Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/5654

TDMS Study 55323-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                            LAURIC ACID DIETHANOLAMINE CONDENSATE                        DATE: 02/24/98

EXPERIMENT: 55323 TEST: 03                                                                                     TIME: 12:29:58
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55323B
PATHOLOGIST: J. YARRINGTON                                                                                     CAS: 120-40-1
                 

Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                            LAURIC ACID DIETHANOLAMINE CONDENSATE                        DATE: 02/24/98     
EXPERIMENT: 55323 TEST: 03                                                                                     TIME: 12:29:58     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55323B     
PATHOLOGIST: J. YARRINGTON                                                                                     CAS: 120-40-1      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF       LAURIC ACID DIETHANOLAMINE CONDENSATE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Medulla                        Pheochromocytoma Benign
Skin                                   Keratoacanthoma
All Organs                             Mesothelioma: Malignant
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
All Organs                             Benign Tumors
===============================================================
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 1

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        7/50 (14%)    |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.2%             5.3%             18.2%         |  0.0%             2.6%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        5/16 (31%)    |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        641              626              645           |  ---              710              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.067          P=0.677N         P=0.141       |  P=0.718          P=0.507          (e)             |
|POLY 3             |        P=0.038 *        P=0.686          P=0.074       |  P=0.717          P=0.499          (e)             |
|POLY 1.5           |        P=0.038 *        P=0.688          P=0.074       |  P=0.721          P=0.501          (e)             |
|POLY 6             |        P=0.039 *        P=0.685          P=0.078       |  P=0.713          P=0.495          (e)             |
|LOGISTIC REGRESSION|        P=0.048 *        P=0.693          P=0.093       |  P=0.718          P=0.494          (e)             |
|COCH-ARM / FISHERS |        P=0.042 *        P=0.691N         P=0.080       |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/12 (8%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        726              ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.063N         P=0.164N         P=0.175N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.094N         P=0.241N         P=0.235N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.095N         P=0.240N         P=0.239N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.092N         P=0.239N         P=0.225N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.064N         P=0.178N         P=0.170N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095N         P=0.247N         P=0.247N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 2

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        2/50 (4%)        7/50 (14%)    |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        10.4%            5.3%             18.2%         |  0.0%             2.6%             0.0%            |
|TERMINAL (d)       |        1/12 (8%)        1/18 (6%)        5/16 (31%)    |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        641              626              645           |  ---              710              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.275          P=0.274N         P=0.403       |  P=0.718          P=0.507          (e)             |
|POLY 3             |        P=0.180          P=0.348N         P=0.255       |  P=0.717          P=0.499          (e)             |
|POLY 1.5           |        P=0.179          P=0.344N         P=0.250       |  P=0.721          P=0.501          (e)             |
|POLY 6             |        P=0.187          P=0.348N         P=0.269       |  P=0.713          P=0.495          (e)             |
|LOGISTIC REGRESSION|        P=0.214          P=0.344N         P=0.306       |  P=0.718          P=0.494          (e)             |
|COCH-ARM / FISHERS |        P=0.187          P=0.339N         P=0.262       |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        0/50 (0%)        2/50 (4%)     |  7/49 (14%)       6/48 (13%)       7/48 (15%)      |
|POLY-3 ADJUSTED (b)|        10.3%            0.0%             5.3%          |  18.1%            15.7%            20.1%           |
|TERMINAL (d)       |        1/12 (8%)        0/18 (0%)        2/16 (13%)    |  6/27 (22%)       4/25 (16%)       5/21 (24%)      |
|FIRST INCIDENCE    |        589              ---              729 (T)       |  617              627              701             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.179N         P=0.058N         P=0.271N      |  P=0.391          P=0.557N         P=0.435         |
|POLY 3             |        P=0.223N         P=0.065N         P=0.345N      |  P=0.483          P=0.512N         P=0.530         |
|POLY 1.5           |        P=0.225N         P=0.063N         P=0.348N      |  P=0.501          P=0.508N         P=0.551         |
|POLY 6             |        P=0.219N         P=0.067N         P=0.338N      |  P=0.465          P=0.526N         P=0.510         |
|LOGISTIC REGRESSION|        P=0.220N         P=0.062N         P=0.334N      |  P=0.458          P=0.530N         P=0.510         |
|COCH-ARM / FISHERS |        P=0.222N         P=0.059N         P=0.339N      |  P=0.542          P=0.516N         P=0.597         |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 3

