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TDMS Study 55301-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/29/97

EXPERIMENT: 55301 TEST: 06                                                                                     TIME: 09:12:05
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01-ES-95268                              ROUTE: DOSED WATER                                             NTP C#: 55301B
PATHOLOGIST: D. SAUER                                                                                          CAS: 110-86-1
                    

Rats(WISTAR OUTBRED)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/29/97     
EXPERIMENT: 55301 TEST: 06                                                                                     TIME: 09:12:05     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-95268                              ROUTE: DOSED WATER                                             NTP C#: 55301B     
PATHOLOGIST: D. SAUER                                                                                          CAS: 110-86-1      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                     PYRIDINE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hemorrhage
                                       Necrosis
                                       Vacuolization Cytoplasmic
Blood Vessel                           Mineralization
Blood Vessel: Aorta                    Mineralization
Bone                                   Fibrous Osteodystrophy
Bone: Cranium                          Fibrous Osteodystrophy
Bone: Vertebra                         Fibrous Osteodystrophy
Heart                                  Cardiomyopathy
                                       Mineralization
Heart: Artery                          Mineralization
Kidney                                 Congestion
                                       Cyst
                                       Hydronephrosis
                                       Mineralization
Kidney: Artery                         Mineralization
Kidney: Renal Tubule                   Hyperplasia
Kidney: Vein                           Thrombosis
Liver                                  Angiectasis
                                       Basophilic Focus
                                       Clear Cell Focus
                                       Congestion
                                       Degeneration Cystic
                                       Eosinophilic Focus
                                       Fibrosis
                                       Hemorrhage
                                       Mineralization
                                       Pigmentation
                                       Regeneration
Liver: Bile Duct                       Cyst
                                       Hyperplasia
Liver: Centrilobular                   Degeneration
                                       Necrosis
Liver: Periportal                      Fibrosis
Lung                                   Congestion
                                       Hemorrhage
Lung: Alveolus                         Infiltration Cellular Histiocyte
Lung: Artery                           Mineralization
Lymph Node, Mandibular                 Congestion
Lymph Node, Mediastinal                Ectasia
                                       Hemorrhage
Lymph Node, Mesenteric                 Atrophy
                                       Hyperplasia Lymphoid
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: TSI Mason Research                                         PYRIDINE                                       DATE: 09/29/97     
EXPERIMENT: 55301 TEST: 06                                                                                     TIME: 09:12:05     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-95268                              ROUTE: DOSED WATER                                             NTP C#: 55301B     
PATHOLOGIST: D. SAUER                                                                                          CAS: 110-86-1      

Lymph Node: Iliac                      Hemorrhage
                                       Hyperplasia
Lymph Node: Pancreatic                 Hemorrhage
Lymph Node: Renal                      Hemorrhage
                                       Hyperplasia
                                       Hyperplasia Lymphoid
Mammary Gland: Artery                  Mineralization
Mesentery: Artery                      Inflammation
Mesentery: Vein                        Thrombosis
Nose                                   Foreign Body
                                       Inflammation Acute
Nose: Respiratory Epithelium           Hyperplasia
Pancreas                               Hyperplasia
Parathyroid Gland                      Hyperplasia
Peripheral Nerve                       Radicular Neuropathy
Pituitary Gland                        Congestion
                                       Hyperplasia
Preputial Gland                        Inflammation
Preputial Gland: Duct                  Cyst
Prostate                               Inflammation Acute
Skin                                   Hyperplasia
Stomach, Forestomach                   Cyst
                                       Foreign Body
                                       Hyperplasia
                                       Inflammation Chronic
Stomach, Glandular                     Mineralization
Testes                                 Atrophy
Testes: Artery                         Inflammation
Testes: Interstitial Cell              Hyperplasia
Thymus                                 Atrophy
                                       Hemorrhage
                                       Hyperplasia
Thyroid Gland: Follicle                Cyst
===============================================================
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.6%                     0.0%                     3.5%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      642                      ---                      595             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.326                  P=0.181                  (e)                      P=0.372         |
|POLY 3             |                  P=0.414                  P=0.210                  (e)                      P=0.434         |
|POLY 1.5           |                  P=0.469                  P=0.221                  (e)                      P=0.462         |
|POLY 6             |                  P=0.346                  P=0.198                  (e)                      P=0.395         |
|LOGISTIC REGRESSION|                  P=0.477                  P=0.205                  (e)                      P=0.534         |
|COCH-ARM / FISHERS |                  P=0.539                  P=0.247                  (e)                      P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.6%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      642                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.553N                 P=0.193                  (e)                      (e)             |
|POLY 3             |                  P=0.489N                 P=0.211                  (e)                      (e)             |
|POLY 1.5           |                  P=0.452N                 P=0.221                  (e)                      (e)             |
|POLY 6             |                  P=0.552N                 P=0.201                  (e)                      (e)             |
|LOGISTIC REGRESSION|                  P=0.444N                 P=0.231                  (e)                      (e)             |
|COCH-ARM / FISHERS |                  P=0.405N                 P=0.247                  (e)                      (e)             |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/50 (6%)                0/50 (0%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  7.4%                     0.0%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  616                      ---                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.113N                 P=0.199N                 P=0.227N                 P=0.343N        |
|POLY 3             |                  P=0.039N*                P=0.145N                 P=0.154N                 P=0.197N        |
|POLY 1.5           |                  P=0.041N*                P=0.134N                 P=0.138N                 P=0.159N        |
|POLY 6             |                  P=0.039N*                P=0.161N                 P=0.176N                 P=0.263N        |
|LOGISTIC REGRESSION|                  P=0.075N                 P=0.149N                 P=0.161N                 P=0.237N        |
|COCH-ARM / FISHERS |                  P=0.047N*                P=0.121N                 P=0.121N                 P=0.121N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                1/50 (2%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     5.5%                     2.9%                     3.5%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  470                      588                      562             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.520                  P=0.424                  P=0.655                  P=0.571         |
|POLY 3             |                  P=0.572                  P=0.463                  P=0.725                  P=0.680         |
|POLY 1.5           |                  P=0.586N                 P=0.478                  P=0.740                  P=0.717         |
|POLY 6             |                  P=0.488                  P=0.447                  P=0.706                  P=0.625         |
|LOGISTIC REGRESSION|                  P=0.480N                 P=0.539                  P=0.751                  P=0.738         |
|COCH-ARM / FISHERS |                  P=0.531N                 P=0.500                  P=0.753N                 P=0.753N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)                2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.0%                     5.7%                     5.9%                     0.0%            |
|TERMINAL (d)       |                  1/22 (5%)                1/14 (7%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  705                      690                      632                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.463N                 P=0.544                  P=0.484                  P=0.511N        |
|POLY 3             |                  P=0.261N                 P=0.646                  P=0.634                  P=0.324N        |
|POLY 1.5           |                  P=0.214N                 P=0.666                  P=0.660                  P=0.283N        |
|POLY 6             |                  P=0.347N                 P=0.623                  P=0.602                  P=0.386N        |
|LOGISTIC REGRESSION|                  P=0.351N                 P=0.591                  P=0.589                  P=0.470N        |
|COCH-ARM / FISHERS |                  P=0.163N                 P=0.691N                 P=0.691N                 P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     0.0%                     7.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      ---                      658             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.010 *                (e)                      (e)                      P=0.074         |
|POLY 3             |                  P=0.036 *                (e)                      (e)                      P=0.170         |
|POLY 1.5           |                  P=0.039 *                (e)                      (e)                      P=0.197         |
|POLY 6             |                  P=0.034 *                (e)                      (e)                      P=0.139         |
|LOGISTIC REGRESSION|                  P=0.019 *                (e)                      (e)                      P=0.122         |
|COCH-ARM / FISHERS |                  P=0.046 *                (e)                      (e)                      P=0.247         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  17/50 (34%)              13/50 (26%)              12/50 (24%)              7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                  39.7%                    34.6%                    33.7%                    23.1%           |
|TERMINAL (d)       |                  9/22 (41%)               6/14 (43%)               4/11 (36%)               2/7 (29%)       |
|FIRST INCIDENCE    |                  572                      486                      404                      466             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.497                  P=0.502                  P=0.432                  P=0.588N        |
|POLY 3             |                  P=0.088N                 P=0.403N                 P=0.376N                 P=0.106N        |
|POLY 1.5           |                  P=0.040N*                P=0.337N                 P=0.283N                 P=0.049N*       |
|POLY 6             |                  P=0.225N                 P=0.492N                 P=0.509N                 P=0.259N        |
|LOGISTIC REGRESSION|                  P=0.107N                 P=0.377N                 P=0.372N                 P=0.108N        |
|COCH-ARM / FISHERS |                  P=0.014N*                P=0.257N                 P=0.189N                 P=0.017N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/50 (6%)                4/50 (8%)                2/50 (4%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  7.4%                     11.2%                    5.9%                     3.6%            |
|TERMINAL (d)       |                  2/22 (9%)                1/14 (7%)                1/11 (9%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  576                      660                      682                      722 (T)         |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.531N                 P=0.319                  P=0.631                  P=0.689N        |
|POLY 3             |                  P=0.286N                 P=0.428                  P=0.581N                 P=0.445N        |
|POLY 1.5           |                  P=0.226N                 P=0.457                  P=0.547N                 P=0.381N        |
|POLY 6             |                  P=0.393N                 P=0.397                  P=0.623N                 P=0.538N        |
|LOGISTIC REGRESSION|                  P=0.383N                 P=0.416                  P=0.607N                 P=0.548N        |
|COCH-ARM / FISHERS |                  P=0.162N                 P=0.500                  P=0.500N                 P=0.309N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel                                                                                                                     |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  6/8 (75%)                6/23 (26%)               1/12 (8%)                0/3 (0%)        |
|POLY-3 ADJUSTED (b)|                  80.7%                    35.2%                    13.8%                    0.0%            |
|TERMINAL (d)       |                  0/0 (0%)                 0/2 (0%)                 0/0 (0%)                 0/0 (0%)        |
|FIRST INCIDENCE    |                  468                      445                      500                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.023N*                P=0.490                  P=0.109N                 P=0.088N        |
|POLY 3             |                  P=0.002N**               P=0.027N*                P=0.004N**               P=0.255N        |
|POLY 1.5           |                  P=0.002N**               P=0.020N*                P<0.001N**               P=0.107N        |
|POLY 6             |                  P=0.006N**               P=0.048N*                P=0.019N*                P=0.556N        |
|LOGISTIC REGRESSION|                  P=0.003N**               P=0.021N*                P=0.004N**               P=0.059N        |
|COCH-ARM / FISHERS |                  P=0.005N**               P=0.022N*                P=0.004N**               P=0.061N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Aorta                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  7/8 (88%)                21/23 (91%)              10/12 (83%)              3/3 (100%)      |
|POLY-3 ADJUSTED (b)|                  96.3%                    94.4%                    88.5%                    100.0%          |
|TERMINAL (d)       |                  0/0 (0%)                 1/2 (50%)                0/0 (0%)                 0/0 (0%)        |
|FIRST INCIDENCE    |                  557                      352                      354                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.309N                 P=0.002 **               P=0.150                  P=0.518N        |
|POLY 3             |                  P=0.744N                 P=0.802N                 P=0.626N                 P=0.999         |
|POLY 1.5           |                  P=0.736N                 P=0.812                  P=0.616N                 P=0.919         |
|POLY 6             |                  P=0.794N                 P=0.750N                 P=0.751N                 P=1.000         |
|LOGISTIC REGRESSION|                  P=0.591                  P=0.636                  P=0.663N                 (e)             |
|COCH-ARM / FISHERS |                  P=0.613                  P=0.606                  P=0.656N                 P=0.727         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Pulmonary Artery                                                                                                   |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/8 (38%)                3/23 (13%)               5/12 (42%)               2/3 (67%)       |
|POLY-3 ADJUSTED (b)|                  52.1%                    20.1%                    60.2%                    86.8%           |
|TERMINAL (d)       |                  0/0 (0%)                 0/2 (0%)                 0/0 (0%)                 0/0 (0%)        |
|FIRST INCIDENCE    |                  559                      634                      501                      499             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.326                  P=0.532                  P=0.215                  P=0.586         |
|POLY 3             |                  P=0.109                  P=0.167N                 P=0.604                  P=0.449         |
|POLY 1.5           |                  P=0.112                  P=0.165N                 P=0.594                  P=0.432         |
|POLY 6             |                  P=0.123                  P=0.170N                 P=0.655                  P=0.531         |
|LOGISTIC REGRESSION|                  P=0.062                  P=0.125N                 P=0.554                  P=0.309         |
|COCH-ARM / FISHERS |                  P=0.131                  P=0.161N                 P=0.612                  P=0.424         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  10/50 (20%)              21/50 (42%)              16/50 (32%)              6/50 (12%)      |
|POLY-3 ADJUSTED (b)|                  23.4%                    48.4%                    38.7%                    18.9%           |
|TERMINAL (d)       |                  1/22 (5%)                1/14 (7%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      352                      354                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.527                  P=0.007 **               P=0.041 *                P=0.491         |
|POLY 3             |                  P=0.304N                 P=0.011 *                P=0.095                  P=0.429N        |
|POLY 1.5           |                  P=0.158N                 P=0.012 *                P=0.107                  P=0.323N        |
|POLY 6             |                  P=0.510                  P=0.012 *                P=0.085                  P=0.584N        |
|LOGISTIC REGRESSION|                  P=0.009N**               P=0.033 *                P=0.276                  P=0.118N        |
|COCH-ARM / FISHERS |                  P=0.055N                 P=0.015 *                P=0.127                  P=0.207N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow: Myeloid Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  4.9%                     2.9%                     2.9%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  624                      722 (T)                  494                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.278N                 P=0.598N                 P=0.566N                 P=0.413N        |
|POLY 3             |                  P=0.200N                 P=0.552N                 P=0.558N                 P=0.327N        |
|POLY 1.5           |                  P=0.178N                 P=0.530N                 P=0.533N                 P=0.285N        |
|POLY 6             |                  P=0.248N                 P=0.579N                 P=0.589N                 P=0.392N        |
|LOGISTIC REGRESSION|                  P=0.149N                 P=0.536N                 P=0.431N                 P=0.262N        |
|COCH-ARM / FISHERS |                  P=0.153N                 P=0.500N                 P=0.500N                 P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone: Cranium                                                                                                                    |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  10/50 (20%)              15/50 (30%)              13/50 (26%)              2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  23.4%                    36.2%                    32.8%                    6.8%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      352                      354                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.207N                 P=0.085                  P=0.119                  P=0.216N        |
|POLY 3             |                  P=0.101N                 P=0.143                  P=0.237                  P=0.065N        |
|POLY 1.5           |                  P=0.036N*                P=0.154                  P=0.270                  P=0.034N*       |
|POLY 6             |                  P=0.299N                 P=0.137                  P=0.204                  P=0.145N        |
|LOGISTIC REGRESSION|                  P=0.002N**               P=0.273                  P=0.478                  P=0.014N*       |
|COCH-ARM / FISHERS |                  P=0.008N**               P=0.178                  P=0.318                  P=0.014N*       |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone: Vertebra                                                                                                                   |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                4/50 (8%)                2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     10.9%                    5.8%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      506                      501                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.537N                 P=0.047 *                P=0.158                  (e)             |
|POLY 3             |                  P=0.535N                 P=0.049 *                P=0.204                  (e)             |
|POLY 1.5           |                  P=0.444N                 P=0.053                  P=0.218                  (e)             |
|POLY 6             |                  P=0.492                  P=0.045 *                P=0.189                  (e)             |
|LOGISTIC REGRESSION|                  P=0.283N                 P=0.082                  P=0.260                  (e)             |
|COCH-ARM / FISHERS |                  P=0.337N                 P=0.059                  P=0.247                  (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  49/50 (98%)              49/50 (98%)              49/50 (98%)              47/50 (94%)     |
|POLY-3 ADJUSTED (b)|                  98.0%                    99.8%                    99.4%                    98.9%           |
|TERMINAL (d)       |                  21/22 (96%)              14/14 (100%)             11/11 (100%)             7/7 (100%)      |
|FIRST INCIDENCE    |                  283                      352                      354                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               P=0.048 *                P=0.011 *                P<0.001 **      |
|POLY 3             |                  P=0.612                  P=0.544                  P=0.623                  P=0.706         |
|POLY 1.5           |                  P=0.565N                 P=0.622                  P=0.690                  P=0.758N        |
|POLY 6             |                  P=0.388                  P=0.508                  P=0.545                  P=0.571         |
|LOGISTIC REGRESSION|                  P=0.416N                 P=0.690                  P=0.737                  P=0.634N        |
|COCH-ARM / FISHERS |                  P=0.163N                 P=0.753N                 P=0.753N                 P=0.309N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  6/50 (12%)               17/50 (34%)              12/50 (24%)              3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                  14.3%                    40.8%                    30.7%                    10.1%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      445                      479                      550             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.470N                 P=0.005 **               P=0.040 *                P=0.636N        |
