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TDMS Study 55312-03 Pathology Tables

NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99
Route: SKIN APPLICATION                                                                                           Time: 08:08:22

                                                      2 YEAR CHRONIC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  68603-42-9

       Lock Date:  09/06/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1



NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2|             
                                           | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X                  |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                             X     X                 X               |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X              X     X              X  X     X  X  X  X  X  X|             
      Clear Cell Focus                     | X                          X                    X                        |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           | X  X        X     X              X  X                    X              X|             
      Inflammation, Chronic                |    1  2  2  2  3  1        1  2  1  2  1  1        1     1  1     1  1   |             
      Mixed Cell Focus                     |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |             1           2  2  3  1        3  1     1     1        1     2|             
      Bile Duct, Hyperplasia               | 1        1  1           1     1     1  1           1     1     1         |             
      Hepatocyte, Hyperplasia, Adenomatous |                                                                          |             
      Hepatocyte, Necrosis                 |                                                                          |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration                     |                                           3                              |             
      Hepatocyte, Centrilobular, Necrosis  |                                           3                              |             
      Serosa, Necrosis, Fibrinoid          |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               | +                 +                                                      |             
      Fat, Necrosis                        | 4                 4                                                      |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Hyperplasia, Squamous      |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                2                                                         |             
      Acinus, Atrophy                      | 2           3     2  2                                                   |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Epithelium, Ulcer                    |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Ulcer                    |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Inflammation, Chronic Active         |                      3                                                   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2|             
                                           | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    2  2     2     1  2     1     1  1     1  1        2                 2|             
      Inflammation, Chronic Active         |                3                                                         |             
      Mineralization                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    3        2        2                                            2     3|             
      Degeneration, Fatty                  |    1           1     1  2     1           2                 1  1  2     1|             
      Fibrosis                             |                                                                         2|             
      Hyperplasia                          |    4     2  1           2     1           3        1              2  2  2|             
      Hypertrophy                          |    2        2        2                    2                 2     2  1   |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                                                   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  M|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    2                 2  2  2              2  2  2                    2   |             
      Pars Distalis, Hyperplasia           |    2        3  2     2  2  2                 2     2  1  3        3  2   |             
      Pars Intermedia, Cyst                |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1     2              2  2     1           1     2        1  1  2     1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2     3                                       |             
      Inflammation, Chronic Active         |             1                                1           2               |             
      Duct, Cyst                           |                                                          3               |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      4     2           4  3           4                  |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                          4               |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                4     4  4                 3           4                  |             

                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +     +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2|             
                                           | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Inguinal, Ectasia                    |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      | 1  2  1  1  1  1  1  1     1  2  1  1     1     1  2  1  2  2     1     2|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                     2                                    |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                2                          4                              |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                     3                                    |             
      Capsule, Inflammation, Granulomatous |                4                                                         |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2     2  3  2  2  2  2  2  2  2  2     2     1  1  1  2  2  2  1  2  2  3|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  |                1                                                         |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |                1                                                         |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Parakeratosis                   |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |                                                                          |             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         |                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic Active     |                1                                                         |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                           3              3               |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Inflammation, Chronic Active         |                3                                                         |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2|             
                                           | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |       2     1                                                            |             
      Inflammation, Granulomatous          |          1     3                                                         |             
      Alveolar Epithelium, Hyperplasia     | 4                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1  1  1           1  1  1     1           1     1              1     1|             
      Mediastinum, Necrosis                |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                1                                            2     1      |             
      Respiratory Epithelium, Hyperplasia  |                                                             3            |             
      Vein, Turbinate, Septum, Thrombosis  |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                +  +  +   |             
      Anterior Chamber, Cornea, Iris,      |                                                                          |             
          Synechia                         |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Lens, Cataract                       |                                                                2  4      |             
      Retina, Atrophy                      |                                                                   4      |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Cyst                                 |                   2                                                      |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Nephropathy, Chronic                 | 1  1  2  2  2  1  1  1  2  2  2  2  1  1  2  1  2  2  1  2  2  2  2  1  2|             
      Pigmentation, Hemosiderin            | 1  1  1  1  1  2  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2|            |
                                           | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    0 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                           X                              |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | X                          X                                             |      6     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X                                                               |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X  X        X  X  X  X     X     X  X  X  X     X        X  X  X  X|     31     |
      Clear Cell Focus                     |       X                    X                                             |      5     |
      Fibrosis                             |                2                                                         |      1  2.0|
      Hepatodiaphragmatic Nodule           |                            X                                      X      |     10     |
      Inflammation, Chronic                |       2  1              2  1     2     1  1  1        1  1     2     1   |     29  1.4|
      Mixed Cell Focus                     |                                              X                           |      1     |
      Pigmentation, Hemosiderin            |                   2                                                      |      1  2.0|
      Vacuolization Cytoplasmic            |       1  1        1  1     1        3  1  1                 1  1     2  1|     23  1.4|
      Bile Duct, Hyperplasia               | 2     1  1     2  2  1        2     2  1     1  1     1     1  1     1  1|     26  1.2|
      Hepatocyte, Hyperplasia, Adenomatous |                3                                                         |      1  3.0|
      Hepatocyte, Necrosis                 |                   2                                                      |      1  2.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration                     |                                     2                                    |      2  2.5|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
      Serosa, Necrosis, Fibrinoid          |                                     3                                    |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                   +                                    |   4        |
      Fat, Necrosis                        |                                     4                                    |      3  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             | +                                                                        |   1        |
      Gingival, Hyperplasia, Squamous      | 3                                                                        |      1  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Acinus, Atrophy                      | 1     1           1  1  3  1     4     1  2     1     1     2     1  1  1|     19  1.6|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                               3                                          |      1  3.0|
      Epithelium, Hyperplasia              |                               3                             2            |      2  2.5|
      Epithelium, Ulcer                    |                               4                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2|            |
                                           | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    0 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Ulcer                    |    4                                                                     |      1  4.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |          1     2  2  2  2                 1              1  2     1     1|     22  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                             1            |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |    2                                                     1              2|      8  2.1|
      Degeneration, Fatty                  | 2        1        1           4     4  1        2  1  1  1  2  1         |     22  1.5|
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          | 2        2     2     2  1  2                    2  1  1  2  3  2         |     22  1.9|
      Hypertrophy                          | 2                 2                                      2               |     10  1.9|
      Necrosis                             |    4                                                                     |      1  4.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +|  42        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  | 3     2  2  2        2     2  2     1        3  3  2  2           2  2  3|     23  2.1|
      Pars Distalis, Hyperplasia           |    2              2           2     3           3  1              2  2   |     20  2.2|
      Pars Intermedia, Cyst                |                                                    1                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       1                    2           1  1                       1  2   |     17  1.4|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                           1                    2         |      4  2.0|
      Inflammation, Chronic Active         |          2                                      3           3            |      6  2.0|
      Duct, Cyst                           |                                                             3            |      2  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2|            |
                                           | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    0 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              2                 3         |      7  3.1|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                     4                                    |      1  4.0|
      Hyperplasia                          | 4  3           4              4     4              4        3            |     12  3.8|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +      |  41        |
      Pigmentation, Hemosiderin            |                                                    1                     |      1  1.0|
      Inguinal, Ectasia                    |                                                    2                     |      1  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 1     2  1  1  2  2     2  2  1  1  1  1  2  1        2     1  1  1      |     38  1.3|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 3                                                                        |      1  3.0|
      Hematopoietic Cell Proliferation     |    3                                                                     |      3  3.0|