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        1/50 (2%)     |  3/49 (6%)        3/48 (6%)        0/48 (0%)       |
|POLY-3 ADJUSTED (b)|        5.2%             5.3%             2.6%          |  7.8%             7.9%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        0/16 (0%)     |  3/27 (11%)       2/25 (8%)        0/21 (0%)       |
|FIRST INCIDENCE    |        500              500              703           |  729 (T)          696              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.355N         P=0.672N         P=0.466N      |  P=0.142N         P=0.636          P=0.167N        |
|POLY 3             |        P=0.396N         P=0.687          P=0.504N      |  P=0.125N         P=0.658          P=0.136N        |
|POLY 1.5           |        P=0.400N         P=0.689          P=0.507N      |  P=0.119N         P=0.659          P=0.132N        |
|POLY 6             |        P=0.384N         P=0.687          P=0.495N      |  P=0.130N         P=0.651          P=0.140N        |
|LOGISTIC REGRESSION|        P=0.367N         P=0.660N         P=0.486N      |  P=0.124N         P=0.643          (e)             |
|COCH-ARM / FISHERS |        P=0.390N         P=0.691N         P=0.500N      |  P=0.105N         P=0.651          P=0.125N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       2/50 (4%)        3/50 (6%)     |  10/49 (20%)      9/48 (19%)       7/48 (15%)      |
|POLY-3 ADJUSTED (b)|        15.1%            5.3%             7.9%          |  25.8%            23.5%            20.1%           |
|TERMINAL (d)       |        1/12 (8%)        1/18 (6%)        2/16 (13%)    |  9/27 (33%)       6/25 (24%)       5/21 (24%)      |
|FIRST INCIDENCE    |        500              500              703           |  617              627              701             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.132N         P=0.124N         P=0.188N      |  P=0.431N         P=0.567N         P=0.492N        |
|POLY 3             |        P=0.177N         P=0.146N         P=0.259N      |  P=0.334N         P=0.512N         P=0.381N        |
|POLY 1.5           |        P=0.177N         P=0.141N         P=0.258N      |  P=0.314N         P=0.508N         P=0.360N        |
|POLY 6             |        P=0.174N         P=0.153N         P=0.255N      |  P=0.354N         P=0.526N         P=0.401N        |
|LOGISTIC REGRESSION|        P=0.169N         P=0.119N         P=0.245N      |  P=0.350N         P=0.546N         P=0.404N        |
|COCH-ARM / FISHERS |        P=0.169N         P=0.134N         P=0.243N      |  P=0.270N         P=0.520N         P=0.314N        |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 4

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        5/50 (10%)    |  0/50 (0%)        2/50 (4%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        5.2%             2.7%             12.9%         |  0.0%             5.1%             0.0%            |
|TERMINAL (d)       |        1/12 (8%)        1/18 (6%)        2/16 (13%)    |  0/28 (0%)        2/26 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        583              729 (T)          603           |  ---              729 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.181          P=0.412N         P=0.295       |  P=0.619          P=0.221          (e)             |
|POLY 3             |        P=0.132          P=0.511N         P=0.218       |  P=0.644          P=0.235          (e)             |
|POLY 1.5           |        P=0.129          P=0.507N         P=0.211       |  P=0.651          P=0.238          (e)             |
|POLY 6             |        P=0.140          P=0.514N         P=0.235       |  P=0.637          P=0.229          (e)             |
|LOGISTIC REGRESSION|        P=0.140          P=0.506N         P=0.220       |  (e)              P=0.221          (e)             |
|COCH-ARM / FISHERS |        P=0.133          P=0.500N         P=0.218       |  P=0.665          P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        1/50 (2%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        10.2%            2.7%             5.2%          |  0.0%             0.0%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        1/16 (6%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        565              729 (T)          683           |  ---              ---              701             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.200N         P=0.162N         P=0.294N      |  P=0.259          (e)              P=0.486         |
|POLY 3             |        P=0.244N         P=0.194N         P=0.348N      |  P=0.269          (e)              P=0.485         |
|POLY 1.5           |        P=0.246N         P=0.188N         P=0.350N      |  P=0.269          (e)              P=0.488         |
|POLY 6             |        P=0.239N         P=0.202N         P=0.340N      |  P=0.270          (e)              P=0.481         |
|LOGISTIC REGRESSION|        P=0.240N         P=0.173N         P=0.334N      |  P=0.256          (e)              P=0.482         |
|COCH-ARM / FISHERS |        P=0.238N         P=0.181N         P=0.339N      |  P=0.266          (e)              P=0.495         |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 5

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       2/50 (4%)        7/50 (14%)    |  0/50 (0%)        2/50 (4%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        15.1%            5.4%             18.0%         |  0.0%             5.1%             2.7%            |
|TERMINAL (d)       |        1/12 (8%)        2/18 (11%)       3/16 (19%)    |  0/28 (0%)        2/26 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        565              729 (T)          603           |  ---              729 (T)          701             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.535          P=0.099N         P=0.604       |  P=0.313          P=0.221          P=0.486         |
|POLY 3             |        P=0.421          P=0.153N         P=0.483       |  P=0.336          P=0.235          P=0.485         |
|POLY 1.5           |        P=0.421          P=0.145N         P=0.480       |  P=0.342          P=0.238          P=0.488         |
|POLY 6             |        P=0.430          P=0.164N         P=0.498       |  P=0.330          P=0.229          P=0.481         |
|LOGISTIC REGRESSION|        P=0.436          P=0.135N         P=0.496       |  P=0.328          P=0.221          P=0.482         |
|COCH-ARM / FISHERS |        P=0.434          P=0.134N         P=0.500       |  P=0.355          P=0.247          P=0.495         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  1/50 (2%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.5%             5.0%             5.5%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  1/28 (4%)        0/26 (0%)        2/22 (9%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  729 (T)          534              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.331          P=0.490          P=0.415         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.366          P=0.506          P=0.473         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.373          P=0.506          P=0.481         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.358          P=0.503          P=0.465         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.376          P=0.496          P=0.415         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.390          P=0.500          P=0.500         |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 6

