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TDMS Study 56111-03 Pathology Tables

                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 12/10/02       
EXPERIMENT: 56111 TEST: 03                                                                                     TIME: 10:51:06       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 14371-10-9      
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Parathyroid Gland                                                                  
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Salivary Glands                                                                    
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 12/10/02       
EXPERIMENT: 56111 TEST: 03                                                                                     TIME: 10:51:06       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 14371-10-9      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  TRANS-CINNAMALDEHYDE                                                                            
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Benign                                                                      
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS                                            
Clitoral/Preputial Gland               Carcinoma or Adenoma                                                                         
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Skin                                                                                                                                
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom                                                                                                                 
                                       Fibrosarcoma                                                                                 
Testes                                 Adenoma                                                                                      
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Islets, Pancreatic                     Carcinoma                                                                                    
===============================================================                                                                     
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                   TRANS-CINNAMALDEHYDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    4/50 (8%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/44.44      4/45.17      4/40.08      0/47.85     |0/45.04      2/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     11.3%        8.9%         10.0%        0.0%        |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/29 (17%)   4/36 (11%)   2/27 (7%)    0/41 (0%)   |0/34 (0%)    2/33 (6%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      676          ---         |---          735 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.015N*    P=0.364N     P=0.566N     P=0.012N*   |P=0.408N     P=0.232      (e)          (e)          | 
|POLY 3             |     P=0.022N*    P=0.490N     P=0.565N     P=0.025N*   |P=0.411N     P=0.236      (e)          (e)          | 
|POLY 1.5           |     P=0.025N*    P=0.500N     P=0.546N     P=0.027N*   |P=0.409N     P=0.236      (e)          (e)          | 
|POLY 6             |     P=0.019N*    P=0.473N     P=0.584N     P=0.021N*   |P=0.413N     P=0.234      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.022N*    P=0.364N     P=0.610N     (e)         |(e)          P=0.232      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.029N*    P=0.500N     P=0.500N     P=0.028N*   |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.022N*    (e)          (e)          (e)         |P=0.250N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    4/50 (8%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/44.44      4/45.17      4/40.08      0/47.85     |1/45.04      2/44.73      1/43.67      0/44.16      | 
|POLY-3 PERCENT (g) |     11.3%        8.9%         10.0%        0.0%        |2.2%         4.5%         2.3%         0.0%         | 
|TERMINAL (d)       |     5/29 (17%)   4/36 (11%)   2/27 (7%)    0/41 (0%)   |1/34 (3%)    2/33 (6%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      676          ---         |735 (T)      735 (T)      498          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.015N*    P=0.364N     P=0.566N     P=0.012N*   |P=0.251N     P=0.490      P=0.757      P=0.506N     | 
|POLY 3             |     P=0.022N*    P=0.490N     P=0.565N     P=0.025N*   |P=0.254N     P=0.498      P=0.754      P=0.504N     | 
|POLY 1.5           |     P=0.025N*    P=0.500N     P=0.546N     P=0.027N*   |P=0.252N     P=0.498      P=0.754      P=0.502N     | 
|POLY 6             |     P=0.019N*    P=0.473N     P=0.584N     P=0.021N*   |P=0.255N     P=0.495      P=0.756      P=0.506N     | 
|LOGISTIC REGRESSION|     P=0.022N*    P=0.364N     P=0.610N     (e)         |P=0.245N     P=0.490      P=0.751N     (e)          | 
|COCH-ARM / FISHERS |     P=0.029N*    P=0.500N     P=0.500N     P=0.028N*   |P=0.248N     P=0.500      P=0.747      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.022N*    (e)          (e)          (e)         |P=0.228N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    2/50 (4%)    0/50 (0%)   |4/49 (8%)    4/50 (8%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/44.58      1/44.33      2/39.95      0/47.85     |4/44.09      4/44.88      1/42.98      2/44.16      | 
|POLY-3 PERCENT (g) |     4.5%         2.3%         5.0%         0.0%        |9.1%         8.9%         2.3%         4.5%         | 
|TERMINAL (d)       |     1/29 (3%)    1/36 (3%)    1/27 (4%)    0/41 (0%)   |3/33 (9%)    3/33 (9%)    1/35 (3%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     696          731 (T)      655          ---         |723          697          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.164N     P=0.450N     P=0.630      P=0.187N    |P=0.185N     P=0.636      P=0.167N     P=0.340N     | 
|POLY 3             |     P=0.184N     P=0.502N     P=0.654      P=0.222N    |P=0.188N     P=0.634N     P=0.186N     P=0.336N     | 
|POLY 1.5           |     P=0.190N     P=0.507N     P=0.666      P=0.229N    |P=0.186N     P=0.634N     P=0.185N     P=0.333N     | 
|POLY 6             |     P=0.176N     P=0.493N     P=0.640      P=0.212N    |P=0.189N     P=0.636N     P=0.185N     P=0.339N     | 
|LOGISTIC REGRESSION|     P=0.191N     P=0.490N     P=0.657      P=0.224N    |P=0.185N     P=0.645N     P=0.170N     P=0.334N     | 
|COCH-ARM / FISHERS |     P=0.199N     P=0.508N     P=0.691N     P=0.247N    |P=0.182N     P=0.631N     P=0.181N     P=0.329N     | 
|ORDER RESTRICTED   |     P=0.144N     (e)          (e)          (e)         |P=0.215N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/49 (4%)    3/50 (6%)    1/50 (2%)   |3/49 (6%)    1/50 (2%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/44.44      2/45.38      3/40.55      1/47.85     |3/44.55      1/44.88      2/42.98      2/44.56      | 
|POLY-3 PERCENT (g) |     6.8%         4.4%         7.4%         2.1%        |6.7%         2.2%         4.7%         4.5%         | 
