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TDMS Study 56111-03 Pathology Tables

NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01
Route: DOSED FEED                                                                                                 Time: 10:41:09

                                                            FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  14371-10-9

       Lock Date:  06/01/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|             
                                           | 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                                                                  |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X     X     X  X     X  X  X     X  X  X  X  X|             
      Clear Cell Focus                     |             X                                                            |             
      Fibrosis                             |                                                                   3      |             
      Hematopoietic Cell Proliferation     | 1                    1                                                   |             
      Hepatodiaphragmatic Nodule           |                                  X                                       |             
      Infarct                              |                                                                   4      |             
      Inflammation, Chronic Active         | 1  3  1  2  2  2  3  1  2  2     2     2  1  1  2  1  1     2  1  3  2  2|             
      Mixed Cell Focus                     |    X  X  X  X     X  X  X  X           X     X  X     X     X        X   |             
      Necrosis                             |       1        2              2                                          |             
      Bile Duct, Hyperplasia               | 1        1  1           1  1  2  1           1  1           1     2  1   |             
      Hepatocyte, Degeneration, Cystic     |                                                       2                  |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|       1  1  1  1  1     1  1  3  1     1  1  1  1     1           3  1  1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +           +                 +     +                       +     +   |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Mineralization                  |                2                 2     2                             2   |             
      Fat, Necrosis                        |                4                 4     4                       4     4   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|             
                                           | 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +                 +  +              +     +              +            |             
      Foreign Body                         | X  X                 X  X              X                    X            |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           | 4                    2  1                    2                           |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                         1                                   1            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1                 1     2                                   2     1   |             
      Basophilic Focus                     |             X     X     X                       X  X           2         |             
      Inflammation, Chronic Active         |                         1                                                |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                           1                              |             
      Epithelium, Hyperplasia              |                                                                          |             
      Epithelium, Ulcer                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Epithelium, Erosion                  |                                                          2               |             
      Epithelium, Hyperplasia              |                                                                          |             
      Glands, Ectasia                      | 1  1  1  1     1  1  2  1  1  1  1        1  1     1        1     1  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     1  2        2  2  1  1  1  2        1  1           1  1     2  2|             
      Mineralization                       |                      1                                                   |             
      Atrium, Thrombosis                   |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|             
                                           | 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Accessory Adrenal Cortical Nodule    |             2                                                            |             
      Hematopoietic Cell Proliferation     | 1                    1                                                   |             
      Hyperplasia                          |             1        1           2                 2                     |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |             2        3  1     3        2  1  2     1           2  2  3  3|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2           2        2                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2                                                              2         |             
      Pars Distalis, Cyst                  |    2              2  2  2  2  2        2     3  2        1  1  1  2     1|             
      Pars Distalis, Hyperplasia           | 2        2  2        2  2  2  2        3     3     2                 3  2|             
      Pars Intermedia, Angiectasis         |                         2                                                |             
      Pars Intermedia, Cyst                | 2                                                                        |             
      Pars Intermedia, Hyperplasia         |                         2                                                |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Thymus                       |                                        2                                 |             
      C-Cell, Hyperplasia                  | 1           1  2  1  1     1     2        1  1  1                       2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                    2           4     2  3  2|             
      Inflammation, Chronic Active         | 3        2                 1                    1                       2|             
      Mineralization                       |                                                                          |             
      Duct, Cyst                           |                            2                    2           3        4  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|             
                                           | 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 |                                        4                                 |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    3                                                                 2   |             
      Metaplasia, Squamous                 |                                                                          |             
      Cervix, Cyst, Squamous               |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  4              3  4        4     4        4     3           3  3      |             
      Myelofibrosis                        |                               2                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +     +  +  +              +  +  +      |             
      Deep Cervical, Ectasia               |                                                                   2      |             
      Lumbar, Ectasia                      |    4                                                                     |             
      Mediastinal, Ectasia                 |          2     2  2     2  2     2     2  2  2              2  2         |             
      Mediastinal, Hyperplasia, Lymphoid   |          2  2  2  2  4  2  2     2     3  3  2              3  2         |             
      Mediastinal, Pigmentation            |                                           2                              |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                            2      |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4                    4                       3                    2      |             
      Hyperplasia, Lymphoid                |                                  3                                   4   |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +|             
      Ectopic Parathyroid Gland            |                                                          2               |             
      Inflammation, Chronic Active         |                      4                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|             
                                           | 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                4  4              4                                       |             
      Hyperplasia, Cystic                  | 4  2  2  2  2  3  1  4     2  4  2  2  2     3  2  3  3     2  2  3  2  3|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                3                                      3                  |             
      Hemorrhage                           |                                                          3               |             
      Hydrocephalus                        |                3                                      2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 3                                                                        |             
