TDMS Study 55301-06 Pathology Tables
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
Facility: TSI Mason Research
Chemical CAS #: 110-86-1
Lock Date: 12/13/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 26 27 30 33
Moribund Sacrifice 2 9 9 10
Survivors
Terminal Sacrifice 22 14 11 7
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Foreign Body 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Ulcer 1 (2%)
Muscularis, Degeneration 1 (2%)
Intestine Large, Colon (35) (39) (36) (33)
Mineralization 1 (3%) 1 (3%)
Parasite Metazoan 1 (3%)
Intestine Large, Rectum (42) (42) (41) (40)
Hemorrhage 1 (2%)
Mineralization 1 (2%)
Parasite Metazoan 1 (3%)
Ulcer 1 (3%)
Intestine Large, Cecum (32) (37) (29) (27)
Congestion 1 (3%)
Edema 1 (3%)
Hemorrhage 1 (3%) 2 (5%) 1 (3%)
Inflammation, Acute 2 (5%) 2 (7%) 1 (4%)
Inflammation, Chronic 1 (3%) 1 (4%)
Ulcer 2 (5%) 2 (7%)
Artery, Mineralization 1 (3%)
Intestine Small, Jejunum (37) (36) (34) (35)
Inflammation, Chronic 1 (3%)
Liver (50) (50) (50) (50)
Angiectasis 5 (10%) 9 (18%) 2 (4%)
Basophilic Focus 2 (4%)
Cholangiofibrosis 1 (2%)
Clear Cell Focus 15 (30%) 7 (14%) 8 (16%) 8 (16%)
Congestion 19 (38%) 12 (24%) 6 (12%) 17 (34%)
Degeneration, Cystic 7 (14%) 13 (26%) 9 (18%) 5 (10%)
Eosinophilic Focus 14 (28%) 12 (24%) 4 (8%) 2 (4%)
Fibrosis 1 (2%) 5 (10%) 26 (52%) 31 (62%)
Hemorrhage 1 (2%) 1 (2%) 5 (10%) 3 (6%)
Hepatodiaphragmatic Nodule 2 (4%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hypertrophy 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 2 (4%)
Inflammation, Acute 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Mineralization 1 (2%) 3 (6%) 3 (6%)
Mixed Cell Focus 1 (2%) 1 (2%) 1 (2%)
Necrosis 6 (12%) 7 (14%) 6 (12%) 2 (4%)
Pigmentation 6 (12%) 15 (30%) 34 (68%) 42 (84%)
Regeneration 2 (4%)
Tension Lipidosis 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 18 (36%) 18 (36%) 12 (24%) 15 (30%)
Artery, Mineralization 1 (2%)
Bile Duct, Cyst 2 (4%) 3 (6%)
Bile Duct, Dilatation 2 (4%)
Bile Duct, Hyperplasia 31 (62%) 33 (66%) 30 (60%) 27 (54%)
Centrilobular, Cytomegaly 1 (2%) 1 (2%) 1 (2%)
Centrilobular, Degeneration 1 (2%) 15 (30%) 25 (50%) 33 (66%)
Centrilobular, Hypertrophy 1 (2%)
Centrilobular, Necrosis 5 (10%) 6 (12%) 4 (8%) 23 (46%)
Hepatocyte, Atrophy 2 (4%) 1 (2%) 1 (2%)
Oval Cell, Hyperplasia 1 (2%)
Periportal, Fibrosis 5 (10%) 7 (14%)
Sinusoid, Congestion 1 (2%)
Mesentery (7) (1) (2) (2)
Mineralization 1 (14%)
Artery, Inflammation 5 (71%) 1 (100%) 1 (50%)
Artery, Mineralization 2 (29%)
Fat, Necrosis 1 (14%) 1 (50%)
Vein, Thrombosis 2 (100%)
Oral Mucosa (5) (1) (1)
Hyperplasia, Squamous 1 (100%) 1 (100%)
Inflammation, Suppurative 3 (60%)
Pancreas (46) (50) (50) (49)
Atrophy 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Basophilic Focus 1 (2%)
Edema 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 18 (39%) 18 (36%) 8 (16%) 8 (16%)
Necrosis 1 (2%)
Acinus, Hyperplasia 1 (2%) 1 (2%)
Artery, Inflammation 3 (7%) 5 (10%) 3 (6%)
Artery, Mineralization 2 (4%) 6 (12%) 1 (2%)
Duct, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Salivary Glands (48) (49) (47) (48)
Atrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Acute 1 (2%)
Artery, Mineralization 2 (4%) 3 (6%)
Duct, Cyst 1 (2%) 1 (2%)
Stomach, Forestomach (49) (50) (50) (49)
Cyst 1 (2%) 2 (4%)
Erosion 1 (2%)
Fibrosis 1 (2%)
