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TDMS Study 55312-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Columbus                         COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                      DATE: 09/26/97

EXPERIMENT: 55312 TEST: 04                                                                                     TIME: 10:39:02
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55312B
PATHOLOGIST: SINGER, A.                                                                                        CAS: 68603-42-9
            

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                         COCONUT OIL ACID DIETHANOLAMINE CONDENSATE                      DATE: 09/26/97     
EXPERIMENT: 55312 TEST: 04                                                                                     TIME: 10:39:02     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55312B     
PATHOLOGIST: SINGER, A.                                                                                        CAS: 68603-42-9    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF    COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex: Capsule                Hyperplasia
Bone Marrow                            Hyperplasia
Kidney                                 Nephropathy
                                       Pigmentation Hemosiderin
Liver                                  Eosinophilic Focus
Skin: Epidermis, Skin, Site of Application
                                       Hyperplasia
Skin: Sebaceous Gland, Skin, Site of Application
                                       Hyperplasia
Skin: Skin, Site of Application        Hyperkeratosis
                                       Ulcer
Thyroid Gland: Follicular Cell         Hyperplasia
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Bone Marrow                            Hyperplasia
Kidney                                 Nephropathy
Liver                                  Eosinophilic Focus
                                       Necrosis
Skin: Control                          Inflammation
Skin: Epidermis, Skin, Site of Application
                                       Hyperplasia
Skin: Sebaceous Gland, Skin, Site of Application
                                       Hyperplasia
Skin: Skin, Site of Application        Hyperkeratosis
                                       Inflammation
                                       Parakeratosis
Spleen                                 Hematopoietic Cell Proliferation
Thyroid Gland: Follicular Cell         Hyperplasia
Uterus                                 Hyperplasia
===============================================================
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 1

Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        6/50 (12%)       3/50 (6%)     |  0/50 (0%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        6.5%             13.5%            6.7%          |  0.0%             2.2%             2.5%            |
|TERMINAL (d)       |        3/41 (7%)        5/37 (14%)       3/36 (8%)     |  0/35 (0%)        1/36 (3%)        1/26 (4%)       |
|FIRST INCIDENCE    |        727 (T)          711              727 (T)       |  ---              729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.499          P=0.197          P=0.602       |  P=0.268          P=0.506          P=0.441         |
|POLY 3             |        P=0.553          P=0.222          P=0.649       |  P=0.314          P=0.496          P=0.479         |
|POLY 1.5           |        P=0.561          P=0.228          P=0.654       |  P=0.320          P=0.498          P=0.486         |
|POLY 6             |        P=0.544          P=0.216          P=0.643       |  P=0.305          P=0.492          P=0.468         |
|LOGISTIC REGRESSION|        P=0.532          P=0.204          P=0.602       |  (e)              P=0.506          P=0.441         |
|COCH-ARM / FISHERS |        P=0.573          P=0.243          P=0.661N      |  P=0.331          P=0.500          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        28/50 (56%)      30/50 (60%)      26/50 (52%)   |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        59.5%            66.0%            56.0%         |  2.2%             0.0%             0.0%            |
|TERMINAL (d)       |        27/41 (66%)      27/37 (73%)      21/36 (58%)   |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        490              507              555           |  701              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.426          P=0.199          P=0.482       |  P=0.304N         P=0.521N         P=0.551N        |
|POLY 3             |        P=0.405N         P=0.329          P=0.446N      |  P=0.289N         P=0.504N         P=0.522N        |
|POLY 1.5           |        P=0.401N         P=0.354          P=0.441N      |  P=0.282N         P=0.502N         P=0.514N        |
|POLY 6             |        P=0.396N         P=0.313          P=0.438N      |  P=0.299N         P=0.509N         P=0.533N        |
|LOGISTIC REGRESSION|        P=0.451N         P=0.304          P=0.486N      |  P=0.276N         P=0.501N         P=0.516N        |
|COCH-ARM / FISHERS |        P=0.381N         P=0.420          P=0.421N      |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 2

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex: Capsule                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       15/50 (30%)      11/50 (22%)   |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        17.3%            33.0%            24.3%         |  0.0%             4.5%             0.0%            |
|TERMINAL (d)       |        8/41 (20%)       13/37 (35%)      10/36 (28%)   |  0/35 (0%)        1/36 (3%)        0/26 (0%)       |
|FIRST INCIDENCE    |        727 (T)          507              692           |  ---              649              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.175          P=0.045 *        P=0.205       |  P=0.621          P=0.232          (e)             |
|POLY 3             |        P=0.245          P=0.065          P=0.282       |  P=0.632          P=0.234          (e)             |
|POLY 1.5           |        P=0.256          P=0.067          P=0.291       |  P=0.645          P=0.236          (e)             |
|POLY 6             |        P=0.233          P=0.063          P=0.272       |  P=0.611          P=0.231          (e)             |
|LOGISTIC REGRESSION|        P=0.243          P=0.061          P=0.249       |  P=0.668          P=0.239          (e)             |
|COCH-ARM / FISHERS |        P=0.275          P=0.077          P=0.306       |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        0/50 (0%)     |  2/50 (4%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        4.3%             4.5%             0.0%          |  4.4%             2.2%             4.9%            |
|TERMINAL (d)       |        2/41 (5%)        2/37 (5%)        0/36 (0%)     |  1/35 (3%)        1/36 (3%)        1/26 (4%)       |
|FIRST INCIDENCE    |        727 (T)          727 (T)          ---           |  702              729 (T)          672             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.207N         P=0.658          P=0.267N      |  P=0.509          P=0.503N         P=0.586         |
|POLY 3             |        P=0.185N         P=0.678          P=0.244N      |  P=0.586          P=0.507N         P=0.656         |
|POLY 1.5           |        P=0.182N         P=0.683          P=0.241N      |  P=0.594          P=0.503N         P=0.670         |
|POLY 6             |        P=0.189N         P=0.674          P=0.247N      |  P=0.575          P=0.515N         P=0.637         |
|LOGISTIC REGRESSION|        P=0.207N         P=0.658          (e)           |  P=0.562          P=0.515N         P=0.655         |
|COCH-ARM / FISHERS |        P=0.176N         P=0.691N         P=0.247N      |  P=0.610          P=0.500N         P=0.691N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 3

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        10/50 (20%)      10/50 (20%)      19/50 (38%)   |  7/50 (14%)       10/50 (20%)      19/50 (38%)     |
|POLY-3 ADJUSTED (b)|        20.9%            21.7%            40.4%         |  15.0%            21.6%            43.9%           |
|TERMINAL (d)       |        5/41 (12%)       5/37 (14%)       12/36 (33%)   |  1/35 (3%)        6/36 (17%)       10/26 (39%)     |
|FIRST INCIDENCE    |        584              454              401           |  506              473              506             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.023 *        P=0.519          P=0.031 *     |  P<0.001 **       P=0.304          P=0.002 **      |
|POLY 3             |        P=0.021 *        P=0.562          P=0.031 *     |  P<0.001 **       P=0.289          P=0.002 **      |
|POLY 1.5           |        P=0.023 *        P=0.573          P=0.034 *     |  P=0.002 **       P=0.295          P=0.002 **      |
|POLY 6             |        P=0.019 *        P=0.550          P=0.028 *     |  P<0.001 **       P=0.276          P<0.001 **      |
|LOGISTIC REGRESSION|        P=0.028 *        P=0.563N         P=0.043 *     |  P=0.004 **       P=0.302          P=0.005 **      |
|COCH-ARM / FISHERS |        P=0.026 *        P=0.598N         P=0.038 *     |  P=0.004 **       P=0.298          P=0.006 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Myelofibrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  21/50 (42%)      21/50 (42%)      19/50 (38%)     |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  45.3%            47.0%            44.9%           |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  15/35 (43%)      20/36 (56%)      13/26 (50%)     |
|FIRST INCIDENCE    |        ---              ---              ---           |  589              680              610             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.277          P=0.561N         P=0.322         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.536N         P=0.518          P=0.572N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.479N         P=0.551          P=0.518N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.478          P=0.459          P=0.528         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.434          P=0.498          P=0.538         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.380N         P=0.580N         P=0.419N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 4