|POLY 3             |                  P=0.344N                 P=0.005 **               P=0.061                  P=0.439N        |
|POLY 1.5           |                  P=0.180N                 P=0.005 **               P=0.073                  P=0.348N        |
|POLY 6             |                  P=0.455                  P=0.005 **               P=0.051                  P=0.568N        |
|LOGISTIC REGRESSION|                  P=0.023N*                P=0.018 *                P=0.184                  P=0.181N        |
|COCH-ARM / FISHERS |                  P=0.064N                 P=0.008 **               P=0.096                  P=0.243N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Artery                                                                                                                    |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  4/50 (8%)                15/50 (30%)              9/50 (18%)               2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  9.7%                     36.5%                    24.1%                    6.8%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  559                      352                      479                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.444N                 P=0.003 **               P=0.047 *                P=0.656N        |
|POLY 3             |                  P=0.333N                 P=0.003 **               P=0.076                  P=0.502N        |
|POLY 1.5           |                  P=0.188N                 P=0.003 **               P=0.091                  P=0.428N        |
|POLY 6             |                  P=0.494                  P=0.003 **               P=0.062                  P=0.604N        |
|LOGISTIC REGRESSION|                  P=0.033N*                P=0.011 *                P=0.168                  P=0.257N        |
|COCH-ARM / FISHERS |                  P=0.080N                 P=0.005 **               P=0.117                  P=0.339N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  4/50 (8%)                2/50 (4%)                5/50 (10%)               3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                  9.8%                     5.6%                     14.2%                    10.3%           |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  616                      642                      486                      580             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.193                  P=0.493N                 P=0.282                  P=0.358         |
|POLY 3             |                  P=0.413                  P=0.403N                 P=0.406                  P=0.626         |
|POLY 1.5           |                  P=0.501                  P=0.375N                 P=0.445                  P=0.603N        |
|POLY 6             |                  P=0.300                  P=0.436N                 P=0.360                  P=0.517         |
|LOGISTIC REGRESSION|                  P=0.462                  P=0.392N                 P=0.450                  P=0.644         |
|COCH-ARM / FISHERS |                  P=0.537N                 P=0.339N                 P=0.500                  P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/32 (3%)                2/37 (5%)                1/29 (3%)                0/27 (0%)       |
|POLY-3 ADJUSTED (b)|                  3.5%                     7.2%                     5.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/10 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  701                      561                      575                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.453N                 P=0.391                  P=0.676                  P=0.734N        |
|POLY 3             |                  P=0.428N                 P=0.488                  P=0.676                  P=0.614N        |
|POLY 1.5           |                  P=0.373N                 P=0.513                  P=0.701                  P=0.583N        |
|POLY 6             |                  P=0.517N                 P=0.458                  P=0.652                  P=0.650N        |
|LOGISTIC REGRESSION|                  P=0.300N                 P=0.562                  P=0.782N                 P=0.685N        |
|COCH-ARM / FISHERS |                  P=0.297N                 P=0.555                  P=0.729                  P=0.542N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/32 (0%)                2/37 (5%)                2/29 (7%)                1/27 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     7.3%                     9.8%                     6.1%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/10 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      679                      473                      499             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.261                  P=0.176                  P=0.173                  P=0.453         |
|POLY 3             |                  P=0.210                  P=0.225                  P=0.166                  P=0.392         |
|POLY 1.5           |                  P=0.276                  P=0.242                  P=0.183                  P=0.420         |
|POLY 6             |                  P=0.144                  P=0.207                  P=0.151                  P=0.359         |
|LOGISTIC REGRESSION|                  P=0.422                  P=0.209                  P=0.292                  P=0.668         |
|COCH-ARM / FISHERS |                  P=0.389                  P=0.284                  P=0.222                  P=0.458         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/32 (0%)                2/37 (5%)                0/29 (0%)                2/27 (7%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     7.1%                     0.0%                     11.9%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/10 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      573                      ---                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.148                  P=0.202                  (e)                      P=0.165         |
|POLY 3             |                  P=0.112                  P=0.232                  (e)                      P=0.135         |
|POLY 1.5           |                  P=0.138                  P=0.246                  (e)                      P=0.157         |
|POLY 6             |                  P=0.087                  P=0.216                  (e)                      P=0.113         |
|LOGISTIC REGRESSION|                  P=0.324                  P=0.394                  (e)                      P=0.355         |
|COCH-ARM / FISHERS |                  P=0.187                  P=0.284                  (e)                      P=0.205         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/47 (2%)                1/50 (2%)                2/49 (4%)                1/49 (2%)       |
|POLY-3 ADJUSTED (b)|                  2.6%                     2.8%                     6.0%                     3.6%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  593                      704                      616             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.304                  P=0.695                  P=0.321                  P=0.547         |
|POLY 3             |                  P=0.452                  P=0.747                  P=0.454                  P=0.690         |
|POLY 1.5           |                  P=0.518                  P=0.758                  P=0.480                  P=0.727         |
|POLY 6             |                  P=0.363                  P=0.733                  P=0.424                  P=0.633         |
|LOGISTIC REGRESSION|                  P=0.471                  P=0.765N                 P=0.376                  P=0.684         |
|COCH-ARM / FISHERS |                  P=0.600                  P=0.737N                 P=0.516                  P=0.742N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  4/50 (8%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  9.6%                     0.0%                     0.0%                     6.9%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  283                      ---                      ---                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.519N                 P=0.099N                 P=0.112N                 P=0.604N        |
|POLY 3             |                  P=0.326N                 P=0.085N                 P=0.091N                 P=0.513N        |
|POLY 1.5           |                  P=0.328N                 P=0.074N                 P=0.077N                 P=0.436N        |
|POLY 6             |                  P=0.326N                 P=0.099N                 P=0.112N                 P=0.618N        |
|LOGISTIC REGRESSION|                  P=0.220N                 P=0.030N*                P=0.028N*                P=0.177N        |
|COCH-ARM / FISHERS |                  P=0.337N                 P=0.059N                 P=0.059N                 P=0.339N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  21/50 (42%)              31/50 (62%)              19/50 (38%)              16/50 (32%)     |
|POLY-3 ADJUSTED (b)|                  48.8%                    71.0%                    48.2%                    47.6%           |
|TERMINAL (d)       |                  11/22 (50%)              7/14 (50%)               6/11 (55%)               4/7 (57%)       |
|FIRST INCIDENCE    |                  557                      445                      354                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.105                  P=0.005 **               P=0.134                  P=0.042 *       |
|POLY 3             |                  P=0.255N                 P=0.022 *                P=0.570N                 P=0.550N        |
|POLY 1.5           |                  P=0.121N                 P=0.023 *                P=0.503N                 P=0.383N        |
|POLY 6             |                  P=0.519N                 P=0.030 *                P=0.543                  P=0.421         |
|LOGISTIC REGRESSION|                  P=0.141N                 P=0.017 *                P=0.548N                 P=0.581         |
|COCH-ARM / FISHERS |                  P=0.039N*                P=0.036 *                P=0.419N                 P=0.204N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  19/50 (38%)              20/50 (40%)              30/50 (60%)              15/50 (30%)     |
|POLY-3 ADJUSTED (b)|                  43.9%                    51.3%                    66.4%                    43.5%           |
|TERMINAL (d)       |                  9/22 (41%)               7/14 (50%)               3/11 (27%)               2/7 (29%)       |
|FIRST INCIDENCE    |                  536                      336                      354                      450             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.025 *                P=0.134                  P=0.002 **               P=0.071         |
|POLY 3             |                  P=0.387                  P=0.320                  P=0.022 *                P=0.582N        |
|POLY 1.5           |                  P=0.511N                 P=0.396                  P=0.021 *                P=0.437N        |
|POLY 6             |                  P=0.194                  P=0.237                  P=0.026 *                P=0.421         |
|LOGISTIC REGRESSION|                  P=0.366N                 P=0.356                  P=0.037 *                P=0.426N        |
|COCH-ARM / FISHERS |                  P=0.281N                 P=0.500                  P=0.022 *                P=0.263N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.6%                     0.0%                     3.5%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      611                      ---                      660             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.327                  P=0.177                  (e)                      P=0.342         |
|POLY 3             |                  P=0.412                  P=0.210                  (e)                      P=0.432         |
|POLY 1.5           |                  P=0.468                  P=0.221                  (e)                      P=0.462         |
|POLY 6             |                  P=0.345                  P=0.199                  (e)                      P=0.393         |
|LOGISTIC REGRESSION|                  P=0.448                  P=0.217                  (e)                      P=0.423         |
|COCH-ARM / FISHERS |                  P=0.539                  P=0.247                  (e)                      P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  8/50 (16%)               17/50 (34%)              8/50 (16%)               5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                  18.8%                    40.7%                    21.4%                    16.5%           |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  557                      352                      404                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.482N                 P=0.015 *                P=0.372                  P=0.455         |
|POLY 3             |                  P=0.278N                 P=0.021 *                P=0.495                  P=0.524N        |
|POLY 1.5           |                  P=0.155N                 P=0.024 *                P=0.544                  P=0.410N        |
|POLY 6             |                  P=0.503N                 P=0.019 *                P=0.435                  P=0.560         |
|LOGISTIC REGRESSION|                  P=0.023N*                P=0.063                  P=0.457N                 P=0.230N        |
|COCH-ARM / FISHERS |                  P=0.064N                 P=0.032 *                P=0.607N                 P=0.277N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  50/50 (100%)             50/50 (100%)             50/50 (100%)             50/50 (100%)    |
|POLY-3 ADJUSTED (b)|                  100.0%                   100.0%                   100.0%                   100.0%          |
|TERMINAL (d)       |                  22/22 (100%)             14/14 (100%)             11/11 (100%)             7/7 (100%)      |
|FIRST INCIDENCE    |                  283                      336                      354                      94              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  (e)                      (e)                      (e)                      (e)             |
|POLY 3             |                  (e)                      (e)                      (e)                      (e)             |
|POLY 1.5           |                  (e)                      (e)                      (e)                      (e)             |
|POLY 6             |                  (e)                      (e)                      (e)                      (e)             |
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      (e)             |
|COCH-ARM / FISHERS |                  (e)                      (e)                      (e)                      (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Artery                                                                                                                   |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  5/50 (10%)               8/50 (16%)               3/50 (6%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  11.9%                    20.9%                    8.6%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      479                      500                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.079N                 P=0.169                  P=0.522N                 P=0.134N        |
|POLY 3             |                  P=0.051N                 P=0.211                  P=0.462N                 P=0.083N        |
|POLY 1.5           |                  P=0.025N*                P=0.236                  P=0.416N                 P=0.054N        |
|POLY 6             |                  P=0.125N                 P=0.187                  P=0.518N                 P=0.143N        |
|LOGISTIC REGRESSION|                  P=0.005N**               P=0.376                  P=0.264N                 P=0.016N*       |
|COCH-ARM / FISHERS |                  P=0.011N*                P=0.277                  P=0.357N                 P=0.028N*       |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  6/50 (12%)               17/50 (34%)              8/50 (16%)               5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                  14.5%                    41.6%                    22.0%                    16.2%           |
|TERMINAL (d)       |                  4/22 (18%)               3/14 (21%)               3/11 (27%)               0/7 (0%)        |
|FIRST INCIDENCE    |                  468                      445                      354                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.430                  P=0.003 **               P=0.122                  P=0.315         |
|POLY 3             |                  P=0.390N                 P=0.004 **               P=0.288                  P=0.552         |
|POLY 1.5           |                  P=0.255N                 P=0.005 **               P=0.330                  P=0.617N        |
|POLY 6             |                  P=0.489                  P=0.005 **               P=0.239                  P=0.438         |
|LOGISTIC REGRESSION|                  P=0.093N                 P=0.012 *                P=0.430                  P=0.434N        |
|COCH-ARM / FISHERS |                  P=0.131N                 P=0.008 **               P=0.387                  P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Vein                                                                                                                     |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                1/50 (2%)                3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.7%                     2.9%                     10.3%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      668                      561                      616             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.021 *                P=0.173                  P=0.450                  P=0.033 *       |
|POLY 3             |                  P=0.055                  P=0.210                  P=0.469                  P=0.071         |
|POLY 1.5           |                  P=0.073                  P=0.221                  P=0.482                  P=0.089         |
|POLY 6             |                  P=0.038 *                P=0.198                  P=0.453                  P=0.053         |
|LOGISTIC REGRESSION|                  P=0.073                  P=0.200                  P=0.557                  P=0.082         |
|COCH-ARM / FISHERS |                  P=0.104                  P=0.247                  P=0.500                  P=0.121         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  5/50 (10%)               9/50 (18%)               2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  12.4%                    24.2%                    5.7%                     0.0%            |
|TERMINAL (d)       |                  3/22 (14%)               1/14 (7%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  695                      561                      354                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.089N                 P=0.080                  P=0.434N                 P=0.230N        |
|POLY 3             |                  P=0.025N*                P=0.144                  P=0.276N                 P=0.074N        |
|POLY 1.5           |                  P=0.013N*                P=0.161                  P=0.249N                 P=0.051N        |
|POLY 6             |                  P=0.060N                 P=0.133                  P=0.312N                 P=0.123N        |
|LOGISTIC REGRESSION|                  P=0.014N*                P=0.123                  P=0.237N                 P=0.171N        |
|COCH-ARM / FISHERS |                  P=0.007N**               P=0.194                  P=0.218N                 P=0.028N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     0.0%                     6.9%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      ---                      550             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.019 *                (e)                      (e)                      P=0.119         |
|POLY 3             |                  P=0.036 *                (e)                      (e)                      P=0.172         |
|POLY 1.5           |                  P=0.039 *                (e)                      (e)                      P=0.198         |
|POLY 6             |                  P=0.033 *                (e)                      (e)                      P=0.142         |
|LOGISTIC REGRESSION|                  P=0.043 *                (e)                      (e)                      P=0.231         |
|COCH-ARM / FISHERS |                  P=0.046 *                (e)                      (e)                      P=0.247         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  15/50 (30%)              7/50 (14%)               8/50 (16%)               8/50 (16%)      |
|POLY-3 ADJUSTED (b)|                  36.5%                    19.6%                    23.7%                    28.1%           |
|TERMINAL (d)       |                  12/22 (55%)              6/14 (43%)               8/11 (73%)               7/7 (100%)      |
|FIRST INCIDENCE    |                  592                      470                      722 (T)                  631             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.088                  P=0.228N                 P=0.613                  P=0.129         |
|POLY 3             |                  P=0.260N                 P=0.077N                 P=0.167N                 P=0.318N        |
|POLY 1.5           |                  P=0.173N                 P=0.061N                 P=0.119N                 P=0.178N        |
|POLY 6             |                  P=0.432N                 P=0.104N                 P=0.254N                 P=0.590N        |
|LOGISTIC REGRESSION|                  P=0.305                  P=0.118N                 P=0.306N                 P=0.343         |
|COCH-ARM / FISHERS |                  P=0.100N                 P=0.045N*                P=0.077N                 P=0.077N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  19/50 (38%)              12/50 (24%)              6/50 (12%)               17/50 (34%)     |
|POLY-3 ADJUSTED (b)|                  42.4%                    31.3%                    17.1%                    46.6%           |
|TERMINAL (d)       |                  2/22 (9%)                2/14 (14%)               1/11 (9%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  536                      470                      631                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.055                  P=0.371N                 P=0.066N                 P=0.063         |
|POLY 3             |                  P=0.449                  P=0.204N                 P=0.013N*                P=0.437         |
|POLY 1.5           |                  P=0.542N                 P=0.151N                 P=0.006N**               P=0.573         |
|POLY 6             |                  P=0.303                  P=0.290N                 P=0.033N*                P=0.260         |
|LOGISTIC REGRESSION|                  P=0.462N                 P=0.105N                 P=0.004N**               P=0.310N        |
|COCH-ARM / FISHERS |                  P=0.436N                 P=0.097N                 P=0.002N**               P=0.418N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  7/50 (14%)               13/50 (26%)              9/50 (18%)               5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                  17.2%                    34.0%                    25.2%                    17.5%           |
|TERMINAL (d)       |                  5/22 (23%)               2/14 (14%)               2/11 (18%)               3/7 (43%)       |
|FIRST INCIDENCE    |                  618                      541                      515                      631             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.212                  P=0.032 *                P=0.103                  P=0.162         |
|POLY 3             |                  P=0.500N                 P=0.067                  P=0.279                  P=0.609         |
|POLY 1.5           |                  P=0.333N                 P=0.079                  P=0.325                  P=0.524N        |
|POLY 6             |                  P=0.339                  P=0.060                  P=0.232                  P=0.443         |
|LOGISTIC REGRESSION|                  P=0.510N                 P=0.063                  P=0.246                  P=0.310         |
|COCH-ARM / FISHERS |                  P=0.170N                 P=0.105                  P=0.393                  P=0.380N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  14/50 (28%)              12/50 (24%)              4/50 (8%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  34.3%                    33.0%                    11.7%                    7.0%            |
|TERMINAL (d)       |                  11/22 (50%)              7/14 (50%)               2/11 (18%)               0/7 (0%)        |