Foreign Body 1 (2%) 2 (4%)
Hemorrhage 1 (2%)
Hyperplasia, Squamous 2 (4%) 13 (26%) 11 (22%) 10 (20%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 3 (6%) 5 (10%) 3 (6%) 1 (2%)
Ulcer 2 (4%) 4 (8%) 3 (6%) 4 (8%)
Ulcer, Chronic 1 (2%)
Stomach, Glandular (49) (50) (48) (48)
Erosion 3 (6%) 3 (6%) 2 (4%) 4 (8%)
Fibrosis 1 (2%)
Hemorrhage 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 8 (16%) 25 (50%) 16 (33%) 6 (13%)
Ulcer 1 (2%)
Artery, Mineralization 1 (2%) 1 (2%)
Serosa, Edema 1 (2%)
Tooth (2) (2) (4) (3)
Peridontal Tissue, Inflammation, Chronic 1 (33%)
Peridontal Tissue, Inflammation, Chronic
Active 1 (50%) 1 (33%)
Peridontal Tissue, Inflammation,
Granulomatous 1 (50%)
Peridontal Tissue, Inflammation, Suppurative 1 (50%) 1 (50%) 4 (100%) 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (8) (23) (12) (3)
Mineralization 6 (75%) 6 (26%) 1 (8%)
Aorta, Mineralization 7 (88%) 21 (91%) 10 (83%) 3 (100%)
Pulmonary Artery, Degeneration 1 (4%)
Pulmonary Artery, Mineralization 3 (38%) 3 (13%) 5 (42%) 2 (67%)
Heart (50) (50) (50) (50)
Cardiomyopathy 49 (98%) 49 (98%) 49 (98%) 47 (94%)
Inflammation, Chronic 1 (2%)
Mineralization 6 (12%) 17 (34%) 12 (24%) 3 (6%)
Thrombosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Artery, Inflammation 1 (2%)
Artery, Inflammation, Acute 1 (2%)
Artery, Mineralization 4 (8%) 15 (30%) 9 (18%) 2 (4%)
Artery, Thrombosis 1 (2%)
Atrium, Dilatation 1 (2%) 1 (2%)
Atrium, Thrombosis 4 (8%) 2 (4%) 5 (10%) 3 (6%)
Valve, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Angiectasis 1 (2%) 1 (2%)
Congestion 2 (4%) 1 (2%)
Degeneration 2 (4%)
Hemorrhage 3 (6%)
Hyperplasia 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Hypertrophy 2 (4%) 2 (4%) 2 (4%)
Mineralization 1 (2%)
Necrosis 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 17 (34%) 13 (26%) 12 (24%) 7 (14%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 3 (6%) 4 (8%) 2 (4%) 1 (2%)
Islets, Pancreatic (47) (50) (49) (49)
Hyperplasia 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Parathyroid Gland (48) (47) (48) (47)
Hyperplasia 16 (33%) 32 (68%) 29 (60%) 12 (26%)
Inflammation, Chronic 1 (2%)
Pituitary Gland (49) (49) (50) (50)
Angiectasis 1 (2%)
Congestion 2 (4%)
Cyst 17 (35%) 13 (27%) 18 (36%) 11 (22%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 13 (27%) 10 (20%) 7 (14%) 3 (6%)
Hypertrophy 1 (2%)
Pars Distalis, Hyperplasia 2 (4%) 1 (2%)
Thyroid Gland (49) (50) (48) (49)
Inflammation, Granulomatous 1 (2%)
C-Cell, Hyperplasia 1 (2%) 1 (2%)
Follicle, Cyst 2 (4%) 4 (8%) 5 (10%) 1 (2%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (48) (42) (45) (45)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Artery, Mineralization 1 (2%)
Epididymis (50) (49) (49) (50)
Arteriole, Mineralization 1 (2%)
Artery, Inflammation 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Preputial Gland (50) (48) (50) (50)
Atrophy 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 12 (24%) 9 (19%) 10 (20%) 3 (6%)
Duct, Cyst 49 (98%) 43 (90%) 46 (92%) 48 (96%)
Prostate (50) (49) (50) (50)
Fibrosis 2 (4%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 4 (8%) 4 (8%) 1 (2%) 2 (4%)
Inflammation, Acute 4 (8%) 1 (2%)
Inflammation, Chronic 3 (6%) 4 (8%) 5 (10%) 2 (4%)
Inflammation, Chronic Active 5 (10%) 5 (10%) 2 (4%) 2 (4%)
Artery, Mineralization 1 (2%)
