Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/5668

TDMS Study 55323-04 Pathology Tables

NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97
Route: SKIN APPLICATION                                                                                           Time: 07:31:35

                                                         2 YEAR CHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-40-1

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      4            2            5                                                  
    Moribund Sacrifice                                 9            7           15                                                  
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           40           29                                                  
  Missing                                                           1                                                               

  Animals Examined Microscopically                    50           49           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (49)         (50)                                                
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (49)         (50)                                                
   Liver                                              (50)         (49)         (50)                                                
      Hemangiosarcoma                                  2 (4%)       1 (2%)                                                          
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                         7 (14%)     10 (20%)     14 (28%)                                            
      Hepatocellular Carcinoma, Multiple               3 (6%)       3 (6%)       2 (4%)                                             
      Hepatocellular Adenoma                          11 (22%)     18 (37%)     14 (28%)                                            
      Hepatocellular Adenoma, Multiple                12 (24%)     15 (31%)     15 (30%)                                            
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
   Mesentery                                          (7)          (10)         (4)                                                 
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (25%)                                            
   Pancreas                                           (50)         (49)         (50)                                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
   Salivary Glands                                    (50)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (50)                                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (50)                                                
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)                    2 (4%)                                             
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (47)         (49)         (50)                                                
      Pars Distalis, Adenoma                           9 (19%)      9 (18%)      7 (14%)                                            
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (50)                                                
      Follicular Cell, Adenoma                         4 (8%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)         (50)                                                
      Cystadenoma                                      4 (8%)       1 (2%)       2 (4%)                                             
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
      Granulosa Cell Tumor Benign                                   2 (4%)       1 (2%)                                             
      Granulosa-Theca Tumor Malignant                  1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Bilateral, Granulosa Cell Tumor Benign           1 (2%)                                                                       
   Uterus                                             (50)         (49)         (50)                                                
      Deciduoma Benign                                              1 (2%)                                                          
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                       1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Polyp Stromal                                    2 (4%)       1 (2%)                                                          
      Schwannoma Malignant                                          1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (5)          (4)          (7)                                                 
      Lumbar, Fibrous Histiocytoma                     1 (20%)                                                                      
      Lumbar, Histiocytic Sarcoma                                                1 (14%)                                            
      Mediastinal, Fibrous Histiocytoma                1 (20%)                                                                      

                                                             Page   3                                                               
NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Pheochromocytoma Malignant,                                                                                      
           Metastatic, Adrenal Medulla                                           1 (14%)                                            
      Popliteal, Fibrous Histiocytoma                  1 (20%)                                                                      
      Renal, Fibrous Histiocytoma                      1 (20%)                                                                      
      Renal, Hemangiosarcoma                                        1 (25%)                                                         
   Lymph Node, Mandibular                             (46)         (48)         (48)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (48)         (47)                                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (50)         (49)         (50)                                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangiosarcoma                                  2 (4%)                    1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (50)         (47)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)         (50)                                                
      Carcinoma                                        1 (2%)                                                                       
   Skin                                               (50)         (49)         (50)                                                
      Subcutaneous Tissue, Fibrosarcoma                                          2 (4%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibrosarcoma                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Rhabdomyosarcoma                                              1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (4%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   7 (14%)      3 (6%)       3 (6%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       1 (2%)                                                          
      Granular Cell Tumor Malignant, Metastatic,                                                                                    
           Ovary                                                    1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       2 (4%)       2 (4%)                                             
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
      Mediastinum, Hemangiosarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (1)          (1)                                                 
      Adenoma                                          1 (50%)                                                                      
      Carcinoma                                        1 (50%)      1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
   Urinary Bladder                                    (50)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(49)        *(50)                                                
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Lymphoma Malignant                               9 (18%)      5 (10%)      9 (18%)                                            
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          43          45                                                   
     Total Primary Neoplasms                           90          82          85                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          37          35                                                   
     Total Benign Neoplasms                            50          53          44                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          22          31                                                   
     Total Malignant Neoplasms                         40          29          41                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           4           3                                                   
     Total Metastatic Neoplasm                          6           4           7                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            6            7                                                  
    Natural Death                                      3            7            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           37           41                                                  

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (47)         (49)         (49)                                                
   Intestine Small, Duodenum                          (50)         (50)         (49)                                                
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)                                                
      Epithelium, Carcinoma                                         1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Carcinoid Tumor Malignant, Metastatic,                                                                                        
          Stomach, Forestomach                                                   1 (2%)                                             
      Carcinoid Tumor Malignant, Metastatic,                                                                                        
          Stomach, Glandular                                        1 (2%)                                                          
      Carcinoma, Metastatic, Islets, Pancreatic        1 (2%)                                                                       
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Hemangiosarcoma                                  7 (14%)      2 (4%)       3 (6%)                                             
      Hepatocellular Carcinoma                         8 (16%)      8 (16%)     11 (22%)                                            
      Hepatocellular Carcinoma, Multiple               3 (6%)                    1 (2%)                                             
      Hepatocellular Adenoma                          13 (26%)     22 (44%)     15 (30%)                                            
      Hepatocellular Adenoma, Multiple                 6 (12%)      4 (8%)      10 (20%)                                            
      Hepatocholangiocarcinoma                                      1 (2%)                                                          
   Pancreas                                           (50)         (50)         (50)                                                
      Acinus, Hepatocholangiocarcinoma, Metastatic,                                                                                 
           Liver                                                    1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)                                                
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Carcinoid Tumor Malignant                                     1 (2%)                                                          
      Serosa, Carcinoid Tumor Malignant,                                                                                            
          Metastatic, Stomach, Glandular                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)       4 (8%)                                                          
      Capsule, Adenoma                                 1 (2%)       3 (6%)       1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (49)                                                
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                                       2 (4%)       1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (48)         (49)         (50)                                                
      Pars Distalis, Adenoma                                        1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Follicular Cell, Adenoma                         1 (2%)       4 (8%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
   Prostate                                           (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (3)          (2)          (1)                                                 
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (33%)                                                                      
      Mediastinal, Carcinoma, Metastatic, Mammary                                                                                   
          Gland                                                                  1 (100%)                                           

                                                             Page   8                                                               
NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (46)         (45)         (46)                                                
   Lymph Node, Mesenteric                             (49)         (49)         (50)                                                
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                  2 (4%)                    2 (4%)                                             
   Thymus                                             (45)         (45)         (49)                                                
      Hemangioma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (5)                       (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     5 (10%)      5 (10%)      9 (18%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   6 (12%)      8 (16%)      6 (12%)                                            
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)                                                                       
      Carcinoma, Metastatic, Islets, Pancreatic        1 (2%)                                                                       
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Hemangiosarcoma, Metastatic, Liver               1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       2 (4%)       4 (8%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Bronchiole, Adenoma                              1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (2)          (3)                                                 
      Adenoma                                          1 (100%)     2 (100%)     3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Renal Tubule, Adenoma                                         1 (2%)       1 (2%)                                             
   Ureter                                             (1)                                                                           
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant                               4 (8%)       3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 55323-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                               LAURIC ACID DIETHANOLAMINE CONDENSATE                           Date: 07/30/97  
Route: SKIN APPLICATION                                                                                           Time: 07:31:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      100          200                                                    
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          44          42                                                   
     Total Primary Neoplasms                           67          76          69                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27          36          35                                                   
     Total Benign Neoplasms                            32          51          43                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          23          22                                                   
     Total Malignant Neoplasms                         35          25          26                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           5           6                                                   
     Total Metastatic Neoplasm                          8           6          13                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------