      Inflammation, Chronic Active         | 4        1     1  1     1  1                    1  1  1     1  2        1|             
      Metaplasia, Squamous                 | 2                                                                        |             
      Mineralization                       | 1     1  1     1  2  1  1     1  1  1  1  1  1  1  1  1     1  1  1  1  1|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1     1  1     1  1|             
      Alveolar Epithelium, Hyperplasia     | 4                                      1  2                              |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1     1  1     1  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              3                 2         |             
      Thrombosis                           |                               2     4                                    |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                           2  2                           |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|             
                                           | 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Cyst                                 |                                                                          |             
      Mineralization                       |          1     1  1  1  1  1     1           1     1  1        1  1  1   |             
      Nephropathy                          |    2     1  1  1  1  2  1  1  1  1        2  3  2  1        2  1     2  1|             
      Pigmentation                         |                      4                                                   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                           X                              |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     | X  X  X  X  X     X  X  X  X     X  X     X  X  X  X  X  X  X  X  X  X   |     42     |
      Clear Cell Focus                     |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                               1                                          |      3  1.0|
      Hepatodiaphragmatic Nodule           |          X                                   X     X                     |      4     |
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic Active         | 2  1  2  2  2     1  2  2  1  1     2  1  2  2  1  2  1  1  2  2  2  2   |     44  1.7|
      Mixed Cell Focus                     | X  X     X  X     X  X  X     X                    X  X  X           X   |     26     |
      Necrosis                             |                                                                   2     2|      5  1.8|
      Bile Duct, Hyperplasia               |                2        1  1        1                    1     1  2  1  2|     21  1.2|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      1  2.0|
      Hepatocyte, Hyperplasia              |                                                                   4      |      1  4.0|
      Hepatocyte, Vacuolization Cytoplasmic| 1  1     1  1        1  1  1           4  2     1     1  1           1  3|     31  1.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |       +                       +           +                    +        +|  11        |
      Fat, Inflammation, Chronic           |       3                                   3                    3        3|      4  3.0|
      Fat, Mineralization                  |       2                       2                                2        2|      8  2.0|
      Fat, Necrosis                        |       4                       4           4                    4         |      9  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +                       +                          +           +     +|  12        |
      Foreign Body                         |    X                       X                          X           X     X|     11     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                   2      |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |    1  2        2        1  2     2  1        2  1  1                     |     12  1.4|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    1                 1        2                             2  2     1   |     11  1.5|
      Basophilic Focus                     | X                                            X        X        X         |     10  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                         2|      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                                         3|      1  3.0|
      Epithelium, Ulcer                    |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    1                                                                     |      1  1.0|
      Epithelium, Erosion                  |                                                                         2|      2  2.0|
      Epithelium, Hyperplasia              |                                                       1                  |      1  1.0|
      Glands, Ectasia                      | 1  1  1  1  1  1  1  1  1  1  1  1  1        1  2  1  1        1  2  1  1|     39  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  2  2     2        2     2  1  1  2  2  1  2  2  2  2  2  2  2  2|     36  1.6|
      Mineralization                       |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hyperplasia                          |          2  2              2                       2  1  2               |     10  1.7|
      Hypertrophy                          |       2                                                                  |      1  2.0|
      Vacuolization Cytoplasmic            |    2        1  1           1                    2  1     1              4|     20  1.9|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
      Pars Distalis, Cyst                  | 2  2     1     1        2  2  2  2  1  2        2  2     2  2  1  2      |     30  1.8|
      Pars Distalis, Hyperplasia           | 2  2              4  2  2  2     1           2     3        2  2        2|     24  2.2|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                             1            |      2  1.5|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectopic Thymus                       |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 2  1  2  1     1  2     1           2        1  2  1     1               |     23  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       4                 2           2                          3        2|     11  2.5|
      Inflammation, Chronic Active         |       2           1  2  1                 4        3     1  1            |     13  1.8|
      Mineralization                       |                                                                         1|      1  1.0|
      Duct, Cyst                           |       2              2  2  2                       3        2            |     11  2.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |    3  4  2  4                 2           3  4     4                     |      9  3.3|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                                                          |      2  2.5|
      Metaplasia, Squamous                 |                                                             4            |      1  4.0|
      Cervix, Cyst, Squamous               |                                                                         3|      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                            2                                             |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                4              4        4                          4     4|     15  3.7|
      Myelofibrosis                        |                3                       4                                 |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +  +  +  +                 +  +        +     +        +  +  +|  30        |
      Deep Cervical, Ectasia               |                                                                          |      1  2.0|
      Lumbar, Ectasia                      |                                                                          |      1  4.0|
      Mediastinal, Ectasia                 |          2                                         2     2           2   |     15  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |          2  3        3                             2     2           2   |     19  2.4|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
      Ectasia                              |                                  2                                       |      1  2.0|
      Hyperplasia, Lymphoid                |                                  2                                       |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |       2              2        3              2     2     2  2  2         |     12  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
      Pigmentation                         |                                           3                              |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  43        |
      Ectopic Parathyroid Gland            |                      1  1                             1                  |      4  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                   4     4|      5  4.0|
      Hyperplasia, Cystic                  |    2  4  2  2  2  2  2  3  2     2  2     2  1     2  2  3  3  2  3  1  4|     43  2.4|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2  3.0|
      Hemorrhage                           |                                        2                                 |      2  2.5|
      Hydrocephalus                        |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 1  1  1  2  1     2  1  1  1  1  1           2  2  1  1  1  1  1     1   |     31  1.3|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1|     45  1.0|
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1        1  1  1  1  1  1  1  1  1   |     44  1.0|