|TERMINAL (d)       |     3/29 (10%)   0/36 (0%)    1/27 (4%)    1/41 (2%)   |1/33 (3%)    0/33 (0%)    2/35 (6%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     731 (T)      404          577          731 (T)     |597          697          735 (T)      634          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.210N     P=0.439N     P=0.619      P=0.191N    |P=0.505N     P=0.314N     P=0.490N     P=0.511N     | 
|POLY 3             |     P=0.241N     P=0.490N     P=0.620      P=0.279N    |P=0.500N     P=0.302N     P=0.516N     P=0.500N     | 
|POLY 1.5           |     P=0.250N     P=0.502N     P=0.631      P=0.291N    |P=0.498N     P=0.301N     P=0.511N     P=0.497N     | 
|POLY 6             |     P=0.228N     P=0.473N     P=0.608      P=0.263N    |P=0.501N     P=0.306N     P=0.518N     P=0.503N     | 
|LOGISTIC REGRESSION|     P=0.273N     P=0.474N     P=0.647      P=0.191N    |P=0.495N     P=0.296N     P=0.505N     P=0.486N     | 
|COCH-ARM / FISHERS |     P=0.261N     P=0.510N     P=0.661N     P=0.309N    |P=0.494N     P=0.301N     P=0.500N     P=0.490N     | 
|ORDER RESTRICTED   |     P=0.239N     (e)          (e)          (e)         |P=0.398N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/49 (6%)    5/50 (10%)   1/50 (2%)   |7/49 (14%)   5/50 (10%)   3/49 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     5/44.58      3/45.38      5/40.83      1/47.85     |7/44.60      5/45.03      3/42.98      4/44.56      | 
|POLY-3 PERCENT (g) |     11.2%        6.6%         12.3%        2.1%        |15.7%        11.1%        7.0%         9.0%         | 
|TERMINAL (d)       |     4/29 (14%)   1/36 (3%)    2/27 (7%)    1/41 (2%)   |4/33 (12%)   3/33 (9%)    3/35 (9%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     696          404          577          731 (T)     |597          697          735 (T)      634          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.078N     P=0.287N     P=0.550      P=0.048N*   |P=0.202N     P=0.392N     P=0.150N     P=0.276N     | 
|POLY 3             |     P=0.093N     P=0.346N     P=0.575      P=0.086N    |P=0.198N     P=0.372N     P=0.172N     P=0.261N     | 
|POLY 1.5           |     P=0.100N     P=0.359N     P=0.589      P=0.093N    |P=0.195N     P=0.370N     P=0.168N     P=0.257N     | 
|POLY 6             |     P=0.084N     P=0.327N     P=0.560      P=0.077N    |P=0.199N     P=0.377N     P=0.173N     P=0.265N     | 
|LOGISTIC REGRESSION|     P=0.114N     P=0.354N     P=0.589      P=0.066N    |P=0.197N     P=0.368N     P=0.166N     P=0.255N     | 
|COCH-ARM / FISHERS |     P=0.110N     P=0.369N     P=0.630N     P=0.102N    |P=0.190N     P=0.365N     P=0.159N     P=0.251N     | 
|ORDER RESTRICTED   |     P=0.072N     (e)          (e)          (e)         |P=0.186N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.44      0/45.17      1/39.85      0/47.85     |0/45.04      1/44.73      0/42.98      2/44.31      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.5%         0.0%        |0.0%         2.2%         0.0%         4.5%         | 
|TERMINAL (d)       |     1/29 (3%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |0/34 (0%)    1/33 (3%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     731 (T)      ---          682          ---         |---          735 (T)      ---          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.370N     P=0.457N     P=0.723      P=0.431N    |P=0.138      P=0.494      (e)          P=0.236      | 
|POLY 3             |     P=0.397N     P=0.497N     P=0.736      P=0.485N    |P=0.137      P=0.499      (e)          P=0.233      | 
|POLY 1.5           |     P=0.400N     P=0.500N     P=0.744      P=0.492N    |P=0.138      P=0.499      (e)          P=0.235      | 
|POLY 6             |     P=0.393N     P=0.491N     P=0.728      P=0.476N    |P=0.136      P=0.497      (e)          P=0.232      | 
|LOGISTIC REGRESSION|     P=0.399N     (e)          P=0.736      (e)         |P=0.136      P=0.494      (e)          P=0.234      | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.500N     P=0.753N     P=0.500N    |P=0.140      P=0.500      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.237N     (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.44      0/45.17      0/39.67      1/47.85     |2/45.34      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.1%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/36 (0%)    0/27 (0%)    1/41 (2%)   |1/34 (3%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          731 (T)     |652          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.239      (e)          (e)          P=0.569     |P=0.120N     P=0.243N     P=0.244N     P=0.251N     | 
|POLY 3             |     P=0.209      (e)          (e)          P=0.515     |P=0.114N     P=0.240N     P=0.249N     P=0.243N     | 
|POLY 1.5           |     P=0.205      (e)          (e)          P=0.508     |P=0.114N     P=0.239N     P=0.247N     P=0.241N     | 
|POLY 6             |     P=0.214      (e)          (e)          P=0.524     |P=0.112N     P=0.243N     P=0.250N     P=0.246N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.569     |P=0.115N     P=0.237N     P=0.241N     P=0.236N     | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.116N     P=0.247N     P=0.253N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.134      (e)          (e)          (e)         |P=0.031N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.44      0/45.17      1/39.85      1/47.85     |2/45.34      1/44.73      0/42.98      2/44.31      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.5%         2.1%        |4.4%         2.2%         0.0%         4.5%         | 
|TERMINAL (d)       |     1/29 (3%)    0/36 (0%)    0/27 (0%)    1/41 (2%)   |1/34 (3%)    1/33 (3%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     731 (T)      ---          682          731 (T)     |652          735 (T)      ---          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.594      P=0.457N     P=0.723      P=0.683N    |P=0.582      P=0.507N     P=0.244N     P=0.681      | 
|POLY 3             |     P=0.561      P=0.497N     P=0.736      P=0.744N    |P=0.584      P=0.505N     P=0.249N     P=0.686      | 
|POLY 1.5           |     P=0.552      P=0.500N     P=0.744      P=0.751N    |P=0.586      P=0.503N     P=0.247N     P=0.689      | 
|POLY 6             |     P=0.571      P=0.491N     P=0.728      P=0.733N    |P=0.584      P=0.509N     P=0.250N     P=0.682      | 
|LOGISTIC REGRESSION|     P=0.557      (e)          P=0.736      P=0.683N    |P=0.586      P=0.501N     P=0.241N     P=0.693      | 
|COCH-ARM / FISHERS |     P=0.539      P=0.500N     P=0.753N     P=0.753N    |P=0.590      P=0.500N     P=0.253N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.520      (e)          (e)          (e)         |P=0.409      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   6/50 (12%)   1/50 (2%)   |2/50 (4%)    2/50 (4%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/44.65      6/45.17      6/40.04      1/47.85     |2/45.04      2/44.73      2/42.98      2/44.31      | 
|POLY-3 PERCENT (g) |     4.5%         13.3%        15.0%        2.1%        |4.4%         4.5%         4.7%         4.5%         | 
|TERMINAL (d)       |     1/29 (3%)    6/36 (17%)   5/27 (19%)   1/41 (2%)   |2/34 (6%)    2/33 (6%)    2/35 (6%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     676          731 (T)      624          731 (T)     |735 (T)      735 (T)      735 (T)      694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.171N     P=0.205      P=0.106      P=0.407N    |P=0.591      P=0.685      P=0.685N     P=0.686      | 
