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TDMS Study 55312-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                         COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                      DATE: 01/28/99       
EXPERIMENT: 55312 TEST: 03                                                                                     TIME: 08:14:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55312B       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 68603-42-9      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        2 YEAR CHRONIC RATS                                                         
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                         COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                      DATE: 01/28/99     
EXPERIMENT: 55312 TEST: 03                                                                                     TIME: 08:14:33     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: N01-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55312B     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 68603-42-9    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hyperplasia
Adrenal Medulla                        Hyperplasia
Blood Vessel: Pulmonary Artery         Mineralization
Bone Marrow                            Hyperplasia
Heart: Atrium                          Thrombosis
Kidney                                 Pigmentation Hemosiderin
Liver                                  Basophilic Focus
                                       Vacuolization Cytoplasmic
Liver: Hepatocyte                      Degeneration Cystic
Lung                                   Inflammation Chronic
Mammary Gland                          Hyperplasia Cystic
Pancreas: Acinus                       Atrophy
Parathyroid Gland                      Hyperplasia
Pituitary Gland: Pars Distalis         Cyst
Prostate                               Cyst Multilocular
Skin: Epidermis, Skin, Site of Application
                                       Hyperkeratosis
                                       Hyperplasia
                                       Parakeratosis
Skin: Sebaceous Gland, Skin, Site of Application
                                       Hyperplasia
Spleen                                 Fibrosis
Stomach, Forestomach                   Inflammation Chronic
Stomach, Forestomach: Epithelium       Ulcer
Stomach, Glandular: Epithelium         Ulcer
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Hyperplasia
                                       Hypertrophy
Heart: Atrium                          Thrombosis
Kidney                                 Mineralization
Liver                                  Basophilic Focus
                                       Inflammation Chronic
Liver: Bile Duct                       Hyperplasia
Lung                                   Inflammation Chronic
Lung: Alveolus                         Infiltration Cellular Histiocyte
Pancreas: Acinus                       Atrophy
Parathyroid Gland                      Hyperplasia
Skin: Epidermis, Skin, Site of Application
                                       Hyperkeratosis
                                       Hyperplasia
                                       Parakeratosis
                                       Ulcer
Skin: Sebaceous Gland, Skin, Site of Application
                                       Hyperplasia
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                         COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                      DATE: 01/28/99     
EXPERIMENT: 55312 TEST: 03                                                                                     TIME: 08:14:33     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: N01-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55312B     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 68603-42-9    

Stomach, Forestomach                   Inflammation Chronic
Stomach, Forestomach: Epithelium       Hyperplasia
                                       Ulcer
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 1

Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.7%             2.9%          |  0.0%             2.7%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              620              621           |  ---              728 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.437          P=0.317          P=0.553       |  P=0.696          P=0.469          (e)             |
|POLY 3             |        P=0.427          P=0.270          P=0.527       |  P=0.698          P=0.475          (e)             |
|POLY 1.5           |        P=0.400          P=0.257          P=0.516       |  P=0.708          P=0.482          (e)             |
|POLY 6             |        P=0.467          P=0.289          P=0.543       |  P=0.691          P=0.471          (e)             |
|LOGISTIC REGRESSION|        P=0.389          P=0.277          P=0.505       |  (e)              P=0.469          (e)             |
|COCH-ARM / FISHERS |        P=0.360          P=0.247          P=0.500       |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        4/50 (8%)        3/50 (6%)     |  8/50 (16%)       6/50 (12%)       8/50 (16%)      |
|POLY-3 ADJUSTED (b)|        9.9%             11.6%            8.7%          |  18.3%            15.7%            22.2%           |
|TERMINAL (d)       |        1/8 (13%)        3/12 (25%)       1/11 (9%)     |  6/28 (21%)       4/24 (17%)       4/22 (18%)      |
|FIRST INCIDENCE    |        705              725              695           |  493              612              665             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.448N         P=0.587N         P=0.551N      |  P=0.365          P=0.516N         P=0.410         |
|POLY 3             |        P=0.513N         P=0.572          P=0.604N      |  P=0.409          P=0.497N         P=0.438         |
|POLY 1.5           |        P=0.539N         P=0.545          P=0.627N      |  P=0.455          P=0.464N         P=0.491         |
|POLY 6             |        P=0.478N         P=0.609          P=0.571N      |  P=0.379          P=0.518N         P=0.406         |
|LOGISTIC REGRESSION|        P=0.435N         P=0.604N         P=0.531N      |  P=0.399          P=0.467N         P=0.453         |
|COCH-ARM / FISHERS |        P=0.579          P=0.500          P=0.661N      |  P=0.556          P=0.387N         P=0.607N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 2

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Fatty                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        36/50 (72%)      40/50 (80%)      38/50 (76%)   |  22/50 (44%)      14/50 (28%)      16/50 (32%)     |
|POLY-3 ADJUSTED (b)|        78.4%            83.8%            80.7%         |  48.1%            35.8%            43.1%           |
|TERMINAL (d)       |        3/8 (38%)        7/12 (58%)       7/11 (64%)    |  11/28 (39%)      8/24 (33%)       9/22 (41%)      |
|FIRST INCIDENCE    |        334              380              329           |  585              533              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.268N         P=0.344N         P=0.293N      |  P=0.392N         P=0.218N         P=0.455N        |
|POLY 3             |        P=0.444          P=0.338          P=0.494       |  P=0.319N         P=0.174N         P=0.405N        |
|POLY 1.5           |        P=0.424          P=0.300          P=0.472       |  P=0.239N         P=0.132N         P=0.306N        |
|POLY 6             |        P=0.490          P=0.427          P=0.543       |  P=0.395N         P=0.220N         P=0.490N        |
|LOGISTIC REGRESSION|        P=0.300          P=0.190          P=0.341       |  P=0.302N         P=0.139N         P=0.355N        |
|COCH-ARM / FISHERS |        P=0.363          P=0.241          P=0.410       |  P=0.124N         P=0.072N         P=0.151N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        13/50 (26%)      21/50 (42%)      24/50 (48%)   |  22/50 (44%)      14/50 (28%)      11/50 (22%)     |
|POLY-3 ADJUSTED (b)|        38.6%            54.2%            58.6%         |  48.3%            36.5%            30.4%           |
|TERMINAL (d)       |        2/8 (25%)        8/12 (67%)       6/11 (55%)    |  12/28 (43%)      8/24 (33%)       8/22 (36%)      |
|FIRST INCIDENCE    |        458              534              485           |  585              677              620             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.144          P=0.351          P=0.169       |  P=0.087N         P=0.215N         P=0.110N        |
|POLY 3             |        P=0.051          P=0.123          P=0.056       |  P=0.053N         P=0.189N         P=0.075N        |
|POLY 1.5           |        P=0.030 *        P=0.099          P=0.033 *     |  P=0.031N*        P=0.139N         P=0.045N*       |
|POLY 6             |        P=0.113          P=0.173          P=0.117       |  P=0.085N         P=0.244N         P=0.115N        |
|LOGISTIC REGRESSION|        P=0.034 *        P=0.152          P=0.038 *     |  P=0.049N*        P=0.154N         P=0.061N        |
|COCH-ARM / FISHERS |        P=0.016 *        P=0.069          P=0.019 *     |  P=0.012N*        P=0.072N         P=0.016N*       |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 3

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        6/50 (12%)       5/50 (10%)    |  10/50 (20%)      3/50 (6%)        7/50 (14%)      |
|POLY-3 ADJUSTED (b)|        6.6%             16.8%            14.0%         |  22.8%            8.0%             19.1%           |
|TERMINAL (d)       |        2/8 (25%)        1/12 (8%)        1/11 (9%)     |  6/28 (21%)       3/24 (13%)       2/22 (9%)       |
|FIRST INCIDENCE    |        729 (T)          561              474           |  585              728 (T)          588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.318          P=0.283          P=0.364       |  P=0.399N         P=0.072N         P=0.500N        |
|POLY 3             |        P=0.276          P=0.186          P=0.284       |  P=0.322N         P=0.062N         P=0.446N        |
|POLY 1.5           |        P=0.237          P=0.164          P=0.255       |  P=0.291N         P=0.052N         P=0.400N        |
|POLY 6             |        P=0.340          P=0.226          P=0.332       |  P=0.343N         P=0.072N         P=0.475N        |
|LOGISTIC REGRESSION|        P=0.249          P=0.213          P=0.278       |  P=0.351N         P=0.060N         P=0.430N        |
|COCH-ARM / FISHERS |        P=0.187          P=0.134          P=0.218       |  P=0.231N         P=0.036N*        P=0.298N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        20/50 (40%)      19/50 (38%)      16/50 (32%)   |  1/50 (2%)        2/50 (4%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        57.6%            52.0%            44.4%         |  2.3%             5.2%             8.4%            |
|TERMINAL (d)       |        4/8 (50%)        9/12 (75%)       6/11 (55%)    |  1/28 (4%)        1/24 (4%)        1/22 (5%)       |
|FIRST INCIDENCE    |        540              575              593           |  728 (T)          562              665             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.058N         P=0.122N         P=0.081N      |  P=0.163          P=0.448          P=0.236         |
|POLY 3             |        P=0.141N         P=0.397N         P=0.170N      |  P=0.178          P=0.461          P=0.246         |
|POLY 1.5           |        P=0.168N         P=0.420N         P=0.198N      |  P=0.191          P=0.472          P=0.263         |
|POLY 6             |        P=0.122N         P=0.410N         P=0.155N      |  P=0.171          P=0.457          P=0.237         |
|LOGISTIC REGRESSION|        P=0.036N*        P=0.175N         P=0.058N      |  P=0.177          P=0.485          P=0.231         |
|COCH-ARM / FISHERS |        P=0.234N         P=0.500N         P=0.266N      |  P=0.222          P=0.500          P=0.309         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 4

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Aorta                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       4/50 (8%)        4/50 (8%)     |  0/50 (0%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        18.3%            11.3%            11.4%         |  0.0%             2.6%             2.8%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        563              575              656           |  ---              562              715             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.200N         P=0.244N         P=0.239N      |  P=0.283          P=0.472          P=0.457         |
|POLY 3             |        P=0.264N         P=0.318N         P=0.320N      |  P=0.300          P=0.478          P=0.464         |
|POLY 1.5           |        P=0.277N         P=0.332N         P=0.336N      |  P=0.309          P=0.484          P=0.475         |
|POLY 6             |        P=0.253N         P=0.308N         P=0.307N      |  P=0.294          P=0.475          P=0.458         |
|LOGISTIC REGRESSION|        P=0.252N         P=0.322N         P=0.328N      |  P=0.335          P=0.583          P=0.455         |
|COCH-ARM / FISHERS |        P=0.303N         P=0.370N         P=0.370N      |  P=0.331          P=0.500          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Pulmonary Artery                                                                                                   |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        12.6%            0.0%             5.8%          |  0.0%             0.0%             2.8%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        593              ---              674           |  ---              ---              715             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.164N         P=0.051N         P=0.250N      |  P=0.243          (e)              P=0.457         |
|POLY 3             |        P=0.209N         P=0.048N*        P=0.296N      |  P=0.275          (e)              P=0.464         |
|POLY 1.5           |        P=0.213N         P=0.052N         P=0.310N      |  P=0.273          (e)              P=0.475         |
|POLY 6             |        P=0.205N         P=0.045N*        P=0.283N      |  P=0.275          (e)              P=0.458         |
|LOGISTIC REGRESSION|        P=0.203N         P=0.061N         P=0.304N      |  P=0.240          (e)              P=0.455         |
|COCH-ARM / FISHERS |        P=0.222N         P=0.059N         P=0.339N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 5