      Alveolar Epithelium, Hyperplasia     |    2        2        2           2                    1  2  1  1     1   |     12  1.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1  1  1  1  1  1  1  1  1  1  1  1        1  2  1  1  1  1  1  1  1   |     44  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                           2                    2         |      4  2.3|
      Thrombosis                           |                                                                          |      2  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                  2           2                           |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Lens, Cataract                       |             4                                                            |      1  4.0|
      Retina, Degeneration                 |             4                                                            |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                   3      |      1  3.0|
      Cyst                                 | 2                                                                        |      1  2.0|
      Mineralization                       | 1  1        1  1  1        1     1  1  1  1     1  1     1  1  1  1     1|     30  1.0|
      Nephropathy                          | 1  1  2  1  2     1  1  1  1  3  1  1        1  1  2  1  2  1  1  1  1   |     39  1.4|
      Pigmentation                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|             
                                           | 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X           X     X                             X                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X     X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |             X                                                            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                     X  X                                 |             
      Inflammation, Chronic Active         | 2  2     2  1     1  1  2     1  2  2  2  2  1  2  1     2  2     2  2  2|             
      Mixed Cell Focus                     |             X     X     X  X  X        X  X  X  X                 X  X  X|             
      Necrosis                             |                            2                                             |             
      Pigmentation                         |                2                                                         |             
      Bile Duct, Hyperplasia               |    2     1  1  2        1  1  1              1  1     2  1     2        1|             
      Hepatocyte, Degeneration, Cystic     |                                                                          |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic| 1           1     1        2     1     1  1  1  1     2     1  4     1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                +     +        +                          +               |             
      Fat, Inflammation, Chronic           |                3     2        3                          2               |             
      Fat, Mineralization                  |                      1        2                          1               |             
      Fat, Necrosis                        |                4     4        4                          4               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                               +                 +                    +   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|             
                                           | 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Foreign Body                         |                               X                 X                    X   |             
      Gingival, Hyperplasia, Squamous      |                                                                          |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                               2                 2                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                            1  2  2              2  1                    1|             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Cyst                           |             2     2                                2        2            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1              1        2     1  1        1  1              2           2|             
      Basophilic Focus                     |                               X  X                       X        X      |             
      Inflammation, Chronic Active         |                                  1                                       |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Ectasia                      |    1  1  1  1     1  1  1     1  1     1     1        1  1     1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  2  2  1  2  2  2  2  2  2  2  1  2  2  2  2        2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                               2                          1               |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |    2     2  2     1  2        2  2        2  1     2     2               |             
      Hypertrophy                          |                                        2                          2      |             
      Necrosis                             |                            1                                             |             
      Vacuolization Cytoplasmic            |          1           2  1              1  2                    3  2     1|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|             
                                           | 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                 1                       2              1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |       2  1  2  2           2  1        2     1  2  1  2     3            |             
      Pars Distalis, Hyperplasia           |    1     2     2  2           2              2  2        2  2     2  2   |             
      Pars Intermedia, Hyperplasia         |             2                                                            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  1  1  2  1  1  2  1     2  1     2  1        1  1  1  1     1  1   |             
      Follicle, Cyst                       |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2           2        2        2                 2        2   |             
      Inflammation, Chronic Active         |          1  2                                                           1|             
      Duct, Cyst                           | 2        2  3           2        2        2                 2     3  2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Granulosa Cell, Hyperplasia          |                                                          2               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                 2                        |             
      Cervix, Epithelium, Hyperplasia      |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|             
                                           | 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  4        4     4     4                          4        4         |             
      Myelofibrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +     +  +  +  +  +        +     +     +  +  +  +        +  +      |             
      Mediastinal, Ectasia                 |             2     2  2  2              2     2  2     2           2      |             
      Mediastinal, Hyperplasia, Lymphoid   |             2     2  2  3        4     2     2  2  3  2           2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                      3        2                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                         2                 2           1                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  4                                       |             
      Cyst, Multiple                       |                                     4                                    |             
      Hyperplasia, Cystic                  | 2     2  2  2  3  2  2  2  2  2  2  3  2  2  3  2     2  3  2  3  2  2  2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Epidermis, Ulcer                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|             
                                           | 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     3                                    |             
      Hydrocephalus                        |                      2  3           2                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1     1  1     1     1     1  1     1  1  1  1  1     1  1     1  1  1|             
      Mineralization                       | 1  1  1     1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     |                               1        1  1                          1  4|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Focal, Squamous                 |                         3                                                |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            1                                             |             
      Thrombosis                           |       1                                                        4         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2                                      3                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|             
                                           | 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Cyst                                 |                                                    3                     |             
      Hydronephrosis                       |                                                                          |             