|FIRST INCIDENCE    |                  644                      634                      631                      658             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.051N                 P=0.320                  P=0.130N                 P=0.138N        |
|POLY 3             |                  P<0.001N**               P=0.550N                 P=0.019N*                P=0.008N**      |
|POLY 1.5           |                  P<0.001N**               P=0.493N                 P=0.013N*                P=0.003N**      |
|POLY 6             |                  P=0.004N**               P=0.592                  P=0.029N*                P=0.029N*       |
|LOGISTIC REGRESSION|                  P=0.011N*                P=0.495                  P=0.044N*                P=0.063N        |
|COCH-ARM / FISHERS |                  P<0.001N**               P=0.410N                 P=0.009N**               P<0.001N**      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                5/50 (10%)               26/50 (52%)              31/50 (62%)     |
|POLY-3 ADJUSTED (b)|                  2.5%                     13.8%                    61.3%                    76.7%           |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                4/11 (36%)               5/7 (71%)       |
|FIRST INCIDENCE    |                  707                      581                      354                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               P=0.054                  P<0.001 **               P<0.001 **      |
|POLY 3             |                  P<0.001 **               P=0.077                  P<0.001 **               P<0.001 **      |
|POLY 1.5           |                  P<0.001 **               P=0.086                  P<0.001 **               P<0.001 **      |
|POLY 6             |                  P<0.001 **               P=0.068                  P<0.001 **               P<0.001 **      |
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.077                  P<0.001 **               P<0.001 **      |
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.102                  P<0.001 **               P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)                5/50 (10%)               3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     2.8%                     14.2%                    10.1%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  616                      638                      447                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.042 *                P=0.720                  P=0.051                  P=0.160         |
|POLY 3             |                  P=0.069                  P=0.730                  P=0.071                  P=0.205         |
|POLY 1.5           |                  P=0.103                  P=0.743                  P=0.083                  P=0.246         |
|POLY 6             |                  P=0.037 *                P=0.715                  P=0.058                  P=0.158         |
|LOGISTIC REGRESSION|                  P=0.197                  P=0.753N                 P=0.116                  P=0.427         |
|COCH-ARM / FISHERS |                  P=0.162                  P=0.753N                 P=0.102                  P=0.309         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.0%                     2.8%                     5.8%                     0.0%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  701                      372                      487                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.353N                 P=0.602N                 P=0.549                  P=0.515N        |
|POLY 3             |                  P=0.287N                 P=0.539N                 P=0.641                  P=0.324N        |
|POLY 1.5           |                  P=0.246N                 P=0.522N                 P=0.663                  P=0.283N        |
|POLY 6             |                  P=0.361N                 P=0.560N                 P=0.613                  P=0.386N        |
|LOGISTIC REGRESSION|                  P=0.148N                 P=0.444N                 P=0.693                  P=0.462N        |
|COCH-ARM / FISHERS |                  P=0.200N                 P=0.500N                 P=0.691N                 P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                1/50 (2%)                2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     2.8%                     5.8%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      595                      561                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.551                  P=0.468                  P=0.193                  (e)             |
|POLY 3             |                  P=0.496                  P=0.476                  P=0.205                  (e)             |
|POLY 1.5           |                  P=0.587                  P=0.485                  P=0.218                  (e)             |
|POLY 6             |                  P=0.372                  P=0.465                  P=0.191                  (e)             |
|LOGISTIC REGRESSION|                  P=0.577N                 P=0.534                  P=0.274                  (e)             |
|COCH-ARM / FISHERS |                  P=0.616N                 P=0.500                  P=0.247                  (e)             |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)                3/50 (6%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     2.9%                     8.6%                     3.6%            |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  639                      722 (T)                  404                      709             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.287                  P=0.688                  P=0.221                  P=0.537         |
|POLY 3             |                  P=0.368                  P=0.729                  P=0.254                  P=0.674         |
|POLY 1.5           |                  P=0.452                  P=0.742                  P=0.276                  P=0.714         |
|POLY 6             |                  P=0.265                  P=0.711                  P=0.229                  P=0.612         |
|LOGISTIC REGRESSION|                  P=0.513                  P=0.731                  P=0.368                  P=0.657         |
|COCH-ARM / FISHERS |                  P=0.556                  P=0.753N                 P=0.309                  P=0.753N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                1/50 (2%)                3/50 (6%)                3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     2.8%                     8.5%                     10.0%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      581                      473                      483             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.027 *                P=0.465                  P=0.100                  P=0.087         |
|POLY 3             |                  P=0.030 *                P=0.476                  P=0.096                  P=0.075         |
|POLY 1.5           |                  P=0.043 *                P=0.486                  P=0.105                  P=0.092         |
|POLY 6             |                  P=0.018 *                P=0.465                  P=0.086                  P=0.056         |
|LOGISTIC REGRESSION|                  P=0.135                  P=0.542                  P=0.158                  P=0.225         |
|COCH-ARM / FISHERS |                  P=0.067                  P=0.500                  P=0.121                  P=0.121         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  6/50 (12%)               7/50 (14%)               6/50 (12%)               2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  14.6%                    19.0%                    16.0%                    6.9%            |
|TERMINAL (d)       |                  2/22 (9%)                3/14 (21%)               0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  598                      470                      447                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.387N                 P=0.291                  P=0.418                  P=0.504N        |
|POLY 3             |                  P=0.226N                 P=0.413                  P=0.554                  P=0.271N        |
|POLY 1.5           |                  P=0.153N                 P=0.448                  P=0.582                  P=0.203N        |
|POLY 6             |                  P=0.361N                 P=0.372                  P=0.518                  P=0.386N        |
|LOGISTIC REGRESSION|                  P=0.060N                 P=0.454                  P=0.486N                 P=0.188N        |
|COCH-ARM / FISHERS |                  P=0.086N                 P=0.500                  P=0.620N                 P=0.134N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  6/50 (12%)               15/50 (30%)              34/50 (68%)              42/50 (84%)     |
|POLY-3 ADJUSTED (b)|                  14.6%                    38.0%                    75.3%                    92.5%           |
|TERMINAL (d)       |                  2/22 (9%)                3/14 (21%)               6/11 (55%)               7/7 (100%)      |
|FIRST INCIDENCE    |                  557                      372                      354                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               P=0.008 **               P<0.001 **               P<0.001 **      |
|POLY 3             |                  P<0.001 **               P=0.013 *                P<0.001 **               P<0.001 **      |
|POLY 1.5           |                  P<0.001 **               P=0.016 *                P<0.001 **               P<0.001 **      |
|POLY 6             |                  P<0.001 **               P=0.011 *                P<0.001 **               P<0.001 **      |
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.023 *                P<0.001 **               P<0.001 **      |
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.024 *                P<0.001 **               P<0.001 **      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Regeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     0.0%                     6.9%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      ---                      556             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.013 *                (e)                      (e)                      P=0.088         |
|POLY 3             |                  P=0.036 *                (e)                      (e)                      P=0.172         |
|POLY 1.5           |                  P=0.039 *                (e)                      (e)                      P=0.198         |
|POLY 6             |                  P=0.033 *                (e)                      (e)                      P=0.141         |
|LOGISTIC REGRESSION|                  P=0.039 *                (e)                      (e)                      P=0.214         |
|COCH-ARM / FISHERS |                  P=0.046 *                (e)                      (e)                      P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  18/50 (36%)              18/50 (36%)              12/50 (24%)              15/50 (30%)     |
|POLY-3 ADJUSTED (b)|                  42.0%                    46.1%                    32.5%                    43.2%           |
|TERMINAL (d)       |                  8/22 (36%)               6/14 (43%)               3/11 (27%)               1/7 (14%)       |
|FIRST INCIDENCE    |                  468                      470                      473                      466             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.065                  P=0.200                  P=0.559                  P=0.059         |
|POLY 3             |                  P=0.472N                 P=0.439                  P=0.258N                 P=0.550         |
|POLY 1.5           |                  P=0.357N                 P=0.495                  P=0.200N                 P=0.508N        |
|POLY 6             |                  P=0.454                  P=0.380                  P=0.337N                 P=0.393         |
|LOGISTIC REGRESSION|                  P=0.431N                 P=0.447                  P=0.233N                 P=0.498N        |
|COCH-ARM / FISHERS |                  P=0.228N                 P=0.582N                 P=0.138N                 P=0.335N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                2/50 (4%)                3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     5.9%                     10.3%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      645                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.004 **               (e)                      P=0.147                  P=0.043 *       |
|POLY 3             |                  P=0.013 *                (e)                      P=0.202                  P=0.072         |
|POLY 1.5           |                  P=0.018 *                (e)                      P=0.216                  P=0.090         |
|POLY 6             |                  P=0.009 **               (e)                      P=0.186                  P=0.053         |
|LOGISTIC REGRESSION|                  P=0.017 *                (e)                      P=0.186                  P=0.118         |
|COCH-ARM / FISHERS |                  P=0.028 *                (e)                      P=0.247                  P=0.121         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.7%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      679                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.594N                 P=0.176                  (e)                      (e)             |
|POLY 3             |                  P=0.490N                 P=0.209                  (e)                      (e)             |
|POLY 1.5           |                  P=0.453N                 P=0.220                  (e)                      (e)             |
|POLY 6             |                  P=0.553N                 P=0.198                  (e)                      (e)             |
|LOGISTIC REGRESSION|                  P=0.531N                 P=0.196                  (e)                      (e)             |
|COCH-ARM / FISHERS |                  P=0.405N                 P=0.247                  (e)                      (e)             |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  31/50 (62%)              33/50 (66%)              30/50 (60%)              27/50 (54%)     |
|POLY-3 ADJUSTED (b)|                  71.7%                    76.0%                    72.4%                    73.1%           |
|TERMINAL (d)       |                  21/22 (96%)              11/14 (79%)              9/11 (82%)               7/7 (100%)      |
|FIRST INCIDENCE    |                  536                      372                      354                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               P=0.026 *                P=0.015 *                P<0.001 **      |
|POLY 3             |                  P=0.542                  P=0.407                  P=0.573                  P=0.550         |
|POLY 1.5           |                  P=0.365N                 P=0.394                  P=0.576N                 P=0.489N        |
|POLY 6             |                  P=0.305                  P=0.490                  P=0.557                  P=0.338         |
|LOGISTIC REGRESSION|                  P=0.381                  P=0.180                  P=0.317                  P=0.118         |
|COCH-ARM / FISHERS |                  P=0.170N                 P=0.418                  P=0.500N                 P=0.272N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                15/50 (30%)              25/50 (50%)              33/50 (66%)     |
|POLY-3 ADJUSTED (b)|                  2.5%                     36.3%                    58.9%                    77.4%           |
|TERMINAL (d)       |                  1/22 (5%)                1/14 (7%)                6/11 (55%)               6/7 (86%)       |
|FIRST INCIDENCE    |                  722 (T)                  445                      481                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      |
|POLY 3             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      |
|POLY 1.5           |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      |
|POLY 6             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      |
|LOGISTIC REGRESSION|                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      |
|COCH-ARM / FISHERS |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  5/50 (10%)               6/50 (12%)               4/50 (8%)                23/50 (46%)     |
|POLY-3 ADJUSTED (b)|                  12.1%                    15.9%                    11.2%                    58.5%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  572                      486                      481                      450             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               P=0.349                  P=0.592                  P<0.001 **      |
|POLY 3             |                  P<0.001 **               P=0.437                  P=0.594N                 P<0.001 **      |
|POLY 1.5           |                  P<0.001 **               P=0.461                  P=0.554N                 P<0.001 **      |
|POLY 6             |                  P<0.001 **               P=0.412                  P=0.637                  P<0.001 **      |
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.580                  P=0.434N                 P<0.001 **      |
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.500                  P=0.500N                 P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                1/50 (2%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  5.0%                     0.0%                     3.0%                     3.5%            |
|TERMINAL (d)       |                  2/22 (9%)                0/14 (0%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  ---                      722 (T)                  627             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.498                  P=0.341N                 P=0.736                  P=0.664         |
|POLY 3             |                  P=0.531N                 P=0.267N                 P=0.560N                 P=0.616N        |
|POLY 1.5           |                  P=0.518N                 P=0.255N                 P=0.534N                 P=0.566N        |
|POLY 6             |                  P=0.552N                 P=0.283N                 P=0.591N                 P=0.681N        |
|LOGISTIC REGRESSION|                  P=0.574                  (e)                      P=0.736                  P=0.740N        |
|COCH-ARM / FISHERS |                  P=0.500N                 P=0.247N                 P=0.500N                 P=0.500N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Periportal                                                                                                                |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                5/50 (10%)               7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     14.1%                    22.6%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      473                      531             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               (e)                      P=0.021 *                P<0.001 **      |
|POLY 3             |                  P<0.001 **               (e)                      P=0.021 *                P=0.002 **      |
|POLY 1.5           |                  P<0.001 **               (e)                      P=0.024 *                P=0.004 **      |
|POLY 6             |                  P<0.001 **               (e)                      P=0.017 *                P<0.001 **      |
|LOGISTIC REGRESSION|                  P<0.001 **               (e)                      P=0.040 *                P=0.009 **      |
|COCH-ARM / FISHERS |                  P<0.001 **               (e)                      P=0.028 *                P=0.006 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                4/50 (8%)                2/50 (4%)                4/50 (8%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     11.0%                    5.7%                     13.5%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      549                      404                      553             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.025 *                P=0.044 *                P=0.211                  P=0.010 *       |
|POLY 3             |                  P=0.047 *                P=0.048 *                P=0.208                  P=0.030 *       |
|POLY 1.5           |                  P=0.070                  P=0.053                  P=0.220                  P=0.041 *       |
|POLY 6             |                  P=0.027 *                P=0.044 *                P=0.194                  P=0.020 *       |
|LOGISTIC REGRESSION|                  P=0.163                  P=0.071                  P=0.315                  P=0.053         |
|COCH-ARM / FISHERS |                  P=0.114                  P=0.059                  P=0.247                  P=0.059         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Edema                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.6%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      611                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.551N                 P=0.201                  (e)                      (e)             |
|POLY 3             |                  P=0.489N                 P=0.212                  (e)                      (e)             |
|POLY 1.5           |                  P=0.452N                 P=0.222                  (e)                      (e)             |
|POLY 6             |                  P=0.552N                 P=0.202                  (e)                      (e)             |
|LOGISTIC REGRESSION|                  P=0.408N                 P=0.248                  (e)                      (e)             |
|COCH-ARM / FISHERS |                  P=0.405N                 P=0.247                  (e)                      (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                10/50 (20%)              7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                  4.9%                     2.8%                     26.4%                    22.1%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  618                      647                      473                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               P=0.557N                 P=0.007 **               P=0.014 *       |
|POLY 3             |                  P=0.003 **               P=0.550N                 P=0.008 **               P=0.031 *       |
|POLY 1.5           |                  P=0.007 **               P=0.529N                 P=0.010 *                P=0.047 *       |
|POLY 6             |                  P<0.001 **               P=0.575N                 P=0.006 **               P=0.017 *       |
|LOGISTIC REGRESSION|                  P=0.039 *                P=0.482N                 P=0.029 *                P=0.141         |
|COCH-ARM / FISHERS |                  P=0.019 *                P=0.500N                 P=0.014 *                P=0.080         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     8.2%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  598                      549                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.255N                 P=0.250                  P=0.545N                 P=0.638N        |
|POLY 3             |                  P=0.224N                 P=0.267                  P=0.536N                 P=0.571N        |
|POLY 1.5           |                  P=0.189N                 P=0.282                  P=0.521N                 P=0.540N        |
|POLY 6             |                  P=0.288N                 P=0.252                  P=0.556N                 P=0.613N        |
|LOGISTIC REGRESSION|                  P=0.112N                 P=0.371                  P=0.465N                 P=0.470N        |
|COCH-ARM / FISHERS |                  P=0.153N                 P=0.309                  P=0.500N                 P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  4/50 (8%)                1/50 (2%)                5/50 (10%)               2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  10.0%                    2.9%                     14.5%                    7.0%            |
|TERMINAL (d)       |                  3/22 (14%)               1/14 (7%)                3/11 (27%)               1/7 (14%)       |
|FIRST INCIDENCE    |                  701                      722 (T)                  501                      631             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.240                  P=0.334N                 P=0.174                  P=0.506         |
|POLY 3             |                  P=0.550                  P=0.221N                 P=0.404                  P=0.504N        |
|POLY 1.5           |                  P=0.510N                 P=0.203N                 P=0.445                  P=0.429N        |
|POLY 6             |                  P=0.429                  P=0.244N                 P=0.355                  P=0.609N        |
|LOGISTIC REGRESSION|                  P=0.397                  P=0.291N                 P=0.328                  P=0.619         |