|POLY 3             |     P=0.229N     P=0.136      P=0.099      P=0.476N    |P=0.587      P=0.692      P=0.677      P=0.688      | 
|POLY 1.5           |     P=0.249N     P=0.132      P=0.110      P=0.487N    |P=0.590      P=0.692      P=0.679      P=0.690      | 
|POLY 6             |     P=0.202N     P=0.143      P=0.089      P=0.461N    |P=0.586      P=0.690      P=0.678      P=0.687      | 
|LOGISTIC REGRESSION|     P=0.231N     P=0.157      P=0.091      P=0.487N    |P=0.586      P=0.685      P=0.685N     P=0.685      | 
|COCH-ARM / FISHERS |     P=0.277N     P=0.134      P=0.134      P=0.500N    |P=0.595      P=0.691N     P=0.684      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.092N     (e)          (e)          (e)         |P=0.734      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.44      0/45.17      2/39.67      1/47.85     |1/45.04      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         5.0%         2.1%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/36 (0%)    2/27 (7%)    1/41 (2%)   |1/34 (3%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          731 (T)      731 (T)     |735 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.315      (e)          P=0.222      P=0.569     |P=0.307N     P=0.506N     P=0.494N     P=0.506N     | 
|POLY 3             |     P=0.276      (e)          P=0.213      P=0.515     |P=0.306N     P=0.501N     P=0.509N     P=0.504N     | 
|POLY 1.5           |     P=0.264      (e)          P=0.220      P=0.508     |P=0.306N     P=0.501N     P=0.508N     P=0.502N     | 
|POLY 6             |     P=0.293      (e)          P=0.204      P=0.524     |P=0.304N     P=0.503N     P=0.509N     P=0.506N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.222      P=0.569     |P=0.307N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |P=0.306N     P=0.500N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.149      (e)          (e)          (e)         |P=0.124N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   8/50 (16%)   2/50 (4%)   |3/50 (6%)    2/50 (4%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/44.65      6/45.17      8/40.04      2/47.85     |3/45.04      2/44.73      2/42.98      2/44.31      | 
|POLY-3 PERCENT (g) |     4.5%         13.3%        20.0%        4.2%        |6.7%         4.5%         4.7%         4.5%         | 
|TERMINAL (d)       |     1/29 (3%)    6/36 (17%)   7/27 (26%)   2/41 (5%)   |3/34 (9%)    2/33 (6%)    2/35 (6%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     676          731 (T)      624          731 (T)     |735 (T)      735 (T)      735 (T)      694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.304N     P=0.205      P=0.034 *    P=0.586N    |P=0.438N     P=0.514N     P=0.487N     P=0.511N     | 
|POLY 3             |     P=0.402N     P=0.136      P=0.028 *    P=0.669N    |P=0.440N     P=0.503N     P=0.521N     P=0.507N     | 
|POLY 1.5           |     P=0.430N     P=0.132      P=0.033 *    P=0.680N    |P=0.437N     P=0.502N     P=0.518N     P=0.505N     | 
|POLY 6             |     P=0.363N     P=0.143      P=0.024 *    P=0.652N    |P=0.440N     P=0.506N     P=0.520N     P=0.510N     | 
|LOGISTIC REGRESSION|     P=0.389N     P=0.157      P=0.025 *    P=0.669N    |P=0.442N     P=0.514N     P=0.487N     P=0.514N     | 
|COCH-ARM / FISHERS |     P=0.467N     P=0.134      P=0.046 *    P=0.691N    |P=0.433N     P=0.500N     P=0.510N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.139N     (e)          (e)          (e)         |P=0.507N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.44      0/45.17      0/39.67      0/47.85     |1/45.04      0/44.73      3/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         7.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |1/34 (3%)    0/33 (0%)    3/35 (9%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.505N     P=0.506N     P=0.315      P=0.506N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.508N     P=0.501N     P=0.288      P=0.504N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.505N     P=0.501N     P=0.291      P=0.502N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.511N     P=0.503N     P=0.289      P=0.506N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.505N     (e)          P=0.315      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.501N     P=0.500N     P=0.301      P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.265N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.44      0/45.17      0/39.67      0/47.85     |1/45.04      0/44.73      3/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         7.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |1/34 (3%)    0/33 (0%)    3/35 (9%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.505N     P=0.506N     P=0.315      P=0.506N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.508N     P=0.501N     P=0.288      P=0.504N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.505N     P=0.501N     P=0.291      P=0.502N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.511N     P=0.503N     P=0.289      P=0.506N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.505N     (e)          P=0.315      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.501N     P=0.500N     P=0.301      P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.265N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |25/50 (50%)  27/50 (54%)  21/49 (43%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     2/44.52      2/45.17      2/39.67      1/47.85     |25/46.40     27/45.60     21/44.76     21/45.66     | 
|POLY-3 PERCENT (g) |     4.5%         4.4%         5.0%         2.1%        |53.9%        59.2%        46.9%        46.0%        | 
|TERMINAL (d)       |     1/29 (3%)    2/36 (6%)    2/27 (7%)    1/41 (2%)   |18/34 (53%)  22/33 (67%)  15/35 (43%)  16/33 (49%)  | 
|FIRST INCIDENCE    |     710          731 (T)      731 (T)      731 (T)     |649          675          470          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.283N     P=0.624N     P=0.657      P=0.396N    |P=0.199N     P=0.368      P=0.279N     P=0.339N     | 
|POLY 3             |     P=0.351N     P=0.689N     P=0.652      P=0.475N    |P=0.162N     P=0.378      P=0.323N     P=0.289N     | 
|POLY 1.5           |     P=0.361N     P=0.694      P=0.665      P=0.486N    |P=0.160N     P=0.395      P=0.320N     P=0.282N     | 
|POLY 6             |     P=0.336N     P=0.680N     P=0.636      P=0.459N    |P=0.164N     P=0.344      P=0.316N     P=0.303N     | 
|LOGISTIC REGRESSION|     P=0.311N     P=0.664N     P=0.628      P=0.444N    |P=0.183N     P=0.388      P=0.343N     P=0.302N     | 
|COCH-ARM / FISHERS |     P=0.373N     P=0.691N     P=0.691N     P=0.500N    |P=0.160N     P=0.421      P=0.305N     P=0.274N     | 
|ORDER RESTRICTED   |     P=0.415N     (e)          (e)          (e)         |P=0.239N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |25/50 (50%)  27/50 (54%)  21/49 (43%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     2/44.52      2/45.17      2/39.67      1/47.85     |25/46.40     27/45.60     21/44.76     21/45.66     | 
|POLY-3 PERCENT (g) |     4.5%         4.4%         5.0%         2.1%        |53.9%        59.2%        46.9%        46.0%        | 
|TERMINAL (d)       |     1/29 (3%)    2/36 (6%)    2/27 (7%)    1/41 (2%)   |18/34 (53%)  22/33 (67%)  15/35 (43%)  16/33 (49%)  | 