      Mineralization                       | 1     1  1  1     1  1  1  1  1  1  1     1  1  1     1     1     1  1  1|             
      Nephropathy                          | 1  1  1  1  1  2     1              1  2  1  1  1  1  2  2  1  1  2  1  2|             
      Pigmentation                         |                                        3                                 |             
      Pelvis, Inflammation, Suppurative    |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3|            |
                                           | 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X                                                                  |      5     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X                             X                 X               |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X     X  X  X  X  X     X  X  X  X  X  X  X     X|     44     |
      Clear Cell Focus                     |                                        X           X                     |      2     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                  1                                   1   |      2  1.0|
      Hepatodiaphragmatic Nodule           |             X           X                                   X            |      5     |
      Inflammation, Chronic Active         | 2  2  2  1  2  2  2  1  2     2  2  2  2  2     1  2  2     1  1     1  1|     41  1.7|
      Mixed Cell Focus                     | X     X  X  X     X  X  X        X  X  X                 X        X  X   |     25     |
      Necrosis                             |                         2                    3                           |      3  2.3|
      Pigmentation                         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1              1  1  2           1  1           1     1  2  1  1  1      |     25  1.2|
      Hepatocyte, Degeneration, Cystic     |                      2                                                   |      1  2.0|
      Hepatocyte, Hyperplasia              |                                                          4               |      1  4.0|
      Hepatocyte, Vacuolization Cytoplasmic| 1           1  1  1  2  2  3  1  1  1  2  1  3  1  1  1  2           1  1|     32  1.4|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +                          +                       +  +        +      |   9        |
      Fat, Inflammation, Chronic           |    4                          3                       3  2               |      8  2.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3|            |
                                           | 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Mineralization                  |                               1                          1               |      5  1.2|
      Fat, Necrosis                        |                               4                       4  4               |      7  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +              +  +  +     +  +  +                                +   |  11        |
      Foreign Body                         |    X              X  X        X     X                                X   |      9     |
      Gingival, Hyperplasia, Squamous      |                         2                                                |      1  2.0|
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                   2  2  3        2  2                                2   |      8  2.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |       2                                1        1  2  2  1           2  4|     14  1.7|
      Acinus, Hyperplasia                  |       3                                                                  |      1  3.0|
      Duct, Cyst                           |       2              2                             2     2               |      8  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1  1                    2     1           1  1  1  1  1           2|     19  1.3|
      Basophilic Focus                     |       X        X                                   X                     |      7     |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Ectasia                      | 1  1  1  1  1  1  1  1           1  1  1  1     1     1     1  1  2  1  1|     36  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2     2  2  2     1  2  2  2  1  2  1  2  2  2  2  2  1  2     2  2|     45  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3|            |
                                           | 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2  1.5|
      Angiectasis                          |          3                                                               |      1  3.0|
      Hematopoietic Cell Proliferation     |                                  1                                       |      1  1.0|
      Hyperplasia                          | 1     1  2                    2                       1  2               |     17  1.7|
      Hypertrophy                          |       1                 2                                                |      4  1.8|
      Necrosis                             |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |       1  2     1  2     2                             2  1  1     2  2   |     18  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2                                                  2         |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  M  M  +  M  +  +  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                         2                             2                  |      2  2.0|
      Pars Distalis, Cyst                  | 2  2     1  2  3                 3     1  2     2  2  1  2  2     2     2|     27  1.9|
      Pars Distalis, Hyperplasia           |    2     2  3     2     2        2              2        2               |     19  2.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1     1     1  2  2           1  1  1  1  1        1  1  2     2     1   |     33  1.2|
      Follicle, Cyst                       |                                     2                                    |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2                 2                 3     2        3         |     11  2.2|
      Inflammation, Chronic Active         |             1  1                 2              2        1     2         |      9  1.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3|            |
                                           | 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Duct, Cyst                           | 2           2                 2  2              3     3        3         |     16  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       4        2                             3     4        2            |      5  3.0|
      Granulosa Cell, Hyperplasia          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |             2                                                            |      2  2.0|
      Cervix, Epithelium, Hyperplasia      |                         3                                                |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |             2  1                 1                 2                     |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3                       4     3        4  4           4  3     4  4   |     16  3.8|
      Myelofibrosis                        |    2                                                              2      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +           +  +           +                    +  +  +     +  +  +   |  25        |
      Mediastinal, Ectasia                 | 2  2           2  2           2                    2           2     2   |     17  2.0|
      Mediastinal, Hyperplasia, Lymphoid   | 2  2           2  2           2                    2  2        3     3   |     20  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +|   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                 2                        |      1  2.0|
      Hematopoietic Cell Proliferation     |             2                    2                                   3   |      5  2.4|
      Hyperplasia, Lymphoid                |    4                                                                     |      1  4.0|
      Infarct                              |                                                                   4      |      1  4.0|
      Pigmentation                         |                                                 3                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3|            |
                                           | 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Ectopic Parathyroid Gland            | 2                                                                        |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         4                                4               |      3  4.0|
      Cyst, Multiple                       |                                                                          |      1  4.0|
      Hyperplasia, Cystic                  | 2  2  2  2  2  2  3  2  3     3  3  1  2  4  2  2  4  2  4  2  3  3  4  2|     47  2.4|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                      4   |      1  4.0|
      Inflammation, Chronic Active         |                                                                      4   |      1  4.0|
      Epidermis, Hyperplasia               |                                                                      3   |      1  3.0|
      Epidermis, Ulcer                     |                                                                      4   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                               2                                      2   |      3  2.3|
      Hydrocephalus                        |                               2                                      2   |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 2  2  1  1  1  1  1  1  1     2     1  2        1  1  1     1  1     1  2|     36  1.1|