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain: Neuron                                                                                                                    |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             0.0%          |  0.0%             4.4%             7.2%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              692              ---           |  ---              611              610             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.725          P=0.490          (e)           |  P=0.066          P=0.229          P=0.100         |
|POLY 3             |        P=0.725          P=0.492          (e)           |  P=0.071          P=0.236          P=0.105         |
|POLY 1.5           |        P=0.727          P=0.494          (e)           |  P=0.075          P=0.237          P=0.109         |
|POLY 6             |        P=0.723          P=0.490          (e)           |  P=0.067          P=0.235          P=0.099         |
|LOGISTIC REGRESSION|        P=0.730N         P=0.502          (e)           |  P=0.116          P=0.220          P=0.145         |
|COCH-ARM / FISHERS |        P=0.731          P=0.500          (e)           |  P=0.082          P=0.247          P=0.121         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        2/50 (4%)     |                                                    |
|POLY-3 ADJUSTED (b)|        4.2%             2.2%             4.4%          |                                                    |
|TERMINAL (d)       |        1/41 (2%)        0/37 (0%)        2/36 (6%)     |                                                    |
|FIRST INCIDENCE    |        490              454              727 (T)       |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.579          P=0.519N         P=0.656       |                                                    |
|POLY 3             |        P=0.599          P=0.514N         P=0.678       |                                                    |
|POLY 1.5           |        P=0.603          P=0.510N         P=0.684       |                                                    |
|POLY 6             |        P=0.594          P=0.518N         P=0.672       |                                                    |
|LOGISTIC REGRESSION|        P=0.582N         P=0.329N         P=0.674N      |                                                    |
|COCH-ARM / FISHERS |        P=0.610          P=0.500N         P=0.691N      |                                                    |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 5

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Cornea                                                                                                                      |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/1 (0%)         2/2 (100%)       1/1 (100%)    |  1/1 (100%)       0/2 (0%)         1/1 (100%)      |
|POLY-3 ADJUSTED (b)|        0.0%             100.0%           100.0%        |  100.0%           0.0%             100.0%          |
|TERMINAL (d)       |        0/1 (0%)         2/2 (100%)       0/0 (0%)      |  0/0 (0%)         0/1 (0%)         1/1 (100%)      |
|FIRST INCIDENCE    |        ---              727 (T)          630           |  429              ---              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.103          P=0.362          P=0.480       |  P=0.512N         P=0.504N         (e)             |
|POLY 3             |        P=1.000N         P=1.000N         P=1.000N      |  P=0.949          P=0.223N         (e)             |
|POLY 1.5           |        P=1.000N         P=1.000N         P=1.000N      |  P=0.998          P=0.030N*        (e)             |
|POLY 6             |        P=1.000N         P=1.000N         P=1.000N      |  P=0.850          P=0.406N         (e)             |
|LOGISTIC REGRESSION|        (e)              P=0.362          (e)           |  P=0.681          (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.207          P=0.333          P=0.500       |  P=0.760          P=0.333N         (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             6.6%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/41 (0%)        1/37 (3%)        0/36 (0%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              356              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.622          P=0.116          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        P=0.627          P=0.116          (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.633          P=0.117          (e)           |  (e)              (e)              (e)             |
|POLY 6             |        P=0.621          P=0.115          (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.612N         P=0.180          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.640          P=0.121          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 6

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Duodenum                                                                                                        |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/49 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             0.0%             4.9%            |
|TERMINAL (d)       |        0/40 (0%)        0/37 (0%)        0/36 (0%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              ---              661             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.072          (e)              P=0.184         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.094          (e)              P=0.217         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.094          (e)              P=0.224         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.094          (e)              P=0.207         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.102          (e)              P=0.248         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.095          (e)              P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Jejunum                                                                                                         |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  1/49 (2%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.3%             0.0%             4.9%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  1/34 (3%)        0/36 (0%)        2/26 (8%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  729 (T)          ---              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.289          P=0.489N         P=0.406         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.361          P=0.499N         P=0.471         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.362          P=0.497N         P=0.484         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.359          P=0.503N         P=0.452         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.289          (e)              P=0.406         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.366          P=0.495N         P=0.508         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 7

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        21/50 (42%)      23/50 (46%)      21/50 (42%)   |  1/50 (2%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        43.4%            49.3%            46.0%         |  2.2%             0.0%             4.9%            |
|TERMINAL (d)       |        17/41 (42%)      17/37 (46%)      17/36 (47%)   |  1/35 (3%)        0/36 (0%)        1/26 (4%)       |
|FIRST INCIDENCE    |        490              507              667           |  729 (T)          ---              653             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.359          P=0.293          P=0.396       |  P=0.292          P=0.494N         P=0.408         |
|POLY 3             |        P=0.435          P=0.356          P=0.482       |  P=0.355          P=0.504N         P=0.465         |
|POLY 1.5           |        P=0.476          P=0.372          P=0.521       |  P=0.357          P=0.502N         P=0.478         |
|POLY 6             |        P=0.393          P=0.347          P=0.441       |  P=0.353          P=0.508N         P=0.448         |
|LOGISTIC REGRESSION|        P=0.515          P=0.410          P=0.549       |  P=0.336          (e)              P=0.467         |
|COCH-ARM / FISHERS |        P=0.540          P=0.420          P=0.580N      |  P=0.360          P=0.500N         P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Accumulation, Hyaline Droplet                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        0/50 (0%)     |  2/50 (4%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        2.1%             2.2%             0.0%          |  4.4%             0.0%             2.4%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        612              454              ---           |  664              ---              653             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.340N         P=0.753          P=0.513N      |  P=0.430N         P=0.253N         P=0.589N        |
|POLY 3             |        P=0.345N         P=0.753          P=0.507N      |  P=0.381N         P=0.243N         P=0.537N        |
|POLY 1.5           |        P=0.340N         P=0.755          P=0.504N      |  P=0.374N         P=0.240N         P=0.523N        |
|POLY 6             |        P=0.352N         P=0.750          P=0.511N      |  P=0.392N         P=0.248N         P=0.555N        |
|LOGISTIC REGRESSION|        P=0.272N         P=0.643N         P=0.466N      |  P=0.351N         P=0.237N         P=0.499N        |
|COCH-ARM / FISHERS |        P=0.331N         P=0.753N         P=0.500N      |  P=0.360N         P=0.247N         P=0.500N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 8