|FIRST INCIDENCE    |     710          731 (T)      731 (T)      731 (T)     |649          675          470          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.283N     P=0.624N     P=0.657      P=0.396N    |P=0.199N     P=0.368      P=0.279N     P=0.339N     | 
|POLY 3             |     P=0.351N     P=0.689N     P=0.652      P=0.475N    |P=0.162N     P=0.378      P=0.323N     P=0.289N     | 
|POLY 1.5           |     P=0.361N     P=0.694      P=0.665      P=0.486N    |P=0.160N     P=0.395      P=0.320N     P=0.282N     | 
|POLY 6             |     P=0.336N     P=0.680N     P=0.636      P=0.459N    |P=0.164N     P=0.344      P=0.316N     P=0.303N     | 
|LOGISTIC REGRESSION|     P=0.311N     P=0.664N     P=0.628      P=0.444N    |P=0.183N     P=0.388      P=0.343N     P=0.302N     | 
|COCH-ARM / FISHERS |     P=0.373N     P=0.691N     P=0.691N     P=0.500N    |P=0.160N     P=0.421      P=0.305N     P=0.274N     | 
|ORDER RESTRICTED   |     P=0.415N     (e)          (e)          (e)         |P=0.239N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |26/50 (52%)  27/50 (54%)  23/49 (47%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     2/44.52      2/45.17      2/39.67      1/47.85     |26/46.40     27/45.60     23/44.76     21/45.66     | 
|POLY-3 PERCENT (g) |     4.5%         4.4%         5.0%         2.1%        |56.0%        59.2%        51.4%        46.0%        | 
|TERMINAL (d)       |     1/29 (3%)    2/36 (6%)    2/27 (7%)    1/41 (2%)   |19/34 (56%)  22/33 (67%)  17/35 (49%)  16/33 (49%)  | 
|FIRST INCIDENCE    |     710          731 (T)      731 (T)      731 (T)     |649          675          470          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.283N     P=0.624N     P=0.657      P=0.396N    |P=0.169N     P=0.439      P=0.340N     P=0.275N     | 
|POLY 3             |     P=0.351N     P=0.689N     P=0.652      P=0.475N    |P=0.133N     P=0.461      P=0.406N     P=0.222N     | 
|POLY 1.5           |     P=0.361N     P=0.694      P=0.665      P=0.486N    |P=0.132N     P=0.476      P=0.401N     P=0.217N     | 
|POLY 6             |     P=0.336N     P=0.680N     P=0.636      P=0.459N    |P=0.133N     P=0.427      P=0.400N     P=0.232N     | 
|LOGISTIC REGRESSION|     P=0.311N     P=0.664N     P=0.628      P=0.444N    |P=0.154N     P=0.470      P=0.430N     P=0.236N     | 
|COCH-ARM / FISHERS |     P=0.373N     P=0.691N     P=0.691N     P=0.500N    |P=0.133N     P=0.500      P=0.381N     P=0.212N     | 
|ORDER RESTRICTED   |     P=0.415N     (e)          (e)          (e)         |P=0.198N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.52      0/45.17      2/40.46      0/47.85     |0/45.04      1/44.73      1/43.34      0/44.16      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         4.9%         0.0%        |0.0%         2.2%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |0/34 (0%)    1/33 (3%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     710          ---          535          ---         |---          735 (T)      632          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.438N     P=0.478N     P=0.443      P=0.458N    |P=0.598N     P=0.494      P=0.486      (e)          | 
|POLY 3             |     P=0.439N     P=0.497N     P=0.467      P=0.486N    |P=0.600N     P=0.499      P=0.492      (e)          | 
|POLY 1.5           |     P=0.448N     P=0.500N     P=0.476      P=0.492N    |P=0.598N     P=0.499      P=0.493      (e)          | 
|POLY 6             |     P=0.429N     P=0.492N     P=0.456      P=0.476N    |P=0.602N     P=0.497      P=0.494      (e)          | 
|LOGISTIC REGRESSION|     P=0.476N     P=0.498N     P=0.553      P=0.498N    |P=0.593N     P=0.494      P=0.510      (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.500N     P=0.500      P=0.500N    |P=0.595N     P=0.500      P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.301N     (e)          (e)          (e)         |P=0.396      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    2/48 (4%)    0/46 (0%)    0/42 (0%)   |0/47 (0%)    0/48 (0%)    0/46 (0%)    0/46 (0%)    | 
|POLY-3 RATE (b)    |     0/41.75      2/43.75      0/36.37      0/40.10     |0/42.43      0/43.29      0/40.57      0/41.76      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/28 (0%)    1/35 (3%)    0/24 (0%)    0/34 (0%)   |0/32 (0%)    0/32 (0%)    0/33 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          682          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.387N     P=0.270      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.421N     P=0.248      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.427N     P=0.243      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.410N     P=0.255      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.423N     P=0.243      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.428N     P=0.253      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.264N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  10/50 (20%)  10/50 (20%)  8/50 (16%)  |19/50 (38%)  18/50 (36%)  15/49 (31%)  17/50 (34%)  | 
|POLY-3 RATE (b)    |     13/45.01     10/45.75     10/42.45     8/48.01     |19/46.79     18/45.62     15/43.94     17/46.59     | 
|POLY-3 PERCENT (g) |     28.9%        21.9%        23.6%        16.7%       |40.6%        39.5%        34.1%        36.5%        | 
|TERMINAL (d)       |     10/29 (35%)  7/36 (19%)   3/27 (11%)   7/41 (17%)  |14/34 (41%)  14/33 (42%)  11/35 (31%)  10/33 (30%)  | 
|FIRST INCIDENCE    |     631          591          488          691         |557          626          610          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.064N     P=0.169N     P=0.440N     P=0.037N*   |P=0.393N     P=0.538N     P=0.265N     P=0.467N     | 
|POLY 3             |     P=0.115N     P=0.299N     P=0.373N     P=0.122N    |P=0.354N     P=0.540N     P=0.337N     P=0.422N     | 
|POLY 1.5           |     P=0.130N     P=0.315N     P=0.363N     P=0.139N    |P=0.357N     P=0.525N     P=0.322N     P=0.422N     | 
|POLY 6             |     P=0.097N     P=0.273N     P=0.379N     P=0.100N    |P=0.343N     P=0.564N     P=0.342N     P=0.417N     | 
|LOGISTIC REGRESSION|     P=0.138N     P=0.283N     P=0.354N     P=0.090N    |P=0.372N     P=0.508N     P=0.310N     P=0.420N     | 
|COCH-ARM / FISHERS |     P=0.150N     P=0.318N     P=0.318N     P=0.163N    |P=0.356N     P=0.500N     P=0.287N     P=0.418N     | 
|ORDER RESTRICTED   |     P=0.116N     (e)          (e)          (e)         |P=0.469N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           | 
|     Trichoepithelioma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.44      3/45.47      0/39.67      0/47.85     |0/45.04      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         6.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    2/36 (6%)    0/27 (0%)    0/41 (0%)   |0/34 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          648          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.270N     P=0.152      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.294N     P=0.123      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.303N     P=0.120      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.277N     P=0.129      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.306N     P=0.121      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.311N     P=0.121      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.154N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.93      4/45.47      0/39.67      0/47.85     |0/45.04      1/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     2.2%         8.8%         0.0%         0.0%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    3/36 (8%)    0/27 (0%)    0/41 (0%)   |0/34 (0%)    1/33 (3%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     586          648          ---          ---         |---          735 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.104N     P=0.228      P=0.527N     P=0.492N    |P=0.570N     P=0.494      (e)          (e)          | 