      Mineralization                       | 1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1   |     45  1.0|
      Pigmentation                         | 2  2  1  1  1  1  1  1  1     1  1  1  1  1     1  1  1  1  1  1     1  1|     47  1.0|
      Alveolar Epithelium, Hyperplasia     |                   2     2           1  2           1  1        2         |     12  1.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3|            |
                                           | 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Focal, Squamous                 |                                                                          |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2  2  1  1  1  1  1  1  1     1  1  1  1  1     1  1  1  1  1  1     1  1|     47  1.1|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Thrombosis                           |                      2                                                   |      3  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                            3                          2                 2|      5  2.4|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                   3      |      1  3.0|
      Cyst                                 |                                                                          |      1  3.0|
      Hydronephrosis                       |                      2                                                   |      1  2.0|
      Mineralization                       | 1  1     1  1  1  1  1     1  1  1  1        1  1  1  1  1  1  1        1|     38  1.0|
      Nephropathy                          | 1  1  1  1  1  1  2  1  1  1  2  2  2  1  1     2  2  2  1  1  1  2  1   |     43  1.3|
      Pigmentation                         |                                                                          |      1  3.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|             
                                           | 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .312%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         4|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X  X     X  X  X  X  X  X     X  X  X  X     X  X  X  X  X|             
      Clear Cell Focus                     |    X                                                     X               |             
      Hematopoietic Cell Proliferation     |                                              1                           |             
      Hepatodiaphragmatic Nodule           |                X                    X     X                 X            |             
      Inflammation, Chronic Active         | 2  1  3     2  2  2     2  2  2  2  2  1     1  2  2  2  2  2  1  2  2  2|             
      Mixed Cell Focus                     |    X        X  X  X     X  X  X  X  X     X           X              X  X|             
      Necrosis                             |                      3                    3                              |             
      Pigmentation                         |                                                                          |             
      Thrombosis                           |                      2                                                   |             
      Bile Duct, Hyperplasia               | 1     1     1     1  3     1  1  1  1           1  1  1              1   |             
      Hepatocyte, Hyperplasia              |             3              2                                             |             
      Hepatocyte, Vacuolization Cytoplasmic| 1        3  1  2  1     1  1  1     1     2        1     3  1     1  1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                    +                 +                                 |             
      Inflammation, Chronic                |                      4                                                   |             
      Fat, Inflammation, Chronic           |                                        3                                 |             
      Fat, Mineralization                  |                                        2                                 |             
      Fat, Necrosis                        | 4                                      4                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|             
                                           | 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .312%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +  +  +  +  +  +  +     +  +  +        +     +     +              +   |             
      Foreign Body                         |    X  X  X  X  X  X  X     X  X  X        X     X     X              X   |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |       2                       2           4                              |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1                                      1     1              1     1     2|             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Cyst                           |    2                                   2                                 |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1                       2        1     2                  |             
      Basophilic Focus                     |                X  X     X           X                 X                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperkeratosis           |                                        2                 2               |             
      Epithelium, Hyperplasia              |                                        2                 2               |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Ectasia                      | 1     1     1  1  1     1  1  1  1  1  1     1  1           1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                           M                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  1  2  2  2  3  1  2  1  2  2     3     2  2  2  1  2  2  2  2  2|             
      Mineralization                       |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                       2                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|             
                                           | 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .312%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 1                 1                                                      |             
      Hyperplasia                          | 1  1                    2  2                                         2  1|             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                                           3                              |             
      Vacuolization Cytoplasmic            | 2        3  1  1  1           1     1  1                 1     1  1     1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                      2                                            1      |             
      Pars Distalis, Cyst                  |    2  4  3     3  2     1  2                 3  2  3  2     1  3  1  2  1|             
      Pars Distalis, Hyperplasia           |          3              2  2     1                    3        4  1  2   |             
      Pars Distalis, Mineralization        |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ultimobranchial Cyst                 |                                                                1         |             
      C-Cell, Hyperplasia                  | 2     2  1              1     2        1        2     2     1     1      |             
      Follicular Cell, Hyperplasia         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2  4     4     2     2     2              4        2        1   |             
      Inflammation, Chronic Active         |       1     3     1     1        1  2              3  1           1  1   |             
      Duct, Cyst                           |                                                             2        3  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3                                    |             
      Cyst                                 |             2        4           2                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|             
                                           | 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .312%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Mineralization                       |                                                 1                        |             
      Interstitial Cell, Hyperplasia       |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |          4  2                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          4                 3           4  4  3                 3     3   |             
      Myelofibrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +        +     +     +     +           +     +  +  +      |             
      Deep Cervical, Ectasia               |                                                                2         |             
      Deep Cervical, Hyperplasia, Lymphoid |                                                                2         |             
      Deep Cervical, Inflammation, Chronic |                                                                          |             
      Mediastinal, Ectasia                 | 2  2  2        2        1     2     2                 2     2     2      |             
      Mediastinal, Hyperplasia, Lymphoid   | 2  3  3  3     2        3     2     3                 3     2     2      |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
      Mediastinal, Pigmentation            |    2  2                                                                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          3                             3     3                       2   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|             
