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TDMS Study 56111-03 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                                TRANS-CINNAMALDEHYDE                                          DATE: 06/01/01  
EXPERIMENT: 56111 TEST: 03                                                                                        TIME: 11:32:20    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C56111B     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE COLUMBUS LABORATORY                     TRANS-CINNAMALDEHYDE                                        DATE: 06/01/01    
EXPERIMENT: 56111 TEST: 03                                                                                        TIME: 11:41:36    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: DOSED FEED                                             NTP:  56111B      
CONT: N01-ES-55384                                                                                                CAS: 14371-10-9   
                                                                                                                                   
                                                                                                                                    
                                         MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                         
                                         TWO YEAR DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                          
=================================================================================================================================== 
WEEK     UNTREATDCONTROL        VEHICLE CONTROL          .312%                    .625%                    1.25%                    
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        97.7       50        97.3     99.6    50      97.8    100.1    50      97.6     99.9    50      97.9    100.2    50      
  1        97.7       50        97.3     99.6    50      97.8    100.1    50      97.6     99.9    50      97.9    100.2    50      
  2       133.8       50       134.1    100.2    50     132.2     98.8    50     128.9     96.3    50     121.6     90.9    50      
  6       252.7       50       255.0    100.9    50     251.7     99.6    50     244.1     96.6    50     236.6     93.6    50      
 10       306.7       50       307.9    100.4    50     303.8     99.1    50     293.9     95.8    50     283.7     92.5    50      
 14       343.3       50       349.9    101.9    50     341.8     99.6    50     329.0     95.8    50     320.1     93.2    50      
 18       374.2       50       377.6    100.9    50     368.1     98.4    50     358.0     95.7    50     345.2     92.3    50      
 22       393.1       50       396.7    100.9    50     381.7     97.1    50     375.1     95.4    49     360.5     91.7    50      
 26       403.5       50       409.9    101.6    50     396.5     98.3    49     387.4     96.0    49     372.8     92.4    50      
 30       420.5       50       423.9    100.8    50     413.2     98.3    49     403.9     96.1    48     388.4     92.4    50      
 34       439.2       50       443.8    101.0    50     430.0     97.9    49     419.6     95.5    48     403.6     91.9    50      
 38       444.5       50       448.1    100.8    50     438.0     98.5    49     428.5     96.4    48     410.6     92.4    50      
 42       458.4       50       463.1    101.0    50     449.4     98.0    49     439.7     95.9    48     420.5     91.7    50      
 46       465.6       50       468.4    100.6    50     455.9     97.9    49     446.4     95.9    48     426.7     91.6    50      
 50       467.5       50       474.8    101.6    50     461.6     98.7    49     452.5     96.8    48     433.2     92.7    50      
 54       473.8       50       484.0    102.2    50     467.8     98.7    49     458.2     96.7    48     437.9     92.4    50      
 58       477.9       50       481.5    100.8    50     468.3     98.0    49     463.3     96.9    48     441.2     92.3    50      
 62       472.2       50       476.1    100.8    50     465.5     98.6    48     457.4     96.9    48     438.2     92.8    50      
 66       479.2       50       488.7    102.0    49     471.3     98.4    48     461.3     96.3    48     444.8     92.8    50      
 70       478.1       50       480.2    100.4    49     471.8     98.7    48     463.7     97.0    48     442.2     92.5    50      
 74       482.7       49       485.0    100.5    46     475.2     98.4    48     468.0     97.0    46     444.6     92.1    49      
 78       482.4       48       486.3    100.8    46     476.3     98.7    48     468.7     97.2    44     444.3     92.1    49      
 82       485.1       48       490.9    101.2    45     475.6     98.0    48     469.5     96.8    43     448.2     92.4    49      
 86       478.0       46       486.8    101.8    42     474.4     99.2    46     466.6     97.6    40     445.0     93.1    49      
 90       480.0       43       492.1    102.5    37     474.6     98.9    45     460.2     95.9    35     440.4     91.8    49      
 94       476.7       42       484.6    101.7    35     475.4     99.7    43     461.4     96.8    33     443.5     93.0    48      