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        10/50 (20%)      12/50 (24%)      6/50 (12%)    |  0/50 (0%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        30.4%            33.3%            17.1%         |  0.0%             5.2%             5.6%            |
|TERMINAL (d)       |        1/8 (13%)        4/12 (33%)       2/11 (18%)    |  0/28 (0%)        1/24 (4%)        1/22 (5%)       |
|FIRST INCIDENCE    |        593              575              656           |  ---              562              715             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.081N         P=0.463N         P=0.100N      |  P=0.131          P=0.208          P=0.191         |
|POLY 3             |        P=0.122N         P=0.500          P=0.150N      |  P=0.138          P=0.213          P=0.199         |
|POLY 1.5           |        P=0.141N         P=0.470          P=0.168N      |  P=0.149          P=0.219          P=0.210         |
|POLY 6             |        P=0.108N         P=0.524          P=0.137N      |  P=0.131          P=0.210          P=0.192         |
|LOGISTIC REGRESSION|        P=0.078N         P=0.597N         P=0.114N      |  P=0.147          P=0.244          P=0.187         |
|COCH-ARM / FISHERS |        P=0.185N         P=0.405          P=0.207N      |  P=0.176          P=0.247          P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  4.7%             5.3%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  1/28 (4%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  708              708              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.235N         P=0.641          P=0.295N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.238N         P=0.649          P=0.280N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.218N         P=0.662          P=0.266N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.253N         P=0.641          P=0.289N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.228N         P=0.641          P=0.288N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.176N         P=0.691N         P=0.247N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 6

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        22/50 (44%)      22/50 (44%)      16/50 (32%)   |  12/50 (24%)      14/50 (28%)      10/50 (20%)     |
|POLY-3 ADJUSTED (b)|        60.4%            55.8%            40.4%         |  27.0%            34.7%            27.4%           |
|TERMINAL (d)       |        4/8 (50%)        4/12 (33%)       2/11 (18%)    |  4/28 (14%)       8/24 (33%)       5/22 (23%)      |
|FIRST INCIDENCE    |        495              529              389           |  493              280              536             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.050N         P=0.202N         P=0.063N      |  P=0.477          P=0.272          P=0.542         |
|POLY 3             |        P=0.039N*        P=0.424N         P=0.052N      |  P=0.499          P=0.295          P=0.583         |
|POLY 1.5           |        P=0.063N         P=0.476N         P=0.080N      |  P=0.528N         P=0.328          P=0.548N        |
|POLY 6             |        P=0.023N*        P=0.363N         P=0.032N*     |  P=0.441          P=0.271          P=0.534         |
|LOGISTIC REGRESSION|        P=0.064N         P=0.354N         P=0.092N      |  P=0.493N         P=0.370          P=0.573N        |
|COCH-ARM / FISHERS |        P=0.131N         P=0.580N         P=0.151N      |  P=0.363N         P=0.410          P=0.405N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  4/49 (8%)        1/50 (2%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                                                        |  9.5%             2.7%             8.4%            |
|TERMINAL (d)       |                                                        |  3/28 (11%)       1/24 (4%)        3/22 (14%)      |
|FIRST INCIDENCE    |                                                        |  636              728 (T)          728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.524N         P=0.228N         P=0.628N        |
|POLY 3             |                                                        |  P=0.474N         P=0.214N         P=0.591N        |
|POLY 1.5           |                                                        |  P=0.451N         P=0.201N         P=0.559N        |
|POLY 6             |                                                        |  P=0.491N         P=0.223N         P=0.614N        |
|LOGISTIC REGRESSION|                                                        |  P=0.510N         P=0.216N         P=0.612N        |
|COCH-ARM / FISHERS |                                                        |  P=0.402N         P=0.175N         P=0.489N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 7

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  6/49 (12%)       6/50 (12%)       8/50 (16%)      |
|POLY-3 ADJUSTED (b)|                                                        |  14.4%            15.4%            21.1%           |
|TERMINAL (d)       |                                                        |  6/28 (21%)       3/24 (13%)       2/22 (9%)       |
|FIRST INCIDENCE    |                                                        |  728 (T)          225              308             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.207          P=0.524          P=0.247         |
|POLY 3             |                                                        |  P=0.265          P=0.571          P=0.311         |
|POLY 1.5           |                                                        |  P=0.286          P=0.589          P=0.335         |
|POLY 6             |                                                        |  P=0.258          P=0.564          P=0.304         |
|LOGISTIC REGRESSION|                                                        |  P=0.316          P=0.589          P=0.352         |
|COCH-ARM / FISHERS |                                                        |  P=0.344          P=0.606N         P=0.403         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland: Duct                                                                                                             |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  2/49 (4%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                                                        |  4.8%             2.6%             5.6%            |
|TERMINAL (d)       |                                                        |  2/28 (7%)        0/24 (0%)        2/22 (9%)       |
|FIRST INCIDENCE    |                                                        |  728 (T)          677              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.520          P=0.546N         P=0.607         |
|POLY 3             |                                                        |  P=0.573          P=0.534N         P=0.635         |
|POLY 1.5           |                                                        |  P=0.587          P=0.523N         P=0.656         |
|POLY 6             |                                                        |  P=0.564          P=0.541N         P=0.621         |
|LOGISTIC REGRESSION|                                                        |  P=0.534          P=0.544N         P=0.607         |
|COCH-ARM / FISHERS |                                                        |  P=0.603N         P=0.492N         P=0.684N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 8

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Coagulating Gland                                                                                                                |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/0 (0%)         2/3 (67%)        0/0 (0%)      |  0/0 (0%)         0/0 (0%)         0/0 (0%)        |
|POLY-3 ADJUSTED (b)|        0.0%             67.0%            0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/0 (0%)         1/1 (100%)       0/0 (0%)      |  0/0 (0%)         0/0 (0%)         0/0 (0%)        |
|FIRST INCIDENCE    |        ---              589              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.710N         P=0.625          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 6             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=1.000N         P=1.000          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/2 (100%)       2/3 (67%)        8/8 (100%)    |  5/6 (83%)        1/2 (50%)        4/5 (80%)       |
|POLY-3 ADJUSTED (b)|        100.0%           68.1%            100.0%        |  86.0%            58.3%            80.9%           |
|TERMINAL (d)       |        1/1 (100%)       1/1 (100%)       3/3 (100%)    |  1/1 (100%)       1/1 (100%)       2/2 (100%)      |
|FIRST INCIDENCE    |        668              670              552           |  618              728 (T)          387             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.080          P=0.681N         (e)           |  P=0.306N         P=0.092N         P=0.451N        |
|POLY 3             |        P=0.548          P=0.598N         (e)           |  P=0.563N         P=0.610N         P=0.716N        |
|POLY 1.5           |        P=0.535          P=0.587N         (e)           |  P=0.567N         P=0.554N         P=0.718N        |
|POLY 6             |        P=0.575          P=0.619N         (e)           |  P=0.553N         P=0.727N         P=0.715N        |
|LOGISTIC REGRESSION|        P=0.554          P=0.605N         (e)           |  P=0.532N         P=0.482N         P=0.699N        |
|COCH-ARM / FISHERS |        P=0.521          P=0.600N         (e)           |  P=0.577N         P=0.464N         P=0.727N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 9

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/2 (100%)       2/3 (67%)        8/8 (100%)    |  3/6 (50%)        1/2 (50%)        3/5 (60%)       |
|POLY-3 ADJUSTED (b)|        100.0%           68.1%            100.0%        |  51.8%            58.3%            73.2%           |
|TERMINAL (d)       |        1/1 (100%)       1/1 (100%)       3/3 (100%)    |  1/1 (100%)       1/1 (100%)       2/2 (100%)      |
|FIRST INCIDENCE    |        668              670              552           |  618              728 (T)          545             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.080          P=0.681N         (e)           |  P=0.419N         P=0.274N         P=0.570N        |
|POLY 3             |        P=0.548          P=0.598N         (e)           |  P=0.385          P=0.734          P=0.493         |
|POLY 1.5           |        P=0.535          P=0.587N         (e)           |  P=0.419          P=0.747          P=0.525         |
|POLY 6             |        P=0.575          P=0.619N         (e)           |  P=0.363          P=0.710          P=0.483         |
|LOGISTIC REGRESSION|        P=0.554          P=0.605N         (e)           |  P=0.429          P=0.791          P=0.579         |
|COCH-ARM / FISHERS |        P=0.521          P=0.600N         (e)           |  P=0.491          P=0.786N         P=0.608         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy Chronic                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        36/50 (72%)      43/50 (86%)      42/50 (84%)   |  22/50 (44%)      16/50 (32%)      14/50 (28%)     |
|POLY-3 ADJUSTED (b)|        82.2%            91.0%            90.6%         |  48.8%            38.7%            36.9%           |
|TERMINAL (d)       |        6/8 (75%)        10/12 (83%)      11/11 (100%)  |  14/28 (50%)      9/24 (38%)       8/22 (36%)      |
|FIRST INCIDENCE    |        110              380              421           |  522              280              377             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.399N         P=0.419N         P=0.420N      |  P=0.251N         P=0.352N         P=0.292N        |
|POLY 3             |        P=0.118          P=0.144          P=0.160       |  P=0.150N         P=0.230N         P=0.189N        |
|POLY 1.5           |        P=0.091          P=0.104          P=0.127       |  P=0.113N         P=0.206N         P=0.142N        |
|POLY 6             |        P=0.174          P=0.217          P=0.230       |  P=0.181N         P=0.242N         P=0.229N        |
|LOGISTIC REGRESSION|        P=0.131          P=0.100          P=0.169       |  P=0.107N         P=0.195N         P=0.164N        |
|COCH-ARM / FISHERS |        P=0.082          P=0.070          P=0.114       |  P=0.058N         P=0.151N         P=0.072N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 10

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       3/50 (6%)        4/50 (8%)     |  1/50 (2%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        15.6%            8.6%             11.4%         |  2.3%             0.0%             2.8%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  1/28 (4%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        593              708              656           |  728 (T)          ---              715             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.309N         P=0.224N         P=0.359N      |  P=0.617          P=0.531N         P=0.709         |
|POLY 3             |        P=0.382N         P=0.306N         P=0.440N      |  P=0.660          P=0.525N         P=0.719         |
|POLY 1.5           |        P=0.398N         P=0.322N         P=0.461N      |  P=0.663          P=0.518N         P=0.732         |
|POLY 6             |        P=0.364N         P=0.293N         P=0.415N      |  P=0.658          P=0.529N         P=0.711         |
|LOGISTIC REGRESSION|        P=0.344N         P=0.275N         P=0.433N      |  P=0.618          (e)              P=0.711         |
|COCH-ARM / FISHERS |        P=0.427N         P=0.357N         P=0.500N      |  P=0.669          P=0.500N         P=0.753N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       1/50 (2%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        19.0%            2.9%             2.9%          |  0.0%             2.7%             8.3%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        593              728              687           |  ---              708              672             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.011N*        P=0.025N*        P=0.035N*     |  P=0.042 *        P=0.473          P=0.086         |
|POLY 3             |        P=0.016N*        P=0.038N*        P=0.039N*     |  P=0.048 *        P=0.476          P=0.091         |
|POLY 1.5           |        P=0.018N*        P=0.044N*        P=0.045N*     |  P=0.051          P=0.482          P=0.098         |
|POLY 6             |        P=0.014N*        P=0.033N*        P=0.033N*     |  P=0.046 *        P=0.472          P=0.087         |
|LOGISTIC REGRESSION|        P=0.012N*        P=0.031N*        P=0.035N*     |  P=0.044 *        P=0.472          P=0.090         |
|COCH-ARM / FISHERS |        P=0.023N*        P=0.056N         P=0.056N      |  P=0.060          P=0.500          P=0.121         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 11

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.6%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        702              ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.078N         P=0.167N         P=0.222N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.094N         P=0.208N         P=0.210N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.094N         P=0.219N         P=0.220N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.094N         P=0.194N         P=0.197N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.065N         P=0.168N         P=0.177N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)     |  2/50 (4%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.9%          |  4.7%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  2/28 (7%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              687           |  728 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.329          (e)              P=0.596       |  P=0.122N         P=0.272N         P=0.292N        |
|POLY 3             |        P=0.292          (e)              P=0.526       |  P=0.112N         P=0.266N         P=0.279N        |
|POLY 1.5           |        P=0.283          (e)              P=0.516       |  P=0.106N         P=0.257N         P=0.266N        |
|POLY 6             |        P=0.305          (e)              P=0.541       |  P=0.116N         P=0.271N         P=0.288N        |
|LOGISTIC REGRESSION|        P=0.291          (e)              P=0.543       |  P=0.122N         (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.269          (e)              P=0.500       |  P=0.095N         P=0.247N         P=0.247N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 12

