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TDMS Study 55323-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Columbus                            LAURIC ACID DIETHANOLAMINE CONDENSATE                        DATE: 07/28/97

EXPERIMENT: 55323 TEST: 03                                                                                     TIME: 14:26:32
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55323B
PATHOLOGIST: J. YARRINGTON                                                                                     CAS: 120-40-1
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                            LAURIC ACID DIETHANOLAMINE CONDENSATE                        DATE: 07/28/97     
EXPERIMENT: 55323 TEST: 03                                                                                     TIME: 14:26:32     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15314                              ROUTE: SKIN APPLICATION                                        NTP C#: 55323B     
PATHOLOGIST: J. YARRINGTON                                                                                     CAS: 120-40-1      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF  LAURIC ACID DIETHANOLAMINE CONDENSATE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Accessory Adrenal Cortical Nodule
                                       Hyperplasia
Intestine Large, Colon                 Parasite Metazoan
Lung                                   Mineralization
Mesentery: Fat                         Inflammation Chronic
                                       Mineralization
Nose                                   Inflammation
Pancreas: Acinus                       Atrophy
Preputial Gland                        Inflammation Chronic
Skin: Epidermis, Skin, Site of ApplicatHyperplasia
Skin: Sebaceous Gland, Skin, Site of ApHyperplasia
Skin: Skin, Site of Application        Hyperkeratosis
                                       Inflammation Chronic
                                       Parakeratosis
                                       Ulcer
Stomach, Forestomach                   Ulcer
Thymus                                 Atrophy
Thyroid Gland: Follicle                Cyst
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Clitoral Gland                         Inflammation Chronic
Heart: Myocardium                      Inflammation Chronic
Liver                                  Inflammation Chronic
Lung                                   Inflammation Chronic
Lymph Node, Mesenteric                 Pigmentation Lipofuscin
Skin: Epidermis, Skin, Site of ApplicatHyperplasia
Skin: Sebaceous Gland, Skin, Site of ApHyperplasia
Skin: Skin, Site of Application        Hyperkeratosis
                                       Inflammation Chronic
                                       Parakeratosis
                                       Ulcer
Spleen                                 Thrombosis
Stomach, Glandular                     Erosion
===============================================================
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 1

Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        7/50 (14%)       6/50 (12%)    |  2/50 (4%)        2/50 (4%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        2.6%             18.3%            15.4%         |  5.1%             5.0%             8.2%            |
|TERMINAL (d)       |        1/12 (8%)        4/18 (22%)       3/16 (19%)    |  2/28 (7%)        1/26 (4%)        2/22 (9%)       |
|FIRST INCIDENCE    |        729 (T)          614              527           |  729 (T)          458              634             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.098          P=0.064          P=0.106       |  P=0.323          P=0.678          P=0.402         |
|POLY 3             |        P=0.063          P=0.029 *        P=0.058       |  P=0.384          P=0.690N         P=0.469         |
|POLY 1.5           |        P=0.058          P=0.029 *        P=0.055       |  P=0.390          P=0.689N         P=0.477         |
|POLY 6             |        P=0.077          P=0.030 *        P=0.067       |  P=0.378          P=0.694          P=0.461         |
|LOGISTIC REGRESSION|        P=0.065          P=0.030 *        P=0.061       |  P=0.384          P=0.695N         P=0.454         |
|COCH-ARM / FISHERS |        P=0.061          P=0.030 *        P=0.056       |  P=0.406          P=0.691N         P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  5.1%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  2/28 (7%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  729 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.118N         P=0.254N         P=0.292N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.101N         P=0.238N         P=0.254N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.099N         P=0.236N         P=0.249N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.103N         P=0.243N         P=0.260N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.118N         (e)              (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.095N         P=0.247N         P=0.247N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 2

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  5.0%             5.1%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  1/28 (4%)        1/26 (4%)        1/22 (5%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  499              605              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.455N         P=0.678          P=0.561N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.433N         P=0.690          P=0.533N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.419N         P=0.694          P=0.522N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.447N         P=0.682          P=0.544N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.397N         P=0.693          P=0.506N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.390N         P=0.691N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        3/50 (6%)     |  1/50 (2%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             7.8%          |  2.5%             5.1%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        1/16 (6%)     |  1/28 (4%)        2/26 (8%)        1/22 (5%)       |
|FIRST INCIDENCE    |        ---              ---              703           |  729 (T)          729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.054          (e)              P=0.182       |  P=0.546          P=0.474          P=0.708         |
|POLY 3             |        P=0.035 *        (e)              P=0.119       |  P=0.596          P=0.498          P=0.744         |
|POLY 1.5           |        P=0.035 *        (e)              P=0.117       |  P=0.603          P=0.501          P=0.749         |
|POLY 6             |        P=0.037 *        (e)              P=0.126       |  P=0.588          P=0.489          P=0.739         |
|LOGISTIC REGRESSION|        P=0.046 *        (e)              P=0.145       |  P=0.546          P=0.474          P=0.708         |
|COCH-ARM / FISHERS |        P=0.037 *        (e)              P=0.121       |  P=0.622          P=0.500          P=0.753N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 3

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        19/50 (38%)      21/50 (42%)      22/50 (44%)   |  5/50 (10%)       4/50 (8%)        7/50 (14%)      |
|POLY-3 ADJUSTED (b)|        45.1%            50.0%            53.3%         |  12.4%            10.2%            19.2%           |
|TERMINAL (d)       |        3/12 (25%)       9/18 (50%)       9/16 (56%)    |  3/28 (11%)       3/26 (12%)       6/22 (27%)      |
|FIRST INCIDENCE    |        500              485              513           |  374              645              703             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.523          P=0.559          P=0.562N      |  P=0.198          P=0.539N         P=0.245         |
|POLY 3             |        P=0.254          P=0.406          P=0.291       |  P=0.262          P=0.515N         P=0.307         |
|POLY 1.5           |        P=0.259          P=0.412          P=0.295       |  P=0.278          P=0.505N         P=0.330         |
|POLY 6             |        P=0.260          P=0.395          P=0.302       |  P=0.246          P=0.532N         P=0.286         |
|LOGISTIC REGRESSION|        P=0.295          P=0.406          P=0.337       |  P=0.262          P=0.500N         P=0.325         |
|COCH-ARM / FISHERS |        P=0.306          P=0.419          P=0.342       |  P=0.314          P=0.500N         P=0.380         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        10.5%            5.4%             2.6%          |  0.0%             0.0%             2.7%            |
|TERMINAL (d)       |        2/12 (17%)       1/18 (6%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        626              658              717           |  ---              ---              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.078N         P=0.258N         P=0.121N      |  P=0.237          (e)              P=0.452         |
|POLY 3             |        P=0.116N         P=0.347N         P=0.177N      |  P=0.273          (e)              P=0.485         |
|POLY 1.5           |        P=0.121N         P=0.344N         P=0.182N      |  P=0.272          (e)              P=0.489         |
|POLY 6             |        P=0.109N         P=0.346N         P=0.166N      |  P=0.274          (e)              P=0.480         |
|LOGISTIC REGRESSION|        P=0.103N         P=0.340N         P=0.155N      |  (e)              (e)              P=0.452         |
|COCH-ARM / FISHERS |        P=0.118N         P=0.339N         P=0.181N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 4

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel                                                                                                                     |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.2%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              717           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.137          (e)              P=0.344       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.095          (e)              P=0.238       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.094          (e)              P=0.235       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.098          (e)              P=0.247       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.111          (e)              P=0.272       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095          (e)              P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             5.1%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        2/26 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              729 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.619          P=0.221          (e)             |
|POLY 3             |        (e)              (e)              (e)           |  P=0.642          P=0.235          (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.650          P=0.238          (e)             |
|POLY 6             |        (e)              (e)              (e)           |  P=0.634          P=0.229          (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              P=0.221          (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 5

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             5.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              489              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.663          P=0.258          (e)             |
|POLY 3             |        (e)              (e)              (e)           |  P=0.642          P=0.242          (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.650          P=0.242          (e)             |
|POLY 6             |        (e)              (e)              (e)           |  P=0.634          P=0.240          (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.609N         P=0.202          (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.669          P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  4/49 (8%)        0/48 (0%)        1/48 (2%)       |
|POLY-3 ADJUSTED (b)|                                                        |  10.4%            0.0%             2.9%            |
|TERMINAL (d)       |                                                        |  3/27 (11%)       0/25 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |                                                        |  707              ---              684             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.113N         P=0.071N         P=0.247N        |
|POLY 3             |                                                        |  P=0.089N         P=0.061N         P=0.208N        |
|POLY 1.5           |                                                        |  P=0.087N         P=0.061N         P=0.201N        |
|POLY 6             |                                                        |  P=0.090N         P=0.064N         P=0.213N        |
|LOGISTIC REGRESSION|                                                        |  P=0.098N         P=0.067N         P=0.217N        |
|COCH-ARM / FISHERS |                                                        |  P=0.085N         P=0.061N         P=0.187N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 6

