TDMS Study 55323-03 Pathology Tables
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 CORE STUDY Facility: Battelle Columbus Laboratory Chemical CAS #: 120-40-1 Lock Date: 07/13/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Natural Death 11 12 22 Moribund Sacrifice 10 12 5 Accidently Killed 1 1 Survivors Terminal Sacrifice 28 26 22 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (45) (46) (43) Parasite Metazoan 2 (4%) 4 (9%) 3 (7%) Intestine Large, Rectum (42) (45) (43) Inflammation, Chronic Active 1 (2%) Parasite Metazoan 2 (5%) 2 (4%) 1 (2%) Intestine Large, Cecum (40) (40) (31) Inflammation, Chronic Active 1 (3%) Intestine Small, Duodenum (49) (49) (49) Inflammation, Chronic Active 1 (2%) Ulcer 1 (2%) Intestine Small, Jejunum (42) (43) (38) Mineralization 1 (2%) Intestine Small, Ileum (48) (42) (37) Parasite Metazoan 1 (3%) Liver (50) (50) (50) Basophilic Focus 1 (2%) 1 (2%) Clear Cell Focus 1 (2%) 3 (6%) 2 (4%) Eosinophilic Focus 3 (6%) 2 (4%) Hepatodiaphragmatic Nodule 12 (24%) 17 (34%) 12 (24%) Inflammation, Chronic Active 13 (26%) 15 (30%) 4 (8%) Mixed Cell Focus 1 (2%) Necrosis 4 (8%) Vacuolization Cytoplasmic 3 (6%) 6 (12%) 2 (4%) Bile Duct, Hyperplasia 1 (2%) Central Vein, Dilatation 1 (2%) Hepatocyte, Hyperplasia 1 (2%) 1 (2%) 1 (2%) Mesentery (5) (2) (4) Necrosis 1 (50%) Fat, Inflammation, Chronic Active 4 (80%) 1 (50%) 3 (75%) Fat, Mineralization 2 (50%) Oral Mucosa (1) (1) Hyperplasia 1 (100%) Pancreas (50) (50) (49) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Inflammation, Chronic Active 1 (2%) Necrosis 1 (2%) Acinus, Atrophy 3 (6%) 5 (10%) 1 (2%) Arteriole, Thrombosis 1 (2%) Stomach, Forestomach (50) (50) (50) Hemorrhage 1 (2%) Inflammation, Chronic Active 2 (4%) 2 (4%) Ulcer 2 (4%) 2 (4%) 1 (2%) Stomach, Glandular (50) (50) (49) Erosion 3 (6%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (50) (50) Inflammation, Chronic Active 1 (2%) Heart (50) (50) (49) Hemorrhage 1 (2%) Mineralization 1 (2%) Myocardium, Inflammation, Chronic Active 27 (54%) 31 (62%) 35 (71%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) Accessory Adrenal Cortical Nodule 2 (4%) 2 (4%) 3 (6%) Angiectasis 2 (4%) Degeneration 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hemorrhage 2 (4%) 2 (4%) 1 (2%) Hyperplasia 1 (2%) 2 (4%) 1 (2%) Hypertrophy 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) 1 (2%) Vacuolization Cytoplasmic 5 (10%) 4 (8%) 7 (14%) Adrenal Medulla (50) (50) (50) Hyperplasia 1 (2%) Parathyroid Gland (47) (40) (45) Hyperplasia 1 (2%) 2 (4%) Pituitary Gland (50) (50) (49) Cyst 8 (16%) 5 (10%) 3 (6%) Hemorrhage 1 (2%) Hyperplasia 4 (8%) 2 (4%) Thrombosis 1 (2%) Pars Distalis, Angiectasis 1 (2%) 2 (4%) Pars Distalis, Hyperplasia 1 (2%) 2 (4%) Thyroid Gland (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT C-Cell, Hyperplasia 2 (4%) 5 (10%) 3 (6%) Follicle, Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (49) (48) (48) Cyst 