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        12/50 (24%)      16/50 (32%)      11/50 (22%)   |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        25.5%            35.6%            24.2%         |  0.0%             0.0%             2.5%            |
|TERMINAL (d)       |        9/41 (22%)       14/37 (38%)      9/36 (25%)    |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        612              645              662           |  ---              ---              722             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.499          P=0.175          P=0.565       |  P=0.233          (e)              P=0.450         |
|POLY 3             |        P=0.500N         P=0.205          P=0.537N      |  P=0.275          (e)              P=0.479         |
|POLY 1.5           |        P=0.482N         P=0.219          P=0.522N      |  P=0.273          (e)              P=0.487         |
|POLY 6             |        P=0.522N         P=0.191          P=0.554N      |  P=0.278          (e)              P=0.468         |
|LOGISTIC REGRESSION|        P=0.492N         P=0.208          P=0.529N      |  P=0.238          (e)              P=0.456         |
|COCH-ARM / FISHERS |        P=0.455N         P=0.252          P=0.500N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  4.4%             0.0%             0.0%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  679              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.129N         P=0.268N         P=0.311N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.105N         P=0.243N         P=0.264N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.101N         P=0.240N         P=0.254N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.111N         P=0.249N         P=0.279N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.089N         P=0.236N         P=0.232N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.095N         P=0.247N         P=0.247N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 9

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        47/50 (94%)      49/50 (98%)      50/50 (100%)  |  27/50 (54%)      24/50 (48%)      15/50 (30%)     |
|POLY-3 ADJUSTED (b)|        96.3%            99.9%            100.0%        |  58.6%            52.3%            34.6%           |
|TERMINAL (d)       |        40/41 (98%)      37/37 (100%)     36/36 (100%)  |  23/35 (66%)      21/36 (58%)      9/26 (35%)      |
|FIRST INCIDENCE    |        490              356              401           |  568              561              422             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.050          P=0.113          P=0.059       |  P=0.111N         P=0.304N         P=0.141N        |
|POLY 3             |        P=0.088          P=0.269          P=0.244       |  P=0.014N*        P=0.344N         P=0.016N*       |
|POLY 1.5           |        P=0.060          P=0.243          P=0.176       |  P=0.012N*        P=0.339N         P=0.014N*       |
|POLY 6             |        P=0.150          P=0.354          P=0.347       |  P=0.017N*        P=0.362N         P=0.020N*       |
|LOGISTIC REGRESSION|        P=0.022 *        P=0.095          P=0.074       |  P=0.024N*        P=0.399N         P=0.027N*       |
|COCH-ARM / FISHERS |        P=0.060          P=0.309          P=0.121       |  P=0.010N*        P=0.345N         P=0.013N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        3/50 (6%)     |  1/50 (2%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             6.7%          |  2.2%             0.0%             4.8%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        2/36 (6%)     |  1/35 (3%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              ---              713           |  729 (T)          ---              567             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.033 *        (e)              P=0.104       |  P=0.307          P=0.494N         P=0.429         |
|POLY 3             |        P=0.035 *        (e)              P=0.114       |  P=0.356          P=0.504N         P=0.467         |
|POLY 1.5           |        P=0.035 *        (e)              P=0.116       |  P=0.357          P=0.502N         P=0.479         |
|POLY 6             |        P=0.035 *        (e)              P=0.112       |  P=0.353          P=0.508N         P=0.451         |
|LOGISTIC REGRESSION|        P=0.035 *        (e)              P=0.111       |  P=0.374          (e)              P=0.510         |
|COCH-ARM / FISHERS |        P=0.037 *        (e)              P=0.121       |  P=0.360          P=0.500N         P=0.500         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 10

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Artery                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        4.3%             0.0%             2.2%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        2/41 (5%)        0/37 (0%)        1/36 (3%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        727 (T)          ---              727 (T)       |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.397N         P=0.261N         P=0.545N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.367N         P=0.247N         P=0.510N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.364N         P=0.244N         P=0.506N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.369N         P=0.249N         P=0.515N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.397N         (e)              P=0.545N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.360N         P=0.247N         P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.2%             0.0%             4.4%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/41 (2%)        0/37 (0%)        1/36 (3%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        727 (T)          ---              722           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.330          P=0.520N         P=0.458       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.358          P=0.509N         P=0.490       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.359          P=0.506N         P=0.494       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.357          P=0.511N         P=0.486       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.343          (e)              P=0.477       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.360          P=0.500N         P=0.500       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 11

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        0/50 (0%)     |  2/50 (4%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             6.6%             0.0%          |  4.4%             0.0%             0.0%            |
|TERMINAL (d)       |        0/41 (0%)        2/37 (5%)        0/36 (0%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              356              ---           |  702              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.615          P=0.110          (e)           |  P=0.123N         P=0.255N         P=0.304N        |
|POLY 3             |        P=0.627          P=0.115          (e)           |  P=0.104N         P=0.242N         P=0.263N        |
|POLY 1.5           |        P=0.633          P=0.116          (e)           |  P=0.101N         P=0.240N         P=0.253N        |
|POLY 6             |        P=0.621          P=0.113          (e)           |  P=0.110N         P=0.247N         P=0.277N        |
|LOGISTIC REGRESSION|        P=0.617N         P=0.164          (e)           |  P=0.103N         P=0.240N         P=0.260N        |
|COCH-ARM / FISHERS |        P=0.640          P=0.121          (e)           |  P=0.095N         P=0.247N         P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       8/50 (16%)       4/50 (8%)     |  2/50 (4%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        17.3%            18.0%            8.8%          |  4.4%             4.4%             4.8%            |
|TERMINAL (d)       |        8/41 (20%)       8/37 (22%)       3/36 (8%)     |  2/35 (6%)        1/36 (3%)        0/26 (0%)       |
|FIRST INCIDENCE    |        727 (T)          727 (T)          667           |  729 (T)          553              610             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.216N         P=0.520          P=0.242N      |  P=0.531          P=0.682N         P=0.623         |
|POLY 3             |        P=0.163N         P=0.571          P=0.188N      |  P=0.571          P=0.692          P=0.662         |
|POLY 1.5           |        P=0.159N         P=0.582          P=0.184N      |  P=0.581          P=0.693          P=0.673         |
|POLY 6             |        P=0.167N         P=0.562          P=0.192N      |  P=0.558          P=0.688          P=0.647         |
|LOGISTIC REGRESSION|        P=0.178N         P=0.520          P=0.200N      |  P=0.556N         P=0.693N         P=0.686N        |
|COCH-ARM / FISHERS |        P=0.152N         P=0.607N         P=0.178N      |  P=0.601          P=0.691N         P=0.691N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 12

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        20/50 (40%)      29/50 (58%)      31/50 (62%)   |  18/50 (36%)      25/50 (50%)      24/50 (48%)     |
|POLY-3 ADJUSTED (b)|        42.5%            63.1%            65.2%         |  38.8%            54.4%            54.0%           |
|TERMINAL (d)       |        18/41 (44%)      24/37 (65%)      25/36 (69%)   |  16/35 (46%)      21/36 (58%)      16/26 (62%)     |
|FIRST INCIDENCE    |        618              507              456           |  506              584              366             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.005 **       P=0.023 *        P=0.007 **    |  P=0.013 *        P=0.128          P=0.020 *       |
|POLY 3             |        P=0.014 *        P=0.034 *        P=0.019 *     |  P=0.082          P=0.093          P=0.103         |
|POLY 1.5           |        P=0.015 *        P=0.038 *        P=0.019 *     |  P=0.098          P=0.102          P=0.119         |
|POLY 6             |        P=0.014 *        P=0.032 *        P=0.019 *     |  P=0.061          P=0.082          P=0.079         |
|LOGISTIC REGRESSION|        P=0.012 *        P=0.032 *        P=0.018 *     |  P=0.082          P=0.094          P=0.120         |
|COCH-ARM / FISHERS |        P=0.018 *        P=0.055          P=0.022 *     |  P=0.134          P=0.113          P=0.156         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  4.4%             2.2%             0.0%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  701              644              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.182N         P=0.523N         P=0.300N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.166N         P=0.505N         P=0.262N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.157N         P=0.502N         P=0.253N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.179N         P=0.511N         P=0.277N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.140N         P=0.498N         P=0.264N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.142N         P=0.500N         P=0.247N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 13

