.542      P=0.471N     P=0.520N     P=0.715      |
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.221     |P=0.577      P=0.494N     P=0.502N     P=0.741      |
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.229     |P=0.585      P=0.496N     P=0.501N     P=0.750      |
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.207     |P=0.567      P=0.490N     P=0.504N     P=0.728      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.145     |P=0.542      (e)          (e)          P=0.715      |
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.247     |P=0.595      P=0.500N     P=0.500N     P=0.753N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    3/50 (6%)    1/50 (2%)   |2/50 (4%)    4/50 (8%)    1/50 (2%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     4.9%         2.5%         7.3%         2.6%        |4.5%         8.6%         2.3%         12.2%        |
|TERMINAL (d)       |     1/25 (4%)    1/20 (5%)    3/25 (12%)   0/16 (0%)   |2/32 (6%)    2/37 (5%)    1/29 (3%)    4/26 (15%)   |
|FIRST INCIDENCE    |     695          722 (T)      722 (T)      647         |729 (T)      533          729 (T)      616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.599N     P=0.580N     P=0.491      P=0.604N    |P=0.125      P=0.391      P=0.535N     P=0.145      |
|POLY 3             |     P=0.499N     P=0.513N     P=0.496      P=0.524N    |P=0.181      P=0.361      P=0.504N     P=0.185      |
|POLY 1.5           |     P=0.487N     P=0.507N     P=0.500      P=0.512N    |P=0.194      P=0.351      P=0.501N     P=0.199      |
|POLY 6             |     P=0.518N     P=0.529N     P=0.484      P=0.544N    |P=0.165      P=0.375      P=0.508N     P=0.167      |
|LOGISTIC REGRESSION|     P=0.542N     P=0.561N     P=0.463      P=0.529N    |P=0.195      P=0.317      P=0.535N     P=0.157      |
|COCH-ARM / FISHERS |     P=0.471N     P=0.508N     P=0.500      P=0.500N    |P=0.210      P=0.339      P=0.500N     P=0.218      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    1/50 (2%)    2/50 (4%)   |6/50 (12%)   1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.7%         2.5%         2.4%         5.2%        |13.0%        2.2%         2.3%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    0/25 (0%)    0/16 (0%)   |1/32 (3%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     388          722 (T)      538          627         |399          488          707          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.505      P=0.521N     P=0.500N     P=0.650     |P=0.012N*    P=0.056N     P=0.074N     P=0.033N*    |
|POLY 3             |     P=0.533      P=0.523N     P=0.508N     P=0.661     |P=0.008N**   P=0.055N     P=0.064N     P=0.023N*    |
|POLY 1.5           |     P=0.543      P=0.513N     P=0.503N     P=0.675     |P=0.007N**   P=0.055N     P=0.060N     P=0.019N*    |
|POLY 6             |     P=0.518      P=0.542N     P=0.518N     P=0.636     |P=0.009N**   P=0.054N     P=0.068N     P=0.029N*    |
|LOGISTIC REGRESSION|     P=0.604      P=0.598N     P=0.556N     P=0.665N    |P=0.003N**   P=0.079N     P=0.058N     P=0.009N**   |
|COCH-ARM / FISHERS |     P=0.558      P=0.508N     P=0.500N     P=0.691N    |P=0.007N**   P=0.056N     P=0.056N     P=0.013N*    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    11/49 (22%)  20/50 (40%)  25/50 (50%) |6/50 (12%)   2/50 (4%)    6/50 (12%)   17/50 (34%)  |
|POLY-3 ADJUSTED (b)|     9.6%         27.1%        45.2%        59.5%       |13.2%        4.3%         13.3%        40.9%        |
|TERMINAL (d)       |     1/25 (4%)    6/20 (30%)   10/25 (40%)  11/16 (69%) |2/32 (6%)    1/37 (3%)    1/29 (3%)    15/26 (58%)  |
|FIRST INCIDENCE    |     644          665          525          523         |596          570          561          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.022 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.119N     P=0.580      P=0.002 **   |
|POLY 3             |     P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.126N     P=0.619      P=0.003 **   |
|POLY 1.5           |     P<0.001 **   P=0.039 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.129N     P=0.620N     P=0.004 **   |
|POLY 6             |     P<0.001 **   P=0.028 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.123N     P=0.615      P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.032 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.150N     P=0.621N     P=0.003 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.041 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.134N     P=0.620N     P=0.008 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Tension Lipidosis                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |6.6%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |399          533          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.051N     P=0.298N     P=0.127N     P=0.148N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.046N*    P=0.301N     P=0.126N     P=0.141N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.045N*    P=0.303N     P=0.123N     P=0.131N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.047N*    P=0.297N     P=0.131N     P=0.156N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.019N*    P=0.436N     P=0.139N     P=0.066N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.044N*    P=0.309N     P=0.121N     P=0.121N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    6/49 (12%)   13/50 (26%)  17/50 (34%) |10/50 (20%)  7/50 (14%)   9/50 (18%)   18/50 (36%)  |
|POLY-3 ADJUSTED (b)|     9.6%         14.9%        30.6%        42.8%       |22.2%        15.3%        20.3%        43.3%        |
|TERMINAL (d)       |     2/25 (8%)    3/20 (15%)   9/25 (36%)   9/16 (56%)  |6/32 (19%)   7/37 (19%)   7/29 (24%)   15/26 (58%)  |
|FIRST INCIDENCE    |     644          666          534          622         |661          729 (T)      624          616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.256      P=0.018 *    P<0.001 **  |P<0.001 **   P=0.211N     P=0.571N     P=0.013 *    |
|POLY 3             |     P<0.001 **   P=0.348      P=0.014 *    P<0.001 **  |P=0.006 **   P=0.283N     P=0.514N     P=0.027 *    |
|POLY 1.5           |     P<0.001 **   P=0.358      P=0.015 *    P<0.001 **  |P=0.008 **   P=0.288N     P=0.506N     P=0.039 *    |
|POLY 6             |     P<0.001 **   P=0.322      P=0.013 *    P<0.001 **  |P=0.004 **   P=0.277N     P=0.530N     P=0.016 *    |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.322      P=0.016 *    P<0.001 **  |P=0.002 **   P=0.255N     P=0.518N     P=0.016 *    |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.357      P=0.016 *    P<0.001 **  |P=0.014 *    P=0.298N     P=0.500N     P=0.059      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     46/50 (92%)  43/49 (88%)  44/50 (88%)  49/50 (98%) |20/50 (40%)  29/50 (58%)  34/50 (68%)  29/50 (58%)  |
|POLY-3 ADJUSTED (b)|     97.3%        91.5%        92.1%        100.0%      |43.3%        62.1%        72.4%        64.3%        |
|TERMINAL (d)       |     25/25 (100%) 19/20 (95%)  23/25 (92%)  16/16 (100%)|12/32 (38%)  25/37 (68%)  22/29 (76%)  17/26 (65%)  |
|FIRST INCIDENCE    |     434          455          486          428         |622          546          496          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.017 *    P=0.343      P=0.478N     P=0.017 *   |P=0.004 **   P=0.179      P=0.006 **   P=0.015 *    |
|POLY 3             |     P=0.178      P=0.189N     P=0.227N     P=0.378     |P=0.029 *    P=0.049 *    P=0.003 **   P=0.030 *    |
|POLY 1.5           |     P=0.130      P=0.218N     P=0.258N     P=0.214     |P=0.039 *    P=0.052      P=0.003 **   P=0.039 *    |
|POLY 6             |     P=0.238      P=0.208N     P=0.251N     P=0.565     |P=0.019 *    P=0.044 *    P=0.002 **   P=0.022 *    |
|LOGISTIC REGRESSION|     P=0.064      P=0.199N     P=0.242N     P=0.120     |P=0.023 *    P=0.068      P=0.004 **   P=0.034 *    |
|COCH-ARM / FISHERS |     P=0.122      P=0.357N     P=0.370N     P=0.181     |P=0.062      P=0.055      P=0.004 **   P=0.055      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Capsule                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.8%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.037 *    (e)          (e)          P=0.212      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.221      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.228      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.040 *    (e)          (e)          P=0.212      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.065      (e)          (e)          P=0.266      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Cytomegaly                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    4/49 (8%)    8/50 (16%)   6/50 (12%)  |0/50 (0%)    1/50 (2%)    4/50 (8%)    20/50 (40%)  |
|POLY-3 ADJUSTED (b)|     0.0%         10.0%        19.4%        15.6%       |0.0%         2.2%         9.1%         48.6%        |
|TERMINAL (d)       |     0/25 (0%)    3/20 (15%)   7/25 (28%)   5/16 (31%)  |0/32 (0%)    1/37 (3%)    4/29 (14%)   18/26 (69%)  |
|FIRST INCIDENCE    |     ---          666          609          644         |---          729 (T)      729 (T)      649          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.004 **   P=0.042 *    P=0.004 **   P=0.004 **  |P<0.001 **   P=0.529      P=0.050      P<0.001 **   |
|POLY 3             |     P=0.017 *    P=0.056      P=0.003 **   P=0.012 *   |P<0.001 **   P=0.506      P=0.059      P<0.001 **   |
|POLY 1.5           |     P=0.021 *    P=0.058      P=0.004 **   P=0.013 *   |P<0.001 **   P=0.504      P=0.060      P<0.001 **   |
|POLY 6             |     P=0.012 *    P=0.051      P=0.003 **   P=0.009 **  |P<0.001 **   P=0.510      P=0.057      P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.011 *    P=0.046 *    P=0.004 **   P=0.007 **  |P<0.001 **   P=0.529      P=0.050      P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.028 *    P=0.056      P=0.003 **   P=0.013 *   |P<0.001 **   P=0.500      P=0.059      P<0.001 **   |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    2/50 (4%)    8/50 (16%)  |1/50 (2%)    2/50 (4%)    2/50 (4%)    7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     2.4%         7.4%         4.9%         19.8%       |2.2%         4.3%         4.6%         17.2%        |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    1/25 (4%)    2/16 (13%)  |0/32 (0%)    0/37 (0%)    1/29 (3%)    7/26 (27%)   |
|FIRST INCIDENCE    |     388          444          679          428         |661          488          707          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.003 **   P=0.273      P=0.489      P=0.010 *   |P=0.002 **   P=0.510      P=0.483      P=0.014 *    |
|POLY 3             |     P=0.004 **   P=0.294      P=0.492      P=0.012 *   |P=0.005 **   P=0.516      P=0.495      P=0.021 *    |
|POLY 1.5           |     P=0.005 **   P=0.299      P=0.497      P=0.014 *   |P=0.006 **   P=0.510      P=0.498      P=0.025 *    |
|POLY 6             |     P=0.004 **   P=0.281      P=0.483      P=0.010 *   |P=0.004 **   P=0.524      P=0.490      P=0.016 *    |
|LOGISTIC REGRESSION|     P=0.008 **   P=0.194      P=0.484      P=0.021 *   |P=0.007 **   P=0.397      P=0.499      P=0.014 *    |
|COCH-ARM / FISHERS |     P=0.006 **   P=0.301      P=0.500      P=0.015 *   |P=0.008 **   P=0.500      P=0.500      P=0.030 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/49 (6%)    0/50 (0%)    5/50 (10%)  |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.4%         0.0%         12.3%       |2.2%         4.3%         2.3%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          618          ---          194         |503          570          687          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.020 *    P=0.098      (e)          P=0.029 *   |P=0.275N     P=0.508      P=0.752N     P=0.500N     |
|POLY 3             |     P=0.023 *    P=0.115      (e)          P=0.029 *   |P=0.274N     P=0.511      P=0.756      P=0.520N     |
|POLY 1.5           |     P=0.024 *    P=0.117      (e)          P=0.030 *   |P=0.263N     P=0.506      P=0.758      P=0.511N     |
|POLY 6             |     P=0.021 *    P=0.109      (e)          P=0.026 *   |P=0.290N     P=0.519      P=0.753      P=0.532N     |
|LOGISTIC REGRESSION|     P=0.037 *    P=0.117      (e)          P=0.037 *   |P=0.177N     P=0.371      P=0.737      P=0.424N     |