      Necrosis                             |                               4                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Capsule, Inflammation, Granulomatous |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  | 2  1  2  2     2  2  2  2  2  2  2  3  2  1  2  3  2     2  2  1  2     2|     44  1.9|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  |                      2                                   1               |      3  1.3|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                      3                                   3               |      3  2.3|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Parakeratosis                   |                                                          1               |      1  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           |                      4                                   1               |      2  2.5|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         |                      2                                   1               |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2|            |
                                           | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    0 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic Active     |                      3                                   3               |      3  2.3|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                  +                  |   3        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                  3                                       |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       1                    2                 2  1                 1      |      7  1.4|
      Inflammation, Granulomatous          | 3                                                                        |      3  2.3|
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |      2  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1                          1  1        1     2  1  1           1  1  1  1|     22  1.0|
      Mediastinum, Necrosis                |                                     3                                    |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                           2                              |      4  1.5|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  3.0|
      Vein, Turbinate, Septum, Thrombosis  |                                     4                                    |      1  4.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                +  +                                            +         |   6        |
      Anterior Chamber, Cornea, Iris,      |                                                                          |            |
          Synechia                         |                4                                                         |      1  4.0|
      Cornea, Inflammation, Chronic        |                2                                                         |      1  2.0|
      Lens, Cataract                       |                2  2                                            3         |      5  2.6|
      Retina, Atrophy                      |                   4                                            4         |      3  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2|            |
                                           | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    0 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Accumulation, Hyaline Droplet        |    2                                               3                     |      2  2.5|
      Cyst                                 |                                                                      2   |      2  2.0|
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1|     50  1.0|
      Nephropathy, Chronic                 | 2     2  2     2  1  2  1  2  2  1  2  2  2  1  2  1  1     2  2  1  2  2|     47  1.6|
      Pigmentation, Hemosiderin            | 3  1  2  1     1  1  1  1  1  1  1  1  1  3  3  1  1  1  1  2     1  2  2|     48  1.3|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5|             
                             DAY ON TEST   | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7|             
                                           | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X              X                                                         |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X  X                                         X               |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X     X     X           X                       X                    X|             
      Clear Cell Focus                     |          X                                                               |             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Hepatodiaphragmatic Nodule           |          X     X           X           X        X  X                    X|             
      Inflammation, Chronic                | 2  1  1  1  1  1           2  1           1  1     1        1     1     1|             
      Mixed Cell Focus                     | X                                                                       X|             
      Vacuolization Cytoplasmic            |          2  1  1        1     1  2  2  2           1     1               |             
      Bile Duct, Hyperplasia               |                   2  3  1     1  2        1  1     1        2           1|             
      Hepatocyte, Hyperplasia, Adenomatous |                                        4                                 |             
      Hepatocyte, Necrosis                 |                                                                          |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration                     |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Fat, Necrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                      +                                                   |             
      Pharyngeal, Hyperplasia, Squamous    |                      4                                                   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    1           1  1  2  2        2              2                        |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic Active         |                      3                          2                        |             
      Mineralization                       |                      3                                                   |             
      Epithelium, Hyperplasia              |                                     3           2                        |             
      Epithelium, Ulcer                    |                      4              4                                    |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Epithelium, Erosion                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5|             
                             DAY ON TEST   | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7|             
                                           | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                   2                                         1  2         |             
      Atrium, Thrombosis                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                3         |             
      Atrophy                              |                            2                                             |             
      Degeneration, Cystic                 |                                  1                          3  3         |             
      Degeneration, Fatty                  |             2           1        2  1        1  1  1     1               |             
      Hyperplasia                          | 2                       1        1     1     2     2     2               |             
      Hypertrophy                          |                                  2                             3         |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    3     2     2     3  3     2  2  2  2        2  2        1  2     1  2|             
      Pars Distalis, Hyperplasia           |    2  2     2  2              2     2  2           2           2  1  2  3|             
      Pars Intermedia, Cyst                |                                                                      2   |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Thymus                       |                                                                          |             
      C-Cell, Hyperplasia                  |                                     1              2  1        1         |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                              3  3        2           2   |             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2              2                                4              2         |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4              4  4           4              3              3         |             

                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +     +     +  +  +  +  +              +     +     +|             
      Mediastinal, Pigmentation,           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5|             
                             DAY ON TEST   | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7|             
                                           | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Hemosiderin                      |    1  2  1  2  1  1  1     2        1  1  1  1              2     1     2|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3                                                                     |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    4           4                                                         |             
      Hyperplasia, Cystic                  | 2  2     3  2     2  2        2  2  2     2  2  2  2  2  2     2        1|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                   X                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  | 2  2  1  2  1  2  2     1  1  2  4  1  2  1  2  2  1  2  1  2     1  1  1|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     | 2  2  2  2     2  1     1  3  2  2  1  2  2  3  2  1  1  1  2  2  2  1  2|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Parakeratosis                   | 2        1                    1  2     1                                1|             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         | 2  2  2  2  1  2  1     1  1  2  2  1  2  2  2  2  1  1  1  2  2  2  1  2|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Osteopetrosis                        |                               3                                          |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         | 1        2                             1           1        1           1|             
      Inflammation, Granulomatous          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5|             
                             DAY ON TEST   | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7|             
                                           | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          1  1  1        1  1  1        1        1  1  1  1  1     1     1|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                3     3   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                     2                                    |             
      Respiratory Epithelium, Hyperplasia  |                                                                3     3   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                      3   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Lens, Cataract                       |                                                 4                        |             
      Retina, Atrophy                      |                                                 4                        |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  1  1  1  1     1  1  1  1  1  1  1  1  1     1  1  1  1  1     2  1  1|             
      Nephropathy, Chronic                 | 2  1  1  3  2  2  2  1  2     2  2  2  2  1  2  3  3  2  3  2  2        1|             
      Pigmentation, Hemosiderin            |    1  1  2  1  1  3  1  1  1  1  2  1     1  1  1  2  1  1  1  2        1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |          2                                                               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2|            |
                                           | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    50 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X              X        X                                 |      5     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X                                                                  |      4     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X        X              X     X  X  X  X           X     X     X  X|     17     |
      Clear Cell Focus                     |                                     X  X     X                           |      4     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                     X  X                       X     X   |     11     |
      Inflammation, Chronic                | 1  2        1  1     1        1              1  1     1  2           2  1|     26  1.2|
      Mixed Cell Focus                     |                                                                          |      2     |
      Vacuolization Cytoplasmic            |       2     1        2              1     1  1           1     2     2  1|     20  1.4|
      Bile Duct, Hyperplasia               | 1           1  1     1  1  1  1     1  1        1     1                  |     21  1.2|
      Hepatocyte, Hyperplasia, Adenomatous |                                                                          |      1  4.0|
      Hepatocyte, Necrosis                 |                   3  2                                                   |      2  2.5|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration                     |                                  4                                       |      1  4.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +                       +                             +      |   5        |
      Fat, Necrosis                        |          4  4                       4                             4      |      4  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Pharyngeal, Hyperplasia, Squamous    |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1                    1  1  1        3                                2   |     13  1.5|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                   3      |      1  3.0|
      Inflammation, Chronic Active         |                                                                   2      |      3  2.3|
      Mineralization                       |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                      3           2                                3      |      5  2.6|
      Epithelium, Ulcer                    |                                                                   4      |      3  4.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |       2                                                                  |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2|            |
                                           | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    50 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Erosion                  |                                  3                                       |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |       2                                                                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |    1  2                                1  1  2  2  1  1  2     2  1  2  2|     16  1.6|
      Atrium, Thrombosis                   |                                  3                                       |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  2.0|
      Degeneration, Cystic                 |             2                    3              2                        |      6  2.3|
      Degeneration, Fatty                  |    1        2  2  1                 1                          1         |     14  1.3|