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        5/50 (10%)       1/50 (2%)     |  2/50 (4%)        5/50 (10%)       1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        6.5%             14.1%            2.9%          |  4.7%             13.3%            2.8%            |
|TERMINAL (d)       |        1/8 (13%)        2/12 (17%)       0/11 (0%)     |  1/28 (4%)        4/24 (17%)       0/22 (0%)       |
|FIRST INCIDENCE    |        556              621              593           |  717              722              715             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.287N         P=0.363          P=0.430N      |  P=0.527N         P=0.159          P=0.582N        |
|POLY 3             |        P=0.337N         P=0.272          P=0.458N      |  P=0.542N         P=0.167          P=0.562N        |
|POLY 1.5           |        P=0.365N         P=0.250          P=0.474N      |  P=0.502N         P=0.181          P=0.544N        |
|POLY 6             |        P=0.299N         P=0.307          P=0.435N      |  P=0.568N         P=0.158          P=0.575N        |
|LOGISTIC REGRESSION|        P=0.351N         P=0.290          P=0.486N      |  P=0.524N         P=0.154          P=0.581N        |
|COCH-ARM / FISHERS |        P=0.412N         P=0.218          P=0.500N      |  P=0.412N         P=0.218          P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        5/50 (10%)       0/50 (0%)     |  6/50 (12%)       4/50 (8%)        6/50 (12%)      |
|POLY-3 ADJUSTED (b)|        6.6%             14.1%            0.0%          |  14.0%            10.3%            16.1%           |
|TERMINAL (d)       |        2/8 (25%)        2/12 (17%)       0/11 (0%)     |  5/28 (18%)       1/24 (4%)        3/22 (14%)      |
|FIRST INCIDENCE    |        729 (T)          534              ---           |  698              562              314             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.146N         P=0.387          P=0.166N      |  P=0.416          P=0.463N         P=0.466         |
|POLY 3             |        P=0.174N         P=0.281          P=0.209N      |  P=0.482          P=0.434N         P=0.521         |
|POLY 1.5           |        P=0.197N         P=0.255          P=0.220N      |  P=0.506          P=0.418N         P=0.549         |
|POLY 6             |        P=0.144N         P=0.324          P=0.194N      |  P=0.472          P=0.436N         P=0.508         |
|LOGISTIC REGRESSION|        P=0.163N         P=0.318          (e)           |  P=0.505          P=0.442N         P=0.554         |
|COCH-ARM / FISHERS |        P=0.238N         P=0.218          P=0.247N      |  P=0.564          P=0.370N         P=0.620N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 13

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Accumulation, Hyaline Droplet                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)     |  2/50 (4%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.9%             2.9%          |  4.6%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              725              640           |  493              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.385          P=0.612          P=0.552       |  P=0.120N         P=0.267N         P=0.287N        |
|POLY 3             |        P=0.380          P=0.527          P=0.527       |  P=0.115N         P=0.271N         P=0.285N        |
|POLY 1.5           |        P=0.360          P=0.517          P=0.516       |  P=0.108N         P=0.260N         P=0.269N        |
|POLY 6             |        P=0.408          P=0.541          P=0.542       |  P=0.121N         P=0.279N         P=0.297N        |
|LOGISTIC REGRESSION|        P=0.368          P=0.587          P=0.516       |  P=0.061N         P=0.158N         P=0.150N        |
|COCH-ARM / FISHERS |        P=0.331          P=0.500          P=0.500       |  P=0.095N         P=0.247N         P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       9/50 (18%)       7/50 (14%)    |  2/50 (4%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        24.7%            25.5%            20.0%         |  4.6%             0.0%             2.8%            |
|TERMINAL (d)       |        0/8 (0%)         5/12 (42%)       4/11 (36%)    |  1/28 (4%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        521              617              626           |  613              ---              620             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.245N         P=0.428N         P=0.304N      |  P=0.424N         P=0.286N         P=0.576N        |
|POLY 3             |        P=0.372N         P=0.584          P=0.431N      |  P=0.400N         P=0.268N         P=0.562N        |
|POLY 1.5           |        P=0.396N         P=0.557          P=0.453N      |  P=0.387N         P=0.259N         P=0.544N        |
|POLY 6             |        P=0.349N         P=0.611          P=0.410N      |  P=0.408N         P=0.275N         P=0.574N        |
|LOGISTIC REGRESSION|        P=0.274N         P=0.536N         P=0.352N      |  P=0.365N         P=0.242N         P=0.503N        |
|COCH-ARM / FISHERS |        P=0.446N         P=0.500          P=0.500N      |  P=0.360N         P=0.247N         P=0.500N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 14

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        3/50 (6%)     |  50/50 (100%)     45/50 (90%)      47/50 (94%)     |
|POLY-3 ADJUSTED (b)|        9.5%             8.5%             8.6%          |  100.0%           90.3%            94.0%           |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  28/28 (100%)     20/24 (83%)      19/22 (86%)     |
|FIRST INCIDENCE    |        593              575              656           |  342              225              271             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.480N         P=0.560N         P=0.548N      |  P=0.178          P=0.441          P=0.188         |
|POLY 3             |        P=0.540N         P=0.611N         P=0.617N      |  P=0.128N         P=0.032N*        P=0.119N        |
|POLY 1.5           |        P=0.555N         P=0.629N         P=0.633N      |  P=0.129N         P=0.031N*        P=0.119N        |
|POLY 6             |        P=0.523N         P=0.589N         P=0.597N      |  P=0.125N         P=0.034N*        P=0.119N        |
|LOGISTIC REGRESSION|        P=0.541N         P=0.637N         P=0.627N      |  P=0.079N         P=0.021N*        (e)             |
|COCH-ARM / FISHERS |        P=0.583          P=0.661N         P=0.661N      |  P=0.133N         P=0.028N*        P=0.121N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy Chronic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        49/50 (98%)      50/50 (100%)     49/50 (98%)   |  47/50 (94%)      46/50 (92%)      46/50 (92%)     |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           98.3%         |  98.1%            98.7%            98.3%           |
|TERMINAL (d)       |        8/8 (100%)       12/12 (100%)     11/11 (100%)  |  28/28 (100%)     24/24 (100%)     22/22 (100%)    |
|FIRST INCIDENCE    |        334              380              329           |  522              280              271             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.138N         P=0.135N         P=0.152N      |  P=0.086          P=0.211          P=0.103         |
|POLY 3             |        P=0.316N         P=1.000          P=0.582N      |  P=0.693          P=0.826          P=0.864         |
|POLY 1.5           |        P=0.321N         P=1.000          P=0.566N      |  P=0.626N         P=0.751          P=0.752N        |
|POLY 6             |        P=0.367N         P=1.000          P=0.668N      |  P=0.882          P=0.993          P=0.993         |
|LOGISTIC REGRESSION|        P=0.451N         (e)              P=0.612N      |  P=0.117          P=0.179          P=0.181         |
|COCH-ARM / FISHERS |        P=0.669          P=0.500          P=0.753N      |  P=0.424N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 15

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        43/50 (86%)      44/50 (88%)      50/50 (100%)  |  48/50 (96%)      46/50 (92%)      47/50 (94%)     |
|POLY-3 ADJUSTED (b)|        93.6%            92.7%            100.0%        |  98.4%            95.7%            98.7%           |
|TERMINAL (d)       |        8/8 (100%)       11/12 (92%)      11/11 (100%)  |  28/28 (100%)     23/24 (96%)      22/22 (100%)    |
|FIRST INCIDENCE    |        334              444              329           |  493              280              294             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.416N         P=0.148N         P=0.419N      |  P=0.091          P=0.264          P=0.102         |
|POLY 3             |        P=0.053          P=0.612N         P=0.055       |  P=0.613          P=0.421N         P=0.853         |
|POLY 1.5           |        P=0.028 *        P=0.635N         P=0.025 *     |  P=0.594N         P=0.435N         P=0.769N        |
|POLY 6             |        P=0.129          P=0.580N         P=0.164       |  P=0.592          P=0.361N         P=0.939         |
|LOGISTIC REGRESSION|        P=0.025 *        P=0.539N         P=0.020 *     |  P=0.339          P=0.687          P=0.358         |
|COCH-ARM / FISHERS |        P=0.010 *        P=0.500          P=0.006 **    |  P=0.417N         P=0.339N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.8%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         1/12 (8%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              695              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.608N         P=0.329          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        P=0.625N         P=0.268          (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.643N         P=0.256          (e)           |  (e)              (e)              (e)             |
|POLY 6             |        P=0.600N         P=0.286          (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.619N         P=0.310          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.669          P=0.247          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 16

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        13/50 (26%)      3/50 (6%)     |  31/50 (62%)      17/50 (34%)      4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        9.9%             36.6%            8.6%          |  68.5%            43.0%            11.2%           |
|TERMINAL (d)       |        2/8 (25%)        8/12 (67%)       2/11 (18%)    |  23/28 (82%)      13/24 (54%)      4/22 (18%)      |
|FIRST INCIDENCE    |        713              558              607           |  552              514              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.365N         P=0.036 *        P=0.539N      |  P<0.001N**       P=0.027N*        P<0.001N**      |
|POLY 3             |        P=0.399N         P=0.009 **       P=0.600N      |  P<0.001N**       P=0.011N*        P<0.001N**      |
|POLY 1.5           |        P=0.466N         P=0.008 **       P=0.625N      |  P<0.001N**       P=0.008N**       P<0.001N**      |
|POLY 6             |        P=0.305N         P=0.012 *        P=0.563N      |  P<0.001N**       P=0.014N*        P<0.001N**      |
|LOGISTIC REGRESSION|        P=0.355N         P=0.019 *        P=0.537N      |  P<0.001N**       P=0.017N*        P<0.001N**      |
|COCH-ARM / FISHERS |        P=0.560          P=0.006 **       P=0.661N      |  P<0.001N**       P=0.004N**       P<0.001N**      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        6/50 (12%)       2/50 (4%)     |  5/50 (10%)       4/50 (8%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        9.6%             16.9%            5.8%          |  11.6%            10.6%            2.8%            |
|TERMINAL (d)       |        1/8 (13%)        3/12 (25%)       2/11 (18%)    |  4/28 (14%)       4/24 (17%)       1/22 (5%)       |
|FIRST INCIDENCE    |        458              474              729 (T)       |  632              728 (T)          728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.279N         P=0.431          P=0.374N      |  P=0.136N         P=0.598N         P=0.165N        |
|POLY 3             |        P=0.359N         P=0.302          P=0.457N      |  P=0.133N         P=0.583N         P=0.150N        |
|POLY 1.5           |        P=0.382N         P=0.280          P=0.473N      |  P=0.114N         P=0.558N         P=0.134N        |
|POLY 6             |        P=0.331N         P=0.333          P=0.438N      |  P=0.148N         P=0.601N         P=0.163N        |
|LOGISTIC REGRESSION|        P=0.337N         P=0.311          P=0.438N      |  P=0.133N         P=0.595N         P=0.157N        |
|COCH-ARM / FISHERS |        P=0.424N         P=0.243          P=0.500N      |  P=0.080N         P=0.500N         P=0.102N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 17