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       7/50 (14%)       6/50 (12%)    |  1/50 (2%)        5/50 (10%)       0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        12.7%            15.8%            13.3%         |  2.2%             11.1%            0.0%            |
|TERMINAL (d)       |        5/41 (12%)       7/37 (19%)       6/36 (17%)    |  1/35 (3%)        4/36 (11%)       0/26 (0%)       |
|FIRST INCIDENCE    |        490              727 (T)          727 (T)       |  729 (T)          553              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.464          P=0.425          P=0.534       |  P=0.495N         P=0.112          P=0.559N        |
|POLY 3             |        P=0.526          P=0.456          P=0.590       |  P=0.480N         P=0.100          P=0.521N        |
|POLY 1.5           |        P=0.539          P=0.470          P=0.601       |  P=0.450N         P=0.101          P=0.514N        |
|POLY 6             |        P=0.511          P=0.442          P=0.577       |  P=0.524N         P=0.096          P=0.532N        |
|LOGISTIC REGRESSION|        P=0.536          P=0.476          P=0.611       |  P=0.423N         P=0.103          (e)             |
|COCH-ARM / FISHERS |        P=0.560          P=0.500          P=0.620N      |  P=0.399N         P=0.102          P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        2/50 (4%)     |  2/50 (4%)        5/50 (10%)       8/50 (16%)      |
|POLY-3 ADJUSTED (b)|        2.1%             6.6%             4.4%          |  4.3%             10.9%            18.6%           |
|TERMINAL (d)       |        0/41 (0%)        1/37 (3%)        1/36 (3%)     |  0/35 (0%)        1/36 (3%)        1/26 (4%)       |
|FIRST INCIDENCE    |        664              576              667           |  429              553              506             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.375          P=0.286          P=0.477       |  P=0.022 *        P=0.218          P=0.035 *       |
|POLY 3             |        P=0.387          P=0.295          P=0.490       |  P=0.023 *        P=0.208          P=0.033 *       |
|POLY 1.5           |        P=0.392          P=0.298          P=0.494       |  P=0.026 *        P=0.212          P=0.036 *       |
|POLY 6             |        P=0.381          P=0.294          P=0.485       |  P=0.021 *        P=0.205          P=0.029 *       |
|LOGISTIC REGRESSION|        P=0.415          P=0.355          P=0.509       |  P=0.082          P=0.160          P=0.097         |
|COCH-ARM / FISHERS |        P=0.399          P=0.309          P=0.500       |  P=0.033 *        P=0.218          P=0.046 *       |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 14

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        1/50 (2%)     |  0/50 (0%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        2.2%             0.0%             2.2%          |  0.0%             4.4%             2.5%            |
|TERMINAL (d)       |        1/41 (2%)        0/37 (0%)        1/36 (3%)     |  0/35 (0%)        1/36 (3%)        1/26 (4%)       |
|FIRST INCIDENCE    |        727 (T)          ---              727 (T)       |  ---              553              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.639          P=0.520N         P=0.733       |  P=0.305          P=0.247          P=0.441         |
|POLY 3             |        P=0.667          P=0.509N         P=0.754       |  P=0.326          P=0.236          P=0.479         |
|POLY 1.5           |        P=0.667          P=0.506N         P=0.757       |  P=0.339          P=0.237          P=0.486         |
|POLY 6             |        P=0.666          P=0.511N         P=0.751       |  P=0.309          P=0.233          P=0.468         |
|LOGISTIC REGRESSION|        P=0.639          (e)              P=0.733       |  P=0.379          P=0.226          P=0.441         |
|COCH-ARM / FISHERS |        P=0.669          P=0.500N         P=0.753N      |  P=0.360          P=0.247          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        4/50 (8%)        1/50 (2%)     |  1/50 (2%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        8.6%             9.0%             2.2%          |  2.2%             2.2%             4.9%            |
|TERMINAL (d)       |        3/41 (7%)        3/37 (8%)        1/36 (3%)     |  0/35 (0%)        1/36 (3%)        1/26 (4%)       |
|FIRST INCIDENCE    |        618              692              727 (T)       |  664              729 (T)          653             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.184N         P=0.593          P=0.217N      |  P=0.298          P=0.750          P=0.410         |
|POLY 3             |        P=0.160N         P=0.617          P=0.190N      |  P=0.357          P=0.755          P=0.463         |
|POLY 1.5           |        P=0.154N         P=0.625          P=0.186N      |  P=0.365          P=0.758          P=0.477         |
|POLY 6             |        P=0.167N         P=0.609          P=0.196N      |  P=0.347          P=0.750          P=0.445         |
|LOGISTIC REGRESSION|        P=0.154N         P=0.627          P=0.182N      |  P=0.366          P=0.762N         P=0.500         |
|COCH-ARM / FISHERS |        P=0.146N         P=0.643N         P=0.181N      |  P=0.378          P=0.753N         P=0.500         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 15

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/47 (0%)        1/45 (2%)        0/44 (0%)     |  0/49 (0%)        0/47 (0%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.5%             0.0%          |  0.0%             0.0%             5.0%            |
|TERMINAL (d)       |        0/40 (0%)        1/34 (3%)        0/32 (0%)     |  0/35 (0%)        0/35 (0%)        1/26 (4%)       |
|FIRST INCIDENCE    |        ---              727 (T)          ---           |  ---              ---              711             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.698          P=0.468          (e)           |  P=0.068          (e)              P=0.180         |
|POLY 3             |        P=0.716          P=0.481          (e)           |  P=0.095          (e)              P=0.212         |
|POLY 1.5           |        P=0.718          P=0.484          (e)           |  P=0.095          (e)              P=0.221         |
|POLY 6             |        P=0.713          P=0.478          (e)           |  P=0.095          (e)              P=0.201         |
|LOGISTIC REGRESSION|        (e)              P=0.468          (e)           |  P=0.074          (e)              P=0.190         |
|COCH-ARM / FISHERS |        P=0.721          P=0.489          (e)           |  P=0.097          (e)              P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/46 (2%)        1/48 (2%)        1/47 (2%)     |  0/48 (0%)        1/50 (2%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        2.4%             2.3%             2.3%          |  0.0%             2.2%             5.0%            |
|TERMINAL (d)       |        1/38 (3%)        1/37 (3%)        0/35 (0%)     |  0/33 (0%)        1/36 (3%)        1/26 (4%)       |
|FIRST INCIDENCE    |        727 (T)          727 (T)          722           |  ---              729 (T)          722             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.615          P=0.756          P=0.740       |  P=0.102          P=0.517          P=0.188         |
|POLY 3             |        P=0.637N         P=0.755N         P=0.758N      |  P=0.133          P=0.505          P=0.218         |
|POLY 1.5           |        P=0.635N         P=0.754N         P=0.757N      |  P=0.137          P=0.507          P=0.227         |
|POLY 6             |        P=0.639N         P=0.756N         P=0.760N      |  P=0.127          P=0.502          P=0.207         |
|LOGISTIC REGRESSION|        P=0.636          P=0.756          P=0.761       |  P=0.102          P=0.517          P=0.186         |
|COCH-ARM / FISHERS |        P=0.635N         P=0.742N         P=0.747N      |  P=0.144          P=0.510          P=0.253         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 16