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  30/49 (61%)      34/48 (71%)      36/48 (75%)     |
|POLY-3 ADJUSTED (b)|                                                        |  67.9%            76.0%            81.9%           |
|TERMINAL (d)       |                                                        |  15/27 (56%)      22/25 (88%)      18/21 (86%)     |
|FIRST INCIDENCE    |                                                        |  416              238              36              |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.035 *        P=0.218          P=0.053         |
|POLY 3             |                                                        |  P=0.072          P=0.264          P=0.092         |
|POLY 1.5           |                                                        |  P=0.087          P=0.273          P=0.107         |
|POLY 6             |                                                        |  P=0.048 *        P=0.209          P=0.067         |
|LOGISTIC REGRESSION|                                                        |  P=0.078          P=0.223          P=0.093         |
|COCH-ARM / FISHERS |                                                        |  P=0.087          P=0.217          P=0.108         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/0 (0%)         1/1 (100%)       1/2 (50%)     |  1/1 (100%)       0/1 (0%)         3/6 (50%)       |
|POLY-3 ADJUSTED (b)|        0.0%             100.0%           52.7%         |  100.0%           0.0%             58.3%           |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)      |  0/0 (0%)         0/0 (0%)         1/2 (50%)       |
|FIRST INCIDENCE    |        ---              626              670           |  707              ---              701             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.329          P=0.514N         P=0.457         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.542N         P=1.000          P=0.631N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.509N         P=1.000          P=0.608N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.571N         P=1.000          P=0.646N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.411N         (e)              P=0.621N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.500N         P=0.500N         P=0.571N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 7

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        1/50 (2%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        5.2%             0.0%             5.2%          |  0.0%             2.6%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        618              ---              717           |  ---              728              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.545N         P=0.237N         P=0.601N      |  P=0.701          P=0.493          (e)             |
|POLY 3             |        P=0.622          P=0.243N         P=0.694       |  P=0.713          P=0.499          (e)             |
|POLY 1.5           |        P=0.620          P=0.241N         P=0.689       |  P=0.718          P=0.501          (e)             |
|POLY 6             |        P=0.619N         P=0.245N         P=0.686N      |  P=0.708          P=0.494          (e)             |
|LOGISTIC REGRESSION|        P=0.610N         P=0.240N         P=0.684N      |  P=0.708          P=0.494          (e)             |
|COCH-ARM / FISHERS |        P=0.622          P=0.247N         P=0.691N      |  P=0.728          P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Myocardium                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        36/50 (72%)      39/50 (78%)      41/50 (82%)   |  27/50 (54%)      31/50 (62%)      35/49 (71%)     |
|POLY-3 ADJUSTED (b)|        76.9%            86.6%            85.6%         |  62.9%            72.2%            82.4%           |
|TERMINAL (d)       |        9/12 (75%)       18/18 (100%)     14/16 (88%)   |  18/28 (64%)      20/26 (77%)      19/21 (91%)     |
|FIRST INCIDENCE    |        500              526              266           |  471              458              347             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.523N         P=0.461N         P=0.549N      |  P=0.007 **       P=0.200          P=0.010 *       |
|POLY 3             |        P=0.140          P=0.149          P=0.192       |  P=0.020 *        P=0.234          P=0.028 *       |
|POLY 1.5           |        P=0.121          P=0.216          P=0.161       |  P=0.027 *        P=0.264          P=0.034 *       |
|POLY 6             |        P=0.183          P=0.084          P=0.247       |  P=0.013 *        P=0.179          P=0.020 *       |
|LOGISTIC REGRESSION|        P=0.116          P=0.280          P=0.167       |  P=0.015 *        P=0.261          P=0.023 *       |
|COCH-ARM / FISHERS |        P=0.141          P=0.322          P=0.171       |  P=0.046 *        P=0.272          P=0.056         |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 8

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/49 (8%)        0/50 (0%)        0/46 (0%)     |  2/45 (4%)        4/46 (9%)        3/43 (7%)       |
|POLY-3 ADJUSTED (b)|        10.7%            0.0%             0.0%          |  5.5%             10.6%            8.8%            |
|TERMINAL (d)       |        2/12 (17%)       0/18 (0%)        0/16 (0%)     |  2/28 (7%)        1/26 (4%)        2/22 (9%)       |
|FIRST INCIDENCE    |        609              ---              ---           |  729 (T)          605              507             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.010N*        P=0.043N*        P=0.047N*     |  P=0.334          P=0.312          P=0.410         |
|POLY 3             |        P=0.014N*        P=0.060N         P=0.068N      |  P=0.387          P=0.358          P=0.473         |
|POLY 1.5           |        P=0.015N*        P=0.059N         P=0.071N      |  P=0.387          P=0.360          P=0.473         |
|POLY 6             |        P=0.014N*        P=0.060N         P=0.063N      |  P=0.386          P=0.350          P=0.473         |
|LOGISTIC REGRESSION|        P=0.015N*        P=0.061N         P=0.067N      |  P=0.384          P=0.349          P=0.468         |
|COCH-ARM / FISHERS |        P=0.016N*        P=0.056N         P=0.067N      |  P=0.394          P=0.349          P=0.478         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/48 (4%)        2/49 (4%)        5/47 (11%)    |  2/42 (5%)        2/45 (4%)        1/43 (2%)       |
|POLY-3 ADJUSTED (b)|        5.6%             5.5%             13.6%         |  5.6%             5.5%             3.1%            |
|TERMINAL (d)       |        2/12 (17%)       2/18 (11%)       2/16 (13%)    |  1/28 (4%)        2/26 (8%)        1/22 (5%)       |
|FIRST INCIDENCE    |        729 (T)          729 (T)          583           |  640              729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.200          P=0.543N         P=0.297       |  P=0.472N         P=0.658          P=0.576N        |
|POLY 3             |        P=0.146          P=0.692N         P=0.221       |  P=0.431N         P=0.690N         P=0.531N        |
|POLY 1.5           |        P=0.139          P=0.691N         P=0.208       |  P=0.414N         P=0.679N         P=0.518N        |
|POLY 6             |        P=0.164          P=0.690N         P=0.249       |  P=0.451N         P=0.683          P=0.546N        |
|LOGISTIC REGRESSION|        P=0.155          P=0.543N         P=0.217       |  P=0.426N         P=0.693N         P=0.525N        |
|COCH-ARM / FISHERS |        P=0.139          P=0.684N         P=0.209       |  P=0.381N         P=0.665N         P=0.491N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 9

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/50 (14%)       4/50 (8%)        6/50 (12%)    |  2/50 (4%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        18.1%            10.6%            15.7%         |  5.1%             0.0%             5.5%            |
|TERMINAL (d)       |        3/12 (25%)       2/18 (11%)       4/16 (25%)    |  2/28 (7%)        0/26 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        641              613              703           |  729 (T)          ---              680             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.296N         P=0.182N         P=0.323N      |  P=0.557          P=0.254N         P=0.619         |
|POLY 3             |        P=0.443N         P=0.271N         P=0.508N      |  P=0.616          P=0.238N         P=0.669         |
|POLY 1.5           |        P=0.449N         P=0.268N         P=0.515N      |  P=0.618          P=0.236N         P=0.676         |
|POLY 6             |        P=0.428N         P=0.269N         P=0.491N      |  P=0.614          P=0.243N         P=0.662         |
|LOGISTIC REGRESSION|        P=0.377N         P=0.265N         P=0.417N      |  P=0.587          (e)              P=0.656         |
|COCH-ARM / FISHERS |        P=0.437N         P=0.262N         P=0.500N      |  P=0.622          P=0.247N         P=0.691N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             0.0%          |  0.0%             0.0%             5.4%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        565              ---              ---           |  ---              ---              465             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.282N         P=0.519N         P=0.514N      |  P=0.083          (e)              P=0.213         |
|POLY 3             |        P=0.271N         P=0.507N         P=0.501N      |  P=0.094          (e)              P=0.224         |
|POLY 1.5           |        P=0.273N         P=0.504N         P=0.504N      |  P=0.094          (e)              P=0.228         |
|POLY 6             |        P=0.270N         P=0.508N         P=0.496N      |  P=0.093          (e)              P=0.221         |
|LOGISTIC REGRESSION|        P=0.216N         P=0.446N         P=0.452N      |  P=0.105          (e)              P=0.250         |
|COCH-ARM / FISHERS |        P=0.269N         P=0.500N         P=0.500N      |  P=0.095          (e)              P=0.247         |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 10

