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TDMS Study 55312-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                         COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                      DATE: 02/24/99       
EXPERIMENT: 55312 TEST: 03                                                                                     TIME: 13:45:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55312B       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 68603-42-9      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                         2 YEAR CHONIC RATS                                                         
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                         COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                      DATE: 02/24/99

EXPERIMENT: 55312 TEST: 03                                                                                     TIME: 13:45:17
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55312B
PATHOLOGIST: TOFT, J.                                                                                          CAS: 68603-42-9

Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Brain
                                                 Clitoral/Preputial Gland
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Prostate
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                         COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                      DATE: 02/24/99     
EXPERIMENT: 55312 TEST: 03                                                                                     TIME: 13:45:17     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: N01-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55312B     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 68603-42-9    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Skin
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom
                                       Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
                                       Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Medulla                        Pheochromocytoma Benign
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland               Carcinoma
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
All Organs                             Benign Tumors
                                       Malignant and Benign Tumors
===============================================================
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 1

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.9%             0.0%          |  0.0%             5.3%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        2/24 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              611              ---           |  ---              728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.711N         P=0.541          (e)           |  P=0.616          P=0.204          (e)             |
|POLY 3             |        P=0.709N         P=0.529          (e)           |  P=0.605          P=0.210          (e)             |
|POLY 1.5           |        P=0.717N         P=0.518          (e)           |  P=0.625          P=0.218          (e)             |
|POLY 6             |        P=0.698N         P=0.546          (e)           |  P=0.592          P=0.205          (e)             |
|LOGISTIC REGRESSION|        P=0.729          P=0.498          (e)           |  (e)              P=0.204          (e)             |
|COCH-ARM / FISHERS |        P=0.731          P=0.500          (e)           |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       5/50 (10%)       6/50 (12%)    |  0/50 (0%)        4/50 (8%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        18.7%            14.0%            17.1%         |  0.0%             10.6%            0.0%            |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        4/11 (36%)    |  0/28 (0%)        3/24 (13%)       0/22 (0%)       |
|FIRST INCIDENCE    |        603              586              607           |  ---              677              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.389N         P=0.341N         P=0.427N      |  P=0.542          P=0.048 *        (e)             |
|POLY 3             |        P=0.511N         P=0.422N         P=0.561N      |  P=0.516          P=0.046 *        (e)             |
|POLY 1.5           |        P=0.527N         P=0.449N         P=0.580N      |  P=0.550          P=0.050          (e)             |
|POLY 6             |        P=0.498N         P=0.392N         P=0.545N      |  P=0.494          P=0.044 *        (e)             |
|LOGISTIC REGRESSION|        P=0.467N         P=0.422N         P=0.513N      |  P=0.550          P=0.045 *        (e)             |
|COCH-ARM / FISHERS |        P=0.563          P=0.500N         P=0.620N      |  P=0.622          P=0.059          (e)             |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 2

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       6/50 (12%)       6/50 (12%)    |  0/50 (0%)        4/50 (8%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        18.7%            16.8%            17.1%         |  0.0%             10.6%            0.0%            |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        4/11 (36%)    |  0/28 (0%)        3/24 (13%)       0/22 (0%)       |
|FIRST INCIDENCE    |        603              586              607           |  ---              677              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.381N         P=0.433N         P=0.427N      |  P=0.542          P=0.048 *        (e)             |
|POLY 3             |        P=0.503N         P=0.545N         P=0.561N      |  P=0.516          P=0.046 *        (e)             |
|POLY 1.5           |        P=0.521N         P=0.571N         P=0.580N      |  P=0.550          P=0.050          (e)             |
|POLY 6             |        P=0.488N         P=0.517N         P=0.545N      |  P=0.494          P=0.044 *        (e)             |
|LOGISTIC REGRESSION|        P=0.454N         P=0.528N         P=0.513N      |  P=0.550          P=0.045 *        (e)             |
|COCH-ARM / FISHERS |        P=0.561          P=0.620N         P=0.620N      |  P=0.622          P=0.059          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        1/50 (2%)     |  8/49 (16%)       5/50 (10%)       4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        3.3%             5.7%             2.9%          |  19.1%            13.1%            11.1%           |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        0/11 (0%)     |  6/28 (21%)       4/24 (17%)       1/22 (5%)       |
|FIRST INCIDENCE    |        729 (T)          611              640           |  680              578              669             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.542N         P=0.618          P=0.694N      |  P=0.256N         P=0.385N         P=0.318N        |
|POLY 3             |        P=0.578N         P=0.551          P=0.731N      |  P=0.200N         P=0.338N         P=0.259N        |
|POLY 1.5           |        P=0.595N         P=0.531          P=0.743N      |  P=0.176N         P=0.317N         P=0.229N        |
|POLY 6             |        P=0.555N         P=0.580          P=0.713N      |  P=0.216N         P=0.350N         P=0.278N        |
|LOGISTIC REGRESSION|        P=0.569N         P=0.584          P=0.718N      |  P=0.222N         P=0.360N         P=0.287N        |
|COCH-ARM / FISHERS |        P=0.622          P=0.500          P=0.753N      |  P=0.127N         P=0.264N         P=0.168N        |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 3