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.7%             0.0%          |  0.0%             5.1%             8.1%            |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        0/16 (0%)     |  0/28 (0%)        2/26 (8%)        1/22 (5%)       |
|FIRST INCIDENCE    |        ---              729 (T)          ---           |  ---              729 (T)          634             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.703N         P=0.581          (e)           |  P=0.060          P=0.221          P=0.099         |
|POLY 3             |        P=0.729N         P=0.496          (e)           |  P=0.072          P=0.235          P=0.107         |
|POLY 1.5           |        P=0.728          P=0.497          (e)           |  P=0.075          P=0.238          P=0.110         |
|POLY 6             |        P=0.722N         P=0.497          (e)           |  P=0.070          P=0.229          P=0.104         |
|LOGISTIC REGRESSION|        (e)              P=0.581          (e)           |  P=0.069          P=0.221          P=0.110         |
|COCH-ARM / FISHERS |        P=0.731          P=0.500          (e)           |  P=0.082          P=0.247          P=0.121         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  1/50 (2%)        4/50 (8%)        5/50 (10%)      |
|POLY-3 ADJUSTED (b)|        0.0%             2.7%             0.0%          |  2.5%             10.0%            13.5%           |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        0/16 (0%)     |  1/28 (4%)        2/26 (8%)        3/22 (14%)      |
|FIRST INCIDENCE    |        ---              729 (T)          ---           |  729 (T)          534              634             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.703N         P=0.581          (e)           |  P=0.052          P=0.169          P=0.067         |
|POLY 3             |        P=0.729N         P=0.496          (e)           |  P=0.066          P=0.183          P=0.085         |
|POLY 1.5           |        P=0.728          P=0.497          (e)           |  P=0.069          P=0.183          P=0.090         |
|POLY 6             |        P=0.722N         P=0.497          (e)           |  P=0.063          P=0.179          P=0.082         |
|LOGISTIC REGRESSION|        (e)              P=0.581          (e)           |  P=0.067          P=0.180          P=0.082         |
|COCH-ARM / FISHERS |        P=0.731          P=0.500          (e)           |  P=0.080          P=0.181          P=0.102         |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 7

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        2/50 (4%)     |  11/50 (22%)      12/50 (24%)      9/50 (18%)      |
|POLY-3 ADJUSTED (b)|        5.2%             5.3%             5.3%          |  27.0%            28.9%            23.6%           |
|TERMINAL (d)       |        1/12 (8%)        1/18 (6%)        2/16 (13%)    |  8/28 (29%)       6/26 (23%)       5/22 (23%)      |
|FIRST INCIDENCE    |        565              614              729 (T)       |  499              458              535             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.541N         P=0.629N         P=0.623N      |  P=0.534N         P=0.455          P=0.584N        |
|POLY 3             |        P=0.598          P=0.687          P=0.693       |  P=0.422N         P=0.525          P=0.464N        |
|POLY 1.5           |        P=0.594          P=0.689          P=0.688       |  P=0.406N         P=0.523          P=0.447N        |
|POLY 6             |        P=0.593N         P=0.689          P=0.688N      |  P=0.436N         P=0.514          P=0.476N        |
|LOGISTIC REGRESSION|        P=0.594N         P=0.693          P=0.686N      |  P=0.402N         P=0.502          P=0.459N        |
|COCH-ARM / FISHERS |        P=0.601          P=0.691N         P=0.691N      |  P=0.357N         P=0.500          P=0.402N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        2/50 (4%)     |  11/50 (22%)      14/50 (28%)      11/50 (22%)     |
|POLY-3 ADJUSTED (b)|        5.2%             5.3%             5.3%          |  27.0%            32.9%            28.8%           |
|TERMINAL (d)       |        1/12 (8%)        1/18 (6%)        2/16 (13%)    |  8/28 (29%)       6/26 (23%)       7/22 (32%)      |
|FIRST INCIDENCE    |        565              614              729 (T)       |  499              458              535             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.541N         P=0.629N         P=0.623N      |  P=0.363          P=0.295          P=0.396         |
|POLY 3             |        P=0.598          P=0.687          P=0.693       |  P=0.472          P=0.365          P=0.529         |
|POLY 1.5           |        P=0.594          P=0.689          P=0.688       |  P=0.491          P=0.354          P=0.546         |
|POLY 6             |        P=0.593N         P=0.689          P=0.688N      |  P=0.457          P=0.368          P=0.515         |
|LOGISTIC REGRESSION|        P=0.594N         P=0.693          P=0.686N      |  P=0.498          P=0.324          P=0.528         |
|COCH-ARM / FISHERS |        P=0.601          P=0.691N         P=0.691N      |  P=0.547          P=0.322          P=0.595N        |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 8

