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TDMS Study 55312-04 Pathology Tables

NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97
Route: SKIN APPLICATION                                                                                           Time: 08:14:59

                                                         2 YEAR CHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  68603-42-9

       Lock Date:  09/06/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           11           15                                                  
    Natural Death                                      4            3            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           35           26                                                  
    Natural Death                                                   1                                                               

  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
      Inflammation                                                  1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (50)         (50)                                                
      Hemorrhage                                       1 (2%)                                                                       
   Intestine Small, Duodenum                          (50)         (50)         (50)                                                
      Erosion                                                                    2 (4%)                                             
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (49)         (50)         (50)                                                
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
      Inflammation                                                               1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
      Mucosa, Hyperplasia                                           1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Basophilic Focus                                 2 (4%)                                                                       
      Clear Cell Focus                                 2 (4%)       2 (4%)       2 (4%)                                             
      Eosinophilic Focus                              18 (36%)     25 (50%)     24 (48%)                                            
      Fibrosis                                         2 (4%)       1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mixed Cell Focus                                 1 (2%)       5 (10%)                                                         
      Necrosis                                         2 (4%)       5 (10%)      8 (16%)                                            
      Bile Duct, Hyperplasia                           1 (2%)       1 (2%)                                                          
   Mesentery                                          (12)         (9)          (8)                                                 
      Fat, Inflammation                                2 (17%)                                                                      
      Fat, Necrosis                                    9 (75%)      8 (89%)      7 (88%)                                            
   Pancreas                                           (50)         (50)         (50)                                                
      Atrophy                                          1 (2%)       4 (8%)       1 (2%)                                             
      Hypertrophy                                                                1 (2%)                                             
      Hypertrophy, Focal                               3 (6%)       1 (2%)       1 (2%)                                             
      Duct, Cyst                                       2 (4%)       1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Erosion                                                       1 (2%)       1 (2%)                                             
      Hyperplasia, Focal                               2 (4%)       2 (4%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation                                                  1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Erosion                                          1 (2%)                    2 (4%)                                             
      Inflammation                                     2 (4%)                                                                       
      Mineralization                                   2 (4%)       1 (2%)       1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
   Tooth                                                           (1)                                                              
      Inflammation                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
      Mineralization                                   1 (2%)       1 (2%)       1 (2%)                                             
      Artery, Inflammation                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Hypertrophy                                      1 (2%)                                                                       
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
      Capsule, Hyperplasia                                          2 (4%)                                                          
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Hyperplasia                                      2 (4%)       1 (2%)       2 (4%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
   Parathyroid Gland                                  (37)         (42)         (43)                                                
      Cyst                                             1 (3%)                                                                       
      Hyperplasia, Focal                                            1 (2%)                                                          
   Pituitary Gland                                    (48)         (50)         (49)                                                
      Angiectasis                                      1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      28 (58%)     31 (62%)     27 (55%)                                            
      Pars Intermedia, Hyperplasia                                  1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Follicular Cell, Hyperplasia                    27 (54%)     36 (72%)     33 (66%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (47)                                                
      Inflammation                                     1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)                                                
      Angiectasis                                                   2 (4%)                                                          
      Cyst                                            15 (30%)     14 (28%)     15 (30%)                                            
      Hemorrhage                                       2 (4%)                    2 (4%)                                             
      Mineralization                                   1 (2%)                                                                       
      Granulosa Cell, Hyperplasia                                   1 (2%)       1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Decidual Reaction                                1 (2%)                                                                       
      Hyperplasia                                     37 (74%)     26 (52%)     22 (44%)                                            
      Inflammation, Suppurative                                     1 (2%)                                                          
      Thrombosis                                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                      7 (14%)     10 (20%)     19 (38%)                                            
      Myelofibrosis                                   21 (42%)     21 (42%)     19 (38%)                                            
   Lymph Node                                         (7)          (3)          (6)                                                 
      Inguinal, Hematopoietic Cell Proliferation                                 1 (17%)                                            
      Mediastinal, Hematopoietic Cell Proliferation                              1 (17%)                                            
      Renal, Hematopoietic Cell Proliferation                                    1 (17%)                                            
   Lymph Node, Mandibular                             (49)         (47)         (49)                                                
      Hematopoietic Cell Proliferation                                           2 (4%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (50)         (49)                                                
      Angiectasis                                                   1 (2%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                    2 (4%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Inflammation                                                               1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Accessory Spleen                                              1 (2%)                                                          
      Hematopoietic Cell Proliferation                33 (66%)     33 (66%)     36 (72%)                                            
      Lymphoid Follicle, Hyperplasia                   1 (2%)       5 (10%)                                                         
   Thymus                                             (47)         (40)         (41)                                                
      Atrophy                                          7 (15%)      4 (10%)      8 (20%)                                            
      Hyperplasia, Lymphoid                            1 (2%)       2 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Control, Edema                                   1 (2%)                                                                       
      Control, Hyperkeratosis                          1 (2%)                                                                       
      Control, Inflammation                                                      3 (6%)                                             
      Control, Parakeratosis                           1 (2%)                                                                       
      Epidermis, Control, Hyperplasia                  1 (2%)                                                                       
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                  9 (18%)     47 (94%)     50 (100%)                                           
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                             42 (84%)     48 (96%)                                            
      Skin, Site of Application, Hyperkeratosis        5 (10%)     30 (60%)     40 (80%)                                            
      Skin, Site of Application, Inflammation          3 (6%)       2 (4%)      11 (22%)                                            
      Skin, Site of Application, Parakeratosis         3 (6%)       4 (8%)      16 (32%)                                            
      Skin, Site of Application, Ulcer                 1 (2%)                    3 (6%)                                             
      Subcutaneous Tissue, Control, Hemorrhage                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteomalacia                                                  1 (2%)                                                          
      Joint, Inflammation, Chronic                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Neuron, Necrosis                                              2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Inflammation                                                  2 (4%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)       2 (4%)                                             
   Nose                                               (50)         (50)         (49)                                                
      Inflammation                                                  1 (2%)       2 (4%)                                             
      Nasolacrimal Duct, Inflammation                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (1)                                                 
      Degeneration                                                  1 (50%)                                                         
      Cornea, Inflammation                             1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Accumulation, Hyaline Droplet                    2 (4%)                    1 (2%)                                             
      Cyst                                                                       1 (2%)                                             
      Hydronephrosis                                   1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                   2 (4%)                                                                       
      Nephropathy                                     27 (54%)     24 (48%)     15 (30%)                                            
      Pigmentation, Hemosiderin                        1 (2%)                    2 (4%)                                             
      Pigmentation, Hemoglobin                                      1 (2%)                                                          
      Glomerulus, Thrombosis                                                     1 (2%)                                             
      Renal Tubule, Degeneration                                    1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Inflammation                                     1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            7            7                                                  
    Natural Death                                      4            6            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           37           36                                                  