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        3/50 (6%)     |  24/50 (48%)      23/50 (46%)      27/50 (54%)     |
|POLY-3 ADJUSTED (b)|        2.6%             2.7%             7.6%          |  53.0%            49.4%            58.5%           |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  15/28 (54%)      7/26 (27%)       9/22 (41%)      |
|FIRST INCIDENCE    |        624              625              513           |  322              238              36              |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.230          P=0.750          P=0.352       |  P=0.174          P=0.552N         P=0.176         |
|POLY 3             |        P=0.208          P=0.757          P=0.314       |  P=0.333          P=0.445N         P=0.374         |
|POLY 1.5           |        P=0.202          P=0.758          P=0.305       |  P=0.321          P=0.464N         P=0.360         |
|POLY 6             |        P=0.221          P=0.759          P=0.332       |  P=0.363          P=0.409N         P=0.409         |
|LOGISTIC REGRESSION|        P=0.224          P=0.753N         P=0.333       |  P=0.393          P=0.509N         P=0.417         |
|COCH-ARM / FISHERS |        P=0.202          P=0.753N         P=0.309       |  P=0.309          P=0.500N         P=0.345         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        42/50 (84%)      40/50 (80%)      40/50 (80%)   |  40/50 (80%)      41/50 (82%)      40/50 (80%)     |
|POLY-3 ADJUSTED (b)|        91.4%            89.3%            90.3%         |  91.3%            91.4%            93.3%           |
|TERMINAL (d)       |        12/12 (100%)     18/18 (100%)     16/16 (100%)  |  28/28 (100%)     26/26 (100%)     22/22 (100%)    |
|FIRST INCIDENCE    |        509              485              522           |  475              489              347             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.137N         P=0.181N         P=0.142N      |  P=0.101          P=0.324          P=0.115         |
|POLY 3             |        P=0.497N         P=0.510N         P=0.590N      |  P=0.430          P=0.676          P=0.528         |
|POLY 1.5           |        P=0.477N         P=0.453N         P=0.550N      |  P=0.456          P=0.621          P=0.533         |
|POLY 6             |        P=0.484N         P=0.643N         P=0.623N      |  P=0.419          P=0.701          P=0.553         |
|LOGISTIC REGRESSION|        P=0.395N         P=0.549N         P=0.455N      |  P=0.248          P=0.612          P=0.313         |
|COCH-ARM / FISHERS |        P=0.350N         P=0.398N         P=0.398N      |  P=0.550          P=0.500          P=0.598N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 11

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        0/50 (0%)     |  2/50 (4%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        5.3%             5.4%             0.0%          |  5.0%             5.1%             5.5%            |
|TERMINAL (d)       |        0/12 (0%)        2/18 (11%)       0/16 (0%)     |  1/28 (4%)        1/26 (4%)        2/22 (9%)       |
|FIRST INCIDENCE    |        710              729 (T)          ---           |  564              717              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.122N         P=0.583N         P=0.189N      |  P=0.527          P=0.684          P=0.623         |
|POLY 3             |        P=0.174N         P=0.688          P=0.235N      |  P=0.570          P=0.688          P=0.662         |
|POLY 1.5           |        P=0.179N         P=0.689          P=0.239N      |  P=0.579          P=0.693          P=0.672         |
|POLY 6             |        P=0.164N         P=0.689          P=0.226N      |  P=0.558          P=0.677          P=0.650         |
|LOGISTIC REGRESSION|        P=0.129N         P=0.658N         P=0.199N      |  P=0.568          P=0.694          P=0.672         |
|COCH-ARM / FISHERS |        P=0.176N         P=0.691N         P=0.247N      |  P=0.601          P=0.691N         P=0.691N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Regeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        1/50 (2%)     |  2/50 (4%)        4/50 (8%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        5.2%             2.7%             2.6%          |  5.1%             10.1%            5.5%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  2/28 (7%)        2/26 (8%)        2/22 (9%)       |
|FIRST INCIDENCE    |        589              526              589           |  729 (T)          645              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.379N         P=0.511N         P=0.496N      |  P=0.492          P=0.308          P=0.607         |
|POLY 3             |        P=0.379N         P=0.508N         P=0.500N      |  P=0.547          P=0.338          P=0.667         |
|POLY 1.5           |        P=0.383N         P=0.505N         P=0.505N      |  P=0.559          P=0.341          P=0.675         |
|POLY 6             |        P=0.371N         P=0.510N         P=0.489N      |  P=0.535          P=0.331          P=0.658         |
|LOGISTIC REGRESSION|        P=0.311N         P=0.443N         P=0.467N      |  P=0.538          P=0.322          P=0.607         |
|COCH-ARM / FISHERS |        P=0.378N         P=0.500N         P=0.500N      |  P=0.588          P=0.339          P=0.691N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 12

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  1/50 (2%)        3/50 (6%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.5%             7.6%             5.5%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  1/28 (4%)        2/26 (8%)        2/22 (9%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  729 (T)          534              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.320          P=0.293          P=0.415         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.366          P=0.307          P=0.473         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.376          P=0.309          P=0.481         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.355          P=0.301          P=0.465         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.367          P=0.304          P=0.415         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.399          P=0.309          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        3/50 (6%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             0.0%          |  0.0%             7.7%             5.5%            |
|TERMINAL (d)       |        1/12 (8%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        3/26 (12%)       2/22 (9%)       |
|FIRST INCIDENCE    |        729 (T)          ---              ---           |  ---              729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.225N         P=0.419N         P=0.443N      |  P=0.140          P=0.107          P=0.186         |
|POLY 3             |        P=0.270N         P=0.504N         P=0.499N      |  P=0.176          P=0.116          P=0.220         |
|POLY 1.5           |        P=0.272N         P=0.503N         P=0.502N      |  P=0.183          P=0.119          P=0.225         |
|POLY 6             |        P=0.271N         P=0.503N         P=0.491N      |  P=0.168          P=0.112          P=0.214         |
|LOGISTIC REGRESSION|        P=0.225N         (e)              (e)           |  (e)              P=0.107          P=0.186         |
|COCH-ARM / FISHERS |        P=0.269N         P=0.500N         P=0.500N      |  P=0.202          P=0.121          P=0.247         |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 13

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       8/50 (16%)       6/50 (12%)    |  12/50 (24%)      17/50 (34%)      12/50 (24%)     |
|POLY-3 ADJUSTED (b)|        13.0%            20.5%            15.7%         |  28.0%            39.5%            30.5%           |
|TERMINAL (d)       |        1/12 (8%)        4/18 (22%)       4/16 (25%)    |  5/28 (18%)       11/26 (42%)      7/22 (32%)      |
|FIRST INCIDENCE    |        641              500              719           |  374              238              347             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.536N         P=0.378          P=0.577N      |  P=0.357          P=0.178          P=0.422         |
|POLY 3             |        P=0.431          P=0.279          P=0.494       |  P=0.429          P=0.182          P=0.497         |
|POLY 1.5           |        P=0.425          P=0.277          P=0.487       |  P=0.472          P=0.195          P=0.533         |
|POLY 6             |        P=0.449          P=0.289          P=0.510       |  P=0.374          P=0.157          P=0.452         |
|LOGISTIC REGRESSION|        P=0.460          P=0.267          P=0.586       |  P=0.525N         P=0.183          P=0.580N        |
|COCH-ARM / FISHERS |        P=0.440          P=0.277          P=0.500       |  P=0.545          P=0.189          P=0.592N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       4/50 (8%)        3/50 (6%)     |  13/50 (26%)      15/50 (30%)      4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        15.2%            10.7%            7.8%          |  30.8%            35.3%            10.9%           |
|TERMINAL (d)       |        2/12 (17%)       3/18 (17%)       2/16 (13%)    |  8/28 (29%)       9/26 (35%)       2/22 (9%)       |
|FIRST INCIDENCE    |        509              646              589           |  475              403              655             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.121N         P=0.247N         P=0.172N      |  P=0.060N         P=0.366          P=0.049N*       |
|POLY 3             |        P=0.192N         P=0.400N         P=0.249N      |  P=0.041N*        P=0.416          P=0.028N*       |
|POLY 1.5           |        P=0.196N         P=0.388N         P=0.253N      |  P=0.030N*        P=0.425          P=0.022N*       |
|POLY 6             |        P=0.180N         P=0.411N         P=0.235N      |  P=0.055N         P=0.392          P=0.035N*       |
|LOGISTIC REGRESSION|        P=0.185N         P=0.379N         P=0.245N      |  P=0.022N*        P=0.412          P=0.020N*       |
|COCH-ARM / FISHERS |        P=0.187N         P=0.370N         P=0.243N      |  P=0.019N*        P=0.412          P=0.016N*       |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 14

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        4/50 (8%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             5.1%          |  0.0%             10.0%            0.0%            |
|TERMINAL (d)       |        1/12 (8%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        2/26 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        680              ---              555           |  ---              582              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.587N         P=0.204N         P=0.652N      |  P=0.578          P=0.062          (e)             |
|POLY 3             |        P=0.619N         P=0.242N         P=0.686N      |  P=0.578          P=0.061          (e)             |
|POLY 1.5           |        P=0.622          P=0.240N         P=0.694       |  P=0.592          P=0.062          (e)             |
|POLY 6             |        P=0.612N         P=0.242N         P=0.668N      |  P=0.564          P=0.060          (e)             |
|LOGISTIC REGRESSION|        P=0.621N         P=0.235N         P=0.694N      |  P=0.616          P=0.063          (e)             |
|COCH-ARM / FISHERS |        P=0.622          P=0.247N         P=0.691N      |  P=0.622          P=0.059          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      14/50 (28%)      15/50 (30%)   |  3/50 (6%)        6/50 (12%)       2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        26.9%            34.6%            36.9%         |  7.6%             15.2%            5.5%            |
|TERMINAL (d)       |        2/12 (17%)       6/18 (33%)       7/16 (44%)    |  1/28 (4%)        4/26 (15%)       2/22 (9%)       |
|FIRST INCIDENCE    |        535              485              522           |  669              623              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.353          P=0.440          P=0.396       |  P=0.531N         P=0.219          P=0.586N        |
|POLY 3             |        P=0.195          P=0.301          P=0.229       |  P=0.491N         P=0.236          P=0.540N        |
|POLY 1.5           |        P=0.193          P=0.309          P=0.225       |  P=0.469N         P=0.243          P=0.527N        |
|POLY 6             |        P=0.211          P=0.298          P=0.247       |  P=0.516N         P=0.223          P=0.555N        |
|LOGISTIC REGRESSION|        P=0.208          P=0.322          P=0.240       |  P=0.479N         P=0.229          P=0.546N        |
|COCH-ARM / FISHERS |        P=0.214          P=0.322          P=0.247       |  P=0.424N         P=0.243          P=0.500N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 15