|COCH-ARM / FISHERS |     P=0.026 *    P=0.117      (e)          P=0.028 *   |P=0.247N     P=0.500      P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Periportal                                                                                                                |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    29/50 (58%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.9%         69.0%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    1/25 (4%)    12/16 (75%) |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          673          523         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          P=0.233      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 3             |     P<0.001 **   (e)          P=0.236      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P<0.001 **   (e)          P=0.238      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 6             |     P<0.001 **   (e)          P=0.232      P<0.001 **  |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.233      P<0.001 **  |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.247      P<0.001 **  |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         0.0%         5.2%        |2.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          664          ---          647         |649          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123      P=0.500      (e)          P=0.213     |P=0.335N     P=0.495N     P=0.510N     P=0.553N     |
|POLY 3             |     P=0.131      P=0.498      (e)          P=0.223     |P=0.299N     P=0.495N     P=0.503N     P=0.518N     |
|POLY 1.5           |     P=0.135      P=0.501      (e)          P=0.230     |P=0.302N     P=0.497N     P=0.502N     P=0.510N     |
|POLY 6             |     P=0.125      P=0.490      (e)          P=0.212     |P=0.293N     P=0.493N     P=0.507N     P=0.531N     |
|LOGISTIC REGRESSION|     P=0.138      P=0.500      (e)          P=0.234     |P=0.285N     P=0.527N     P=0.506N     P=0.478N     |
|COCH-ARM / FISHERS |     P=0.140      P=0.500      (e)          P=0.247     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.9%         5.1%        |0.0%         0.0%         0.0%         2.5%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    1/25 (4%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    1/26 (4%)    |
|FIRST INCIDENCE    |     ---          ---          648          520         |---          ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.058      (e)          P=0.237      P=0.191     |P=0.163      (e)          (e)          P=0.459      |
|POLY 3             |     P=0.076      (e)          P=0.237      P=0.224     |P=0.186      (e)          (e)          P=0.483      |
|POLY 1.5           |     P=0.080      (e)          P=0.238      P=0.231     |P=0.192      (e)          (e)          P=0.490      |
|POLY 6             |     P=0.070      (e)          P=0.233      P=0.213     |P=0.179      (e)          (e)          P=0.472      |
|LOGISTIC REGRESSION|     P=0.088      (e)          P=0.236      P=0.246     |(e)          (e)          (e)          P=0.459      |
|COCH-ARM / FISHERS |     P=0.086      (e)          P=0.247      P=0.247     |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    9/50 (18%)   9/50 (18%)  |13/50 (26%)  10/50 (20%)  9/50 (18%)   11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     14.6%        9.8%         21.1%        23.2%       |28.2%        21.9%        19.9%        26.2%        |
|TERMINAL (d)       |     6/25 (24%)   3/20 (15%)   5/25 (20%)   7/16 (44%)  |9/32 (28%)   10/37 (27%)  5/29 (17%)   8/26 (31%)   |
|FIRST INCIDENCE    |     722 (T)      607          269          622         |399          729 (T)      561          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.033 *    P=0.495N     P=0.281      P=0.062     |P=0.445      P=0.210N     P=0.300N     P=0.576      |
|POLY 3             |     P=0.104      P=0.371N     P=0.313      P=0.240     |P=0.483N     P=0.322N     P=0.246N     P=0.511N     |
|POLY 1.5           |     P=0.116      P=0.364N     P=0.309      P=0.263     |P=0.447N     P=0.321N     P=0.242N     P=0.467N     |
|POLY 6             |     P=0.087      P=0.393N     P=0.307      P=0.203     |P=0.531N     P=0.322N     P=0.251N     P=0.571N     |
|LOGISTIC REGRESSION|     P=0.101      P=0.456N     P=0.288      P=0.122     |P=0.440N     P=0.305N     P=0.232N     P=0.434N     |
|COCH-ARM / FISHERS |     P=0.135      P=0.370N     P=0.288      P=0.288     |P=0.397N     P=0.318N     P=0.235N     P=0.408N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   10/50 (20%)  12/50 (24%)  9/50 (18%)  |9/50 (18%)   8/50 (16%)   6/50 (12%)   8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     19.0%        23.9%        28.3%        23.5%       |20.2%        17.4%        13.6%        19.3%        |
|TERMINAL (d)       |     6/25 (24%)   4/20 (20%)   6/25 (24%)   8/16 (50%)  |8/32 (25%)   6/37 (16%)   4/29 (14%)   6/26 (23%)   |
|FIRST INCIDENCE    |     388          444          596          717         |687          666          700          583          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.188      P=0.240      P=0.223      P=0.154     |P=0.440      P=0.382N     P=0.344N     P=0.536      |
|POLY 3             |     P=0.355      P=0.389      P=0.227      P=0.413     |P=0.499N     P=0.470N     P=0.293N     P=0.564N     |
|POLY 1.5           |     P=0.401      P=0.401      P=0.228      P=0.453     |P=0.471N     P=0.482N     P=0.290N     P=0.535N     |
|POLY 6             |     P=0.287      P=0.358      P=0.225      P=0.348     |P=0.539N     P=0.451N     P=0.298N     P=0.605N     |
|LOGISTIC REGRESSION|     P=0.374      P=0.395      P=0.225      P=0.369     |P=0.520      P=0.440N     P=0.307N     P=0.581      |
|COCH-ARM / FISHERS |     P=0.464      P=0.398      P=0.227      P=0.500     |P=0.434N     P=0.500N     P=0.288N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.3%         0.0%         7.8%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    2/16 (13%)  |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          607          ---          717         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.104      P=0.106      (e)          P=0.057     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.146      P=0.119      (e)          P=0.105     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.154      P=0.120      (e)          P=0.112     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.132      P=0.113      (e)          P=0.095     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.142      P=0.120      (e)          P=0.056     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.163      P=0.121      (e)          P=0.121     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    2/50 (4%)    3/50 (6%)   |3/49 (6%)    4/50 (8%)    9/50 (18%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     9.7%         7.4%         4.9%         7.8%        |6.8%         8.6%         20.3%        4.9%         |
|TERMINAL (d)       |     3/25 (12%)   2/20 (10%)   2/25 (8%)    2/16 (13%)  |3/32 (9%)    3/37 (8%)    7/29 (24%)   2/26 (8%)    |
|FIRST INCIDENCE    |     692          708          722 (T)      598         |729 (T)      533          573          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.573      P=0.631N     P=0.346N     P=0.609     |P=0.509      P=0.571      P=0.043 *    P=0.595N     |
|POLY 3             |     P=0.443N     P=0.509N     P=0.340N     P=0.535N    |P=0.555N     P=0.530      P=0.061      P=0.534N     |
|POLY 1.5           |     P=0.433N     P=0.499N     P=0.337N     P=0.518N    |P=0.511N     P=0.523      P=0.063      P=0.515N     |
|POLY 6             |     P=0.459N     P=0.534N     P=0.352N     P=0.567N    |P=0.506      P=0.541      P=0.058      P=0.562N     |
|LOGISTIC REGRESSION|     P=0.514N     P=0.611N     P=0.373N     P=0.578N    |P=0.537N     P=0.512      P=0.057      P=0.595N     |
|COCH-ARM / FISHERS |     P=0.420N     P=0.500N     P=0.339N     P=0.500N    |P=0.456N     P=0.511      P=0.065      P=0.490N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    5/50 (10%)   0/50 (0%)    4/50 (8%)   |3/50 (6%)    1/50 (2%)    4/50 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         12.1%        0.0%         10.3%       |6.6%         2.2%         8.8%         2.4%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    0/25 (0%)    1/16 (6%)   |1/32 (3%)    0/37 (0%)    1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          625          ---          598         |493          570          561          672          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.099      P=0.023 *    (e)          P=0.033 *   |P=0.403N     P=0.294N     P=0.480      P=0.367N     |
|POLY 3             |     P=0.143      P=0.030 *    (e)          P=0.052     |P=0.397N     P=0.297N     P=0.500      P=0.342N     |
|POLY 1.5           |     P=0.151      P=0.031 *    (e)          P=0.056     |P=0.374N     P=0.301N     P=0.500      P=0.326N     |
|POLY 6             |     P=0.128      P=0.027 *    (e)          P=0.046 *   |P=0.429N     P=0.292N     P=0.499      P=0.365N     |
|LOGISTIC REGRESSION|     P=0.145      P=0.032 *    (e)          P=0.053     |P=0.236N     P=0.381N     P=0.481      P=0.256N     |
|COCH-ARM / FISHERS |     P=0.164      P=0.028 *    (e)          P=0.059     |P=0.343N     P=0.309N     P=0.500      P=0.309N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.4%         4.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     574          607          585          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.405N     P=0.750N     P=0.491      P=0.514N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.395N     P=0.757      P=0.498      P=0.517N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.382N     P=0.760N     P=0.501      P=0.509N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.417N     P=0.748      P=0.490      P=0.531N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.345N     P=0.734      P=0.492      P=0.481N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.366N     P=0.753N     P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/47 (4%)    0/50 (0%)    1/48 (2%)   |2/49 (4%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.2%         0.0%         2.7%        |4.5%         0.0%         6.6%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          708          ---          681         |622          ---          561          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.459      P=0.173      (e)          P=0.452     |P=0.333N     P=0.231N     P=0.488      P=0.282N     |
|POLY 3             |     P=0.516      P=0.221      (e)          P=0.482     |P=0.332N     P=0.231N     P=0.506      P=0.258N     |
|POLY 1.5           |     P=0.528      P=0.224      (e)          P=0.488     |P=0.314N     P=0.232N     P=0.508      P=0.247N     |
|POLY 6             |     P=0.494      P=0.213      (e)          P=0.470     |P=0.359N     P=0.231N     P=0.504      P=0.275N     |
|LOGISTIC REGRESSION|     P=0.500      P=0.195      (e)          P=0.483     |P=0.195N     P=0.250N     P=0.514      P=0.200N     |
|COCH-ARM / FISHERS |     P=0.534      P=0.232      (e)          P=0.490     |P=0.291N     P=0.242N     P=0.510      P=0.242N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/47 (6%)    2/50 (4%)    1/48 (2%)   |0/49 (0%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         7.8%         4.9%         2.7%        |0.0%         0.0%         9.1%         0.0%         |
|TERMINAL (d)       |     2/25 (8%)    3/20 (15%)   2/25 (8%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    4/29 (14%)   0/26 (0%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      722 (T)      722 (T)     |---          ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.451N     P=0.397      P=0.697      P=0.655N    |P=0.418      (e)          P=0.050      (e)          |
|POLY 3             |     P=0.342N     P=0.468      P=0.692      P=0.534N    |P=0.426      (e)          P=0.059      (e)          |
|POLY 1.5           |     P=0.330N     P=0.474      P=0.693N     P=0.522N    |P=0.460      (e)          P=0.061      (e)          |
|POLY 6             |     P=0.366N     P=0.450      P=0.684      P=0.556N    |P=0.378      (e)          P=0.057      (e)          |
|LOGISTIC REGRESSION|     P=0.451N     P=0.397      P=0.697      P=0.655N    |(e)          (e)          P=0.050      (e)          |