 98       479.8       39       488.3    101.8    33     465.6     97.0    42     451.2     94.0    30     439.2     91.5    45      
102       469.8       36       486.9    103.6    32     467.3     99.5    38     443.0     94.3    28     434.8     92.6    43      
TERM. SAC.            29                         31                       36                       27                       41      
=================================================================================================================================== 
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                                         MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                       
                                         TWO YEAR DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                          
=================================================================================================================================== 
WEEK     UNTREATDCONTROL        VEHICLE CONTROL          .312%                    .625%                    1.25%                    
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        92.4       50        94.2    101.9    50      91.2     98.7    50      92.8    100.4    50      93.9    101.6    50      
  1        92.4       50        94.2    101.9    50      91.2     98.7    50      92.8    100.4    50      93.9    101.6    50      
  2       113.3       50       113.4    100.1    50     113.1     99.8    50     112.5     99.3    50     110.0     97.1    50      
  6       162.0       50       163.1    100.7    50     159.5     98.5    50     159.7     98.6    50     155.9     96.2    50      
 10       180.8       50       181.5    100.4    50     178.6     98.8    50     175.2     96.9    49     173.4     95.9    50      
 14       191.4       50       191.1     99.8    50     193.6    101.1    49     187.1     97.8    49     184.8     96.6    50      
 18       200.5       50       200.5    100.0    50     200.6    100.0    49     198.1     98.8    49     190.6     95.1    50      
 22       208.5       50       212.3    101.8    50     211.5    101.4    49     204.3     98.0    49     199.5     95.7    50      
 26       210.6       50       214.0    101.6    50     213.9    101.6    49     207.1     98.3    49     201.0     95.4    49      
 30       220.2       49       220.6    100.2    50     221.5    100.6    49     215.0     97.6    48     207.1     94.1    49      
 34       230.1       49       233.5    101.5    50     231.7    100.7    49     224.7     97.7    48     217.6     94.6    49      
 38       236.3       49       237.6    100.6    50     238.6    101.0    49     229.2     97.0    48     221.5     93.7    49      
 42       242.6       49       246.8    101.7    50     246.4    101.6    49     239.3     98.6    48     227.7     93.9    49      
 46       250.4       49       255.4    102.0    50     254.6    101.7    49     245.6     98.1    48     236.4     94.4    49      
 50       261.1       49       262.2    100.4    50     264.3    101.2    49     253.1     96.9    48     242.6     92.9    49      
 54       271.0       49       274.1    101.1    50     273.7    101.0    49     263.7     97.3    48     252.1     93.0    49      
 58       278.2       49       282.9    101.7    50     279.6    100.5    49     269.3     96.8    48     258.3     92.8    49      
 62       286.0       49       288.8    101.0    50     288.0    100.7    49     276.3     96.6    48     265.8     92.9    49      
 66       291.7       49       294.0    100.8    50     293.4    100.6    49     282.5     96.8    48     270.8     92.8    49      
 70       296.7       49       299.1    100.8    50     298.6    100.6    49     288.3     97.2    46     277.2     93.4    49      
 74       308.4       49       309.9    100.5    50     309.6    100.4    49     298.2     96.7    45     285.7     92.6    49      
 78       309.2       49       315.7    102.1    48     311.7    100.8    49     298.2     96.4    45     285.6     92.4    48      
 82       314.7       48       319.7    101.6    48     317.6    100.9    48     307.5     97.7    44     290.6     92.3    47      
 86       321.4       47       324.3    100.9    48     321.3    100.0    48     313.4     97.5    44     295.4     91.9    45      
 90       327.6       45       330.6    100.9    46     325.3     99.3    45     315.1     96.2    42     300.6     91.8    44      
 94       325.1       44       336.4    103.5    45     326.8    100.5    44     325.7    100.2    41     309.7     95.3    41      
 98       330.8       40       338.1    102.2    42     328.7     99.4    39     329.5     99.6    39     309.6     93.6    39      
102       328.6       37       344.4    104.8    37     332.2    101.1    35     337.3    102.6    37     309.3     94.1    36      
TERM. SAC.            34                         36                       33                       35                       33      
=================================================================================================================================== 
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.