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TDMS Study 55312-03 Pathology Tables

NTP  EXP/TEST: 55312-03                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 1
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 08/21/97
ROUTE: SKIN APPLICATION                                                                                           TIME: 14:53:21

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  55312B

       CONTRACT NUMBER:  N01-ES-15314

       CAS NUMBER:  68603-42-9

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 55312-03                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 2
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 08/21/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:53:21
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 2                      ROOM/AREA:    201         FIRST DOSE: 02/02/93
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

153         153  365 02/01/94   449 04/26/94   4/26  Irritation Site of Applic

183         183  505 06/21/94   701 01/03/95   8/26  Irritation Site of Applic

195         195  365 02/01/94   533 07/19/94   7/21  Irritation Site of Applic

200         200  477 05/24/94   533 07/19/94   3/26  Irritation Site of Applic

NTP  EXP/TEST: 55312-03                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 3
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 08/21/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:53:21
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:    201         FIRST DOSE: 02/02/93
            SEX: FEMALE                               TRT: 50 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

213         213  533 07/19/94   533 07/19/94   1/20  Irritation Site of Applic

NTP  EXP/TEST: 55312-03                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 4
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 08/21/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:53:21
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:    201         FIRST DOSE: 02/02/93
            SEX: FEMALE                               TRT: 100     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

252         252  365 02/01/94   449 04/26/94   2/26  Irritation Site of Applic

254         254  169 07/20/93   169 07/20/93   1/26  Irritation Site of Applic

257         257  113 05/25/93   113 05/25/93   1/23  Irritation Site of Applic

259         259  113 05/25/93   113 05/25/93   1/26  Irritation Site of Applic

261         261  449 04/26/94   505 06/21/94   2/26  Irritation Site of Applic

264         264  393 03/01/94   421 03/29/94   2/17  Irritation Site of Applic

265         265  421 03/29/94   421 03/29/94   1/24  Irritation Site of Applic

267         267  113 05/25/93   113 05/25/93   1/14  Irritation Site of Applic

269         269  141 06/22/93   141 06/22/93   1/26  Irritation Site of Applic

271         271  365 02/01/94   701 01/03/95   9/26  Irritation Site of Applic

273         273   57 03/30/93    57 03/30/93   1/26  Irritation Site of Applic

276         276  365 02/01/94   533 07/19/94   3/20  Irritation Site of Applic

278         278  113 05/25/93   113 05/25/93   1/26  Irritation Site of Applic

281         281   29 03/02/93   701 01/03/95  14/26  Irritation Site of Applic

284         284  141 06/22/93   141 06/22/93   1/24  Irritation Site of Applic

285         285  617 10/11/94   645 11/08/94   2/26  Papilloma Site of Applic 1
                 673 12/06/94   701 01/03/95   2/26  Irritation Site of Applic

286         286  365 02/01/94   449 04/26/94   4/23  Irritation Site of Applic

289         289  169 07/20/93   365 02/01/94   2/26  Irritation Site of Applic

293         293  113 05/25/93   197 08/17/93   3/10  Irritation Site of Applic

294         294  365 02/01/94   449 04/26/94   2/20  Irritation Site of Applic

295         295   57 03/30/93   449 04/26/94   3/26  Irritation Site of Applic

297         297  505 06/21/94   505 06/21/94   1/26  Irritation Site of Applic

299         299  113 05/25/93   113 05/25/93   1/26  Irritation Site of Applic

300         300  365 02/01/94   365 02/01/94   1/26  Irritation Site of Applic

NTP  EXP/TEST: 55312-03                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 5
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 08/21/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:53:21
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 1                      ROOM/AREA:    201         FIRST DOSE: 02/01/93
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 55312-03                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 6
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 08/21/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:53:21
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 3                      ROOM/AREA:    201         FIRST DOSE: 02/01/93
            SEX: MALE                                 TRT: 50 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

77           77  393 02/28/94   505 06/20/94   5/19  Papilloma Site of Applic 1

90           90  645 11/07/94   673 12/05/94   2/25  Papilloma Site of Applic 1

NTP  EXP/TEST: 55312-03                    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                             PAGE: 7
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 08/21/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:53:21
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:    201         FIRST DOSE: 02/01/93
            SEX: MALE                                 TRT: 100     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

120         120   57 03/29/93    57 03/29/93   1/26  Irritation Site of Applic

138         138  393 02/28/94   645 11/07/94  10/24  Papilloma Site of Applic 1



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