|COCH-ARM / FISHERS |     P=0.321N     P=0.470      P=0.691N     P=0.515N    |P=0.505      (e)          P=0.061      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/47 (0%)    2/50 (4%)    0/48 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.9%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    1/25 (4%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          632          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.553      (e)          P=0.240      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.559      (e)          P=0.237      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.577      (e)          P=0.238      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.526      (e)          P=0.233      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.586      (e)          P=0.237      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.591      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/47 (0%)    0/50 (0%)    0/48 (0%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         0.0%         4.9%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    2/26 (8%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          488          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.211      P=0.242      (e)          P=0.193      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.226      P=0.252      (e)          P=0.220      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.237      P=0.248      (e)          P=0.229      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.213      P=0.257      (e)          P=0.207      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.339      P=0.117      (e)          P=0.193      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.251      P=0.253      (e)          P=0.253      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/47 (6%)    0/50 (0%)    0/48 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.7%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          604          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.348N     P=0.121      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.324N     P=0.109      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.316N     P=0.110      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.342N     P=0.105      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.314N     P=0.105      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.316N     P=0.110      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/20 (0%)    0/25 (0%)    0/20 (0%)    0/23 (0%)   |2/7 (29%)    0/9 (0%)     0/15 (0%)    0/19 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |31.8%        0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/5 (0%)     0/7 (0%)     0/5 (0%)     0/6 (0%)    |0/2 (0%)     0/4 (0%)     0/4 (0%)     0/4 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |493          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.124N     P=0.240N     P=0.240N     P=0.269N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.019N*    P=0.170N     P=0.091N     P=0.057N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.021N*    P=0.167N     P=0.081N     P=0.049N*    |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.018N*    P=0.173N     P=0.106N     P=0.072N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.019N*    P=0.249N     P=0.060N     P=0.035N*    |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.039N*    P=0.175N     P=0.091N     P=0.065N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/20 (0%)    0/25 (0%)    0/20 (0%)    0/23 (0%)   |0/7 (0%)     0/9 (0%)     0/15 (0%)    2/19 (11%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         14.7%        |
|TERMINAL (d)       |     0/5 (0%)     0/7 (0%)     0/5 (0%)     0/6 (0%)    |0/2 (0%)     0/4 (0%)     0/4 (0%)     2/4 (50%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.059      (e)          (e)          P=0.390      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.105      (e)          (e)          P=0.457      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.112      (e)          (e)          P=0.465      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.094      (e)          (e)          P=0.443      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.390      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.120      (e)          (e)          P=0.526      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Pancreatic                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/20 (0%)    0/25 (0%)    1/20 (5%)    2/23 (9%)   |0/7 (0%)     0/9 (0%)     1/15 (7%)    0/19 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         6.6%         10.9%       |0.0%         0.0%         8.8%         0.0%         |
|TERMINAL (d)       |     0/5 (0%)     0/7 (0%)     0/5 (0%)     0/6 (0%)    |0/2 (0%)     0/4 (0%)     0/4 (0%)     0/4 (0%)     |
|FIRST INCIDENCE    |     ---          ---          708          598         |---          ---          624          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.056      (e)          P=0.479      P=0.231     |P=0.677      (e)          P=0.491      (e)          |
|POLY 3             |     P=0.078      (e)          P=0.499      P=0.275     |P=0.704N     (e)          P=0.651      (e)          |
|POLY 1.5           |     P=0.077      (e)          P=0.502      P=0.273     |P=0.694N     (e)          P=0.650      (e)          |
|POLY 6             |     P=0.081      (e)          P=0.490      P=0.277     |P=0.719N     (e)          P=0.655      (e)          |
|LOGISTIC REGRESSION|     P=0.073      (e)          P=0.469      P=0.248     |P=0.667N     (e)          P=0.665      (e)          |
|COCH-ARM / FISHERS |     P=0.074      (e)          P=0.500      P=0.280     |P=0.684N     (e)          P=0.682      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/20 (5%)    0/25 (0%)    1/20 (5%)    3/23 (13%)  |1/7 (14%)    1/9 (11%)    1/15 (7%)    0/19 (0%)    |
|POLY-3 ADJUSTED (b)|     6.4%         0.0%         6.5%         16.2%       |16.5%        12.3%        8.7%         0.0%         |
|TERMINAL (d)       |     0/5 (0%)     0/7 (0%)     0/5 (0%)     0/6 (0%)    |0/2 (0%)     0/4 (0%)     0/4 (0%)     0/4 (0%)     |
|FIRST INCIDENCE    |     571          ---          609          598         |493          570          605          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.086      P=0.500N     P=0.760N     P=0.273     |P=0.322N     P=0.760      P=0.758      P=0.504N     |
|POLY 3             |     P=0.106      P=0.461N     P=0.760      P=0.359     |P=0.147N     P=0.696N     P=0.617N     P=0.326N     |
|POLY 1.5           |     P=0.104      P=0.456N     P=0.761N     P=0.360     |P=0.136N     P=0.700N     P=0.603N     P=0.312N     |
|POLY 6             |     P=0.110      P=0.473N     P=0.751      P=0.357     |P=0.165N     P=0.687N     P=0.630N     P=0.347N     |
|LOGISTIC REGRESSION|     P=0.093      P=0.508N     P=0.739      P=0.334     |P=0.050N     (e)          P=0.580N     P=0.197N     |
|COCH-ARM / FISHERS |     P=0.102      P=0.444N     P=0.756N     P=0.359     |P=0.121N     P=0.700N     P=0.545N     P=0.269N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/20 (0%)    0/25 (0%)    2/20 (10%)   0/23 (0%)   |0/7 (0%)     0/9 (0%)     0/15 (0%)    1/19 (5%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         12.8%        0.0%        |0.0%         0.0%         0.0%         7.2%         |
|TERMINAL (d)       |     0/5 (0%)     0/7 (0%)     1/5 (20%)    0/6 (0%)    |0/2 (0%)     0/4 (0%)     0/4 (0%)     0/4 (0%)     |
|FIRST INCIDENCE    |     ---          ---          534          ---         |---          ---          ---          673          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.595      (e)          P=0.242      (e)         |P=0.169      (e)          (e)          P=0.465      |
|POLY 3             |     P=0.609      (e)          P=0.238      (e)         |P=0.300      (e)          (e)          P=0.690      |
|POLY 1.5           |     P=0.612      (e)          P=0.239      (e)         |P=0.309      (e)          (e)          P=0.693      |
|POLY 6             |     P=0.601      (e)          P=0.231      (e)         |P=0.288      (e)          (e)          P=0.688      |
|LOGISTIC REGRESSION|     P=0.602      (e)          P=0.225      (e)         |P=0.301      (e)          (e)          P=0.689      |
|COCH-ARM / FISHERS |     P=0.608      (e)          P=0.244      (e)         |P=0.316      (e)          (e)          P=0.731      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/20 (0%)    0/25 (0%)    1/20 (5%)    4/23 (17%)  |0/7 (0%)     0/9 (0%)     0/15 (0%)    0/19 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         6.6%         22.6%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/5 (0%)     0/7 (0%)     1/5 (20%)    2/6 (33%)   |0/2 (0%)     0/4 (0%)     0/4 (0%)     0/4 (0%)     |
|FIRST INCIDENCE    |     ---          ---          722 (T)      685         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.004 **   (e)          P=0.500      P=0.050     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.004 **   (e)          P=0.498      P=0.067     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.005 **   (e)          P=0.502      P=0.070     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.004 **   (e)          P=0.489      P=0.061     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.004 **   (e)          P=0.500      P=0.050     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.006 **   (e)          P=0.500      P=0.072     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    1/50 (2%)    0/49 (0%)   |3/50 (6%)    5/50 (10%)   1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.4%         0.0%        |6.7%         10.8%        2.3%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |1/32 (3%)    4/37 (11%)   1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          700          ---         |661          611          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.653      (e)          P=0.487      (e)         |P=0.062N     P=0.420      P=0.338N     P=0.174N     |
|POLY 3             |     P=0.664      (e)          P=0.503      (e)         |P=0.044N*    P=0.375      P=0.311N     P=0.136N     |
|POLY 1.5           |     P=0.678      (e)          P=0.505      (e)         |P=0.040N*    P=0.368      P=0.308N     P=0.128N     |
|POLY 6             |     P=0.640      (e)          P=0.498      (e)         |P=0.051N     P=0.384      P=0.317N     P=0.148N     |
|LOGISTIC REGRESSION|     P=0.682      (e)          P=0.499      (e)         |P=0.043N*    P=0.363      P=0.309N     P=0.134N     |
|COCH-ARM / FISHERS |     P=0.696      (e)          P=0.505      (e)         |P=0.037N*    P=0.357      P=0.309N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    3/48 (6%)    2/50 (4%)    3/49 (6%)   |5/50 (10%)   2/50 (4%)    6/50 (12%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     2.5%         7.7%         4.9%         7.9%        |11.3%        4.4%         13.5%        12.0%        |
|TERMINAL (d)       |     1/25 (4%)    3/20 (15%)   2/25 (8%)    2/16 (13%)  |5/32 (16%)   2/37 (5%)    5/29 (17%)   2/26 (8%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      722 (T)      465         |729 (T)      729 (T)      561          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.176      P=0.226      P=0.500      P=0.196     |P=0.250      P=0.160N     P=0.437      P=0.496      |
|POLY 3             |     P=0.281      P=0.291      P=0.505      P=0.285     |P=0.348      P=0.203N     P=0.501      P=0.591      |
|POLY 1.5           |     P=0.293      P=0.298      P=0.508      P=0.295     |P=0.370      P=0.209N     P=0.502      P=0.608      |
|POLY 6             |     P=0.258      P=0.274      P=0.495      P=0.265     |P=0.320      P=0.196N     P=0.499      P=0.569      |
|LOGISTIC REGRESSION|     P=0.264      P=0.226      P=0.500      P=0.302     |P=0.344      P=0.160N     P=0.487      P=0.578      |
|COCH-ARM / FISHERS |     P=0.305      P=0.301      P=0.508      P=0.309     |P=0.401      P=0.218N     P=0.500      P=0.630N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland: Duct                                                                                                              |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/49 (29%)  16/48 (33%)  12/50 (24%)  15/49 (31%) |13/50 (26%)  9/50 (18%)   13/50 (26%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     32.8%        39.7%        27.5%        36.0%       |28.4%        19.0%        28.4%        29.5%        |
