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TDMS Study 55323-03 Pathology Tables

NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97
Route: SKIN APPLICATION                                                                                           Time: 12:27:12

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-40-1

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     11           12           22                                                  
    Moribund Sacrifice                                10           12            5                                                  
    Accidently Killed                                  1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           26           22                                                  

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (45)         (46)         (43)                                                
   Intestine Small, Duodenum                          (49)         (49)         (49)                                                
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
   Intestine Small, Jejunum                           (42)         (43)         (38)                                                
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
   Mesentery                                          (5)          (2)          (4)                                                 
      Carcinoma, Metastatic, Urinary Bladder           1 (20%)                                                                      
   Oral Mucosa                                        (1)          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
   Pancreas                                           (50)         (50)         (49)                                                
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Glandular                                 (50)         (50)         (49)                                                
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
   Tongue                                                          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)                                                
   Heart                                              (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Pheochromocytoma Benign                                       1 (2%)                                                          

                                                             Page   2                                                               
NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (50)         (50)         (49)                                                
      Adenoma                                                       2 (4%)                                                          
      Carcinoma                                                                  1 (2%)                                             
   Parathyroid Gland                                  (47)         (40)         (45)                                                
   Pituitary Gland                                    (50)         (50)         (49)                                                
      Pars Distalis, Adenoma                          22 (44%)     30 (60%)     30 (61%)                                            
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  1 (2%)       4 (8%)       3 (6%)                                             
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)       2 (4%)       1 (2%)                                             
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (48)         (48)                                                
      Adenoma                                          7 (14%)      6 (13%)      6 (13%)                                            
      Carcinoma                                        3 (6%)       3 (6%)                                                          
      Bilateral, Adenoma                                                         1 (2%)                                             
   Ovary                                              (50)         (50)         (50)                                                
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                    2 (4%)       5 (10%)      5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (3)          (3)          (1)                                                 
   Lymph Node, Mandibular                             (49)         (50)         (49)                                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
   Thymus                                             (44)         (49)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)       2 (4%)       2 (4%)                                             
      Carcinoma                                                     2 (4%)       3 (6%)                                             
      Fibroadenoma                                    11 (22%)     11 (22%)      9 (18%)                                            
      Fibroadenoma, Multiple                                        1 (2%)                                                          
   Skin                                               (50)         (50)         (50)                                                
      Subcutaneous Tissue, Fibroma                     2 (4%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)                                                                           
      Carcinoma, Metastatic, Urinary Bladder           1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Glioma Malignant                                              1 (2%)                                                          
      Hemangioma                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Lung        1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (49)         (49)         (47)                                                

                                                             Page   4                                                               
NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            10 (20%)      6 (12%)      5 (10%)                                            
      Lymphoma Malignant                               1 (2%)       1 (2%)                                                          
      Mesothelioma Malignant                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          41          38                                                   
     Total Primary Neoplasms                           69          83          70                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 33          39          37                                                   
     Total Benign Neoplasms                            51          69          58                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          13          12                                                   
     Total Malignant Neoplasms                         18          14          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                         12                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                31           29           25                                                  
    Natural Death                                      7            3            8                                                  
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           18           16                                                  

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (50)         (46)                                                
   Intestine Large, Cecum                             (41)         (47)         (44)                                                
   Intestine Small, Duodenum                          (50)         (50)         (50)                                                
   Intestine Small, Jejunum                           (45)         (50)         (46)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (45)         (45)         (44)                                                
   Liver                                              (50)         (50)         (50)                                                
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
   Mesentery                                          (12)         (8)          (6)                                                 
      Lipoma                                                                     1 (17%)                                            
   Oral Mucosa                                                     (1)          (1)                                                 
      Squamous Cell Papilloma                                       1 (100%)     1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)                                                
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Leiomyosarcoma                                   1 (2%)                                                                       
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)                                                
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Pheochromocytoma Malignant                       2 (4%)                                                                       
      Pheochromocytoma Benign                          2 (4%)       2 (4%)       5 (10%)                                            
      Bilateral, Pheochromocytoma Benign                                         2 (4%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          2 (4%)       1 (2%)       4 (8%)                                             
      Adenoma, Multiple                                                          1 (2%)                                             
      Carcinoma                                        4 (8%)       1 (2%)       2 (4%)                                             
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Adenoma                          48 (96%)     45 (90%)     44 (88%)                                            
      Pars Distalis, Adenoma, Multiple                                           2 (4%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  2 (4%)       3 (6%)       2 (4%)                                             
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
   Preputial Gland                                    (50)         (50)         (50)                                                
      Adenoma                                          4 (8%)                    2 (4%)                                             
      Carcinoma                                        2 (4%)       2 (4%)       1 (2%)                                             
   Prostate                                           (50)         (50)         (49)                                                
   Seminal Vesicle                                    (50)         (50)         (49)                                                
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                      20 (40%)     22 (44%)     17 (34%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
   Lymph Node                                         (2)          (4)                                                              
   Lymph Node, Mandibular                             (50)         (50)         (50)                                                
      Sarcoma                                                                    1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (50)                                                

                                                             Page   8                                                               
NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (50)         (50)                                                
      Fibroma                                                       1 (2%)                                                          
   Thymus                                             (44)         (50)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)                                                
      Carcinoma                                                     1 (2%)                                                          
      Fibroadenoma                                     2 (4%)       2 (4%)       2 (4%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Adenoma                               1 (2%)                                                                       
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Keratoacanthoma                                  5 (10%)                   2 (4%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Trichoepithelioma                                1 (2%)                    1 (2%)                                             
      Pinna, Squamous Cell Papilloma                                1 (2%)                                                          
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Basal Cell Adenoma                                                    1 (2%)                                             
      Skin, Site of Application, Squamous Cell                                                                                      
          Papilloma                                                 1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     3 (6%)       5 (10%)      1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)       2 (4%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Myxosarcoma                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Meningioma Benign                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)                                             
      Chordoma, Metastatic, Uncertain Primary Site     1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       

                                                             Page   9                                                               
NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (3)                                                 
      Adenoma                                                                    1 (33%)                                            
      Carcinoma                                                                  2 (67%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Granulocytic                            1 (2%)                                                                       
      Leukemia Mononuclear                             6 (12%)     12 (24%)      8 (16%)                                            
      Lymphoma Malignant                                                         1 (2%)                                             
      Mesothelioma Benign                                                        1 (2%)                                             
      Mesothelioma Malignant                           6 (12%)      3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 55323-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/17/97  
Route: SKIN APPLICATION                                                                                           Time: 12:27:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100                                                    
                                                                             MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          48                                                   
     Total Primary Neoplasms                          117         109         114                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          46          48                                                   
     Total Benign Neoplasms                            92          86          92                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          21          19                                                   
     Total Malignant Neoplasms                         25          23          22                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                                                               
     Total Metastatic Neoplasm                          4           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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