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        9/50 (18%)       9/50 (18%)       8/50 (16%)    |  10/50 (20%)      11/50 (22%)      14/50 (28%)     |
|POLY-3 ADJUSTED (b)|        26.1%            24.1%            21.4%         |  22.7%            28.4%            36.5%           |
|TERMINAL (d)       |        1/8 (13%)        2/12 (17%)       2/11 (18%)    |  7/28 (25%)       9/24 (38%)       5/22 (23%)      |
|FIRST INCIDENCE    |        467              511              421           |  522              514              537             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.312N         P=0.413N         P=0.376N      |  P=0.080          P=0.341          P=0.105         |
|POLY 3             |        P=0.369N         P=0.532N         P=0.421N      |  P=0.103          P=0.368          P=0.126         |
|POLY 1.5           |        P=0.396N         P=0.554N         P=0.448N      |  P=0.126          P=0.406          P=0.152         |
|POLY 6             |        P=0.337N         P=0.497N         P=0.387N      |  P=0.097          P=0.341          P=0.121         |
|LOGISTIC REGRESSION|        P=0.482N         P=0.588          P=0.557N      |  P=0.110          P=0.395          P=0.152         |
|COCH-ARM / FISHERS |        P=0.447N         P=0.602N         P=0.500N      |  P=0.204          P=0.500          P=0.241         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        20/50 (40%)      25/50 (50%)      24/50 (48%)   |  29/50 (58%)      26/50 (52%)      13/50 (26%)     |
|POLY-3 ADJUSTED (b)|        49.9%            56.4%            54.2%         |  61.9%            60.0%            33.4%           |
|TERMINAL (d)       |        2/8 (25%)        6/12 (50%)       4/11 (36%)    |  17/28 (61%)      13/24 (54%)      6/22 (27%)      |
|FIRST INCIDENCE    |        334              380              329           |  522              271              271             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.530N         P=0.509          P=0.550       |  P=0.038N*        P=0.486          P=0.033N*       |
|POLY 3             |        P=0.397          P=0.346          P=0.427       |  P=0.007N**       P=0.513N         P=0.006N**      |
|POLY 1.5           |        P=0.338          P=0.295          P=0.368       |  P=0.003N**       P=0.458N         P=0.003N**      |
|POLY 6             |        P=0.476          P=0.418          P=0.507       |  P=0.014N*        P=0.561N         P=0.011N*       |
|LOGISTIC REGRESSION|        P=0.117          P=0.104          P=0.146       |  P=0.002N**       P=0.405N         P=0.002N**      |
|COCH-ARM / FISHERS |        P=0.241          P=0.211          P=0.273       |  P<0.001N**       P=0.344N         P<0.001N**      |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 18

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  1/50 (2%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.3%             5.2%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  1/28 (4%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  728 (T)          578              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.433N         P=0.442          P=0.548N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.448N         P=0.461          P=0.536N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.421N         P=0.471          P=0.525N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.466N         P=0.457          P=0.543N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.389N         P=0.481          (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.360N         P=0.500          P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        27/50 (54%)      36/50 (72%)      33/50 (66%)   |  23/50 (46%)      20/50 (40%)      22/50 (44%)     |
|POLY-3 ADJUSTED (b)|        66.9%            78.6%            72.1%         |  51.8%            50.4%            58.5%           |
|TERMINAL (d)       |        3/8 (38%)        10/12 (83%)      5/11 (46%)    |  17/28 (61%)      13/24 (54%)      14/22 (64%)     |
|FIRST INCIDENCE    |        442              380              421           |  613              533              537             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.503N         P=0.471          P=0.541N      |  P=0.237          P=0.558          P=0.260         |
|POLY 3             |        P=0.363          P=0.142          P=0.378       |  P=0.324          P=0.536N         P=0.347         |
|POLY 1.5           |        P=0.252          P=0.101          P=0.275       |  P=0.415          P=0.480N         P=0.443         |
|POLY 6             |        P=0.530          P=0.201          P=0.529       |  P=0.273          P=0.567N         P=0.292         |
|LOGISTIC REGRESSION|        P=0.140          P=0.066          P=0.173       |  P=0.259          P=0.580N         P=0.278         |
|COCH-ARM / FISHERS |        P=0.126          P=0.048 *        P=0.154       |  P=0.460N         P=0.343N         P=0.500N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 19

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        47/50 (94%)      48/50 (96%)      50/50 (100%)  |  26/50 (52%)      21/50 (42%)      16/50 (32%)     |
|POLY-3 ADJUSTED (b)|        98.4%            96.2%            100.0%        |  56.8%            49.9%            39.8%           |
|TERMINAL (d)       |        8/8 (100%)       12/12 (100%)     11/11 (100%)  |  15/28 (54%)      10/24 (42%)      8/22 (36%)      |
|FIRST INCIDENCE    |        334              380              329           |  522              382              373             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.227N         P=0.143N         P=0.239N      |  P=0.209N         P=0.484N         P=0.221N        |
|POLY 3             |        P=0.395          P=0.479N         P=0.646       |  P=0.068N         P=0.327N         P=0.081N        |
|POLY 1.5           |        P=0.271          P=0.590N         P=0.371       |  P=0.051N         P=0.298N         P=0.062N        |
|POLY 6             |        P=0.540          P=0.377N         P=0.986       |  P=0.083N         P=0.333N         P=0.098N        |
|LOGISTIC REGRESSION|        P=0.141          P=0.666          P=0.247       |  P=0.049N*        P=0.308N         P=0.057N        |
|COCH-ARM / FISHERS |        P=0.082          P=0.500          P=0.121       |  P=0.027N*        P=0.212N         P=0.034N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       8/50 (16%)       3/50 (6%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        25.3%            22.4%            8.6%          |  0.0%             0.0%             2.8%            |
|TERMINAL (d)       |        4/8 (50%)        3/12 (25%)       1/11 (9%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        603              617              627           |  ---              ---              665             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.029N*        P=0.340N         P=0.036N*     |  P=0.251          (e)              P=0.470         |
|POLY 3             |        P=0.050N         P=0.506N         P=0.062N      |  P=0.274          (e)              P=0.465         |
|POLY 1.5           |        P=0.063N         P=0.543N         P=0.075N      |  P=0.273          (e)              P=0.476         |
|POLY 6             |        P=0.038N*        P=0.456N         P=0.048N*     |  P=0.275          (e)              P=0.460         |
|LOGISTIC REGRESSION|        P=0.036N*        P=0.419N         P=0.049N*     |  P=0.258          (e)              P=0.489         |
|COCH-ARM / FISHERS |        P=0.088N         P=0.607N         P=0.100N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 20

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        1/50 (2%)     |  1/50 (2%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.2%             8.5%             2.9%          |  2.3%             5.3%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        521              589              582           |  618              712              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.551N         P=0.411          P=0.743N      |  P=0.426N         P=0.443          P=0.542N        |
|POLY 3             |        P=0.557N         P=0.352          P=0.735N      |  P=0.452N         P=0.454          P=0.538N        |
|POLY 1.5           |        P=0.577N         P=0.334          P=0.745N      |  P=0.423N         P=0.468          P=0.526N        |
|POLY 6             |        P=0.530N         P=0.379          P=0.721N      |  P=0.473N         P=0.445          P=0.546N        |
|LOGISTIC REGRESSION|        P=0.606N         P=0.324          P=0.730       |  P=0.397N         P=0.473          P=0.468N        |
|COCH-ARM / FISHERS |        P=0.610          P=0.309          P=0.753N      |  P=0.360N         P=0.500          P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)     |  2/50 (4%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        6.5%             2.9%             0.0%          |  4.7%             2.7%             5.6%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        543              589              ---           |  697              708              672             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.118N         P=0.427N         P=0.205N      |  P=0.520          P=0.553N         P=0.602         |
|POLY 3             |        P=0.130N         P=0.455N         P=0.213N      |  P=0.564          P=0.544N         P=0.628         |
|POLY 1.5           |        P=0.134N         P=0.472N         P=0.222N      |  P=0.579          P=0.532N         P=0.648         |
|POLY 6             |        P=0.125N         P=0.432N         P=0.201N      |  P=0.555          P=0.553N         P=0.614         |
|LOGISTIC REGRESSION|        P=0.140N         P=0.494N         P=0.223N      |  P=0.538          P=0.547N         P=0.626         |
|COCH-ARM / FISHERS |        P=0.142N         P=0.500N         P=0.247N      |  P=0.610          P=0.500N         P=0.691N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 21

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.5%             2.9%             0.0%          |  2.3%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        650              686              ---           |  708              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.094N         P=0.372N         P=0.196N      |  P=0.304N         P=0.527N         P=0.549N        |
|POLY 3             |        P=0.129N         P=0.456N         P=0.211N      |  P=0.303N         P=0.525N         P=0.536N        |
|POLY 1.5           |        P=0.134N         P=0.472N         P=0.221N      |  P=0.292N         P=0.518N         P=0.525N        |
|POLY 6             |        P=0.124N         P=0.434N         P=0.200N      |  P=0.310N         P=0.530N         P=0.544N        |
|LOGISTIC REGRESSION|        P=0.109N         P=0.428N         P=0.196N      |  P=0.299N         P=0.528N         P=0.542N        |
|COCH-ARM / FISHERS |        P=0.142N         P=0.500N         P=0.247N      |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        8/50 (16%)       2/50 (4%)     |  7/50 (14%)       16/50 (32%)      9/50 (18%)      |
|POLY-3 ADJUSTED (b)|        6.5%             21.9%            5.8%          |  16.4%            40.6%            24.8%           |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        0/11 (0%)     |  7/28 (25%)       11/24 (46%)      7/22 (32%)      |
|FIRST INCIDENCE    |        591              561              674           |  728 (T)          578              537             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.439N         P=0.131          P=0.577N      |  P=0.152          P=0.008 **       P=0.203         |
|POLY 3             |        P=0.471N         P=0.073          P=0.652N      |  P=0.172          P=0.012 *        P=0.259         |
|POLY 1.5           |        P=0.511N         P=0.061          P=0.668N      |  P=0.220          P=0.014 *        P=0.296         |
|POLY 6             |        P=0.416N         P=0.097          P=0.628N      |  P=0.148          P=0.011 *        P=0.238         |
|LOGISTIC REGRESSION|        P=0.496N         P=0.072          P=0.636N      |  P=0.175          P=0.009 **       P=0.214         |
|COCH-ARM / FISHERS |        P=0.573          P=0.046 *        P=0.691N      |  P=0.357          P=0.028 *        P=0.393         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 22

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  3/50 (6%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        6.5%             0.0%             0.0%          |  7.0%             2.7%             2.8%            |
|TERMINAL (d)       |        1/8 (13%)        0/12 (0%)        0/11 (0%)     |  2/28 (7%)        1/24 (4%)        1/22 (5%)       |
|FIRST INCIDENCE    |        631              ---              ---           |  655              728 (T)          728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.070N         P=0.187N         P=0.184N      |  P=0.268N         P=0.361N         P=0.389N        |
|POLY 3             |        P=0.093N         P=0.209N         P=0.211N      |  P=0.253N         P=0.353N         P=0.375N        |
|POLY 1.5           |        P=0.094N         P=0.219N         P=0.221N      |  P=0.237N         P=0.339N         P=0.353N        |
|POLY 6             |        P=0.094N         P=0.196N         P=0.199N      |  P=0.266N         P=0.364N         P=0.391N        |
|LOGISTIC REGRESSION|        P=0.074N         P=0.191N         P=0.194N      |  P=0.264N         P=0.356N         P=0.383N        |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |  P=0.202N         P=0.309N         P=0.309N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.5%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        618              ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.075N         P=0.213N         P=0.190N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.093N         P=0.212N         P=0.214N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.094N         P=0.220N         P=0.222N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.093N         P=0.202N         P=0.204N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.091N         P=0.227N         P=0.227N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 23