|TERMINAL (d)       |     7/25 (28%)   7/20 (35%)   7/25 (28%)   3/16 (19%)  |8/32 (25%)   6/37 (16%)   7/29 (24%)   4/26 (15%)   |
|FIRST INCIDENCE    |     434          641          269          523         |588          488          496          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.263      P=0.232      P=0.433N     P=0.243     |P=0.208      P=0.172N     P=0.503      P=0.391      |
|POLY 3             |     P=0.528      P=0.335      P=0.381N     P=0.468     |P=0.349      P=0.204N     P=0.588N     P=0.546      |
|POLY 1.5           |     P=0.533      P=0.368      P=0.373N     P=0.481     |P=0.375      P=0.215N     P=0.585N     P=0.565      |
|POLY 6             |     P=0.514      P=0.278      P=0.415N     P=0.445     |P=0.317      P=0.194N     P=0.584      P=0.521      |
|LOGISTIC REGRESSION|     P=0.532      P=0.375      P=0.389N     P=0.497     |P=0.495      P=0.253N     P=0.589N     P=0.564N     |
|COCH-ARM / FISHERS |     P=0.541N     P=0.387      P=0.387N     P=0.500     |P=0.411      P=0.235N     P=0.590N     P=0.590N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/11 (91%)  13/14 (93%)  6/7 (86%)    8/8 (100%)  |8/9 (89%)    9/11 (82%)   6/7 (86%)    11/12 (92%)  |
|POLY-3 ADJUSTED (b)|     91.0%        95.2%        87.8%        100.0%      |88.9%        92.0%        87.2%        91.7%        |
|TERMINAL (d)       |     4/4 (100%)   6/6 (100%)   3/3 (100%)   2/2 (100%)  |6/7 (86%)    6/6 (100%)   3/3 (100%)   4/5 (80%)    |
|FIRST INCIDENCE    |     388          604          640          523         |671          642          496          380          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.534      P=0.430      P=0.264N     P=0.511     |P=0.042 *    P=0.380      P=0.406      P=0.084      |
|POLY 3             |     P=0.423      P=0.659      P=0.718N     P=0.568     |P=0.583      P=0.727      P=0.744N     P=0.695      |
|POLY 1.5           |     P=0.421      P=0.683      P=0.688N     P=0.565     |P=0.531      P=0.751N     P=0.724N     P=0.695      |
|POLY 6             |     P=0.426      P=0.613      P=0.771N     P=0.572     |P=0.638      P=0.612      P=0.780N     P=0.695      |
|LOGISTIC REGRESSION|     P=0.415      P=0.701      P=0.705N     P=0.704     |P=0.368      P=0.525      P=0.624N     (e)          |
|COCH-ARM / FISHERS |     P=0.416      P=0.697      P=0.641N     P=0.579     |P=0.456      P=0.579N     P=0.700N     P=0.686      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     26/50 (52%)  18/50 (36%)  22/49 (45%)  25/50 (50%) |17/50 (34%)  15/50 (30%)  19/50 (38%)  19/50 (38%)  |
|POLY-3 ADJUSTED (b)|     58.3%        40.9%        52.6%        56.2%       |38.0%        32.8%        41.7%        43.7%        |
|TERMINAL (d)       |     13/25 (52%)  8/20 (40%)   14/24 (58%)  8/16 (50%)  |16/32 (50%)  15/37 (41%)  11/29 (38%)  11/26 (42%)  |
|FIRST INCIDENCE    |     388          466          529          194         |622          729 (T)      496          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.121      P=0.264N     P=0.366N     P=0.211     |P=0.065      P=0.224N     P=0.314      P=0.180      |
|POLY 3             |     P=0.419      P=0.069N     P=0.372N     P=0.504N    |P=0.237      P=0.382N     P=0.443      P=0.371      |
|POLY 1.5           |     P=0.429      P=0.066N     P=0.333N     P=0.488N    |P=0.259      P=0.395N     P=0.434      P=0.391      |
|POLY 6             |     P=0.393      P=0.089N     P=0.451N     P=0.553N    |P=0.212      P=0.364N     P=0.457      P=0.347      |
|LOGISTIC REGRESSION|     P=0.387      P=0.077N     P=0.309N     P=0.519N    |P=0.156      P=0.290N     P=0.391      P=0.288      |
|COCH-ARM / FISHERS |     P=0.429      P=0.079N     P=0.307N     P=0.500N    |P=0.291      P=0.415N     P=0.418      P=0.418      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Nasolacrimal Duct                                                                                                          |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         2.6%        |0.0%         4.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    1/24 (4%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          722 (T)      651         |---          533          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.190      (e)          P=0.492      P=0.470     |P=0.435N     P=0.249      (e)          (e)          |
|POLY 3             |     P=0.219      (e)          P=0.494      P=0.487     |P=0.412N     P=0.249      (e)          (e)          |
|POLY 1.5           |     P=0.226      (e)          P=0.496      P=0.493     |P=0.408N     P=0.244      (e)          (e)          |
|POLY 6             |     P=0.207      (e)          P=0.488      P=0.476     |P=0.419N     P=0.255      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.221      (e)          P=0.492      P=0.501     |P=0.328N     P=0.152      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.236      (e)          P=0.495      P=0.500     |P=0.405N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    8/50 (16%)   4/50 (8%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.7%         17.2%        8.9%         9.6%         |
|TERMINAL (d)       |                                                        |2/32 (6%)    6/37 (16%)   2/29 (7%)    1/26 (4%)    |
|FIRST INCIDENCE    |                                                        |503          546          521          616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.510      P=0.146      P=0.473      P=0.409      |
|POLY 3             |                                                        |P=0.540N     P=0.108      P=0.500      P=0.458      |
|POLY 1.5           |                                                        |P=0.516N     P=0.105      P=0.501      P=0.476      |
|POLY 6             |                                                        |P=0.551      P=0.115      P=0.498      P=0.436      |
|LOGISTIC REGRESSION|                                                        |P=0.416N     P=0.092      P=0.488      P=0.550      |
|COCH-ARM / FISHERS |                                                        |P=0.484N     P=0.100      P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  15/48 (31%)  17/50 (34%)  12/49 (24%) |22/49 (45%)  14/50 (28%)  13/50 (26%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     40.7%        36.8%        39.0%        30.6%       |47.9%        30.2%        28.8%        33.3%        |
|TERMINAL (d)       |     9/25 (36%)   11/20 (55%)  9/25 (36%)   8/16 (50%)  |15/32 (47%)  13/37 (35%)  8/29 (28%)   9/26 (35%)   |
|FIRST INCIDENCE    |     388          444          529          465         |399          533          605          608          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.428N     P=0.548N     P=0.521N     P=0.473N    |P=0.311N     P=0.032N*    P=0.096N     P=0.253N     |
|POLY 3             |     P=0.212N     P=0.440N     P=0.521N     P=0.227N    |P=0.127N     P=0.059N     P=0.045N*    P=0.114N     |
|POLY 1.5           |     P=0.180N     P=0.404N     P=0.506N     P=0.188N    |P=0.103N     P=0.059N     P=0.041N*    P=0.088N     |
|POLY 6             |     P=0.277N     P=0.520N     P=0.553N     P=0.308N    |P=0.164N     P=0.061N     P=0.051N     P=0.161N     |
|LOGISTIC REGRESSION|     P=0.173N     P=0.384N     P=0.498N     P=0.174N    |P=0.118N     P=0.057N     P=0.040N*    P=0.094N     |
|COCH-ARM / FISHERS |     P=0.144N     P=0.389N     P=0.500N     P=0.152N    |P=0.077N     P=0.062N     P=0.039N*    P=0.062N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Cytoplasmic Alteration                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         0.0%         0.0%         0.0%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/25 (8%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |1/32 (3%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     722 (T)      ---          ---          ---         |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.140N     P=0.288N     P=0.237N     P=0.340N    |P=0.335N     P=0.471N     P=0.520N     P=0.541N     |
|POLY 3             |     P=0.111N     P=0.248N     P=0.238N     P=0.259N    |P=0.297N     P=0.491N     P=0.499N     P=0.514N     |
|POLY 1.5           |     P=0.113N     P=0.245N     P=0.237N     P=0.250N    |P=0.300N     P=0.493N     P=0.497N     P=0.506N     |
|POLY 6             |     P=0.106N     P=0.256N     P=0.243N     P=0.274N    |P=0.291N     P=0.488N     P=0.502N     P=0.526N     |
|LOGISTIC REGRESSION|     P=0.140N     (e)          (e)          (e)         |P=0.335N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.116N     P=0.258N     P=0.247N     P=0.253N    |P=0.303N     P=0.495N     P=0.495N     P=0.495N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Ectopic Liver                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |0/49 (0%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         4.6%         7.3%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    2/37 (5%)    2/29 (7%)    2/26 (8%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      641          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.059      P=0.271      P=0.216      P=0.087      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.091      P=0.247      P=0.238      P=0.107      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.100      P=0.245      P=0.240      P=0.114      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.079      P=0.250      P=0.234      P=0.099      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.073      P=0.271      P=0.216      P=0.108      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.111      P=0.253      P=0.253      P=0.125      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/48 (8%)    2/50 (4%)    3/49 (6%)   |0/49 (0%)    3/50 (6%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.8%         10.1%        4.9%         7.8%        |0.0%         6.5%         4.6%         0.0%         |
|TERMINAL (d)       |     1/25 (4%)    2/20 (10%)   2/25 (8%)    1/16 (6%)   |0/32 (0%)    2/37 (5%)    2/29 (7%)    0/26 (0%)    |
|FIRST INCIDENCE    |     571          665          722 (T)      428         |---          570          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.392      P=0.270      P=0.692      P=0.412     |P=0.480N     P=0.140      P=0.216      (e)          |
|POLY 3             |     P=0.485      P=0.311      P=0.688      P=0.464     |P=0.447N     P=0.129      P=0.238      (e)          |
|POLY 1.5           |     P=0.501      P=0.319      P=0.692      P=0.478     |P=0.427N     P=0.127      P=0.240      (e)          |
|POLY 6             |     P=0.456      P=0.294      P=0.677      P=0.438     |P=0.477N     P=0.133      P=0.234      (e)          |
|LOGISTIC REGRESSION|     P=0.511      P=0.316      P=0.694      P=0.516     |P=0.415N     P=0.113      P=0.216      (e)          |
|COCH-ARM / FISHERS |     P=0.517      P=0.319      P=0.691N     P=0.490     |P=0.404N     P=0.125      P=0.253      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/48 (0%)    3/50 (6%)    0/49 (0%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.4%         0.0%         7.3%         0.0%        |0.0%         0.0%         2.3%         4.9%         |
|TERMINAL (d)       |     1/25 (4%)    0/20 (0%)    3/25 (12%)   0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    1/26 (4%)    |
|FIRST INCIDENCE    |     722 (T)      ---          722 (T)      ---         |---          ---          707          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.610N     P=0.545N     P=0.303      P=0.589N    |P=0.050      (e)          P=0.494      P=0.212      |
|POLY 3             |     P=0.535N     P=0.510N     P=0.302      P=0.519N    |P=0.061      (e)          P=0.501      P=0.224      |
|POLY 1.5           |     P=0.521N     P=0.507N     P=0.306      P=0.512N    |P=0.066      (e)          P=0.503      P=0.232      |
|POLY 6             |     P=0.557N     P=0.518N     P=0.293      P=0.532N    |P=0.056      (e)          P=0.499      P=0.213      |
|LOGISTIC REGRESSION|     P=0.610N     (e)          P=0.303      (e)         |P=0.080      (e)          P=0.501      P=0.260      |
|COCH-ARM / FISHERS |     P=0.502N     P=0.510N     P=0.309      P=0.505N    |P=0.071      (e)          P=0.505      P=0.253      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    3/48 (6%)   |1/48 (2%)    0/50 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         7.3%         8.0%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    2/25 (8%)    2/16 (13%)  |0/31 (0%)    0/37 (0%)    0/28 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          722 (T)      679          670         |503          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.032 *    P=0.455      P=0.117      P=0.071     |P=0.306N     P=0.496N     P=0.496N     P=0.500N     |
