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TDMS Study 56111-03 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                                TRANS-CINNAMALDEHYDE                                          DATE: 07/02/01  
EXPERIMENT: 56111 TEST: 03                                                                                        TIME: 09:43:58    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C56111B     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS LABORATORY                     TRANS-CINNAMALDEHYDE                                        DATE: 07/02/01    
EXPERIMENT: 56111 TEST: 03                                                                                        TIME:  9:52:42    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  56111B      
CONT: N01-ES-55384                                                                                                CAS: 14371-10-9   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                         
                                            CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                        
==================================================================================================================================  
      UNTREATDCONTROL             VEHICLE CONTROL                         .312%                              .625%                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    17.2    97.7      17.3     97.3    1.01        0     16.6     97.8    0.97      531     15.5     97.6    0.90      994       
  2    17.3   133.8      17.6    134.1    1.02        0     16.9    132.2    0.98      398     16.2    128.9    0.94      785       
  6    19.7   252.7      20.0    255.0    1.02        0     19.7    251.7    1.00      244     19.5    244.1    0.99      499       
 10    16.7   306.7      16.2    307.9    0.97        0     16.4    303.8    0.98      169     16.4    293.9    0.98      348       
 14    17.4   343.3      17.7    349.9    1.02        0     17.2    341.8    0.99      157     16.5    329.0    0.95      314       
 18    17.0   374.2      17.0    377.6    1.00        0     15.9    368.1    0.94      135     16.0    358.0    0.94      279       
 22    18.2   393.1      18.3    396.7    1.01        0     17.6    381.7    0.97      144     17.6    375.1    0.97      293       
 26    18.9   403.5      20.2    409.9    1.07        0     19.3    396.5    1.02      152     18.0    387.4    0.95      291       
 30    19.6   420.5      19.1    423.9    0.97        0     18.5    413.2    0.94      140     19.4    403.9    0.99      300       
 34    19.2   439.2      19.3    443.8    1.01        0     18.4    430.0    0.96      134     18.8    419.6    0.98      280       
 38    19.4   444.5      19.1    448.1    0.98        0     19.2    438.0    0.99      137     18.3    428.5    0.94      267       
 42    18.1   458.4      18.1    463.1    1.00        0     17.4    449.4    0.96      121     18.3    439.7    1.01      260       
 46    18.5   465.6      18.7    468.4    1.01        0     18.2    455.9    0.98      125     18.5    446.4    1.00      259       
 50    18.4   467.5      19.8    474.8    1.08        0     18.7    461.6    1.02      126     18.4    452.5    1.00      254       
 54    18.0   473.8      17.9    484.0    0.99        0     17.3    467.8    0.96      115     17.8    458.2    0.99      243       
 58    16.8   477.9      17.1    481.5    1.02        0     15.8    468.3    0.94      105     16.2    463.3    0.96      219       
 62    16.0   472.2      16.9    476.1    1.06        0     16.4    465.5    1.03      110     16.6    457.4    1.04      226       
 66    18.0   479.2      18.5    488.7    1.03        0     18.3    471.3    1.02      121     17.6    461.3    0.98      238       
 70    17.1   478.1      17.0    480.2    0.99        0     16.9    471.8    0.99      111     17.2    463.7    1.01      232       
 74    17.9   482.7      17.8    485.0    0.99        0     18.4    475.2    1.03      121     17.9    468.0    1.00      240       
 78    18.1   482.4      18.2    486.3    1.01        0     18.4    476.3    1.02      121     18.0    468.7    0.99      240       
 82    17.7   485.1      17.3    490.9    0.98        0     16.4    475.6    0.93      108     17.0    469.5    0.96      226       
 86    17.8   478.0      16.9    486.8    0.95        0     16.6    474.4    0.93      109     17.3    466.6    0.97      231       
 90    17.4   480.0      17.7    492.1    1.02        0     17.0    474.6    0.98      112     16.6    460.2    0.95      225       
 94    17.3   476.7      16.6    484.6    0.96        0     16.3    475.4    0.94      107     16.3    461.4    0.94      221       
 98    15.8   479.8      17.0    488.3    1.08        0     14.8    465.6    0.94       99     14.9    451.2    0.94      206       
102    16.0   469.8      17.5    486.9    1.09        0     16.2    467.3    1.01      108     15.0    443.0    0.94      211       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   17.7   197.7      17.8    198.6    1.00        0     17.4    196.4    0.98      335     16.9    191.1    0.95      657       
SD(D)   1.3               1.6             0.02        0      1.5             0.01      161      1.8             0.04      289       
CV(E)   7.5               8.9             2.2                8.7             1.5      48.2     10.5             4.4      44.0       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   18.5   421.0      18.7    425.6    1.01        0     18.0    413.6    0.98      137     18.0    404.0    0.97      280       
SD(D)   0.8               1.0             0.03        0      1.0             0.03       12      1.0             0.03       20       