  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (50)         (50)                                                
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (50)         (50)         (50)                                                
      Inflammation                                                  1 (2%)                                                          
      Lymphatic, Hyperplasia                                        1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                              3 (6%)                                                          
      Clear Cell Focus                                 8 (16%)      8 (16%)      4 (8%)                                             
      Degeneration, Cystic                             1 (2%)                                                                       
      Eosinophilic Focus                              20 (40%)     29 (58%)     31 (62%)                                            
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                                             
      Mixed Cell Focus                                 6 (12%)      7 (14%)      6 (12%)                                            
      Necrosis                                         1 (2%)       3 (6%)       2 (4%)                                             
      Bile Duct, Hyperplasia                                                     1 (2%)                                             
   Mesentery                                          (3)          (3)          (4)                                                 
      Artery, Inflammation                                                       1 (25%)                                            
      Fat, Necrosis                                    1 (33%)      1 (33%)      2 (50%)                                            
   Pancreas                                           (50)         (50)         (50)                                                
      Atrophy                                          2 (4%)       2 (4%)       5 (10%)                                            
      Hypertrophy, Focal                                                         1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Duct, Cyst                                                    1 (2%)       1 (2%)                                             
      Duct, Hyperplasia                                                          1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)                                                
      Inflammation                                                  1 (2%)                                                          
      Inflammation, Granulomatous                                                1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Dysplasia                                                     1 (2%)                                                          
      Erosion                                          1 (2%)                                                                       
      Hyperplasia                                                   1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Granulomatous                                                1 (2%)                                             
   Tooth                                                           (1)                                                              
      Inflammation                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)                                                
      Aorta, Inflammation                              1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)                                                
      Degeneration                                                  3 (6%)                                                          
      Artery, Inflammation                                          1 (2%)                                                          
      Atrium, Thrombosis                                                         1 (2%)                                             
      Coronary Artery, Thrombosis                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia                                      3 (6%)       6 (12%)      3 (6%)                                             
      Hypertrophy                                     28 (56%)     30 (60%)     26 (52%)                                            
      Necrosis                                                      1 (2%)                                                          
      Capsule, Hyperplasia                             8 (16%)     15 (30%)     11 (22%)                                            
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Hyperplasia                                      2 (4%)       2 (4%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Hyperplasia                                     21 (42%)     23 (46%)     21 (42%)                                            
   Pituitary Gland                                    (45)         (47)         (49)                                                
      Cyst                                             2 (4%)       3 (6%)                                                          
      Pars Distalis, Hyperplasia                       4 (9%)       2 (4%)       4 (8%)                                             
      Pars Intermedia, Hyperplasia                                  1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Follicular Cell, Hyperplasia                    11 (22%)     20 (40%)     23 (46%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Granuloma Sperm                                  2 (4%)       1 (2%)       2 (4%)                                             
   Penis                                                                        (1)                                                 
      Congestion                                                                 1 (100%)                                           