|POLY 3             |     P=0.052      P=0.497      P=0.118      P=0.102     |P=0.295N     P=0.488N     P=0.505N     P=0.511N     |
|POLY 1.5           |     P=0.057      P=0.500      P=0.119      P=0.108     |P=0.299N     P=0.490N     P=0.503N     P=0.503N     |
|POLY 6             |     P=0.045 *    P=0.488      P=0.113      P=0.093     |P=0.290N     P=0.485N     P=0.508N     P=0.523N     |
|LOGISTIC REGRESSION|     P=0.040 *    P=0.455      P=0.111      P=0.086     |P=0.239N     P=0.680N     P=0.651N     P=0.422N     |
|COCH-ARM / FISHERS |     P=0.061      P=0.500      P=0.121      P=0.114     |P=0.302N     P=0.490N     P=0.500N     P=0.490N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |11/49 (22%)  9/50 (18%)   12/50 (24%)  4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.9%         4.9%         5.2%        |24.9%        19.0%        27.0%        9.5%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    2/25 (8%)    0/16 (0%)   |8/31 (26%)   5/37 (14%)   10/29 (35%)  0/26 (0%)    |
|FIRST INCIDENCE    |     ---          698          722 (T)      676         |622          546          549          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.156      P=0.193      P=0.237      P=0.185     |P=0.139N     P=0.295N     P=0.437      P=0.107N     |
|POLY 3             |     P=0.216      P=0.234      P=0.235      P=0.223     |P=0.075N     P=0.335N     P=0.509      P=0.053N     |
|POLY 1.5           |     P=0.228      P=0.238      P=0.237      P=0.229     |P=0.062N     P=0.354N     P=0.518      P=0.047N*    |
|POLY 6             |     P=0.196      P=0.224      P=0.230      P=0.211     |P=0.096N     P=0.312N     P=0.492      P=0.062N     |
|LOGISTIC REGRESSION|     P=0.193      P=0.206      P=0.237      P=0.221     |P=0.053N     P=0.390N     P=0.509      P=0.047N*    |
|COCH-ARM / FISHERS |     P=0.242      P=0.247      P=0.247      P=0.247     |P=0.048N*    P=0.382N     P=0.522      P=0.041N*    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    8/50 (16%)   3/50 (6%)    1/50 (2%)   |16/49 (33%)  18/50 (36%)  20/50 (40%)  8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     4.9%         19.2%        7.3%         2.6%        |36.1%        38.4%        42.4%        19.1%        |
|TERMINAL (d)       |     1/25 (4%)    4/20 (20%)   3/25 (12%)   0/16 (0%)   |13/31 (42%)  16/37 (43%)  11/29 (38%)  5/26 (19%)   |
|FIRST INCIDENCE    |     718          598          722 (T)      691         |493          488          549          583          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.265N     P=0.029 *    P=0.490      P=0.641N    |P=0.142N     P=0.530N     P=0.228      P=0.122N     |
|POLY 3             |     P=0.175N     P=0.045 *    P=0.497      P=0.524N    |P=0.055N     P=0.493      P=0.340      P=0.061N     |
|POLY 1.5           |     P=0.161N     P=0.047 *    P=0.501      P=0.513N    |P=0.043N*    P=0.474      P=0.319      P=0.052N     |
|POLY 6             |     P=0.203N     P=0.039 *    P=0.486      P=0.545N    |P=0.076N     P=0.519      P=0.370      P=0.075N     |
|LOGISTIC REGRESSION|     P=0.190N     P=0.042 *    P=0.458      P=0.581N    |P=0.039N*    P=0.481      P=0.291      P=0.066N     |
|COCH-ARM / FISHERS |     P=0.151N     P=0.046 *    P=0.500      P=0.500N    |P=0.031N*    P=0.445      P=0.291      P=0.044N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     22/50 (44%)  16/50 (32%)  18/50 (36%)  12/50 (24%) |22/49 (45%)  29/50 (58%)  21/50 (42%)  18/50 (36%)  |
|POLY-3 ADJUSTED (b)|     50.9%        37.2%        40.9%        29.1%       |48.3%        60.7%        45.2%        41.2%        |
|TERMINAL (d)       |     15/25 (60%)  7/20 (35%)   10/25 (40%)  5/16 (31%)  |17/31 (55%)  23/37 (62%)  15/29 (52%)  11/26 (42%)  |
|FIRST INCIDENCE    |     388          466          486          520         |399          533          561          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.200N     P=0.371N     P=0.296N     P=0.232N    |P=0.387N     P=0.333      P=0.564      P=0.518N     |
|POLY 3             |     P=0.037N*    P=0.137N     P=0.229N     P=0.029N*   |P=0.135N     P=0.156      P=0.465N     P=0.320N     |
|POLY 1.5           |     P=0.036N*    P=0.136N     P=0.242N     P=0.027N*   |P=0.112N     P=0.144      P=0.467N     P=0.289N     |
|POLY 6             |     P=0.041N*    P=0.154N     P=0.222N     P=0.035N*   |P=0.169N     P=0.181      P=0.461N     P=0.361N     |
|LOGISTIC REGRESSION|     P=0.043N*    P=0.151N     P=0.266N     P=0.037N*   |P=0.106N     P=0.145      P=0.465N     P=0.271N     |
|COCH-ARM / FISHERS |     P=0.035N*    P=0.151N     P=0.270N     P=0.028N*   |P=0.084N     P=0.135      P=0.465N     P=0.243N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/47 (6%)    5/49 (10%)   4/48 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     9.6%         7.8%         12.4%        10.7%       |                                                    |
|TERMINAL (d)       |     3/25 (12%)   1/19 (5%)    5/25 (20%)   3/16 (19%)  |                                                    |
|FIRST INCIDENCE    |     604          607          722 (T)      444         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.331      P=0.578N     P=0.500      P=0.452     |                                                    |
|POLY 3             |     P=0.443      P=0.539N     P=0.479      P=0.587     |                                                    |
|POLY 1.5           |     P=0.463      P=0.531N     P=0.486      P=0.604     |                                                    |
|POLY 6             |     P=0.409      P=0.559N     P=0.462      P=0.553     |                                                    |
|LOGISTIC REGRESSION|     P=0.443      P=0.537N     P=0.464      P=0.602     |                                                    |
|COCH-ARM / FISHERS |     P=0.486      P=0.535N     P=0.487      P=0.619     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/47 (0%)    0/49 (0%)    2/48 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.8%         0.0%         0.0%         5.4%        |                                                    |
|TERMINAL (d)       |     1/25 (4%)    0/19 (0%)    0/25 (0%)    1/16 (6%)   |                                                    |
|FIRST INCIDENCE    |     604          ---          ---          719         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.418      P=0.259N     P=0.240N     P=0.568     |                                                    |
|POLY 3             |     P=0.485      P=0.256N     P=0.244N     P=0.650     |                                                    |
|POLY 1.5           |     P=0.487      P=0.252N     P=0.242N     P=0.664     |                                                    |
|POLY 6             |     P=0.484      P=0.268N     P=0.250N     P=0.624     |                                                    |
|LOGISTIC REGRESSION|     P=0.467      P=0.251N     P=0.242N     P=0.647     |                                                    |
|COCH-ARM / FISHERS |     P=0.493      P=0.263N     P=0.253N     P=0.676     |                                                    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 46
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     22/50 (44%)  39/47 (83%)  31/49 (63%)  28/48 (58%) |                                                    |
|POLY-3 ADJUSTED (b)|     50.0%        86.9%        69.9%        65.2%       |                                                    |
|TERMINAL (d)       |     14/25 (56%)  16/19 (84%)  18/25 (72%)  10/16 (63%) |                                                    |
|FIRST INCIDENCE    |     309          444          525          444         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.091      P<0.001 **   P=0.072      P=0.020 *   |                                                    |
|POLY 3             |     P=0.345      P<0.001 **   P=0.037 *    P=0.103     |                                                    |
|POLY 1.5           |     P=0.345      P<0.001 **   P=0.038 *    P=0.104     |                                                    |
|POLY 6             |     P=0.323      P<0.001 **   P=0.038 *    P=0.096     |                                                    |
|LOGISTIC REGRESSION|     P=0.302      P<0.001 **   P=0.042 *    P=0.096     |                                                    |
|COCH-ARM / FISHERS |     P=0.362      P<0.001 **   P=0.042 *    P=0.112     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/47 (4%)    0/49 (0%)    2/48 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         5.2%         0.0%         5.4%        |                                                    |
|TERMINAL (d)       |     0/25 (0%)    1/19 (5%)    0/25 (0%)    1/16 (6%)   |                                                    |
|FIRST INCIDENCE    |     ---          666          ---          644         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.193      P=0.201      (e)          P=0.183     |                                                    |
|POLY 3             |     P=0.226      P=0.221      (e)          P=0.214     |                                                    |
|POLY 1.5           |     P=0.233      P=0.224      (e)          P=0.220     |                                                    |
|POLY 6             |     P=0.212      P=0.213      (e)          P=0.202     |                                                    |
|LOGISTIC REGRESSION|     P=0.222      P=0.216      (e)          P=0.213     |                                                    |
|COCH-ARM / FISHERS |     P=0.242      P=0.232      (e)          P=0.237     |                                                    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 47
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/48 (2%)    4/50 (8%)    2/49 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.4%         2.6%         9.8%         5.4%        |                                                    |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    4/25 (16%)   2/16 (13%)  |                                                    |
|FIRST INCIDENCE    |     579          722 (T)      722 (T)      722 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.190      P=0.741      P=0.181      P=0.392     |                                                    |
|POLY 3             |     P=0.264      P=0.746      P=0.172      P=0.462     |                                                    |
|POLY 1.5           |     P=0.284      P=0.751      P=0.177      P=0.477     |                                                    |
|POLY 6             |     P=0.233      P=0.735      P=0.162      P=0.437     |                                                    |
|LOGISTIC REGRESSION|     P=0.247      P=0.751      P=0.175      P=0.478     |                                                    |
|COCH-ARM / FISHERS |     P=0.310      P=0.742      P=0.181      P=0.492     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/48 (4%)    0/50 (0%)    1/49 (2%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.8%         5.0%         0.0%         2.6%        |                                                    |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |                                                    |
|FIRST INCIDENCE    |     571          466          ---          520         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.324N     P=0.682      P=0.253N     P=0.554N    |                                                    |
|POLY 3             |     P=0.309N     P=0.680      P=0.241N     P=0.533N    |                                                    |
|POLY 1.5           |     P=0.304N     P=0.683      P=0.238N     P=0.520N    |                                                    |
|POLY 6             |     P=0.318N     P=0.668      P=0.249N     P=0.556N    |                                                    |
|LOGISTIC REGRESSION|     P=0.251N     P=0.624      P=0.240N     P=0.481N    |                                                    |
|COCH-ARM / FISHERS |     P=0.298N     P=0.676      P=0.247N     P=0.508N    |                                                    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 48
