Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/5362

TDMS Study 55301-06 Pathology Tables

NTP Experiment-Test: 55301-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              PYRIDINE                                         Date: 10/08/97
Route: DOSED WATER                                                                                                Time: 11:55:09




       Facility:  TSI Mason Research

       Chemical CAS #:  110-86-1

       Lock Date:  12/13/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 55301-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              PYRIDINE                                         Date: 10/08/97  
Route: DOSED WATER                                                                                                Time: 11:55:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         WISTAR OUTBRED RATS MALE                  0 PPM        100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     26           27           30           33                                     
    Moribund Sacrifice                                 2            9            9           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           14           11            7                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (32)         (37)         (29)         (27)                                   
      Carcinoma                                        1 (3%)                                                                       
   Intestine Small, Duodenum                          (39)         (44)         (42)         (42)                                   
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Jejunum                           (37)         (36)         (34)         (35)                                   
      Carcinoma                                        1 (3%)       2 (6%)                                                          
   Intestine Small, Ileum                             (28)         (32)         (28)         (31)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                               1 (2%)                                 2 (4%)                                
      Hepatocellular Adenoma                           2 (4%)                    1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Oral Mucosa                                        (5)          (1)          (1)                                                 
      Squamous Cell Carcinoma                          1 (20%)                                                                      
   Pancreas                                           (46)         (50)         (50)         (49)                                   
      Carcinoma                                                     1 (2%)                                                          
      Acinus, Adenoma                                  6 (13%)      7 (14%)      8 (16%)      7 (14%)                               
      Acinus, Adenoma, Multiple                        8 (17%)      4 (8%)       4 (8%)                                             
      Acinus, Carcinoma                                2 (4%)                    2 (4%)                                             
      Acinus, Carcinoma, Multiple                      2 (4%)                    1 (2%)                                             
   Stomach, Forestomach                               (49)         (50)         (50)         (49)                                   
      Fibrosarcoma                                                               1 (2%)                                             
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (49)         (50)         (48)         (48)                                   
      Fibrosarcoma, Metastatic, Stomach,                                                                                            
          Forestomach                                                            1 (2%)                                             
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 55301-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              PYRIDINE                                         Date: 10/08/97  
Route: DOSED WATER                                                                                                Time: 11:55:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         WISTAR OUTBRED RATS MALE                  0 PPM        100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Endocardium, Schwannoma Benign                   2 (4%)       2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                                               1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Pheochromocytoma Benign                          5 (10%)      4 (8%)       1 (2%)                                             
   Islets, Pancreatic                                 (47)         (50)         (49)         (49)                                   
      Adenoma                                          8 (17%)                   3 (6%)                                             
      Carcinoma                                                     1 (2%)                    1 (2%)                                
   Parathyroid Gland                                  (48)         (47)         (48)         (47)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (49)         (49)         (50)         (50)                                   
      Pars Distalis, Adenoma                          15 (31%)     16 (33%)     12 (24%)     13 (26%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)       1 (2%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)                                 1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (48)         (49)                                   
      Bilateral, Follicular Cell, Adenoma                                        1 (2%)                                             
      C-Cell, Adenoma                                  4 (8%)       2 (4%)                    3 (6%)                                
      Follicular Cell, Adenoma                                                   4 (8%)                                             
      Follicular Cell, Carcinoma                       3 (6%)       3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Hemangiosarcoma                                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (49)         (50)                                   
   Preputial Gland                                    (50)         (48)         (50)         (50)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
   Prostate                                           (50)         (49)         (50)         (50)                                   
      Adenoma                                          3 (6%)       1 (2%)       1 (2%)                                             
      Schwannoma Malignant                                                                    1 (2%)                                
   Seminal Vesicle                                    (49)         (49)         (50)         (49)                                   
   Testes                                             (50)         (49)         (49)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma            3 (6%)       1 (2%)       1 (2%)       5 (10%)                               
      Interstitial Cell, Adenoma                       2 (4%)       5 (10%)      3 (6%)       7 (14%)                               

                                                             Page   3                                                               
NTP Experiment-Test: 55301-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              PYRIDINE                                         Date: 10/08/97  
Route: DOSED WATER                                                                                                Time: 11:55:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         WISTAR OUTBRED RATS MALE                  0 PPM        100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (31)         (44)         (38)         (32)                                   
      Iliac, Hemangiosarcoma                                        1 (2%)                                                          
      Pancreatic, Histiocytic Sarcoma                                                         1 (3%)                                
   Lymph Node, Mandibular                             (48)         (49)         (47)         (48)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node, Mesenteric                             (46)         (50)         (50)         (50)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Spleen                                             (49)         (50)         (49)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Thymus                                             (48)         (49)         (49)         (50)                                   
      Thymoma Benign                                   1 (2%)                    2 (4%)                                             
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (46)         (44)         (46)                                   
      Carcinoma                                                                  1 (2%)                                             
      Fibroadenoma                                     1 (2%)       1 (2%)                    1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Fibroma                                                                    2 (4%)                                             
      Keratoacanthoma                                  7 (14%)      3 (6%)       2 (4%)       1 (2%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          2 (4%)       1 (2%)       1 (2%)                                             
      Sebaceous Gland, Adenoma                                                   1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     5 (10%)      6 (12%)                   1 (2%)                                
      Subcutaneous Tissue, Fibroma, Multiple                                                  1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cranium, Osteoma                                 1 (2%)                                                                       
      Joint, Sarcoma                                                                          1 (2%)                                
   Skeletal Muscle                                    (1)                       (2)                                                 

                                                             Page   4                                                               
NTP Experiment-Test: 55301-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              PYRIDINE                                         Date: 10/08/97  
Route: DOSED WATER                                                                                                Time: 11:55:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         WISTAR OUTBRED RATS MALE                  0 PPM        100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - cont                                                                                                       
      Fibroma                                                                    1 (50%)                                            
      Lipoma                                           1 (100%)                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)       1 (2%)       1 (2%)                                             
      Hemangioma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)       1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Chondroma                                                                               1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (2)          (3)                                    
      Carcinoma                                        1 (100%)                  2 (100%)     3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Lipoma                                           1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)       4 (8%)       1 (2%)       2 (4%)                                
      Renal Tubule, Adenoma, Multiple                  1 (2%)       1 (2%)                                                          
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 55301-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              PYRIDINE                                         Date: 10/08/97  
Route: DOSED WATER                                                                                                Time: 11:55:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         WISTAR OUTBRED RATS MALE                  0 PPM        100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                             1 (2%)       1 (2%)       2 (4%)                                             
      Lymphoma Malignant                                            2 (4%)                    1 (2%)                                
      Mesothelioma Malignant                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________

                                                             Page   6                                                               
NTP Experiment-Test: 55301-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              PYRIDINE                                         Date: 10/08/97  
Route: DOSED WATER                                                                                                Time: 11:55:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         WISTAR OUTBRED RATS MALE                  0 PPM        100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          38          32          39                                       
     Total Primary Neoplasms                          101          79          68          62                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          37          29          33                                       
     Total Benign Neoplasms                            84          61          51          47                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          14          12          13                                       
     Total Malignant Neoplasms                         17          18          17          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       3           2                                       
     Total Metastatic Neoplasm                          1                       4           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------