|POLY 3             |     P=0.115N     P=0.182      P=0.525N     P=0.487N    |P=0.570N     P=0.499      (e)          (e)          | 
|POLY 1.5           |     P=0.120N     P=0.178      P=0.517N     P=0.493N    |P=0.569N     P=0.499      (e)          (e)          | 
|POLY 6             |     P=0.108N     P=0.190      P=0.534N     P=0.479N    |P=0.571N     P=0.497      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.125N     P=0.182      P=0.420N     P=0.620N    |(e)          P=0.494      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.181      P=0.500N     P=0.500N    |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.071N     (e)          (e)          (e)         |P=0.383N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   4/50 (8%)    0/50 (0%)   |0/50 (0%)    3/50 (6%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/45.06      6/45.47      4/39.81      0/47.85     |0/45.04      3/45.20      0/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     8.9%         13.2%        10.1%        0.0%        |0.0%         6.6%         0.0%         2.3%         | 
|TERMINAL (d)       |     2/29 (7%)    5/36 (14%)   3/27 (11%)   0/41 (0%)   |0/34 (0%)    2/33 (6%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     586          648          695          ---         |---          597          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.022N*    P=0.472      P=0.567      P=0.041N*   |P=0.626      P=0.121      (e)          P=0.494      | 
|POLY 3             |     P=0.029N*    P=0.375      P=0.574      P=0.053N    |P=0.626      P=0.119      (e)          P=0.496      | 
|POLY 1.5           |     P=0.032N*    P=0.368      P=0.596      P=0.056N    |P=0.628      P=0.119      (e)          P=0.498      | 
|POLY 6             |     P=0.025N*    P=0.389      P=0.546      P=0.049N*   |P=0.623      P=0.119      (e)          P=0.494      | 
|LOGISTIC REGRESSION|     P=0.034N*    P=0.370      P=0.582      P=0.079N    |P=0.632      P=0.121      (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.037N*    P=0.370      P=0.643N     P=0.059N    |P=0.633      P=0.121      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.028N*    (e)          (e)          (e)         |P=0.263      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.52      1/45.17      2/39.87      4/48.20     |0/45.04      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         5.0%         8.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    1/36 (3%)    1/27 (4%)    2/41 (5%)   |0/34 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     711          731 (T)      676          672         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      P=0.720N     P=0.451      P=0.268     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.083      P=0.757N     P=0.462      P=0.204     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.078      P=0.760      P=0.473      P=0.193     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.091      P=0.752N     P=0.448      P=0.222     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.083      P=0.751N     P=0.457      P=0.174     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.072      P=0.753N     P=0.500      P=0.181     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.115      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    3/50 (6%)    7/50 (14%)  |0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/45.39      3/45.36      3/39.95      7/48.89     |0/45.04      0/44.73      1/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     11.0%        6.6%         7.5%         14.3%       |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    2/36 (6%)    1/27 (4%)    4/41 (10%)  |0/34 (0%)    0/33 (0%)    1/35 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     603          682          676          499         |---          ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.349      P=0.303N     P=0.447N     P=0.538     |P=0.693      (e)          P=0.506      (e)          | 
|POLY 3             |     P=0.254      P=0.357N     P=0.428N     P=0.432     |P=0.687      (e)          P=0.491      (e)          | 
|POLY 1.5           |     P=0.242      P=0.361N     P=0.404N     P=0.410     |P=0.690      (e)          P=0.492      (e)          | 
|POLY 6             |     P=0.272      P=0.348N     P=0.458N     P=0.463     |P=0.684      (e)          P=0.491      (e)          | 
|LOGISTIC REGRESSION|     P=0.224      P=0.354N     P=0.381N     P=0.239     |(e)          (e)          P=0.506      (e)          | 
|COCH-ARM / FISHERS |     P=0.226      P=0.357N     P=0.357N     P=0.380     |P=0.694      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.261      (e)          (e)          (e)         |P=0.372      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.31      1/45.17      0/39.67      1/47.85     |0/45.04      0/44.73      1/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     8.8%         2.2%         0.0%         2.1%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    1/36 (3%)    0/27 (0%)    1/41 (2%)   |0/34 (0%)    0/33 (0%)    1/35 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     603          731 (T)      ---          731 (T)     |---          ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.085N     P=0.157N     P=0.094N     P=0.127N    |P=0.693      (e)          P=0.506      (e)          | 
|POLY 3             |     P=0.103N     P=0.179N     P=0.079N     P=0.163N    |P=0.687      (e)          P=0.491      (e)          | 
|POLY 1.5           |     P=0.103N     P=0.182N     P=0.072N     P=0.170N    |P=0.690      (e)          P=0.492      (e)          | 
|POLY 6             |     P=0.102N     P=0.175N     P=0.088N     P=0.153N    |P=0.684      (e)          P=0.491      (e)          | 
|LOGISTIC REGRESSION|     P=0.103N     P=0.174N     P=0.054N     P=0.232N    |(e)          (e)          P=0.506      (e)          | 
|COCH-ARM / FISHERS |     P=0.104N     P=0.181N     P=0.059N     P=0.181N    |P=0.694      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.023N*    (e)          (e)          (e)         |P=0.372      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.31      3/45.36      1/39.74      3/48.53     |0/45.04      0/44.73      1/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     8.8%         6.6%         2.5%         6.2%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    2/36 (6%)    0/27 (0%)    2/41 (5%)   |0/34 (0%)    0/33 (0%)    1/35 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     603          682          713          499         |---          ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.315N     P=0.444N     P=0.238N     P=0.395N    |P=0.693      (e)          P=0.506      (e)          | 
|POLY 3             |     P=0.382N     P=0.499N     P=0.221N     P=0.463N    |P=0.687      (e)          P=0.491      (e)          | 
|POLY 1.5           |     P=0.390N     P=0.504N     P=0.206N     P=0.478N    |P=0.690      (e)          P=0.492      (e)          | 
