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TDMS Study 55312-04 Pathology Tables

NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97
Route: SKIN APPLICATION                                                                                           Time: 08:19:06

                                                         2 YEAR CHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  68603-42-9

       Lock Date:  09/06/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           11           15                                                  
    Natural Death                                      4            3            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           35           26                                                  
    Natural Death                                                   1                                                               

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (49)         (48)         (50)                                                
   Intestine Large, Rectum                            (50)         (50)         (50)                                                
   Intestine Small, Duodenum                          (50)         (50)         (50)                                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (2%)                                                          
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (50)         (50)                                                
      Carcinoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                                1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatoblastoma                                                1 (2%)       2 (4%)                                             
      Hepatoblastoma, Multiple                                                   1 (2%)                                             
      Hepatocellular Carcinoma                         1 (2%)      17 (34%)     16 (32%)                                            
      Hepatocellular Carcinoma, Multiple               2 (4%)       4 (8%)      16 (32%)                                            
      Hepatocellular Adenoma                           8 (16%)      5 (10%)      5 (10%)                                            
      Hepatocellular Adenoma, Multiple                24 (48%)     39 (78%)     38 (76%)                                            
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (2%)                                                          
   Mesentery                                          (12)         (9)          (8)                                                 
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (11%)                                                         
   Pancreas                                           (50)         (50)         (50)                                                
      Hemangioma                                                    1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma                          1 (2%)       2 (4%)       1 (2%)                                             

                                                             Page   2                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Glandular                                 (50)         (50)         (50)                                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Complex                                                   1 (2%)                                             
      Pheochromocytoma Benign                          2 (4%)       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (48)         (50)         (49)                                                
      Pars Distalis, Adenoma                           5 (10%)      2 (4%)       1 (2%)                                             
      Pars Distalis, Carcinoma                         1 (2%)       1 (2%)                                                          
      Pars Intermedia, Adenoma                                      1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         2 (4%)       5 (10%)      3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (47)                                                
      Carcinoma                                                     1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)                                                
      Cystadenoma                                      3 (6%)                    1 (2%)                                             
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Luteoma                                          1 (2%)                                                                       

                                                             Page   3                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Teratoma Benign                                                            1 (2%)                                             
      Teratoma Malignant                                                         1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                    1 (2%)       2 (4%)       2 (4%)                                             
   Vagina                                                          (1)                                                              
      Histiocytic Sarcoma                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Metastatic, Ovary                                         1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (7)          (3)          (6)                                                 
      Bronchial, Histiocytic Sarcoma                                1 (33%)                                                         
      Inguinal, Fibrosarcoma, Metastatic, Skin         1 (14%)                                                                      
      Lumbar, Histiocytic Sarcoma                                                1 (17%)                                            
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (17%)                                            
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                        1 (14%)                                                                      
      Mediastinal, Hepatoblastoma, Metastatic,                                                                                      
           Liver                                                    1 (33%)                                                         
      Mediastinal, Histiocytic Sarcoma                              1 (33%)      1 (17%)                                            
      Pancreatic, Carcinoma, Metastatic, Thyroid                                                                                    
          Gland                                        1 (14%)                                                                      
   Lymph Node, Mandibular                             (49)         (47)         (49)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (48)         (50)         (49)                                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (2%)                                                          
   Thymus                                             (47)         (40)         (41)                                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (50)                                                
      Carcinoma                                        1 (2%)                    1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Melanoma Benign                                                            1 (2%)                                             
      Melanoma Malignant                                                         1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Melanoma Benign             1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Control, Sarcoma            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       3 (6%)                                                          
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       2 (4%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                             1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       3 (6%)       9 (18%)                                            
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Mediastinum, Leiomyosarcoma, Metastatic,                                                                                      
           Intestine Small, Jejunum                                 1 (2%)                                                          
   Nose                                               (50)         (50)         (49)                                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (1)                                                 
      Carcinoma, Metastatic, Harderian Gland                        1 (50%)                                                         
   Harderian Gland                                    (1)          (2)          (1)                                                 
      Carcinoma                                        1 (100%)     2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________

                                                             Page   5                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Hepatoblastoma, Metastatic, Liver                             1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (2%)                                                          
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Hemangioma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)       2 (4%)       1 (2%)                                             
      Lymphoma Malignant                              13 (26%)      5 (10%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          48          50                                                   
     Total Primary Neoplasms                           78         104         110                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          45          45                                                   
     Total Benign Neoplasms                            53          66          56                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          30          41                                                   
     Total Malignant Neoplasms                         25          38          54                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           8          11                                                   
     Total Metastatic Neoplasm                         11          21          12                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            7            7                                                  
    Natural Death                                      4            6            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           37           36                                                  