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        3/50 (6%)        2/50 (4%)     |  11/50 (22%)      16/50 (32%)      13/50 (26%)     |
|POLY-3 ADJUSTED (b)|        5.2%             8.0%             5.3%          |  27.0%            37.6%            33.8%           |
|TERMINAL (d)       |        1/12 (8%)        2/18 (11%)       2/16 (13%)    |  8/28 (29%)       8/26 (31%)       8/22 (36%)      |
|FIRST INCIDENCE    |        565              614              729 (T)       |  499              458              535             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.521N         P=0.601          P=0.623N      |  P=0.203          P=0.167          P=0.225         |
|POLY 3             |        P=0.591          P=0.489          P=0.693       |  P=0.293          P=0.211          P=0.340         |
|POLY 1.5           |        P=0.586          P=0.493          P=0.688       |  P=0.310          P=0.205          P=0.356         |
|POLY 6             |        P=0.585N         P=0.490          P=0.688N      |  P=0.284          P=0.210          P=0.331         |
|LOGISTIC REGRESSION|        P=0.579N         P=0.493          P=0.686N      |  P=0.311          P=0.184          P=0.335         |
|COCH-ARM / FISHERS |        P=0.594          P=0.500          P=0.691N      |  P=0.367          P=0.184          P=0.408         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.6%             2.7%             2.6%          |  0.0%             5.1%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        0/16 (0%)     |  0/28 (0%)        1/26 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        563              729 (T)          727           |  ---              728              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.597N         P=0.730N         P=0.733N      |  P=0.618          P=0.228          (e)             |
|POLY 3             |        P=0.637          P=0.754          P=0.760       |  P=0.642          P=0.235          (e)             |
|POLY 1.5           |        P=0.635          P=0.756          P=0.757       |  P=0.650          P=0.238          (e)             |
|POLY 6             |        P=0.634N         P=0.753          P=0.757N      |  P=0.634          P=0.229          (e)             |
|LOGISTIC REGRESSION|        P=0.639N         P=0.761N         P=0.761N      |  P=0.637          P=0.230          (e)             |
|COCH-ARM / FISHERS |        P=0.640          P=0.753N         P=0.753N      |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 9

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.6%             2.7%             2.6%          |  0.0%             5.1%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        0/16 (0%)     |  0/28 (0%)        1/26 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        563              729 (T)          727           |  ---              728              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.597N         P=0.730N         P=0.733N      |  P=0.618          P=0.228          (e)             |
|POLY 3             |        P=0.637          P=0.754          P=0.760       |  P=0.642          P=0.235          (e)             |
|POLY 1.5           |        P=0.635          P=0.756          P=0.757       |  P=0.650          P=0.238          (e)             |
|POLY 6             |        P=0.634N         P=0.753          P=0.757N      |  P=0.634          P=0.229          (e)             |
|LOGISTIC REGRESSION|        P=0.639N         P=0.761N         P=0.761N      |  P=0.637          P=0.230          (e)             |
|COCH-ARM / FISHERS |        P=0.640          P=0.753N         P=0.753N      |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        48/50 (96%)      45/50 (90%)      46/50 (92%)   |  23/50 (46%)      30/50 (60%)      30/49 (61%)     |
|POLY-3 ADJUSTED (b)|        98.6%            93.6%            96.6%         |  55.8%            69.8%            73.2%           |
|TERMINAL (d)       |        12/12 (100%)     17/18 (94%)      15/16 (94%)   |  16/28 (57%)      19/26 (73%)      17/22 (77%)     |
|FIRST INCIDENCE    |        509              485              513           |  564              489              398             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.170N         P=0.188N         P=0.168N      |  P=0.018 *        P=0.082          P=0.024 *       |
|POLY 3             |        P=0.373N         P=0.174N         P=0.505N      |  P=0.050          P=0.122          P=0.066         |
|POLY 1.5           |        P=0.405N         P=0.186N         P=0.522N      |  P=0.056          P=0.122          P=0.071         |
|POLY 6             |        P=0.313N         P=0.199N         P=0.455N      |  P=0.053          P=0.113          P=0.071         |
|LOGISTIC REGRESSION|        P=0.478N         P=0.286N         P=0.612N      |  P=0.030 *        P=0.089          P=0.041 *       |
|COCH-ARM / FISHERS |        P=0.283N         P=0.218N         P=0.339N      |  P=0.077          P=0.115          P=0.094         |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 10

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             2.6%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/12 (8%)        0/18 (0%)        1/16 (6%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        668              ---              729 (T)       |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.305N         P=0.211N         P=0.425N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.360N         P=0.242N         P=0.500N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.363N         P=0.241N         P=0.505N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.357N         P=0.242N         P=0.488N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.333N         P=0.238N         P=0.463N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.360N         P=0.247N         P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      |
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             5.2%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/12 (8%)        0/18 (0%)        1/16 (6%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        668              ---              703           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.559N         P=0.211N         P=0.618N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.622N         P=0.242N         P=0.694N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.621          P=0.241N         P=0.690       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.618N         P=0.242N         P=0.682N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.591N         P=0.238N         P=0.662N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.622          P=0.247N         P=0.691N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 11