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        1/50 (2%)     |  2/50 (4%)        1/50 (2%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        6.5%             11.4%            2.9%          |  4.6%             2.6%             8.4%            |
|TERMINAL (d)       |        0/8 (0%)         2/12 (17%)       0/11 (0%)     |  0/28 (0%)        0/24 (0%)        3/22 (14%)      |
|FIRST INCIDENCE    |        618              611              626           |  632              585              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.288N         P=0.486          P=0.406N      |  P=0.311          P=0.560N         P=0.396         |
|POLY 3             |        P=0.346N         P=0.396          P=0.460N      |  P=0.350          P=0.544N         P=0.412         |
|POLY 1.5           |        P=0.368N         P=0.374          P=0.475N      |  P=0.366          P=0.531N         P=0.440         |
|POLY 6             |        P=0.319N         P=0.426          P=0.441N      |  P=0.338          P=0.552N         P=0.391         |
|LOGISTIC REGRESSION|        P=0.347N         P=0.418          P=0.481N      |  P=0.352          P=0.458N         P=0.418         |
|COCH-ARM / FISHERS |        P=0.406N         P=0.339          P=0.500N      |  P=0.399          P=0.500N         P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/50 (14%)       13/50 (26%)      12/50 (24%)   |  22/50 (44%)      24/50 (48%)      28/50 (56%)     |
|POLY-3 ADJUSTED (b)|        21.9%            33.7%            32.3%         |  50.5%            57.9%            69.7%           |
|TERMINAL (d)       |        2/8 (25%)        4/12 (33%)       4/11 (36%)    |  19/28 (68%)      15/24 (63%)      18/22 (82%)     |
|FIRST INCIDENCE    |        543              495              565           |  619              271              374             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.310          P=0.280          P=0.334       |  P=0.013 *        P=0.189          P=0.012 *       |
|POLY 3             |        P=0.230          P=0.197          P=0.238       |  P=0.040 *        P=0.312          P=0.048 *       |
|POLY 1.5           |        P=0.189          P=0.155          P=0.201       |  P=0.058          P=0.334          P=0.069         |
|POLY 6             |        P=0.296          P=0.273          P=0.302       |  P=0.034 *        P=0.321          P=0.040 *       |
|LOGISTIC REGRESSION|        P=0.189          P=0.149          P=0.232       |  P=0.027 *        P=0.226          P=0.025 *       |
|COCH-ARM / FISHERS |        P=0.136          P=0.105          P=0.154       |  P=0.136          P=0.421          P=0.159         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 24

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Interstitium                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.4%             11.3%            5.7%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        593              575              656           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.489N         P=0.478          P=0.590N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.530N         P=0.394          P=0.655N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.551N         P=0.373          P=0.670N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.502N         P=0.422          P=0.636N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.539N         P=0.393          P=0.679N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.588          P=0.339          P=0.691N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        29/50 (58%)      26/50 (52%)      33/50 (66%)   |  38/50 (76%)      35/50 (70%)      34/50 (68%)     |
|POLY-3 ADJUSTED (b)|        70.1%            60.3%            74.5%         |  79.3%            73.8%            78.1%           |
|TERMINAL (d)       |        5/8 (63%)        7/12 (58%)       8/11 (73%)    |  23/28 (82%)      16/24 (67%)      15/22 (68%)     |
|FIRST INCIDENCE    |        334              380              389           |  342              271              294             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.414N         P=0.113N         P=0.413N      |  P=0.306          P=0.414          P=0.326         |
|POLY 3             |        P=0.342          P=0.219N         P=0.406       |  P=0.482N         P=0.342N         P=0.548N        |
|POLY 1.5           |        P=0.309          P=0.249N         P=0.360       |  P=0.407N         P=0.353N         P=0.461N        |
|POLY 6             |        P=0.375          P=0.204N         P=0.455       |  P=0.497N         P=0.314N         P=0.569N        |
|LOGISTIC REGRESSION|        P=0.249          P=0.342N         P=0.313       |  P=0.283N         P=0.294N         P=0.442N        |
|COCH-ARM / FISHERS |        P=0.239          P=0.344N         P=0.268       |  P=0.219N         P=0.326N         P=0.252N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 25

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/49 (2%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.4%             5.7%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        723              670              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.278N         P=0.656          P=0.460N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.313N         P=0.558          P=0.470N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.329N         P=0.539          P=0.480N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.293N         P=0.586          P=0.457N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.284N         P=0.615          P=0.444N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.355N         P=0.508          P=0.495N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/48 (4%)        6/49 (12%)       4/50 (8%)     |  0/49 (0%)        3/50 (6%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        7.0%             17.4%            11.5%         |  0.0%             8.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        2/12 (17%)       2/11 (18%)    |  0/28 (0%)        2/24 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        656              575              586           |  ---              719              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.432          P=0.293          P=0.478       |  P=0.570          P=0.097          (e)             |
|POLY 3             |        P=0.415          P=0.191          P=0.427       |  P=0.557          P=0.100          (e)             |
|POLY 1.5           |        P=0.372          P=0.170          P=0.398       |  P=0.586          P=0.106          (e)             |
|POLY 6             |        P=0.474          P=0.225          P=0.467       |  P=0.537          P=0.096          (e)             |
|LOGISTIC REGRESSION|        P=0.442          P=0.233          P=0.483       |  P=0.575          P=0.094          (e)             |
|COCH-ARM / FISHERS |        P=0.311          P=0.141          P=0.359       |  P=0.634N         P=0.125          (e)             |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 26

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        36/48 (75%)      44/49 (90%)      43/50 (86%)   |  44/49 (90%)      40/50 (80%)      40/50 (80%)     |
|POLY-3 ADJUSTED (b)|        85.1%            94.7%            92.4%         |  92.8%            87.7%            91.3%           |
|TERMINAL (d)       |        7/8 (88%)        12/12 (100%)     9/11 (82%)    |  26/28 (93%)      20/24 (83%)      20/22 (91%)     |
|FIRST INCIDENCE    |        334              444              329           |  493              280              314             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.433N         P=0.465N         P=0.460N      |  P=0.221          P=0.406          P=0.238         |
|POLY 3             |        P=0.133          P=0.084          P=0.190       |  P=0.455N         P=0.304N         P=0.552N        |
|POLY 1.5           |        P=0.112          P=0.066          P=0.160       |  P=0.311N         P=0.247N         P=0.377N        |
|POLY 6             |        P=0.222          P=0.148          P=0.294       |  P=0.561N         P=0.338N         P=0.673N        |
|LOGISTIC REGRESSION|        P=0.195          P=0.107          P=0.232       |  P=0.471N         P=0.366N         P=0.606N        |
|COCH-ARM / FISHERS |        P=0.094          P=0.049 *        P=0.131       |  P=0.122N         P=0.140N         P=0.140N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/8 (88%)        3/7 (43%)        5/6 (83%)     |  3/4 (75%)        4/5 (80%)        1/2 (50%)       |
|POLY-3 ADJUSTED (b)|        88.7%            46.8%            88.1%         |  75.0%            91.1%            50.0%           |
|TERMINAL (d)       |        2/2 (100%)       1/3 (33%)        1/1 (100%)    |  0/1 (0%)         3/3 (100%)       0/1 (0%)        |
|FIRST INCIDENCE    |        392              499              389           |  613              280              545             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.309N         P=0.071N         P=0.413N      |  P=0.294N         P=0.651N         P=0.405N        |
|POLY 3             |        P=0.540N         P=0.109N         P=0.800N      |  P=0.514N         P=0.617          P=0.602N        |
|POLY 1.5           |        P=0.512N         P=0.099N         P=0.750N      |  P=0.502N         P=0.664          P=0.602N        |
|POLY 6             |        P=0.585N         P=0.124N         P=0.822       |  P=0.528N         P=0.552          P=0.602N        |
|LOGISTIC REGRESSION|        P=0.500N         P=0.170N         P=0.716N      |  P=0.459N         P=0.742          (e)             |
|COCH-ARM / FISHERS |        P=0.483N         P=0.100N         P=0.692N      |  P=0.483N         P=0.722          P=0.600N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 27

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        9/50 (18%)       7/50 (14%)       10/50 (20%)   |  1/50 (2%)        4/50 (8%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        27.6%            18.6%            26.4%         |  2.3%             10.3%            8.0%            |
|TERMINAL (d)       |        4/8 (50%)        0/12 (0%)        2/11 (18%)    |  1/28 (4%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        458              511              389           |  728 (T)          225              373             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.476N         P=0.223N         P=0.506N      |  P=0.203          P=0.153          P=0.256         |
|POLY 3             |        P=0.546N         P=0.267N         P=0.560N      |  P=0.198          P=0.151          P=0.260         |
|POLY 1.5           |        P=0.526          P=0.315N         P=0.594       |  P=0.213          P=0.159          P=0.273         |
|POLY 6             |        P=0.492N         P=0.201N         P=0.478N      |  P=0.191          P=0.148          P=0.255         |
|LOGISTIC REGRESSION|        P=0.449          P=0.357N         P=0.539       |  P=0.394          P=0.231          P=0.510         |
|COCH-ARM / FISHERS |        P=0.447          P=0.393N         P=0.500       |  P=0.252          P=0.181          P=0.309         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Nasolacrimal Duct                                                                                                          |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        4/50 (8%)     |  4/50 (8%)        3/50 (6%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        6.5%             11.1%            11.4%         |  9.3%             7.7%             8.4%            |
|TERMINAL (d)       |        0/8 (0%)         1/12 (8%)        0/11 (0%)     |  3/28 (11%)       1/24 (4%)        1/22 (5%)       |
|FIRST INCIDENCE    |        561              495              632           |  655              280              665             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.396          P=0.465          P=0.477       |  P=0.525N         P=0.570N         P=0.614N        |
|POLY 3             |        P=0.341          P=0.409          P=0.397       |  P=0.518N         P=0.550N         P=0.597N        |
|POLY 1.5           |        P=0.314          P=0.381          P=0.373       |  P=0.489N         P=0.536N         P=0.568N        |
|POLY 6             |        P=0.382          P=0.451          P=0.436       |  P=0.536N         P=0.558N         P=0.615N        |
|LOGISTIC REGRESSION|        P=0.308          P=0.356          P=0.402       |  P=0.423N         P=0.428N         P=0.613N        |
|COCH-ARM / FISHERS |        P=0.274          P=0.339          P=0.339       |  P=0.421N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 28

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        9/50 (18%)       7/50 (14%)       9/50 (18%)    |  1/50 (2%)        4/50 (8%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        27.3%            18.6%            23.9%         |  2.3%             10.3%            8.0%            |
|TERMINAL (d)       |        3/8 (38%)        0/12 (0%)        2/11 (18%)    |  1/28 (4%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        458              511              389           |  728 (T)          225              373             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.388N         P=0.236N         P=0.427N      |  P=0.203          P=0.153          P=0.256         |
|POLY 3             |        P=0.453N         P=0.276N         P=0.480N      |  P=0.198          P=0.151          P=0.260         |
|POLY 1.5           |        P=0.489N         P=0.320N         P=0.526N      |  P=0.213          P=0.159          P=0.273         |
|POLY 6             |        P=0.411N         P=0.218N         P=0.419N      |  P=0.191          P=0.148          P=0.255         |
|LOGISTIC REGRESSION|        P=0.543          P=0.376N         P=0.583N      |  P=0.394          P=0.231          P=0.510         |
|COCH-ARM / FISHERS |        P=0.553          P=0.393N         P=0.602N      |  P=0.252          P=0.181          P=0.309         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        3/50 (6%)     |  0/50 (0%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        9.5%             5.6%             8.5%          |  0.0%             2.6%             5.4%            |
|TERMINAL (d)       |        1/8 (13%)        0/12 (0%)        1/11 (9%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        458              511              389           |  ---              225              373             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.512N         P=0.418N         P=0.574N      |  P=0.134          P=0.500          P=0.219         |
|POLY 3             |        P=0.548N         P=0.442N         P=0.608N      |  P=0.126          P=0.480          P=0.208         |
|POLY 1.5           |        P=0.562N         P=0.464N         P=0.628N      |  P=0.131          P=0.486          P=0.216         |
|POLY 6             |        P=0.532N         P=0.412N         P=0.581N      |  P=0.123          P=0.477          P=0.203         |
|LOGISTIC REGRESSION|        P=0.531          P=0.552N         P=0.635       |  P=0.374          (e)              P=0.630         |
|COCH-ARM / FISHERS |        P=0.588          P=0.500N         P=0.661N      |  P=0.142          P=0.500          P=0.247         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 29