      Hyperplasia                          |    2           2     1                       1           2     1        2|     14  1.6|
      Hypertrophy                          |             3                                                            |      3  2.7|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1                                                        2         |      2  1.5|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |       3                                                                  |      1  3.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |       2  2     3           2     2  2  2  2  2           4        3     2|     27  2.2|
      Pars Distalis, Hyperplasia           |    2  2  2                 2     2           3                          3|     19  2.1|
      Pars Intermedia, Cyst                |                                     2                                    |      2  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectopic Thymus                       |                                              3                           |      1  3.0|
      C-Cell, Hyperplasia                  |    1                                                  2              1   |      7  1.3|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                      2   |      1  2.0|
      Inflammation, Chronic Active         |                                                             1        2   |      6  2.2|
      Duct, Cyst                           |                                                          3               |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2|            |
                                           | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    50 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                               4           2                    4     4   |      8  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                   4                                                      |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                                                                         3|      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       4        4  4  4        4                             4  4  4      |     14  3.9|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +     +|  36        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |    1  2  2     2  1  2  1  1  2     2  2  2  1  2  1  1  1  1     1     1|     35  1.4|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |       2        2  3                                                      |      4  2.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      4                                                   |      3  4.0|
      Hyperplasia, Cystic                  | 2  2  2  2     2  4  2  2  2  2  2  3  1  1  1  1     3  2  1  2  2  2  2|     40  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                       X                  |      2     |
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
      Epidermis, Hyperplasia               |                                                          3               |      1  3.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  | 2  2  2  1     2  2  1  1  1  2  2     1  2  2  1  2  2  2  1  1     1  2|     45  1.6|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 2  2  2  1  1  2  2  2  1  1  2  1     1  1  2  2  2  2  2  1  2     2  2|     46  1.7|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Parakeratosis                   | 1  1              1                                   1     1            |     11  1.2|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         | 2  2  2  2  1  2  2  2     1  2  1     1  1  2  2  2  2  2  1  2     2  2|     46  1.7|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |       3                                                        2         |      2  2.5|
      Osteopetrosis                        |                                  3                                       |      2  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2|            |
                                           | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    50 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                   3      |      1  3.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                   +      |   1        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                   +      |   1        |
      Hemorrhage                           |                                                                   1      |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                    4                     |      1  4.0|
      Hemorrhage                           |                                                                   1      |      1  1.0|
      Inflammation, Chronic Active         | 1                       2  1  1     1  1  2           2        2     1   |     16  1.3|
      Inflammation, Granulomatous          |                               1                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |          1  1        1                 1  1  1        1        1     1  1|     24  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                   2                                   3                  |      4  2.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |          2                                                        3      |      3  2.3|
      Respiratory Epithelium, Hyperplasia  |                   2                                   3                  |      4  2.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   2        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       | 1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1|     45  1.0|
      Nephropathy, Chronic                 | 3  2  4  1  2  2  2  2  2  1  2  1  2  2  2  3  1     3  2  2  4  2  3  2|     46  2.1|
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  2|     46  1.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9|             
                                           | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                       X                                       |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Ulcer                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X           X           X  X     X        X                              |             
      Inflammation, Chronic                | 1           2           1  1  1                                1         |             
      Vacuolization Cytoplasmic            | 3  1  3  1  1           1  1  2  3           1           1  2     1      |             
      Bile Duct, Hyperplasia               | 1        1        1  1  1                    1  1           1     1      |             
      Hepatocyte, Degeneration, Cystic     |                                                                      1   |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration                     |                                           4                 3            |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |    +                                                                     |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Pharyngeal, Hyperplasia, Squamous    |    4                                                                     |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                          1  2  1  1  1   |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    3                                         4                           |             
      Inflammation, Chronic Active         |       3        3                 3        2  3              3            |             
      Epithelium, Hyperplasia              |    2  3     3  3                 3        3  3              4            |             
      Epithelium, Ulcer                    |    2  4        4                 4        4  2              4            |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2                                                            |             
      Epithelium, Erosion                  |                                           2                              |             
      Epithelium, Hyperplasia              |                                                          2               |             
      Glands, Hyperplasia                  |                                                                          |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9|             
                                           | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |             2                                                            |             
      Pulmonary Artery, Mineralization     |             2                                                            |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  1     2  3                       2        1                 1         |             
      Mineralization                       |             1                                                            |             
      Atrium, Thrombosis                   |       4                                   3                 3            |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 1     3     2                                            2           2   |             
      Degeneration, Fatty                  |       3     2  1           2     1        2  1           2  2            |             
      Hyperplasia                          |       1     1                 2  2           1        2                  |             
      Hypertrophy                          | 1     3     2                    2                       2               |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                               2        2   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |             2                    1                                       |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |          2              2     2        2           2  1     2     2      |             
      Pars Distalis, Hyperplasia           |    2  3  2           2  3     4     2     2           2  2  2            |             
      Pars Intermedia, Cyst                |                                     2  2                                 |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2                 2           2              1     2        1            |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2           2           1        2     2                          2  1   |             
      Bilateral, Duct, Cyst                |                                                                          |             
      Duct, Cyst                           |                         2                                                |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       4                       3           2     2                        |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Vagina                                  |                      +                                                   |             
      Inflammation, Suppurative            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9|             
                                           | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 3           4  4                    4     4  3     3        4            |             

                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +        +  +     +  +     +     +  +  +|             
      Mediastinal, Congestion              |                                                             3            |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      | 2  1  2  1  1  1  1  1     1  1  1        1  1     1  1           1  1  2|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             3            |             
      Hematopoietic Cell Proliferation     |                                     3                                    |             
      Capsule, Fibrosis                    |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  1  3  2  2     2  4  2  2        2  3  2  2  2     3     2  2   |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        2                          1      |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  | 2     2  2  2  3  1  2  2  2  2  3  2  2  2  2  2  1  2  2  2  1  2  2  1|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     | 3  2  3  2  3  3  3  2  2  3  3  3  2  2  2  2  2  1  3  3  3  1  3  2  2|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Parakeratosis                   | 2  1  3     1  3  2  2     2     3     2  2  1           2  2            |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |       3        2                 4     2                    1            |             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         | 2  2  2  2  2  2  3  2  2  2  3  2  2  2  1  2  2  1  3  3  2  1  3  3  2|             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic Active     |       2        2                 2                          2            |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |             2                                         2                  |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1           2                                                  1      |             
      Inflammation, Granulomatous          |                                                                          |             
      Metaplasia, Osseous                  |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9|             
                                           | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1  1     1  1  1     1     1  1  1  1     1  1  1        1     1      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                          2                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2                                                        3   |             
      Respiratory Epithelium, Hyperplasia  |                      3                          2                        |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                      3                          2                        |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |             +                                   +                        |             
      Bilateral, Inflammation, Suppurative |             4                                                            |             
      Lens, Cataract                       |                                                 2                        |             
      Retina, Atrophy                      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  2                                       |             
      Mineralization                       | 1  2  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  2  1     1     1  2|             
      Nephropathy, Chronic                 | 3  4  4  4  4  4  3  2  2  3  3  3  2  2  2  4  1  3  3  3  2     2  2  1|             
      Pigmentation, Hemosiderin            | 2  2  1  2  1  1  1  1  2  2  1  1  1  2  2  1     2  1  1  3  1  1  1  1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2|            |
                                           | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    100                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Perforation                          |             X                                                            |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X              X           X              X                           |      6     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Ulcer                    |                                        4                                 |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |          X        X                                         X           X|      4     |
      Clear Cell Focus                     |                   X                                                      |      1     |
      Hepatodiaphragmatic Nodule           |       X           X     X           X     X     X     X        X         |     14     |
      Inflammation, Chronic                |       2  1        1                                1  1     1     1      |     13  1.2|