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     33/50 (66%)  30/48 (63%)  28/50 (56%)  25/49 (51%) |                                                    |
|POLY-3 ADJUSTED (b)|     72.4%        70.5%        61.1%        57.8%       |                                                    |
|TERMINAL (d)       |     18/25 (72%)  14/20 (70%)  15/25 (60%)  8/16 (50%)  |                                                    |
|FIRST INCIDENCE    |     388          538          269          194         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.496N     P=0.409      P=0.293N     P=0.529     |                                                    |
|POLY 3             |     P=0.057N     P=0.518N     P=0.167N     P=0.101N    |                                                    |
|POLY 1.5           |     P=0.056N     P=0.470N     P=0.170N     P=0.092N    |                                                    |
|POLY 6             |     P=0.064N     P=0.599N     P=0.187N     P=0.123N    |                                                    |
|LOGISTIC REGRESSION|     P=0.081N     P=0.422N     P=0.202N     P=0.110N    |                                                    |
|COCH-ARM / FISHERS |     P=0.064N     P=0.440N     P=0.206N     P=0.095N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         6.8%         2.5%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    1/37 (3%)    3/29 (10%)   1/26 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          546          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.360      P=0.258      P=0.103      P=0.459      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.385      P=0.247      P=0.116      P=0.483      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.411      P=0.243      P=0.118      P=0.490      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.348      P=0.252      P=0.114      P=0.472      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.426      P=0.196      P=0.103      P=0.459      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.444      P=0.247      P=0.121      P=0.500      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 49
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         0.0%         0.0%        |0.0%         4.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    1/37 (3%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          701          ---          ---         |---          546          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.630N     P=0.440      (e)          (e)         |P=0.434N     P=0.258      (e)          (e)          |
|POLY 3             |     P=0.571N     P=0.498      (e)          (e)         |P=0.413N     P=0.247      (e)          (e)          |
|POLY 1.5           |     P=0.568N     P=0.501      (e)          (e)         |P=0.409N     P=0.243      (e)          (e)          |
|POLY 6             |     P=0.578N     P=0.489      (e)          (e)         |P=0.420N     P=0.252      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.588N     P=0.487      (e)          (e)         |P=0.360N     P=0.196      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/47 (2%)    2/50 (4%)    2/48 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.9%         2.6%         4.9%         5.4%        |                                                    |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    0/25 (0%)    1/16 (6%)   |                                                    |
|FIRST INCIDENCE    |     695          722 (T)      662          672         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.415      P=0.591N     P=0.664      P=0.560     |                                                    |
|POLY 3             |     P=0.492      P=0.526N     P=0.693      P=0.657     |                                                    |
|POLY 1.5           |     P=0.503      P=0.521N     P=0.693N     P=0.668     |                                                    |
|POLY 6             |     P=0.473      P=0.540N     P=0.686      P=0.636     |                                                    |
|LOGISTIC REGRESSION|     P=0.467      P=0.562N     P=0.688      P=0.630     |                                                    |
|COCH-ARM / FISHERS |     P=0.518      P=0.523N     P=0.691N     P=0.676     |                                                    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 50
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          580          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.556      (e)          P=0.237      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.554      (e)          P=0.238      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.572      (e)          P=0.239      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.522      (e)          P=0.235      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.603      (e)          P=0.235      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.4%         0.0%        |0.0%         0.0%         4.6%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    1/25 (4%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          722 (T)      ---         |---          ---          707          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.656      (e)          P=0.500      (e)         |P=0.539      (e)          P=0.226      (e)          |
|POLY 3             |     P=0.664      (e)          P=0.499      (e)         |P=0.541      (e)          P=0.235      (e)          |
|POLY 1.5           |     P=0.677      (e)          P=0.500      (e)         |P=0.565      (e)          P=0.236      (e)          |
|POLY 6             |     P=0.640      (e)          P=0.494      (e)         |P=0.505      (e)          P=0.233      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.500      (e)         |P=0.558      (e)          P=0.232      (e)          |
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.595      (e)          P=0.247      (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 51
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         2.4%         0.0%        |4.5%         2.2%         2.3%         2.5%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    1/25 (4%)    0/16 (0%)   |1/32 (3%)    1/37 (3%)    1/29 (3%)    1/26 (4%)    |
|FIRST INCIDENCE    |     ---          722 (T)      722 (T)      ---         |717          729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.674N     P=0.455      P=0.500      (e)         |P=0.502N     P=0.454N     P=0.537N     P=0.582N     |
|POLY 3             |     P=0.613N     P=0.497      P=0.499      (e)         |P=0.432N     P=0.490N     P=0.504N     P=0.530N     |
|POLY 1.5           |     P=0.604N     P=0.500      P=0.500      (e)         |P=0.422N     P=0.494N     P=0.502N     P=0.517N     |
|POLY 6             |     P=0.630N     P=0.488      P=0.494      (e)         |P=0.445N     P=0.484N     P=0.508N     P=0.550N     |
|LOGISTIC REGRESSION|     (e)          P=0.455      P=0.500      (e)         |P=0.498N     P=0.470N     P=0.514N     P=0.580N     |
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.409N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |6.8%         2.2%         0.0%         2.4%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |2/32 (6%)    1/37 (3%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |717          729 (T)      ---          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.254N     P=0.260N     P=0.142N     P=0.376N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.207N     P=0.295N     P=0.121N     P=0.332N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.204N     P=0.299N     P=0.120N     P=0.320N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.211N     P=0.288N     P=0.122N     P=0.350N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.206N     P=0.270N     P=0.126N     P=0.313N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.200N     P=0.309N     P=0.121N     P=0.309N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 52
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/48 (2%)    0/50 (0%)    1/49 (2%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         0.0%         2.7%        |2.3%         0.0%         4.5%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    0/25 (0%)    1/16 (6%)   |1/32 (3%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          722 (T)      ---          722 (T)     |729 (T)      ---          624          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.326      P=0.455      (e)          P=0.411     |P=0.517N     P=0.471N     P=0.487      P=0.541N     |
|POLY 3             |     P=0.387      P=0.494      (e)          P=0.485     |P=0.494N     P=0.494N     P=0.500      P=0.517N     |
|POLY 1.5           |     P=0.397      P=0.497      (e)          P=0.492     |P=0.480N     P=0.496N     P=0.501      P=0.509N     |
|POLY 6             |     P=0.369      P=0.486      (e)          P=0.471     |P=0.514N     P=0.490N     P=0.500      P=0.528N     |
|LOGISTIC REGRESSION|     (e)          P=0.455      (e)          P=0.411     |P=0.452N     (e)          P=0.500      (e)          |
|COCH-ARM / FISHERS |     P=0.407      P=0.495      (e)          P=0.500     |P=0.461N     P=0.500N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/49 (29%)  11/48 (23%)  9/50 (18%)   12/49 (24%) |2/50 (4%)    3/50 (6%)    3/50 (6%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     33.8%        27.3%        21.8%        30.6%       |4.5%         6.5%         6.7%         9.8%         |
|TERMINAL (d)       |     9/25 (36%)   5/20 (25%)   7/25 (28%)   4/16 (25%)  |1/32 (3%)    2/37 (5%)    0/29 (0%)    2/26 (8%)    |
|FIRST INCIDENCE    |     574          642          632          444         |667          546          573          672          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.406      P=0.534N     P=0.183N     P=0.399     |P=0.181      P=0.541      P=0.479      P=0.246      |
|POLY 3             |     P=0.430N     P=0.346N     P=0.162N     P=0.476N    |P=0.230      P=0.517      P=0.499      P=0.299      |
|POLY 1.5           |     P=0.406N     P=0.335N     P=0.155N     P=0.442N    |P=0.249      P=0.511      P=0.500      P=0.316      |
|POLY 6             |     P=0.475N     P=0.381N     P=0.184N     P=0.540N    |P=0.205      P=0.526      P=0.497      P=0.275      |
|LOGISTIC REGRESSION|     P=0.490N     P=0.370N     P=0.169N     P=0.507N    |P=0.281      P=0.480      P=0.500      P=0.286      |
|COCH-ARM / FISHERS |     P=0.378N     P=0.343N     P=0.157N     P=0.410N    |P=0.273      P=0.500      P=0.500      P=0.339      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 53
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/48 (2%)    0/50 (0%)    1/49 (2%)   |2/50 (4%)    4/50 (8%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.5%         0.0%         2.7%        |4.4%         8.4%         0.0%         4.9%         |
|TERMINAL (d)       |     1/25 (4%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    2/26 (8%)    |
|FIRST INCIDENCE    |     722 (T)      444          ---          685         |493          488          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.649      P=0.745      P=0.500N     P=0.678     |P=0.475N     P=0.356      P=0.232N     P=0.630      |
|POLY 3             |     P=0.618N     P=0.759      P=0.497N     P=0.745     |P=0.434N     P=0.360      P=0.244N     P=0.656      |
|POLY 1.5           |     P=0.616N     P=0.760      P=0.496N     P=0.752     |P=0.421N     P=0.351      P=0.241N     P=0.673      |
|POLY 6             |     P=0.621N     P=0.752      P=0.503N     P=0.730     |P=0.453N     P=0.374      P=0.248N     P=0.632      |
|LOGISTIC REGRESSION|     P=0.591N     P=0.724      (e)          P=0.726     |P=0.297N     P=0.210      P=0.263N     P=0.670N     |
|COCH-ARM / FISHERS |     P=0.614N     P=0.747      P=0.495N     P=0.753N    |P=0.404N     P=0.339      P=0.247N     P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    1/37 (3%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          666          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.457N     P=0.261      (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.414N     P=0.245      (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.409N     P=0.242      (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.421N     P=0.250      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.412N     P=0.236      (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 54