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)     |  2/49 (4%)        8/50 (16%)       4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.9%             5.7%          |  4.8%             21.0%            11.0%           |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  1/28 (4%)        7/24 (29%)       2/22 (9%)       |
|FIRST INCIDENCE    |        ---              620              552           |  669              578              536             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.187          P=0.539          P=0.300       |  P=0.185          P=0.026 *        P=0.243         |
|POLY 3             |        P=0.173          P=0.529          P=0.270       |  P=0.197          P=0.029 *        P=0.272         |
|POLY 1.5           |        P=0.160          P=0.518          P=0.257       |  P=0.229          P=0.034 *        P=0.293         |
|POLY 6             |        P=0.192          P=0.545          P=0.291       |  P=0.179          P=0.026 *        P=0.260         |
|LOGISTIC REGRESSION|        P=0.139          P=0.504          P=0.237       |  P=0.218          P=0.029 *        P=0.291         |
|COCH-ARM / FISHERS |        P=0.142          P=0.500          P=0.247       |  P=0.314          P=0.049 *        P=0.349         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        3/50 (6%)     |  9/49 (18%)       13/50 (26%)      8/50 (16%)      |
|POLY-3 ADJUSTED (b)|        3.3%             8.5%             8.5%          |  21.3%            33.6%            21.8%           |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        0/11 (0%)     |  6/28 (21%)       11/24 (46%)      3/22 (14%)      |
|FIRST INCIDENCE    |        729 (T)          611              552           |  669              578              536             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.334          P=0.419          P=0.411       |  P=0.411          P=0.124          P=0.501         |
|POLY 3             |        P=0.307          P=0.362          P=0.362       |  P=0.487          P=0.158          P=0.587         |
|POLY 1.5           |        P=0.278          P=0.339          P=0.338       |  P=0.541          P=0.182          P=0.587N        |
|POLY 6             |        P=0.352          P=0.398          P=0.399       |  P=0.457          P=0.143          P=0.566         |
|LOGISTIC REGRESSION|        P=0.269          P=0.369          P=0.341       |  P=0.467          P=0.138          P=0.554         |
|COCH-ARM / FISHERS |        P=0.238          P=0.309          P=0.309       |  P=0.430N         P=0.251          P=0.482N        |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 4

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        4/50 (8%)        3/50 (6%)     |  1/50 (2%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        9.7%             11.3%            8.8%          |  2.3%             0.0%             5.6%            |
|TERMINAL (d)       |        0/8 (0%)         2/12 (17%)       3/11 (27%)    |  1/28 (4%)        0/24 (0%)        2/22 (9%)       |
|FIRST INCIDENCE    |        607              523              729 (T)       |  728 (T)          ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.460N         P=0.639N         P=0.543N      |  P=0.297          P=0.531N         P=0.415         |
|POLY 3             |        P=0.530N         P=0.571          P=0.619N      |  P=0.346          P=0.525N         P=0.437         |
|POLY 1.5           |        P=0.546N         P=0.545          P=0.634N      |  P=0.351          P=0.518N         P=0.456         |
|POLY 6             |        P=0.514N         P=0.603          P=0.604N      |  P=0.343          P=0.529N         P=0.425         |
|LOGISTIC REGRESSION|        P=0.481N         P=0.583          P=0.559N      |  P=0.297          (e)              P=0.415         |
|COCH-ARM / FISHERS |        P=0.579          P=0.500          P=0.661N      |  P=0.360          P=0.500N         P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        5/50 (10%)       0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.3%             14.4%            0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         2/12 (17%)       0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        642              695              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.299N         P=0.216          P=0.445N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.322N         P=0.129          P=0.477N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.350N         P=0.119          P=0.486N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.287N         P=0.144          P=0.466N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.297N         P=0.175          P=0.483N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.399N         P=0.102          P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 5

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.9%             0.0%          |  0.0%             5.3%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              656              ---           |  ---              719              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.685N         P=0.569          (e)           |  P=0.613          P=0.208          (e)             |
|POLY 3             |        P=0.709N         P=0.528          (e)           |  P=0.605          P=0.210          (e)             |
|POLY 1.5           |        P=0.717N         P=0.517          (e)           |  P=0.625          P=0.218          (e)             |
|POLY 6             |        P=0.698N         P=0.544          (e)           |  P=0.592          P=0.206          (e)             |
|LOGISTIC REGRESSION|        P=0.719N         P=0.526          (e)           |  P=0.618          P=0.204          (e)             |
|COCH-ARM / FISHERS |        P=0.731          P=0.500          (e)           |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        6/50 (12%)       0/50 (0%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.3%             17.1%            0.0%          |  0.0%             5.3%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         2/12 (17%)       0/11 (0%)     |  0/28 (0%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        642              656              ---           |  ---              719              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.292N         P=0.147          P=0.445N      |  P=0.613          P=0.208          (e)             |
|POLY 3             |        P=0.319N         P=0.076          P=0.477N      |  P=0.605          P=0.210          (e)             |
|POLY 1.5           |        P=0.351N         P=0.068          P=0.486N      |  P=0.625          P=0.218          (e)             |
|POLY 6             |        P=0.279N         P=0.088          P=0.466N      |  P=0.592          P=0.206          (e)             |
|LOGISTIC REGRESSION|        P=0.304N         P=0.104          P=0.483N      |  P=0.618          P=0.204          (e)             |
|COCH-ARM / FISHERS |        P=0.406N         P=0.056          P=0.500N      |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 6