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Vein, Turbinate, Septum                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.5%             0.0%             5.8%          |  2.3%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        650              ---              690           |  697              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.559N         P=0.167N         P=0.614N      |  P=0.309N         P=0.539N         P=0.554N        |
|POLY 3             |        P=0.615N         P=0.209N         P=0.652N      |  P=0.303N         P=0.525N         P=0.536N        |
|POLY 1.5           |        P=0.616N         P=0.219N         P=0.668N      |  P=0.292N         P=0.518N         P=0.525N        |
|POLY 6             |        P=0.613N         P=0.197N         P=0.630N      |  P=0.310N         P=0.530N         P=0.544N        |
|LOGISTIC REGRESSION|        P=0.561N         P=0.193N         P=0.619N      |  P=0.294N         P=0.523N         P=0.536N        |
|COCH-ARM / FISHERS |        P=0.622          P=0.247N         P=0.691N      |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  7/50 (14%)       8/50 (16%)       8/50 (16%)      |
|POLY-3 ADJUSTED (b)|                                                        |  16.2%            21.2%            21.3%           |
|TERMINAL (d)       |                                                        |  3/28 (11%)       7/24 (29%)       3/22 (14%)      |
|FIRST INCIDENCE    |                                                        |  636              722              387             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.269          P=0.374          P=0.327         |
|POLY 3             |                                                        |  P=0.324          P=0.384          P=0.382         |
|POLY 1.5           |                                                        |  P=0.358          P=0.420          P=0.415         |
|POLY 6             |                                                        |  P=0.307          P=0.355          P=0.368         |
|LOGISTIC REGRESSION|                                                        |  P=0.308          P=0.373          P=0.423         |
|COCH-ARM / FISHERS |                                                        |  P=0.445          P=0.500          P=0.500         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 30

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      22/50 (44%)      25/50 (50%)   |  19/50 (38%)      13/50 (26%)      11/50 (22%)     |
|POLY-3 ADJUSTED (b)|        33.2%            53.9%            61.2%         |  42.1%            32.6%            28.0%           |
|TERMINAL (d)       |        3/8 (38%)        6/12 (50%)       8/11 (73%)    |  13/28 (46%)      7/24 (29%)       5/22 (23%)      |
|FIRST INCIDENCE    |        392              444              421           |  552              533              308             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.047 *        P=0.152          P=0.054       |  P=0.195N         P=0.315N         P=0.225N        |
|POLY 3             |        P=0.010 *        P=0.050          P=0.009 **    |  P=0.099N         P=0.245N         P=0.128N        |
|POLY 1.5           |        P=0.006 **       P=0.031 *        P=0.005 **    |  P=0.079N         P=0.212N         P=0.103N        |
|POLY 6             |        P=0.021 *        P=0.099          P=0.019 *     |  P=0.115N         P=0.267N         P=0.147N        |
|LOGISTIC REGRESSION|        P=0.005 **       P=0.030 *        P=0.007 **    |  P=0.070N         P=0.210N         P=0.071N        |
|COCH-ARM / FISHERS |        P=0.003 **       P=0.016 *        P=0.003 **    |  P=0.049N*        P=0.142N         P=0.063N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        14/48 (29%)      15/46 (33%)      8/45 (18%)    |  0/42 (0%)        1/46 (2%)        3/45 (7%)       |
|POLY-3 ADJUSTED (b)|        41.7%            44.7%            24.6%         |  0.0%             2.9%             9.2%            |
|TERMINAL (d)       |        1/8 (13%)        5/11 (46%)       2/9 (22%)     |  0/22 (0%)        0/21 (0%)        0/20 (0%)       |
|FIRST INCIDENCE    |        563              575              626           |  ---              562              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.046N*        P=0.340N         P=0.058N      |  P=0.045 *        P=0.472          P=0.091         |
|POLY 3             |        P=0.084N         P=0.496          P=0.102N      |  P=0.054          P=0.497          P=0.105         |
|POLY 1.5           |        P=0.097N         P=0.492          P=0.113N      |  P=0.057          P=0.502          P=0.111         |
|POLY 6             |        P=0.080N         P=0.477          P=0.099N      |  P=0.054          P=0.496          P=0.105         |
|LOGISTIC REGRESSION|        P=0.054N         P=0.573N         P=0.082N      |  P=0.067          P=0.590          P=0.128         |
|COCH-ARM / FISHERS |        P=0.135N         P=0.445          P=0.147N      |  P=0.065          P=0.523          P=0.134         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 31

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        16/50 (32%)      7/50 (14%)       3/49 (6%)     |  23/50 (46%)      27/49 (55%)      17/50 (34%)     |
|POLY-3 ADJUSTED (b)|        43.7%            19.6%            8.6%          |  51.2%            64.4%            44.6%           |
|TERMINAL (d)       |        3/8 (38%)        2/12 (17%)       1/11 (9%)     |  16/28 (57%)      18/24 (75%)      14/22 (64%)     |
|FIRST INCIDENCE    |        458              617              565           |  342              225              308             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001N**       P=0.011N*        P<0.001N**    |  P=0.462N         P=0.108          P=0.454N        |
|POLY 3             |        P<0.001N**       P=0.020N*        P<0.001N**    |  P=0.370N         P=0.143          P=0.347N        |
|POLY 1.5           |        P<0.001N**       P=0.020N*        P<0.001N**    |  P=0.276N         P=0.166          P=0.273N        |
|POLY 6             |        P<0.001N**       P=0.020N*        P<0.001N**    |  P=0.464N         P=0.134          P=0.422N        |
|LOGISTIC REGRESSION|        P<0.001N**       P=0.021N*        P<0.001N**    |  P=0.258N         P=0.158          P=0.308N        |
|COCH-ARM / FISHERS |        P<0.001N**       P=0.028N*        P<0.001N**    |  P=0.134N         P=0.241          P=0.154N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        13/50 (26%)      10/50 (20%)      12/49 (24%)   |  20/50 (40%)      19/49 (39%)      19/50 (38%)     |
|POLY-3 ADJUSTED (b)|        37.5%            27.0%            33.1%         |  44.5%            45.1%            48.2%           |
|TERMINAL (d)       |        3/8 (38%)        4/12 (33%)       5/11 (46%)    |  12/28 (43%)      11/24 (46%)      12/22 (55%)     |
|FIRST INCIDENCE    |        470              499              474           |  493              225              314             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.232N         P=0.139N         P=0.256N      |  P=0.303          P=0.441          P=0.332         |
|POLY 3             |        P=0.406N         P=0.236N         P=0.445N      |  P=0.414          P=0.563          P=0.451         |
|POLY 1.5           |        P=0.425N         P=0.260N         P=0.467N      |  P=0.482          P=0.583          P=0.521         |
|POLY 6             |        P=0.389N         P=0.211N         P=0.427N      |  P=0.361          P=0.549          P=0.395         |
|LOGISTIC REGRESSION|        P=0.361N         P=0.250N         P=0.396N      |  P=0.521N         P=0.532N         P=0.522         |
|COCH-ARM / FISHERS |        P=0.475N         P=0.318N         P=0.523N      |  P=0.459N         P=0.532N         P=0.500N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 32

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        1/49 (2%)     |  1/50 (2%)        2/49 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        3.2%             0.0%             2.9%          |  2.3%             5.2%             5.4%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        1/24 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        467              ---              474           |  669              225              466             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.646N         P=0.478N         P=0.735N      |  P=0.337          P=0.469          P=0.436         |
|POLY 3             |        P=0.671N         P=0.478N         P=0.735N      |  P=0.341          P=0.460          P=0.448         |
|POLY 1.5           |        P=0.671N         P=0.486N         P=0.746N      |  P=0.355          P=0.470          P=0.463         |
|POLY 6             |        P=0.673N         P=0.467N         P=0.720N      |  P=0.333          P=0.454          P=0.440         |
|LOGISTIC REGRESSION|        P=0.515          P=0.621N         P=0.653       |  P=0.579          P=0.668          P=0.666         |
|COCH-ARM / FISHERS |        P=0.665          P=0.500N         P=0.747       |  P=0.391          P=0.492          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        1/50 (2%)        3/50 (6%)     |                                                    |
|POLY-3 ADJUSTED (b)|        9.6%             2.9%             8.8%          |                                                    |
|TERMINAL (d)       |        1/8 (13%)        0/12 (0%)        3/11 (27%)    |                                                    |
|FIRST INCIDENCE    |        467              713              729 (T)       |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.497N         P=0.225N         P=0.538N      |                                                    |
|POLY 3             |        P=0.574N         P=0.268N         P=0.623N      |                                                    |
|POLY 1.5           |        P=0.580N         P=0.281N         P=0.637N      |                                                    |
|POLY 6             |        P=0.568N         P=0.251N         P=0.607N      |                                                    |
|LOGISTIC REGRESSION|        P=0.525N         P=0.283N         P=0.592N      |                                                    |
|COCH-ARM / FISHERS |        P=0.594          P=0.309N         P=0.661N      |                                                    |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 33

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        47/50 (94%)      46/50 (92%)      46/50 (92%)   |                                                    |
|POLY-3 ADJUSTED (b)|        96.9%            94.9%            96.0%         |                                                    |
|TERMINAL (d)       |        7/8 (88%)        10/12 (83%)      11/11 (100%)  |                                                    |
|FIRST INCIDENCE    |        334              444              329           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.121N         P=0.105N         P=0.130N      |                                                    |
|POLY 3             |        P=0.515N         P=0.513N         P=0.645N      |                                                    |
|POLY 1.5           |        P=0.408N         P=0.469N         P=0.510N      |                                                    |
|POLY 6             |        P=0.593          P=0.532N         P=0.749       |                                                    |
|LOGISTIC REGRESSION|        P=0.291N         P=0.349N         P=0.362N      |                                                    |
|COCH-ARM / FISHERS |        P=0.424N         P=0.500N         P=0.500N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Cyst Multilocular                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        9/50 (18%)       8/50 (16%)       4/50 (8%)     |                                                    |
|POLY-3 ADJUSTED (b)|        28.0%            21.8%            11.3%         |                                                    |
|TERMINAL (d)       |        2/8 (25%)        1/12 (8%)        2/11 (18%)    |                                                    |
|FIRST INCIDENCE    |        556              558              552           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.043N*        P=0.266N         P=0.055N      |                                                    |
|POLY 3             |        P=0.057N         P=0.374N         P=0.071N      |                                                    |
|POLY 1.5           |        P=0.070N         P=0.421N         P=0.086N      |                                                    |
|POLY 6             |        P=0.046N*        P=0.315N         P=0.056N      |                                                    |
|LOGISTIC REGRESSION|        P=0.058N         P=0.368N         P=0.068N      |                                                    |
|COCH-ARM / FISHERS |        P=0.097N         P=0.500N         P=0.117N      |                                                    |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 34

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        46/50 (92%)      47/50 (94%)      46/50 (92%)   |                                                    |
|POLY-3 ADJUSTED (b)|        92.7%            97.0%            94.3%         |                                                    |
|TERMINAL (d)       |        6/8 (75%)        11/12 (92%)      10/11 (91%)   |                                                    |
|FIRST INCIDENCE    |        110              444              329           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.152N         P=0.161N         P=0.172N      |                                                    |
|POLY 3             |        P=0.435          P=0.294          P=0.531       |                                                    |
|POLY 1.5           |        P=0.498          P=0.355          P=0.580       |                                                    |
|POLY 6             |        P=0.365          P=0.271          P=0.473       |                                                    |
|LOGISTIC REGRESSION|        P=0.552          P=0.468          P=0.553       |                                                    |
|COCH-ARM / FISHERS |        P=0.576          P=0.500          P=0.643N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.3%             0.0%             0.0%          |  0.0%             5.2%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        603              ---              ---           |  ---              578              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.247N         P=0.473N         P=0.467N      |  P=0.619          P=0.210          (e)             |
|POLY 3             |        P=0.276N         P=0.476N         P=0.478N      |  P=0.605          P=0.214          (e)             |
|POLY 1.5           |        P=0.273N         P=0.485N         P=0.486N      |  P=0.625          P=0.220          (e)             |
|POLY 6             |        P=0.280N         P=0.465N         P=0.467N      |  P=0.591          P=0.213          (e)             |
|LOGISTIC REGRESSION|        P=0.275N         P=0.507N         P=0.505N      |  P=0.646N         P=0.267          (e)             |
|COCH-ARM / FISHERS |        P=0.269N         P=0.500N         P=0.500N      |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 35