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/50 (14%)       2/50 (4%)        4/50 (8%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        17.9%            5.3%             10.3%         |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        2/12 (17%)       1/18 (6%)        1/16 (6%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        609              646              558           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.144N         P=0.060N         P=0.201N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.182N         P=0.085N         P=0.257N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.188N         P=0.083N         P=0.267N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.169N         P=0.086N         P=0.237N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.184N         P=0.084N         P=0.259N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.187N         P=0.080N         P=0.262N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        5/50 (10%)       1/50 (2%)     |  2/50 (4%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        7.8%             12.9%            2.6%          |  5.0%             2.5%             0.0%            |
|TERMINAL (d)       |        1/12 (8%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        646              597              603           |  479              696              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.246N         P=0.376          P=0.267N      |  P=0.157N         P=0.499N         P=0.261N        |
|POLY 3             |        P=0.257N         P=0.362          P=0.301N      |  P=0.163N         P=0.510N         P=0.260N        |
|POLY 1.5           |        P=0.268N         P=0.357          P=0.308N      |  P=0.156N         P=0.503N         P=0.252N        |
|POLY 6             |        P=0.235N         P=0.379          P=0.286N      |  P=0.171N         P=0.521N         P=0.268N        |
|LOGISTIC REGRESSION|        P=0.263N         P=0.355          P=0.306N      |  P=0.133N         P=0.508N         P=0.213N        |
|COCH-ARM / FISHERS |        P=0.264N         P=0.357          P=0.309N      |  P=0.142N         P=0.500N         P=0.247N        |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 12

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        6/50 (12%)       3/50 (6%)     |  2/50 (4%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        10.3%            15.5%            7.7%          |  5.0%             2.5%             2.7%            |
|TERMINAL (d)       |        1/12 (8%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        563              597              603           |  479              696              465             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.383N         P=0.404          P=0.452N      |  P=0.407N         P=0.499N         P=0.533N        |
|POLY 3             |        P=0.424N         P=0.368          P=0.497N      |  P=0.406N         P=0.510N         P=0.528N        |
|POLY 1.5           |        P=0.438N         P=0.366          P=0.506N      |  P=0.397N         P=0.503N         P=0.520N        |
|POLY 6             |        P=0.396N         P=0.381          P=0.475N      |  P=0.415N         P=0.521N         P=0.538N        |
|LOGISTIC REGRESSION|        P=0.429N         P=0.370          P=0.501N      |  P=0.339N         P=0.508N         P=0.443N        |
|COCH-ARM / FISHERS |        P=0.429N         P=0.370          P=0.500N      |  P=0.378N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        2.6%             2.7%             5.2%          |  0.0%             0.0%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        563              614              654           |  ---              ---              465             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.390          P=0.748          P=0.519       |  P=0.256          (e)              P=0.482         |
|POLY 3             |        P=0.380          P=0.756          P=0.502       |  P=0.272          (e)              P=0.489         |
|POLY 1.5           |        P=0.376          P=0.757          P=0.496       |  P=0.272          (e)              P=0.492         |
|POLY 6             |        P=0.394          P=0.758          P=0.516       |  P=0.272          (e)              P=0.485         |
|LOGISTIC REGRESSION|        P=0.392          P=0.732N         P=0.510       |  P=0.326          (e)              P=0.563         |
|COCH-ARM / FISHERS |        P=0.378          P=0.753N         P=0.500       |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 13

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        2.6%             5.3%             5.2%          |  0.0%             0.0%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        563              614              654           |  ---              ---              465             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.429          P=0.530          P=0.519       |  P=0.256          (e)              P=0.482         |
|POLY 3             |        P=0.392          P=0.492          P=0.502       |  P=0.272          (e)              P=0.489         |
|POLY 1.5           |        P=0.387          P=0.495          P=0.496       |  P=0.272          (e)              P=0.492         |
|POLY 6             |        P=0.411          P=0.494          P=0.516       |  P=0.272          (e)              P=0.485         |
|LOGISTIC REGRESSION|        P=0.393          P=0.512          P=0.510       |  P=0.326          (e)              P=0.563         |
|COCH-ARM / FISHERS |        P=0.390          P=0.500          P=0.500       |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        12.9%            0.0%             5.1%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/12 (8%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        609              ---              558           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.105N         P=0.027N*        P=0.190N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.113N         P=0.033N*        P=0.212N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.116N         P=0.032N*        P=0.220N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.107N         P=0.034N*        P=0.197N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.119N         P=0.034N*        P=0.218N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.118N         P=0.028N*        P=0.218N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 14

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.3%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              646              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.639N         P=0.280          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        P=0.667N         P=0.234          (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.666          P=0.235          (e)           |  (e)              (e)              (e)             |
|POLY 6             |        P=0.654N         P=0.235          (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.662N         P=0.234          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.669          P=0.247          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       2/50 (4%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        12.9%            5.3%             5.1%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/12 (8%)        1/18 (6%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        609              646              558           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.124N         P=0.174N         P=0.190N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.143N         P=0.228N         P=0.212N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.148N         P=0.224N         P=0.220N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.133N         P=0.231N         P=0.197N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.148N         P=0.223N         P=0.218N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.146N         P=0.218N         P=0.218N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 15