4 (8%) 1 (2%) Inflammation, Chronic Active 30 (61%) 34 (71%) 36 (75%) Mineralization 1 (2%) Necrosis 1 (2%) Ovary (50) (50) (50) Follicle, Cyst 3 (6%) 1 (2%) 1 (2%) Periovarian Tissue, Cyst 5 (10%) 8 (16%) 5 (10%) Uterus (50) (50) (50) Congestion 1 (2%) Cyst 1 (2%) Hemorrhage 1 (2%) Hydrometra 4 (8%) 4 (8%) 8 (16%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) Inflammation, Chronic Active 2 (4%) Myelofibrosis 1 (2%) Lymph Node (3) (3) (1) Hemorrhage 1 (33%) Pigmentation, Hemosiderin 1 (33%) Lymph Node, Mandibular (49) (50) (49) Atrophy 1 (2%) Hemorrhage 1 (2%) Lymph Node, Mesenteric (50) (50) (50) Ectasia 1 (2%) 1 (2%) Hemorrhage 1 (2%) 1 (2%) Pigmentation, Lipofuscin 2 (4%) 4 (8%) Arteriole, Inflammation, Chronic Active 1 (2%) Spleen (50) (50) (50) Angiectasis 1 (2%) Congestion 1 (2%) 1 (2%) 1 (2%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Necrosis 1 (2%) 1 (2%) Pigmentation, Hemosiderin 1 (2%) Thrombosis 3 (6%) Thymus (44) (49) (48) Atrophy 2 (5%) 1 (2%) Hemorrhage 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) Dilatation 35 (70%) 40 (80%) 32 (64%) Fibrosis 1 (2%) Galactocele 1 (2%) Hyperplasia, Cystic, Focal 1 (2%) Hyperplasia, Focal 2 (4%) 3 (6%) 2 (4%) Skin (50) (50) (50) Parakeratosis 1 (2%) 1 (2%) Epidermis, Skin, Site of Application, Hyperplasia 5 (10%) 33 (66%) 44 (88%) Sebaceous Gland, Skin, Site of Application, Hyperplasia 3 (6%) 41 (82%) 45 (90%) Skin, Site of Application, Hyperkeratosis 20 (40%) 29 (58%) Skin, Site of Application, Inflammation, Chronic Active 3 (6%) 35 (70%) 34 (68%) Skin, Site of Application, Parakeratosis 2 (4%) 12 (24%) 25 (50%) Skin, Site of Application, Ulcer 3 (6%) 2 (4%) 10 (20%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) Hemorrhage 2 (4%) Inflammation, Chronic Active 1 (2%) Spinal Cord (1) (1) Hemorrhage 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) Congestion 1 (2%) 3 (6%) Hemorrhage 2 (4%) Inflammation, Chronic Active 2 (4%) 2 (4%) 8 (16%) Mineralization 23 (46%) 18 (36%) 19 (38%) Interstitium, Fibrosis 2 (4%) 2 (4%) Nose (50) (50) (50) Inflammation, Suppurative 4 (8%) 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (1) (6) Cataract 1 (17%) Synechia 1 (100%) Lens, Mineralization 1 (100%) 3 (50%) Posterior Chamber, Hemorrhage 1 (17%) Retina, Degeneration 1 (100%) 1 (17%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) Cyst 2 (4%) 2 (4%) Inflammation, Chronic Active 2 (4%) Mineralization 24 (48%) 23 (46%) 27 (54%) Necrosis 1 (2%) Nephropathy 40 (80%) 41 (82%) 40 (80%) Pigmentation, Hemosiderin 2 (4%) 2 (4%) 2 (4%) Renal Tubule, Regeneration 2 (4%) 4 (8%) 2 (4%) Urinary Bladder (49) (49) (47) Inflammation, Chronic Active 3 (6%) Mineralization 1 (2%) Pigmentation, Hemosiderin 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Moribund Sacrifice 31 29 25 Natural Death 7 3 8 Accidently Killed 1 Survivors Terminal Sacrifice 12 18 16 