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/50 (14%)       6/50 (12%)       6/50 (12%)    |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        18.0%            15.6%            15.1%         |  0.0%             2.5%             0.0%            |
|TERMINAL (d)       |        3/12 (25%)       1/18 (6%)        2/16 (13%)    |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        565              626              513           |  ---              605              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.355N         P=0.445N         P=0.390N      |  P=0.711          P=0.484          (e)             |
|POLY 3             |        P=0.421N         P=0.505N         P=0.481N      |  P=0.717          P=0.501          (e)             |
|POLY 1.5           |        P=0.440N         P=0.506N         P=0.500N      |  P=0.721          P=0.502          (e)             |
|POLY 6             |        P=0.385N         P=0.491N         P=0.443N      |  P=0.713          P=0.498          (e)             |
|LOGISTIC REGRESSION|        P=0.443N         P=0.514N         P=0.503N      |  P=0.721N         P=0.494          (e)             |
|COCH-ARM / FISHERS |        P=0.440N         P=0.500N         P=0.500N      |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        1/50 (2%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             2.5%             7.8%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              634              361             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.055          P=0.472          P=0.111         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.057          P=0.500          P=0.113         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.058          P=0.502          P=0.114         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.057          P=0.497          P=0.112         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.086          P=0.498          P=0.159         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.060          P=0.500          P=0.121         |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 16

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.6%          |  0.0%             0.0%             5.2%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              106           |  ---              ---              36              |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.270          (e)              P=0.500       |  P=0.092          (e)              P=0.233         |
|POLY 3             |        P=0.276          (e)              P=0.507       |  P=0.094          (e)              P=0.230         |
|POLY 1.5           |        P=0.272          (e)              P=0.502       |  P=0.094          (e)              P=0.233         |
|POLY 6             |        P=0.283          (e)              P=0.516       |  P=0.093          (e)              P=0.227         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.205          (e)              P=0.407         |
|COCH-ARM / FISHERS |        P=0.269          (e)              P=0.500       |  P=0.095          (e)              P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        4/50 (8%)     |  2/50 (4%)        2/50 (4%)        8/50 (16%)      |
|POLY-3 ADJUSTED (b)|        2.6%             8.1%             10.2%         |  5.1%             5.0%             21.8%           |
|TERMINAL (d)       |        1/12 (8%)        2/18 (11%)       0/16 (0%)     |  2/28 (7%)        0/26 (0%)        7/22 (32%)      |
|FIRST INCIDENCE    |        729 (T)          719              589           |  729 (T)          605              634             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.188          P=0.456          P=0.223       |  P=0.009 **       P=0.659          P=0.017 *       |
|POLY 3             |        P=0.142          P=0.297          P=0.188       |  P=0.015 *        P=0.691N         P=0.032 *       |
|POLY 1.5           |        P=0.133          P=0.300          P=0.179       |  P=0.017 *        P=0.689N         P=0.036 *       |
|POLY 6             |        P=0.162          P=0.297          P=0.208       |  P=0.014 *        P=0.694N         P=0.029 *       |
|LOGISTIC REGRESSION|        P=0.139          P=0.371          P=0.178       |  P=0.014 *        P=0.695N         P=0.028 *       |
|COCH-ARM / FISHERS |        P=0.133          P=0.309          P=0.181       |  P=0.021 *        P=0.691N         P=0.046 *       |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 17

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        21/50 (42%)      22/50 (44%)      34/50 (68%)   |  23/50 (46%)      18/50 (36%)      19/50 (38%)     |
|POLY-3 ADJUSTED (b)|        51.4%            52.2%            75.6%         |  54.0%            42.8%            47.9%           |
|TERMINAL (d)       |        8/12 (67%)       11/18 (61%)      12/16 (75%)   |  17/28 (61%)      10/26 (39%)      10/22 (46%)     |
|FIRST INCIDENCE    |        563              485              513           |  322              518              323             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.081          P=0.414N         P=0.123       |  P=0.511N         P=0.300N         P=0.573N        |
|POLY 3             |        P=0.007 **       P=0.560          P=0.010 *     |  P=0.314N         P=0.202N         P=0.367N        |
|POLY 1.5           |        P=0.005 **       P=0.531          P=0.006 **    |  P=0.292N         P=0.201N         P=0.339N        |
|POLY 6             |        P=0.018 *        P=0.597N         P=0.029 *     |  P=0.336N         P=0.207N         P=0.396N        |
|LOGISTIC REGRESSION|        P=0.005 **       P=0.466          P=0.005 **    |  P=0.295N         P=0.202N         P=0.336N        |
|COCH-ARM / FISHERS |        P=0.006 **       P=0.500          P=0.008 **    |  P=0.237N         P=0.208N         P=0.272N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Interstitium                                                                                                               |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)     |  2/50 (4%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.4%             0.0%          |  5.1%             5.1%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        2/18 (11%)       0/16 (0%)     |  2/28 (7%)        1/26 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              729 (T)          ---           |  729 (T)          717              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.618N         P=0.330          (e)           |  P=0.222N         P=0.674          P=0.292N        |
|POLY 3             |        P=0.667N         P=0.232          (e)           |  P=0.200N         P=0.693          P=0.254N        |
|POLY 1.5           |        P=0.666          P=0.234          (e)           |  P=0.193N         P=0.693N         P=0.249N        |
|POLY 6             |        P=0.654N         P=0.231          (e)           |  P=0.208N         P=0.685          P=0.260N        |
|LOGISTIC REGRESSION|        (e)              P=0.330          (e)           |  P=0.202N         P=0.683          (e)             |
|COCH-ARM / FISHERS |        P=0.669          P=0.247          (e)           |  P=0.176N         P=0.691N         P=0.247N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 18

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        5.2%             0.0%             2.6%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        618              ---              696           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.341N         P=0.248N         P=0.471N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.361N         P=0.244N         P=0.501N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.364N         P=0.241N         P=0.505N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.357N         P=0.245N         P=0.490N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.360N         P=0.239N         P=0.500N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.360N         P=0.247N         P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        2.6%             5.4%             2.6%          |  0.0%             2.6%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        2/18 (11%)       1/16 (6%)     |  0/28 (0%)        1/26 (4%)        1/22 (5%)       |
|FIRST INCIDENCE    |        674              729 (T)          729 (T)       |  ---              729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.551N         P=0.584          P=0.716N      |  P=0.281          P=0.485          P=0.452         |
|POLY 3             |        P=0.621N         P=0.491          P=0.761N      |  P=0.318          P=0.499          P=0.485         |
|POLY 1.5           |        P=0.617          P=0.494          P=0.758       |  P=0.323          P=0.501          P=0.489         |
|POLY 6             |        P=0.610N         P=0.490          P=0.754N      |  P=0.314          P=0.494          P=0.480         |
|LOGISTIC REGRESSION|        P=0.578N         P=0.507          P=0.748N      |  (e)              P=0.485          P=0.452         |
|COCH-ARM / FISHERS |        P=0.622          P=0.500          P=0.753N      |  P=0.331          P=0.500          P=0.500         |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 19

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Pigmentation Lipofuscin                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             5.1%             11.0%           |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        2/26 (8%)        4/22 (18%)      |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.019 *        P=0.221          P=0.035 *       |
|POLY 3             |        (e)              (e)              (e)           |  P=0.030 *        P=0.235          P=0.050         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.032 *        P=0.238          P=0.053         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.028 *        P=0.229          P=0.047 *       |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              P=0.221          P=0.035 *       |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.037 *        P=0.247          P=0.059         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        28/50 (56%)      34/50 (68%)      31/49 (63%)   |  35/50 (70%)      40/50 (80%)      32/50 (64%)     |
|POLY-3 ADJUSTED (b)|        61.6%            76.4%            72.0%         |  79.8%            86.8%            77.7%           |
|TERMINAL (d)       |        4/12 (33%)       16/18 (89%)      11/16 (69%)   |  23/28 (82%)      22/26 (85%)      16/22 (73%)     |
|FIRST INCIDENCE    |        509              526              513           |  322              458              507             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.472N         P=0.390          P=0.508N      |  P=0.327          P=0.160          P=0.365         |
|POLY 3             |        P=0.148          P=0.084          P=0.197       |  P=0.475N         P=0.253          P=0.513N        |
|POLY 1.5           |        P=0.171          P=0.109          P=0.216       |  P=0.439N         P=0.213          P=0.476N        |
|POLY 6             |        P=0.130          P=0.059          P=0.184       |  P=0.457N         P=0.309          P=0.501N        |
|LOGISTIC REGRESSION|        P=0.229          P=0.144          P=0.274       |  P=0.454N         P=0.184          P=0.507N        |
|COCH-ARM / FISHERS |        P=0.258          P=0.151          P=0.298       |  P=0.290N         P=0.178          P=0.335N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 20