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.6%             0.0%          |  0.0%             2.6%             5.5%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        ---              529              ---           |  ---              677              466             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.639N         P=0.277          (e)           |  P=0.112          P=0.482          P=0.197         |
|POLY 3             |        P=0.625N         P=0.274          (e)           |  P=0.123          P=0.476          P=0.203         |
|POLY 1.5           |        P=0.643N         P=0.259          (e)           |  P=0.129          P=0.483          P=0.213         |
|POLY 6             |        P=0.600N         P=0.297          (e)           |  P=0.120          P=0.473          P=0.197         |
|LOGISTIC REGRESSION|        P=0.634          P=0.198          (e)           |  P=0.149          P=0.488          P=0.280         |
|COCH-ARM / FISHERS |        P=0.669          P=0.247          (e)           |  P=0.142          P=0.500          P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis, Skin, Site of Application                                                                                       |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        36/50 (72%)      48/50 (96%)   |  3/50 (6%)        45/50 (90%)      47/50 (94%)     |
|POLY-3 ADJUSTED (b)|        0.0%             83.7%            98.3%         |  6.9%             92.9%            94.0%           |
|TERMINAL (d)       |        0/8 (0%)         12/12 (100%)     11/11 (100%)  |  1/28 (4%)        21/24 (88%)      19/22 (86%)     |
|FIRST INCIDENCE    |        ---              495              329           |  585              225              271             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 36

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis, Skin, Site of Application                                                                                       |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        46/50 (92%)      50/50 (100%)  |  3/50 (6%)        46/50 (92%)      50/50 (100%)    |
|POLY-3 ADJUSTED (b)|        0.0%             94.4%            100.0%        |  6.9%             95.6%            100.0%          |
|TERMINAL (d)       |        0/8 (0%)         12/12 (100%)     11/11 (100%)  |  1/28 (4%)        23/24 (96%)      22/22 (100%)    |
|FIRST INCIDENCE    |        ---              380              329           |  585              225              271             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis, Skin, Site of Application                                                                                       |
|     Parakeratosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        9/50 (18%)       28/50 (56%)   |  1/50 (2%)        11/50 (22%)      23/50 (46%)     |
|POLY-3 ADJUSTED (b)|        0.0%             25.0%            64.6%         |  2.3%             28.2%            55.2%           |
|TERMINAL (d)       |        0/8 (0%)         3/12 (25%)       5/11 (46%)    |  0/28 (0%)        6/24 (25%)       8/22 (36%)      |
|FIRST INCIDENCE    |        ---              558              329           |  585              578              271             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P=0.014 *        P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P=0.003 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P=0.003 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P=0.005 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.005 **       P<0.001 **    |  P<0.001 **       P=0.002 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.002 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 37

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis, Skin, Site of Application                                                                                       |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)     |  2/50 (4%)        0/50 (0%)        9/50 (18%)      |
|POLY-3 ADJUSTED (b)|        0.0%             2.9%             2.9%          |  4.6%             0.0%             23.4%           |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        1/11 (9%)     |  1/28 (4%)        0/24 (0%)        3/22 (14%)      |
|FIRST INCIDENCE    |        ---              677              729 (T)       |  585              ---              308             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.399          P=0.567          P=0.564       |  P=0.004 **       P=0.285N         P=0.014 *       |
|POLY 3             |        P=0.376          P=0.528          P=0.525       |  P=0.003 **       P=0.269N         P=0.014 *       |
|POLY 1.5           |        P=0.359          P=0.517          P=0.515       |  P=0.004 **       P=0.259N         P=0.016 *       |
|POLY 6             |        P=0.401          P=0.544          P=0.539       |  P=0.003 **       P=0.275N         P=0.012 *       |
|LOGISTIC REGRESSION|        P=0.378          P=0.539          P=0.564       |  P=0.007 **       P=0.230N         P=0.037 *       |
|COCH-ARM / FISHERS |        P=0.331          P=0.500          P=0.500       |  P=0.006 **       P=0.247N         P=0.026 *       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Sebaceous Gland, Skin, Site of Application                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        45/50 (90%)      50/50 (100%)  |  2/50 (4%)        46/50 (92%)      49/50 (98%)     |
|POLY-3 ADJUSTED (b)|        0.0%             94.2%            100.0%        |  4.6%             95.9%            98.0%           |
|TERMINAL (d)       |        0/8 (0%)         12/12 (100%)     11/11 (100%)  |  1/28 (4%)        23/24 (96%)      21/22 (96%)     |
|FIRST INCIDENCE    |        ---              380              329           |  585              225              271             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 38

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)     |  3/50 (6%)        0/50 (0%)        6/50 (12%)      |
|POLY-3 ADJUSTED (b)|        0.0%             2.9%             5.8%          |  6.9%             0.0%             16.3%           |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        1/11 (9%)     |  1/28 (4%)        0/24 (0%)        2/22 (9%)       |
|FIRST INCIDENCE    |        ---              677              632           |  585              ---              545             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.191          P=0.567          P=0.304       |  P=0.097          P=0.158N         P=0.155         |
|POLY 3             |        P=0.170          P=0.528          P=0.267       |  P=0.118          P=0.146N         P=0.165         |
|POLY 1.5           |        P=0.159          P=0.517          P=0.255       |  P=0.126          P=0.137N         P=0.186         |
|POLY 6             |        P=0.187          P=0.544          P=0.286       |  P=0.113          P=0.153N         P=0.154         |
|LOGISTIC REGRESSION|        P=0.165          P=0.539          P=0.279       |  P=0.123          P=0.113N         P=0.207         |
|COCH-ARM / FISHERS |        P=0.142          P=0.500          P=0.247       |  P=0.146          P=0.121N         P=0.243         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       5/50 (10%)       1/50 (2%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        18.6%            14.1%            2.9%          |  2.3%             0.0%             0.0%            |
|TERMINAL (d)       |        2/8 (25%)        2/12 (17%)       0/11 (0%)     |  1/28 (4%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        495              611              632           |  728 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.024N*        P=0.321N         P=0.034N*     |  P=0.304N         P=0.531N         P=0.548N        |
|POLY 3             |        P=0.033N*        P=0.433N         P=0.041N*     |  P=0.302N         P=0.525N         P=0.536N        |
|POLY 1.5           |        P=0.038N*        P=0.455N         P=0.046N*     |  P=0.292N         P=0.518N         P=0.525N        |
|POLY 6             |        P=0.028N*        P=0.403N         P=0.035N*     |  P=0.309N         P=0.529N         P=0.543N        |
|LOGISTIC REGRESSION|        P=0.035N*        P=0.424N         P=0.052N      |  P=0.304N         (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.049N*        P=0.500N         P=0.056N      |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 39

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        3/50 (6%)     |  3/50 (6%)        4/50 (8%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        3.3%             8.7%             8.5%          |  6.9%             10.5%            2.8%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        2/24 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        603              720              565           |  493              562              536             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.331          P=0.465          P=0.411       |  P=0.348N         P=0.425          P=0.382N        |
|POLY 3             |        P=0.300          P=0.348          P=0.355       |  P=0.357N         P=0.428          P=0.375N        |
|POLY 1.5           |        P=0.275          P=0.333          P=0.335       |  P=0.323N         P=0.449          P=0.353N        |
|POLY 6             |        P=0.338          P=0.369          P=0.386       |  P=0.382N         P=0.414          P=0.391N        |
|LOGISTIC REGRESSION|        P=0.285          P=0.397          P=0.316       |  P=0.237N         P=0.510          P=0.207N        |
|COCH-ARM / FISHERS |        P=0.238          P=0.309          P=0.309       |  P=0.252N         P=0.500          P=0.309N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Red Pulp                                                                                                                 |
|     Depletion Cellular                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.5%             0.0%             2.9%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        521              ---              695           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.317N         P=0.186N         P=0.445N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.356N         P=0.212N         P=0.463N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.357N         P=0.221N         P=0.477N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.355N         P=0.200N         P=0.445N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.341N         P=0.234N         P=0.472N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.360N         P=0.247N         P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 40

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Edema                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       5/50 (10%)       8/50 (16%)    |  1/50 (2%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        17.8%            13.7%            21.5%         |  2.3%             2.6%             5.6%            |
|TERMINAL (d)       |        0/8 (0%)         1/12 (8%)        2/11 (18%)    |  0/28 (0%)        0/24 (0%)        2/22 (9%)       |
|FIRST INCIDENCE    |        334              474              329           |  655              280              728 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.455          P=0.396N         P=0.517       |  P=0.328          P=0.740          P=0.424         |
|POLY 3             |        P=0.388          P=0.444N         P=0.465       |  P=0.339          P=0.737          P=0.435         |
|POLY 1.5           |        P=0.367          P=0.462N         P=0.438       |  P=0.351          P=0.744          P=0.455         |
|POLY 6             |        P=0.412          P=0.420N         P=0.498       |  P=0.330          P=0.731          P=0.421         |
|LOGISTIC REGRESSION|        P=0.240          P=0.607N         P=0.288       |  P=0.438          P=0.577N         P=0.431         |
|COCH-ARM / FISHERS |        P=0.326          P=0.500N         P=0.387       |  P=0.378          P=0.753N         P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        15/50 (30%)      8/50 (16%)       14/50 (28%)   |  1/50 (2%)        3/50 (6%)        10/50 (20%)     |
|POLY-3 ADJUSTED (b)|        43.0%            21.7%            37.8%         |  2.3%             7.7%             27.1%           |
|TERMINAL (d)       |        3/8 (38%)        2/12 (17%)       3/11 (27%)    |  1/28 (4%)        1/24 (4%)        4/22 (18%)      |
|FIRST INCIDENCE    |        334              561              565           |  728 (T)          280              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.244N         P=0.028N*        P=0.257N      |  P<0.001 **       P=0.268          P=0.002 **      |
|POLY 3             |        P=0.391N         P=0.039N*        P=0.416N      |  P<0.001 **       P=0.275          P<0.001 **      |
|POLY 1.5           |        P=0.415N         P=0.050N         P=0.448N      |  P<0.001 **       P=0.283          P=0.002 **      |
|POLY 6             |        P=0.355N         P=0.026N*        P=0.363N      |  P<0.001 **       P=0.271          P<0.001 **      |
|LOGISTIC REGRESSION|        P=0.353N         P=0.053N         P=0.368N      |  P<0.001 **       P=0.437          P=0.002 **      |
|COCH-ARM / FISHERS |        P=0.454N         P=0.077N         P=0.500N      |  P=0.002 **       P=0.309          P=0.004 **      |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 41

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        2/50 (4%)        2/50 (4%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        12.6%            5.8%             5.7%          |  0.0%             2.6%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        593              708              656           |  ---              533              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.177N         P=0.244N         P=0.231N      |  P=0.704          P=0.478          (e)             |
|POLY 3             |        P=0.225N         P=0.294N         P=0.294N      |  P=0.698          P=0.478          (e)             |
|POLY 1.5           |        P=0.234N         P=0.307N         P=0.309N      |  P=0.708          P=0.484          (e)             |
|POLY 6             |        P=0.214N         P=0.282N         P=0.278N      |  P=0.691          P=0.476          (e)             |
|LOGISTIC REGRESSION|        P=0.216N         P=0.292N         P=0.315N      |  P=0.680N         P=0.612          (e)             |
|COCH-ARM / FISHERS |        P=0.252N         P=0.339N         P=0.339N      |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Perforation                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        2/50 (4%)        4/50 (8%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        12.9%            5.7%             11.4%         |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        1/12 (8%)        1/11 (9%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        589              561              565           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.476N         P=0.217N         P=0.524N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.536N         P=0.276N         P=0.573N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.552N         P=0.298N         P=0.601N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.515N         P=0.248N         P=0.535N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.503N         P=0.259N         P=0.545N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.579          P=0.339N         P=0.643N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 42