                                           | 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .312%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Hyperplasia, Cystic                  | 2  2  2  2  4  2  2     2  2  2  3  2  2     3  2  3  2  3  3     2  2  2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                2                                         3               |             
      Hydrocephalus                        | 2           2  2              2                    2     3               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic Active         | 1  1  1  1  2  1  1     2  1  1     1  1     1  2  1  1  1  1  1  1  1  1|             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         | 1  1  1  1  1  1  1     1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     |                   1     2  3     3  2           1  1  1     1            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1  1  1  1  1  1     1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 1           2                                                            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                +                                      +                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|             
                                           | 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .312%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Lens, Cataract                       |                4                                      4                  |             
      Retina, Degeneration                 |                4                                      4                  |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +        +                                                               |             
      Cyst                                 | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Mineralization                       |       1  1     1                 1  1  1     1     1  1  1     1     1   |             
      Nephropathy                          | 1  1  2     1  2  2     1  1  2  2     1     1  1  1  1     2  1  1  2  2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3|            |
                                           | 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    .312%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             X                                                            |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X        X  X  X  X  X  X  X  X     X  X     X  X  X  X  X  X|     42     |
      Clear Cell Focus                     |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |                                                 2                 2      |      3  1.7|
      Hepatodiaphragmatic Nodule           |             X  X        X  X  X     X              X  X                  |     12     |
      Inflammation, Chronic Active         | 3  2  1     3        2  2  2  1  2  2  2  1  1     1     1  2  2  1  2  2|     42  1.8|
      Mixed Cell Focus                     |       X                 X     X           X     X  X     X  X  X     X  X|     24     |
      Necrosis                             |                                              2                 1         |      4  2.3|
      Pigmentation                         |             1                                                            |      1  1.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  1        2  2     1  1        1  1     1  1     1  2  1     1     1   |     28  1.2|
      Hepatocyte, Hyperplasia              |                                                                          |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|          1     4     1  1        1        1  3        3     1     1      |     25  1.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +     +                                                           +      |   6        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3|            |
                                           | 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    .312%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Fat, Inflammation, Chronic           | 3     2                                                           3      |      4  2.8|
      Fat, Mineralization                  | 2                                                                        |      2  2.0|
      Fat, Necrosis                        | 4     4                                                           4      |      5  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +     +  +     +  +  +  +                 +     +        +               |  24        |
      Foreign Body                         | X     X  X     X  X  X  X                 X     X        X               |     24     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           | 1     2  2     2     2                                                   |      8  2.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |    1                       1     1           1     2  2  1     2         |     14  1.3|
      Acinus, Hyperplasia                  |                                                                   1      |      1  1.0|
      Duct, Cyst                           |    2                                                     2               |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |    1        1        2                                   1               |      8  1.4|
      Basophilic Focus                     |          X                                                               |      6     |
      Inflammation, Chronic Active         | 2                                                     1                  |      2  1.5|
      Mineralization                       |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperkeratosis           |                                                                          |      2  2.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Ectasia                      |    1  1  1     1     1  1  1  1  1  1  1  1     1        1     1  1  1  1|     36  1.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3|            |
                                           | 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    .312%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2  1  2  2        2  2  2  2  2  1  2  2  1  2  2  2  2  1  2  2  2  2|     45  1.9|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                            1        1           1                        |      5  1.0|
      Hyperplasia                          |          2                                                           2  2|      9  1.7|
      Hypertrophy                          |             1                                         1                  |      2  1.0|
      Necrosis                             |                                              2                           |      2  2.5|
      Vacuolization Cytoplasmic            | 1  1     1  1        1     2     1        2  2        1  1     2        1|     25  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                    1                                   2      |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                    3                     |      3  2.0|
      Pars Distalis, Cyst                  | 2  2  1  1  1                 2        2        2              2  2  2   |     27  2.0|
      Pars Distalis, Hyperplasia           |    2  2  2  2           2           3  2     2  4              2  3  2  2|     21  2.3|
      Pars Distalis, Mineralization        |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                | 4                                                                        |      1  4.0|
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  | 1  2  1        1     1  2  1  2  1  2  1           1                    1|     23  1.4|
      Follicular Cell, Hyperplasia         |                      1                                                   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3|            |
                                           | 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    .312%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2           3              2  1  3                       2           2|     17  2.4|
      Inflammation, Chronic Active         |          4  1        1  1  1  1  1  2              2     1              2|     21  1.5|
      Duct, Cyst                           |                2              3  2        3                              |      7  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |                            2                          4                  |      5  2.8|
      Mineralization                       |                                                                          |      1  1.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                         4|      1  4.0|
      Hydrometra                           |             3                 3                                      2   |      5  2.8|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                 1              2         |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          3                          4        4  4     4           4      |     13  3.6|
      Myelofibrosis                        |    3           4                                                         |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +           +  +  +  +        +  +     +        +        +|  26        |
      Deep Cervical, Ectasia               |                                                                          |      1  2.0|
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
      Deep Cervical, Inflammation, Chronic | 4                                                                        |      1  4.0|