CV(E)   4.5               5.2             3.3                5.6             2.9       8.5      5.7             2.7       7.1       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   17.2   478.1      17.4    485.5    1.01        0     16.8    471.5    0.98      111     16.8    461.0    0.98      228       
SD(D)   0.8               0.6             0.04        0      1.1             0.04        7      1.0             0.03       11       
CV(E)   4.8               3.3             4.2                6.3             4.0       5.9      6.0             3.0       4.9       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                                                   
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                                                                    
==========================================                                                                                          
                     1.25%                                                                                                          
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       FEED/   WEIGHT  FEED (B)    DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  1    12.6     97.9     0.73    1607                                                                                               
  2    15.4    121.6     0.89    1585                                                                                               
  6    18.7    236.6     0.95     989                                                                                               
 10    16.3    283.7     0.98     718                                                                                               
 14    16.9    320.1     0.97     661                                                                                               
 18    15.0    345.2     0.88     544                                                                                               
 22    17.1    360.5     0.94     592                                                                                               
 26    18.2    372.8     0.96     610                                                                                               
 30    17.4    388.4     0.89     561                                                                                               
 34    18.5    403.6     0.96     572                                                                                               
 38    18.4    410.6     0.95     560                                                                                               
 42    16.3    420.5     0.90     485                                                                                               
 46    18.0    426.7     0.97     528                                                                                               
 50    17.7    433.2     0.96     510                                                                                               
 54    17.1    437.9     0.95     487                                                                                               
 58    15.6    441.2     0.93     441                                                                                               
 62    16.0    438.2     1.00     457                                                                                               
 66    17.3    444.8     0.96     486                                                                                               
 70    15.6    442.2     0.91     440                                                                                               
 74    17.9    444.6     1.00     504                                                                                               
 78    17.4    444.3     0.96     489                                                                                               
 82    16.1    448.2     0.91     450                                                                                               
 86    16.6    445.0     0.93     466                                                                                               
 90    15.9    440.4     0.91     450                                                                                               
 94    14.8    443.5     0.86     417                                                                                               
 98    15.6    439.2     0.99     444                                                                                               
102    15.7    434.8     0.98     451                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   15.8    184.9     0.89    1225                                                                                               
SD(D)   2.5              0.11     443                                                                                               
CV(E)  16.1             12.3     36.2                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   17.4    388.2     0.94     562                                                                                               
SD(D)   1.1              0.04      51                                                                                               
CV(E)   6.2              3.8      9.0                                                                                               
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   16.3    441.9     0.95     460                                                                                               
SD(D)   0.9              0.04      25                                                                                               
CV(E)   5.6              4.5      5.4                                                                                               
==========================================                                                                                          