|POLY 6             |     P=0.372N     P=0.491N     P=0.240N     P=0.442N    |P=0.684      (e)          P=0.491      (e)          | 
|LOGISTIC REGRESSION|     P=0.405N     P=0.497N     P=0.176N     P=0.649     |(e)          (e)          P=0.506      (e)          | 
|COCH-ARM / FISHERS |     P=0.397N     P=0.500N     P=0.181N     P=0.500N    |P=0.694      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.299N     (e)          (e)          (e)         |P=0.372      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrous Histiocytoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.44      2/45.36      1/39.74      1/47.85     |0/45.04      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.5%         2.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    1/36 (3%)    0/27 (0%)    1/41 (2%)   |0/34 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          682          713          731 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      P=0.269      P=0.486      P=0.569     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.533      P=0.242      P=0.478      P=0.515     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.518      P=0.238      P=0.485      P=0.508     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.556      P=0.249      P=0.470      P=0.524     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.522      P=0.238      P=0.470      P=0.569     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500      P=0.247      P=0.500      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.256      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/44.58      3/45.17      3/39.81      0/47.85     |0/45.04      2/45.20      0/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     6.7%         6.6%         7.5%         0.0%        |0.0%         4.4%         0.0%         2.3%         | 
|TERMINAL (d)       |     2/29 (7%)    3/36 (8%)    2/27 (7%)    0/41 (0%)   |0/34 (0%)    1/33 (3%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     696          731 (T)      695          ---         |---          597          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061N     P=0.577N     P=0.594      P=0.078N    |P=0.531      P=0.239      (e)          P=0.494      | 
|POLY 3             |     P=0.079N     P=0.656N     P=0.609      P=0.107N    |P=0.531      P=0.238      (e)          P=0.496      | 
|POLY 1.5           |     P=0.085N     P=0.662      P=0.626      P=0.112N    |P=0.534      P=0.237      (e)          P=0.498      | 
|POLY 6             |     P=0.071N     P=0.646N     P=0.590      P=0.099N    |P=0.529      P=0.238      (e)          P=0.494      | 
|LOGISTIC REGRESSION|     P=0.076N     P=0.626N     P=0.581      P=0.100N    |P=0.540      P=0.242      (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.092N     P=0.661N     P=0.661N     P=0.121N    |P=0.539      P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.092N     (e)          (e)          (e)         |P=0.321      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    4/50 (8%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/44.58      3/45.17      4/39.81      0/47.85     |0/45.04      2/45.20      0/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     6.7%         6.6%         10.1%        0.0%        |0.0%         4.4%         0.0%         2.3%         | 
|TERMINAL (d)       |     2/29 (7%)    3/36 (8%)    3/27 (11%)   0/41 (0%)   |0/34 (0%)    1/33 (3%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     696          731 (T)      695          ---         |---          597          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.073N     P=0.577N     P=0.428      P=0.078N    |P=0.531      P=0.239      (e)          P=0.494      | 
|POLY 3             |     P=0.094N     P=0.656N     P=0.438      P=0.107N    |P=0.531      P=0.238      (e)          P=0.496      | 
|POLY 1.5           |     P=0.102N     P=0.662      P=0.458      P=0.112N    |P=0.534      P=0.237      (e)          P=0.498      | 
|POLY 6             |     P=0.084N     P=0.646N     P=0.416      P=0.099N    |P=0.529      P=0.238      (e)          P=0.494      | 
|LOGISTIC REGRESSION|     P=0.091N     P=0.626N     P=0.401      P=0.100N    |P=0.540      P=0.242      (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.114N     P=0.661N     P=0.500      P=0.121N    |P=0.539      P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.074N     (e)          (e)          (e)         |P=0.321      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Trichoepithelioma                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.44      3/45.47      0/39.67      0/47.85     |0/45.04      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         6.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    2/36 (6%)    0/27 (0%)    0/41 (0%)   |0/34 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          648          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.270N     P=0.152      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.294N     P=0.123      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.303N     P=0.120      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.277N     P=0.129      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.306N     P=0.121      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.311N     P=0.121      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.154N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  47/49 (96%)  42/50 (84%)  50/50 (100%)|                                                    | 
|POLY-3 RATE (b)    |     45/49.43     47/47.18     42/45.94     50/50.00    |                                                    | 
|POLY-3 PERCENT (g) |     91.0%        99.6%        91.4%        100.0%      |                                                    | 
|TERMINAL (d)       |     27/29 (93%)  36/36 (100%) 26/27 (96%)  41/41 (100%)|                                                    | 
|FIRST INCIDENCE    |     508          591          506          499         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.114N     P=0.203N     P=0.457      P=0.080N    |                                                    | 
|POLY 3             |     P=0.054      P=0.053      P=0.625      P=0.037 *   |                                                    | 
|POLY 1.5           |     P=0.059      P=0.071      P=0.567N     P=0.033 *   |                                                    | 
|POLY 6             |     P=0.053      P=0.054      P=0.537      P=0.045 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.107      P=0.127      P=0.582N     P=0.036 *   |                                                    | 
|COCH-ARM / FISHERS |     P=0.093      P=0.226      P=0.277N     P=0.028 *   |                                                    | 
|ORDER RESTRICTED   |     P=0.009 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    10/50 (20%)  3/50 (6%)    10/50 (20%) |5/50 (10%)   3/49 (6%)    4/49 (8%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     4/44.44      10/45.74     3/40.17      10/48.06    |5/45.15      3/44.88      4/42.98      5/44.16      | 
|POLY-3 PERCENT (g) |     9.0%         21.9%        7.5%         20.8%       |11.1%        6.7%         9.3%         11.3%        | 
|TERMINAL (d)       |     4/29 (14%)   6/36 (17%)   2/27 (7%)    9/41 (22%)  |4/34 (12%)   1/33 (3%)    4/35 (11%)   5/33 (15%)   | 