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)                                                
   Intestine Large, Cecum                             (50)         (50)         (50)                                                
   Intestine Small, Duodenum                          (49)         (50)         (50)                                                
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)       2 (4%)                                                          
      Hemangiosarcoma, Multiple                        1 (2%)                    1 (2%)                                             
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                    1 (2%)                                             
      Hepatoblastoma                                                1 (2%)      10 (20%)                                            
      Hepatoblastoma, Multiple                         1 (2%)                                                                       
      Hepatocellular Carcinoma                         7 (14%)     10 (20%)     12 (24%)                                            
      Hepatocellular Carcinoma, Multiple               5 (10%)      2 (4%)       8 (16%)                                            
      Hepatocellular Adenoma                          11 (22%)     11 (22%)      4 (8%)                                             
      Hepatocellular Adenoma, Multiple                11 (22%)     24 (48%)     41 (82%)                                            
      Histiocytic Sarcoma                              1 (2%)       2 (4%)                                                          
      Mast Cell Tumor Malignant, Metastatic, Skin                                1 (2%)                                             
   Mesentery                                          (3)          (3)          (4)                                                 
      Hepatoblastoma, Metastatic, Liver                1 (33%)                                                                      
      Hepatoblastoma, Metastatic, Pancreas                                       1 (25%)                                            
      Histiocytic Sarcoma                              1 (33%)      1 (33%)                                                         
   Oral Mucosa                                                     (1)                                                              
      Gingival, Squamous Cell Carcinoma                             1 (100%)                                                        
   Pancreas                                           (50)         (50)         (50)                                                
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Pancreas                                       1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Hemangioma                                                                 1 (2%)                                             

                                                             Page   8                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                                                    2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (45)         (47)         (49)                                                
      Pars Distalis, Adenoma                                                     1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                                 (1)                                                              
   Epididymis                                         (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Preputial Gland                                    (49)         (50)         (50)                                                
   Prostate                                           (50)         (50)         (50)                                                
   Seminal Vesicle                                    (50)         (49)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hemangiosarcoma, Metastatic, Liver               1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (2)          (5)          (1)                                                 
      Lumbar, Alveolar/Bronchiolar Carcinoma,                                                                                       
          Metastatic, Lung                                          1 (20%)                                                         
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (20%)                                                         
      Mediastinal, Histiocytic Sarcoma                              1 (20%)                                                         
   Lymph Node, Mandibular                             (47)         (45)         (44)                                                
   Lymph Node, Mesenteric                             (46)         (48)         (47)                                                
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                  3 (6%)                    1 (2%)                                             
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
   Thymus                                             (43)         (44)         (41)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Melanoma Malignant                                                         1 (2%)                                             
      Skin, Site of Application, Mast Cell Tumor                                                                                    
          Malignant                                                              1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Vertebra, Osteosarcoma                                                     1 (2%)                                             
   Skeletal Muscle                                                 (1)          (3)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)                                                        
      Hepatoblastoma, Metastatic, Pancreas                                       1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                    10 (20%)      7 (14%)      6 (12%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       3 (6%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       2 (4%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)       5 (10%)      2 (4%)                                             
      Hepatoblastoma, Metastatic, Liver                1 (2%)                    3 (6%)                                             
      Hepatoblastoma, Metastatic, Pancreas                                       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      2 (4%)       4 (8%)                                             
      Histiocytic Sarcoma                                           2 (4%)                                                          
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Serosa, Alveolar/Bronchiolar Carcinoma,                                                                                       
          Metastatic, Lung                                          1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (1)                                                 
      Sarcoma                                          1 (100%)                                                                     
   Harderian Gland                                    (3)          (3)          (6)                                                 
      Adenoma                                          2 (67%)                                                                      
      Carcinoma                                                     2 (67%)      3 (50%)                                            
      Bilateral, Carcinoma                                          1 (33%)      1 (17%)                                            
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mast Cell Tumor Malignant, Metastatic, Skin                                1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)       7 (14%)                                            
      Renal Tubule, Carcinoma                                                    2 (4%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                

                                                             Page  11                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)       2 (4%)                                                          
      Lymphoma Malignant                               2 (4%)       3 (6%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  12                                                               
NTP Experiment-Test: 55312-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                        Date: 09/18/97  
Route: SKIN APPLICATION                                                                                           Time: 08:19:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          45          50                                                   
     Total Primary Neoplasms                           65          80         113                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26          39          47                                                   
     Total Benign Neoplasms                            38          49          65                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          28          35                                                   
     Total Malignant Neoplasms                         27          31          48                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              9           3          12                                                   
     Total Metastatic Neoplasm                         17           9          16                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

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