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TDMS Study 55323-03 Pathology Tables

NTP  EXP/TEST: 55323-03                      LAURIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 1
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 07/17/97
ROUTE: SKIN APPLICATION                                                                                           TIME: 13:33:40

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  55323B

       CONTRACT NUMBER:  NO1-ES-15314

       CAS NUMBER:  120-40-1

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 55323-03                      LAURIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 2
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 07/17/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:33:40
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 SPECIES-STRAIN: RATS-F 344                          TRT#: 2                      ROOM/AREA:    202         FIRST DOSE: 12/15/92
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

159         159  225 07/27/93   673 10/18/94  15/26  Irritation Site of Applic

170         170  673 10/18/94   701 11/15/94   2/26  Irritation Site of Applic

175         175  393 01/11/94   393 01/11/94   1/26  Irritation Site of Applic

180         180  337 11/16/93   701 11/15/94  14/26  Irritation Site of Applic

185         185  309 10/19/93   673 10/18/94  14/25  Irritation Site of Applic

196         196  309 10/19/93   701 11/15/94  15/26  Irritation Site of Applic

199         199  309 10/19/93   449 03/08/94   6/17  Irritation Site of Applic

NTP  EXP/TEST: 55323-03                      LAURIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 3
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 07/17/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:33:40
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:    202         FIRST DOSE: 12/15/92
            SEX: FEMALE                               TRT: 50 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

242         242  393 01/11/94   393 01/11/94   1/23  Irritation Site of Applic

NTP  EXP/TEST: 55323-03                      LAURIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 4
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 07/17/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:33:40
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:    202         FIRST DOSE: 12/15/92
            SEX: FEMALE                               TRT: 100     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

255         255  477 04/05/94   477 04/05/94   1/26  Irritation Site of Applic

257         257  701 11/15/94   701 11/15/94   1/26  Irritation Site of Applic

268         268  365 12/14/93   505 05/03/94   6/19  Irritation Site of Applic

283         283  505 05/03/94   505 05/03/94   1/19  Irritation Site of Applic

291         291  701 11/15/94   701 11/15/94   1/26  Irritation Site of Applic

NTP  EXP/TEST: 55323-03                      LAURIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 5
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 07/17/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:33:40
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 1                      ROOM/AREA:    202         FIRST DOSE: 12/14/92
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 55323-03                      LAURIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 6
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 07/17/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:33:40
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 3                      ROOM/AREA:    202         FIRST DOSE: 12/14/92
            SEX: MALE                                 TRT: 50 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

95           95  449 03/07/94   449 03/07/94   1/24  Irritation Site of Applic

NTP  EXP/TEST: 55323-03                      LAURIC ACID DIETHANOLAMINE CONDENSATE                                PAGE: 7
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 07/17/97
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 13:33:40
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:    202         FIRST DOSE: 12/14/92
            SEX: MALE                                 TRT: 100     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

106         106  673 10/17/94   701 11/14/94   2/26  Irritation Site of Applic



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