|FIRST INCIDENCE    |     731 (T)      648          577          675         |708          626          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.300      P=0.146      P=0.542N     P=0.212     |P=0.472      P=0.375N     P=0.484N     P=0.612      | 
|POLY 3             |     P=0.164      P=0.079      P=0.555N     P=0.097     |P=0.466      P=0.360N     P=0.531N     P=0.617      | 
|POLY 1.5           |     P=0.150      P=0.074      P=0.539N     P=0.086     |P=0.474      P=0.364N     P=0.526N     P=0.622      | 
|POLY 6             |     P=0.189      P=0.091      P=0.573N     P=0.116     |P=0.457      P=0.355N     P=0.531N     P=0.610      | 
|LOGISTIC REGRESSION|     P=0.190      P=0.087      P=0.574N     P=0.144     |P=0.466      P=0.367N     P=0.506N     P=0.615      | 
|COCH-ARM / FISHERS |     P=0.139      P=0.074      P=0.500N     P=0.074     |P=0.486      P=0.369N     P=0.513N     P=0.630N     | 
|ORDER RESTRICTED   |     P=0.078      (e)          (e)          (e)         |P=0.546      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |3/50 (6%)    0/49 (0%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.53      1/45.17      1/39.67      1/48.10     |3/45.09      0/44.29      3/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         2.5%         2.1%        |6.7%         0.0%         7.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    1/36 (3%)    1/27 (4%)    0/41 (0%)   |2/34 (6%)    0/33 (0%)    3/35 (9%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     709          731 (T)      731 (T)      666         |723          ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.567N     P=0.730N     P=0.724      P=0.723N    |P=0.166N     P=0.132N     P=0.651N     P=0.128N     | 
|POLY 3             |     P=0.619N     P=0.758N     P=0.734      P=0.743N    |P=0.167N     P=0.122N     P=0.640      P=0.122N     | 
|POLY 1.5           |     P=0.626N     P=0.760      P=0.743      P=0.751N    |P=0.165N     P=0.122N     P=0.643      P=0.121N     | 
|POLY 6             |     P=0.609N     P=0.752N     P=0.724      P=0.731N    |P=0.169N     P=0.122N     P=0.641      P=0.124N     | 
|LOGISTIC REGRESSION|     P=0.618N     P=0.753N     P=0.723      P=0.734     |P=0.165N     P=0.125N     P=0.665N     P=0.125N     | 
|COCH-ARM / FISHERS |     P=0.634      P=0.753N     P=0.753N     P=0.753N    |P=0.163N     P=0.125N     P=0.651      P=0.121N     | 
|ORDER RESTRICTED   |     P=0.711N     (e)          (e)          (e)         |P=0.057N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   11/50 (22%)  4/50 (8%)    11/50 (22%) |8/50 (16%)   3/49 (6%)    7/49 (14%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     5/44.53      11/45.74     4/40.17      11/48.31    |8/45.20      3/44.88      7/42.98      5/44.16      | 
|POLY-3 PERCENT (g) |     11.2%        24.1%        10.0%        22.8%       |17.7%        6.7%         16.3%        11.3%        | 
|TERMINAL (d)       |     4/29 (14%)   7/36 (19%)   3/27 (11%)   9/41 (22%)  |6/34 (18%)   1/33 (3%)    7/35 (20%)   5/33 (15%)   | 
|FIRST INCIDENCE    |     709          648          577          666         |708          626          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.333      P=0.170      P=0.560N     P=0.244     |P=0.380N     P=0.118N     P=0.479N     P=0.296N     | 
|POLY 3             |     P=0.185      P=0.092      P=0.564N     P=0.115     |P=0.388N     P=0.100N     P=0.542N     P=0.290N     | 
|POLY 1.5           |     P=0.168      P=0.086      P=0.545N     P=0.101     |P=0.378N     P=0.103N     P=0.535N     P=0.285N     | 
|POLY 6             |     P=0.216      P=0.104      P=0.587N     P=0.139     |P=0.398N     P=0.097N     P=0.544N     P=0.297N     | 
|LOGISTIC REGRESSION|     P=0.206      P=0.101      P=0.591N     P=0.135     |P=0.388N     P=0.106N     P=0.506N     P=0.290N     | 
|COCH-ARM / FISHERS |     P=0.153      P=0.086      P=0.500N     P=0.086     |P=0.365N     P=0.106N     P=0.517N     P=0.277N     | 
|ORDER RESTRICTED   |     P=0.100      (e)          (e)          (e)         |P=0.292N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.89      1/45.17      0/39.67      0/47.85     |0/45.04      0/44.29      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     4.5%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    1/36 (3%)    0/27 (0%)    0/41 (0%)   |0/34 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     631          731 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.092N     P=0.464N     P=0.295N     P=0.207N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.101N     P=0.498N     P=0.266N     P=0.223N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.102N     P=0.502N     P=0.256N     P=0.229N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.101N     P=0.491N     P=0.278N     P=0.215N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.100N     P=0.498N     P=0.224N     P=0.290N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.066N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |7/50 (14%)   8/50 (16%)   8/49 (16%)   12/50 (24%)  | 
|POLY-3 RATE (b)    |                                                        |7/45.35      8/45.44      8/43.68      12/44.96     | 
|POLY-3 PERCENT (g) |                                                        |15.4%        17.6%        18.3%        26.7%        | 
|TERMINAL (d)       |                                                        |6/34 (18%)   6/33 (18%)   6/35 (17%)   10/33 (30%)  | 
|FIRST INCIDENCE    |                                                        |649          597          543          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.101      P=0.481      P=0.511      P=0.136      | 
|POLY 3             |                                                        |P=0.101      P=0.502      P=0.468      P=0.145      | 
|POLY 1.5           |                                                        |P=0.104      P=0.500      P=0.471      P=0.148      | 
|POLY 6             |                                                        |P=0.099      P=0.501      P=0.473      P=0.141      | 
|LOGISTIC REGRESSION|                                                        |P=0.101      P=0.495      P=0.465      P=0.141      | 
|COCH-ARM / FISHERS |                                                        |P=0.109      P=0.500      P=0.483      P=0.154      | 
|ORDER RESTRICTED   |                                                        |P=0.135      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  15/50 (30%)  21/50 (42%)  9/50 (18%)  |9/50 (18%)   8/50 (16%)   7/49 (14%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     22/47.65     15/47.08     21/45.35     9/48.49     |9/47.27      8/46.60      7/44.76      9/46.19      | 
|POLY-3 PERCENT (g) |     46.2%        31.9%        46.3%        18.6%       |19.0%        17.2%        15.6%        19.5%        | 
|TERMINAL (d)       |     10/29 (35%)  8/36 (22%)   7/27 (26%)   6/41 (15%)  |2/34 (6%)    2/33 (6%)    2/35 (6%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     524          593          506          633         |203          561          459          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006N**   P=0.068N     P=0.453      P<0.001N**  |P=0.509      P=0.521N     P=0.422N     P=0.568      | 
|POLY 3             |     P=0.006N**   P=0.110N     P=0.578      P=0.003N**  |P=0.516      P=0.513N     P=0.439N     P=0.582      | 
|POLY 1.5           |     P=0.006N**   P=0.114N     P=0.576N     P=0.003N**  |P=0.520      P=0.513N     P=0.434N     P=0.585      | 