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/46 (0%)        0/48 (0%)        2/47 (4%)     |  0/48 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.7%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/38 (0%)        0/37 (0%)        1/35 (3%)     |  0/33 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              ---              722           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.089          (e)              P=0.220       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.095          (e)              P=0.239       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.095          (e)              P=0.241       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.095          (e)              P=0.238       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.093          (e)              P=0.235       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.096          (e)              P=0.253       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/46 (4%)        2/48 (4%)        3/47 (6%)     |  1/48 (2%)        0/50 (0%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        4.7%             4.6%             7.0%          |  2.3%             0.0%             5.0%            |
|TERMINAL (d)       |        2/38 (5%)        1/37 (3%)        3/35 (9%)     |  0/33 (0%)        0/36 (0%)        1/26 (4%)       |
|FIRST INCIDENCE    |        727 (T)          696              727 (T)       |  681              ---              711             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.374          P=0.682          P=0.462       |  P=0.291          P=0.525N         P=0.407         |
|POLY 3             |        P=0.412          P=0.684N         P=0.505       |  P=0.360          P=0.496N         P=0.469         |
|POLY 1.5           |        P=0.413          P=0.683N         P=0.507       |  P=0.362          P=0.493N         P=0.483         |
|POLY 6             |        P=0.409          P=0.684N         P=0.502       |  P=0.358          P=0.500N         P=0.449         |
|LOGISTIC REGRESSION|        P=0.405          P=0.688N         P=0.462       |  P=0.335          P=0.492N         P=0.467         |
|COCH-ARM / FISHERS |        P=0.415          P=0.675N         P=0.510       |  P=0.365          P=0.490N         P=0.508         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 17

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/46 (2%)        0/48 (0%)        2/47 (4%)     |  1/48 (2%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             4.7%          |  2.3%             0.0%             0.0%            |
|TERMINAL (d)       |        1/38 (3%)        0/37 (0%)        1/35 (3%)     |  1/33 (3%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        727 (T)          ---              713           |  729 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.341          P=0.505N         P=0.472       |  P=0.293N         P=0.483N         P=0.548N        |
|POLY 3             |        P=0.365          P=0.495N         P=0.504       |  P=0.284N         P=0.495N         P=0.517N        |
|POLY 1.5           |        P=0.365          P=0.494N         P=0.506       |  P=0.278N         P=0.493N         P=0.509N        |
|POLY 6             |        P=0.365          P=0.496N         P=0.502       |  P=0.294N         P=0.498N         P=0.528N        |
|LOGISTIC REGRESSION|        P=0.359          (e)              P=0.499       |  P=0.293N         (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.365          P=0.489N         P=0.508       |  P=0.266N         P=0.490N         P=0.495N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/3 (0%)         0/3 (0%)         0/4 (0%)      |  2/12 (17%)       0/9 (0%)         0/8 (0%)        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  17.2%            0.0%             0.0%            |
|TERMINAL (d)       |        0/1 (0%)         0/2 (0%)         0/3 (0%)      |  2/8 (25%)        0/5 (0%)         0/6 (0%)        |
|FIRST INCIDENCE    |        ---              ---              ---           |  729 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.135N         P=0.341N         P=0.298N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.149N         P=0.349N         P=0.344N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.144N         P=0.327N         P=0.337N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.156N         P=0.377N         P=0.353N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.135N         (e)              (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.137N         P=0.314N         P=0.347N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 18

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/3 (33%)        1/3 (33%)        2/4 (50%)     |  9/12 (75%)       8/9 (89%)        7/8 (88%)       |
|POLY-3 ADJUSTED (b)|        42.1%            34.8%            50.0%         |  75.1%            96.7%            93.8%           |
|TERMINAL (d)       |        1/1 (100%)       1/2 (50%)        1/3 (33%)     |  6/8 (75%)        5/5 (100%)       6/6 (100%)      |
|FIRST INCIDENCE    |        727 (T)          727 (T)          595           |  687              616              661             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.648          P=0.638N         P=0.758       |  P=0.530          P=0.397          P=0.619         |
|POLY 3             |        P=0.564          P=0.730N         P=0.702       |  P=0.154          P=0.243          P=0.330         |
|POLY 1.5           |        P=0.521          P=0.745N         P=0.660       |  P=0.217          P=0.300          P=0.383         |
|POLY 6             |        P=0.634          P=0.700N         P=0.757N      |  P=0.099          P=0.202          P=0.269         |
|LOGISTIC REGRESSION|        P=0.470          P=0.638N         P=0.631       |  P=0.148          P=0.186          P=0.274         |
|COCH-ARM / FISHERS |        P=0.469          P=0.800N         P=0.629       |  P=0.313          P=0.414          P=0.465         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        2.2%             0.0%             2.2%          |  0.0%             2.2%             5.0%            |
|TERMINAL (d)       |        1/41 (2%)        0/37 (0%)        1/36 (3%)     |  0/35 (0%)        0/36 (0%)        0/25 (0%)       |
|FIRST INCIDENCE    |        727 (T)          ---              727 (T)       |  ---              678              621             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.639          P=0.520N         P=0.733       |  P=0.110          P=0.481          P=0.202         |
|POLY 3             |        P=0.667          P=0.509N         P=0.754       |  P=0.128          P=0.497          P=0.212         |
|POLY 1.5           |        P=0.667          P=0.506N         P=0.757       |  P=0.132          P=0.499          P=0.219         |
|POLY 6             |        P=0.666          P=0.511N         P=0.751       |  P=0.124          P=0.494          P=0.203         |
|LOGISTIC REGRESSION|        P=0.639          (e)              P=0.733       |  P=0.159          P=0.501          P=0.258         |
|COCH-ARM / FISHERS |        P=0.669          P=0.500N         P=0.753N      |  P=0.138          P=0.500          P=0.242         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 19

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                                                        |  0.0%             4.5%             0.0%            |
|TERMINAL (d)       |                                                        |  0/35 (0%)        2/36 (6%)        0/26 (0%)       |
|FIRST INCIDENCE    |                                                        |  ---              729 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.612          P=0.244          (e)             |
|POLY 3             |                                                        |  P=0.632          P=0.233          (e)             |
|POLY 1.5           |                                                        |  P=0.645          P=0.235          (e)             |
|POLY 6             |                                                        |  P=0.611          P=0.229          (e)             |
|LOGISTIC REGRESSION|                                                        |  (e)              P=0.244          (e)             |
|COCH-ARM / FISHERS |                                                        |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  15/50 (30%)      14/50 (28%)      15/50 (30%)     |
|POLY-3 ADJUSTED (b)|                                                        |  32.1%            30.8%            35.6%           |
|TERMINAL (d)       |                                                        |  11/35 (31%)      11/36 (31%)      9/26 (35%)      |
|FIRST INCIDENCE    |                                                        |  479              561              632             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.239          P=0.491N         P=0.265         |
|POLY 3             |                                                        |  P=0.419          P=0.536N         P=0.453         |
|POLY 1.5           |                                                        |  P=0.461          P=0.518N         P=0.499         |
|POLY 6             |                                                        |  P=0.368          P=0.563N         P=0.398         |
|LOGISTIC REGRESSION|                                                        |  P=0.431          P=0.510N         P=0.480         |
|COCH-ARM / FISHERS |                                                        |  P=0.544          P=0.500N         P=0.586N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 20