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)     |  2/50 (4%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.9%             2.9%          |  4.7%             5.3%             5.6%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        1/11 (9%)     |  2/28 (7%)        2/24 (8%)        2/22 (9%)       |
|FIRST INCIDENCE    |        ---              713              729 (T)       |  728 (T)          728 (T)          728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.365          P=0.575          P=0.564       |  P=0.503          P=0.640          P=0.607         |
|POLY 3             |        P=0.376          P=0.527          P=0.525       |  P=0.535          P=0.649          P=0.627         |
|POLY 1.5           |        P=0.359          P=0.517          P=0.515       |  P=0.555          P=0.662          P=0.648         |
|POLY 6             |        P=0.401          P=0.542          P=0.539       |  P=0.522          P=0.641          P=0.614         |
|LOGISTIC REGRESSION|        P=0.379          P=0.569          P=0.564       |  P=0.503          P=0.640          P=0.607         |
|COCH-ARM / FISHERS |        P=0.331          P=0.500          P=0.500       |  P=0.601          P=0.691N         P=0.691N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)     |  3/50 (6%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        3.3%             2.9%             2.9%          |  7.0%             5.3%             5.6%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        1/11 (9%)     |  3/28 (11%)       2/24 (8%)        2/22 (9%)       |
|FIRST INCIDENCE    |        563              713              729 (T)       |  728 (T)          728 (T)          728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.599N         P=0.703N         P=0.712N      |  P=0.513N         P=0.571N         P=0.611N        |
|POLY 3             |        P=0.619N         P=0.735N         P=0.738N      |  P=0.490N         P=0.557N         P=0.582N        |
|POLY 1.5           |        P=0.626N         P=0.744N         P=0.746N      |  P=0.464N         P=0.541N         P=0.557N        |
|POLY 6             |        P=0.612N         P=0.722N         P=0.727N      |  P=0.507N         P=0.567N         P=0.598N        |
|LOGISTIC REGRESSION|        P=0.602N         P=0.748N         P=0.743N      |  P=0.513N         P=0.571N         P=0.611N        |
|COCH-ARM / FISHERS |        P=0.640          P=0.753N         P=0.753N      |  P=0.406N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 7

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        1/50 (2%)     |  18/50 (36%)      16/50 (32%)      3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        6.6%             2.9%             2.9%          |  41.4%            41.0%            8.4%            |
|TERMINAL (d)       |        2/8 (25%)        0/12 (0%)        0/11 (0%)     |  13/28 (46%)      9/24 (38%)       2/22 (9%)       |
|FIRST INCIDENCE    |        729 (T)          670              621           |  618              578              669             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.279N         P=0.362N         P=0.395N      |  P=0.005N**       P=0.529          P=0.002N**      |
|POLY 3             |        P=0.352N         P=0.451N         P=0.452N      |  P<0.001N**       P=0.577N         P<0.001N**      |
|POLY 1.5           |        P=0.362N         P=0.470N         P=0.471N      |  P<0.001N**       P=0.533N         P<0.001N**      |
|POLY 6             |        P=0.340N         P=0.422N         P=0.424N      |  P=0.002N**       P=0.591          P<0.001N**      |
|LOGISTIC REGRESSION|        P=0.313N         P=0.387N         P=0.419N      |  P=0.002N**       P=0.546          P<0.001N**      |
|COCH-ARM / FISHERS |        P=0.378N         P=0.500N         P=0.500N      |  P<0.001N**       P=0.417N         P<0.001N**      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        1/50 (2%)        1/50 (2%)     |  18/50 (36%)      16/50 (32%)      3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        9.8%             2.9%             2.9%          |  41.4%            41.0%            8.4%            |
|TERMINAL (d)       |        2/8 (25%)        0/12 (0%)        0/11 (0%)     |  13/28 (46%)      9/24 (38%)       2/22 (9%)       |
|FIRST INCIDENCE    |        563              670              621           |  618              578              669             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.134N         P=0.197N         P=0.221N      |  P=0.005N**       P=0.529          P=0.002N**      |
|POLY 3             |        P=0.182N         P=0.260N         P=0.261N      |  P<0.001N**       P=0.577N         P<0.001N**      |
|POLY 1.5           |        P=0.189N         P=0.276N         P=0.278N      |  P<0.001N**       P=0.533N         P<0.001N**      |
|POLY 6             |        P=0.173N         P=0.237N         P=0.238N      |  P=0.002N**       P=0.591          P<0.001N**      |
|LOGISTIC REGRESSION|        P=0.165N         P=0.240N         P=0.256N      |  P=0.002N**       P=0.546          P<0.001N**      |
|COCH-ARM / FISHERS |        P=0.202N         P=0.309N         P=0.309N      |  P<0.001N**       P=0.417N         P<0.001N**      |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 8