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                       
                                            CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                        
==================================================================================================================================  
      UNTREATDCONTROL             VEHICLE CONTROL                         .312%                              .625%                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    12.9    92.4      12.9     94.2     1.00       0     12.8     91.2     0.99     437     12.5     92.8     0.97     843       
  2    12.4   113.3      12.3    113.4     0.99       0     12.4    113.1     1.00     343     12.5    112.5     1.01     694       
  6    12.1   162.0      12.4    163.1     1.02       0     12.2    159.5     1.01     238     11.8    159.7     0.98     463       
 10    10.8   180.8      10.6    181.5     0.98       0     10.7    178.6     0.99     187      9.8    175.2     0.91     350       
 14    10.3   191.4      10.3    191.1     1.00       0     11.2    193.6     1.09     181     10.6    187.1     1.03     354       
 18    10.9   200.5      10.9    200.5     1.00       0     10.8    200.6     0.99     167     10.7    198.1     0.98     336       
 22    11.0   208.5      11.5    212.3     1.05       0     11.8    211.5     1.07     174     10.6    204.3     0.96     325       
 26    11.1   210.6      11.5    214.0     1.04       0     12.0    213.9     1.08     175     11.3    207.1     1.02     340       
 30    12.0   220.2      12.9    220.6     1.08       0     11.9    221.5     0.99     168     11.8    215.0     0.98     342       
 34    12.2   230.1      12.3    233.5     1.01       0     12.5    231.7     1.02     169     11.5    224.7     0.94     320       
 38    11.7   236.3      12.0    237.6     1.03       0     12.2    238.6     1.04     160     11.8    229.2     1.01     322       
 42    11.4   242.6      11.7    246.8     1.03       0     11.7    246.4     1.03     148     11.6    239.3     1.02     302       
 46    12.1   250.4      12.4    255.4     1.02       0     12.6    254.6     1.04     155     11.9    245.6     0.98     302       
 50    12.7   261.1      11.4    262.2     0.90       0     12.5    264.3     0.98     148     12.1    253.1     0.95     299       
 54    12.3   271.0      12.2    274.1     0.99       0     11.8    273.7     0.96     134     12.1    263.7     0.98     287       
 58    11.6   278.2      12.1    282.9     1.04       0     11.4    279.6     0.98     128     12.1    269.3     1.04     280       
 62    11.6   286.0      11.4    288.8     0.98       0     12.0    288.0     1.03     129     11.3    276.3     0.97     255       
 66    11.8   291.7      11.4    294.0     0.97       0     12.4    293.4     1.05     132     11.8    282.5     1.00     262       
 70    11.9   296.7      12.0    299.1     1.01       0     12.7    298.6     1.07     132     12.6    288.3     1.06     273       
 74    12.6   308.4      13.1    309.9     1.04       0     13.3    309.6     1.06     134     12.5    298.2     0.99     262       
 78    12.6   309.2      12.7    315.7     1.01       0     12.6    311.7     1.00     126     12.3    298.2     0.98     258       
 82    12.7   314.7      13.1    319.7     1.03       0     13.0    317.6     1.02     127     13.4    307.5     1.06     271       
 86    13.2   321.4      13.0    324.3     0.98       0     13.4    321.3     1.02     130     12.8    313.4     0.97     256       
 90    13.0   327.6      12.4    330.6     0.95       0     12.5    325.3     0.96     120     12.2    315.1     0.94     241       
 94    12.4   325.1      13.2    336.4     1.06       0     12.8    326.8     1.03     122     13.2    325.7     1.06     253       
 98    12.9   330.8      12.3    338.1     0.95       0     12.6    328.7     0.98     120     11.9    329.5     0.92     226       
102    11.9   328.6      12.7    344.4     1.07       0     13.4    332.2     1.13     126     13.6    337.3     1.14     251       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   12.1   137.1      12.0    138.0     1.00       0     12.0    135.6     1.00     301     11.7    135.1     0.96     588       
SD(D)   0.9               1.0              0.02       0      0.9              0.01     112      1.3              0.04     223       
CV(E)   7.5               8.1              1.8               7.7              0.8     37.1     11.0              4.4     37.9       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   11.5   225.2      11.7    227.4     1.01       0     11.9    227.7     1.03     164     11.4    220.3     0.99     324       
SD(D)   0.7               0.7              0.05       0      0.6              0.04      11      0.6              0.03      19       
CV(E)   6.3               6.4              4.6               5.0              3.7      6.9      5.0              3.0      5.8       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   12.4   306.9      12.4    312.2     1.01       0     12.6    308.2     1.02     128     12.4    300.4     1.01     260       
SD(D)   0.5               0.6              0.04       0      0.6              0.05       5      0.7              0.06      16       
CV(E)   4.3               4.9              3.9               4.8              4.6      3.9      5.3              6.0      6.2       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                                                                 
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                                                                    
==========================================                                                                                          
                     1.25%                                                                                                          
