TDMS Study 55301-06 Pathology Tables
NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 11:55:09
Facility: TSI Mason Research
Chemical CAS #: 110-86-1
Lock Date: 12/13/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 11:55:09
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WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
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DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 26 27 30 33
Moribund Sacrifice 2 9 9 10
Survivors
Terminal Sacrifice 22 14 11 7
Animals Examined Microscopically 50 50 50 50
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ALIMENTARY SYSTEM
Intestine Large, Cecum (32) (37) (29) (27)
Carcinoma 1 (3%)
Intestine Small, Duodenum (39) (44) (42) (42)
Carcinoma 1 (2%)
Intestine Small, Jejunum (37) (36) (34) (35)
Carcinoma 1 (3%) 2 (6%)
Intestine Small, Ileum (28) (32) (28) (31)
Liver (50) (50) (50) (50)
Cholangiocarcinoma 1 (2%) 2 (4%)
Hepatocellular Adenoma 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Oral Mucosa (5) (1) (1)
Squamous Cell Carcinoma 1 (20%)
Pancreas (46) (50) (50) (49)
Carcinoma 1 (2%)
Acinus, Adenoma 6 (13%) 7 (14%) 8 (16%) 7 (14%)
Acinus, Adenoma, Multiple 8 (17%) 4 (8%) 4 (8%)
Acinus, Carcinoma 2 (4%) 2 (4%)
Acinus, Carcinoma, Multiple 2 (4%) 1 (2%)
Stomach, Forestomach (49) (50) (50) (49)
Fibrosarcoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (49) (50) (48) (48)
Fibrosarcoma, Metastatic, Stomach,
Forestomach 1 (2%)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
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NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 11:55:09
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Endocardium, Schwannoma Benign 2 (4%) 2 (4%) 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Pheochromocytoma Benign 5 (10%) 4 (8%) 1 (2%)
Islets, Pancreatic (47) (50) (49) (49)
Adenoma 8 (17%) 3 (6%)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (48) (47) (48) (47)
Adenoma 1 (2%)
Pituitary Gland (49) (49) (50) (50)
Pars Distalis, Adenoma 15 (31%) 16 (33%) 12 (24%) 13 (26%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (49) (50) (48) (49)
Bilateral, Follicular Cell, Adenoma 1 (2%)
C-Cell, Adenoma 4 (8%) 2 (4%) 3 (6%)
Follicular Cell, Adenoma 4 (8%)
Follicular Cell, Carcinoma 3 (6%) 3 (6%) 1 (2%)
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GENERAL BODY SYSTEM
Tissue NOS (1)
Hemangiosarcoma 1 (100%)
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GENITAL SYSTEM
Epididymis (50) (49) (49) (50)
Preputial Gland (50) (48) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Prostate (50) (49) (50) (50)
Adenoma 3 (6%) 1 (2%) 1 (2%)
Schwannoma Malignant 1 (2%)
Seminal Vesicle (49) (49) (50) (49)
Testes (50) (49) (49) (50)
Bilateral, Interstitial Cell, Adenoma 3 (6%) 1 (2%) 1 (2%) 5 (10%)
Interstitial Cell, Adenoma 2 (4%) 5 (10%) 3 (6%) 7 (14%)
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NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 11:55:09
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (31) (44) (38) (32)
Iliac, Hemangiosarcoma 1 (2%)
Pancreatic, Histiocytic Sarcoma 1 (3%)
Lymph Node, Mandibular (48) (49) (47) (48)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (46) (50) (50) (50)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (49) (50) (49) (49)
Hemangiosarcoma 1 (2%)
Thymus (48) (49) (49) (50)
Thymoma Benign 1 (2%) 2 (4%)
Thymoma Malignant 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (48) (46) (44) (46)
Carcinoma 1 (2%)
Fibroadenoma 1 (2%) 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Fibroma 2 (4%)
Keratoacanthoma 7 (14%) 3 (6%) 2 (4%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%) 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%) 6 (12%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cranium, Osteoma 1 (2%)
Joint, Sarcoma 1 (2%)
Skeletal Muscle (1) (2)
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NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 11:55:09
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont
Fibroma 1 (50%)
Lipoma 1 (100%) 1 (50%)
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NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Astrocytoma Malignant 1 (2%) 1 (2%) 1 (2%)
Hemangioma 1 (2%)
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RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%) 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma 1 (2%)
Nose (50) (50) (50) (50)
Chondroma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
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SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2) (3)
Carcinoma 1 (100%) 2 (100%) 3 (100%)
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URINARY SYSTEM
Kidney (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lipoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 4 (8%) 1 (2%) 2 (4%)
Renal Tubule, Adenoma, Multiple 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 11:55:09
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 1 (2%) 1 (2%) 2 (4%)
Lymphoma Malignant 2 (4%) 1 (2%)
Mesothelioma Malignant 1 (2%)
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NTP Experiment-Test: 55301-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 11:55:09
____________________________________________________________________________________________________________________________________
WISTAR OUTBRED RATS MALE 0 PPM 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 43 38 32 39
Total Primary Neoplasms 101 79 68 62
Total Animals with Benign Neoplasms 40 37 29 33
Total Benign Neoplasms 84 61 51 47
Total Animals with Malignant Neoplasms 17 14 12 13
Total Malignant Neoplasms 17 18 17 15
Total Animals with Metastatic Neoplasms 1 3 2
Total Metastatic Neoplasm 1 4 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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