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Preputial Gland                                    (49)         (50)         (50)                                                
      Cyst                                            21 (43%)     21 (42%)     14 (28%)                                            
      Inflammation                                     1 (2%)                    1 (2%)                                             
   Prostate                                           (50)         (50)         (50)                                                
      Inflammation                                     1 (2%)                    1 (2%)                                             
   Seminal Vesicle                                    (50)         (49)         (50)                                                
      Inflammation, Granulomatous                                                1 (2%)                                             
   Testes                                             (50)         (50)         (50)                                                
      Atrophy                                          2 (4%)       2 (4%)       1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                     10 (20%)     10 (20%)     19 (38%)                                            
   Lymph Node, Mandibular                             (47)         (45)         (44)                                                
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
   Lymph Node, Mesenteric                             (46)         (48)         (47)                                                
      Angiectasis                                      1 (2%)       1 (2%)       1 (2%)                                             
      Atrophy                                                                    2 (4%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)       3 (6%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                25 (50%)     23 (46%)     30 (60%)                                            
   Thymus                                             (43)         (44)         (41)                                                
      Atrophy                                         13 (30%)     13 (30%)     14 (34%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Control, Edema                                                1 (2%)                                                          
      Control, Infiltration Cellular, Mast Cell        1 (2%)                                                                       
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                  5 (10%)     47 (94%)     50 (100%)                                           
      Lymphatic, Angiectasis                                        1 (2%)                                                          
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                             44 (88%)     49 (98%)                                            
      Skin, Site of Application, Hyperkeratosis                    24 (48%)     23 (46%)                                            
      Skin, Site of Application, Inflammation          2 (4%)       2 (4%)       2 (4%)                                             
      Skin, Site of Application, Parakeratosis         1 (2%)       4 (8%)       5 (10%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Skin, Site of Application, Ulcer                 1 (2%)                    7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Hyperostosis                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Neuron, Necrosis                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 4 (8%)       4 (8%)       1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Nasolacrimal Duct, Inflammation                  1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (1)                                                 
      Cornea, Inflammation                                          2 (100%)     1 (100%)                                           
   Harderian Gland                                    (3)          (3)          (6)                                                 
      Hyperplasia                                      1 (33%)                   1 (17%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Accumulation, Hyaline Droplet                    1 (2%)       1 (2%)                                                          
      Cyst                                            12 (24%)     16 (32%)     11 (22%)                                            
      Inflammation, Granulomatous                                                1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Nephropathy                                     47 (94%)     49 (98%)     50 (100%)                                           
      Pigmentation, Hemosiderin                                                  3 (6%)                                             
      Artery, Inflammation                             2 (4%)                    1 (2%)                                             
      Renal Tubule, Hyperplasia                        1 (2%)                    2 (4%)                                             
   Ureter                                             (1)                       (1)                                                 

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 55312-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:14:59  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Granulomatous                                                1 (100%)                                           
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Inflammation                                                               1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
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