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       FEED/   WEIGHT  FEED (B)    DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  1    10.8     93.9     0.84    1433                                                                                               
  2    12.1    110.0     0.98    1373                                                                                               
  6    11.5    155.9     0.95     924                                                                                               
 10    10.2    173.4     0.94     738                                                                                               
 14    10.5    184.8     1.02     712                                                                                               
 18    10.4    190.6     0.95     682                                                                                               
 22    10.6    199.5     0.96     663                                                                                               
 26    10.8    201.0     0.97     670                                                                                               
 30    11.5    207.1     0.96     695                                                                                               
 34    11.4    217.6     0.93     655                                                                                               
 38    11.4    221.5     0.97     642                                                                                               
 42    10.8    227.7     0.95     595                                                                                               
 46    11.3    236.4     0.93     597                                                                                               
 50    12.0    242.6     0.94     619                                                                                               
 54    11.8    252.1     0.96     583                                                                                               
 58    11.3    258.3     0.97     545                                                                                               
 62    11.3    265.8     0.97     529                                                                                               
 66    11.6    270.8     0.98     538                                                                                               
 70    12.0    277.2     1.01     541                                                                                               
 74    12.2    285.7     0.97     535                                                                                               
 78    11.4    285.6     0.90     500                                                                                               
 82    12.2    290.6     0.96     525                                                                                               
 86    12.1    295.4     0.92     512                                                                                               
 90    12.0    300.6     0.92     500                                                                                               
 94    12.5    309.7     1.01     504                                                                                               
 98    11.4    309.6     0.88     459                                                                                               
102    11.8    309.3     0.99     475                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   11.2    133.3     0.93    1117                                                                                               
SD(D)   0.8              0.06     340                                                                                               
CV(E)   7.3              6.6     30.4                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   11.1    212.9     0.96     653                                                                                               
SD(D)   0.5              0.03      40                                                                                               
CV(E)   4.7              2.6      6.1                                                                                               
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   11.8    285.4     0.96     519                                                                                               
SD(D)   0.4              0.04      32                                                                                               
CV(E)   3.4              4.1      6.2                                                                                               
==========================================                                                                                          
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                           DIAGNOSTIC TRAILER REPORT                                                                
                                           FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                        
                                           CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                         
==================================================================================================================================  
      UNTREATDCONTROL          VEHICLE CONTROL               .312%                    .625%                    1.25%                
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               97.7  50                 97.3  50                 97.8  50                 97.6  50                 97.9  50      