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        2/50 (4%)     |  20/50 (40%)      16/50 (32%)      5/50 (10%)      |
|POLY-3 ADJUSTED (b)|        9.8%             5.7%             5.8%          |  46.0%            41.0%            14.0%           |
|TERMINAL (d)       |        2/8 (25%)        0/12 (0%)        1/11 (9%)     |  15/28 (54%)      9/24 (38%)       4/22 (18%)      |
|FIRST INCIDENCE    |        563              670              621           |  618              578              669             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.300N         P=0.349N         P=0.379N      |  P=0.007N**       P=0.483N         P=0.004N**      |
|POLY 3             |        P=0.367N         P=0.442N         P=0.445N      |  P=0.002N**       P=0.407N         P=0.002N**      |
|POLY 1.5           |        P=0.382N         P=0.464N         P=0.466N      |  P<0.001N**       P=0.368N         P<0.001N**      |
|POLY 6             |        P=0.348N         P=0.411N         P=0.415N      |  P=0.003N**       P=0.420N         P=0.002N**      |
|LOGISTIC REGRESSION|        P=0.328N         P=0.405N         P=0.419N      |  P=0.003N**       P=0.470N         P=0.003N**      |
|COCH-ARM / FISHERS |        P=0.406N         P=0.500N         P=0.500N      |  P<0.001N**       P=0.266N         P<0.001N**      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        37/50 (74%)      39/50 (78%)      36/49 (73%)   |  27/50 (54%)      26/49 (53%)      24/50 (48%)     |
|POLY-3 ADJUSTED (b)|        80.8%            83.5%            77.6%         |  58.3%            62.2%            60.0%           |
|TERMINAL (d)       |        5/8 (63%)        8/12 (67%)       6/11 (55%)    |  15/28 (54%)      12/24 (50%)      11/22 (50%)     |
|FIRST INCIDENCE    |        334              444              329           |  522              382              479             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.164N         P=0.243N         P=0.187N      |  P=0.340          P=0.363          P=0.379         |
|POLY 3             |        P=0.392N         P=0.472          P=0.451N      |  P=0.471          P=0.437          P=0.524         |
|POLY 1.5           |        P=0.422N         P=0.460          P=0.475N      |  P=0.532N         P=0.480          P=0.564N        |
|POLY 6             |        P=0.370N         P=0.500          P=0.433N      |  P=0.431          P=0.427          P=0.485         |
|LOGISTIC REGRESSION|        P=0.510          P=0.395          P=0.528       |  P=0.537          P=0.480          P=0.573         |
|COCH-ARM / FISHERS |        P=0.523N         P=0.408          P=0.567N      |  P=0.308N         P=0.543N         P=0.345N        |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 9

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |                                                    |
|POLY-3 ADJUSTED (b)|        6.6%             0.0%             0.0%          |                                                    |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |                                                    |
|FIRST INCIDENCE    |        680              ---              ---           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.066N         P=0.161N         P=0.188N      |                                                    |
|POLY 3             |        P=0.093N         P=0.209N         P=0.211N      |                                                    |
|POLY 1.5           |        P=0.094N         P=0.219N         P=0.221N      |                                                    |
|POLY 6             |        P=0.094N         P=0.196N         P=0.198N      |                                                    |
|LOGISTIC REGRESSION|        P=0.070N         P=0.182N         P=0.186N      |                                                    |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.4%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        392              ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.077N         P=0.192N         P=0.203N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.093N         P=0.212N         P=0.214N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.094N         P=0.222N         P=0.223N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.093N         P=0.200N         P=0.202N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.115N         P=0.271N         P=0.265N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 10

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      |
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.4%             2.9%             2.9%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        392              695              627           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.311N         P=0.406N         P=0.433N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.357N         P=0.461N         P=0.462N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.365N         P=0.476N         P=0.477N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.345N         P=0.439N         P=0.439N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.385N         P=0.509N         P=0.529N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.378N         P=0.500N         P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       9/50 (18%)       1/50 (2%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        18.6%            25.2%            2.9%          |  0.0%             0.0%             2.8%            |
|TERMINAL (d)       |        2/8 (25%)        4/12 (33%)       0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        392              600              627           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.031N*        P=0.530          P=0.038N*     |  P=0.239          (e)              P=0.452         |
|POLY 3             |        P=0.043N*        P=0.358          P=0.041N*     |  P=0.275          (e)              P=0.464         |
|POLY 1.5           |        P=0.052N         P=0.331          P=0.046N*     |  P=0.274          (e)              P=0.475         |
|POLY 6             |        P=0.032N*        P=0.406          P=0.034N*     |  P=0.276          (e)              P=0.457         |
|LOGISTIC REGRESSION|        P=0.045N*        P=0.391          P=0.056N      |  (e)              (e)              P=0.452         |
|COCH-ARM / FISHERS |        P=0.072N         P=0.288          P=0.056N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 11

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        9.7%             8.6%             2.9%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        603              626              485           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.166N         P=0.526N         P=0.236N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.197N         P=0.608N         P=0.261N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.212N         P=0.627N         P=0.277N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.179N         P=0.583N         P=0.242N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.209N         P=0.581N         P=0.305N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.238N         P=0.661N         P=0.309N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        5/50 (10%)       3/50 (6%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        9.7%             14.3%            8.4%          |  0.0%             0.0%             2.8%            |
|TERMINAL (d)       |        1/8 (13%)        2/12 (17%)       0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        603              626              485           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.441N         P=0.546          P=0.549N      |  P=0.239          (e)              P=0.452         |
|POLY 3             |        P=0.490N         P=0.422          P=0.597N      |  P=0.275          (e)              P=0.464         |
|POLY 1.5           |        P=0.523N         P=0.398          P=0.623N      |  P=0.274          (e)              P=0.475         |
|POLY 6             |        P=0.446N         P=0.453          P=0.563N      |  P=0.276          (e)              P=0.457         |
|LOGISTIC REGRESSION|        P=0.518N         P=0.481          P=0.664       |  (e)              (e)              P=0.452         |
|COCH-ARM / FISHERS |        P=0.576          P=0.357          P=0.661N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 12