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        18/50 (36%)      16/50 (32%)      18/50 (36%)   |  2/50 (4%)        5/50 (10%)       13/50 (26%)     |
|POLY-3 ADJUSTED (b)|        51.1%            40.7%            45.5%         |  4.7%             12.7%            35.1%           |
|TERMINAL (d)       |        3/8 (38%)        4/12 (33%)       3/11 (27%)    |  2/28 (7%)        1/24 (4%)        6/22 (27%)      |
|FIRST INCIDENCE    |        334              558              329           |  728 (T)          280              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.282N         P=0.168N         P=0.299N      |  P<0.001 **       P=0.175          P<0.001 **      |
|POLY 3             |        P=0.374N         P=0.239N         P=0.394N      |  P<0.001 **       P=0.183          P<0.001 **      |
|POLY 1.5           |        P=0.434N         P=0.305N         P=0.465N      |  P<0.001 **       P=0.191          P<0.001 **      |
|POLY 6             |        P=0.306N         P=0.164N         P=0.309N      |  P<0.001 **       P=0.179          P<0.001 **      |
|LOGISTIC REGRESSION|        P=0.455N         P=0.297N         P=0.478N      |  P<0.001 **       P=0.252          P<0.001 **      |
|COCH-ARM / FISHERS |        P=0.542          P=0.417N         P=0.582N      |  P<0.001 **       P=0.218          P=0.002 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        13/50 (26%)      7/50 (14%)       13/50 (26%)   |  1/50 (2%)        3/50 (6%)        11/50 (22%)     |
|POLY-3 ADJUSTED (b)|        37.8%            19.2%            35.1%         |  2.3%             7.5%             29.8%           |
|TERMINAL (d)       |        3/8 (38%)        2/12 (17%)       2/11 (18%)    |  1/28 (4%)        0/24 (0%)        5/22 (23%)      |
|FIRST INCIDENCE    |        334              561              565           |  728 (T)          280              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.325N         P=0.039N*        P=0.335N      |  P<0.001 **       P=0.272          P<0.001 **      |
|POLY 3             |        P=0.486N         P=0.062N         P=0.504N      |  P<0.001 **       P=0.280          P<0.001 **      |
|POLY 1.5           |        P=0.511N         P=0.076N         P=0.539N      |  P<0.001 **       P=0.286          P<0.001 **      |
|POLY 6             |        P=0.443N         P=0.045N*        P=0.441N      |  P<0.001 **       P=0.279          P<0.001 **      |
|LOGISTIC REGRESSION|        P=0.459N         P=0.079N         P=0.480N      |  P<0.001 **       P=0.527          P<0.001 **      |
|COCH-ARM / FISHERS |        P=0.548          P=0.105N         P=0.590N      |  P<0.001 **       P=0.309          P=0.002 **      |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 43

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        3.3%             0.0%             5.7%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        677              ---              565           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.428          P=0.433N         P=0.591       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.386          P=0.474N         P=0.548       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.376          P=0.484N         P=0.529       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.399          P=0.462N         P=0.575       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.381          P=0.461N         P=0.534       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.360          P=0.500N         P=0.500       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/50 (14%)       6/50 (12%)       4/50 (8%)     |  0/50 (0%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        21.5%            17.0%            11.4%         |  0.0%             2.6%             2.8%            |
|TERMINAL (d)       |        0/8 (0%)         2/12 (17%)       0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        593              575              656           |  ---              562              715             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.115N         P=0.301N         P=0.139N      |  P=0.283          P=0.472          P=0.457         |
|POLY 3             |        P=0.169N         P=0.436N         P=0.210N      |  P=0.300          P=0.478          P=0.464         |
|POLY 1.5           |        P=0.184N         P=0.454N         P=0.227N      |  P=0.309          P=0.484          P=0.475         |
|POLY 6             |        P=0.156N         P=0.428N         P=0.196N      |  P=0.294          P=0.475          P=0.458         |
|LOGISTIC REGRESSION|        P=0.142N         P=0.382N         P=0.202N      |  P=0.335          P=0.583          P=0.455         |
|COCH-ARM / FISHERS |        P=0.215N         P=0.500N         P=0.262N      |  P=0.331          P=0.500          P=0.500         |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 44

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.8%          |  0.0%             2.7%             2.8%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              687           |  ---              708              672             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.119          (e)              P=0.312       |  P=0.284          P=0.473          P=0.455         |
|POLY 3             |        P=0.105          (e)              P=0.266       |  P=0.300          P=0.476          P=0.465         |
|POLY 1.5           |        P=0.101          (e)              P=0.255       |  P=0.310          P=0.482          P=0.476         |
|POLY 6             |        P=0.111          (e)              P=0.284       |  P=0.295          P=0.472          P=0.459         |
|LOGISTIC REGRESSION|        P=0.111          (e)              P=0.291       |  P=0.298          P=0.472          P=0.483         |
|COCH-ARM / FISHERS |        P=0.095          (e)              P=0.247       |  P=0.331          P=0.500          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        3/50 (6%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             8.5%          |  2.3%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              565           |  493              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.053          (e)              P=0.181       |  P=0.299N         P=0.526N         P=0.540N        |
|POLY 3             |        P=0.041 *        (e)              P=0.145       |  P=0.306N         P=0.528N         P=0.539N        |
|POLY 1.5           |        P=0.039 *        (e)              P=0.134       |  P=0.294N         P=0.520N         P=0.527N        |
|POLY 6             |        P=0.045 *        (e)              P=0.164       |  P=0.314N         P=0.534N         P=0.547N        |
|LOGISTIC REGRESSION|        P=0.040 *        (e)              P=0.138       |  P=0.166N         P=0.346N         P=0.325N        |
|COCH-ARM / FISHERS |        P=0.037 *        (e)              P=0.121       |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 45

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Arteriole                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        9/50 (18%)       11/50 (22%)      13/50 (26%)   |                                                    |
|POLY-3 ADJUSTED (b)|        27.9%            29.9%            35.5%         |                                                    |
|TERMINAL (d)       |        3/8 (38%)        3/12 (25%)       5/11 (46%)    |                                                    |
|FIRST INCIDENCE    |        603              561              607           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.439          P=0.516N         P=0.510       |                                                    |
|POLY 3             |        P=0.285          P=0.534          P=0.333       |                                                    |
|POLY 1.5           |        P=0.251          P=0.484          P=0.292       |                                                    |
|POLY 6             |        P=0.336          P=0.600          P=0.396       |                                                    |
|LOGISTIC REGRESSION|        P=0.326          P=0.568          P=0.390       |                                                    |
|COCH-ARM / FISHERS |        P=0.199          P=0.402          P=0.235       |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Arteriole                                                                                                                |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        9/50 (18%)       10/50 (20%)      13/50 (26%)   |                                                    |
|POLY-3 ADJUSTED (b)|        27.9%            27.2%            35.5%         |                                                    |
|TERMINAL (d)       |        3/8 (38%)        3/12 (25%)       5/11 (46%)    |                                                    |
|FIRST INCIDENCE    |        603              561              607           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.433          P=0.444N         P=0.510       |                                                    |
|POLY 3             |        P=0.276          P=0.584N         P=0.333       |                                                    |
|POLY 1.5           |        P=0.244          P=0.584          P=0.292       |                                                    |
|POLY 6             |        P=0.322          P=0.528N         P=0.396       |                                                    |
|LOGISTIC REGRESSION|        P=0.316          P=0.553N         P=0.390       |                                                    |
|COCH-ARM / FISHERS |        P=0.196          P=0.500          P=0.235       |                                                    |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 46

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      15/50 (30%)      17/50 (34%)   |                                                    |
|POLY-3 ADJUSTED (b)|        34.1%            39.9%            44.7%         |                                                    |
|TERMINAL (d)       |        5/8 (63%)        4/12 (33%)       4/11 (36%)    |                                                    |
|FIRST INCIDENCE    |        540              474              389           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.345          P=0.572N         P=0.396       |                                                    |
|POLY 3             |        P=0.212          P=0.398          P=0.244       |                                                    |
|POLY 1.5           |        P=0.167          P=0.336          P=0.192       |                                                    |
|POLY 6             |        P=0.295          P=0.496          P=0.340       |                                                    |
|LOGISTIC REGRESSION|        P=0.207          P=0.422          P=0.250       |                                                    |
|COCH-ARM / FISHERS |        P=0.112          P=0.247          P=0.133       |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        12/50 (24%)      12/50 (24%)      13/50 (26%)   |                                                    |
|POLY-3 ADJUSTED (b)|        34.9%            31.4%            33.7%         |                                                    |
|TERMINAL (d)       |        2/8 (25%)        2/12 (17%)       2/11 (18%)    |                                                    |
|FIRST INCIDENCE    |        470              495              474           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.402N         P=0.337N         P=0.435N      |                                                    |
|POLY 3             |        P=0.517N         P=0.474N         P=0.556N      |                                                    |
|POLY 1.5           |        P=0.538          P=0.515N         P=0.589       |                                                    |
|POLY 6             |        P=0.460N         P=0.422N         P=0.493N      |                                                    |
|LOGISTIC REGRESSION|        P=0.492          P=0.534N         P=0.543       |                                                    |
|COCH-ARM / FISHERS |        P=0.454          P=0.592N         P=0.500       |                                                    |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 47

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       11/50 (22%)      11/50 (22%)   |  17/50 (34%)      7/50 (14%)       7/50 (14%)      |
|POLY-3 ADJUSTED (b)|        19.0%            28.7%            30.2%         |  39.5%            17.8%            19.5%           |
|TERMINAL (d)       |        2/8 (25%)        3/12 (25%)       3/11 (27%)    |  15/28 (54%)      4/24 (17%)       5/22 (23%)      |
|FIRST INCIDENCE    |        593              474              485           |  619              476              626             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.300          P=0.319          P=0.357       |  P=0.037N*        P=0.042N*        P=0.062N        |
|POLY 3             |        P=0.195          P=0.252          P=0.211       |  P=0.019N*        P=0.024N*        P=0.043N*       |
|POLY 1.5           |        P=0.166          P=0.204          P=0.182       |  P=0.015N*        P=0.023N*        P=0.032N*       |
|POLY 6             |        P=0.238          P=0.330          P=0.257       |  P=0.021N*        P=0.023N*        P=0.049N*       |
|LOGISTIC REGRESSION|        P=0.172          P=0.181          P=0.234       |  P=0.030N*        P=0.036N*        P=0.055N        |
|COCH-ARM / FISHERS |        P=0.124          P=0.143          P=0.143       |  P=0.009N**       P=0.017N*        P=0.017N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicle                                                                                                          |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.5%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/8 (13%)        0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        442              ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.076N         P=0.189N         P=0.203N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.093N         P=0.212N         P=0.214N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.094N         P=0.221N         P=0.223N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.093N         P=0.199N         P=0.202N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.105N         P=0.253N         P=0.250N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  01/28/99                           EXPERIMENT: 55312 TEST: 03                                            Page 48

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.4%             2.9%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        0/11 (0%)     |  0/28 (0%)        0/24 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        563              656              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.114N         P=0.438N         P=0.221N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.131N         P=0.462N         P=0.216N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.135N         P=0.475N         P=0.223N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.127N         P=0.445N         P=0.207N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.150N         P=0.515N         P=0.257N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.142N         P=0.500N         P=0.247N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder: Transitional Epithelium                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        3.3%             0.0%             2.9%          |  0.0%             2.7%             5.5%            |
|TERMINAL (d)       |        0/8 (0%)         0/12 (0%)        1/11 (9%)     |  0/28 (0%)        1/24 (4%)        1/22 (5%)       |
|FIRST INCIDENCE    |        618              ---              729 (T)       |  ---              728 (T)          588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.616N         P=0.477N         P=0.700N      |  P=0.109          P=0.469          P=0.188         |
|POLY 3             |        P=0.668N         P=0.476N         P=0.736N      |  P=0.122          P=0.475          P=0.202         |
|POLY 1.5           |        P=0.667N         P=0.484N         P=0.745N      |  P=0.128          P=0.482          P=0.212         |
|POLY 6             |        P=0.670N         P=0.464N         P=0.725N      |  P=0.119          P=0.471          P=0.196         |
|LOGISTIC REGRESSION|        P=0.637N         P=0.497N         P=0.725N      |  P=0.121          P=0.469          P=0.225         |
|COCH-ARM / FISHERS |        P=0.669          P=0.500N         P=0.753N      |  P=0.142          P=0.500          P=0.247         |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).