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       2/50 (4%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        12.9%            5.3%             5.1%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/12 (8%)        1/18 (6%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        609              646              558           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.124N         P=0.174N         P=0.190N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.143N         P=0.228N         P=0.212N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.148N         P=0.224N         P=0.220N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.133N         P=0.231N         P=0.197N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.148N         P=0.223N         P=0.218N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.146N         P=0.218N         P=0.218N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        20/50 (40%)      22/50 (44%)      17/50 (34%)   |                                                    |
|POLY-3 ADJUSTED (b)|        50.5%            56.0%            42.8%         |                                                    |
|TERMINAL (d)       |        10/12 (83%)      14/18 (78%)      9/16 (56%)    |                                                    |
|FIRST INCIDENCE    |        609              597              555           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.089N         P=0.338N         P=0.109N      |                                                    |
|POLY 3             |        P=0.271N         P=0.389          P=0.315N      |                                                    |
|POLY 1.5           |        P=0.308N         P=0.398          P=0.346N      |                                                    |
|POLY 6             |        P=0.204N         P=0.397          P=0.255N      |                                                    |
|LOGISTIC REGRESSION|        P=0.191N         P=0.349          P=0.226N      |                                                    |
|COCH-ARM / FISHERS |        P=0.304N         P=0.420          P=0.339N      |                                                    |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 16

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        3/50 (6%)        2/50 (4%)     |  1/50 (2%)        4/50 (8%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        5.3%             8.1%             5.2%          |  2.5%             10.0%            8.2%            |
|TERMINAL (d)       |        0/12 (0%)        3/18 (17%)       1/16 (6%)     |  0/28 (0%)        2/26 (8%)        2/22 (9%)       |
|FIRST INCIDENCE    |        708              729 (T)          645           |  707              534              655             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.504N         P=0.624          P=0.629N      |  P=0.195          P=0.182          P=0.242         |
|POLY 3             |        P=0.589N         P=0.489          P=0.691N      |  P=0.220          P=0.180          P=0.279         |
|POLY 1.5           |        P=0.590          P=0.493          P=0.691       |  P=0.230          P=0.182          P=0.286         |
|POLY 6             |        P=0.569N         P=0.488          P=0.677N      |  P=0.212          P=0.175          P=0.272         |
|LOGISTIC REGRESSION|        P=0.542N         P=0.544          P=0.674N      |  P=0.225          P=0.179          P=0.272         |
|COCH-ARM / FISHERS |        P=0.594          P=0.500          P=0.691N      |  P=0.252          P=0.181          P=0.309         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        2/50 (4%)     |  2/50 (4%)        4/50 (8%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        7.9%             8.1%             5.2%          |  5.1%             10.0%            8.2%            |
|TERMINAL (d)       |        1/12 (8%)        3/18 (17%)       1/16 (6%)     |  1/28 (4%)        2/26 (8%)        2/22 (9%)       |
|FIRST INCIDENCE    |        708              729 (T)          645           |  707              534              655             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.312N         P=0.520N         P=0.413N      |  P=0.334          P=0.331          P=0.408         |
|POLY 3             |        P=0.406N         P=0.654          P=0.495N      |  P=0.379          P=0.340          P=0.467         |
|POLY 1.5           |        P=0.416N         P=0.656          P=0.504N      |  P=0.390          P=0.343          P=0.476         |
|POLY 6             |        P=0.385N         P=0.654          P=0.475N      |  P=0.368          P=0.333          P=0.458         |
|LOGISTIC REGRESSION|        P=0.350N         P=0.618N         P=0.460N      |  P=0.380          P=0.334          P=0.454         |
|COCH-ARM / FISHERS |        P=0.412N         P=0.661N         P=0.500N      |  P=0.417          P=0.339          P=0.500         |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 17