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.8%             5.7%          |  0.0%             0.0%             2.8%            |
|TERMINAL (d)       |        0/8 (0%)         1/12 (8%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        ---              725              562           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.233          P=0.350          P=0.300       |  P=0.239          (e)              P=0.452         |
|POLY 3             |        P=0.224          P=0.267          P=0.270       |  P=0.275          (e)              P=0.464         |
|POLY 1.5           |        P=0.204          P=0.256          P=0.257       |  P=0.274          (e)              P=0.475         |
|POLY 6             |        P=0.256          P=0.284          P=0.291       |  P=0.276          (e)              P=0.457         |
|LOGISTIC REGRESSION|        P=0.204          P=0.338          P=0.236       |  (e)              (e)              P=0.452         |
|COCH-ARM / FISHERS |        P=0.176          P=0.247          P=0.247       |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        6/50 (12%)       0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        9.6%             17.0%            0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         3/12 (25%)       0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        467              600              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.088N         P=0.413          P=0.103N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.105N         P=0.297          P=0.101N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.118N         P=0.277          P=0.107N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.090N         P=0.326          P=0.094N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.104N         P=0.323          P=0.121N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.146N         P=0.243          P=0.121N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 13

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        3.3%             5.7%             0.0%          |  0.0%             0.0%             2.8%            |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        729 (T)          620              ---           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.279N         P=0.617          P=0.436N      |  P=0.239          (e)              P=0.452         |
|POLY 3             |        P=0.320N         P=0.551          P=0.475N      |  P=0.275          (e)              P=0.464         |
|POLY 1.5           |        P=0.335N         P=0.531          P=0.485N      |  P=0.274          (e)              P=0.475         |
|POLY 6             |        P=0.299N         P=0.580          P=0.461N      |  P=0.276          (e)              P=0.457         |
|LOGISTIC REGRESSION|        P=0.300N         P=0.588          (e)           |  (e)              (e)              P=0.452         |
|COCH-ARM / FISHERS |        P=0.360N         P=0.500          P=0.500N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        8/50 (16%)       0/50 (0%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        12.7%            22.4%            0.0%          |  0.0%             0.0%             2.8%            |
|TERMINAL (d)       |        1/8 (13%)        4/12 (33%)       0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        467              600              ---           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.047N*        P=0.363          P=0.046N*     |  P=0.239          (e)              P=0.452         |
|POLY 3             |        P=0.059N         P=0.234          P=0.047N*     |  P=0.275          (e)              P=0.464         |
|POLY 1.5           |        P=0.071N         P=0.212          P=0.052N      |  P=0.274          (e)              P=0.475         |
|POLY 6             |        P=0.047N*        P=0.270          P=0.042N*     |  P=0.276          (e)              P=0.457         |
|LOGISTIC REGRESSION|        P=0.058N         P=0.270          P=0.053N      |  (e)              (e)              P=0.452         |
|COCH-ARM / FISHERS |        P=0.099N         P=0.178          P=0.059N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 14

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        8/50 (16%)       0/50 (0%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        12.7%            22.4%            0.0%          |  0.0%             0.0%             2.8%            |
|TERMINAL (d)       |        1/8 (13%)        4/12 (33%)       0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        467              600              ---           |  ---              ---              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.047N*        P=0.363          P=0.046N*     |  P=0.239          (e)              P=0.452         |
|POLY 3             |        P=0.059N         P=0.234          P=0.047N*     |  P=0.275          (e)              P=0.464         |
|POLY 1.5           |        P=0.071N         P=0.212          P=0.052N      |  P=0.274          (e)              P=0.475         |
|POLY 6             |        P=0.047N*        P=0.270          P=0.042N*     |  P=0.276          (e)              P=0.457         |
|LOGISTIC REGRESSION|        P=0.058N         P=0.270          P=0.053N      |  (e)              (e)              P=0.452         |
|COCH-ARM / FISHERS |        P=0.099N         P=0.178          P=0.059N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        1/50 (2%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        9.8%             2.9%             2.9%          |  0.0%             2.7%             2.8%            |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        617              729 (T)          552           |  ---              719              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.149N         P=0.201N         P=0.247N      |  P=0.281          P=0.471          P=0.452         |
|POLY 3             |        P=0.181N         P=0.261N         P=0.259N      |  P=0.299          P=0.475          P=0.464         |
|POLY 1.5           |        P=0.189N         P=0.277N         P=0.277N      |  P=0.309          P=0.482          P=0.475         |
|POLY 6             |        P=0.171N         P=0.242N         P=0.237N      |  P=0.293          P=0.471          P=0.457         |
|LOGISTIC REGRESSION|        P=0.162N         P=0.215N         P=0.266N      |  P=0.283          P=0.470          P=0.452         |
|COCH-ARM / FISHERS |        P=0.202N         P=0.309N         P=0.309N      |  P=0.331          P=0.500          P=0.500         |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 15