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  2/50 (4%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                                                        |  4.3%             0.0%             4.9%            |
|TERMINAL (d)       |                                                        |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |                                                        |  479              ---              672             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.551          P=0.253N         P=0.610         |
|POLY 3             |                                                        |  P=0.611          P=0.246N         P=0.650         |
|POLY 1.5           |                                                        |  P=0.615          P=0.242N         P=0.666         |
|POLY 6             |                                                        |  P=0.606          P=0.253N         P=0.628         |
|LOGISTIC REGRESSION|                                                        |  P=0.541N         P=0.275N         P=0.635N        |
|COCH-ARM / FISHERS |                                                        |  P=0.622          P=0.247N         P=0.691N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        5/50 (10%)    |  1/50 (2%)        4/50 (8%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        4.3%             4.5%             10.9%         |  2.2%             9.0%             2.4%            |
|TERMINAL (d)       |        1/41 (2%)        1/37 (3%)        3/36 (8%)     |  0/35 (0%)        4/36 (11%)       0/26 (0%)       |
|FIRST INCIDENCE    |        673              617              555           |  617              729 (T)          621             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.128          P=0.665          P=0.188       |  P=0.512          P=0.185          P=0.737         |
|POLY 3             |        P=0.143          P=0.680          P=0.212       |  P=0.543          P=0.170          P=0.737         |
|POLY 1.5           |        P=0.145          P=0.684          P=0.214       |  P=0.564          P=0.175          P=0.745         |
|POLY 6             |        P=0.142          P=0.677          P=0.210       |  P=0.513          P=0.163          P=0.724         |
|LOGISTIC REGRESSION|        P=0.152          P=0.687N         P=0.233       |  P=0.591          P=0.176          P=0.722N        |
|COCH-ARM / FISHERS |        P=0.146          P=0.691N         P=0.218       |  P=0.601          P=0.181          P=0.753N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 21

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hypertrophy Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)     |  3/50 (6%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.2%          |  6.5%             2.2%             2.5%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        1/36 (3%)     |  2/35 (6%)        1/36 (3%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              ---              727 (T)       |  568              729 (T)          728             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.254          (e)              P=0.474       |  P=0.264N         P=0.301N         P=0.394N        |
|POLY 3             |        P=0.271          (e)              P=0.494       |  P=0.232N         P=0.316N         P=0.349N        |
|POLY 1.5           |        P=0.271          (e)              P=0.496       |  P=0.221N         P=0.311N         P=0.332N        |
|POLY 6             |        P=0.271          (e)              P=0.492       |  P=0.249N         P=0.325N         P=0.372N        |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.474       |  P=0.211N         P=0.303N         P=0.311N        |
|COCH-ARM / FISHERS |        P=0.269          (e)              P=0.500       |  P=0.202N         P=0.309N         P=0.309N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Duct                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)     |  2/50 (4%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             2.2%          |  4.4%             2.2%             0.0%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        1/36 (3%)     |  2/35 (6%)        1/36 (3%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              617              727 (T)       |  729 (T)          729 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.315          P=0.496          P=0.474       |  P=0.183N         P=0.490N         P=0.306N        |
|POLY 3             |        P=0.327          P=0.493          P=0.494       |  P=0.165N         P=0.507N         P=0.262N        |
|POLY 1.5           |        P=0.329          P=0.495          P=0.496       |  P=0.157N         P=0.503N         P=0.253N        |
|POLY 6             |        P=0.325          P=0.492          P=0.492       |  P=0.178N         P=0.513N         P=0.275N        |
|LOGISTIC REGRESSION|        P=0.337          P=0.552          P=0.474       |  P=0.183N         P=0.490N         (e)             |
|COCH-ARM / FISHERS |        P=0.331          P=0.500          P=0.500       |  P=0.142N         P=0.500N         P=0.247N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 22

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/45 (4%)        3/47 (6%)        0/49 (0%)     |  0/48 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        4.8%             7.1%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        2/37 (5%)        2/34 (6%)        0/35 (0%)     |  0/34 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        727 (T)          454              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.217N         P=0.467          P=0.251N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.192N         P=0.504          P=0.226N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.187N         P=0.508          P=0.223N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.198N         P=0.498          P=0.229N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.169N         P=0.552          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.180N         P=0.521          P=0.226N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/45 (9%)        2/47 (4%)        4/49 (8%)     |  28/48 (58%)      31/50 (62%)      27/49 (55%)     |
|POLY-3 ADJUSTED (b)|        9.5%             4.8%             9.1%          |  63.6%            67.3%            63.2%           |
|TERMINAL (d)       |        3/37 (8%)        2/34 (6%)        3/35 (9%)     |  26/34 (77%)      27/36 (75%)      18/26 (69%)     |
|FIRST INCIDENCE    |        673              727 (T)          713           |  679              473              422             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.548          P=0.376N         P=0.610       |  P=0.124          P=0.437          P=0.151         |
|POLY 3             |        P=0.552N         P=0.344N         P=0.617N      |  P=0.535N         P=0.442          P=0.575N        |
|POLY 1.5           |        P=0.545N         P=0.335N         P=0.608N      |  P=0.498N         P=0.448          P=0.538N        |
|POLY 6             |        P=0.561N         P=0.354N         P=0.628N      |  P=0.511          P=0.414          P=0.564         |
|LOGISTIC REGRESSION|        P=0.563N         P=0.347N         P=0.624N      |  P=0.355          P=0.309          P=0.403         |
|COCH-ARM / FISHERS |        P=0.535N         P=0.318N         P=0.594N      |  P=0.412N         P=0.435          P=0.454N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 23

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        21/49 (43%)      21/50 (42%)      14/50 (28%)   |                                                    |
|POLY-3 ADJUSTED (b)|        46.1%            45.7%            30.8%         |                                                    |
|TERMINAL (d)       |        20/40 (50%)      16/37 (43%)      10/36 (28%)   |                                                    |
|FIRST INCIDENCE    |        673              507              662           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.174N         P=0.457          P=0.188N      |                                                    |
|POLY 3             |        P=0.082N         P=0.570N         P=0.096N      |                                                    |
|POLY 1.5           |        P=0.080N         P=0.570N         P=0.094N      |                                                    |
|POLY 6             |        P=0.084N         P=0.560N         P=0.098N      |                                                    |
|LOGISTIC REGRESSION|        P=0.092N         P=0.544          P=0.112N      |                                                    |
|COCH-ARM / FISHERS |        P=0.077N         P=0.547N         P=0.091N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Control                                                                                                                    |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             0.0%             7.3%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  0/35 (0%)        0/36 (0%)        1/26 (4%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              ---              621             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.025 *        (e)              P=0.088         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.034 *        (e)              P=0.102         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.035 *        (e)              P=0.108         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.034 *        (e)              P=0.095         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.035 *        (e)              P=0.114         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.037 *        (e)              P=0.121         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 24

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis, Skin, Site of Application                                                                                       |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       47/50 (94%)      50/50 (100%)  |  9/50 (18%)       47/50 (94%)      50/50 (100%)    |
|POLY-3 ADJUSTED (b)|        10.8%            95.8%            100.0%        |  19.7%            96.5%            100.0%          |
|TERMINAL (d)       |        5/41 (12%)       35/37 (95%)      36/36 (100%)  |  7/35 (20%)       35/36 (97%)      26/26 (100%)    |
|FIRST INCIDENCE    |        727 (T)          356              401           |  679              561              98              |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Sebaceous Gland, Skin, Site of Application                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        44/50 (88%)      49/50 (98%)   |  0/50 (0%)        42/50 (84%)      48/50 (96%)     |
|POLY-3 ADJUSTED (b)|        0.0%             92.8%            98.3%         |  0.0%             87.9%            97.5%           |
|TERMINAL (d)       |        0/41 (0%)        34/37 (92%)      36/36 (100%)  |  0/35 (0%)        33/36 (92%)      26/26 (100%)    |
|FIRST INCIDENCE    |        ---              507              401           |  ---              561              98              |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 25