|COCH-ARM / FISHERS |                  P=0.420N                 P=0.181N                 P=0.500                  P=0.339N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)                2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     0.0%                     5.9%                     0.0%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  ---                      700                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.604                  P=0.590N                 P=0.296                  P=0.727N        |
|POLY 3             |                  P=0.553N                 P=0.527N                 P=0.441                  P=0.569N        |
|POLY 1.5           |                  P=0.511N                 P=0.516N                 P=0.466                  P=0.539N        |
|POLY 6             |                  P=0.608                  P=0.540N                 P=0.411                  P=0.610N        |
|LOGISTIC REGRESSION|                  P=0.641                  (e)                      P=0.348                  (e)             |
|COCH-ARM / FISHERS |                  P=0.461N                 P=0.500N                 P=0.500                  P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  8/50 (16%)               5/50 (10%)               4/50 (8%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  19.0%                    13.8%                    11.5%                    0.0%            |
|TERMINAL (d)       |                  2/22 (9%)                1/14 (7%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      549                      486                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.059N                 P=0.496N                 P=0.433N                 P=0.069N        |
|POLY 3             |                  P=0.014N*                P=0.376N                 P=0.279N                 P=0.020N*       |
|POLY 1.5           |                  P=0.007N**               P=0.333N                 P=0.231N                 P=0.010N*       |
|POLY 6             |                  P=0.038N*                P=0.430N                 P=0.345N                 P=0.051N        |
|LOGISTIC REGRESSION|                  P=0.006N**               P=0.292N                 P=0.192N                 P=0.008N**      |
|COCH-ARM / FISHERS |                  P=0.003N**               P=0.277N                 P=0.178N                 P=0.003N**      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  4.9%                     0.0%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      ---                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.164N                 P=0.285N                 P=0.304N                 P=0.365N        |
|POLY 3             |                  P=0.098N                 P=0.274N                 P=0.283N                 P=0.330N        |
|POLY 1.5           |                  P=0.104N                 P=0.258N                 P=0.263N                 P=0.287N        |
|POLY 6             |                  P=0.099N                 P=0.295N                 P=0.311N                 P=0.396N        |
|LOGISTIC REGRESSION|                  P=0.075N                 P=0.175N                 P=0.170N                 P=0.147N        |
|COCH-ARM / FISHERS |                  P=0.115N                 P=0.247N                 P=0.247N                 P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Artery                                                                                                                     |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/50 (4%)                3/50 (6%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  4.9%                     8.1%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      479                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.142N                 P=0.417                  P=0.326N                 P=0.442N        |
|POLY 3             |                  P=0.113N                 P=0.454                  P=0.281N                 P=0.328N        |
|POLY 1.5           |                  P=0.093N                 P=0.472                  P=0.261N                 P=0.285N        |
|POLY 6             |                  P=0.154N                 P=0.433                  P=0.307N                 P=0.392N        |
|LOGISTIC REGRESSION|                  P=0.038N*                P=0.616                  P=0.218N                 P=0.231N        |
|COCH-ARM / FISHERS |                  P=0.073N                 P=0.500                  P=0.247N                 P=0.247N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Interstitium                                                                                                               |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  4/50 (8%)                6/50 (12%)               4/50 (8%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  9.8%                     16.1%                    11.6%                    3.5%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  618                      352                      664                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.389N                 P=0.238                  P=0.432                  P=0.470N        |
|POLY 3             |                  P=0.230N                 P=0.310                  P=0.548                  P=0.301N        |
|POLY 1.5           |                  P=0.159N                 P=0.335                  P=0.589                  P=0.242N        |
|POLY 6             |                  P=0.363N                 P=0.280                  P=0.499                  P=0.396N        |
|LOGISTIC REGRESSION|                  P=0.103N                 P=0.408                  P=0.545                  P=0.197N        |
|COCH-ARM / FISHERS |                  P=0.094N                 P=0.370                  P=0.643N                 P=0.181N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Interstitium                                                                                                               |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.6%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      642                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.553N                 P=0.193                  (e)                      (e)             |
|POLY 3             |                  P=0.489N                 P=0.211                  (e)                      (e)             |
|POLY 1.5           |                  P=0.452N                 P=0.221                  (e)                      (e)             |
|POLY 6             |                  P=0.552N                 P=0.201                  (e)                      (e)             |
|LOGISTIC REGRESSION|                  P=0.444N                 P=0.231                  (e)                      (e)             |
|COCH-ARM / FISHERS |                  P=0.405N                 P=0.247                  (e)                      (e)             |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node                                                                                                                       |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/31 (6%)                1/44 (2%)                0/38 (0%)                0/32 (0%)       |
|POLY-3 ADJUSTED (b)|                  8.2%                     3.2%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  1/13 (8%)                1/12 (8%)                0/8 (0%)                 0/4 (0%)        |
|FIRST INCIDENCE    |                  717                      722 (T)                  ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.235N                 P=0.576N                 P=0.371N                 P=0.521N        |
|POLY 3             |                  P=0.095N                 P=0.416N                 P=0.226N                 P=0.324N        |
|POLY 1.5           |                  P=0.095N                 P=0.398N                 P=0.209N                 P=0.279N        |
|POLY 6             |                  P=0.104N                 P=0.441N                 P=0.249N                 P=0.394N        |
|LOGISTIC REGRESSION|                  P=0.212N                 P=0.509N                 P=0.304N                 P=0.528N        |
|COCH-ARM / FISHERS |                  P=0.096N                 P=0.370N                 P=0.198N                 P=0.238N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node                                                                                                                       |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/31 (6%)                1/44 (2%)                0/38 (0%)                0/32 (0%)       |
|POLY-3 ADJUSTED (b)|                  8.2%                     3.2%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  1/13 (8%)                1/12 (8%)                0/8 (0%)                 0/4 (0%)        |
|FIRST INCIDENCE    |                  717                      722 (T)                  ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.235N                 P=0.576N                 P=0.371N                 P=0.521N        |
|POLY 3             |                  P=0.095N                 P=0.416N                 P=0.226N                 P=0.324N        |
|POLY 1.5           |                  P=0.095N                 P=0.398N                 P=0.209N                 P=0.279N        |
|POLY 6             |                  P=0.104N                 P=0.441N                 P=0.249N                 P=0.394N        |
|LOGISTIC REGRESSION|                  P=0.212N                 P=0.509N                 P=0.304N                 P=0.528N        |
|COCH-ARM / FISHERS |                  P=0.096N                 P=0.370N                 P=0.198N                 P=0.238N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node                                                                                                                       |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/31 (6%)                0/44 (0%)                0/38 (0%)                0/32 (0%)       |
|POLY-3 ADJUSTED (b)|                  8.1%                     0.0%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  1/13 (8%)                0/12 (0%)                0/8 (0%)                 0/4 (0%)        |
|FIRST INCIDENCE    |                  681                      ---                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.199N                 P=0.281N                 P=0.334N                 P=0.477N        |
|POLY 3             |                  P=0.081N                 P=0.183N                 P=0.227N                 P=0.326N        |
|POLY 1.5           |                  P=0.092N                 P=0.173N                 P=0.210N                 P=0.280N        |
|POLY 6             |                  P=0.077N                 P=0.198N                 P=0.252N                 P=0.397N        |
|LOGISTIC REGRESSION|                  P=0.167N                 P=0.209N                 P=0.263N                 P=0.441N        |
|COCH-ARM / FISHERS |                  P=0.109N                 P=0.168N                 P=0.198N                 P=0.238N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/48 (0%)                5/49 (10%)               1/47 (2%)                4/48 (8%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     13.6%                    3.0%                     13.3%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      536                      447                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.098                  P=0.025 *                P=0.496                  P=0.061         |
|POLY 3             |                  P=0.084                  P=0.026 *                P=0.471                  P=0.034 *       |
|POLY 1.5           |                  P=0.111                  P=0.028 *                P=0.481                  P=0.044 *       |
|POLY 6             |                  P=0.055                  P=0.024 *                P=0.459                  P=0.023 *       |
|LOGISTIC REGRESSION|                  P=0.380                  P=0.053                  P=0.551                  P=0.178         |
|COCH-ARM / FISHERS |                  P=0.159                  P=0.030 *                P=0.495                  P=0.059         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  15/48 (31%)              8/49 (16%)               10/47 (21%)              10/48 (21%)     |
|POLY-3 ADJUSTED (b)|                  37.3%                    22.6%                    27.9%                    33.8%           |
|TERMINAL (d)       |                  10/22 (46%)              5/14 (36%)               1/11 (9%)                3/7 (43%)       |
|FIRST INCIDENCE    |                  592                      372                      404                      467             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.115                  P=0.321N                 P=0.560                  P=0.129         |
|POLY 3             |                  P=0.449N                 P=0.122N                 P=0.262N                 P=0.480N        |
|POLY 1.5           |                  P=0.353N                 P=0.094N                 P=0.229N                 P=0.328N        |
|POLY 6             |                  P=0.495                  P=0.172N                 P=0.303N                 P=0.513         |
|LOGISTIC REGRESSION|                  P=0.501N                 P=0.133N                 P=0.239N                 P=0.567         |
|COCH-ARM / FISHERS |                  P=0.240N                 P=0.068N                 P=0.192N                 P=0.176N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/48 (6%)                1/49 (2%)                3/47 (6%)                1/48 (2%)       |
|POLY-3 ADJUSTED (b)|                  7.8%                     2.9%                     9.0%                     3.7%            |
|TERMINAL (d)       |                  2/22 (9%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  644                      647                      575                      627             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.564                  P=0.428N                 P=0.453                  P=0.662N        |
|POLY 3             |                  P=0.431N                 P=0.346N                 P=0.593                  P=0.436N        |
|POLY 1.5           |                  P=0.379N                 P=0.326N                 P=0.618                  P=0.377N        |
|POLY 6             |                  P=0.509N                 P=0.370N                 P=0.566                  P=0.520N        |
|LOGISTIC REGRESSION|                  P=0.430N                 P=0.356N                 P=0.604                  P=0.509N        |
|COCH-ARM / FISHERS |                  P=0.316N                 P=0.301N                 P=0.651                  P=0.308N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  4/48 (8%)                8/49 (16%)               6/47 (13%)               4/48 (8%)       |
|POLY-3 ADJUSTED (b)|                  10.0%                    21.8%                    17.4%                    13.8%           |
|TERMINAL (d)       |                  0/22 (0%)                3/14 (21%)               0/11 (0%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  283                      372                      494                      94              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.284                  P=0.099                  P=0.245                  P=0.337         |
|POLY 3             |                  P=0.425                  P=0.130                  P=0.276                  P=0.459         |
|POLY 1.5           |                  P=0.552                  P=0.151                  P=0.305                  P=0.543         |
|POLY 6             |                  P=0.271                  P=0.110                  P=0.251                  P=0.349         |
|LOGISTIC REGRESSION|                  P=0.252N                 P=0.261                  P=0.471                  P=0.310N        |
|COCH-ARM / FISHERS |                  P=0.416N                 P=0.188                  P=0.356                  P=0.643N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)                2/50 (4%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     8.3%                     5.7%                     3.5%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  601                      552                      487                      568             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.537                  P=0.237                  P=0.436                  P=0.619         |
|POLY 3             |                  P=0.540                  P=0.264                  P=0.449                  P=0.677         |
|POLY 1.5           |                  P=0.562N                 P=0.280                  P=0.470                  P=0.716         |
|POLY 6             |                  P=0.425                  P=0.248                  P=0.423                  P=0.620         |
|LOGISTIC REGRESSION|                  P=0.376N                 P=0.338                  P=0.615                  P=0.728N        |
|COCH-ARM / FISHERS |                  P=0.474N                 P=0.309                  P=0.500                  P=0.753N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  6/50 (12%)               12/50 (24%)              9/50 (18%)               6/50 (12%)      |
|POLY-3 ADJUSTED (b)|                  14.4%                    33.3%                    24.5%                    18.9%           |
|TERMINAL (d)       |                  2/22 (9%)                8/14 (57%)               3/11 (27%)               0/7 (0%)        |
|FIRST INCIDENCE    |                  559                      573                      486                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.149                  P=0.017 *                P=0.094                  P=0.255         |
|POLY 3             |                  P=0.448                  P=0.040 *                P=0.196                  P=0.422         |
|POLY 1.5           |                  P=0.519N                 P=0.059                  P=0.234                  P=0.508         |
|POLY 6             |                  P=0.270                  P=0.023 *                P=0.154                  P=0.308         |
|LOGISTIC REGRESSION|                  P=0.437N                 P=0.044 *                P=0.340                  P=0.429N        |
|COCH-ARM / FISHERS |                  P=0.362N                 P=0.096                  P=0.288                  P=0.620N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  8/50 (16%)               15/50 (30%)              10/50 (20%)              9/50 (18%)      |
|POLY-3 ADJUSTED (b)|                  18.9%                    38.5%                    26.4%                    28.2%           |
|TERMINAL (d)       |                  1/22 (5%)                3/14 (21%)               1/11 (9%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  559                      541                      486                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.097                  P=0.026 *                P=0.174                  P=0.071         |
|POLY 3             |                  P=0.327                  P=0.040 *                P=0.296                  P=0.254         |
|POLY 1.5           |                  P=0.473                  P=0.051                  P=0.337                  P=0.355         |
|POLY 6             |                  P=0.166                  P=0.031 *                P=0.250                  P=0.144         |
|LOGISTIC REGRESSION|                  P=0.430N                 P=0.070                  P=0.492                  P=0.536         |
|COCH-ARM / FISHERS |                  P=0.430N                 P=0.077                  P=0.398                  P=0.500         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                1/50 (2%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.6%                     3.0%                     3.5%            |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      593                      722 (T)                  552             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.270                  P=0.178                  P=0.362                  P=0.417         |
|POLY 3             |                  P=0.347                  P=0.210                  P=0.466                  P=0.434         |
|POLY 1.5           |                  P=0.413                  P=0.221                  P=0.480                  P=0.463         |
|POLY 6             |                  P=0.264                  P=0.199                  P=0.448                  P=0.396         |
|LOGISTIC REGRESSION|                  P=0.434                  P=0.222                  P=0.362                  P=0.581         |
|COCH-ARM / FISHERS |                  P=0.500                  P=0.247                  P=0.500                  P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/46 (0%)                6/50 (12%)               1/50 (2%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     15.8%                    2.9%                     6.9%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      445                      500                      595             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.356                  P=0.013 *                P=0.469                  P=0.107         |
|POLY 3             |                  P=0.363                  P=0.014 *                P=0.479                  P=0.181         |
|POLY 1.5           |                  P=0.466                  P=0.016 *                P=0.495                  P=0.211         |
|POLY 6             |                  P=0.242                  P=0.012 *                P=0.459                  P=0.147         |
|LOGISTIC REGRESSION|                  P=0.428N                 P=0.044 *                P=0.605                  P=0.224         |
|COCH-ARM / FISHERS |                  P=0.585N                 P=0.017 *                P=0.521                  P=0.269         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  5/46 (11%)               6/50 (12%)               6/50 (12%)               5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                  13.0%                    16.1%                    17.2%                    16.3%           |
|TERMINAL (d)       |                  5/22 (23%)               1/14 (7%)                2/11 (18%)               0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  470                      515                      489             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.133                  P=0.286                  P=0.159                  P=0.167         |
|POLY 3             |                  P=0.404                  P=0.480                  P=0.435                  P=0.487         |
|POLY 1.5           |                  P=0.506                  P=0.511                  P=0.487                  P=0.572         |
|POLY 6             |                  P=0.279                  P=0.447                  P=0.375                  P=0.376         |
|LOGISTIC REGRESSION|                  P=0.555                  P=0.520                  P=0.347                  P=0.589         |
|COCH-ARM / FISHERS |                  P=0.482N                 P=0.559                  P=0.559                  P=0.575N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  12/46 (26%)              14/50 (28%)              12/50 (24%)              12/50 (24%)     |
|POLY-3 ADJUSTED (b)|                  29.7%                    35.4%                    31.7%                    35.3%           |
|TERMINAL (d)       |                  2/22 (9%)                2/14 (14%)               2/11 (18%)               1/7 (14%)       |
|FIRST INCIDENCE    |                  616                      445                      515                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.058                  P=0.181                  P=0.244                  P=0.060         |
|POLY 3             |                  P=0.384                  P=0.377                  P=0.521                  P=0.395         |
|POLY 1.5           |                  P=0.518                  P=0.429                  P=0.589                  P=0.522         |
|POLY 6             |                  P=0.223                  P=0.322                  P=0.443                  P=0.240         |
|LOGISTIC REGRESSION|                  P=0.393N                 P=0.499                  P=0.537N                 P=0.471N        |
|COCH-ARM / FISHERS |                  P=0.400N                 P=0.508                  P=0.499N                 P=0.499N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/46 (0%)                2/50 (4%)                0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.5%                     0.0%                     3.6%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  ---                      536                      ---                      722 (T)         |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.365                  P=0.211                  (e)                      P=0.273         |
|POLY 3             |                  P=0.413                  P=0.224                  (e)                      P=0.440         |
|POLY 1.5           |                  P=0.476                  P=0.236                  (e)                      P=0.473         |
|POLY 6             |                  P=0.345                  P=0.210                  (e)                      P=0.395         |