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        23/50 (46%)      20/50 (40%)      19/50 (38%)   |                                                    |
|POLY-3 ADJUSTED (b)|        63.6%            51.8%            50.8%         |                                                    |
|TERMINAL (d)       |        5/8 (63%)        8/12 (67%)       9/11 (82%)    |                                                    |
|FIRST INCIDENCE    |        467              499              552           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.067N         P=0.081N         P=0.080N      |                                                    |
|POLY 3             |        P=0.147N         P=0.192N         P=0.169N      |                                                    |
|POLY 1.5           |        P=0.173N         P=0.237N         P=0.198N      |                                                    |
|POLY 6             |        P=0.133N         P=0.158N         P=0.154N      |                                                    |
|LOGISTIC REGRESSION|        P=0.077N         P=0.139N         P=0.084N      |                                                    |
|COCH-ARM / FISHERS |        P=0.239N         P=0.343N         P=0.272N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        4/50 (8%)        4/50 (8%)     |  4/50 (8%)        3/50 (6%)        6/50 (12%)      |
|POLY-3 ADJUSTED (b)|        9.7%             11.3%            11.5%         |  9.4%             8.0%             16.7%           |
|TERMINAL (d)       |        2/8 (25%)        1/12 (8%)        2/11 (18%)    |  4/28 (14%)       3/24 (13%)       5/22 (23%)      |
|FIRST INCIDENCE    |        526              621              579           |  728 (T)          728 (T)          626             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.575N         P=0.645N         P=0.649       |  P=0.177          P=0.586N         P=0.227         |
|POLY 3             |        P=0.498          P=0.578          P=0.569       |  P=0.224          P=0.568N         P=0.266         |
|POLY 1.5           |        P=0.469          P=0.547          P=0.542       |  P=0.245          P=0.549N         P=0.295         |
|POLY 6             |        P=0.538          P=0.625          P=0.609       |  P=0.211          P=0.580N         P=0.249         |
|LOGISTIC REGRESSION|        P=0.508          P=0.584          P=0.594       |  P=0.182          P=0.586N         P=0.233         |
|COCH-ARM / FISHERS |        P=0.424          P=0.500          P=0.500       |  P=0.297          P=0.500N         P=0.370         |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 16

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)     |  1/50 (2%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.9%          |  2.3%             5.3%             5.6%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        1/11 (9%)     |  1/28 (4%)        2/24 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              729 (T)       |  728 (T)          728 (T)          702             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.302          (e)              P=0.564       |  P=0.313          P=0.446          P=0.424         |
|POLY 3             |        P=0.291          (e)              P=0.525       |  P=0.331          P=0.456          P=0.439         |
|POLY 1.5           |        P=0.283          (e)              P=0.515       |  P=0.349          P=0.469          P=0.457         |
|POLY 6             |        P=0.303          (e)              P=0.539       |  P=0.321          P=0.449          P=0.428         |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.564       |  P=0.310          P=0.446          P=0.422         |
|COCH-ARM / FISHERS |        P=0.269          (e)              P=0.500       |  P=0.390          P=0.500          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        4/50 (8%)        5/50 (10%)    |  5/50 (10%)       5/50 (10%)       8/50 (16%)      |
|POLY-3 ADJUSTED (b)|        9.7%             11.3%            14.3%         |  11.7%            13.3%            22.1%           |
|TERMINAL (d)       |        2/8 (25%)        1/12 (8%)        3/11 (27%)    |  5/28 (18%)       5/24 (21%)       5/22 (23%)      |
|FIRST INCIDENCE    |        526              621              579           |  728 (T)          728 (T)          626             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.442          P=0.645N         P=0.517       |  P=0.109          P=0.532          P=0.145         |
|POLY 3             |        P=0.353          P=0.578          P=0.424       |  P=0.142          P=0.550          P=0.174         |
|POLY 1.5           |        P=0.329          P=0.547          P=0.397       |  P=0.164          P=0.573          P=0.202         |
|POLY 6             |        P=0.387          P=0.625          P=0.465       |  P=0.130          P=0.536          P=0.160         |
|LOGISTIC REGRESSION|        P=0.373          P=0.584          P=0.464       |  P=0.109          P=0.532          P=0.143         |
|COCH-ARM / FISHERS |        P=0.290          P=0.500          P=0.357       |  P=0.221          P=0.630N         P=0.277         |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 17