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        24/50 (48%)      23/50 (46%)   |  5/50 (10%)       30/50 (60%)      40/50 (80%)     |
|POLY-3 ADJUSTED (b)|        0.0%             50.7%            48.9%         |  11.0%            63.4%            86.8%           |
|TERMINAL (d)       |        0/41 (0%)        16/37 (43%)      14/36 (39%)   |  4/35 (11%)       21/36 (58%)      23/26 (89%)     |
|FIRST INCIDENCE    |        ---              454              555           |  701              553              366             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        2/50 (4%)     |  3/50 (6%)        2/50 (4%)        11/50 (22%)     |
|POLY-3 ADJUSTED (b)|        4.3%             4.5%             4.4%          |  6.6%             4.5%             25.7%           |
|TERMINAL (d)       |        2/41 (5%)        2/37 (5%)        1/36 (3%)     |  2/35 (6%)        2/36 (6%)        6/26 (23%)      |
|FIRST INCIDENCE    |        727 (T)          727 (T)          630           |  701              729 (T)          366             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.555          P=0.658          P=0.656       |  P=0.002 **       P=0.499N         P=0.008 **      |
|POLY 3             |        P=0.593          P=0.678          P=0.686       |  P=0.005 **       P=0.510N         P=0.013 *       |
|POLY 1.5           |        P=0.595          P=0.683          P=0.689       |  P=0.005 **       P=0.504N         P=0.015 *       |
|POLY 6             |        P=0.590          P=0.674          P=0.684       |  P=0.004 **       P=0.519N         P=0.010 *       |
|LOGISTIC REGRESSION|        P=0.591          P=0.658          P=0.693       |  P=0.007 **       P=0.524N         P=0.022 *       |
|COCH-ARM / FISHERS |        P=0.601          P=0.691N         P=0.691N      |  P=0.008 **       P=0.500N         P=0.020 *       |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 26

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Parakeratosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        4/50 (8%)        5/50 (10%)    |  3/50 (6%)        4/50 (8%)        16/50 (32%)     |
|POLY-3 ADJUSTED (b)|        2.2%             8.9%             10.9%         |  6.6%             8.9%             36.9%           |
|TERMINAL (d)       |        1/41 (2%)        2/37 (5%)        2/36 (6%)     |  1/35 (3%)        3/36 (8%)        7/26 (27%)      |
|FIRST INCIDENCE    |        727 (T)          645              555           |  679              644              564             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.069          P=0.160          P=0.089       |  P<0.001 **       P=0.486          P<0.001 **      |
|POLY 3             |        P=0.078          P=0.169          P=0.100       |  P<0.001 **       P=0.490          P<0.001 **      |
|POLY 1.5           |        P=0.079          P=0.171          P=0.101       |  P<0.001 **       P=0.496          P<0.001 **      |
|POLY 6             |        P=0.078          P=0.167          P=0.100       |  P<0.001 **       P=0.479          P<0.001 **      |
|LOGISTIC REGRESSION|        P=0.082          P=0.173          P=0.112       |  P<0.001 **       P=0.495          P<0.001 **      |
|COCH-ARM / FISHERS |        P=0.080          P=0.181          P=0.102       |  P<0.001 **       P=0.500          P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        7/50 (14%)    |  1/50 (2%)        0/50 (0%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        2.2%             0.0%             15.3%         |  2.2%             0.0%             7.3%            |
|TERMINAL (d)       |        1/41 (2%)        0/37 (0%)        4/36 (11%)    |  1/35 (3%)        0/36 (0%)        1/26 (4%)       |
|FIRST INCIDENCE    |        727 (T)          ---              630           |  729 (T)          ---              711             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.006 **       P=0.520N         P=0.026 *     |  P=0.121          P=0.494N         P=0.215         |
|POLY 3             |        P=0.006 **       P=0.509N         P=0.028 *     |  P=0.169          P=0.504N         P=0.269         |
|POLY 1.5           |        P=0.006 **       P=0.506N         P=0.029 *     |  P=0.171          P=0.502N         P=0.282         |
|POLY 6             |        P=0.005 **       P=0.511N         P=0.028 *     |  P=0.167          P=0.508N         P=0.251         |
|LOGISTIC REGRESSION|        P=0.007 **       (e)              P=0.031 *     |  P=0.129          (e)              P=0.226         |
|COCH-ARM / FISHERS |        P=0.007 **       P=0.500N         P=0.030 *     |  P=0.176          P=0.500N         P=0.309         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 27

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        25/50 (50%)      23/50 (46%)      30/50 (60%)   |  33/50 (66%)      33/50 (66%)      36/50 (72%)     |
|POLY-3 ADJUSTED (b)|        50.7%            47.8%            61.5%         |  67.0%            69.3%            76.1%           |
|TERMINAL (d)       |        18/41 (44%)      14/37 (38%)      19/36 (53%)   |  20/35 (57%)      25/36 (69%)      19/26 (73%)     |
|FIRST INCIDENCE    |        420              356              401           |  429              553              98              |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.124          P=0.565          P=0.135       |  P=0.044 *        P=0.557N         P=0.058         |
|POLY 3             |        P=0.165          P=0.468N         P=0.190       |  P=0.187          P=0.490          P=0.216         |
|POLY 1.5           |        P=0.173          P=0.457N         P=0.198       |  P=0.235          P=0.532          P=0.268         |
|POLY 6             |        P=0.158          P=0.472N         P=0.180       |  P=0.126          P=0.429          P=0.149         |
|LOGISTIC REGRESSION|        P=0.209          P=0.355N         P=0.247       |  P=0.329          P=0.580N         P=0.401         |
|COCH-ARM / FISHERS |        P=0.184          P=0.421N         P=0.211       |  P=0.296          P=0.583N         P=0.333         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  1/50 (2%)        5/50 (10%)       0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.2%             11.2%            0.0%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  1/35 (3%)        5/36 (14%)       0/26 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  729 (T)          729 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.512N         P=0.108          P=0.559N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.480N         P=0.097          P=0.521N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.450N         P=0.100          P=0.514N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.524N         P=0.092          P=0.532N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.512N         P=0.108          (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.399N         P=0.102          P=0.500N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 28