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)     |  1/50 (2%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.7%             2.6%          |  2.5%             5.1%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        0/16 (0%)     |  1/28 (4%)        2/26 (8%)        1/22 (5%)       |
|FIRST INCIDENCE    |        ---              729 (T)          632           |  729 (T)          729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.362          P=0.581          P=0.506       |  P=0.546          P=0.474          P=0.708         |
|POLY 3             |        P=0.337          P=0.496          P=0.503       |  P=0.596          P=0.498          P=0.744         |
|POLY 1.5           |        P=0.331          P=0.497          P=0.499       |  P=0.603          P=0.501          P=0.749         |
|POLY 6             |        P=0.354          P=0.497          P=0.513       |  P=0.588          P=0.489          P=0.739         |
|LOGISTIC REGRESSION|        P=0.335          P=0.581          P=0.507       |  P=0.546          P=0.474          P=0.708         |
|COCH-ARM / FISHERS |        P=0.331          P=0.500          P=0.500       |  P=0.622          P=0.500          P=0.753N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)     |  1/50 (2%)        3/50 (6%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.7%             5.2%          |  2.5%             7.7%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        1/18 (6%)        1/16 (6%)     |  1/28 (4%)        3/26 (12%)       1/22 (5%)       |
|FIRST INCIDENCE    |        ---              729 (T)          632           |  729 (T)          729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.168          P=0.581          P=0.275       |  P=0.524          P=0.277          P=0.708         |
|POLY 3             |        P=0.145          P=0.496          P=0.240       |  P=0.575          P=0.302          P=0.744         |
|POLY 1.5           |        P=0.141          P=0.497          P=0.235       |  P=0.586          P=0.306          P=0.749         |
|POLY 6             |        P=0.154          P=0.497          P=0.250       |  P=0.565          P=0.292          P=0.739         |
|LOGISTIC REGRESSION|        P=0.151          P=0.581          P=0.239       |  P=0.524          P=0.277          P=0.708         |
|COCH-ARM / FISHERS |        P=0.142          P=0.500          P=0.247       |  P=0.610          P=0.309          P=0.753N        |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 18

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  2/50 (4%)        5/50 (10%)       5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                                                        |  5.1%             12.4%            13.6%           |
|TERMINAL (d)       |                                                        |  2/28 (7%)        2/26 (8%)        3/22 (14%)      |
|FIRST INCIDENCE    |                                                        |  729 (T)          582              634             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.121          P=0.201          P=0.142         |
|POLY 3             |                                                        |  P=0.150          P=0.224          P=0.187         |
|POLY 1.5           |                                                        |  P=0.158          P=0.224          P=0.195         |
|POLY 6             |                                                        |  P=0.143          P=0.223          P=0.180         |
|LOGISTIC REGRESSION|                                                        |  P=0.151          P=0.217          P=0.172         |
|COCH-ARM / FISHERS |                                                        |  P=0.178          P=0.218          P=0.218         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.1%          |  0.0%             0.0%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        ---              ---              527           |  ---              ---              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.097          (e)              P=0.235       |  P=0.237          (e)              P=0.452         |
|POLY 3             |        P=0.097          (e)              P=0.245       |  P=0.273          (e)              P=0.485         |
|POLY 1.5           |        P=0.095          (e)              P=0.238       |  P=0.272          (e)              P=0.489         |
|POLY 6             |        P=0.103          (e)              P=0.258       |  P=0.274          (e)              P=0.480         |
|LOGISTIC REGRESSION|        P=0.124          (e)              P=0.294       |  (e)              (e)              P=0.452         |
|COCH-ARM / FISHERS |        P=0.095          (e)              P=0.247       |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 19

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       12/50 (24%)      8/50 (16%)    |  10/50 (20%)      6/50 (12%)       5/50 (10%)      |
|POLY-3 ADJUSTED (b)|        15.2%            29.6%            20.0%         |  23.3%            14.8%            13.5%           |
|TERMINAL (d)       |        1/12 (8%)        3/18 (17%)       2/16 (13%)    |  2/28 (7%)        2/26 (8%)        3/22 (14%)      |
|FIRST INCIDENCE    |        506              527              603           |  219              582              594             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.426          P=0.139          P=0.469       |  P=0.166N         P=0.238N         P=0.219N        |
|POLY 3             |        P=0.356          P=0.096          P=0.396       |  P=0.150N         P=0.237N         P=0.202N        |
|POLY 1.5           |        P=0.335          P=0.093          P=0.380       |  P=0.131N         P=0.222N         P=0.176N        |
|POLY 6             |        P=0.407          P=0.109          P=0.434       |  P=0.174N         P=0.262N         P=0.233N        |
|LOGISTIC REGRESSION|        P=0.347          P=0.099          P=0.385       |  P=0.094N         P=0.214N         P=0.126N        |
|COCH-ARM / FISHERS |        P=0.346          P=0.096          P=0.387       |  P=0.097N         P=0.207N         P=0.131N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       3/50 (6%)        2/50 (4%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        15.2%            8.0%             5.2%          |  2.5%             0.0%             0.0%            |
|TERMINAL (d)       |        2/12 (17%)       2/18 (11%)       0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        509              526              632           |  669              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.064N         P=0.166N         P=0.103N      |  P=0.288N         P=0.518N         P=0.525N        |
|POLY 3             |        P=0.091N         P=0.260N         P=0.136N      |  P=0.284N         P=0.503N         P=0.517N        |
|POLY 1.5           |        P=0.094N         P=0.253N         P=0.140N      |  P=0.280N         P=0.500N         P=0.511N        |
|POLY 6             |        P=0.083N         P=0.265N         P=0.126N      |  P=0.289N         P=0.509N         P=0.522N        |
|LOGISTIC REGRESSION|        P=0.090N         P=0.242N         P=0.134N      |  P=0.273N         P=0.500N         P=0.508N        |
|COCH-ARM / FISHERS |        P=0.090N         P=0.243N         P=0.134N      |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 20