  1  17.2  3302   97.7  50    17.3  3306   97.3  50    16.6  3309   97.8  50    15.5  3322   97.6  50    12.6  3323   97.9  50      
  2  17.3  4840  133.8  50    17.6  4864  134.1  50    16.9  4929  132.2  50    16.2  4869  128.9  50    15.4  4907  121.6  50      
  5  18.6  3767               18.4  3778               18.2  3775               18.1  3773               17.8  3771                 
  6  19.7  4645  252.7  50    20.0  4617  255.0  50    19.7  4643  251.7  50    19.5  4667  244.1  50    18.7  4654  236.6  50      
  9  17.5  3295               17.7  3506               17.8  3566               17.2  3561               17.0  3632                 
 10  16.7  4935  306.7  50    16.2  4911  307.9  50    16.4  4591  303.8  50    16.4  4872  293.9  50    16.3  4837  283.7  50      
 13  17.1  3618               17.6  3579               17.0  3650               16.9  3523               16.7  3488                 
 14  17.4  4839  343.3  50    17.7  4876  349.9  50    17.2  4912  341.8  50    16.5  4950  329.0  50    16.9  4986  320.1  50      
 17  18.1  3567               17.9  3392               16.6  3580               16.2  3650               15.6  3650                 
 18  17.0  4928  374.2  50    17.0  4939  377.6  50    15.9  4944  368.1  50    16.0  4957  358.0  50    15.0  4962  345.2  50      
 21  16.6  3779               16.6  3777               16.4  3543               16.5  3704               16.2  3782                 
 22  18.2  4634  393.1  50    18.3  4650  396.7  50    17.6  4395  381.7  50    17.6  4620  375.1  49    17.1  4729  360.5  50      
 25  18.4  3468               19.1  3615               19.0  3558               18.0  3545               18.3  3629                 
 26  18.9  4771  403.5  50    20.2  4779  409.9  50    19.3  4698  396.5  49    18.0  4719  387.4  49    18.2  4811  372.8  50      
 29  18.9  3580               18.6  3332               18.4  3222               18.8  3009               17.6  3130                 
 30  19.6  4821  420.5  50    19.1  4869  423.9  50    18.5  4761  413.2  49    19.4  4669  403.9  48    17.4  4911  388.4  50      
 33  18.1  3750               18.4  3740               17.9  3700               18.1  3636               17.8  3773                 
 34  19.2  4644  439.2  50    19.3  4662  443.8  50    18.4  4310  430.0  49    18.8  4518  419.6  48    18.5  4725  403.6  50      
 37  18.8  3626               18.9  3412               18.2  3561               17.7  3501               17.8  3662                 
 38  19.4  4275  444.5  50    19.1  4611  448.1  50    19.2  4473  438.0  49    18.3  4361  428.5  48    18.4  4583  410.6  50      
 41  18.8  3471               18.8  3617               18.1  3545               19.0  3509               17.5  3637                 
 42  18.1  4806  458.4  50    18.1  4822  463.1  50    17.4  4741  449.4  49    18.3  4621  439.7  48    16.3  4859  420.5  50      
 45  18.7  3700               18.9  3694               18.9  3626               18.6  3546               17.9  3700                 
 46  18.5  4795  465.6  50    18.7  4850  468.4  50    18.2  4712  455.9  49    18.5  4581  446.4  48    18.0  4813  426.7  50      
 49  18.6  3685               20.1  3655               19.6  3467               19.4  3386               18.9  3534                 
 50  18.4  4796  467.5  50    19.8  4774  474.8  50    18.7  4719  461.6  49    18.4  4641  452.5  48    17.7  4819  433.2  50      
 53  18.5  3360               18.6  3506               18.3  3436               18.4  3368               18.2  3511                 
 54  18.0  4848  473.8  50    17.9  4869  484.0  50    17.3  4846  467.8  49    17.8  4770  458.2  48    17.1  4985  437.9  50      
 57  16.7  3660               16.4  3666               16.0  3578               16.5  3487               15.8  3631                 
 58  16.8  4776  477.9  50    17.1  4480  481.5  50    15.8  4690  468.3  49    16.2  4629  463.3  48    15.6  4804  441.2  50      
 61  16.1  3514               16.6  3550               16.2  3415               16.4  3438               16.1  3578                 
 62  16.0  4879  472.2  50    16.9  4570  476.1  50    16.4  4645  465.5  48    16.6  4335  457.4  48    16.0  4836  438.2  50      
 65  18.1  3595               18.7  3474               19.4  3445               18.7  3402               18.3  3575                 
 66  18.0  4785  479.2  50    18.5  4716  488.7  49    18.3  4654  471.3  48    17.6  4388  461.3  48    17.3  4897  444.8  50      
 69  16.7  3630               17.0  3543               16.8  3521               17.0  3516               16.1  3684                 
 70  17.1  4741  478.1  50    17.0  4411  480.2  49    16.9  4548  471.8  48    17.2  4577  463.7  48    15.6  4494  442.2  50      
 73  18.6  3289               18.3  3119               18.0  3444               17.7  3202               17.1  3577                 
 74  17.9  4564  482.7  49    17.8  4284  485.0  46    18.4  4466  475.2  48    17.9  4325  468.0  46    17.9  4619  444.6  49      
 77  17.1  3456               17.5  3312               17.2  3456               16.6  3146               16.1  3528                 
 78  18.1  4418  482.4  48    18.2  4255  486.3  46    18.4  4461  476.3  48    18.0  4121  468.7  44    17.4  4635  444.3  49      
 81  17.6  3576               17.3  3409               17.1  3591               17.3  3150               16.2  3566                 
 82  17.7  4506  485.1  48    17.3  4016  490.9  45    16.4  4576  475.6  48    17.0  4145  469.5  43    16.1  4753  448.2  49      
 85  16.7  3239               17.1  2980               16.7  3372               16.5  2900               17.2  3247                 
 86  17.8  3931  478.0  46    16.9  4050  486.8  42    16.6  4489  474.4  46    17.3  3731  466.6  40    16.6  4805  445.0  49      
 89  17.0  3089               18.1  2739               17.3  3235               16.2  2688               16.8  3450                 
