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TDMS Study 55312-03 Pathology Tables

NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99
Route: SKIN APPLICATION                                                                                           Time: 08:08:18

                                                      2 YEAR CHRONIC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  68603-42-9

       Lock Date:  09/06/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     15           11           18                                                  
    Moribund Sacrifice                                 7           15           10                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           24           21                                                  
    Moribund Sacrifice                                                           1                                                  

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (50)         (50)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                          (4)          (5)          (2)                                                 
   Oral Mucosa                                        (1)          (1)          (3)                                                 
      Gingival, Squamous Cell Carcinoma                                          1 (33%)                                            
   Pancreas                                           (50)         (50)         (50)                                                
   Salivary Glands                                    (50)         (50)         (49)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Squamous Cell Papilloma, Multiple                             1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Adenoma                                                       2 (4%)                                                          
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Pheochromocytoma Benign                                       4 (8%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                    2 (4%)                                             
   Parathyroid Gland                                  (42)         (46)         (45)                                                
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (49)         (50)                                                
NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                          27 (54%)     26 (53%)     24 (48%)                                            
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  4 (8%)       3 (6%)       6 (12%)                                            
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       2 (4%)                                             
      Follicular Cell, Adenoma                         2 (4%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)                                                
      Adenoma                                          7 (14%)      5 (10%)      4 (8%)                                             
      Carcinoma                                        1 (2%)       6 (12%)      2 (4%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
      Bilateral, Carcinoma                             1 (2%)       2 (4%)       2 (4%)                                             
   Ovary                                              (50)         (50)         (50)                                                
      Granulosa-Theca Tumor Malignant                  1 (2%)                                                                       
      Granulosa-Theca Tumor Benign                                               1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)                                                
      Deciduoma Benign                                                           1 (2%)                                             
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp Stromal                                    6 (12%)      6 (12%)      5 (10%)                                            
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (41)         (36)         (36)                                                
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                                                       
   Lymph Node, Mandibular                             (50)         (48)         (47)                                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
   Thymus                                             (47)         (50)         (49)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        2 (4%)       1 (2%)       2 (4%)                                             
      Carcinoma, Multiple                                           1 (2%)                                                          
      Fibroadenoma                                    17 (35%)     14 (28%)      3 (6%)                                             
      Fibroadenoma, Multiple                           1 (2%)       2 (4%)                                                          
   Skin                                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma, Multiple                                          1 (2%)                                             
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Adenoma                                                  1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Pinna, Melanoma                                                                                          
          Malignant                                    1 (2%)                                                                       
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibrosarcoma                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Femur, Osteosarcoma                              1 (2%)                                                                       
   Skeletal Muscle                                    (3)          (1)                                                              
      Histiocytic Sarcoma                              1 (33%)                                                                      
      Osteosarcoma, Metastatic, Bone                   1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                       1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Renal Tubule, Carcinoma                                       2 (4%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Papilloma                                                     1 (2%)                                                          
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            10 (20%)      9 (18%)      4 (8%)                                             
      Lymphoma Malignant                                            2 (4%)                                                          
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          43          37                                                   
     Total Primary Neoplasms                           89          93          65                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          39          34                                                   
     Total Benign Neoplasms                            69          66          50                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          20          15                                                   
     Total Malignant Neoplasms                         20          27          15                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          3                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28           27           25                                                  
    Natural Death                                     13           11           14                                                  
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8           12           11                                                  

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
   Intestine Large, Colon                             (50)         (50)         (50)                                                
      Polyp Adenomatous                                             1 (2%)       1 (2%)                                             
   Intestine Small, Ileum                             (50)         (50)         (50)                                                
   Liver                                              (50)         (50)         (50)                                                
   Mesentery                                          (8)          (7)          (6)                                                 
      Fat, Fibrosarcoma                                             1 (14%)                                                         
   Oral Mucosa                                        (1)          (2)          (2)                                                 
      Gingival, Squamous Cell Carcinoma                                          1 (50%)                                            
      Pharyngeal, Squamous Cell Papilloma              1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)                                                
      Acinus, Adenoma                                  1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma                          3 (6%)                    1 (2%)                                             
      Squamous Cell Papilloma, Multiple                             1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Ganglioneuroma                                                1 (2%)                                                          
      Pheochromocytoma Malignant                                    1 (2%)                                                          
NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          6 (12%)      4 (8%)       5 (10%)                                            
      Bilateral, Pheochromocytoma Benign                            1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          3 (6%)       4 (8%)       3 (6%)                                             
   Pituitary Gland                                    (50)         (50)         (49)                                                
      Sarcoma, Metastatic, Brain                       1 (2%)                                                                       
      Pars Distalis, Adenoma                          37 (74%)     39 (78%)     36 (73%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  3 (6%)       4 (8%)       4 (8%)                                             
      C-Cell, Carcinoma                                                          1 (2%)                                             
      Follicular Cell, Adenoma                                      3 (6%)       1 (2%)                                             
      Follicular Cell, Carcinoma                       2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
   Preputial Gland                                    (50)         (50)         (50)                                                
      Adenoma                                                       2 (4%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)       2 (4%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
   Prostate                                           (50)         (50)         (50)                                                
      Carcinoma                                        2 (4%)                                                                       
   Seminal Vesicle                                    (50)         (50)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           11 (22%)      9 (18%)     12 (24%)                                            
      Interstitial Cell, Adenoma                      12 (24%)     11 (22%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (35)         (30)         (37)                                                
      Mediastinal, Fibrosarcoma, Metastatic, Skin                   1 (3%)                                                          
   Lymph Node, Mandibular                             (50)         (50)         (50)                                                
   Lymph Node, Mesenteric                             (49)         (50)         (50)                                                
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
   Thymus                                             (47)         (45)         (48)                                                
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (2%)       1 (2%)                                             
      Fibroadenoma                                     2 (4%)       1 (2%)       1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                  2 (4%)       4 (8%)                                                          
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
      Trichoepithelioma                                                          1 (2%)                                             
      Pinna, Squamous Cell Papilloma                                1 (2%)                                                          
      Sebaceous Gland, Carcinoma                                    1 (2%)                                                          
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Adenoma                                     1 (2%)                                                                       
      Skin, Site of Application, Basal Cell Adenoma                 1 (2%)                                                          
      Skin, Site of Application, Basal Cell                                                                                         
          Carcinoma                                    1 (2%)                                                                       
      Skin, Site of Application, Keratoacanthoma       1 (2%)       2 (4%)                                                          
      Subcutaneous Tissue, Fibroma                     3 (6%)       3 (6%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibrosarcoma                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Cranial Nerve, Schwannoma Malignant              1 (2%)                                                                       
      Meninges, Sarcoma                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (2)                                                              
      Carcinoma                                        1 (100%)     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Lipoma                                                        1 (2%)                                                          
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)       4 (8%)                                                          
      Renal Tubule, Adenoma, Multiple                               1 (2%)                                                          
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Granulocytic                                         1 (2%)                                                          
      Leukemia Mononuclear                            16 (32%)     10 (20%)     12 (24%)                                            
      Mesothelioma Malignant                           2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  10                                                               
NTP Experiment-Test: 55312-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          48                                                   
     Total Primary Neoplasms                          117         124          98                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          49          46                                                   
     Total Benign Neoplasms                            90         100          75                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          20          21                                                   
     Total Malignant Neoplasms                         27          24          23                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1                                                   
     Total Metastatic Neoplasm                          1           1           3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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