Seminal Vesicle (49) (49) (50) (49)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Artery, Mineralization 1 (2%)
Testes (50) (49) (49) (50)
Atrophy 20 (40%) 20 (41%) 18 (37%) 9 (18%)
Congestion 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Mineralization 6 (12%) 2 (4%) 9 (18%) 4 (8%)
Artery, Inflammation 24 (48%) 24 (49%) 14 (29%) 11 (22%)
Artery, Mineralization 3 (6%) 2 (4%)
Interstitial Cell, Hyperplasia 3 (6%) 4 (8%) 7 (14%) 7 (14%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Erythroid Cell, Hyperplasia 1 (2%)
Myeloid Cell, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Lymph Node (31) (44) (38) (32)
Ectasia 2 (6%) 1 (2%)
Hemorrhage 2 (6%) 1 (2%)
Hyperplasia, Plasma Cell 2 (6%)
Iliac, Ectasia 5 (16%) 3 (7%) 3 (8%) 1 (3%)
Iliac, Hemorrhage 1 (3%) 2 (5%) 2 (5%) 3 (9%)
Iliac, Hyperplasia, Lymphoid 1 (2%) 2 (5%) 1 (3%)
Iliac, Hyperplasia, Plasma Cell 4 (9%) 2 (5%) 2 (6%)
Inguinal, Atrophy 1 (3%)
Inguinal, Ectasia 1 (3%) 1 (3%)
Inguinal, Hemorrhage 1 (2%) 1 (3%) 1 (3%)
Inguinal, Hyperplasia, Lymphoid 1 (3%)
Inguinal, Infiltration Cellular, Histiocyte 1 (3%)
Mediastinal, Atrophy 1 (2%)
Mediastinal, Congestion 1 (3%) 3 (7%) 2 (5%) 1 (3%)
Mediastinal, Ectasia 6 (19%) 12 (27%) 9 (24%) 6 (19%)
Mediastinal, Hemorrhage 8 (26%) 15 (34%) 10 (26%) 9 (28%)
Mediastinal, Hyperplasia, Lymphoid 1 (3%)
Mediastinal, Hyperplasia, Plasma Cell 2 (5%) 1 (3%) 1 (3%)
Pancreatic, Ectasia 2 (6%) 5 (11%) 1 (3%)
Pancreatic, Hemorrhage 4 (13%) 5 (11%) 4 (11%) 7 (22%)
Pancreatic, Hyperplasia, Lymphoid 2 (6%) 1 (2%) 4 (13%)
Pancreatic, Hyperplasia, Plasma Cell 1 (3%) 2 (5%) 2 (6%)
Pancreatic, Pigmentation 1 (3%)
Renal, Ectasia 15 (48%) 20 (45%) 16 (42%) 10 (31%)
Renal, Fibrosis 2 (5%)
Renal, Hemorrhage 10 (32%) 17 (39%) 19 (50%) 12 (38%)
Renal, Hyperplasia, Lymphoid 1 (3%) 2 (6%)
Renal, Hyperplasia, Plasma Cell 1 (2%) 6 (16%) 2 (6%)
Renal, Pigmentation 3 (8%)
Lymph Node, Mandibular (48) (49) (47) (48)
Congestion 5 (10%) 1 (2%) 4 (8%)
Ectasia 15 (31%) 8 (16%) 10 (21%) 10 (21%)
Hemorrhage 3 (6%) 1 (2%) 3 (6%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 4 (8%) 8 (16%) 6 (13%) 4 (8%)
Lymph Node, Mesenteric (46) (50) (50) (50)
Atrophy 6 (12%) 1 (2%) 2 (4%)
Ectasia 5 (11%) 6 (12%) 6 (12%) 5 (10%)
Hemorrhage 12 (26%) 14 (28%) 12 (24%) 12 (24%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%) 5 (10%)
Hyperplasia, Plasma Cell 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (49) (50) (49) (49)
Angiectasis 1 (2%)
Atrophy 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Congestion 1 (2%) 1 (2%)
Fibrosis 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Necrosis 1 (2%)
Artery, Mineralization 1 (2%) 1 (2%)
Thymus (48) (49) (49) (50)
Atrophy 15 (31%) 29 (59%) 28 (57%) 24 (48%)
Cyst 5 (10%) 6 (12%) 4 (8%) 6 (12%)
Ectopic Parathyroid Gland 3 (6%) 5 (10%) 1 (2%) 1 (2%)
Ectopic Thyroid 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 8 (17%) 6 (12%) 8 (16%) 14 (28%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Squamous 2 (4%)
Artery, Mineralization 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (46) (44) (46)
Cyst 2 (4%) 1 (2%)
Hyperplasia 4 (8%) 2 (5%) 4 (9%)
Artery, Mineralization 3 (6%) 5 (11%)
Duct, Dilatation 6 (13%) 7 (15%) 5 (11%) 4 (9%)
Skin (50) (50) (50) (50)
Cyst 1 (2%) 2 (4%) 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 2 (4%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 2 (4%)