 90  17.4  4095  480.0  43    17.7  3346  492.1  37    17.0  4373  474.6  45    16.6  2736  460.2  35    15.9  4815  440.4  49      
 93  17.7  2849               16.3  2514               16.5  3123               16.6  2330               16.3  3365                 
 94  17.3  4044  476.7  42    16.6  3122  484.6  35    16.3  4180  475.4  43    16.3  3132  461.4  33    14.8  4726  443.5  48      
 97  16.5  2761               17.5  2303               15.8  2929               15.1  2204               16.4  3166                 
==================================================================================================================================  
                                                                                                                                   
                                           DIAGNOSTIC TRAILER REPORT                                                                
                                           FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                        
                                           CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                         
==================================================================================================================================  
      UNTREATDCONTROL          VEHICLE CONTROL               .312%                    .625%                    1.25%                
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS     
=================================================================================================================================== 
 98  15.8  3821  479.8  39    17.0  3218  488.3  33    14.8  4121  465.6  42    14.9  3014  451.2  30    15.6  4483  439.2  45      
101  14.9  2514               16.6  2442               15.8  2813               14.9  2075               16.6  3199                 
102  16.0  2829  469.8  36    17.5  2861  486.9  32    16.2  3633  467.3  38    15.0  2494  443.0  28    15.7  4128  434.8  43      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          197.7                    198.6                    196.4                    191.1                    184.9          
14 TO 52         421.0                    425.6                    413.6                    404.0                    388.2          
 > 52            478.1                    485.5                    471.5                    461.0                    441.9          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                           DIAGNOSTIC TRAILER REPORT                                                                
                                           FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                      
                                           CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                         
==================================================================================================================================  
      UNTREATDCONTROL          VEHICLE CONTROL               .312%                    .625%                    1.25%                
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               92.4  50                 94.2  50                 91.2  50                 92.8  50                 93.9  50      
  1  12.9  3441   92.4  50    12.9  3450   94.2  50    12.8  3445   91.2  50    12.5  3450   92.8  50    10.8  3442   93.9  50      
  2  12.4  4855  113.3  50    12.3  4848  113.4  50    12.4  4870  113.1  50    12.5  4897  112.5  50    12.1  4916  110.0  50      
  5  12.5  3505               12.5  3501               12.1  3150               12.2  3510               11.9  3498                 
  6  12.1  4795  162.0  50    12.4  4776  163.1  50    12.2  4807  159.5  50    11.8  4877  159.7  50    11.5  4839  155.9  50      
  9  11.8  3470               11.8  3471               11.9  3480               10.6  3391               11.0  3480                 
 10  10.8  4849  180.8  50    10.6  4923  181.5  50    10.7  4965  178.6  50     9.8  4850  175.2  49    10.2  4915  173.4  50      
 13  10.1  3601               10.1  3249               11.1  3529               10.2  3519                9.9  3611                 
 14  10.3  4784  191.4  50    10.3  4737  191.1  50    11.2  4687  193.6  49    10.6  4718  187.1  49    10.5  4721  184.8  50      
 17  10.4  3616               10.4  3635               10.1  3591               10.5  3592                9.5  3670                 
 18  10.9  4778  200.5  50    10.9  4792  200.5  50    10.8  4704  200.6  49    10.7  4714  198.1  49    10.4  4822  190.6  50      
 21  11.9  3456               12.1  3456               12.1  3391               11.2  3415               11.0  3506                 
 22  11.0  4750  208.5  50    11.5  4762  212.3  50    11.8  4677  211.5  49    10.6  4664  204.3  49    10.6  4801  199.5  50      
 25  11.6  3585               11.9  3580               12.0  3504               11.1  3508               10.9  3580                 
 26  11.1  4830  210.6  50    11.5  4841  214.0  50    12.0  4750  213.9  49    11.3  4760  207.1  49    10.8  4282  201.0  49      
 29  11.7  3641               10.4  3279               11.5  3572               11.5  3503               10.9  3577                 
 30  12.0  4803  220.2  49    12.9  4835  220.6  50    11.9  4745  221.5  49    11.8  4658  215.0  48    11.5  4760  207.1  49      
 33  10.5  3783               11.4  3864               11.4  3792               10.6  3716               10.1  3793                 
 34  12.2  4516  230.1  49    12.3  4626  233.5  50    12.5  4548  231.7  49    11.5  4471  224.7  48    11.4  4582  217.6  49      
 37  12.4  3165               11.6  3600               12.3  3539               11.9  3476               11.3  3185                 