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       7/50 (14%)       9/49 (18%)    |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        15.3%            17.8%            23.1%         |  2.5%             0.0%             0.0%            |
|TERMINAL (d)       |        2/12 (17%)       2/18 (11%)       2/16 (13%)    |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        509              527              558           |  691              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.332          P=0.567          P=0.406       |  P=0.283N         P=0.507N         P=0.520N        |
|POLY 3             |        P=0.229          P=0.501          P=0.277       |  P=0.284N         P=0.502N         P=0.516N        |
|POLY 1.5           |        P=0.219          P=0.498          P=0.265       |  P=0.280N         P=0.500N         P=0.511N        |
|POLY 6             |        P=0.255          P=0.515          P=0.307       |  P=0.289N         P=0.508N         P=0.522N        |
|LOGISTIC REGRESSION|        P=0.225          P=0.509          P=0.268       |  P=0.278N         P=0.501N         P=0.514N        |
|COCH-ARM / FISHERS |        P=0.227          P=0.500          P=0.274       |  P=0.269N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       9/50 (18%)       5/49 (10%)    |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        20.9%            24.1%            13.4%         |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        5/12 (42%)       7/18 (39%)       3/16 (19%)    |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        646              684              703           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.095N         P=0.430N         P=0.133N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.249N         P=0.475          P=0.287N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.262N         P=0.484          P=0.298N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.221N         P=0.470          P=0.263N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.141N         P=0.543          P=0.186N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.253N         P=0.500          P=0.290N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 21

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       8/50 (16%)       5/49 (10%)    |  2/50 (4%)        3/50 (6%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        13.1%            20.6%            13.1%         |  5.0%             7.6%             5.5%            |
|TERMINAL (d)       |        3/12 (25%)       3/18 (17%)       2/16 (13%)    |  1/28 (4%)        2/26 (8%)        1/22 (5%)       |
|FIRST INCIDENCE    |        654              527              557           |  617              623              693             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.443N         P=0.416          P=0.512N      |  P=0.515          P=0.463          P=0.630         |
|POLY 3             |        P=0.558N         P=0.282          P=0.631N      |  P=0.557          P=0.497          P=0.664         |
|POLY 1.5           |        P=0.546          P=0.277          P=0.617       |  P=0.568          P=0.502          P=0.673         |
|POLY 6             |        P=0.516N         P=0.298          P=0.600N      |  P=0.545          P=0.486          P=0.655         |
|LOGISTIC REGRESSION|        P=0.546          P=0.262          P=0.628       |  P=0.563          P=0.499          P=0.670         |
|COCH-ARM / FISHERS |        P=0.547          P=0.277          P=0.617       |  P=0.594          P=0.500          P=0.691N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        12/12 (100%)     6/8 (75%)        2/6 (33%)     |  4/5 (80%)        1/2 (50%)        3/4 (75%)       |
|POLY-3 ADJUSTED (b)|        100.0%           75.0%            36.5%         |  97.9%            50.0%            84.7%           |
|TERMINAL (d)       |        2/2 (100%)       2/4 (50%)        1/3 (33%)     |  0/0 (0%)         1/2 (50%)        1/1 (100%)      |
|FIRST INCIDENCE    |        509              526              689           |  669              729 (T)          693             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001N**       P=0.051N         P=0.002N**    |  P=0.335N         P=0.076N         P=0.411N        |
|POLY 3             |        P<0.001N**       P=0.134N         P<0.001N**    |  P=0.498N         P=0.360N         P=0.803N        |
|POLY 1.5           |        P<0.001N**       P=0.134N         P<0.001N**    |  P=0.496N         P=0.419N         P=0.717N        |
|POLY 6             |        P=0.002N**       P=0.134N         P<0.001N**    |  P=0.554N         P=0.336N         P=0.984N        |
|LOGISTIC REGRESSION|        P=0.005N**       (e)              P=0.008N**    |  P=0.404N         P=0.292N         (e)             |
|COCH-ARM / FISHERS |        P=0.002N**       P=0.147N         P=0.005N**    |  P=0.568N         P=0.524N         P=0.722N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 22

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/12 (50%)       4/8 (50%)        1/6 (17%)     |  0/5 (0%)         0/2 (0%)         2/4 (50%)       |
|POLY-3 ADJUSTED (b)|        62.1%            50.3%            18.8%         |  0.0%             0.0%             51.8%           |
|TERMINAL (d)       |        2/2 (100%)       1/4 (25%)        1/3 (33%)     |  0/0 (0%)         0/2 (0%)         0/1 (0%)        |
|FIRST INCIDENCE    |        645              526              729 (T)       |  ---              ---              594             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.018N*        P=0.239N         P=0.017N*     |  P=0.084          (e)              P=0.209         |
|POLY 3             |        P=0.096N         P=0.493N         P=0.119N      |  P=0.094          (e)              P=0.218         |
|POLY 1.5           |        P=0.125N         P=0.578N         P=0.152N      |  P=0.079          (e)              P=0.187         |
|POLY 6             |        P=0.066N         P=0.356N         P=0.078N      |  P=0.113          (e)              P=0.261         |
|LOGISTIC REGRESSION|        P=0.134N         P=0.651N         P=0.047N*     |  P=0.062          (e)              P=0.166         |
|COCH-ARM / FISHERS |        P=0.165N         P=0.675N         P=0.199N      |  P=0.072          (e)              P=0.167         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      5/50 (10%)       3/50 (6%)     |  4/50 (8%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        27.5%            13.3%            7.9%          |  9.8%             2.5%             5.4%            |
|TERMINAL (d)       |        4/12 (33%)       3/18 (17%)       2/16 (13%)    |  0/28 (0%)        0/26 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        509              625              719           |  374              634              634             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.005N**       P=0.050N         P=0.010N*     |  P=0.292N         P=0.205N         P=0.407N        |
|POLY 3             |        P=0.012N*        P=0.099N         P=0.021N*     |  P=0.268N         P=0.189N         P=0.387N        |
|POLY 1.5           |        P=0.012N*        P=0.093N         P=0.022N*     |  P=0.258N         P=0.182N         P=0.371N        |
|POLY 6             |        P=0.010N*        P=0.105N         P=0.019N*     |  P=0.279N         P=0.199N         P=0.403N        |
|LOGISTIC REGRESSION|        P=0.010N*        P=0.090N         P=0.020N*     |  P=0.227N         P=0.187N         P=0.326N        |
|COCH-ARM / FISHERS |        P=0.012N*        P=0.086N         P=0.020N*     |  P=0.238N         P=0.181N         P=0.339N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 23

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary: Follicle                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  3/50 (6%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                                                        |  7.5%             2.6%             2.7%            |
|TERMINAL (d)       |                                                        |  2/28 (7%)        1/26 (4%)        1/22 (5%)       |
|FIRST INCIDENCE    |                                                        |  564              729 (T)          729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.255N         P=0.321N         P=0.377N        |
|POLY 3             |                                                        |  P=0.224N         P=0.312N         P=0.338N        |
|POLY 1.5           |                                                        |  P=0.217N         P=0.306N         P=0.327N        |
|POLY 6             |                                                        |  P=0.233N         P=0.323N         P=0.349N        |
|LOGISTIC REGRESSION|                                                        |  P=0.221N         P=0.306N         P=0.328N        |
|COCH-ARM / FISHERS |                                                        |  P=0.202N         P=0.309N         P=0.309N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary: Periovarian Tissue                                                                                                        |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  5/50 (10%)       8/50 (16%)       5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                                                        |  12.5%            19.5%            13.1%           |
|TERMINAL (d)       |                                                        |  2/28 (7%)        5/26 (19%)       2/22 (9%)       |
|FIRST INCIDENCE    |                                                        |  654              403              323             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.442          P=0.243          P=0.527         |
|POLY 3             |                                                        |  P=0.521          P=0.288          P=0.599         |
|POLY 1.5           |                                                        |  P=0.533          P=0.290          P=0.608         |
|POLY 6             |                                                        |  P=0.505          P=0.273          P=0.588         |
|LOGISTIC REGRESSION|                                                        |  P=0.560N         P=0.277          P=0.626         |
|COCH-ARM / FISHERS |                                                        |  P=0.561          P=0.277          P=0.630N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 24