      Mediastinal, Ectasia                 |    2     2     2           2  2  2  3        2  2              2        2|     21  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |    2     3                 3  2  2  2        2  2              2        2|     21  2.4|
      Mediastinal, Inflammation, Chronic   | 4                                                                        |      1  4.0|
      Mediastinal, Pigmentation            |                            2                    2                        |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3|            |
                                           | 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    .312%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |          2                          3           3                 3      |      8  2.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|  47        |
      Ectopic Parathyroid Gland            | 2                       2                             1                  |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      4           3     4                                 |      3  3.7|
      Hyperplasia, Cystic                  |    1  1  2  2  2     3  2  2  2  3  4  2  3  2  2  2  2  2  3  2  3  2  2|     45  2.3|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                3                                                         |      3  2.7|
      Hydrocephalus                        |                3     1                    2                 2            |     10  2.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3|            |
                                           | 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    .312%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Inflammation, Chronic Active         |    2  2  1  1        1  1     1  1  1  1  1        2     1  1  2  1  2  1|     40  1.2|
      Mineralization                       | 1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1     1  1     1  1  1  1|     47  1.0|
      Pigmentation                         | 1  1  1  1     1     2  1     1  1  1  1  1     1  1  1  1  1  1  1  1  1|     44  1.0|
      Alveolar Epithelium, Hyperplasia     |       1                 1     2                          2     3        2|     15  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1  1  1     1     2  1     1  1  1  1  1     1  1  1  1  1  1  1  1  1|     44  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                               2                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   3        |
      Lens, Cataract                       |                                                                   2      |      3  3.3|
      Retina, Degeneration                 |                                                                   3      |      3  3.7|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Cyst                                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |             2                                                            |      1  2.0|
      Mineralization                       | 1  1  1  1  1  1        1           1     1  1     1  1  1  1  1     1   |     28  1.0|
      Nephropathy                          |    2  2  2  1  1     1  1  2  1  1  1  1  2  1  2  2     1  1  2     1  1|     41  1.4|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|             
                                           | 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .625%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                X   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X     X  X     X  X  X  X  X  X  X  X     X  X  X  X  X  X  X|             
      Hepatodiaphragmatic Nodule           | X     X        X              X                             X            |             
      Inflammation, Chronic Active         | 2  2     3  1  2  1  3  1  1  2  3  1  2     3  2     2  2  2  2  2  2  2|             
      Mixed Cell Focus                     |    X  X  X     X           X  X     X        X  X     X  X     X  X  X  X|             
      Necrosis                             |                                           3                              |             
      Bile Duct, Hyperplasia               | 1  1     1  1  1     1              1        1     1  1     1  1  1  1   |             
      Hepatocyte, Vacuolization Cytoplasmic|                            1                 1     1        2  1     1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                                   +           +                        |             
      Fat, Inflammation, Chronic           | 2                                   2           2                        |             
      Fat, Mineralization                  | 2                                   2                                    |             
      Fat, Necrosis                        | 4                                   4           4                        |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +  +                             +  +  +                          +|             
      Foreign Body                         |       X  X                             X  X  X                          X|             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                         1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|             
                                           | 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .625%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation, Chronic Active         |       1     2                                                            |             
      Acinus, Atrophy                      |                2                    1                                    |             
      Duct, Cyst                           | 2                                      2                                 |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2           1                    1     2     2      |             
      Basophilic Focus                     |       X                       X                                X        X|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             4            |             
      Epithelium, Hyperkeratosis           |                                                                          |             
      Epithelium, Hyperplasia              |                                                             2            |             
      Epithelium, Ulcer                    |                                                             4            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Ulcer                    |                                                                          |             
      Glands, Ectasia                      | 1  1  1  1  1  1  1  1     1     1  1  1     1  1  1  1  1     1  1  1   |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  1  2     1        2  2  2     2  2  2     2  2  1  2  2  2  2|             
      Mineralization                       |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                1                       1                                 |             
      Hyperplasia                          | 2  1  2        2                                                         |             
      Hypertrophy                          |                            2                                      2      |             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|             
                                           | 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .625%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Vacuolization Cytoplasmic            |       1        2           1                 1                 1  2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        3                                                            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |       2                 1  2           3     2           3     2  2  3   |             
      Pars Distalis, Hyperplasia           | 2  1  2  2     2     2     2  1  3                    2  2     2     2  1|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                   1                                                      |             
      C-Cell, Hyperplasia                  | 1  2  1  1  1                 1  2  2           1     1  1              2|             
      Follicle, Cyst                       |                                        2                                 |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                3  2     2           2               |             
      Inflammation, Chronic Active         |    2        1     1                    2     2     4     1     1  2  1   |             
      Duct, Cyst                           |             2           2     3              4                       2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                2                                                         |             
      Mineralization                       |                1                                                         |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    3                                            2                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|             
                                           | 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .625%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3                    4  4        2                     |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +           +        +        +  +  +        +     +  +|             
      Deep Cervical, Ectasia               |                                                                          |             
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |             
      Deep Cervical, Pigmentation          |                                                                          |             