|LOGISTIC REGRESSION|                  P=0.568                  P=0.326                  (e)                      P=0.273         |
|COCH-ARM / FISHERS |                  P=0.556                  P=0.269                  (e)                      P=0.521         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/46 (2%)                1/50 (2%)                2/50 (4%)                5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                  2.6%                     2.9%                     5.8%                     16.1%           |
|TERMINAL (d)       |                  1/22 (5%)                1/14 (7%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  722 (T)                  515                      94              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.004 **               P=0.659                  P=0.360                  P=0.025 *       |
|POLY 3             |                  P=0.016 *                P=0.741                  P=0.464                  P=0.059         |
|POLY 1.5           |                  P=0.023 *                P=0.757                  P=0.492                  P=0.083         |
|POLY 6             |                  P=0.011 *                P=0.720                  P=0.432                  P=0.037 *       |
|LOGISTIC REGRESSION|                  P=0.077                  P=0.659                  P=0.544                  P=0.313         |
|COCH-ARM / FISHERS |                  P=0.033 *                P=0.731N                 P=0.532                  P=0.122         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  5/31 (16%)               3/44 (7%)                3/38 (8%)                1/32 (3%)       |
|POLY-3 ADJUSTED (b)|                  19.9%                    9.6%                     11.8%                    5.6%            |
|TERMINAL (d)       |                  2/13 (15%)               1/12 (8%)                1/8 (13%)                0/4 (0%)        |
|FIRST INCIDENCE    |                  576                      649                      705                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.383N                 P=0.484N                 P=0.630N                 P=0.386N        |
|POLY 3             |                  P=0.137N                 P=0.232N                 P=0.342N                 P=0.195N        |
|POLY 1.5           |                  P=0.109N                 P=0.208N                 P=0.296N                 P=0.141N        |
|POLY 6             |                  P=0.196N                 P=0.270N                 P=0.411N                 P=0.295N        |
|LOGISTIC REGRESSION|                  P=0.210N                 P=0.254N                 P=0.404N                 P=0.158N        |
|COCH-ARM / FISHERS |                  P=0.080N                 P=0.182N                 P=0.246N                 P=0.091N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/31 (3%)                2/44 (5%)                2/38 (5%)                3/32 (9%)       |
|POLY-3 ADJUSTED (b)|                  4.1%                     6.4%                     7.7%                     16.6%           |
|TERMINAL (d)       |                  0/13 (0%)                1/12 (8%)                0/8 (0%)                 0/4 (0%)        |
|FIRST INCIDENCE    |                  717                      714                      622                      468             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.039 *                P=0.393                  P=0.349                  P=0.090         |
|POLY 3             |                  P=0.114                  P=0.584                  P=0.519                  P=0.201         |
|POLY 1.5           |                  P=0.145                  P=0.601                  P=0.542                  P=0.247         |
|POLY 6             |                  P=0.082                  P=0.560                  P=0.489                  P=0.148         |
|LOGISTIC REGRESSION|                  P=0.082                  P=0.502                  P=0.493                  P=0.221         |
|COCH-ARM / FISHERS |                  P=0.194                  P=0.630                  P=0.577                  P=0.319         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/31 (0%)                4/44 (9%)                2/38 (5%)                2/32 (6%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     12.1%                    7.7%                     10.8%           |
|TERMINAL (d)       |                  0/13 (0%)                0/12 (0%)                1/8 (13%)                0/4 (0%)        |
|FIRST INCIDENCE    |                  ---                      352                      515                      468             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.221                  P=0.045 *                P=0.165                  P=0.209         |
|POLY 3             |                  P=0.211                  P=0.099                  P=0.248                  P=0.177         |
|POLY 1.5           |                  P=0.274                  P=0.106                  P=0.264                  P=0.204         |
|POLY 6             |                  P=0.139                  P=0.091                  P=0.229                  P=0.145         |
|LOGISTIC REGRESSION|                  P=0.541                  P=0.133                  P=0.292                  P=0.375         |
|COCH-ARM / FISHERS |                  P=0.366                  P=0.112                  P=0.300                  P=0.254         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/31 (0%)                1/44 (2%)                2/38 (5%)                1/32 (3%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     3.2%                     7.7%                     5.7%            |
|TERMINAL (d)       |                  0/13 (0%)                0/12 (0%)                0/8 (0%)                 0/4 (0%)        |
|FIRST INCIDENCE    |                  ---                      552                      588                      568             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.195                  P=0.463                  P=0.152                  P=0.395         |
|POLY 3             |                  P=0.198                  P=0.552                  P=0.246                  P=0.435         |
|POLY 1.5           |                  P=0.254                  P=0.560                  P=0.263                  P=0.466         |
|POLY 6             |                  P=0.140                  P=0.540                  P=0.227                  P=0.394         |
|LOGISTIC REGRESSION|                  P=0.350                  P=0.595                  P=0.258                  P=0.555         |
|COCH-ARM / FISHERS |                  P=0.337                  P=0.587                  P=0.300                  P=0.508         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Pancreatic                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/31 (6%)                5/44 (11%)               0/38 (0%)                1/32 (3%)       |
|POLY-3 ADJUSTED (b)|                  8.2%                     15.5%                    0.0%                     5.7%            |
|TERMINAL (d)       |                  2/13 (15%)               1/12 (8%)                0/8 (0%)                 0/4 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  479                      ---                      545             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.439N                 P=0.153                  P=0.348N                 P=0.693         |
|POLY 3             |                  P=0.245N                 P=0.333                  P=0.225N                 P=0.613N        |
|POLY 1.5           |                  P=0.208N                 P=0.353                  P=0.209N                 P=0.560N        |
|POLY 6             |                  P=0.306N                 P=0.308                  P=0.249N                 P=0.683N        |
|LOGISTIC REGRESSION|                  P=0.256N                 P=0.317                  (e)                      P=0.661N        |
|COCH-ARM / FISHERS |                  P=0.169N                 P=0.384                  P=0.198N                 P=0.488N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Pancreatic                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  4/31 (13%)               5/44 (11%)               4/38 (11%)               7/32 (22%)      |
|POLY-3 ADJUSTED (b)|                  16.1%                    15.6%                    15.5%                    34.0%           |
|TERMINAL (d)       |                  1/13 (8%)                0/12 (0%)                2/8 (25%)                0/4 (0%)        |
|FIRST INCIDENCE    |                  674                      610                      622                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.016 *                P=0.327                  P=0.389                  P=0.038 *       |
|POLY 3             |                  P=0.085                  P=0.623N                 P=0.626N                 P=0.143         |
|POLY 1.5           |                  P=0.113                  P=0.596N                 P=0.581N                 P=0.192         |
|POLY 6             |                  P=0.056                  P=0.634                  P=0.621                  P=0.093         |
|LOGISTIC REGRESSION|                  P=0.075                  P=0.622                  P=0.588                  P=0.248         |
|COCH-ARM / FISHERS |                  P=0.159                  P=0.556N                 P=0.524N                 P=0.273         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Pancreatic                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/31 (3%)                0/44 (0%)                2/38 (5%)                2/32 (6%)       |
|POLY-3 ADJUSTED (b)|                  4.1%                     0.0%                     7.8%                     10.9%           |
|TERMINAL (d)       |                  0/13 (0%)                0/12 (0%)                1/8 (13%)                0/4 (0%)        |
|FIRST INCIDENCE    |                  674                      ---                      630                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.103                  P=0.562N                 P=0.388                  P=0.346         |
|POLY 3             |                  P=0.147                  P=0.453N                 P=0.515                  P=0.396         |
|POLY 1.5           |                  P=0.173                  P=0.442N                 P=0.541                  P=0.445         |
|POLY 6             |                  P=0.118                  P=0.469N                 P=0.481                  P=0.332         |
|LOGISTIC REGRESSION|                  P=0.210                  P=0.452N                 P=0.505                  P=0.593         |
|COCH-ARM / FISHERS |                  P=0.213                  P=0.413N                 P=0.577                  P=0.512         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Pancreatic                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/31 (6%)                1/44 (2%)                0/38 (0%)                4/32 (13%)      |
|POLY-3 ADJUSTED (b)|                  8.2%                     3.2%                     0.0%                     20.4%           |
|TERMINAL (d)       |                  2/13 (15%)               1/12 (8%)                0/8 (0%)                 0/4 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  722 (T)                  ---                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.050                  P=0.529N                 P=0.348N                 P=0.137         |
|POLY 3             |                  P=0.109                  P=0.415N                 P=0.225N                 P=0.233         |
|POLY 1.5           |                  P=0.117                  P=0.398N                 P=0.209N                 P=0.280         |
|POLY 6             |                  P=0.098                  P=0.440N                 P=0.249N                 P=0.177         |
|LOGISTIC REGRESSION|                  P=0.157                  P=0.529N                 (e)                      P=0.438         |
|COCH-ARM / FISHERS |                  P=0.132                  P=0.370N                 P=0.198N                 P=0.351         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 46
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  15/31 (48%)              20/44 (45%)              16/38 (42%)              10/32 (31%)     |
|POLY-3 ADJUSTED (b)|                  53.0%                    52.9%                    52.8%                    44.5%           |
|TERMINAL (d)       |                  4/13 (31%)               1/12 (8%)                4/8 (50%)                1/4 (25%)       |
|FIRST INCIDENCE    |                  468                      352                      354                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.297                  P=0.101                  P=0.151                  P=0.335         |
|POLY 3             |                  P=0.314N                 P=0.596N                 P=0.600N                 P=0.371N        |
|POLY 1.5           |                  P=0.193N                 P=0.551N                 P=0.498N                 P=0.248N        |
|POLY 6             |                  P=0.531N                 P=0.567                  P=0.484                  P=0.567N        |
|LOGISTIC REGRESSION|                  P=0.064N                 P=0.450N                 P=0.383N                 P=0.093N        |
|COCH-ARM / FISHERS |                  P=0.087N                 P=0.493N                 P=0.390N                 P=0.129N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/31 (0%)                2/44 (5%)                0/38 (0%)                0/32 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     6.3%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/13 (0%)                0/12 (0%)                0/8 (0%)                 0/4 (0%)        |
|FIRST INCIDENCE    |                  ---                      610                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.579N                 P=0.186                  (e)                      (e)             |
|POLY 3             |                  P=0.488N                 P=0.293                  (e)                      (e)             |
|POLY 1.5           |                  P=0.455N                 P=0.304                  (e)                      (e)             |
|POLY 6             |                  P=0.563N                 P=0.279                  (e)                      (e)             |
|LOGISTIC REGRESSION|                  P=0.475N                 P=0.305                  (e)                      (e)             |
|COCH-ARM / FISHERS |                  P=0.415N                 P=0.341                  (e)                      (e)             |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 47
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  10/31 (32%)              17/44 (39%)              19/38 (50%)              12/32 (38%)     |
|POLY-3 ADJUSTED (b)|                  36.1%                    46.0%                    60.4%                    54.8%           |
|TERMINAL (d)       |                  1/13 (8%)                1/12 (8%)                3/8 (38%)                2/4 (50%)       |
|FIRST INCIDENCE    |                  468                      352                      354                      464             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.022 *                P=0.046 *                P=0.009 **               P=0.032 *       |
|POLY 3             |                  P=0.066                  P=0.288                  P=0.045 *                P=0.145         |
|POLY 1.5           |                  P=0.153                  P=0.324                  P=0.067                  P=0.247         |
|POLY 6             |                  P=0.018 *                P=0.253                  P=0.028 *                P=0.063         |
|LOGISTIC REGRESSION|                  P=0.387                  P=0.442                  P=0.134                  P=0.435         |
|COCH-ARM / FISHERS |                  P=0.367                  P=0.375                  P=0.107                  P=0.432         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/31 (0%)                1/44 (2%)                6/38 (16%)               2/32 (6%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     3.2%                     22.6%                    11.3%           |
|TERMINAL (d)       |                  0/13 (0%)                0/12 (0%)                3/8 (38%)                1/4 (25%)       |
|FIRST INCIDENCE    |                  ---                      595                      515                      468             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.023 *                P=0.473                  P=0.005 **               P=0.112         |
|POLY 3             |                  P=0.032 *                P=0.551                  P=0.015 *                P=0.170         |
|POLY 1.5           |                  P=0.061                  P=0.559                  P=0.019 *                P=0.200         |
|POLY 6             |                  P=0.012 *                P=0.539                  P=0.011 *                P=0.136         |
|LOGISTIC REGRESSION|                  P=0.075                  P=0.589                  P=0.018 *                P=0.245         |
|COCH-ARM / FISHERS |                  P=0.129                  P=0.587                  P=0.023 *                P=0.254         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 48
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/31 (0%)                0/44 (0%)                1/38 (3%)                2/32 (6%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     3.9%                     11.1%           |
|TERMINAL (d)       |                  0/13 (0%)                0/12 (0%)                0/8 (0%)                 0/4 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      588                      553             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.028 *                (e)                      P=0.452                  P=0.136         |
|POLY 3             |                  P=0.034 *                (e)                      P=0.511                  P=0.173         |
|POLY 1.5           |                  P=0.040 *                (e)                      P=0.524                  P=0.201         |
|POLY 6             |                  P=0.027 *                (e)                      P=0.494                  P=0.142         |
|LOGISTIC REGRESSION|                  P=0.073                  (e)                      P=0.569                  P=0.287         |
|COCH-ARM / FISHERS |                  P=0.053                  (e)                      P=0.551                  P=0.254         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/31 (0%)                0/44 (0%)                3/38 (8%)                0/32 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     11.7%                    0.0%            |
|TERMINAL (d)       |                  0/13 (0%)                0/12 (0%)                2/8 (25%)                0/4 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      632                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.277                  (e)                      P=0.059                  (e)             |
|POLY 3             |                  P=0.293                  (e)                      P=0.122                  (e)             |
|POLY 1.5           |                  P=0.392                  (e)                      P=0.137                  (e)             |
|POLY 6             |                  P=0.186                  (e)                      P=0.105                  (e)             |
|LOGISTIC REGRESSION|                  P=0.340                  (e)                      P=0.101                  (e)             |
|COCH-ARM / FISHERS |                  P=0.522                  (e)                      P=0.161                  (e)             |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 49
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/48 (0%)                2/46 (4%)                0/44 (0%)                1/46 (2%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     6.0%                     0.0%                     3.8%            |
|TERMINAL (d)       |                  0/21 (0%)                0/14 (0%)                0/10 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      506                      ---                      660             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.389                  P=0.208                  (e)                      P=0.342         |
|POLY 3             |                  P=0.406                  P=0.207                  (e)                      P=0.428         |
|POLY 1.5           |                  P=0.460                  P=0.215                  (e)                      P=0.456         |
|POLY 6             |                  P=0.334                  P=0.197                  (e)                      P=0.390         |
|LOGISTIC REGRESSION|                  P=0.563                  P=0.269                  (e)                      P=0.418         |
|COCH-ARM / FISHERS |                  P=0.529                  P=0.237                  (e)                      P=0.489         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  4/48 (8%)                0/46 (0%)                2/44 (5%)                4/46 (9%)       |
|POLY-3 ADJUSTED (b)|                  10.2%                    0.0%                     6.7%                     14.1%           |
|TERMINAL (d)       |                  1/21 (5%)                0/14 (0%)                1/10 (10%)               0/7 (0%)        |
|FIRST INCIDENCE    |                  536                      ---                      494                      94              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.145                  P=0.107N                 P=0.555N                 P=0.307         |
|POLY 3             |                  P=0.282                  P=0.088N                 P=0.469N                 P=0.456         |
|POLY 1.5           |                  P=0.316                  P=0.078N                 P=0.430N                 P=0.533         |
|POLY 6             |                  P=0.238                  P=0.103N                 P=0.517N                 P=0.354         |
|LOGISTIC REGRESSION|                  P=0.528                  P=0.059N                 P=0.341N                 P=0.437N        |
|COCH-ARM / FISHERS |                  P=0.354                  P=0.064N                 P=0.381N                 P=0.619         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 50
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland: Artery                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/48 (6%)                5/46 (11%)               0/44 (0%)                0/46 (0%)       |
|POLY-3 ADJUSTED (b)|                  7.6%                     14.5%                    0.0%                     0.0%            |
|TERMINAL (d)       |                  0/21 (0%)                0/14 (0%)                0/10 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      479                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.079N                 P=0.271                  P=0.186N                 P=0.293N        |
|POLY 3             |                  P=0.061N                 P=0.287                  P=0.178N                 P=0.207N        |
|POLY 1.5           |                  P=0.042N*                P=0.305                  P=0.158N                 P=0.167N        |
|POLY 6             |                  P=0.102N                 P=0.267                  P=0.205N                 P=0.274N        |
|LOGISTIC REGRESSION|                  P=0.016N*                P=0.417                  P=0.113N                 P=0.108N        |
|COCH-ARM / FISHERS |                  P=0.029N*                P=0.333                  P=0.138N                 P=0.129N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland: Duct                                                                                                              |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  6/48 (13%)               7/46 (15%)               5/44 (11%)               4/46 (9%)       |
|POLY-3 ADJUSTED (b)|                  15.1%                    20.7%                    16.4%                    14.6%           |
|TERMINAL (d)       |                  2/21 (10%)               3/14 (21%)               0/10 (0%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  468                      486                      520                      562             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.360                  P=0.295                  P=0.489                  P=0.423         |
|POLY 3             |                  P=0.495N                 P=0.375                  P=0.573                  P=0.610N        |
|POLY 1.5           |                  P=0.392N                 P=0.414                  P=0.622                  P=0.518N        |
|POLY 6             |                  P=0.455                  P=0.328                  P=0.519                  P=0.533         |
|LOGISTIC REGRESSION|                  P=0.392N                 P=0.447                  P=0.595N                 P=0.482N        |
|COCH-ARM / FISHERS |                  P=0.270N                 P=0.467                  P=0.562N                 P=0.398N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 51