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       5/50 (10%)       11/50 (22%)   |  3/50 (6%)        5/50 (10%)       1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        12.9%            13.0%            28.6%         |  7.6%             12.4%            2.8%            |
|TERMINAL (d)       |        2/12 (17%)       2/18 (11%)       7/16 (44%)    |  2/28 (7%)        3/26 (12%)       1/22 (5%)       |
|FIRST INCIDENCE    |        500              557              684           |  682              518              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.117          P=0.531N         P=0.200       |  P=0.345N         P=0.330          P=0.384N        |
|POLY 3             |        P=0.048 *        P=0.627          P=0.073       |  P=0.309N         P=0.364          P=0.335N        |
|POLY 1.5           |        P=0.048 *        P=0.625          P=0.074       |  P=0.297N         P=0.365          P=0.328N        |
|POLY 6             |        P=0.050          P=0.633N         P=0.079       |  P=0.325N         P=0.356          P=0.345N        |
|LOGISTIC REGRESSION|        P=0.063          P=0.624          P=0.106       |  P=0.291N         P=0.356          P=0.345N        |
|COCH-ARM / FISHERS |        P=0.056          P=0.630N         P=0.086       |  P=0.272N         P=0.357          P=0.316N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        16/47 (34%)      17/45 (38%)      13/47 (28%)   |  1/47 (2%)        0/40 (0%)        2/45 (4%)       |
|POLY-3 ADJUSTED (b)|        40.7%            47.7%            34.3%         |  2.7%             0.0%             6.0%            |
|TERMINAL (d)       |        3/12 (25%)       9/16 (56%)       4/16 (25%)    |  0/26 (0%)        0/21 (0%)        2/21 (10%)      |
|FIRST INCIDENCE    |        565              485              642           |  669              ---              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.154N         P=0.526N         P=0.185N      |  P=0.314          P=0.518N         P=0.436         |
|POLY 3             |        P=0.327N         P=0.347          P=0.363N      |  P=0.346          P=0.538N         P=0.461         |
|POLY 1.5           |        P=0.327N         P=0.389          P=0.362N      |  P=0.347          P=0.535N         P=0.467         |
|POLY 6             |        P=0.319N         P=0.284          P=0.358N      |  P=0.344          P=0.543N         P=0.457         |
|LOGISTIC REGRESSION|        P=0.247N         P=0.380          P=0.296N      |  P=0.334          P=0.533N         P=0.462         |
|COCH-ARM / FISHERS |        P=0.292N         P=0.438          P=0.328N      |  P=0.351          P=0.540N         P=0.484         |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 25

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  8/50 (16%)       5/50 (10%)       3/49 (6%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.7%             0.0%          |  19.4%            12.2%            8.2%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  4/28 (14%)       1/26 (4%)        3/22 (14%)      |
|FIRST INCIDENCE    |        ---              618              ---           |  499              522              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.722          P=0.494          (e)           |  P=0.122N         P=0.307N         P=0.175N        |
|POLY 3             |        P=0.729N         P=0.498          (e)           |  P=0.101N         P=0.273N         P=0.138N        |
|POLY 1.5           |        P=0.728          P=0.498          (e)           |  P=0.090N         P=0.270N         P=0.123N        |
|POLY 6             |        P=0.722N         P=0.501          (e)           |  P=0.115N         P=0.283N         P=0.157N        |
|LOGISTIC REGRESSION|        P=0.722N         P=0.513          (e)           |  P=0.078N         P=0.280N         P=0.117N        |
|COCH-ARM / FISHERS |        P=0.731          P=0.500          (e)           |  P=0.077N         P=0.277N         P=0.106N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)     |  4/50 (8%)        0/50 (0%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.7%             2.6%          |  10.0%            0.0%             5.5%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        1/16 (6%)     |  2/28 (7%)        0/26 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        ---              625              729 (T)       |  527              ---              722             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.357          P=0.494          P=0.557       |  P=0.277N         P=0.070N         P=0.419N        |
|POLY 3             |        P=0.334          P=0.498          P=0.501       |  P=0.240N         P=0.063N         P=0.382N        |
|POLY 1.5           |        P=0.330          P=0.498          P=0.498       |  P=0.234N         P=0.061N         P=0.367N        |
|POLY 6             |        P=0.348          P=0.501          P=0.509       |  P=0.247N         P=0.067N         P=0.398N        |
|LOGISTIC REGRESSION|        P=0.333          P=0.510          P=0.557       |  P=0.241N         P=0.063N         P=0.367N        |
|COCH-ARM / FISHERS |        P=0.331          P=0.500          P=0.500       |  P=0.228N         P=0.059N         P=0.349N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 26

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  1/50 (2%)        2/50 (4%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.5%             5.1%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        2/26 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  682              729 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.416N         P=0.472          P=0.526N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.395N         P=0.496          P=0.516N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.383N         P=0.501          P=0.511N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.409N         P=0.486          P=0.522N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.388N         P=0.487          P=0.512N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.366N         P=0.500          P=0.505N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  1/50 (2%)        2/50 (4%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.5%             5.1%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  1/28 (4%)        2/26 (8%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  729 (T)          729 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.424N         P=0.474          P=0.548N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.393N         P=0.498          P=0.515N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.382N         P=0.501          P=0.511N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.404N         P=0.489          P=0.520N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.424N         P=0.474          (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.366N         P=0.500          P=0.505N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 27

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        49/50 (98%)      46/50 (92%)      43/50 (86%)   |                                                    |
|POLY-3 ADJUSTED (b)|        98.4%            94.4%            90.2%         |                                                    |
|TERMINAL (d)       |        12/12 (100%)     18/18 (100%)     15/16 (94%)   |                                                    |
|FIRST INCIDENCE    |        500              430              106           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.073N         P=0.179N         P=0.074N      |                                                    |
|POLY 3             |        P=0.034N*        P=0.268N         P=0.058N      |                                                    |
|POLY 1.5           |        P=0.026N*        P=0.220N         P=0.042N*     |                                                    |
|POLY 6             |        P=0.057N         P=0.390N         P=0.109N      |                                                    |
|LOGISTIC REGRESSION|        P=0.023N*        P=0.183N         P=0.034N*     |                                                    |
|COCH-ARM / FISHERS |        P=0.021N*        P=0.181N         P=0.030N*     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/50 (14%)       5/50 (10%)       3/49 (6%)     |                                                    |
|POLY-3 ADJUSTED (b)|        17.8%            13.2%            7.9%          |                                                    |
|TERMINAL (d)       |        1/12 (8%)        3/18 (17%)       0/16 (0%)     |                                                    |
|FIRST INCIDENCE    |        583              578              684           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.086N         P=0.299N         P=0.118N      |                                                    |
|POLY 3             |        P=0.129N         P=0.403N         P=0.168N      |                                                    |
|POLY 1.5           |        P=0.134N         P=0.394N         P=0.174N      |                                                    |
|POLY 6             |        P=0.119N         P=0.413N         P=0.157N      |                                                    |
|LOGISTIC REGRESSION|        P=0.124N         P=0.389N         P=0.164N      |                                                    |
|COCH-ARM / FISHERS |        P=0.128N         P=0.380N         P=0.167N      |                                                    |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 28

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        2/49 (4%)     |                                                    |
|POLY-3 ADJUSTED (b)|        2.6%             2.7%             5.3%          |                                                    |
|TERMINAL (d)       |        1/12 (8%)        1/18 (6%)        0/16 (0%)     |                                                    |
|FIRST INCIDENCE    |        729 (T)          729 (T)          583           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.454          P=0.670N         P=0.585       |                                                    |
|POLY 3             |        P=0.378          P=0.757          P=0.499       |                                                    |
|POLY 1.5           |        P=0.371          P=0.758          P=0.491       |                                                    |
|POLY 6             |        P=0.395          P=0.759          P=0.517       |                                                    |
|LOGISTIC REGRESSION|        P=0.382          P=0.670N         P=0.494       |                                                    |
|COCH-ARM / FISHERS |        P=0.372          P=0.753N         P=0.492       |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis, Skin, Site of Application                                                                                       |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        29/50 (58%)      44/50 (88%)   |  5/50 (10%)       33/50 (66%)      44/50 (88%)     |
|POLY-3 ADJUSTED (b)|        0.0%             67.0%            90.9%         |  12.4%            69.2%            91.7%           |
|TERMINAL (d)       |        0/12 (0%)        13/18 (72%)      14/16 (88%)   |  3/28 (11%)       15/26 (58%)      20/22 (91%)     |
|FIRST INCIDENCE    |        ---              500              106           |  471              238              323             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 29

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Sebaceous Gland, Skin, Site of Application                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        27/50 (54%)      44/50 (88%)   |  3/50 (6%)        41/50 (82%)      45/50 (90%)     |
|POLY-3 ADJUSTED (b)|        0.0%             65.2%            91.0%         |  7.5%             84.0%            95.1%           |
|TERMINAL (d)       |        0/12 (0%)        14/18 (78%)      14/16 (88%)   |  2/28 (7%)        22/26 (85%)      21/22 (96%)     |
|FIRST INCIDENCE    |        ---              500              106           |  471              238              323             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        23/50 (46%)      25/50 (50%)   |  0/50 (0%)        20/50 (40%)      29/50 (58%)     |
|POLY-3 ADJUSTED (b)|        0.0%             55.3%            57.7%         |  0.0%             44.8%            64.3%           |
|TERMINAL (d)       |        0/12 (0%)        8/18 (44%)       10/16 (63%)   |  0/28 (0%)        4/26 (15%)       10/22 (46%)     |
|FIRST INCIDENCE    |        ---              430              106           |  ---              518              323             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 30