      Vacuolization Cytoplasmic            |       1           1        1        2  3     1        1              2  1|     22  1.5|
      Bile Duct, Hyperplasia               | 1                          1     1              1     1  2        1      |     16  1.1|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      1  1.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration                     |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +                                                               |   2        |
      Fat, Inflammation, Chronic Active    |          4                                                               |      1  4.0|
      Fat, Necrosis                        | 4                                                                        |      1  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |       +                                                              +   |   3        |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                      3   |      1  3.0|
      Pharyngeal, Hyperplasia, Squamous    |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |             1              1        1     1     1                 1      |     11  1.1|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |          3                          3  2                             3   |     10  2.8|
      Epithelium, Hyperplasia              |          4                          2  3                    2        3   |     13  2.9|
      Epithelium, Ulcer                    |          4                          4  3                             4   |     11  3.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Epithelium, Erosion                  |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2|            |
                                           | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    100                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
      Glands, Hyperplasia                  |                               2                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
      Hyperplasia, Squamous                |                            4                                             |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
      Pulmonary Artery, Mineralization     |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |          2              1  2           2              1        1        1|     14  1.5|
      Mineralization                       |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      3  3.3|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |       1        3           3                                             |      8  2.1|
      Degeneration, Fatty                  |       1        3           3        2  3                 2  2            |     16  2.0|
      Hyperplasia                          |       2        1           3                             3  2            |     11  1.8|
      Hypertrophy                          |                            3        1                                    |      7  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      3  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  45        |
      Hyperplasia                          |                                     1                                    |      3  1.3|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |       2     2  2     1     2           2     2  2              2         |     17  1.9|
      Pars Distalis, Hyperplasia           |    2           2     1  2  2                 1  2        3               |     19  2.2|
      Pars Intermedia, Cyst                |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                                         1|      7  1.6|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                             2                 2               |      3  2.0|
      Inflammation, Chronic Active         |             1                                                            |      8  1.6|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2|            |
                                           | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    100                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Duct, Cyst                |                                        3                                 |      1  3.0|
      Duct, Cyst                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                2        3                 3              2               |      8  2.6|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Vagina                                  |                                     +                                    |   2        |
      Inflammation, Suppurative            |                                     3                                    |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        3                 4               |     10  3.6|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +        +     +  +  +  +  +  +  +        +     +  +     +|  36        |
      Mediastinal, Congestion              |                                                                          |      1  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 1  1  1  1     2        1     2  1  1  1  2  2  2              1  1     1|     34  1.2|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Capsule, Fibrosis                    |                                        2                                 |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 2  2  2  2     2  1  2  3  2     2  2  2  2     2     2  2  1  2  2  2  2|     40  2.1|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  | 2  2  2  2  1  2     1  1  2  1  1  2  2  1  2     1  2  1  1  1  2  2  2|     47  1.7|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 2  3  3  3  2  3  1  2  2  3  2  2  2  3  2  3  1  2  2  4  1  1  2  2  3|     50  2.3|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Parakeratosis                   | 2  1  3                    1        1  2           2     3           3   |     23  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           | 2           2  2           2                                             |      9  2.2|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         | 2  2  3  3  1  3  1  1  1  3  1  1  2  2  2  3  1  2  1  3     2  2  2  3|     49  2.0|
      Skin, Site of Application,           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2|            |
                                           | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    100                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Inflammation, Chronic Active     | 2              2                                                         |      6  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |          1        2        1                    2     2  1               |      9  1.4|
      Inflammation, Granulomatous          |                                              1                           |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                            2                                2            |      3  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       1  1     1     1     1           1  1  1  1        1  1  1        1|     28  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                         2                                                |      3  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                2                                                         |      3  2.3|
      Respiratory Epithelium, Hyperplasia  |                         2                                                |      3  2.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +        +                 +                                             |   5        |
      Bilateral, Inflammation, Suppurative |                                                                          |      1  4.0|
      Lens, Cataract                       | 3        4                 4                                             |      4  3.3|
      Retina, Atrophy                      | 4        4                 4                                             |      3  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Mineralization                       | 2  1  1  1  1  1  1  1  1  2  2  1  1     1  1  1  1  2  1  1  1  1  1  1|     47  1.2|
      Nephropathy, Chronic                 |       2  3  1  3  3     2  3  1  2  4  4  2  3  3  1  3  3  3  2  2  3  3|     46  2.7|
      Pigmentation, Hemosiderin            | 1  1  2  1  1  2  1  1  1  2  1  1  1  1  1  2  2        3  1  1  1  1  1|     47  1.4|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                                     2                    3               |      2  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        


                                                             Page  26                                                               
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5|             
                             DAY ON TEST   | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4|             
                                           | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X        X                                       |             
      Clear Cell Focus                     |       X                 X                                            X   |             
      Hepatodiaphragmatic Nodule           | X           X                                                     X      |             
      Inflammation, Chronic                |    1        1     1     1           1  1     1        1           1  2   |             
      Mineralization                       |                                                                          |             
      Vacuolization Cytoplasmic            |    1  2  2  1     1  1  1        3  2                 2  2     2     1  1|             
      Bile Duct, Hyperplasia               | 3  1  1     1  2  1  2  1  2  2  2  1  1  2  2  3  1  2     2  1  2  2  2|             
      Hepatocyte, Degeneration, Cystic     |       1     1                             1     2  1        1  1         |             
      Hepatocyte, Necrosis                 | 1                                                                        |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration                     |                                                                         3|             
      Hepatocyte, Centrilobular, Necrosis  |                            3                                             |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +                                      +  +                       +|             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Necrosis                        |       4                                      4  4                       4|             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                   +      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2              2                    2  1  2     1           1      |             
      Artery, Inflammation, Chronic Active |             3                                                            |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                   3                 3              3                     |             
      Inflammation, Chronic Active         |       2                             2           2           2  2         |             
      Mineralization                       |             3     3                                      3     2         |             
      Perforation                          |                                                 X                        |             
      Epithelium, Hyperplasia              |       3              2           2              3  3  3     3  3         |             
      Epithelium, Ulcer                    |       4                             4           4           2            |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                                   |             
      Mineralization                       |             3     3  2                                   3     2         |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5|             
                             DAY ON TEST   | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4|             
                                           | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Aorta, Mineralization                |             3     3                    2                 4     3         |             
      Pulmonary Artery, Mineralization     |             3     3                                      4     3         |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2     2  2  3  2  3  2  2     2  1     3  2  2     2  2  3     3  2      |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |             3     2                                      3     2         |             
      Atrium, Thrombosis                   |                            3                             4     4         |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                  2                                       |             
      Degeneration, Fatty                  |    1  2  1     1     2           2  1  2     1     2  2  2  2  2  1  1  1|             
      Hyperplasia                          |    1                 1  1        2                 2  2              2   |             
      Hypertrophy                          |                                                             1            |             
      Necrosis                             | 2                                                                        |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1     1  1  2  1  1        1        1        2  2                 2|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3     4  3           2     2           3  3  3  2  3         |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | 2           1                             3                 2        2   |             
      Pars Distalis, Hyperplasia           | 2           2                             2        2  2     3            |             
      Pars Intermedia, Cyst                |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                            2                       1     2               |             
      Follicle, Cyst                       |          2                                2                              |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      2                                                   |             

                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2     2                                                |             
      Inflammation, Chronic Active         | 1  1  2  2  2  1  2  3  2  2  1  2  2  2  1  1  2  2  2  2  2  3  2  2  1|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Multilocular                    |       4                 2  3  2  2                                       |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5|             
                             DAY ON TEST   | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4|             
                                           | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         | 2  3  2  2  2  2  2  2        3  2  2  2  1  2  3  2  1  2  4  3  2  2  2|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        4                                 |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     |                                                    2  3     2  2         |             
      Arteriole, Necrosis, Fibrinoid       |                                                    2  3     2  2         |             
      Bilateral, Germinal Epithelium,      |                                                                          |             
          Atrophy                          |                                                       4                  |             
      Germinal Epithelium, Atrophy         |                                           4     4           4  3         |             
      Interstitial Cell, Hyperplasia       |    1  1                                   1     1                 1      |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                                             |             