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  5/7 (71%)                1/1 (100%)               0/2 (0%)                 1/2 (50%)       |
|POLY-3 ADJUSTED (b)|                  72.3%                    100.0%                   0.0%                     60.0%           |
|TERMINAL (d)       |                  0/1 (0%)                 0/0 (0%)                 0/1 (0%)                 0/0 (0%)        |
|FIRST INCIDENCE    |                  468                      573                      ---                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.167N                 P=0.200N                 P=0.098N                 P=0.384N        |
|POLY 3             |                  P=0.307N                 P=0.720                  P=0.157N                 P=0.710N        |
|POLY 1.5           |                  P=0.287N                 P=0.714                  P=0.148N                 P=0.659N        |
|POLY 6             |                  P=0.342N                 P=0.732                  P=0.176N                 P=0.786N        |
|LOGISTIC REGRESSION|                  P=0.049N*                (e)                      P=0.228N                 P=0.342N        |
|COCH-ARM / FISHERS |                  P=0.268N                 P=0.750                  P=0.167N                 P=0.583N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/7 (29%)                0/1 (0%)                 0/2 (0%)                 0/2 (0%)        |
|POLY-3 ADJUSTED (b)|                  35.2%                    0.0%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/1 (0%)                 0/0 (0%)                 0/1 (0%)                 0/0 (0%)        |
|FIRST INCIDENCE    |                  701                      ---                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.233N                 P=0.341N                 P=0.402N                 P=0.516N        |
|POLY 3             |                  P=0.278N                 P=0.785N                 P=0.507N                 P=0.658N        |
|POLY 1.5           |                  P=0.252N                 P=0.750N                 P=0.520N                 P=0.606N        |
|POLY 6             |                  P=0.323N                 P=0.834N                 P=0.496N                 P=0.724N        |
|LOGISTIC REGRESSION|                  P=0.442N                 (e)                      P=0.474N                 (e)             |
|COCH-ARM / FISHERS |                  P=0.273N                 P=0.750N                 P=0.583N                 P=0.583N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 52
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Vein                                                                                                                  |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/7 (0%)                 0/1 (0%)                 2/2 (100%)               0/2 (0%)        |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     100.0%                   0.0%            |
|TERMINAL (d)       |                  0/1 (0%)                 0/0 (0%)                 1/1 (100%)               0/0 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      683                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.311                  (e)                      P=0.196                  (e)             |
|POLY 3             |                  P<0.001 **               (e)                      P<0.001 **               (e)             |
|POLY 1.5           |                  P<0.001 **               (e)                      P<0.001 **               (e)             |
|POLY 6             |                  P<0.001 **               (e)                      P<0.001 **               (e)             |
|LOGISTIC REGRESSION|                  P=0.097                  (e)                      P=0.033 *                (e)             |
|COCH-ARM / FISHERS |                  P=0.333                  (e)                      P=0.028 *                (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  11/50 (22%)              4/50 (8%)                6/50 (12%)               1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  26.1%                    11.0%                    15.7%                    3.5%            |
|TERMINAL (d)       |                  4/22 (18%)               2/14 (14%)               0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  592                      336                      354                      467             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.049N*                P=0.156N                 P=0.363N                 P=0.086N        |
|POLY 3             |                  P=0.012N*                P=0.077N                 P=0.191N                 P=0.014N*       |
|POLY 1.5           |                  P=0.007N**               P=0.060N                 P=0.166N                 P=0.006N**      |
|POLY 6             |                  P=0.028N*                P=0.106N                 P=0.233N                 P=0.045N*       |
|LOGISTIC REGRESSION|                  P<0.001N**               P=0.053N                 P=0.056N                 P=0.007N**      |
|COCH-ARM / FISHERS |                  P=0.004N**               P=0.045N*                P=0.143N                 P=0.002N**      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 53
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/50 (6%)                0/50 (0%)                1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  7.5%                     0.0%                     2.9%                     0.0%            |
|TERMINAL (d)       |                  2/22 (9%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  717                      ---                      487                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.207N                 P=0.216N                 P=0.508N                 P=0.384N        |
|POLY 3             |                  P=0.096N                 P=0.143N                 P=0.361N                 P=0.195N        |
|POLY 1.5           |                  P=0.090N                 P=0.133N                 P=0.337N                 P=0.157N        |
|POLY 6             |                  P=0.109N                 P=0.157N                 P=0.391N                 P=0.258N        |
|LOGISTIC REGRESSION|                  P=0.116N                 P=0.191N                 P=0.342N                 P=0.370N        |
|COCH-ARM / FISHERS |                  P=0.086N                 P=0.121N                 P=0.309N                 P=0.121N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  7/50 (14%)               7/50 (14%)               4/50 (8%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  16.7%                    18.6%                    11.1%                    6.8%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  589                      352                      473                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.208N                 P=0.433                  P=0.421N                 P=0.364N        |
|POLY 3             |                  P=0.112N                 P=0.529                  P=0.350N                 P=0.196N        |
|POLY 1.5           |                  P=0.072N                 P=0.565                  P=0.310N                 P=0.134N        |
|POLY 6             |                  P=0.199N                 P=0.481                  P=0.408N                 P=0.310N        |
|LOGISTIC REGRESSION|                  P=0.014N*                P=0.549N                 P=0.164N                 P=0.056N        |
|COCH-ARM / FISHERS |                  P=0.040N*                P=0.613N                 P=0.262N                 P=0.080N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 54
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  11/50 (22%)              7/50 (14%)               7/50 (14%)               7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                  26.5%                    18.6%                    19.4%                    22.9%           |
|TERMINAL (d)       |                  8/22 (36%)               3/14 (21%)               2/11 (18%)               2/7 (29%)       |
|FIRST INCIDENCE    |                  468                      336                      354                      464             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.286                  P=0.490N                 P=0.581                  P=0.291         |
|POLY 3             |                  P=0.405N                 P=0.285N                 P=0.317N                 P=0.469N        |
|POLY 1.5           |                  P=0.317N                 P=0.254N                 P=0.270N                 P=0.349N        |
|POLY 6             |                  P=0.533N                 P=0.328N                 P=0.383N                 P=0.582         |
|LOGISTIC REGRESSION|                  P=0.234N                 P=0.217N                 P=0.242N                 P=0.433N        |
|COCH-ARM / FISHERS |                  P=0.217N                 P=0.218N                 P=0.218N                 P=0.218N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                1/50 (2%)                1/50 (2%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     2.8%                     3.0%                     6.9%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      639                      721                      467             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.052                  P=0.462                  P=0.379                  P=0.137         |
|POLY 3             |                  P=0.094                  P=0.475                  P=0.466                  P=0.173         |
|POLY 1.5           |                  P=0.117                  P=0.485                  P=0.480                  P=0.199         |
|POLY 6             |                  P=0.068                  P=0.464                  P=0.448                  P=0.142         |
|LOGISTIC REGRESSION|                  P=0.133                  P=0.503                  P=0.383                  P=0.285         |
|COCH-ARM / FISHERS |                  P=0.153                  P=0.500                  P=0.500                  P=0.247         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 55
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     5.7%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      479                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.561                  (e)                      P=0.221                  (e)             |
|POLY 3             |                  P=0.409                  (e)                      P=0.208                  (e)             |
|POLY 1.5           |                  P=0.495                  (e)                      P=0.220                  (e)             |
|POLY 6             |                  P=0.300                  (e)                      P=0.195                  (e)             |
|LOGISTIC REGRESSION|                  P=0.631N                 (e)                      P=0.318                  (e)             |
|COCH-ARM / FISHERS |                  P=0.595                  (e)                      P=0.247                  (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  20/50 (40%)              9/50 (18%)               12/50 (24%)              15/50 (30%)     |
|POLY-3 ADJUSTED (b)|                  46.4%                    24.0%                    32.1%                    43.0%           |
|TERMINAL (d)       |                  11/22 (50%)              2/14 (14%)               2/11 (18%)               2/7 (29%)       |
|FIRST INCIDENCE    |                  557                      336                      486                      94              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.054                  P=0.138N                 P=0.492N                 P=0.084         |
|POLY 3             |                  P=0.515N                 P=0.027N*                P=0.134N                 P=0.469N        |
|POLY 1.5           |                  P=0.427N                 P=0.019N*                P=0.099N                 P=0.333N        |
|POLY 6             |                  P=0.453                  P=0.041N*                P=0.184N                 P=0.546         |
|LOGISTIC REGRESSION|                  P=0.419N                 P=0.023N*                P=0.120N                 P=0.269N        |
|COCH-ARM / FISHERS |                  P=0.335N                 P=0.013N*                P=0.066N                 P=0.201N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 56
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/5 (60%)                0/1 (0%)                 0/1 (0%)                 0/0 (0%)        |
|POLY-3 ADJUSTED (b)|                  66.0%                    0.0%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  1/2 (50%)                0/1 (0%)                 0/0 (0%)                 0/0 (0%)        |
|FIRST INCIDENCE    |                  654                      ---                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.185N                 P=0.236N                 P=0.378N                 P=0.525N        |
|POLY 3             |                  P=1.000                  P=0.463N                 P=0.499N                 P=1.000N        |
|POLY 1.5           |                  P=1.000                  P=0.480N                 P=0.497N                 P=1.000N        |
|POLY 6             |                  P=1.000                  P=0.437N                 P=0.513N                 P=1.000N        |
|LOGISTIC REGRESSION|                  P=0.353N                 P=0.448N                 P=0.459N                 (e)             |
|COCH-ARM / FISHERS |                  P=0.382N                 P=0.500N                 P=0.500N                 P=1.000         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/46 (4%)                3/50 (6%)                3/50 (6%)                1/49 (2%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     8.5%                     8.7%                     3.6%            |
|TERMINAL (d)       |                  1/22 (5%)                2/14 (14%)               1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  468                      638                      630                      595             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.495                  P=0.360                  P=0.338                  P=0.709N        |
|POLY 3             |                  P=0.491N                 P=0.471                  P=0.457                  P=0.599N        |
|POLY 1.5           |                  P=0.415N                 P=0.498                  P=0.491                  P=0.547N        |
|POLY 6             |                  P=0.537                  P=0.438                  P=0.417                  P=0.668N        |
|LOGISTIC REGRESSION|                  P=0.428N                 P=0.518                  P=0.535                  P=0.421N        |
|COCH-ARM / FISHERS |                  P=0.324N                 P=0.540                  P=0.540                  P=0.476N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 57
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  18/46 (39%)              18/50 (36%)              8/50 (16%)               8/49 (16%)      |
|POLY-3 ADJUSTED (b)|                  46.2%                    45.4%                    22.7%                    26.7%           |
|TERMINAL (d)       |                  12/22 (55%)              8/14 (57%)               5/11 (46%)               2/7 (29%)       |
|FIRST INCIDENCE    |                  572                      352                      501                      483             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.452N                 P=0.158                  P=0.298N                 P=0.467         |
|POLY 3             |                  P=0.017N*                P=0.565N                 P=0.025N*                P=0.073N        |
|POLY 1.5           |                  P=0.007N**               P=0.517N                 P=0.015N*                P=0.032N*       |
|POLY 6             |                  P=0.053N                 P=0.566                  P=0.046N*                P=0.192N        |
|LOGISTIC REGRESSION|                  P=0.023N*                P=0.585                  P=0.039N*                P=0.169N        |
|COCH-ARM / FISHERS |                  P=0.003N**               P=0.458N                 P=0.010N*                P=0.012N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/46 (7%)                5/50 (10%)               3/50 (6%)                0/49 (0%)       |
|POLY-3 ADJUSTED (b)|                  8.0%                     13.7%                    8.7%                     0.0%            |
|TERMINAL (d)       |                  2/22 (9%)                2/14 (14%)               0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  639                      506                      630                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.277N                 P=0.209                  P=0.466                  P=0.353N        |
|POLY 3             |                  P=0.139N                 P=0.342                  P=0.628                  P=0.181N        |
|POLY 1.5           |                  P=0.094N                 P=0.367                  P=0.659                  P=0.144N        |
|POLY 6             |                  P=0.237N                 P=0.314                  P=0.589                  P=0.245N        |
|LOGISTIC REGRESSION|                  P=0.094N                 P=0.370                  P=0.619                  P=0.246N        |
|COCH-ARM / FISHERS |                  P=0.056N                 P=0.405                  P=0.621N                 P=0.110N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 58
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/46 (4%)                6/50 (12%)               1/50 (2%)                0/49 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     16.3%                    2.9%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  576                      561                      675                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.227N                 P=0.076                  P=0.643N                 P=0.446N        |
|POLY 3             |                  P=0.122N                 P=0.123                  P=0.535N                 P=0.310N        |
|POLY 1.5           |                  P=0.083N                 P=0.137                  P=0.507N                 P=0.269N        |
|POLY 6             |                  P=0.206N                 P=0.109                  P=0.570N                 P=0.375N        |
|LOGISTIC REGRESSION|                  P=0.068N                 P=0.161                  P=0.500N                 P=0.257N        |
|COCH-ARM / FISHERS |                  P=0.053N                 P=0.163                  P=0.468N                 P=0.232N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  16/48 (33%)              32/47 (68%)              29/48 (60%)              12/47 (26%)     |
|POLY-3 ADJUSTED (b)|                  38.0%                    75.7%                    67.1%                    36.6%           |
|TERMINAL (d)       |                  5/22 (23%)               7/13 (54%)               2/11 (18%)               0/7 (0%)        |
|FIRST INCIDENCE    |                  536                      372                      354                      483             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.159                  P<0.001 **               P<0.001 **               P=0.184         |
|POLY 3             |                  P=0.376N                 P<0.001 **               P=0.004 **               P=0.547N        |
|POLY 1.5           |                  P=0.186N                 P<0.001 **               P=0.004 **               P=0.425N        |
|POLY 6             |                  P=0.419                  P<0.001 **               P=0.005 **               P=0.492         |
|LOGISTIC REGRESSION|                  P=0.044N*                P<0.001 **               P=0.013 *                P=0.222N        |
|COCH-ARM / FISHERS |                  P=0.057N                 P<0.001 **               P=0.007 **               P=0.272N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 59
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Peripheral Nerve                                                                                                                 |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/1 (0%)                 2/4 (50%)                2/2 (100%)               0/5 (0%)        |
|POLY-3 ADJUSTED (b)|                  0.0%                     63.0%                    100.0%                   0.0%            |
|TERMINAL (d)       |                  0/1 (0%)                 0/0 (0%)                 0/0 (0%)                 0/1 (0%)        |
|FIRST INCIDENCE    |                  ---                      541                      501                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.585                  P=0.200                  P=0.158                  (e)             |
|POLY 3             |                  P=0.367N                 P=0.520                  P=1.000N                 (e)             |
|POLY 1.5           |                  P=0.197N                 P=0.548                  P=1.000N                 (e)             |
|POLY 6             |                  P=0.744                  P=0.474                  P=1.000N                 (e)             |
|LOGISTIC REGRESSION|                  P=0.159N                 P=0.797                  (e)                      (e)             |
|COCH-ARM / FISHERS |                  P=0.169N                 P=0.600                  P=0.333                  (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Peripheral Nerve                                                                                                                 |
|     Radicular Neuropathy                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/1 (0%)                 4/4 (100%)               1/2 (50%)                2/5 (40%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     100.0%                   75.0%                    54.6%           |
|TERMINAL (d)       |                  0/1 (0%)                 0/0 (0%)                 0/0 (0%)                 0/1 (0%)        |
|FIRST INCIDENCE    |                  ---                      506                      721                      582             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.166                  P=0.042 *                P=0.379                  P=0.099         |
|POLY 3             |                  P=0.532N                 P=1.000N                 P=0.568                  P=0.567         |
|POLY 1.5           |                  P=0.400N                 P=1.000N                 P=0.591                  P=0.598         |
|POLY 6             |                  P=0.699N                 P=1.000N                 P=0.530                  P=0.527         |
|LOGISTIC REGRESSION|                  P=0.334N                 (e)                      P=0.497                  P=0.687         |
|COCH-ARM / FISHERS |                  P=0.300N                 P=0.200                  P=0.667                  P=0.667         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 60
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/49 (0%)                0/49 (0%)                0/50 (0%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     0.0%                     7.1%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  ---                      ---                      ---                      682             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.009 **               (e)                      (e)                      P=0.065         |
|POLY 3             |                  P=0.037 *                (e)                      (e)                      P=0.172         |
|POLY 1.5           |                  P=0.040 *                (e)                      (e)                      P=0.200         |
|POLY 6             |                  P=0.036 *                (e)                      (e)                      P=0.139         |
|LOGISTIC REGRESSION|                  P=0.011 *                (e)                      (e)                      P=0.078         |
|COCH-ARM / FISHERS |                  P=0.048 *                (e)                      (e)                      P=0.253         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  17/49 (35%)              13/49 (27%)              18/50 (36%)              11/50 (22%)     |
|POLY-3 ADJUSTED (b)|                  40.3%                    33.9%                    44.8%                    34.8%           |
|TERMINAL (d)       |                  8/22 (36%)               5/14 (36%)               3/11 (27%)               2/7 (29%)       |
|FIRST INCIDENCE    |                  536                      336                      354                      467             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.129                  P=0.533                  P=0.109                  P=0.172         |
|POLY 3             |                  P=0.465N                 P=0.355N                 P=0.424                  P=0.403N        |
|POLY 1.5           |                  P=0.308N                 P=0.307N                 P=0.470                  P=0.253N        |
|POLY 6             |                  P=0.389                  P=0.427N                 P=0.374                  P=0.570         |
|LOGISTIC REGRESSION|                  P=0.208N                 P=0.272N                 P=0.525                  P=0.405N        |