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (49) (50) (46) Cyst 1 (2%) Parasite Metazoan 4 (8%) Intestine Large, Rectum (48) (49) (47) Parasite Metazoan 2 (4%) 2 (4%) 5 (11%) Intestine Large, Cecum (41) (47) (44) Ulcer 1 (2%) Intestine Small, Duodenum (50) (50) (50) Ulcer 1 (2%) Intestine Small, Jejunum (45) (50) (46) Inflammation, Chronic 1 (2%) Liver (50) (50) (50) Eosinophilic Focus 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hepatodiaphragmatic Nodule 5 (10%) 8 (16%) 6 (12%) Hypertrophy 1 (2%) Inflammation, Chronic Active 6 (12%) 4 (8%) 3 (6%) Necrosis 2 (4%) 2 (4%) Vacuolization Cytoplasmic 11 (22%) 14 (28%) 15 (30%) Bile Duct, Hyperplasia 7 (14%) 6 (12%) 6 (12%) Periportal, Fibrosis 1 (2%) Mesentery (12) (8) (6) Arteriole, Inflammation, Chronic Active 1 (13%) Fat, Inflammation, Chronic Active 12 (100%) 6 (75%) 2 (33%) Fat, Mineralization 6 (50%) 4 (50%) 1 (17%) Fat, Necrosis 1 (17%) Pancreas (50) (50) (50) Cyst 1 (2%) Inflammation, Chronic Active 1 (2%) Acinus, Atrophy 5 (10%) 5 (10%) 11 (22%) Arteriole, Inflammation, Chronic Active 1 (2%) Salivary Glands (50) (50) (50) Atrophy 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Stomach, Forestomach (50) (50) (50) Edema 2 (4%) Fibrosis 1 (2%) Hyperkeratosis 1 (2%) 2 (4%) 1 (2%) Hyperplasia 1 (2%) 2 (4%) Inflammation, Chronic Active 10 (20%) 6 (12%) 7 (14%) Mineralization 1 (2%) Ulcer 11 (22%) 5 (10%) 3 (6%) Stomach, Glandular (50) (50) (50) Erosion 1 (2%) Mineralization 1 (2%) 3 (6%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (50) (50) Mineralization 2 (4%) Heart (50) (50) (50) Mineralization 2 (4%) 2 (4%) Thrombosis 1 (2%) 1 (2%) Myocardium, Inflammation, Chronic Active 36 (72%) 39 (78%) 41 (82%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) Accessory Adrenal Cortical Nodule 1 (2%) 7 (14%) 6 (12%) Degeneration 1 (2%) 1 (2%) Hyperplasia 3 (6%) Mineralization 1 (2%) Pigmentation, Lipofuscin 1 (2%) Thrombosis 1 (2%) Vacuolization Cytoplasmic 19 (38%) 21 (42%) 22 (44%) Adrenal Medulla (50) (50) (50) Hyperplasia 4 (8%) 2 (4%) 1 (2%) Mineralization 1 (2%) Parathyroid Gland (47) (45) (47) Hyperplasia 16 (34%) 17 (38%) 13 (28%) Pituitary Gland (50) (50) (50) Cyst 1 (2%) Hyperplasia 1 (2%) 1 (2%) Mineralization 1 (2%) Thyroid Gland (50) (50) (50) Ultimobranchial Cyst 1 (2%) C-Cell, Hyperplasia 3 (6%) 3 (6%) Follicle, Cyst 4 (8%) 2 (4%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Penis (1) Congestion 1 (100%) Preputial Gland (50) (50) (50) Cyst 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic Active 50 (100%) 46 (92%) 43 (86%) Inflammation, Suppurative 1 (2%) 1 (2%) Prostate (50) (50) (49) Cyst 1 (2%) 1 (2%) Fibrosis 1 (2%) Inflammation, Chronic Active 7 (14%) 5 (10%) 3 (6%) Seminal Vesicle (50) (50) (49) Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%) Testes (50) (50) (50) Degeneration 15 (30%) 16 (32%) 17 (34%) Inflammation, Chronic Active 2 (4%) 4 (8%) 5 (10%) Mineralization 4 (8%) 6 (12%) 7 (14%) Necrosis 1 (2%) Interstitial Cell, Hyperplasia 3 (6%) 2 (4%) 4 (8%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) Myelofibrosis 1 (2%) Necrosis 1 (2%) Lymph Node (2) (4) Angiectasis 1 (50%) Congestion 1 (25%) Lymph Node, Mandibular (50) (50) (50) Hyperplasia 1 (2%) Lymph Node, Mesenteric (50) (50) (50) Amyloid Deposition 1 (2%) Atrophy 2 (4%) 1 (2%) Congestion 1 (2%) Ectasia 1 (2%) 2 (4%) 1 (2%) Necrosis 1 (2%) Spleen (50) (50) (50) Congestion 8 (16%) 5 (10%) 5 (10%) Fibrosis 3 (6%) 3 (6%) 3 (6%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hemorrhage 1 (2%) Pigmentation, Hemosiderin 1 (2%) Lymphoid Follicle, Depletion Cellular 1 (2%) Red Pulp, Hyperplasia 1 (2%) Thymus (44) (50) (47) Atrophy 7 (16%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (49) Dilatation 28 (56%) 34 (68%) 31 (63%) Galactocele 6 (12%) 7 (14%) 9 (18%) Hyperplasia 8 (16%) 9 (18%) 5 (10%) Hyperplasia, Cystic, Focal 1 (2%) Hyperplasia, Focal 5 (10%) 8 (16%) 5 (10%) Pigmentation, Hemosiderin 1 (2%) Skin (50) (50) (50) Hemorrhage 1 (2%) Hyperkeratosis 1 (2%) Parakeratosis 1 (2%) Epidermis, Pinna, Hyperplasia 1 (2%) Epidermis, Skin, Site of Application, Hyperplasia 29 (58%) 44 (88%) Pinna, Parakeratosis 1 (2%) Sebaceous Gland, Skin, Site of Application, Hyperplasia 27 (54%) 44 (88%) Skin, Site of Application, Edema 1 (2%) Skin, Site of Application, Hyperkeratosis 23 (46%) 25 (50%) Skin, Site of Application, Inflammation, Chronic Active 10 (20%) 28 (56%) Skin, Site of Application, Parakeratosis 21 (42%) 33 (66%) Skin, Site of Application, Ulcer 4 (8%) 25 (50%) Subcutaneous Tissue, Fibrosis 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) Fibrous Osteodystrophy 1 (2%) 1 (2%) Osteosclerosis 1 (2%) Skeletal Muscle (1) Hemorrhage 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97 Route: SKIN APPLICATION Time: 12:22:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) Hydrocephalus 1 (2%) 1 (2%) Mineralization 1 (2%) Vacuolization Cytoplasmic 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) Cyst 1 (2%) Hemorrhage 1 (2%) Inflammation, Chronic Active 1 (2%) 3 (6%) 4 (8%) Mineralization 21 (42%) 22 (44%) 34 (68%) Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) Interstitium, Fibrosis 2 (4%) Nose (50) (50) (50) Inflammation, Chronic Active 1 (2%) Inflammation, Suppurative 11 (22%) 5 (10%) 3 (6%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (2) Mineralization 1 (50%) Lens, Mineralization 1 (100%) 1 (50%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) Cyst 7 (14%) 4 (8%) 6 (12%) Fibrosis 1 (2%) Inflammation, Chronic Active 1 (2%) Mineralization 1 (2%) 1 (2%) 3 (6%) Nephropathy 42 (84%) 40 (80%) 40 (80%) Pigmentation, Hemosiderin 2 (4%) 2 (4%) Renal Tubule, Regeneration 2 (4%) 1 (2%) 1 (2%) Urinary Bladder (50) (50) (50) Hemorrhage 1 (2%) Necrosis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------