      Hyperplasia                          | 4     3           3  4        4  4     3  4     4     3  3  2  4        4|             

                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +           +  +  +  +        +  +  +  +  +        +  +  +     +|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |    1  1  1           1  2     1        1  1  1  1  1        1  1  1     1|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             3                                      2                     |             
      Hematopoietic Cell Proliferation     |                                                                3         |             
      Necrosis                             |                                                                          |             
      Red Pulp, Depletion Cellular         | 2                                                                        |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                         3                        |             
      Hyperplasia, Cystic                  | 1  3  2  2     3  2  2  1  1  4     2     2  2  2  2  2  2  3     1  2  2|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                X         |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Callus                               |                                                                          |             
      Fibrous Osteodystrophy               |             3     4  4           3                 4     4  2  4         |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5|             
                             DAY ON TEST   | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4|             
                                           | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           | 3                                                                        |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                               +                                          |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                3         |             
      Inflammation, Chronic Active         |                1                                                         |             
      Inflammation, Granulomatous          |    1                                                        1            |             
      Inflammation, Suppurative            | 3                                                                        |             
      Mineralization                       |             3     2                                                      |             
      Alveolar Epithelium, Hyperplasia     |                            3                                             |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                      1           1        1                             1|             
      Interstitium, Mineralization         |                                                          3     2         |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         2        3              2        3           2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                  3              3  2     3           2   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                         2                                4           2   |             
      Vein, Turbinate, Septum, Thrombosis  |                            4                                             |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Lens, Cataract                       |                                           4                              |             
      Retina, Atrophy                      |                                           4                              |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3           3     2  3           2                             3         |             
      Hydronephrosis                       |                                                                          |             
      Mineralization                       |                   2                                      2     3         |             
      Nephropathy, Chronic                 | 2  2  3  3  4  2  4  4  2  3  3  4  3  3  3  2  2  4  4  4  3  4  2  2  2|             
      Pigmentation, Hemosiderin            | 3     1  1     1  1     1  2  2  1  1  1  3  1  1  1  1  1  1  1  1  1  2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        3                                 |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Transitional Epithelium, Hyperplasia |                   2                                                      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7|            |
                             DAY ON TEST   | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0|            |
                                           | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X                                   X                           |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X                                             |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |             4                                                           3|      2  3.5|
      Ulcer                                |             4                                                            |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                            X                                             |      3     |
      Clear Cell Focus                     |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           | X        X                          X     X              X           X   |      9     |
      Inflammation, Chronic                | 1     1     1  1  1  1                          1  1     1  2            |     20  1.1|
      Mineralization                       |                                                          1               |      1  1.0|
      Vacuolization Cytoplasmic            | 2     3  1        1              3        1  1  1  1  1        1     2  1|     27  1.5|
      Bile Duct, Hyperplasia               | 1     2  2  1  1  2  1  3  3  2  3  2  3  1  1  1  2  1  1  2  2  2  1  2|     47  1.7|
      Hepatocyte, Degeneration, Cystic     |                            2                                             |      8  1.3|
      Hepatocyte, Necrosis                 |                                                                          |      1  1.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration                     |                                  3                                       |      2  3.0|
      Hepatocyte, Centrilobular, Necrosis  |                                           4                              |      2  3.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                       +     +           +|   8        |
      Inflammation, Chronic Active         |                                                                         3|      1  3.0|
      Fat, Necrosis                        |                               4                       4     4            |      7  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                  1           1                       1  1|     11  1.4|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Cyst                           |                                           2                              |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |       3        3                                3                        |      6  3.0|
      Inflammation, Chronic Active         |       2     2  2  3              3        4     3     3              3  2|     15  2.5|
      Mineralization                       |                                                                          |      4  2.8|
      Perforation                          |       X                                   X                             X|      4     |
      Epithelium, Hyperplasia              |       3     3  2  3              3        4     2     3              2  3|     18  2.8|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7|            |
                             DAY ON TEST   | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0|            |
                                           | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Ulcer                    |       4     4  4  4              4        4     4     4              4   |     13  3.8|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                         1              2                                 |      7  2.3|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                        2                                 |      1  2.0|
      Aorta, Mineralization                |                         3                                                |      6  3.0|
      Pulmonary Artery, Mineralization     |                                                                          |      4  3.3|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 1  1     2        2  1  2  2  2  2     2  3  2     1  2  2  2  2  1  1   |     37  2.0|
      Inflammation, Suppurative            |                                        2                                 |      1  2.0|
      Mineralization                       |                                           1                              |      5  2.2|
      Atrium, Thrombosis                   |             4                    3        2                              |      6  3.3|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                           2  2                           |      3  2.0|
      Degeneration, Fatty                  | 1     1        1  2  1  1     1  2  1  2  1  2  1  1  2     1  1     2  2|     36  1.4|
      Hyperplasia                          |                                  2  2  2              2        2        2|     13  1.8|
      Hypertrophy                          |                                                          1               |      2  1.0|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1           1  2     1     2  3  2     2                    2|     20  1.6|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |             2           3                 2                             2|     14  2.6|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  | 2     1  2        1           2  3                 1  2           1  2  2|     16  1.8|
      Pars Distalis, Hyperplasia           |                            1  2     2     2        1              2     3|     13  2.0|
      Pars Intermedia, Cyst                | 2                                                                        |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                            2           1     1                           |      6  1.5|
      Follicle, Cyst                       |                                                                          |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7|            |
                             DAY ON TEST   | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0|            |
                                           | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                   +      |   1        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                                                        |      3  2.0|
      Inflammation, Chronic Active         | 2     2  1  2  2  2  2  2     2  2  2  3  1  2  2  2  3  1  2  2     2  1|     47  1.9|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Multilocular                    |          2  3           2                                1               |      9  2.3|
      Inflammation, Chronic Active         | 2  2  1  3     2  3  2  2  2  1  2  2  3  3  2  2  2  3     2  1  3  1  2|     46  2.1|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arteriole, Inflammation, Chronic     |                   2     2                    2        2                 1|      9  2.0|
      Arteriole, Necrosis, Fibrinoid       |                   2     2                    2        2                 1|      9  2.0|
      Bilateral, Germinal Epithelium,      |                                                                          |            |
          Atrophy                          |                                                                          |      1  4.0|
      Germinal Epithelium, Atrophy         |                         4              3           4  4  4              4|     10  3.8|
      Interstitial Cell, Hyperplasia       |                         1     1     1  1  1        1        1            |     12  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |             4           4  4  4  4        4        3                    3|     22  3.6|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +     +  +     +  +  +  +  +  +        +  +     +  +  +     +  +|  35        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 2     1  1     1  1     2        1              1  1     1  2  1     1  1|     29  1.1|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Ectasia                              |                                  3                                       |      1  3.0|
      Infiltration Cellular, Histiocyte    |             3                                                            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            2  2                          3           1   |      6  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Necrosis                             |                                  2                                       |      1  2.0|
      Red Pulp, Depletion Cellular         |                                           4                              |      2  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7|            |
                             DAY ON TEST   | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0|            |
                                           | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      2  3.0|
      Hyperplasia, Cystic                  |       3  3     2  3  3  2        3           2  3     2  2  3  2     2  2|     36  2.2|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Prepuce, Inflammation, Chronic Active|                                                                   3      |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Callus                               |       4                                                                  |      1  4.0|
      Fibrous Osteodystrophy               |             3           2                                                |     10  3.3|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                  +              +                        |   3        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +              +                        |   3        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                       1                  |      1  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                       1                  |      2  1.0|
      Inflammation, Granulomatous          |                                                                          |      2  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   1                                   1           2      |      7  1.1|
      Interstitium, Mineralization         |                                                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                            2                          2     3        3   |      9  2.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                  2              3                        |      2  2.5|
      Respiratory Epithelium, Hyperplasia  |                            3                          3     3        3   |      9  2.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      3  2.7|
      Vein, Turbinate, Septum, Thrombosis  |                                           4                              |      2  4.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7|            |
                             DAY ON TEST   | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0|            |
                                           | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                +         |   2        |