 38  11.7  4499  236.3  49    12.0  4607  237.6  50    12.2  4579  238.6  49    11.8  4457  229.2  48    11.4  4523  221.5  49      
 41  11.8  3469               12.1  3540               12.0  3498               12.0  3411               11.7  3480                 
 42  11.4  4736  242.6  49    11.7  4847  246.8  50    11.7  4765  246.4  49    11.6  4679  239.3  48    10.8  4787  227.7  49      
 45  12.4  3533               12.6  3605               13.4  3528               11.9  3451               11.5  3518                 
 46  12.1  4818  250.4  49    12.4  4852  255.4  50    12.6  4842  254.6  49    11.9  4633  245.6  48    11.3  4721  236.4  49      
 49  12.7  3691               12.0  3756               12.6  3646               12.0  3557               11.9  3620                 
 50  12.7  4715  261.1  49    11.4  4821  262.2  50    12.5  4691  264.3  49    12.1  4586  253.1  48    12.0  4674  242.6  49      
 53  12.4  3427               12.5  3501               12.4  3434               12.2  3370               12.2  3440                 
 54  12.3  4669  271.0  49    12.2  4785  274.1  50    11.8  4708  273.7  49    12.1  4620  263.7  48    11.8  4729  252.1  49      
 57  12.3  3416               11.9  3500               11.6  3419               12.7  3360               11.4  3425                 
 58  11.6  4676  278.2  49    12.1  4777  282.9  50    11.4  4762  279.6  49    12.1  4212  269.3  48    11.3  4728  258.3  49      
 61  11.6  3582               11.4  3657               11.1  3556               10.9  3457               11.6  3514                 
 62  11.6  4657  286.0  49    11.4  4711  288.8  50    12.0  4693  288.0  49    11.3  4587  276.3  48    11.3  4671  265.8  49      
 65  11.7  3529               11.7  3602               11.7  3536               11.5  3464               11.7  3538                 
 66  11.8  4742  291.7  49    11.4  4849  294.0  50    12.4  4677  293.4  49    11.8  4680  282.5  48    11.6  4716  270.8  49      
 69  13.3  3409               13.2  3471               13.5  3144               13.6  3190               13.0  3410                 
 70  11.9  4844  296.7  49    12.0  4949  299.1  50    12.7  4858  298.6  49    12.6  4480  288.3  46    12.0  4792  277.2  49      
 73  12.8  3435               13.2  3547               13.3  3528               12.1  3242               12.1  3511                 
 74  12.6  4588  308.4  49    13.1  4698  309.9  50    13.3  4574  309.6  49    12.5  4209  298.2  45    12.2  4595  285.7  49      
 77  12.2  3601               12.5  3522               12.8  3602               12.5  3307               11.6  3606                 
 78  12.6  4595  309.2  49    12.7  4522  315.7  48    12.6  4678  311.7  49    12.3  4311  298.2  45    11.4  4614  285.6  48      
 81  13.6  3515               13.4  3495               13.7  3465               14.3  3180               12.7  3471                 
 82  12.7  4552  314.7  48    13.1  4589  319.7  48    13.0  4621  317.6  48    13.4  4250  307.5  44    12.2  4556  290.6  47      
 85  13.3  3373               13.2  3442               13.4  3438               13.3  3141               12.3  3249                 
 86  13.2  4487  321.4  47    13.0  4603  324.3  48    13.4  4622  321.3  48    12.8  4252  313.4  44    12.1  4365  295.4  45      
 89  12.7  3256               12.2  3327               12.3  3265               12.9  2977               12.9  3134                 
 90  13.0  4480  327.6  45    12.4  3979  330.6  46    12.5  4366  325.3  45    12.2  4108  315.1  42    12.0  4256  300.6  44      
 93  12.4  3170               13.6  3180               13.0  3129               13.5  2947               13.8  2933                 
 94  12.4  4327  325.1  44    13.2  4417  336.4  45    12.8  4285  326.8  44    13.2  3966  325.7  41    12.5  4002  309.7  41      
 97  12.1  3073               11.5  3225               12.3  3041               12.0  2729               11.1  2945                 
==================================================================================================================================  
                                                                                                                                   
                                           DIAGNOSTIC TRAILER REPORT                                                                
                                           FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                      
                                           CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                         
==================================================================================================================================  
      UNTREATDCONTROL          VEHICLE CONTROL               .312%                    .625%                    1.25%                
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS     
=================================================================================================================================== 
 98  12.9  3723  330.8  40    12.3  3969  338.1  42    12.6  3702  328.7  39    11.9  3687  329.5  39    11.4  3636  309.6  39      
101  12.2  2699               12.8  2709               13.3  2542               14.0  2707               11.8  2614                 
102  11.9  3575  328.6  37    12.7  3391  344.4  37    13.4  3399  332.2  35    13.6  3606  337.3  37    11.8  3521  309.3  36      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          137.1                    138.0                    135.6                    135.1                    133.3          
14 TO 52         225.2                    227.4                    227.7                    220.3                    212.9          
 > 52            306.9                    312.2                    308.2                    300.4                    285.4          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.