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        0/50 (0%)     |  2/50 (4%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        2.1%             2.3%             0.0%          |  4.4%             4.5%             2.5%            |
|TERMINAL (d)       |        0/41 (0%)        1/37 (3%)        0/36 (0%)     |  1/35 (3%)        1/36 (3%)        1/26 (4%)       |
|FIRST INCIDENCE    |        420              727 (T)          ---           |  713              616              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.349N         P=0.744          P=0.504N      |  P=0.481N         P=0.690          P=0.603N        |
|POLY 3             |        P=0.348N         P=0.747          P=0.509N      |  P=0.439N         P=0.690          P=0.538N        |
|POLY 1.5           |        P=0.342N         P=0.751          P=0.506N      |  P=0.421N         P=0.692          P=0.524N        |
|POLY 6             |        P=0.354N         P=0.744          P=0.513N      |  P=0.464N         P=0.685          P=0.557N        |
|LOGISTIC REGRESSION|        P=0.288N         P=0.680N         P=0.363N      |  P=0.419N         P=0.695N         P=0.583N        |
|COCH-ARM / FISHERS |        P=0.331N         P=0.753N         P=0.500N      |  P=0.390N         P=0.691N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)     |  1/50 (2%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        2.1%             0.0%             0.0%          |  2.2%             0.0%             4.9%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  0/35 (0%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        490              ---              ---           |  719              ---              661             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.274N         P=0.508N         P=0.504N      |  P=0.293          P=0.505N         P=0.410         |
|POLY 3             |        P=0.278N         P=0.512N         P=0.509N      |  P=0.355          P=0.504N         P=0.465         |
|POLY 1.5           |        P=0.275N         P=0.508N         P=0.505N      |  P=0.357          P=0.502N         P=0.477         |
|POLY 6             |        P=0.281N         P=0.515N         P=0.512N      |  P=0.353          P=0.508N         P=0.448         |
|LOGISTIC REGRESSION|        P=0.204N         P=0.325N         P=0.415N      |  P=0.340          P=0.508N         P=0.473         |
|COCH-ARM / FISHERS |        P=0.269N         P=0.500N         P=0.500N      |  P=0.360          P=0.500N         P=0.500         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 29

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  4.4%             0.0%             0.0%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  2/35 (6%)        0/36 (0%)        0/26 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  729 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.118N         P=0.232N         P=0.306N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.104N         P=0.241N         P=0.262N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.100N         P=0.239N         P=0.253N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.109N         P=0.245N         P=0.275N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.118N         (e)              (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.095N         P=0.247N         P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  4.4%             2.2%             2.5%            |
|TERMINAL (d)       |        0/41 (0%)        0/37 (0%)        0/36 (0%)     |  1/35 (3%)        0/36 (0%)        1/26 (4%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  679              678              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.475N         P=0.522N         P=0.606N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.416N         P=0.507N         P=0.539N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.402N         P=0.503N         P=0.524N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.435N         P=0.513N         P=0.559N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.404N         P=0.499N         P=0.550N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.378N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 30

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        1/50 (2%)     |                                                    |
|POLY-3 ADJUSTED (b)|        4.2%             4.4%             2.2%          |                                                    |
|TERMINAL (d)       |        1/41 (2%)        1/37 (3%)        1/36 (3%)     |                                                    |
|FIRST INCIDENCE    |        490              356              727 (T)       |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.421N         P=0.668          P=0.532N      |                                                    |
|POLY 3             |        P=0.411N         P=0.680          P=0.515N      |                                                    |
|POLY 1.5           |        P=0.403N         P=0.685          P=0.509N      |                                                    |
|POLY 6             |        P=0.419N         P=0.675          P=0.522N      |                                                    |
|LOGISTIC REGRESSION|        P=0.343N         P=0.554N         P=0.465N      |                                                    |
|COCH-ARM / FISHERS |        P=0.390N         P=0.691N         P=0.500N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        13/43 (30%)      13/44 (30%)      14/41 (34%)   |  7/47 (15%)       4/40 (10%)       8/41 (20%)      |
|POLY-3 ADJUSTED (b)|        31.2%            31.2%            35.3%         |  16.2%            10.7%            22.8%           |
|TERMINAL (d)       |        9/36 (25%)       7/33 (21%)       7/31 (23%)    |  1/33 (3%)        1/30 (3%)        1/24 (4%)       |
|FIRST INCIDENCE    |        584              356              456           |  664              553              610             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.349          P=0.505          P=0.382       |  P=0.288          P=0.313N         P=0.305         |
|POLY 3             |        P=0.394          P=0.589N         P=0.440       |  P=0.301          P=0.350N         P=0.328         |
|POLY 1.5           |        P=0.395          P=0.584N         P=0.440       |  P=0.311          P=0.353N         P=0.344         |
|POLY 6             |        P=0.395          P=0.591N         P=0.441       |  P=0.289          P=0.352N         P=0.311         |
|LOGISTIC REGRESSION|        P=0.427          P=0.465N         P=0.478       |  P=0.387          P=0.362N         P=0.377         |
|COCH-ARM / FISHERS |        P=0.396          P=0.565N         P=0.440       |  P=0.338          P=0.362N         P=0.385         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 31

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/43 (0%)        0/44 (0%)        0/41 (0%)     |  1/47 (2%)        2/40 (5%)        1/41 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.4%             5.6%             3.0%            |
|TERMINAL (d)       |        0/36 (0%)        0/33 (0%)        0/31 (0%)     |  1/33 (3%)        2/30 (7%)        1/24 (4%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  729 (T)          729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.522          P=0.467          P=0.689         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.542          P=0.442          P=0.707         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.553          P=0.443          P=0.715         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.528          P=0.439          P=0.698         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.522          P=0.467          P=0.689         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.576          P=0.439          P=0.718         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      20/50 (40%)      23/50 (46%)   |  27/50 (54%)      36/50 (72%)      33/50 (66%)     |
|POLY-3 ADJUSTED (b)|        23.6%            44.7%            50.3%         |  58.1%            77.4%            77.6%           |
|TERMINAL (d)       |        10/41 (24%)      18/37 (49%)      20/36 (56%)   |  24/35 (69%)      30/36 (83%)      24/26 (92%)     |
|FIRST INCIDENCE    |        673              652              555           |  506              567              621             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.002 **       P=0.019 *        P=0.003 **    |  P<0.001 **       P=0.057          P=0.002 **      |
|POLY 3             |        P=0.004 **       P=0.026 *        P=0.006 **    |  P=0.019 *        P=0.031 *        P=0.032 *       |
|POLY 1.5           |        P=0.005 **       P=0.030 *        P=0.007 **    |  P=0.041 *        P=0.038 *        P=0.061         |
|POLY 6             |        P=0.003 **       P=0.023 *        P=0.005 **    |  P=0.006 **       P=0.025 *        P=0.013 *       |
|LOGISTIC REGRESSION|        P=0.004 **       P=0.023 *        P=0.006 **    |  P=0.010 *        P=0.028 *        P=0.014 *       |
|COCH-ARM / FISHERS |        P=0.008 **       P=0.041 *        P=0.010 *     |  P=0.126          P=0.048 *        P=0.154         |
|=================================================================================================================================|
       Date:  09/26/97                           EXPERIMENT: 55312 TEST: 04                                            Page 32

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 103 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          100              200           |  0 MG/KG          100              200             |
|                   |                         MG/KG            MG/KG         |                   MG/KG            MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  37/50 (74%)      26/50 (52%)      22/50 (44%)     |
|POLY-3 ADJUSTED (b)|                                                        |  77.1%            55.3%            47.9%           |
|TERMINAL (d)       |                                                        |  29/35 (83%)      19/36 (53%)      10/26 (39%)     |
|FIRST INCIDENCE    |                                                        |  429              561              366             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.085N         P=0.032N*        P=0.123N        |
|POLY 3             |                                                        |  P=0.002N**       P=0.016N*        P=0.002N**      |
|POLY 1.5           |                                                        |  P=0.002N**       P=0.017N*        P=0.002N**      |
|POLY 6             |                                                        |  P=0.002N**       P=0.017N*        P=0.002N**      |
|LOGISTIC REGRESSION|                                                        |  P=0.002N**       P=0.020N*        P=0.002N**      |
|COCH-ARM / FISHERS |                                                        |  P=0.002N**       P=0.019N*        P=0.002N**      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).