      Lens, Cataract                       |                                                                3         |      2  3.5|
      Retina, Atrophy                      |                                                                4         |      2  4.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                    +                     |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             2                    3                                       |      8  2.6|
      Hydronephrosis                       |                                                                   2      |      1  2.0|
      Mineralization                       |                                                                          |      3  2.3|
      Nephropathy, Chronic                 | 2     3  2  4  1  3  1  4  3  1  3  2  4  4  3  1  2  3  3  2  4  2  4  4|     49  2.8|
      Pigmentation, Hemosiderin            |       1     1  1  1     1  1  1  3  1  1  1  1  1  1  1  1  1  1  1  2  1|     43  1.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                   3      |      2  2.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4|             
                             DAY ON TEST   | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4|             
                                           | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    50 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                             X                             X            |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               X     X  X           X                     |             
      Clear Cell Focus                     |                         X                          X                     |             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X     X                 X                       X                     |             
      Inflammation, Chronic                |          1        1  2  2  1     2  1  1  1        1        1     1  1  1|             
      Vacuolization Cytoplasmic            | 3     3  2  2  1  3     1  2  2  1  1  1  2        2        1  1  1  1   |             
      Bile Duct, Hyperplasia               |    2  1  2  2  2  1  2  2  2  2  2  2  2  1  1  2  2  2  1  2  1  2  2  1|             
      Hepatocyte, Degeneration, Cystic     |       2           1                             2  1                     |             
      Hepatocyte, Necrosis                 |    2                                                     2               |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration                     |    2                                                                     |             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                +                                         +     +     +   |             
      Accessory Spleen                     |                                                                          |             
      Inflammation, Chronic Active         |                3                                                         |             
      Fat, Necrosis                        |                                                          4     4         |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Hyperplasia                |                                                                          |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Pharyngeal, Hyperplasia, Squamous    |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2  1  1     1        2     1        1     2  1        2  2  1        4  2|             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2        3  2                                             |             
      Inflammation, Chronic Active         |       3     2  3           3                                             |             
      Mineralization                       |                                                                          |             
      Perforation                          |             X                                                            |             
      Epithelium, Hyperplasia              |       3  2  3  3           3  3        2                                 |             
      Epithelium, Ulcer                    |       4     4  4                                                         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               2                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4|             
                             DAY ON TEST   | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4|             
                                           | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    50 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  1  2  2  2  2  2  2  1  2     1  1     2  2  1  2  1  2     1  1  2   |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                       1                  |             
      Degeneration, Cystic                 |                               2              2           1               |             
      Degeneration, Fatty                  | 2  1  2  1  1  2  1  1     2  2  2     2  2  2  2     2  2  1     2  2   |             
      Hyperplasia                          |       2     2     2        2  2           1  1  1  1  2  2  1     2  2   |             
      Hypertrophy                          | 2                 2                                      1               |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                             1     2  1     1           2   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
      Hyperplasia                          | 2                          2  3           2     2                        |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hematoidin             |                            3                                             |             
      Pars Distalis, Cyst                  |       2                    1        2                                    |             
      Pars Distalis, Hyperplasia           |       2                             2              2           2         |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1     1           1     1        1     1                           |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Coagulating Gland                       |    +                                            +        +               |             
      Inflammation, Chronic Active         |                                                          2               |             
      Inflammation, Suppurative            |    3                                            4                        |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  1  3  2  1  2     2|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Multilocular                    | 2        2        2                 1  2                                 |             
      Inflammation, Chronic Active         | 4  4  2  2  2  2  2  2  2  2  2  2  1  2  2  2  3  2  3  4  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4|             
                             DAY ON TEST   | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4|             
                                           | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    50 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     | 1     1           2           2           2           2                  |             
      Arteriole, Necrosis, Fibrinoid       |       1           2           2           2           2                  |             
      Germinal Epithelium, Atrophy         | 4     4                 2     4           4                    2         |             
      Interstitial Cell, Hyperplasia       |                1  1                          1           1               |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  4  4        4              4           3     4        4               |             

                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +        +           +  +  +     +  +  +  +     +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                           2                              |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |    1     1  1  1  1  1        1              1  1     1  1  1  1     1  1|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                  3                                       |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                          3               |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 3                          2  3                                          |             
      Hematopoietic Cell Proliferation     | 3                                                        3               |             
      Hyperplasia                          | 3                                                                        |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    4                     |             
      Hyperplasia, Cystic                  |    1     2  2  1  2  2  1  2  2  2  1  2  3  3  2  1  4  2  2     3  2  2|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  4                                       |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  | 2        1  2  2              2     2  2     2  2  2     1  1  1     1   |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     | 2        1  1  1  1  1  1  1  2  1  1  2  1  2  1  2  2     1  2  1  2  1|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Parakeratosis                   | 1           1                          1                                 |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |                                                                          |             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         | 2           1  1  1  1  1  1  2  1  2  2  1  2  1  2  2  1  1  2     2  1|             
      Skin, Site of Application, Hemorrhage|                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4|             
                             DAY ON TEST   | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4|             
                                           | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    50 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 2     4                       2                 2                        |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    2                                                                     |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                     1                                    |             
      Alveolar Epithelium, Hyperplasia     |                                                                      3   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          1  1     1              1  1  1     1                    1      |             
      Interstitium, Mineralization         |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  2     2  2                       1      |             
      Inflammation, Suppurative            |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2                                               2                     |             
      Respiratory Epithelium, Hyperplasia  |                                  3     3  2                       2      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                  2                                       |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
      Lens, Cataract                       |                                                                      3   |             
      Retina, Atrophy                      |                                                                      4   |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                  +                                       |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                          2               |             
      Cyst                                 |       3                             2           3                    2   |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 4  1  4  2  3  2  2  2  2  3  4  2  2  2  4  2  3  3  3  3  2  1  2  2  2|             
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  1  2  1  2  1  1  1     1  1  1  1     1  1  1|             
      Renal Tubule, Hyperplasia            |                                              2                           |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2|            |
                                           | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    50 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X  X           X     X                                    |      5     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X                 X                           |      5     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X     X     X                       X  X  X           X        X  X|     13     |
      Clear Cell Focus                     |       X     X                             X                    X         |      6     |
      Eosinophilic Focus                   |             X                                                            |      1     |
      Fibrosis                             |                                                             1            |      1  1.0|
      Hepatodiaphragmatic Nodule           | X           X  X                          X                       X      |      9     |
      Inflammation, Chronic                | 1  1        2        1  1  1     1           1                 1  1     1|     25  1.2|
      Vacuolization Cytoplasmic            | 1  1  1  2  2  1  2  2  1  2     1        1  2  1  3  2     2           1|     36  1.6|
      Bile Duct, Hyperplasia               | 1  1  1  2  2  2  1  2  2  1  3  1  3  1  1  1     1  1  2  1  1  2  1  1|     48  1.6|
      Hepatocyte, Degeneration, Cystic     |                                        1     1  1              1         |      8  1.3|
      Hepatocyte, Necrosis                 |                                           1                              |      3  1.7|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration                     |                                                                          |      1  2.0|
      Hepatocyte, Centrilobular, Necrosis  |                3                                                         |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                          +              +            |   7        |
      Accessory Spleen                     |                                                             X            |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                              4                           |      3  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                           +                       +      |   2        |
      Gingival, Hyperplasia                |                                           3                              |      1  3.0|
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                           3                              |      1  3.0|
      Pharyngeal, Hyperplasia, Squamous    |                                                                   3      |      1  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                   2     1        1     3  1           2              1  2|     22  1.6|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                    3                    4|      5  2.8|
      Inflammation, Chronic Active         |                                        4           3  2                 3|      8  2.9|
      Mineralization                       |                                                 1           3            |      2  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2|            |
                                           | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    50 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Perforation                          |                                                       X                  |      2     |
      Epithelium, Hyperplasia              |          3        3                    3           3  3  2     3  2     3|     16  2.8|