Hair Follicle, Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 10 (20%) 21 (42%) 16 (32%) 6 (12%)
Inflammation, Chronic Active 1 (2%)
Osteosclerosis 1 (2%)
Cartilage, Degeneration 1 (2%)
Cranium, Fibrous Osteodystrophy 10 (20%) 15 (30%) 13 (26%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Joint, Arthrosis 1 (2%)
Joint, Fibrosis 1 (2%)
Joint, Inflammation, Chronic 1 (2%) 1 (2%)
Mandible, Hyperplasia 1 (2%)
Metacarpal, Inflammation, Chronic Active 1 (2%)
Metatarsal, Hyperplasia 1 (2%)
Metatarsal, Inflammation, Chronic Active 1 (2%)
Periosteum, Hyperplasia 1 (2%)
Rib, Callus 1 (2%)
Vertebra, Fibrous Osteodystrophy 4 (8%) 2 (4%)
Vertebra, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Degeneration 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 1 (2%) 1 (2%)
Peripheral Nerve (1) (4) (2) (5)
Degeneration 1 (100%)
Mineralization 2 (50%) 2 (100%)
Radicular Neuropathy 4 (100%) 1 (50%) 2 (40%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 4 (8%) 2 (4%) 4 (8%)
Edema 2 (4%)
Hemorrhage 2 (4%) 1 (2%) 10 (20%) 7 (14%)
Inflammation, Acute 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Granulomatous 4 (8%) 1 (2%) 5 (10%) 2 (4%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%)
Alveolar Epithelium, Hypertrophy 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 8 (16%) 5 (10%) 4 (8%)
Alveolus, Mineralization 2 (4%)
Artery, Mineralization 2 (4%) 3 (6%)
Bronchus, Inflammation, Acute 1 (2%)
Bronchus, Mineralization 1 (2%)
Interstitium, Fibrosis 4 (8%) 6 (12%) 4 (8%) 1 (2%)
Interstitium, Inflammation, Chronic 2 (4%)
Nose (50) (50) (50) (50)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Erosion 1 (2%)
Foreign Body 11 (22%) 4 (8%) 6 (12%) 1 (2%)
Hemorrhage 3 (6%) 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Acute 7 (14%) 7 (14%) 4 (8%) 2 (4%)
Inflammation, Chronic 7 (14%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 4 (8%) 6 (12%) 5 (10%) 6 (12%)
Metaplasia, Squamous 1 (2%) 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Ulcer 2 (4%)
Artery, Thrombosis 1 (2%)
Olfactory Epithelium, Hyperplasia 1 (2%)
Olfactory Epithelium, Metaplasia 1 (2%)
Respiratory Epithelium, Hyperplasia 20 (40%) 9 (18%) 12 (24%) 15 (30%)
Respiratory Epithelium, Metaplasia 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (50) (50) (50) (50)
Cyst 1 (2%)
Foreign Body 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Ulcer 1 (100%)
Harderian Gland (1) (4) (1)
Inflammation, Chronic 1 (100%)
Lacrimal Gland (1)
Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Congestion 4 (8%) 2 (4%)
Cyst 21 (42%) 31 (62%) 19 (38%) 16 (32%)
Hydronephrosis 19 (38%) 20 (40%) 30 (60%) 15 (30%)
Inflammation, Acute 2 (4%) 1 (2%)
Mineralization 8 (16%) 17 (34%) 8 (16%) 5 (10%)
Nephropathy 50 (100%) 50 (100%) 50 (100%) 50 (100%)
Artery, Mineralization 5 (10%) 8 (16%) 3 (6%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia 6 (12%) 17 (34%) 8 (16%) 5 (10%)
Vein, Thrombosis 2 (4%) 1 (2%) 3 (6%)
Urinary Bladder (47) (49) (47) (44)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:18:24
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Dilatation 1 (2%)
Edema 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Ulcer 1 (2%)
Artery, Mineralization 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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