|COCH-ARM / FISHERS |                  P=0.147N                 P=0.256N                 P=0.530                  P=0.119N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 61
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  13/49 (27%)              10/49 (20%)              7/50 (14%)               3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                  31.2%                    28.0%                    19.9%                    10.4%           |
|TERMINAL (d)       |                  6/22 (27%)               6/14 (43%)               4/11 (36%)               1/7 (14%)       |
|FIRST INCIDENCE    |                  589                      536                      479                      489             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.207N                 P=0.520                  P=0.458N                 P=0.261N        |
|POLY 3             |                  P=0.020N*                P=0.476N                 P=0.190N                 P=0.039N*       |
|POLY 1.5           |                  P=0.008N**               P=0.406N                 P=0.142N                 P=0.016N*       |
|POLY 6             |                  P=0.067N                 P=0.567N                 P=0.271N                 P=0.117N        |
|LOGISTIC REGRESSION|                  P=0.024N*                P=0.455N                 P=0.162N                 P=0.037N*       |
|COCH-ARM / FISHERS |                  P=0.003N**               P=0.317N                 P=0.096N                 P=0.005N**      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/49 (4%)                1/49 (2%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.1%                     2.8%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  2/22 (9%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  372                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.185N                 P=0.606N                 P=0.400N                 P=0.512N        |
|POLY 3             |                  P=0.109N                 P=0.540N                 P=0.273N                 P=0.319N        |
|POLY 1.5           |                  P=0.104N                 P=0.523N                 P=0.255N                 P=0.279N        |
|POLY 6             |                  P=0.122N                 P=0.562N                 P=0.296N                 P=0.382N        |
|LOGISTIC REGRESSION|                  P=0.080N                 P=0.451N                 (e)                      (e)             |
|COCH-ARM / FISHERS |                  P=0.098N                 P=0.500N                 P=0.242N                 P=0.242N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 62
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  12/50 (24%)              9/48 (19%)               10/50 (20%)              3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                  27.9%                    24.6%                    27.0%                    10.3%           |
|TERMINAL (d)       |                  6/22 (27%)               1/13 (8%)                1/11 (9%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  468                      479                      473                      580             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.265N                 P=0.579                  P=0.378                  P=0.260N        |
|POLY 3             |                  P=0.080N                 P=0.467N                 P=0.565N                 P=0.067N        |
|POLY 1.5           |                  P=0.036N*                P=0.420N                 P=0.497N                 P=0.032N*       |
|POLY 6             |                  P=0.200N                 P=0.518N                 P=0.564                  P=0.160N        |
|LOGISTIC REGRESSION|                  P=0.013N*                P=0.295N                 P=0.379N                 P=0.022N*       |
|COCH-ARM / FISHERS |                  P=0.012N*                P=0.350N                 P=0.405N                 P=0.011N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/50 (6%)                2/48 (4%)                4/50 (8%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  7.5%                     5.9%                     11.3%                    3.5%            |
|TERMINAL (d)       |                  2/22 (9%)                0/13 (0%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  707                      470                      354                      511             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.588                  P=0.653N                 P=0.269                  P=0.646N        |
|POLY 3             |                  P=0.440N                 P=0.576N                 P=0.432                  P=0.432N        |
|POLY 1.5           |                  P=0.369N                 P=0.553N                 P=0.462                  P=0.374N        |
|POLY 6             |                  P=0.549N                 P=0.604N                 P=0.396                  P=0.516N        |
|LOGISTIC REGRESSION|                  P=0.255N                 P=0.567N                 P=0.522                  P=0.457N        |
|COCH-ARM / FISHERS |                  P=0.287N                 P=0.520N                 P=0.500                  P=0.309N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 63
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  49/50 (98%)              43/48 (90%)              46/50 (92%)              48/50 (96%)     |
|POLY-3 ADJUSTED (b)|                  98.4%                    91.4%                    93.2%                    98.7%           |
|TERMINAL (d)       |                  22/22 (100%)             12/13 (92%)              8/11 (73%)               7/7 (100%)      |
|FIRST INCIDENCE    |                  283                      336                      354                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               P=0.164                  P=0.037 *                P<0.001 **      |
|POLY 3             |                  P=0.389                  P=0.115N                 P=0.207N                 P=0.786         |
|POLY 1.5           |                  P=0.401                  P=0.103N                 P=0.197N                 P=0.784         |
|POLY 6             |                  P=0.396                  P=0.141N                 P=0.210N                 P=0.823         |
|LOGISTIC REGRESSION|                  P=0.570                  P=0.066N                 P=0.130N                 P=0.736         |
|COCH-ARM / FISHERS |                  P=0.572                  P=0.093N                 P=0.181N                 P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                0/49 (0%)                2/50 (4%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     5.8%                     3.5%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      354                      631             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.130                  (e)                      P=0.177                  P=0.344         |
|POLY 3             |                  P=0.145                  (e)                      P=0.205                  P=0.433         |
|POLY 1.5           |                  P=0.187                  (e)                      P=0.219                  P=0.462         |
|POLY 6             |                  P=0.102                  (e)                      P=0.189                  P=0.394         |
|LOGISTIC REGRESSION|                  P=0.312                  (e)                      P=0.311                  P=0.480         |
|COCH-ARM / FISHERS |                  P=0.247                  (e)                      P=0.247                  P=0.500         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 64
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  4/50 (8%)                4/49 (8%)                1/50 (2%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  10.0%                    11.7%                    3.0%                     7.1%            |
|TERMINAL (d)       |                  4/22 (18%)               3/14 (21%)               1/11 (9%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  722 (T)                  710                      722 (T)                  658             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.525                  P=0.391                  P=0.433N                 P=0.513         |
|POLY 3             |                  P=0.278N                 P=0.555                  P=0.233N                 P=0.505N        |
|POLY 1.5           |                  P=0.234N                 P=0.587                  P=0.209N                 P=0.429N        |
|POLY 6             |                  P=0.348N                 P=0.516                  P=0.266N                 P=0.610N        |
|LOGISTIC REGRESSION|                  P=0.591                  P=0.415                  P=0.433N                 P=0.570         |
|COCH-ARM / FISHERS |                  P=0.184N                 P=0.631                  P=0.181N                 P=0.339N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/50 (6%)                1/49 (2%)                0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  7.4%                     2.9%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  2/22 (9%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      486                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.101N                 P=0.418N                 P=0.235N                 P=0.325N        |
|POLY 3             |                  P=0.048N*                P=0.361N                 P=0.154N                 P=0.198N        |
|POLY 1.5           |                  P=0.045N*                P=0.341N                 P=0.138N                 P=0.159N        |
|POLY 6             |                  P=0.056N                 P=0.386N                 P=0.177N                 P=0.264N        |
|LOGISTIC REGRESSION|                  P=0.038N*                P=0.280N                 P=0.141N                 P=0.187N        |
|COCH-ARM / FISHERS |                  P=0.044N*                P=0.316N                 P=0.121N                 P=0.121N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 65
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  8/50 (16%)               9/49 (18%)               7/50 (14%)               4/50 (8%)       |
|POLY-3 ADJUSTED (b)|                  19.3%                    24.1%                    20.1%                    13.3%           |
|TERMINAL (d)       |                  3/22 (14%)               0/14 (0%)                3/11 (27%)               0/7 (0%)        |
|FIRST INCIDENCE    |                  468                      352                      561                      466             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.500                  P=0.278                  P=0.345                  P=0.591         |
|POLY 3             |                  P=0.284N                 P=0.401                  P=0.580                  P=0.365N        |
|POLY 1.5           |                  P=0.191N                 P=0.433                  P=0.586N                 P=0.274N        |
|POLY 6             |                  P=0.442N                 P=0.372                  P=0.509                  P=0.503N        |
|LOGISTIC REGRESSION|                  P=0.150N                 P=0.498                  P=0.584                  P=0.212N        |
|COCH-ARM / FISHERS |                  P=0.105N                 P=0.482                  P=0.500N                 P=0.178N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands: Artery                                                                                                          |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/48 (4%)                3/49 (6%)                0/47 (0%)                0/48 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.1%                     8.6%                     0.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  601                      639                      ---                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.196N                 P=0.384                  P=0.314N                 P=0.457N        |
|POLY 3             |                  P=0.111N                 P=0.450                  P=0.279N                 P=0.326N        |
|POLY 1.5           |                  P=0.093N                 P=0.474                  P=0.263N                 P=0.284N        |
|POLY 6             |                  P=0.147N                 P=0.423                  P=0.300N                 P=0.388N        |
|LOGISTIC REGRESSION|                  P=0.101N                 P=0.477                  P=0.244N                 P=0.276N        |
|COCH-ARM / FISHERS |                  P=0.074N                 P=0.510                  P=0.253N                 P=0.247N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 66
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     5.5%                     2.9%                     0.0%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  506                      674                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.429N                 P=0.422                  P=0.646                  P=0.727N        |
|POLY 3             |                  P=0.345N                 P=0.463                  P=0.723                  P=0.569N        |
|POLY 1.5           |                  P=0.300N                 P=0.478                  P=0.739                  P=0.539N        |
|POLY 6             |                  P=0.423N                 P=0.447                  P=0.702                  P=0.610N        |
|LOGISTIC REGRESSION|                  P=0.262N                 P=0.529                  P=0.695                  (e)             |
|COCH-ARM / FISHERS |                  P=0.247N                 P=0.500                  P=0.753N                 P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                1/50 (2%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.7%                     2.9%                     7.1%            |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                0/11 (0%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  ---                      710                      548                      687             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.058                  P=0.162                  P=0.447                  P=0.049 *       |
|POLY 3             |                  P=0.144                  P=0.208                  P=0.469                  P=0.169         |
|POLY 1.5           |                  P=0.184                  P=0.220                  P=0.482                  P=0.196         |
|POLY 6             |                  P=0.103                  P=0.195                  P=0.454                  P=0.136         |
|LOGISTIC REGRESSION|                  P=0.116                  P=0.166                  P=0.562                  P=0.072         |
|COCH-ARM / FISHERS |                  P=0.245                  P=0.247                  P=0.500                  P=0.247         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 67
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     5.7%                     0.0%                     3.6%            |
|TERMINAL (d)       |                  1/22 (5%)                1/14 (7%)                0/11 (0%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  722 (T)                  710                      ---                      722 (T)         |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.460                  P=0.362                  P=0.638N                 P=0.488         |
|POLY 3             |                  P=0.565N                 P=0.454                  P=0.534N                 P=0.676         |
|POLY 1.5           |                  P=0.537N                 P=0.473                  P=0.520N                 P=0.715         |
|POLY 6             |                  P=0.596                  P=0.431                  P=0.552N                 P=0.615         |
|LOGISTIC REGRESSION|                  P=0.485                  P=0.377                  (e)                      P=0.488         |
|COCH-ARM / FISHERS |                  P=0.500N                 P=0.500                  P=0.500N                 P=0.753N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)                0/50 (0%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     2.8%                     0.0%                     6.9%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  552                      ---                      468             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.212                  P=0.688                  P=0.638N                 P=0.276         |
|POLY 3             |                  P=0.303                  P=0.734                  P=0.534N                 P=0.391         |
|POLY 1.5           |                  P=0.330                  P=0.745                  P=0.520N                 P=0.438         |
|POLY 6             |                  P=0.270                  P=0.722                  P=0.552N                 P=0.330         |
|LOGISTIC REGRESSION|                  P=0.415                  P=0.761N                 (e)                      P=0.531         |
|COCH-ARM / FISHERS |                  P=0.366                  P=0.753N                 P=0.500N                 P=0.500         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 68
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/49 (4%)                1/50 (2%)                1/49 (2%)                1/49 (2%)       |
|POLY-3 ADJUSTED (b)|                  5.0%                     2.8%                     3.0%                     3.6%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      541                      628                      660             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.597N                 P=0.559N                 P=0.574N                 P=0.723N        |
|POLY 3             |                  P=0.479N                 P=0.541N                 P=0.563N                 P=0.622N        |
|POLY 1.5           |                  P=0.449N                 P=0.521N                 P=0.536N                 P=0.569N        |
|POLY 6             |                  P=0.525N                 P=0.565N                 P=0.594N                 P=0.689N        |
|LOGISTIC REGRESSION|                  P=0.360N                 P=0.406N                 P=0.436N                 P=0.467N        |
|COCH-ARM / FISHERS |                  P=0.411N                 P=0.492N                 P=0.500N                 P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/49 (2%)                2/50 (4%)                0/49 (0%)                2/49 (4%)       |
|POLY-3 ADJUSTED (b)|                  2.5%                     5.6%                     0.0%                     7.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  572                      552                      ---                      539             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.291                  P=0.427                  P=0.556N                 P=0.305         |
|POLY 3             |                  P=0.369                  P=0.464                  P=0.536N                 P=0.387         |
|POLY 1.5           |                  P=0.411                  P=0.481                  P=0.520N                 P=0.436         |
|POLY 6             |                  P=0.315                  P=0.444                  P=0.554N                 P=0.325         |
|LOGISTIC REGRESSION|                  P=0.503                  P=0.557                  P=0.450N                 P=0.558         |
|COCH-ARM / FISHERS |                  P=0.467                  P=0.508                  P=0.500N                 P=0.500         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 69
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)                1/50 (2%)                2/49 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     2.9%                     7.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      683                      580             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.021 *                (e)                      P=0.430                  P=0.119         |
|POLY 3             |                  P=0.043 *                (e)                      P=0.467                  P=0.171         |
|POLY 1.5           |                  P=0.053                  (e)                      P=0.482                  P=0.196         |
|POLY 6             |                  P=0.034 *                (e)                      P=0.450                  P=0.142         |
|LOGISTIC REGRESSION|                  P=0.059                  (e)                      P=0.455                  P=0.269         |
|COCH-ARM / FISHERS |                  P=0.069                  (e)                      P=0.505                  P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)                1/50 (2%)                2/49 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     2.9%                     6.9%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      479                      466             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.062                  (e)                      P=0.492                  P=0.216         |
|POLY 3             |                  P=0.045 *                (e)                      P=0.470                  P=0.174         |
|POLY 1.5           |                  P=0.054                  (e)                      P=0.484                  P=0.199         |
|POLY 6             |                  P=0.035 *                (e)                      P=0.454                  P=0.145         |
|LOGISTIC REGRESSION|                  P=0.181                  (e)                      P=0.822                  P=0.470         |
|COCH-ARM / FISHERS |                  P=0.069                  (e)                      P=0.505                  P=0.247         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 70
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/49 (4%)                13/50 (26%)              11/50 (22%)              10/49 (20%)     |
|POLY-3 ADJUSTED (b)|                  4.9%                     33.2%                    28.8%                    31.1%           |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                2/11 (18%)               0/7 (0%)        |
|FIRST INCIDENCE    |                  468                      372                      354                      466             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.004 **               P<0.001 **               P=0.003 **               P<0.001 **      |
|POLY 3             |                  P=0.011 *                P<0.001 **               P=0.004 **               P=0.003 **      |
|POLY 1.5           |                  P=0.026 *                P<0.001 **               P=0.005 **               P=0.005 **      |
|POLY 6             |                  P=0.003 **               P<0.001 **               P=0.002 **               P<0.001 **      |
|LOGISTIC REGRESSION|                  P=0.177                  P=0.006 **               P=0.040 *                P=0.040 *       |
|COCH-ARM / FISHERS |                  P=0.083                  P=0.002 **               P=0.008 **               P=0.014 *       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)                1/50 (2%)                2/49 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     2.9%                     7.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      630                      468             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.029 *                (e)                      P=0.462                  P=0.157         |
|POLY 3             |                  P=0.044 *                (e)                      P=0.468                  P=0.172         |
|POLY 1.5           |                  P=0.053                  (e)                      P=0.482                  P=0.197         |
|POLY 6             |                  P=0.034 *                (e)                      P=0.452                  P=0.143         |
|LOGISTIC REGRESSION|                  P=0.093                  (e)                      P=0.522                  P=0.344         |
|COCH-ARM / FISHERS |                  P=0.069                  (e)                      P=0.505                  P=0.247         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 71
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/49 (6%)                5/50 (10%)               3/50 (6%)                1/49 (2%)       |
|POLY-3 ADJUSTED (b)|                  7.3%                     13.5%                    8.6%                     3.5%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  576                      479                      500                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.397N                 P=0.255                  P=0.528                  P=0.543N        |
|POLY 3             |                  P=0.317N                 P=0.300                  P=0.586                  P=0.445N        |
|POLY 1.5           |                  P=0.240N                 P=0.324                  P=0.621                  P=0.383N        |
|POLY 6             |                  P=0.444N                 P=0.274                  P=0.544                  P=0.532N        |
|LOGISTIC REGRESSION|                  P=0.100N                 P=0.475                  P=0.591N                 P=0.186N        |
|COCH-ARM / FISHERS |                  P=0.157N                 P=0.369                  P=0.651N                 P=0.309N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/49 (4%)                4/50 (8%)                3/50 (6%)                4/49 (8%)       |