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        10/50 (20%)      28/50 (56%)   |  3/50 (6%)        35/50 (70%)      34/50 (68%)     |
|POLY-3 ADJUSTED (b)|        0.0%             25.6%            63.1%         |  7.5%             74.8%            76.1%           |
|TERMINAL (d)       |        0/12 (0%)        3/18 (17%)       9/16 (56%)    |  2/28 (7%)        18/26 (69%)      15/22 (68%)     |
|FIRST INCIDENCE    |        ---              526              106           |  471              403              323             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P=0.003 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Parakeratosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        21/50 (42%)      33/50 (66%)   |  2/50 (4%)        12/50 (24%)      25/50 (50%)     |
|POLY-3 ADJUSTED (b)|        0.0%             49.3%            71.8%         |  5.0%             28.2%            54.7%           |
|TERMINAL (d)       |        0/12 (0%)        7/18 (39%)       10/16 (63%)   |  1/28 (4%)        4/26 (15%)       4/22 (18%)      |
|FIRST INCIDENCE    |        ---              430              106           |  471              518              323             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.007 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.004 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.004 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.005 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.004 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.004 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 31

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Skin, Site of Application                                                                                                  |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        4/50 (8%)        25/50 (50%)   |  3/50 (6%)        2/50 (4%)        10/50 (20%)     |
|POLY-3 ADJUSTED (b)|        0.0%             10.4%            56.2%         |  7.5%             5.1%             25.2%           |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        7/16 (44%)    |  2/28 (7%)        1/26 (4%)        4/22 (18%)      |
|FIRST INCIDENCE    |        ---              544              106           |  471              696              427             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P=0.060          P<0.001 **    |  P=0.009 **       P=0.515N         P=0.023 *       |
|POLY 3             |        P<0.001 **       P=0.061          P<0.001 **    |  P=0.012 *        P=0.510N         P=0.030 *       |
|POLY 1.5           |        P<0.001 **       P=0.060          P<0.001 **    |  P=0.012 *        P=0.503N         P=0.030 *       |
|POLY 6             |        P<0.001 **       P=0.064          P<0.001 **    |  P=0.012 *        P=0.523N         P=0.031 *       |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.066          P<0.001 **    |  P=0.015 *        P=0.499N         P=0.039 *       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.059          P<0.001 **    |  P=0.015 *        P=0.500N         P=0.036 *       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       5/50 (10%)       5/50 (10%)    |  1/50 (2%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        20.7%            13.1%            13.0%         |  2.5%             2.5%             2.7%            |
|TERMINAL (d)       |        5/12 (42%)       1/18 (6%)        4/16 (25%)    |  1/28 (4%)        0/26 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        506              625              603           |  729 (T)          575              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.130N         P=0.176N         P=0.136N      |  P=0.595          P=0.760          P=0.708         |
|POLY 3             |        P=0.216N         P=0.278N         P=0.272N      |  P=0.624          P=0.760N         P=0.744         |
|POLY 1.5           |        P=0.227N         P=0.281N         P=0.284N      |  P=0.628          P=0.758N         P=0.749         |
|POLY 6             |        P=0.195N         P=0.261N         P=0.245N      |  P=0.620          P=0.759          P=0.739         |
|LOGISTIC REGRESSION|        P=0.200N         P=0.285N         P=0.235N      |  P=0.627          P=0.762          P=0.708         |
|COCH-ARM / FISHERS |        P=0.221N         P=0.277N         P=0.277N      |  P=0.640          P=0.753N         P=0.753N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 32

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        3/50 (6%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        7.6%             7.9%             7.8%          |  0.0%             0.0%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        1/16 (6%)     |  0/28 (0%)        0/26 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        500              578              696           |  ---              ---              729 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.533N         P=0.646          P=0.603N      |  P=0.237          (e)              P=0.452         |
|POLY 3             |        P=0.572          P=0.650          P=0.652       |  P=0.273          (e)              P=0.485         |
|POLY 1.5           |        P=0.570          P=0.653          P=0.650       |  P=0.272          (e)              P=0.489         |
|POLY 6             |        P=0.580          P=0.650          P=0.661       |  P=0.274          (e)              P=0.480         |
|LOGISTIC REGRESSION|        P=0.576N         P=0.621N         P=0.660N      |  (e)              (e)              P=0.452         |
|COCH-ARM / FISHERS |        P=0.583          P=0.661N         P=0.661N      |  P=0.269          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  3/50 (6%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  7.5%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  1/28 (4%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  527              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.046N*        P=0.128N         P=0.150N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.039N*        P=0.123N         P=0.136N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.038N*        P=0.120N         P=0.130N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.041N*        P=0.129N         P=0.143N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.037N*        P=0.121N         P=0.122N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.037N*        P=0.121N         P=0.121N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 33

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Edema                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.2%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              703           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.118          (e)              P=0.278       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.095          (e)              P=0.239       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.094          (e)              P=0.235       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.099          (e)              P=0.249       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.104          (e)              P=0.253       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.095          (e)              P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.6%             5.4%             2.6%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        2/18 (11%)       0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        670              729 (T)          703           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.556N         P=0.580          P=0.728N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.620N         P=0.491          P=0.761N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.617          P=0.494          P=0.758       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.608N         P=0.490          P=0.753N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.590N         P=0.505          P=0.758N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.622          P=0.500          P=0.753N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 34

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.6%             5.4%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        2/18 (11%)       0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        589              729 (T)          ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.310N         P=0.591          P=0.500N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.363N         P=0.489          P=0.501N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.368N         P=0.493          P=0.503N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.351N         P=0.486          P=0.495N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.356N         P=0.494          P=0.469N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.360N         P=0.500          P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        10/50 (20%)      6/50 (12%)       7/50 (14%)    |  0/50 (0%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        24.1%            15.4%            17.8%         |  0.0%             5.0%             5.4%            |
|TERMINAL (d)       |        0/12 (0%)        2/18 (11%)       2/16 (13%)    |  0/28 (0%)        0/26 (0%)        1/22 (5%)       |
|FIRST INCIDENCE    |        506              485              522           |  ---              575              594             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.207N         P=0.221N         P=0.246N      |  P=0.159          P=0.245          P=0.208         |
|POLY 3             |        P=0.271N         P=0.239N         P=0.334N      |  P=0.161          P=0.241          P=0.222         |
|POLY 1.5           |        P=0.267N         P=0.225N         P=0.328N      |  P=0.165          P=0.241          P=0.226         |
|POLY 6             |        P=0.272N         P=0.258N         P=0.336N      |  P=0.158          P=0.239          P=0.219         |
|LOGISTIC REGRESSION|        P=0.229N         P=0.173N         P=0.286N      |  P=0.184          P=0.225          P=0.230         |
|COCH-ARM / FISHERS |        P=0.244N         P=0.207N         P=0.298N      |  P=0.176          P=0.247          P=0.247         |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 35

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      5/50 (10%)       3/50 (6%)     |  2/50 (4%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        26.4%            12.6%            7.8%          |  5.0%             5.0%             2.7%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        1/16 (6%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        506              527              689           |  669              534              594             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.014N*        P=0.116N         P=0.021N*     |  P=0.420N         P=0.687          P=0.538N        |
|POLY 3             |        P=0.014N*        P=0.097N         P=0.026N*     |  P=0.423N         P=0.690N         P=0.526N        |
|POLY 1.5           |        P=0.013N*        P=0.092N         P=0.025N*     |  P=0.414N         P=0.689N         P=0.518N        |
|POLY 6             |        P=0.015N*        P=0.102N         P=0.028N*     |  P=0.433N         P=0.694          P=0.533N        |
|LOGISTIC REGRESSION|        P=0.009N**       P=0.057N         P=0.020N*     |  P=0.374N         P=0.690          P=0.509N        |
|COCH-ARM / FISHERS |        P=0.012N*        P=0.086N         P=0.020N*     |  P=0.390N         P=0.691N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)     |  3/50 (6%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             0.0%          |  7.3%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        680              ---              ---           |  322              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.255N         P=0.517N         P=0.470N      |  P=0.041N*        P=0.120N         P=0.136N        |
|POLY 3             |        P=0.270N         P=0.505N         P=0.500N      |  P=0.041N*        P=0.127N         P=0.141N        |
|POLY 1.5           |        P=0.272N         P=0.503N         P=0.503N      |  P=0.039N*        P=0.122N         P=0.135N        |
|POLY 6             |        P=0.270N         P=0.506N         P=0.493N      |  P=0.043N*        P=0.134N         P=0.148N        |
|LOGISTIC REGRESSION|        P=0.268N         P=0.503N         P=0.498N      |  P=0.026N*        P=0.136N         P=0.089N        |
|COCH-ARM / FISHERS |        P=0.269N         P=0.500N         P=0.500N      |  P=0.038N*        P=0.121N         P=0.125N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 36