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    2/48 (4%)    1/50 (2%)    0/49 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     9.5%         5.0%         2.4%         0.0%        |0.0%         2.2%         4.5%         2.5%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     309          604          589          ---         |---          546          549          711          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.039N*    P=0.378N     P=0.195N     P=0.087N    |P=0.336      P=0.504      P=0.237      P=0.448      |
|POLY 3             |     P=0.033N*    P=0.364N     P=0.184N     P=0.077N    |P=0.321      P=0.509      P=0.240      P=0.483      |
|POLY 1.5           |     P=0.031N*    P=0.354N     P=0.179N     P=0.069N    |P=0.341      P=0.505      P=0.239      P=0.491      |
|POLY 6             |     P=0.036N*    P=0.385N     P=0.194N     P=0.090N    |P=0.294      P=0.513      P=0.240      P=0.472      |
|LOGISTIC REGRESSION|     P=0.020N*    P=0.438N     P=0.193N     P=0.044N*   |P=0.477      P=0.381      P=0.178      P=0.472      |
|COCH-ARM / FISHERS |     P=0.029N*    P=0.349N     P=0.175N     P=0.059N    |P=0.366      P=0.500      P=0.247      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         5.3%        |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          685         |---          ---          ---          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.032 *    (e)          (e)          P=0.167     |P=0.195      (e)          (e)          P=0.491      |
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.221     |P=0.188      (e)          (e)          P=0.485      |
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.229     |P=0.192      (e)          (e)          P=0.492      |
|POLY 6             |     P=0.041 *    (e)          (e)          P=0.207     |P=0.181      (e)          (e)          P=0.476      |
|LOGISTIC REGRESSION|     P=0.036 *    (e)          (e)          P=0.200     |P=0.261      (e)          (e)          P=0.551      |
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.247     |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 55
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    2/49 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         5.3%        |2.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          523         |503          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.033 *    (e)          (e)          P=0.189     |P=0.306N     P=0.496N     P=0.496N     P=0.500N     |
|POLY 3             |     P=0.042 *    (e)          (e)          P=0.219     |P=0.298N     P=0.497N     P=0.505N     P=0.520N     |
|POLY 1.5           |     P=0.043 *    (e)          (e)          P=0.226     |P=0.302N     P=0.498N     P=0.503N     P=0.511N     |
|POLY 6             |     P=0.041 *    (e)          (e)          P=0.207     |P=0.292N     P=0.495N     P=0.509N     P=0.532N     |
|LOGISTIC REGRESSION|     P=0.051      (e)          (e)          P=0.242     |P=0.239N     P=0.682N     P=0.653N     P=0.424N     |
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.242     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    0/50 (0%)    8/49 (16%)  |2/50 (4%)    1/50 (2%)    3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.8%         0.0%         0.0%         20.0%       |4.4%         2.2%         6.7%         4.8%         |
|TERMINAL (d)       |     0/25 (0%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    1/37 (3%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     595          ---          ---          194         |503          729 (T)      496          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.259N     P=0.253N     P=0.032 *   |P=0.430      P=0.475N     P=0.505      P=0.648      |
|POLY 3             |     P<0.001 **   P=0.247N     P=0.241N     P=0.037 *   |P=0.450      P=0.496N     P=0.495      P=0.661      |
|POLY 1.5           |     P<0.001 **   P=0.242N     P=0.238N     P=0.040 *   |P=0.471      P=0.498N     P=0.498      P=0.675      |
|POLY 6             |     P<0.001 **   P=0.259N     P=0.249N     P=0.031 *   |P=0.420      P=0.494N     P=0.490      P=0.641      |
|LOGISTIC REGRESSION|     P=0.002 **   P=0.246N     P=0.239N     P=0.052     |P=0.586N     P=0.561N     P=0.470      P=0.623N     |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.253N     P=0.247N     P=0.043 *   |P=0.500      P=0.500N     P=0.500      P=0.691N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 56
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    10/49 (20%)  3/50 (6%)    4/49 (8%)   |3/50 (6%)    3/50 (6%)    4/50 (8%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     4.8%         24.0%        7.2%         10.3%       |6.7%         6.4%         8.9%         9.6%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    0/25 (0%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     595          538          609          194         |667          488          605          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.522      P=0.013 *    P=0.497      P=0.266     |P=0.286      P=0.640N     P=0.481      P=0.387      |
|POLY 3             |     P=0.536N     P=0.012 *    P=0.499      P=0.300     |P=0.336      P=0.639N     P=0.499      P=0.461      |
|POLY 1.5           |     P=0.510N     P=0.013 *    P=0.502      P=0.316     |P=0.359      P=0.648N     P=0.501      P=0.478      |
|POLY 6             |     P=0.540      P=0.010 *    P=0.490      P=0.271     |P=0.307      P=0.628N     P=0.497      P=0.436      |
|LOGISTIC REGRESSION|     P=0.460N     P=0.014 *    P=0.491      P=0.366     |P=0.502      P=0.591      P=0.499      P=0.529      |
|COCH-ARM / FISHERS |     P=0.493N     P=0.013 *    P=0.500      P=0.329     |P=0.389      P=0.661N     P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    7/49 (14%)   7/50 (14%)   11/49 (22%) |2/50 (4%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.4%         17.1%        16.3%        28.0%       |4.5%         4.3%         4.5%         2.5%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    1/25 (4%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     625          604          538          598         |588          546          586          711          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.002 **   P=0.025 *    P=0.037 *    P<0.001 **  |P=0.448N     P=0.673N     P=0.672      P=0.571N     |
|POLY 3             |     P=0.002 **   P=0.027 *    P=0.033 *    P<0.001 **  |P=0.412N     P=0.682N     P=0.691      P=0.533N     |
|POLY 1.5           |     P=0.003 **   P=0.029 *    P=0.032 *    P<0.001 **  |P=0.395N     P=0.687N     P=0.693      P=0.519N     |
|POLY 6             |     P=0.002 **   P=0.024 *    P=0.033 *    P<0.001 **  |P=0.436N     P=0.676N     P=0.688      P=0.555N     |
|LOGISTIC REGRESSION|     P=0.004 **   P=0.031 *    P=0.030 *    P=0.002 **  |P=0.307N     P=0.645      P=0.688      P=0.486N     |
|COCH-ARM / FISHERS |     P=0.004 **   P=0.028 *    P=0.030 *    P=0.002 **  |P=0.373N     P=0.691N     P=0.691N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 57
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  17/49 (35%)  12/50 (24%)  12/49 (24%) |6/50 (12%)   9/50 (18%)   9/50 (18%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     33.2%        37.8%        27.1%        28.8%       |13.2%        18.7%        19.6%        16.3%        |
|TERMINAL (d)       |     1/25 (4%)    1/20 (5%)    1/25 (4%)    0/16 (0%)   |1/32 (3%)    1/37 (3%)    1/29 (3%)    1/26 (4%)    |
|FIRST INCIDENCE    |     473          444          585          444         |636          488          580          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.374N     P=0.326      P=0.383N     P=0.534N    |P=0.340      P=0.351      P=0.282      P=0.369      |
|POLY 3             |     P=0.270N     P=0.407      P=0.344N     P=0.416N    |P=0.442      P=0.332      P=0.295      P=0.458      |
|POLY 1.5           |     P=0.242N     P=0.412      P=0.332N     P=0.383N    |P=0.473      P=0.314      P=0.293      P=0.477      |
|POLY 6             |     P=0.318N     P=0.378      P=0.366N     P=0.477N    |P=0.398      P=0.355      P=0.298      P=0.430      |
|LOGISTIC REGRESSION|     P=0.155N     P=0.363      P=0.333N     P=0.304N    |P=0.450N     P=0.231      P=0.288      P=0.565      |
|COCH-ARM / FISHERS |     P=0.209N     P=0.388      P=0.326N     P=0.349N    |P=0.513      P=0.288      P=0.288      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    2/50 (4%)    8/49 (16%)  |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         4.9%         21.0%       |0.0%         0.0%         4.5%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    2/20 (10%)   0/25 (0%)    3/16 (19%)  |0/32 (0%)    0/37 (0%)    1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          722 (T)      679          622         |---          ---          561          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.190      P=0.218      P<0.001 **  |P=0.567      (e)          P=0.229      (e)          |
|POLY 3             |     P<0.001 **   P=0.229      P=0.237      P=0.002 **  |P=0.539      (e)          P=0.237      (e)          |
|POLY 1.5           |     P<0.001 **   P=0.233      P=0.238      P=0.003 **  |P=0.565      (e)          P=0.238      (e)          |
|POLY 6             |     P<0.001 **   P=0.219      P=0.232      P=0.002 **  |P=0.503      (e)          P=0.236      (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.190      P=0.234      P=0.002 **  |P=0.635      (e)          P=0.228      (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.242      P=0.247      P=0.003 **  |P=0.595      (e)          P=0.247      (e)          |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 58
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    5/49 (10%)   1/50 (2%)    1/49 (2%)   |1/50 (2%)    1/50 (2%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.8%         12.3%        2.4%         2.7%        |2.2%         2.2%         6.7%         0.0%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     692          607          700          697         |503          546          573          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.275N     P=0.176      P=0.534N     P=0.628N    |P=0.450N     P=0.756N     P=0.303      P=0.500N     |
|POLY 3             |     P=0.219N     P=0.209      P=0.503N     P=0.535N    |P=0.462N     P=0.754N     P=0.301      P=0.520N     |
|POLY 1.5           |     P=0.207N     P=0.212      P=0.500N     P=0.521N    |P=0.439N     P=0.757N     P=0.304      P=0.511N     |
|POLY 6             |     P=0.241N     P=0.198      P=0.513N     P=0.558N    |P=0.494N     P=0.750N     P=0.299      P=0.532N     |
|LOGISTIC REGRESSION|     P=0.211N     P=0.208      P=0.506N     P=0.549N    |P=0.302N     P=0.639      P=0.276      P=0.424N     |
|COCH-ARM / FISHERS |     P=0.198N     P=0.210      P=0.500N     P=0.508N    |P=0.409N     P=0.753N     P=0.309      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    0/49 (0%)    0/48 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         0.0%         0.0%        |                                                    |
|TERMINAL (d)       |     1/25 (4%)    0/20 (0%)    0/25 (0%)    0/16 (0%)   |                                                    |
|FIRST INCIDENCE    |     695          ---          ---          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.142N     P=0.293N     P=0.251N     P=0.334N    |                                                    |
|POLY 3             |     P=0.111N     P=0.240N     P=0.237N     P=0.258N    |                                                    |
|POLY 1.5           |     P=0.113N     P=0.236N     P=0.236N     P=0.250N    |                                                    |
|POLY 6             |     P=0.106N     P=0.250N     P=0.241N     P=0.272N    |                                                    |
|LOGISTIC REGRESSION|     P=0.128N     P=0.259N     P=0.243N     P=0.283N    |                                                    |
|COCH-ARM / FISHERS |     P=0.116N     P=0.247N     P=0.247N     P=0.253N    |                                                    |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 59
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/49 (24%)  8/49 (16%)   9/49 (18%)   5/48 (10%)  |                                                    |
|POLY-3 ADJUSTED (b)|     26.5%        19.4%        20.6%        12.9%       |                                                    |