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        1/50 (2%)     |  2/50 (4%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             8.7%             2.9%          |  4.6%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         3/12 (25%)       1/11 (9%)     |  1/28 (4%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              729 (T)          729 (T)       |  613              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.469          P=0.192          P=0.564       |  P=0.127N         P=0.286N         P=0.296N        |
|POLY 3             |        P=0.452          P=0.142          P=0.525       |  P=0.114N         P=0.268N         P=0.282N        |
|POLY 1.5           |        P=0.422          P=0.133          P=0.515       |  P=0.107N         P=0.259N         P=0.267N        |
|POLY 6             |        P=0.494          P=0.155          P=0.539       |  P=0.118N         P=0.275N         P=0.292N        |
|LOGISTIC REGRESSION|        (e)              P=0.192          P=0.564       |  P=0.102N         P=0.242N         P=0.250N        |
|COCH-ARM / FISHERS |        P=0.378          P=0.121          P=0.500       |  P=0.095N         P=0.247N         P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        1/50 (2%)     |  1/50 (2%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.4%             0.0%             2.9%          |  2.3%             2.7%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  1/28 (4%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        521              ---              701           |  728 (T)          728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.323N         P=0.217N         P=0.451N      |  P=0.384N         P=0.728          P=0.548N        |
|POLY 3             |        P=0.356N         P=0.214N         P=0.466N      |  P=0.396N         P=0.732          P=0.536N        |
|POLY 1.5           |        P=0.357N         P=0.222N         P=0.478N      |  P=0.376N         P=0.741          P=0.525N        |
|POLY 6             |        P=0.355N         P=0.204N         P=0.452N      |  P=0.409N         P=0.727          P=0.543N        |
|LOGISTIC REGRESSION|        P=0.364N         P=0.264N         P=0.498N      |  P=0.384N         P=0.728          (e)             |
|COCH-ARM / FISHERS |        P=0.360N         P=0.247N         P=0.500N      |  P=0.331N         P=0.753N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 18

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        3/50 (6%)        2/50 (4%)     |  3/50 (6%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.4%             8.7%             5.8%          |  7.0%             2.7%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         3/12 (25%)       1/11 (9%)     |  2/28 (7%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        521              729 (T)          701           |  613              728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.495N         P=0.629          P=0.624N      |  P=0.091N         P=0.372N         P=0.170N        |
|POLY 3             |        P=0.553N         P=0.547          P=0.661N      |  P=0.083N         P=0.355N         P=0.156N        |
|POLY 1.5           |        P=0.567N         P=0.531          P=0.673N      |  P=0.075N         P=0.340N         P=0.144N        |
|POLY 6             |        P=0.536N         P=0.566          P=0.648N      |  P=0.090N         P=0.365N         P=0.165N        |
|LOGISTIC REGRESSION|        P=0.518N         P=0.572          P=0.666N      |  P=0.081N         P=0.349N         P=0.146N        |
|COCH-ARM / FISHERS |        P=0.594          P=0.500          P=0.691N      |  P=0.060N         P=0.309N         P=0.121N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  6/50 (12%)       6/50 (12%)       5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                                                        |  13.8%            15.9%            13.9%           |
|TERMINAL (d)       |                                                        |  4/28 (14%)       5/24 (21%)       3/22 (14%)      |
|FIRST INCIDENCE    |                                                        |  585              689              665             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.522          P=0.508          P=0.595         |
|POLY 3             |                                                        |  P=0.553          P=0.521          P=0.622         |
|POLY 1.5           |                                                        |  P=0.539N         P=0.552          P=0.591N        |
|POLY 6             |                                                        |  P=0.523          P=0.499          P=0.596         |
|LOGISTIC REGRESSION|                                                        |  P=0.538          P=0.521          P=0.624         |
|COCH-ARM / FISHERS |                                                        |  P=0.437N         P=0.620N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 19

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  6/50 (12%)       6/50 (12%)       6/50 (12%)      |
|POLY-3 ADJUSTED (b)|                                                        |  13.8%            15.9%            16.4%           |
|TERMINAL (d)       |                                                        |  4/28 (14%)       5/24 (21%)       3/22 (14%)      |
|FIRST INCIDENCE    |                                                        |  585              689              466             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.395          P=0.508          P=0.462         |
|POLY 3             |                                                        |  P=0.437          P=0.521          P=0.499         |
|POLY 1.5           |                                                        |  P=0.475          P=0.552          P=0.536         |
|POLY 6             |                                                        |  P=0.413          P=0.499          P=0.476         |
|LOGISTIC REGRESSION|                                                        |  P=0.433          P=0.521          P=0.536         |
|COCH-ARM / FISHERS |                                                        |  P=0.561          P=0.620N         P=0.620N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.2%             5.6%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        540              529              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.326N         P=0.547          P=0.480N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.326N         P=0.551          P=0.479N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.339N         P=0.531          P=0.487N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.311N         P=0.578          P=0.469N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.415N         P=0.433          P=0.543N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.360N         P=0.500          P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 20

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        16/50 (32%)      10/50 (20%)      12/50 (24%)   |  10/50 (20%)      9/50 (18%)       4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        45.0%            26.8%            32.3%         |  22.8%            22.6%            11.2%           |
|TERMINAL (d)       |        3/8 (38%)        3/12 (25%)       3/11 (27%)    |  5/28 (18%)       5/24 (21%)       3/22 (14%)      |
|FIRST INCIDENCE    |        470              529              474           |  618              280              672             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.085N         P=0.044N*        P=0.100N      |  P=0.158N         P=0.554          P=0.173N        |
|POLY 3             |        P=0.155N         P=0.075N         P=0.181N      |  P=0.141N         P=0.595N         P=0.144N        |
|POLY 1.5           |        P=0.171N         P=0.089N         P=0.202N      |  P=0.111N         P=0.567N         P=0.117N        |
|POLY 6             |        P=0.140N         P=0.063N         P=0.164N      |  P=0.170N         P=0.592          P=0.168N        |
|LOGISTIC REGRESSION|        P=0.150N         P=0.086N         P=0.176N      |  P=0.096N         P=0.528N         P=0.140N        |
|COCH-ARM / FISHERS |        P=0.210N         P=0.127N         P=0.252N      |  P=0.063N         P=0.500N         P=0.074N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             5.2%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              533              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.621          P=0.211          (e)             |
|POLY 3             |        (e)              (e)              (e)           |  P=0.605          P=0.213          (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.625          P=0.220          (e)             |
|POLY 6             |        (e)              (e)              (e)           |  P=0.591          P=0.210          (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.659N         P=0.254          (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 21