|POLY 6             |     P=0.005N**   P=0.100N     P=0.580      P=0.002N**  |P=0.515      P=0.515N     P=0.437N     P=0.580      | 
|LOGISTIC REGRESSION|     P=0.011N*    P=0.105N     P=0.440N     P=0.010N*   |P=0.544N     P=0.484N     P=0.350N     P=0.574N     | 
|COCH-ARM / FISHERS |     P=0.009N**   P=0.107N     P=0.500N     P=0.004N**  |P=0.536      P=0.500N     P=0.410N     P=0.602N     | 
|ORDER RESTRICTED   |     P=0.002N**   (e)          (e)          (e)         |P=0.609      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.60      5/45.39      0/39.67      1/47.85     |0/45.04      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     6.7%         11.0%        0.0%         2.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/29 (7%)    4/36 (11%)   0/27 (0%)    1/41 (2%)   |0/34 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     690          672          ---          731 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.062N     P=0.452      P=0.149N     P=0.209N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.084N     P=0.366      P=0.141N     P=0.281N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.088N     P=0.357      P=0.134N     P=0.292N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.077N     P=0.381      P=0.150N     P=0.265N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.079N     P=0.378      P=0.150N     P=0.261N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.092N     P=0.357      P=0.121N     P=0.309N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.059N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.60      5/45.39      0/39.67      1/47.85     |0/45.04      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     6.7%         11.0%        0.0%         2.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/29 (7%)    4/36 (11%)   0/27 (0%)    1/41 (2%)   |0/34 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     690          672          ---          731 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.062N     P=0.452      P=0.149N     P=0.209N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.084N     P=0.366      P=0.141N     P=0.281N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.088N     P=0.357      P=0.134N     P=0.292N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.077N     P=0.381      P=0.150N     P=0.265N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.079N     P=0.378      P=0.150N     P=0.261N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.092N     P=0.357      P=0.121N     P=0.309N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.059N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 48/50 (96%)  48/50 (96%)  50/50 (100%)|39/50 (78%)  37/50 (74%)  38/49 (78%)  38/50 (76%)  | 
|POLY-3 RATE (b)    |     50/50.00     48/48.18     48/48.02     50/50.00    |39/47.85     37/47.12     38/46.15     38/47.77     | 
|POLY-3 PERCENT (g) |     100.0%       99.6%        100.0%       100.0%      |81.5%        78.5%        82.4%        79.6%        | 
|TERMINAL (d)       |     29/29 (100%) 36/36 (100%) 27/27 (100%) 41/41 (100%)|28/34 (82%)  27/33 (82%)  29/35 (83%)  26/33 (79%)  | 
|FIRST INCIDENCE    |     508          591          488          499         |557          597          470          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029N*    P=0.059N     P=0.352      (e)         |P=0.505      P=0.504N     P=0.475N     P=0.555      | 
|POLY 3             |     P=1.000      P=1.000N     P=1.000N     (e)         |P=0.502N     P=0.455N     P=0.566      P=0.506N     | 
|POLY 1.5           |     P=0.842      P=0.864N     P=1.000N     (e)         |P=0.508N     P=0.440N     P=0.578      P=0.507N     | 
|POLY 6             |     P=1.000      P=1.000N     P=1.000N     (e)         |P=0.484N     P=0.488N     P=0.575      P=0.503N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.530      P=0.414N     P=0.534      P=0.539N     | 
|COCH-ARM / FISHERS |     P=0.500      P=0.247N     P=0.247N     (e)         |P=0.509N     P=0.408N     P=0.574N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.353      (e)          (e)          (e)         |P=0.623N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/10/02                           EXPERIMENT: 56111 TEST: 03                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   TRANS-CINNAMALDEHYDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/50 (60%)  27/50 (54%)  27/50 (54%)  19/50 (38%) |21/50 (42%)  14/50 (28%)  16/49 (33%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     30/48.60     27/48.54     27/46.31     19/49.63    |21/48.39     14/47.45     16/45.45     13/46.64     | 
|POLY-3 PERCENT (g) |     61.7%        55.6%        58.3%        38.3%       |43.4%        29.5%        35.2%        27.9%        | 
|TERMINAL (d)       |     14/29 (48%)  15/36 (42%)  10/27 (37%)  13/41 (32%) |10/34 (29%)  5/33 (15%)   10/35 (29%)  4/33 (12%)   | 
|FIRST INCIDENCE    |     524          404          506          499         |203          561          459          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008N**   P=0.188N     P=0.523      P=0.004N**  |P=0.142N     P=0.160N     P=0.244N     P=0.123N     | 
|POLY 3             |     P=0.011N*    P=0.343N     P=0.448N     P=0.015N*   |P=0.110N     P=0.114N     P=0.274N     P=0.084N     | 
|POLY 1.5           |     P=0.012N*    P=0.357N     P=0.434N     P=0.017N*   |P=0.105N     P=0.114N     P=0.262N     P=0.080N     | 
|POLY 6             |     P=0.009N**   P=0.319N     P=0.450N     P=0.013N*   |P=0.116N     P=0.116N     P=0.285N     P=0.090N     | 
|LOGISTIC REGRESSION|     P=0.021N*    P=0.342N     P=0.316N     P=0.067N    |P=0.085N     P=0.096N     P=0.202N     P=0.059N     | 
|COCH-ARM / FISHERS |     P=0.017N*    P=0.343N     P=0.343N     P=0.022N*   |P=0.093N     P=0.104N     P=0.226N     P=0.069N     | 
|ORDER RESTRICTED   |     P=0.011N*    (e)          (e)          (e)         |P=0.080N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 49/50 (98%)  48/50 (96%)  50/50 (100%)|45/50 (90%)  42/50 (84%)  44/49 (90%)  42/50 (84%)  | 
|POLY-3 RATE (b)    |     50/50.00     49/49.01     48/48.02     50/50.00    |45/50.00     42/48.93     44/48.01     42/48.81     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |90.0%        85.8%        91.6%        86.1%        | 
|TERMINAL (d)       |     29/29 (100%) 36/36 (100%) 27/27 (100%) 41/41 (100%)|29/34 (85%)  27/33 (82%)  31/35 (89%)  27/33 (82%)  | 
|FIRST INCIDENCE    |     508          404          488          499         |203          561          459          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.026N*    P=0.087N     P=0.352      (e)         |P=0.453N     P=0.444N     P=0.487N     P=0.460N     | 
|POLY 3             |     P=1.000      P=1.000N     P=1.000N     (e)         |P=0.401N     P=0.372N     P=0.527      P=0.384N     | 
|POLY 1.5           |     P=1.000      P=1.000N     P=1.000N     (e)         |P=0.381N     P=0.365N     P=0.540      P=0.365N     | 
|POLY 6             |     P=1.000      P=1.000N     P=1.000N     (e)         |P=0.419N     P=0.378N     P=0.525      P=0.402N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.320N     P=0.281N     P=0.631      P=0.281N     | 
|COCH-ARM / FISHERS |     P=0.616      P=0.500N     P=0.247N     (e)         |P=0.308N     P=0.277N     P=0.617N     P=0.277N     | 
|ORDER RESTRICTED   |     P=0.353      (e)          (e)          (e)         |P=0.427N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).