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        3/50 (6%)     |  0/50 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             7.9%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        1/16 (6%)     |  0/28 (0%)        0/26 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        618              ---              717           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.234          P=0.506N         P=0.412       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.174          P=0.506N         P=0.304       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.173          P=0.504N         P=0.300       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.178          P=0.507N         P=0.315       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.187          P=0.487N         P=0.321       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.176          P=0.500N         P=0.309       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        15/50 (30%)      16/50 (32%)      17/50 (34%)   |                                                    |
|POLY-3 ADJUSTED (b)|        36.7%            40.6%            43.5%         |                                                    |
|TERMINAL (d)       |        3/12 (25%)       10/18 (56%)      9/16 (56%)    |                                                    |
|FIRST INCIDENCE    |        563              485              555           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.446N         P=0.459N         P=0.476N      |                                                    |
|POLY 3             |        P=0.299          P=0.445          P=0.342       |                                                    |
|POLY 1.5           |        P=0.320          P=0.471          P=0.360       |                                                    |
|POLY 6             |        P=0.272          P=0.403          P=0.318       |                                                    |
|LOGISTIC REGRESSION|        P=0.409          P=0.472          P=0.461       |                                                    |
|COCH-ARM / FISHERS |        P=0.374          P=0.500          P=0.415       |                                                    |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 37

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        5/50 (10%)    |                                                    |
|POLY-3 ADJUSTED (b)|        5.2%             10.7%            13.0%         |                                                    |
|TERMINAL (d)       |        0/12 (0%)        3/18 (17%)       2/16 (13%)    |                                                    |
|FIRST INCIDENCE    |        634              663              695           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.249          P=0.410          P=0.309       |                                                    |
|POLY 3             |        P=0.165          P=0.322          P=0.212       |                                                    |
|POLY 1.5           |        P=0.162          P=0.328          P=0.209       |                                                    |
|POLY 6             |        P=0.175          P=0.318          P=0.223       |                                                    |
|LOGISTIC REGRESSION|        P=0.196          P=0.329          P=0.238       |                                                    |
|COCH-ARM / FISHERS |        P=0.169          P=0.339          P=0.218       |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        6/50 (12%)       7/50 (14%)    |                                                    |
|POLY-3 ADJUSTED (b)|        10.5%            16.0%            17.9%         |                                                    |
|TERMINAL (d)       |        2/12 (17%)       4/18 (22%)       3/16 (19%)    |                                                    |
|FIRST INCIDENCE    |        654              626              603           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.331          P=0.522          P=0.395       |                                                    |
|POLY 3             |        P=0.222          P=0.356          P=0.269       |                                                    |
|POLY 1.5           |        P=0.211          P=0.361          P=0.257       |                                                    |
|POLY 6             |        P=0.250          P=0.358          P=0.298       |                                                    |
|LOGISTIC REGRESSION|        P=0.247          P=0.367          P=0.288       |                                                    |
|COCH-ARM / FISHERS |        P=0.215          P=0.370          P=0.262       |                                                    |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 38

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        4/50 (8%)     |                                                    |
|POLY-3 ADJUSTED (b)|        7.8%             5.2%             10.4%         |                                                    |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        3/16 (19%)    |                                                    |
|FIRST INCIDENCE    |        563              544              642           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.476          P=0.522N         P=0.587       |                                                    |
|POLY 3             |        P=0.414          P=0.505N         P=0.497       |                                                    |
|POLY 1.5           |        P=0.410          P=0.504N         P=0.491       |                                                    |
|POLY 6             |        P=0.427          P=0.503N         P=0.514       |                                                    |
|LOGISTIC REGRESSION|        P=0.414          P=0.472N         P=0.510       |                                                    |
|COCH-ARM / FISHERS |        P=0.417          P=0.500N         P=0.500       |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/44 (16%)       0/50 (0%)        0/47 (0%)     |  2/44 (5%)        1/49 (2%)        0/48 (0%)       |
|POLY-3 ADJUSTED (b)|        20.0%            0.0%             0.0%          |  5.6%             2.6%             0.0%            |
|TERMINAL (d)       |        0/11 (0%)        0/18 (0%)        0/15 (0%)     |  0/24 (0%)        0/25 (0%)        0/22 (0%)       |
|FIRST INCIDENCE    |        626              ---              ---           |  499              582              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001N**       P=0.012N*        P=0.007N**    |  P=0.153N         P=0.497N         P=0.259N        |
|POLY 3             |        P<0.001N**       P=0.005N**       P=0.006N**    |  P=0.144N         P=0.470N         P=0.238N        |
|POLY 1.5           |        P<0.001N**       P=0.005N**       P=0.006N**    |  P=0.138N         P=0.465N         P=0.232N        |
|POLY 6             |        P<0.001N**       P=0.005N**       P=0.006N**    |  P=0.150N         P=0.480N         P=0.245N        |
|LOGISTIC REGRESSION|        P<0.001N**       P=0.006N**       P=0.007N**    |  P=0.108N         P=0.474N         P=0.197N        |
|COCH-ARM / FISHERS |        P<0.001N**       P=0.004N**       P=0.005N**    |  P=0.126N         P=0.459N         P=0.226N        |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 39

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        0/50 (0%)        3/50 (6%)     |  2/50 (4%)        5/50 (10%)       3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        7.8%             0.0%             7.9%          |  5.1%             12.5%            8.2%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        3/16 (19%)    |  2/28 (7%)        2/26 (8%)        2/22 (9%)       |
|FIRST INCIDENCE    |        646              ---              729 (T)       |  729 (T)          623              724             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.529N         P=0.134N         P=0.572N      |  P=0.325          P=0.189          P=0.399         |
|POLY 3             |        P=0.600          P=0.124N         P=0.660       |  P=0.374          P=0.220          P=0.465         |
|POLY 1.5           |        P=0.599          P=0.122N         P=0.655       |  P=0.388          P=0.221          P=0.475         |
|POLY 6             |        P=0.600N         P=0.125N         P=0.660N      |  P=0.360          P=0.217          P=0.454         |
|LOGISTIC REGRESSION|        P=0.572N         P=0.123N         P=0.632N      |  P=0.372          P=0.211          P=0.431         |
|COCH-ARM / FISHERS |        P=0.601          P=0.121N         P=0.661N      |  P=0.421          P=0.218          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicle                                                                                                          |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        10.4%            0.0%             5.2%          |  0.0%             2.6%             0.0%            |
|TERMINAL (d)       |        2/12 (17%)       0/18 (0%)        1/16 (6%)     |  0/28 (0%)        1/26 (4%)        0/22 (0%)       |
|FIRST INCIDENCE    |        634              ---              695           |  ---              729 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.170N         P=0.047N*        P=0.256N      |  P=0.699          P=0.485          (e)             |
|POLY 3             |        P=0.219N         P=0.063N         P=0.337N      |  P=0.717          P=0.499          (e)             |
|POLY 1.5           |        P=0.223N         P=0.062N         P=0.344N      |  P=0.721          P=0.501          (e)             |
|POLY 6             |        P=0.214N         P=0.063N         P=0.322N      |  P=0.713          P=0.494          (e)             |
|LOGISTIC REGRESSION|        P=0.204N         P=0.064N         P=0.310N      |  (e)              P=0.485          (e)             |
|COCH-ARM / FISHERS |        P=0.222N         P=0.059N         P=0.339N      |  P=0.731          P=0.500          (e)             |
|=================================================================================================================================|
       Date:  07/28/97                           EXPERIMENT: 55323 TEST: 03                                            Page 40

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -   LAURIC ACID DIETHANOLAMINE CONDENSATE
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/49 (0%)        3/49 (6%)        0/47 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             7.7%             0.0%            |
|TERMINAL (d)       |        0/12 (0%)        0/18 (0%)        0/16 (0%)     |  0/27 (0%)        3/26 (12%)       0/22 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              729 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.586          P=0.113          (e)             |
|POLY 3             |        (e)              (e)              (e)           |  P=0.606          P=0.119          (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.612          P=0.120          (e)             |
|POLY 6             |        (e)              (e)              (e)           |  P=0.599          P=0.116          (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              P=0.113          (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.629          P=0.121          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        0 MG/KG          50 MG/KG         100           |  0 MG/KG          50 MG/KG         100             |
|                   |                                          MG/KG         |                                    MG/KG           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  4/50 (8%)        4/50 (8%)        8/50 (16%)      |
|POLY-3 ADJUSTED (b)|                                                        |  9.9%             10.0%            20.3%           |
|TERMINAL (d)       |                                                        |  2/28 (7%)        1/26 (4%)        3/22 (14%)      |
|FIRST INCIDENCE    |                                                        |  479              594              36              |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.093          P=0.613          P=0.127         |
|POLY 3             |                                                        |  P=0.117          P=0.641          P=0.162         |
|POLY 1.5           |                                                        |  P=0.121          P=0.643N         P=0.168         |
|POLY 6             |                                                        |  P=0.114          P=0.631          P=0.158         |
|LOGISTIC REGRESSION|                                                        |  P=0.150          P=0.643N         P=0.210         |
|COCH-ARM / FISHERS |                                                        |  P=0.128          P=0.643N         P=0.178         |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).