      Epithelium, Ulcer                    |                                        4           4  4                 4|      7  4.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                              1  3        3  2  2         |      6  2.2|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                                                 3        2  2  3         |      4  2.5|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 1  2  2  2     2  2  1  2  2  1  2     2  2  2  3  1  1  2  4  3     2  2|     43  1.8|
      Mineralization                       |                                                 3           3  1         |      3  2.3|
      Atrium, Thrombosis                   |                                                                4         |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                1         |      2  1.0|
      Degeneration, Cystic                 |                   2                                                      |      4  1.8|
      Degeneration, Fatty                  | 1  1     1  1  1  2  1  1  1  2  1  1  2  1     2  2  2  2  1     3      |     40  1.6|
      Hyperplasia                          |                   2        1           1     2  2        1  2            |     21  1.6|
      Hypertrophy                          |                   2                       1           2                  |      6  1.7|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2     2  1  1                 1  2     2  1        1  2  2     1  2|     19  1.5|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |       2           3                    2  2  3  3        3  3  3     2   |     15  2.5|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation, Hematoidin             |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                        2     1  2           3            |      7  1.9|
      Pars Distalis, Hyperplasia           |    2                                2  2     2              2           3|     10  2.1|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1                             1  1     2           1                  |     11  1.1|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                   +                                                      |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   3        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2|            |
                                           | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    50 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 2                        |      1  2.0|
      Inflammation, Chronic Active         | 2  2  2  2  2  2           2  2  2  2  2  2  2  2  2  2  1  3  3  2  3  2|     46  2.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Multilocular                    |                            1     2                             1         |      8  1.6|
      Inflammation, Chronic Active         | 3  2  3  2  2  2           2  2  2  2  1  2  4  2  3  2  2  4  2  2  4  2|     47  2.3|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arteriole, Inflammation, Chronic     |       2     2                                         1        2     2   |     11  1.7|
      Arteriole, Necrosis, Fibrinoid       |       2     2                                         1        2     2   |     10  1.8|
      Germinal Epithelium, Atrophy         |       4     4     4        4           2        4  4           4     4   |     15  3.6|
      Interstitial Cell, Hyperplasia       |    1  1                 1     1     1  1        1                 1      |     12  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    4              3           4  3  4  4  3  3  4  3     4  4  4     2   |     22  3.6|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +  +  +  +  +  +  +  +  +  +                 +  +     +      |  30        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |             1  1  2  1  1  1     1     1                 1  2     2      |     26  1.1|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                            3                                             |      2  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                   3     3|      5  2.8|
      Hematopoietic Cell Proliferation     |                                                                2         |      3  2.7|
      Hyperplasia                          |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  45        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |       4                                            4     4  4  4         |      6  4.0|
      Hyperplasia, Cystic                  | 2     3  3  2  2  3     2  3  3  3  2  1  2  2  3  3  3  3  3     2  2  2|     44  2.2|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |    4                                                                     |      2  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2|            |
                                           | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    50 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  | 1  1  1  1  1  1  2     1  2     1  1  1  1  2  1  1  1  1  2  2     1  2|     36  1.4|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 1  2  1  2  2  2  2  2  1  2  1  2  2  2  1  2  1  1  2  1  1  2     2  2|     46  1.5|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Parakeratosis                   |                   2        1           1  2  1     1                     |      9  1.2|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           |                                                    2                     |      1  2.0|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         | 1  2  1  2  2  1  2  2  1  2  1  2  2  2  1  2  1  1  2  1  1  1     2  2|     45  1.5|
      Skin, Site of Application, Hemorrhage|                                           4                              |      1  4.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic Active     |                                                    1                     |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                   2                    3     2  4        4  4  4     2   |     12  2.9|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            4                                             |      1  4.0|
      Inflammation, Chronic Active         |                            1     2              3     1  2  3  3         |      8  2.0|
      Alveolar Epithelium, Hyperplasia     |       1        4                                                  2      |      4  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                         1  1                 1     1  1                  |     13  1.0|
      Interstitium, Mineralization         |                                                 3        2  3  3         |      4  2.8|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 2                          2           3                                 |      7  2.0|
      Inflammation, Suppurative            |                                                                   3      |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                         2  3                                             |      4  2.3|
      Respiratory Epithelium, Hyperplasia  | 2                          2           3                                 |      7  2.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2                                                                        |      2  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2|            |
                                           | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    50 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                    +                        |   3        |
      Cornea, Inflammation, Chronic Active |                                                 2                        |      1  2.0|
      Cornea, Mineralization               |                                                 3                        |      1  3.0|
      Lens, Cataract                       |                            3                                             |      2  3.0|
      Retina, Atrophy                      |                            4                                             |      2  4.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   2        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  2.0|
      Cyst                                 |                   2                    2     3              3  3         |      9  2.6|
      Mineralization                       |                                           2     2        1               |      3  1.7|
      Nephropathy, Chronic                 | 1  1  3  3  2  3  4  1  2  2  2  2  2  4  4  4  4  3  3  4  4  4  2  3  4|     50  2.7|
      Pigmentation, Hemosiderin            | 1  1  1     1  1  1     1  1  1  1  1     1  1  1     1  1  1  1  1  1  1|     44  1.0|
      Renal Tubule, Hyperplasia            |                                           2                              |      2  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Gross Observation           |                                                          X               |      1     |
      Inflammation, Chronic Active         |                                        2                                 |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2|             
                                           | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Ulcer                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               X                                      X   |             
      Clear Cell Focus                     |                                                          X               |             
      Hepatodiaphragmatic Nodule           |                      X                 X              X              X   |             
      Inflammation, Chronic                |       1        1  1  2  1     1        1        1           1     2  2   |             
      Vacuolization Cytoplasmic            | 3     2        1  2  1  1     1  1     2           2  1  2  2     2  1   |             
      Bile Duct, Hyperplasia               | 2  2  1  2  2  1  1  2  2  2  2  2  1  1  3  1  1  3  1  2  1  1  2  2  2|             
      Hepatocyte, Degeneration, Cystic     |             1                             1                              |             
      Hepatocyte, Necrosis                 |                                                       2                  |             
      Portal Vein, Thrombosis              | 2                                                                        |             

                                            __________________________________________________________________________|             
   Mesentery                               |             +                          +                                 |             
      Fat, Necrosis                        |             4                          4                                 |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1  1  1     2  1        1                 1  1  1     1                 2|             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    1                    2                                   3  2         |             
      Foreign Body                         |                                                                X         |             
      Inflammation, Chronic Active         | 3     3  3  3                                3        3     3  3         |             
      Mineralization                       |                                                                          |             
      Perforation                          |       X                                      X              X            |             
      Epithelium, Hyperplasia              | 3     3  3  3           2                    3        2     3  3         |             
      Epithelium, Ulcer                    | 4     4  4                                   4        4     4  4         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       3                                                     3            |             
      Mineralization                       |                                                                          |             
      Epithelium, Erosion                  | 2                          3                                             |             
      Epithelium, Ulcer                    | 2     4                                                     4            |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2|             
                                           | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
      Pulmonary Artery, Mineralization     |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  2  2  1  1  2  2  2  2  2  2  2  2  2  2  2     2     2  1  2  2|             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   | 3                                                                        |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Atypia Cellular                      |                                                          1               |             
      Degeneration, Cystic                 |                                              2              1            |             
      Degeneration, Fatty                  | 2  1  2  2     1  1  1  1              1  1  2  1        1  1  2  1  1   |             
      Hyperplasia                          |       1  2        2        2        1  2  1  2                 1  1  1  2|             
      Hypertrophy                          | 3  2                                                                     |             
      Necrosis                             |                                                    2                     |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     2                    2              2           1  1            |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M|             
      Hyperplasia                          |             2                 3                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |       2                                                                  |             
      Pars Distalis, Hyperplasia           |             2                 3           2                              |             
      Pars Intermedia, Cyst                |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1        2                                                  1           1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                         2                           |             
      Inflammation, Chronic Active         | 2  2  2  2  2     1  2  2  2  1     2  2  2  2  1  3  2  2  3  2  1  2  2|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Multilocular                    |             2     2                                3                     |             
      Inflammation, Chronic Active         | 2  4  2  2  2  2  2  2  2  3  4  1  2  2  2  3  2     1     2  3  2  2  2|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     |    2     2                    3              2                       2   |             
      Arteriole, Necrosis, Fibrinoid       |    2     2                    3              2                       2   |             
      Bilateral, Germinal Epithelium,      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2|             
                                           | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Atrophy                          |                                                                          |             
      Germinal Epithelium, Atrophy         |    4     3                    4              4        3     4            |             
      Interstitial Cell, Hyperplasia       | 1                                   1                 1           1  1  2|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4     3     4                             4     3     3              3   |             

                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +        +  +  +|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      | 1  1     1  1     1  1  2  2     1  1  3     1  2        1        1  1  1|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             3                                                            |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Red Pulp, Depletion Cellular         |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               4        4     3                           |             