|TERMINAL (d)       |     4/25 (16%)   3/20 (15%)   1/25 (4%)    0/16 (0%)   |                                                    |
|FIRST INCIDENCE    |     309          553          486          520         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.117N     P=0.309N     P=0.326N     P=0.117N    |                                                    |
|POLY 3             |     P=0.089N     P=0.295N     P=0.340N     P=0.098N    |                                                    |
|POLY 1.5           |     P=0.078N     P=0.264N     P=0.331N     P=0.081N    |                                                    |
|POLY 6             |     P=0.105N     P=0.344N     P=0.352N     P=0.123N    |                                                    |
|LOGISTIC REGRESSION|     P=0.034N*    P=0.264N     P=0.351N     P=0.032N*   |                                                    |
|COCH-ARM / FISHERS |     P=0.061N     P=0.226N     P=0.312N     P=0.059N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Ectopic Parathyroid Gland                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/48 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.6%        |4.5%         2.2%         2.3%         4.9%         |
|TERMINAL (d)       |     0/25 (0%)    0/19 (0%)    0/23 (0%)    0/16 (0%)   |2/32 (6%)    1/37 (3%)    1/29 (3%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          562         |729 (T)      729 (T)      729 (T)      639          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.189      (e)          (e)          P=0.486     |P=0.463      P=0.449N     P=0.535N     P=0.617      |
|POLY 3             |     P=0.194      (e)          (e)          P=0.488     |P=0.526      P=0.489N     P=0.504N     P=0.668      |
|POLY 1.5           |     P=0.197      (e)          (e)          P=0.494     |P=0.538      P=0.494N     P=0.501N     P=0.679      |
|POLY 6             |     P=0.189      (e)          (e)          P=0.478     |P=0.509      P=0.483N     P=0.508N     P=0.652      |
|LOGISTIC REGRESSION|     P=0.228      (e)          (e)          P=0.522     |P=0.525      P=0.449N     P=0.535N     P=0.683      |
|COCH-ARM / FISHERS |     P=0.200      (e)          (e)          P=0.500     |P=0.556      P=0.500N     P=0.500N     P=0.691N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 60
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland                                                                                                                    |
|     Ultimobranchial Cyst                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    1/49 (2%)   |0/50 (0%)    3/50 (6%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         0.0%         2.6%        |0.0%         6.5%         0.0%         2.4%         |
|TERMINAL (d)       |     0/25 (0%)    1/20 (5%)    0/25 (0%)    0/16 (0%)   |0/32 (0%)    2/37 (5%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     309          722 (T)      ---          523         |---          695          ---          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.651N     P=0.736      P=0.504N     P=0.756     |P=0.578      P=0.147      (e)          P=0.500      |
|POLY 3             |     P=0.625N     P=0.753      P=0.506N     P=0.743     |P=0.611      P=0.125      (e)          P=0.486      |
|POLY 1.5           |     P=0.623N     P=0.758      P=0.503N     P=0.750     |P=0.622      P=0.122      (e)          P=0.492      |
|POLY 6             |     P=0.628N     P=0.742      P=0.511N     P=0.730     |P=0.594      P=0.128      (e)          P=0.477      |
|LOGISTIC REGRESSION|     P=0.643      P=0.669      P=0.455N     P=0.556     |P=0.598N     P=0.128      (e)          P=0.574      |
|COCH-ARM / FISHERS |     P=0.621N     P=0.753N     P=0.500N     P=0.747     |P=0.634      P=0.121      (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   3/50 (6%)    3/49 (6%)   |16/50 (32%)  17/50 (34%)  13/50 (26%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     16.5%        12.1%        7.2%         7.8%        |35.6%        36.8%        28.6%        24.3%        |
|TERMINAL (d)       |     2/25 (8%)    3/20 (15%)   1/25 (4%)    2/16 (13%)  |14/32 (44%)  15/37 (41%)  9/29 (31%)   9/26 (35%)   |
|FIRST INCIDENCE    |     388          598          596          598         |622          650          521          583          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.195N     P=0.492N     P=0.185N     P=0.323N    |P=0.236N     P=0.486N     P=0.423N     P=0.280N     |
|POLY 3             |     P=0.125N     P=0.398N     P=0.164N     P=0.196N    |P=0.110N     P=0.540      P=0.312N     P=0.180N     |
|POLY 1.5           |     P=0.118N     P=0.384N     P=0.160N     P=0.179N    |P=0.089N     P=0.524      P=0.317N     P=0.153N     |
|POLY 6             |     P=0.139N     P=0.432N     P=0.174N     P=0.229N    |P=0.147N     P=0.565      P=0.309N     P=0.226N     |
|LOGISTIC REGRESSION|     P=0.111N     P=0.379N     P=0.160N     P=0.167N    |P=0.137N     P=0.573      P=0.339N     P=0.255N     |
|COCH-ARM / FISHERS |     P=0.111N     P=0.380N     P=0.159N     P=0.167N    |P=0.068N     P=0.500      P=0.330N     P=0.127N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 61
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicle                                                                                                          |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         2.4%         5.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/25 (4%)    1/20 (5%)    0/25 (0%)    1/16 (6%)   |0/32 (0%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     722 (T)      722 (T)      662          651         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.263      P=0.712      P=0.754      P=0.380     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.331      P=0.758      P=0.761      P=0.477     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.339      P=0.760N     P=0.760N     P=0.487     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.318      P=0.748      P=0.757      P=0.457     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.315      P=0.712      P=0.760      P=0.453     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.344      P=0.753N     P=0.753N     P=0.492     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   1/50 (2%)    2/49 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.4%         12.3%        2.4%         5.2%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/25 (4%)    4/20 (20%)   0/25 (0%)    2/16 (13%)  |1/32 (3%)    0/37 (0%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |     722 (T)      700          640          722 (T)     |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.515      P=0.058      P=0.757      P=0.345     |P=0.335N     P=0.471N     P=0.520N     P=0.541N     |
|POLY 3             |     P=0.555N     P=0.097      P=0.761N     P=0.475     |P=0.300N     P=0.494N     P=0.502N     P=0.517N     |
|POLY 1.5           |     P=0.541N     P=0.101      P=0.759N     P=0.486     |P=0.303N     P=0.496N     P=0.501N     P=0.509N     |
|POLY 6             |     P=0.583N     P=0.086      P=0.758      P=0.453     |P=0.294N     P=0.490N     P=0.504N     P=0.528N     |
|LOGISTIC REGRESSION|     P=0.574      P=0.052      P=0.762      P=0.345     |P=0.335N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.532N     P=0.102      P=0.753N     P=0.492     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 62
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/47 (0%)    1/50 (2%)    1/49 (2%)   |0/50 (0%)    3/50 (6%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     9.7%         0.0%         2.4%         2.7%        |0.0%         6.6%         2.3%         4.9%         |
|TERMINAL (d)       |     2/25 (8%)    0/20 (0%)    0/25 (0%)    1/16 (6%)   |0/32 (0%)    3/37 (8%)    1/29 (3%)    1/26 (4%)    |
|FIRST INCIDENCE    |     692          ---          529          722 (T)     |---          729 (T)      729 (T)      584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.230N     P=0.101N     P=0.196N     P=0.329N    |P=0.257      P=0.147      P=0.480      P=0.212      |
|POLY 3             |     P=0.165N     P=0.069N     P=0.177N     P=0.210N    |P=0.305      P=0.124      P=0.498      P=0.221      |
|POLY 1.5           |     P=0.165N     P=0.068N     P=0.176N     P=0.198N    |P=0.319      P=0.122      P=0.499      P=0.228      |
|POLY 6             |     P=0.165N     P=0.075N     P=0.182N     P=0.233N    |P=0.285      P=0.127      P=0.496      P=0.211      |
|LOGISTIC REGRESSION|     P=0.173N     P=0.080N     P=0.179N     P=0.259N    |P=0.304      P=0.147      P=0.480      P=0.255      |
|COCH-ARM / FISHERS |     P=0.164N     P=0.066N     P=0.181N     P=0.187N    |P=0.337      P=0.121      P=0.500      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         2.2%         2.3%         4.8%         |
|TERMINAL (d)       |                                                        |0/32 (0%)    0/37 (0%)    0/29 (0%)    1/26 (4%)    |
|FIRST INCIDENCE    |                                                        |---          488          699          457          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.126      P=0.504      P=0.511      P=0.217      |
|POLY 3             |                                                        |P=0.137      P=0.509      P=0.498      P=0.222      |
|POLY 1.5           |                                                        |P=0.144      P=0.506      P=0.499      P=0.229      |
|POLY 6             |                                                        |P=0.126      P=0.514      P=0.497      P=0.212      |
|LOGISTIC REGRESSION|                                                        |P=0.242      P=0.289      P=0.499      P=0.287      |
|COCH-ARM / FISHERS |                                                        |P=0.153      P=0.500      P=0.500      P=0.247      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 05                                            Page 63
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |6/50 (12%)   0/50 (0%)    5/50 (10%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|                                                        |13.4%        0.0%         11.2%        16.9%        |
|TERMINAL (d)       |                                                        |4/32 (13%)   0/37 (0%)    1/29 (3%)    5/26 (19%)   |
|FIRST INCIDENCE    |                                                        |671          ---          665          608          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.091      P=0.013N*    P=0.526N     P=0.355      |
|POLY 3             |                                                        |P=0.142      P=0.014N*    P=0.504N     P=0.442      |
|POLY 1.5           |                                                        |P=0.156      P=0.015N*    P=0.501N     P=0.468      |
|POLY 6             |                                                        |P=0.125      P=0.013N*    P=0.509N     P=0.404      |
|LOGISTIC REGRESSION|                                                        |P=0.147      P=0.016N*    P=0.506N     P=0.430      |
|COCH-ARM / FISHERS |                                                        |P=0.179      P=0.013N*    P=0.500N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        100 PPM      200 PPM      400 PPM     |0 PPM        100 PPM      200 PPM      400 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         4.4%         0.0%         2.4%         |
|TERMINAL (d)       |                                                        |0/32 (0%)    2/37 (5%)    0/29 (0%)    0/26 (0%)    |
|FIRST INCIDENCE    |                                                        |---          729 (T)      ---          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.490      P=0.271      (e)          P=0.491      |
|POLY 3             |                                                        |P=0.516      P=0.244      (e)          P=0.485      |
|POLY 1.5           |                                                        |P=0.526      P=0.241      (e)          P=0.492      |
|POLY 6             |                                                        |P=0.501      P=0.248      (e)          P=0.476      |
|LOGISTIC REGRESSION|                                                        |P=0.553      P=0.271      (e)          P=0.551      |
|COCH-ARM / FISHERS |                                                        |P=0.539      P=0.247      (e)          P=0.500      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).