|POLY-3 ADJUSTED (b)|                  4.9%                     10.8%                    8.6%                     13.4%           |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  644                      372                      404                      466             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.128                  P=0.255                  P=0.399                  P=0.132         |
|POLY 3             |                  P=0.180                  P=0.296                  P=0.434                  P=0.207         |
|POLY 1.5           |                  P=0.237                  P=0.315                  P=0.464                  P=0.258         |
|POLY 6             |                  P=0.119                  P=0.273                  P=0.397                  P=0.151         |
|LOGISTIC REGRESSION|                  P=0.538                  P=0.548                  P=0.638                  P=0.471         |
|COCH-ARM / FISHERS |                  P=0.328                  P=0.349                  P=0.510                  P=0.339         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 72
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/49 (6%)                3/50 (6%)                2/48 (4%)                4/48 (8%)       |
|POLY-3 ADJUSTED (b)|                  7.4%                     8.5%                     6.1%                     13.8%           |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      634                      447                      539             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.124                  P=0.515                  P=0.644N                 P=0.179         |
|POLY 3             |                  P=0.272                  P=0.600                  P=0.593N                 P=0.323         |
|POLY 1.5           |                  P=0.328                  P=0.630                  P=0.557N                 P=0.392         |
|POLY 6             |                  P=0.204                  P=0.561                  P=0.636N                 P=0.241         |
|LOGISTIC REGRESSION|                  P=0.387                  P=0.662                  P=0.426N                 P=0.535         |
|COCH-ARM / FISHERS |                  P=0.404                  P=0.651N                 P=0.510N                 P=0.488         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)                2/48 (4%)                0/48 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     6.1%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---                      645                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.418                  (e)                      P=0.171                  (e)             |
|POLY 3             |                  P=0.418                  (e)                      P=0.197                  (e)             |
|POLY 1.5           |                  P=0.496                  (e)                      P=0.211                  (e)             |
|POLY 6             |                  P=0.310                  (e)                      P=0.181                  (e)             |
|LOGISTIC REGRESSION|                  P=0.499                  (e)                      P=0.189                  (e)             |
|COCH-ARM / FISHERS |                  P=0.589                  (e)                      P=0.242                  (e)             |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 73
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  8/49 (16%)               25/50 (50%)              16/48 (33%)              6/48 (13%)      |
|POLY-3 ADJUSTED (b)|                  19.1%                    56.0%                    40.0%                    19.9%           |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      352                      354                      463             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.475                  P<0.001 **               P=0.018 *                P=0.319         |
|POLY 3             |                  P=0.416N                 P<0.001 **               P=0.029 *                P=0.583         |
|POLY 1.5           |                  P=0.217N                 P<0.001 **               P=0.034 *                P=0.542N        |
|POLY 6             |                  P=0.348                  P<0.001 **               P=0.025 *                P=0.432         |
|LOGISTIC REGRESSION|                  P=0.015N*                P<0.001 **               P=0.144                  P=0.314N        |
|COCH-ARM / FISHERS |                  P=0.075N                 P<0.001 **               P=0.044 *                P=0.403N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  20/50 (40%)              20/49 (41%)              18/49 (37%)              9/50 (18%)      |
|POLY-3 ADJUSTED (b)|                  44.9%                    49.3%                    45.7%                    28.9%           |
|TERMINAL (d)       |                  7/22 (32%)               4/14 (29%)               2/11 (18%)               2/7 (29%)       |
|FIRST INCIDENCE    |                  468                      445                      486                      499             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.527N                 P=0.223                  P=0.243                  P=0.560         |
|POLY 3             |                  P=0.104N                 P=0.424                  P=0.563                  P=0.118N        |
|POLY 1.5           |                  P=0.036N*                P=0.472                  P=0.548N                 P=0.048N*       |
|POLY 6             |                  P=0.296N                 P=0.376                  P=0.500                  P=0.299N        |
|LOGISTIC REGRESSION|                  P=0.011N*                P=0.568                  P=0.423N                 P=0.047N*       |
|COCH-ARM / FISHERS |                  P=0.007N**               P=0.548                  P=0.449N                 P=0.013N*       |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 74
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  6/50 (12%)               2/49 (4%)                9/49 (18%)               4/50 (8%)       |
|POLY-3 ADJUSTED (b)|                  14.5%                    5.7%                     24.6%                    13.7%           |
|TERMINAL (d)       |                  3/22 (14%)               0/14 (0%)                0/11 (0%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  557                      541                      494                      550             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.189                  P=0.250N                 P=0.114                  P=0.361         |
|POLY 3             |                  P=0.349                  P=0.186N                 P=0.200                  P=0.593N        |
|POLY 1.5           |                  P=0.464                  P=0.166N                 P=0.228                  P=0.495N        |
|POLY 6             |                  P=0.215                  P=0.212N                 P=0.175                  P=0.539         |
|LOGISTIC REGRESSION|                  P=0.511N                 P=0.126N                 P=0.314                  P=0.553N        |
|COCH-ARM / FISHERS |                  P=0.512N                 P=0.141N                 P=0.274                  P=0.370N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Artery                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  24/50 (48%)              24/49 (49%)              14/49 (29%)              11/50 (22%)     |
|POLY-3 ADJUSTED (b)|                  53.3%                    61.6%                    39.6%                    34.4%           |
|TERMINAL (d)       |                  9/22 (41%)               9/14 (64%)               4/11 (36%)               2/7 (29%)       |
|FIRST INCIDENCE    |                  468                      506                      575                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.533N                 P=0.151                  P=0.452N                 P=0.513         |
|POLY 3             |                  P=0.022N*                P=0.283                  P=0.153N                 P=0.074N        |
|POLY 1.5           |                  P=0.005N**               P=0.380                  P=0.085N                 P=0.025N*       |
|POLY 6             |                  P=0.110N                 P=0.201                  P=0.272N                 P=0.233N        |
|LOGISTIC REGRESSION|                  P=0.021N*                P=0.379                  P=0.095N                 P=0.029N*       |
|COCH-ARM / FISHERS |                  P<0.001N**               P=0.541                  P=0.037N*                P=0.006N**      |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 75
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Artery                                                                                                                   |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/50 (0%)                3/49 (6%)                2/49 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     8.4%                     5.8%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      506                      486                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.560N                 P=0.094                  P=0.212                  (e)             |
|POLY 3             |                  P=0.592N                 P=0.098                  P=0.203                  (e)             |
|POLY 1.5           |                  P=0.510N                 P=0.104                  P=0.215                  (e)             |
|POLY 6             |                  P=0.460                  P=0.091                  P=0.190                  (e)             |
|LOGISTIC REGRESSION|                  P=0.300N                 P=0.152                  P=0.303                  (e)             |
|COCH-ARM / FISHERS |                  P=0.408N                 P=0.117                  P=0.242                  (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/50 (6%)                4/49 (8%)                7/49 (14%)               7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                  7.4%                     11.6%                    20.5%                    22.0%           |
|TERMINAL (d)       |                  2/22 (9%)                2/14 (14%)               3/11 (27%)               1/7 (14%)       |
|FIRST INCIDENCE    |                  676                      651                      548                      467             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.003 **               P=0.300                  P=0.029 *                P=0.023 *       |
|POLY 3             |                  P=0.037 *                P=0.415                  P=0.093                  P=0.075         |
|POLY 1.5           |                  P=0.059                  P=0.445                  P=0.115                  P=0.105         |
|POLY 6             |                  P=0.018 *                P=0.381                  P=0.073                  P=0.045 *       |
|LOGISTIC REGRESSION|                  P=0.043 *                P=0.347                  P=0.067                  P=0.207         |
|COCH-ARM / FISHERS |                  P=0.101                  P=0.489                  P=0.151                  P=0.159         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 76
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  15/48 (31%)              29/49 (59%)              28/49 (57%)              24/50 (48%)     |
|POLY-3 ADJUSTED (b)|                  34.9%                    64.1%                    62.5%                    60.4%           |
|TERMINAL (d)       |                  1/22 (5%)                2/14 (14%)               1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  557                      352                      354                      443             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P<0.001 **               P=0.003 **               P=0.002 **               P<0.001 **      |
|POLY 3             |                  P=0.028 *                P=0.004 **               P=0.006 **               P=0.013 *       |
|POLY 1.5           |                  P=0.062                  P=0.004 **               P=0.007 **               P=0.027 *       |
|POLY 6             |                  P=0.009 **               P=0.004 **               P=0.005 **               P=0.005 **      |
|LOGISTIC REGRESSION|                  P=0.506                  P=0.015 *                P=0.047 *                P=0.181         |
|COCH-ARM / FISHERS |                  P=0.167                  P=0.005 **               P=0.009 **               P=0.068         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  5/48 (10%)               6/49 (12%)               4/49 (8%)                6/50 (12%)      |
|POLY-3 ADJUSTED (b)|                  12.6%                    16.3%                    11.7%                    19.7%           |
|TERMINAL (d)       |                  2/22 (9%)                1/14 (7%)                1/11 (9%)                1/7 (14%)       |
|FIRST INCIDENCE    |                  572                      479                      481                      489             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.111                  P=0.330                  P=0.516                  P=0.089         |
|POLY 3             |                  P=0.302                  P=0.446                  P=0.594N                 P=0.315         |
|POLY 1.5           |                  P=0.390                  P=0.473                  P=0.548N                 P=0.405         |
|POLY 6             |                  P=0.198                  P=0.417                  P=0.625                  P=0.210         |
|LOGISTIC REGRESSION|                  P=0.533                  P=0.561                  P=0.488N                 P=0.438         |
|COCH-ARM / FISHERS |                  P=0.511                  P=0.515                  P=0.487N                 P=0.529         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 77
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Ectopic Parathyroid Gland                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  3/48 (6%)                5/49 (10%)               1/49 (2%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  7.7%                     13.8%                    3.0%                     3.5%            |
|TERMINAL (d)       |                  2/22 (9%)                0/14 (0%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  717                      479                      700                      486             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.353N                 P=0.225                  P=0.540N                 P=0.643N        |
|POLY 3             |                  P=0.193N                 P=0.314                  P=0.367N                 P=0.419N        |
|POLY 1.5           |                  P=0.149N                 P=0.334                  P=0.336N                 P=0.360N        |
|POLY 6             |                  P=0.273N                 P=0.296                  P=0.407N                 P=0.506N        |
|LOGISTIC REGRESSION|                  P=0.134N                 P=0.344                  P=0.488N                 P=0.424N        |
|COCH-ARM / FISHERS |                  P=0.106N                 P=0.369                  P=0.301N                 P=0.293N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  8/48 (17%)               6/49 (12%)               8/49 (16%)               14/50 (28%)     |
|POLY-3 ADJUSTED (b)|                  19.1%                    17.0%                    21.5%                    38.1%           |
|TERMINAL (d)       |                  1/22 (5%)                2/14 (14%)               0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  283                      593                      404                      94              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.003 **               P=0.584N                 P=0.419                  P=0.015 *       |
|POLY 3             |                  P=0.021 *                P=0.524N                 P=0.506                  P=0.048 *       |
|POLY 1.5           |                  P=0.031 *                P=0.462N                 P=0.555                  P=0.078         |
|POLY 6             |                  P=0.011 *                P=0.597N                 P=0.444                  P=0.024 *       |
|LOGISTIC REGRESSION|                  P=0.237                  P=0.321N                 P=0.259N                 P=0.464N        |
|COCH-ARM / FISHERS |                  P=0.049 *                P=0.371N                 P=0.590N                 P=0.135         |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 78
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/48 (0%)                0/49 (0%)                0/49 (0%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%                     0.0%                     7.1%            |
|TERMINAL (d)       |                  0/22 (0%)                0/14 (0%)                0/11 (0%)                2/7 (29%)       |
|FIRST INCIDENCE    |                  ---                      ---                      ---                      722 (T)         |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.006 **               (e)                      (e)                      P=0.043 *       |
|POLY 3             |                  P=0.037 *                (e)                      (e)                      P=0.173         |
|POLY 1.5           |                  P=0.041 *                (e)                      (e)                      P=0.203         |
|POLY 6             |                  P=0.037 *                (e)                      (e)                      P=0.138         |
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      P=0.043 *       |
|COCH-ARM / FISHERS |                  P=0.049 *                (e)                      (e)                      P=0.258         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicle                                                                                                          |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  2/49 (4%)                4/50 (8%)                5/48 (10%)               1/49 (2%)       |
|POLY-3 ADJUSTED (b)|                  5.1%                     11.0%                    15.2%                    3.6%            |
|TERMINAL (d)       |                  2/22 (9%)                0/14 (0%)                3/11 (27%)               0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  506                      700                      658             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.350                  P=0.214                  P=0.044 *                P=0.658         |
|POLY 3             |                  P=0.551                  P=0.301                  P=0.148                  P=0.617N        |
|POLY 1.5           |                  P=0.477N                 P=0.318                  P=0.172                  P=0.566N        |
|POLY 6             |                  P=0.384                  P=0.283                  P=0.124                  P=0.681N        |
|LOGISTIC REGRESSION|                  P=0.547                  P=0.311                  P=0.071                  P=0.718         |
|COCH-ARM / FISHERS |                  P=0.348N                 P=0.349                  P=0.209                  P=0.500N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 79
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  0/49 (0%)                2/50 (4%)                1/48 (2%)                0/49 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     5.6%                     3.0%                     0.0%            |
|TERMINAL (d)       |                  0/22 (0%)                1/14 (7%)                0/11 (0%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  ---                      593                      628                      ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.664N                 P=0.178                  P=0.469                  (e)             |
|POLY 3             |                  P=0.590N                 P=0.215                  P=0.467                  (e)             |
|POLY 1.5           |                  P=0.535N                 P=0.226                  P=0.479                  (e)             |
|POLY 6             |                  P=0.553                  P=0.204                  P=0.453                  (e)             |
|LOGISTIC REGRESSION|                  P=0.518N                 P=0.226                  P=0.506                  (e)             |
|COCH-ARM / FISHERS |                  P=0.463N                 P=0.253                  P=0.495                  (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth: Peridontal Tissue                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/2 (50%)                1/2 (50%)                4/4 (100%)               1/3 (33%)       |
|POLY-3 ADJUSTED (b)|                  50.0%                    50.0%                    100.0%                   37.7%           |
|TERMINAL (d)       |                  1/2 (50%)                1/2 (50%)                1/1 (100%)               0/1 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  722 (T)                  354                      709             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.188                  P=0.807                  P=0.052                  P=0.561         |
|POLY 3             |                  P=0.598N                 P=0.760                  P=0.342                  P=0.707N        |
|POLY 1.5           |                  P=0.553N                 P=0.760                  P=0.342                  P=0.690N        |
|POLY 6             |                  P=0.652                  P=0.760                  P=0.342                  P=0.733N        |
|LOGISTIC REGRESSION|                  P=0.447N                 P=0.807                  (e)                      P=0.851         |
|COCH-ARM / FISHERS |                  P=0.500N                 P=0.833N                 P=0.333                  P=0.700N        |
|=================================================================================================================================|
       Date:  09/29/97                           EXPERIMENT: 55301 TEST: 06                                            Page 80
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(WISTAR OUTBRED)  -                      PYRIDINE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth: Peridontal Tissue                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/2 (50%)                0/2 (0%)                 0/4 (0%)                 2/3 (67%)       |
|POLY-3 ADJUSTED (b)|                  50.0%                    0.0%                     0.0%                     67.9%           |
|TERMINAL (d)       |                  1/2 (50%)                0/2 (0%)                 0/1 (0%)                 1/1 (100%)      |
|FIRST INCIDENCE    |                  722 (T)                  ---                      ---                      627             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.087                  P=0.500N                 P=0.638N                 P=0.216         |
|POLY 3             |                  P=0.298                  P=0.500N                 P=0.429N                 P=0.666         |
|POLY 1.5           |                  P=0.300                  P=0.500N                 P=0.396N                 P=0.668         |
|POLY 6             |                  P=0.293                  P=0.500N                 P=0.466N                 P=0.662         |
|LOGISTIC REGRESSION|                  P=0.292                  (e)                      (e)                      P=0.851N        |
|COCH-ARM / FISHERS |                  P=0.316                  P=0.500N                 P=0.333N                 P=0.700         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |                  0 PPM                    100 PPM      |           200 PPM                  400 PPM         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder: Transitional Epithelium                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                  1/47 (2%)                3/49 (6%)                1/47 (2%)                0/44 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.6%                     8.5%                     3.2%                     0.0%            |
|TERMINAL (d)       |                  1/22 (5%)                0/14 (0%)                1/11 (9%)                0/7 (0%)        |
|FIRST INCIDENCE    |                  722 (T)                  352                      722 (T)                  ---             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                  P=0.438N                 P=0.206                  P=0.600                  P=0.727N        |
|POLY 3             |                  P=0.337N                 P=0.271                  P=0.714                  P=0.584N        |
|POLY 1.5           |                  P=0.281N                 P=0.290                  P=0.733                  P=0.555N        |
|POLY 6             |                  P=0.425N                 P=0.249                  P=0.690                  P=0.621N        |
|LOGISTIC REGRESSION|                  P=0.251N                 P=0.358                  P=0.600                  (e)             |
|COCH-ARM / FISHERS |                  P=0.216N                 P=0.324                  P=0.753N                 P=0.516N        |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).