      Hyperplasia, Cystic                  | 2  2  2  2     3  4  2  3  2  3  1  2  2  1  3     1  2  3  2  3  2  2  2|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Hyperkeratosis            |                                        4                                 |             
      Epidermis, Hyperplasia               |                                        4                                 |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  | 2  2  1  2  2  1  1  2  1  2  2  1  2  2  2  2  3     2  2  2  3     2  2|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     | 2  2  1  2  3  2  3  3  1  3  2  2  2  3  3  3  2  2  3  2  3  3  3  3  2|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Parakeratosis                   | 2  2  1  1  2     1  2     2           2  2  2  2     2     2  2         |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |                                                                1         |             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         | 2  2  1  2  2  2  3  3  1  2  2  2  2  3  3  3  2  2  3  2  2  2  3  3  2|             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                2         |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |             4                 3                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2|             
                                           | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                           2                              |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1  1  1        1  1  1           1                       1        1|             
      Interstitium, Mineralization         |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       1     4                             1                              |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2                                                               |             
      Respiratory Epithelium, Hyperplasia  |       2     4                                                            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |             2                                                            |             
      Vein, Turbinate, Septum, Thrombosis  |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                            +        +           +  +     +              +|             
      Lens, Cataract                       |                            4        4           3  4     4              4|             
      Retina, Atrophy                      |                            4        4           4  4     4              4|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Cyst                                 |          2  2                                3                           |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 |    3  3  3  4  2  2  2  2  2  4  2  3  3  3  4  2  2  2  3  4  4  2  3  2|             
      Pigmentation, Hemosiderin            | 3  1  1  1  1  1  1  2  1  1  2  1  1  2  3  1  1  1  1  1  1  1  1  1  1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                               3                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2|            |
                                           | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    100                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                    X                     |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Ulcer                    |                                                          4               |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                      X                                                   |      3     |
      Clear Cell Focus                     |                      X                                                   |      2     |
      Hepatodiaphragmatic Nodule           |                      X                             X        X        X   |      8     |
      Inflammation, Chronic                |    1  1              1  1  1        2     2        1  3     1  1     1  2|     24  1.3|
      Vacuolization Cytoplasmic            |    3     1  3     2  1  1  3  1  3  2     2  3  2  2  3     2     2     1|     33  1.8|
      Bile Duct, Hyperplasia               | 2  1  1  1  2  2  2  2  2  2  2  2  2  3  1  2  1  2  2  3  1  1  2  1  2|     50  1.7|
      Hepatocyte, Degeneration, Cystic     |                                                       2                  |      3  1.3|
      Hepatocyte, Necrosis                 |                                                                          |      1  2.0|
      Portal Vein, Thrombosis              |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +           +     +     +         |   6        |
      Fat, Necrosis                        |                                        4           4           4         |      5  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                   +                 +                                    |   2        |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1              1  1  3  4  2  1        1  2  1  2           2        1  2|     25  1.5|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |       3     3              2                                   3         |      8  2.4|
      Foreign Body                         |                                                                          |      1     |
      Inflammation, Chronic Active         |             3     4                    3  2              2        3      |     14  2.9|
      Mineralization                       |                                     1                 3                  |      2  2.0|
      Perforation                          |                   X                                                      |      4     |
      Epithelium, Hyperplasia              |       3     3     3        2           3  1              2     2  4      |     18  2.7|
      Epithelium, Ulcer                    |             4     4                    4  3              4        4      |     13  3.9|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Mineralization                       |                                     3           2     3           2      |      4  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2|            |
                                           | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    100                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Erosion                  |                                                                          |      2  2.5|
      Epithelium, Ulcer                    |                                                                          |      3  3.3|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                                     3           3     3           3      |      4  3.0|
      Pulmonary Artery, Mineralization     |                                                 3                 3      |      2  3.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |          2  2  1  2  2     1  2  2  3     2  2  3  1  3  1  2     3  2  2|     42  1.9|
      Mineralization                       |                                     3           2     3           1      |      4  2.3|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |    2                                                                     |      1  2.0|
      Atypia Cellular                      |                                                                          |      1  1.0|
      Degeneration, Cystic                 |                                           2                              |      3  1.7|
      Degeneration, Fatty                  |    2  1  1  2  1  1  2  1  2  1  1  1     1  2  2  1  1  2     1  2     1|     38  1.3|
      Hyperplasia                          |    2     2  2        2  1  2  1  2           2        2           2     1|     24  1.6|
      Hypertrophy                          |                2                                         2        2      |      5  2.2|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1                    2                 2  2  2  2  1  2           2  1   |     16  1.7|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |             2              2        3           3     4           3      |      8  2.8|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Pars Distalis, Cyst                  |                                                       3                 2|      3  2.3|
      Pars Distalis, Hyperplasia           | 2              2              2     2     2           3           2  3  3|     12  2.3|
      Pars Intermedia, Cyst                |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1           1        1  1                 1              1              2|     11  1.2|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2|            |
                                           | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    100                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                      1   |      3  1.7|
      Inflammation, Chronic Active         | 2  2  1     2  2     2  1  2  2  2  2  2  2  1  2  2  4  2  1  2  2  2  2|     46  1.9|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Multilocular                    |                      3                                                   |      4  2.5|
      Inflammation, Chronic Active         | 2  2  2     2  2  2  2  2  2  2  2  1  3  2     4  2  3  2  2  2  2  2  2|     46  2.2|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arteriole, Inflammation, Chronic     |    2                 2     2     2           2        2           2  2   |     13  2.1|
      Arteriole, Necrosis, Fibrinoid       |    2                 2     2     2           2        2           2  2   |     13  2.1|
      Bilateral, Germinal Epithelium,      |                                                                          |            |
          Atrophy                          |                                                 4                        |      1  4.0|
      Germinal Epithelium, Atrophy         | 4  2        2                          4  3        2  4        2  4  4   |     16  3.3|
      Interstitial Cell, Hyperplasia       |    1     1     1     1                    1        1  1                  |     13  1.1|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                4                    3  4        4     4  4     3  4     3|     16  3.6|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +     +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|  37        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 1              1     1  1  1     1        1  1  1  2  1     1  1  1  1  1|     33  1.2|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |             2                                                            |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                       3           3      |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                         4|      1  4.0|
      Red Pulp, Depletion Cellular         |                                           2                              |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Ectopic Parathyroid Gland            |                                              2                           |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        2                                 |      4  3.3|
      Hyperplasia, Cystic                  | 2  2  1     2     3  2  3  2  1  4  2  2  2  2  3  2  2  3        2  1   |     43  2.2|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Hyperkeratosis            |                                                                          |      1  4.0|
      Epidermis, Hyperplasia               |                                                                          |      1  4.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2|            |
                                           | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    100                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Hyperkeratosis                  | 2  1  2  2  3  1  3  2  2  2  2  1  1  3  2  1  2  1  2  2  2  2  2  2  2|     48  1.9|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 3  2  3  3  3  3  3  2  2  2  2  2  1  3  1  3  2  2  2  3  2  2  3  2  3|     50  2.4|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Parakeratosis                   | 2     2  2  2  1  3     1              2        2        3     2  2     1|     28  1.9|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           |                                                                          |      1  1.0|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         | 2  2  3  3  3  3  2  2  2  2  2  2  1  2  1  2  2  2  1  3  2  2  1  2  3|     50  2.2|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic Active     |             2                                                            |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                     3           2     4           3      |      6  3.2|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           2                              |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 3                                                                 2      |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                            4                                             |      1  4.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |             1        1     1                                             |     12  1.0|
      Interstitium, Mineralization         |                                     3                 2                  |      2  2.5|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |          2  2  2  2           3                 2              2         |     10  2.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             3                             3                       3      |      4  2.8|
      Respiratory Epithelium, Hyperplasia  |          3  3  3  3           3                 2              3         |      9  2.9|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |             3                                                  2         |      3  2.3|
      Vein, Turbinate, Septum, Thrombosis  | 4                                               4                        |      2  4.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 55312-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 01/28/99  
Route: SKIN APPLICATION                                                                                           Time: 08:08:22  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7|            |
                             DAY ON TEST   | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2|            |
                                           | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    100                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                            +  +                                          |   8        |
      Lens, Cataract                       |                            4  4                                          |      8  3.9|
      Retina, Atrophy                      |                            4  4                                          |      8  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                          2               |      1  2.0|
      Cyst                                 |                      2     2                                      3     2|      7  2.3|
      Mineralization                       |                                                 3     3           2      |      3  2.7|
      Nephropathy, Chronic                 | 2  3  1  2  3  2  3  3  2  4  2  4  4  3  2  3  4  3  4  2  2  1  4  2  2|     49  2.7|
      Pigmentation, Hemosiderin            | 1  2  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  4  1  1  1  1  1|     50  1.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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