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.5%             2.9%             2.9%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        607              729 (T)          508           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.307N         P=0.386N         P=0.430N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.352N         P=0.458N         P=0.454N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.362N         P=0.473N         P=0.472N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.341N         P=0.438N         P=0.431N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.353N         P=0.418N         P=0.497N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.378N         P=0.500N         P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Malignant                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.5%             2.9%             2.9%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        607              729 (T)          508           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.307N         P=0.386N         P=0.430N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.352N         P=0.458N         P=0.454N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.362N         P=0.473N         P=0.472N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.341N         P=0.438N         P=0.431N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.353N         P=0.418N         P=0.497N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.378N         P=0.500N         P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 22

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        48/50 (96%)      49/50 (98%)      46/50 (92%)   |  43/50 (86%)      39/50 (78%)      34/50 (68%)     |
|POLY-3 ADJUSTED (b)|        99.3%            99.7%            95.9%         |  89.8%            91.3%            82.8%           |
|TERMINAL (d)       |        8/8 (100%)       12/12 (100%)     11/11 (100%)  |  26/28 (93%)      23/24 (96%)      19/22 (86%)     |
|FIRST INCIDENCE    |        334              444              329           |  522              382              373             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.092N         P=0.134N         P=0.105N      |  P=0.523          P=0.404          P=0.557N        |
|POLY 3             |        P=0.117N         P=0.991          P=0.291N      |  P=0.187N         P=0.558          P=0.235N        |
|POLY 1.5           |        P=0.110N         P=0.864          P=0.243N      |  P=0.085N         P=0.546N         P=0.118N        |
|POLY 6             |        P=0.166N         P=1.000          P=0.420N      |  P=0.320N         P=0.394          P=0.363N        |
|LOGISTIC REGRESSION|        P=0.073N         P=0.596N         P=0.151N      |  P=0.250N         P=0.544          P=0.267N        |
|COCH-ARM / FISHERS |        P=0.238N         P=0.500          P=0.339N      |  P=0.021N*        P=0.218N         P=0.028N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        25/50 (50%)      20/50 (40%)      21/50 (42%)   |  19/50 (38%)      20/50 (40%)      15/50 (30%)     |
|POLY-3 ADJUSTED (b)|        63.5%            51.6%            51.8%         |  42.4%            48.9%            40.0%           |
|TERMINAL (d)       |        5/8 (63%)        6/12 (50%)       5/11 (46%)    |  11/28 (39%)      13/24 (54%)      9/22 (41%)      |
|FIRST INCIDENCE    |        392              529              389           |  493              280              466             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.089N         P=0.052N         P=0.103N      |  P=0.525          P=0.288          P=0.570N        |
|POLY 3             |        P=0.158N         P=0.182N         P=0.186N      |  P=0.497N         P=0.347          P=0.505N        |
|POLY 1.5           |        P=0.182N         P=0.180N         P=0.210N      |  P=0.406N         P=0.391          P=0.424N        |
|POLY 6             |        P=0.136N         P=0.193N         P=0.164N      |  P=0.539          P=0.316          P=0.563N        |
|LOGISTIC REGRESSION|        P=0.171N         P=0.124N         P=0.230N      |  P=0.416N         P=0.381          P=0.480N        |
|COCH-ARM / FISHERS |        P=0.240N         P=0.211N         P=0.274N      |  P=0.233N         P=0.500          P=0.263N        |
|=================================================================================================================================|
       Date:  02/24/99                           EXPERIMENT: 55312 TEST: 03                                            Page 23

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        49/50 (98%)      49/50 (98%)      48/50 (96%)   |  48/50 (96%)      43/50 (86%)      37/50 (74%)     |
|POLY-3 ADJUSTED (b)|        100.0%           99.7%            96.9%         |  97.8%            95.8%            86.9%           |
|TERMINAL (d)       |        8/8 (100%)       12/12 (100%)     11/11 (100%)  |  27/28 (96%)      24/24 (100%)     19/22 (86%)     |
|FIRST INCIDENCE    |        334              444              329           |  493              280              373             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.115N         P=0.111N         P=0.129N      |  P=0.466N         P=0.433          P=0.483N        |
|POLY 3             |        P=0.126N         P=1.000N         P=0.318N      |  P=0.015N*        P=0.522N         P=0.038N*       |
|POLY 1.5           |        P=0.132N         P=0.962N         P=0.292N      |  P=0.004N**       P=0.256N         P=0.010N*       |
|POLY 6             |        P=0.163N         P=1.000N         P=0.426N      |  P=0.044N*        P=0.796          P=0.094N        |
|LOGISTIC REGRESSION|        P=0.189N         P=0.228N         P=0.357N      |  P=0.028N*        P=0.438N         P=0.047N*       |
|COCH-ARM / FISHERS |        P=0.378N         P=0.753N         P=0.500N      |  P<0.001N**       P=0.080N         P=0.002N**      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).