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Malignant                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       3/50 (6%)        1/50 (2%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        15.2%            8.0%             2.6%          |  2.5%             0.0%             0.0%            |
|TERMINAL (d)       |        2/12 (17%)       2/18 (11%)       0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        509              526              632           |  669              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.024N*        P=0.166N         P=0.045N*     |  P=0.288N         P=0.518N         P=0.525N        |
|POLY 3             |        P=0.035N*        P=0.260N         P=0.057N      |  P=0.284N         P=0.503N         P=0.517N        |
|POLY 1.5           |        P=0.037N*        P=0.253N         P=0.059N      |  P=0.280N         P=0.500N         P=0.511N        |
|POLY 6             |        P=0.032N*        P=0.265N         P=0.052N      |  P=0.289N         P=0.509N         P=0.522N        |
|LOGISTIC REGRESSION|        P=0.035N*        P=0.242N         P=0.057N      |  P=0.273N         P=0.500N         P=0.508N        |
|COCH-ARM / FISHERS |        P=0.036N*        P=0.243N         P=0.056N      |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        48/50 (96%)      46/50 (92%)      48/50 (96%)   |  33/50 (66%)      39/50 (78%)      37/50 (74%)     |
|POLY-3 ADJUSTED (b)|        98.6%            95.7%            99.9%         |  75.5%            86.5%            87.9%           |
|TERMINAL (d)       |        12/12 (100%)     18/18 (100%)     16/16 (100%)  |  22/28 (79%)      23/26 (89%)      20/22 (91%)     |
|FIRST INCIDENCE    |        509              485              513           |  416              458              398             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.233N         P=0.214N         P=0.232N      |  P=0.045 *        P=0.120          P=0.054         |
|POLY 3             |        P=0.466          P=0.357N         P=0.802       |  P=0.062          P=0.125          P=0.094         |
|POLY 1.5           |        P=0.404          P=0.337N         P=0.567       |  P=0.087          P=0.131          P=0.121         |
|POLY 6             |        P=0.697          P=0.494N         P=1.000       |  P=0.057          P=0.113          P=0.093         |
|LOGISTIC REGRESSION|        P=0.263          P=0.474N         (e)           |  P=0.071          P=0.128          P=0.099         |
|COCH-ARM / FISHERS |        P=0.588          P=0.339N         P=0.691N      |  P=0.216          P=0.133          P=0.257         |
|=================================================================================================================================|
       Date:  02/24/98                           EXPERIMENT: 55323 TEST: 03                                            Page 21

Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -        LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        23/50 (46%)      21/50 (42%)      19/50 (38%)   |  18/50 (36%)      13/50 (26%)      12/50 (24%)     |
|POLY-3 ADJUSTED (b)|        52.3%            48.7%            45.0%         |  40.9%            31.2%            31.3%           |
|TERMINAL (d)       |        5/12 (42%)       6/18 (33%)       7/16 (44%)    |  8/28 (29%)       6/26 (23%)       5/22 (23%)      |
|FIRST INCIDENCE    |        500              430              527           |  219              575              465             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.166N         P=0.312N         P=0.173N      |  P=0.253N         P=0.255N         P=0.303N        |
|POLY 3             |        P=0.279N         P=0.447N         P=0.316N      |  P=0.198N         P=0.235N         P=0.246N        |
|POLY 1.5           |        P=0.282N         P=0.440N         P=0.318N      |  P=0.170N         P=0.218N         P=0.210N        |
|POLY 6             |        P=0.254N         P=0.440N         P=0.292N      |  P=0.229N         P=0.262N         P=0.283N        |
|LOGISTIC REGRESSION|        P=0.237N         P=0.400N         P=0.275N      |  P=0.122N         P=0.195N         P=0.148N        |
|COCH-ARM / FISHERS |        P=0.239N         P=0.420N         P=0.272N      |  P=0.112N         P=0.194N         P=0.138N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        50/50 (100%)     49/50 (98%)      48/50 (96%)   |  40/50 (80%)      41/50 (82%)      38/50 (76%)     |
|POLY-3 ADJUSTED (b)|        100.0%           98.7%            99.9%         |  85.5%            89.1%            88.7%           |
|TERMINAL (d)       |        12/12 (100%)     18/18 (100%)     16/16 (100%)  |  23/28 (82%)      23/26 (89%)      20/22 (91%)     |
|FIRST INCIDENCE    |        500              430              513           |  219              458              398             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.171N         P=0.264N         P=0.168N      |  P=0.246          P=0.375          P=0.272         |
|POLY 3             |        P=0.803N         P=0.719N         P=1.000N      |  P=0.368          P=0.411          P=0.441         |
|POLY 1.5           |        P=0.623N         P=0.601N         P=0.999N      |  P=0.461          P=0.438          P=0.528         |
|POLY 6             |        P=0.937N         P=0.934N         P=1.000N      |  P=0.321          P=0.381          P=0.399         |
|LOGISTIC REGRESSION|        P=0.576N         P=0.510N         (e)           |  P=0.523N         P=0.535          P=0.564N        |
|COCH-ARM / FISHERS |        P=0.142N         P=0.500N         P=0.247N      |  P=0.356N         P=0.500          P=0.405N        |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).