      Mediastinal, Ectasia                 | 2  2  2     2     2           2        2        2     2        2     2  2|             
      Mediastinal, Hyperplasia, Lymphoid   | 2  2  2     2     3           2        3        2     2        2     2  2|             
      Mediastinal, Pigmentation            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                2                       2                                 |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       4                             4                                    |             
      Hyperplasia, Cystic                  | 2  2  2  2  2  2           2  2  2  2  2           4     2  2  2  1  2  2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                             3            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|             
                                           | 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .625%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
      Hemorrhage                           |                         2                          1                     |             
      Hydrocephalus                        |                                                    2        2            |             
      Inflammation, Chronic Active         |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1     1  1  1  2     1  1  1  1  2  1     1  1     1  1     1  1  1  1|             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1     1  1  1  1  1|             
      Pigmentation                         | 1  1  1  1  1  1  1  1     1  1  1  1  1     1  1     1  1  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     |       2        1     2     1     2  1        2        2  1     2         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1  1  1  1  1  1  1     1  1  1  1  1     1  1     1  1  1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2        2                                                   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Retina, Hemorrhage                   |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  1  1        1  1  1  1  1  1  1     1  1  1     1  1  1  1  1        1|             
      Nephropathy                          | 1  1     1     2  1  1  1  2  1  2  1        1  1  2  1  1  1  1         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|             
                                           | 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .625%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                      3   |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                      2   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3|            |
                                           | 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    .625%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |    X                          X                                      X   |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                X         |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |    X  X        X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     43     |
      Hepatodiaphragmatic Nodule           |          X     X                                                     X  X|      9     |
      Inflammation, Chronic Active         |    2  2        2        2  2  1  1  1  2  1  1  2  1  2  1  2  2  1  1  2|     42  1.8|
      Mixed Cell Focus                     |    X           X     X  X  X     X  X  X  X  X  X                 X      |     27     |
      Necrosis                             |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |       1        1        1  1  1                    1                    1|     21  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|          4  3  1     1     1              1     1                    1   |     14  1.4|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                   +     +  +           +                          +  +   |   9        |
      Fat, Inflammation, Chronic           |                   3        2           3                          2  2   |      8  2.3|
      Fat, Mineralization                  |                         1  2                                      1      |      5  1.6|
      Fat, Necrosis                        |                   4     4  4           4                          4  4   |      9  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                +     +        +  +  +  +  +  +                 +  +  +  +|  18        |
      Foreign Body                         |                X     X        X  X  X  X  X  X                    X  X  X|     17     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3|            |
                                           | 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    .625%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Active                           |                               2                                2         |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                              X                           |      1     |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Acinus, Atrophy                      |                            1           1     1                           |      5  1.2|
      Duct, Cyst                           |       2                                      2                           |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      5  1.6|
      Basophilic Focus                     |                      X                       X                           |      6     |
      Vacuolization Cytoplasmic            |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |          3                                                               |      2  3.5|
      Epithelium, Hyperkeratosis           |          2                                                               |      1  2.0|
      Epithelium, Hyperplasia              |          2                                                               |      2  2.0|
      Epithelium, Ulcer                    |          4                                                               |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |          3  2                                                            |      2  2.5|
      Epithelium, Ulcer                    |          4  2                                                            |      2  3.0|
      Glands, Ectasia                      |    1  1  1     1  1  1  1  1  1  1  1        1  1  1  1     1     1  1  1|     39  1.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       |    2  2  2  2  2     2  2  2  1  2  2  2  2  2  2  2  2  1  2  2  2  2  2|     43  1.9|
      Mineralization                       |                                              1                           |      1  1.0|
      Valve, Thrombosis                    |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3|            |
                                           | 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    .625%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hyperplasia                          |                            1  1              2  1  1     2           2  1|     12  1.5|
      Hypertrophy                          |                                                 1                        |      3  1.7|
      Necrosis                             |                   2                                                      |      1  2.0|
      Vacuolization Cytoplasmic            |    1  1  4  4     3  1                       2  1  1  2     1     1  1   |     19  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                           2                              |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                          4               |      1  4.0|
      Pars Distalis, Cyst                  |             2     2        2  1  2        1  1  3  1        2            |     19  1.9|
      Pars Distalis, Hyperplasia           |       2                    4     2        2  2                 1  1  1  3|     23  1.9|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ultimobranchial Cyst                 |                                           2                              |      2  1.5|
      C-Cell, Hyperplasia                  |    1  1        1  1  1  1  3  1  1  1           1  2        1  1  2     2|     28  1.3|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                1     2  2        2                 4              2      |     11  2.2|
      Inflammation, Chronic Active         |                            1  1                    3           1        1|     15  1.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3|            |
                                           | 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    .625%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Duct, Cyst                           |                      4              2  2                          2      |      9  2.6|
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                            2              4        4                     |      4  3.0|
      Mineralization                       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydrometra                           |       2                                2           3                     |      5  2.4|
      Inflammation, Chronic Active         |             1                                                            |      1  1.0|
      Endometrium, Hyperplasia, Cystic     |             2                       2                                    |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          4  3     4           3     4                             3  3   |     11  3.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +     +     +  +              +     +     +     +  +        +        +|  24        |
      Deep Cervical, Ectasia               |                2                                      2        3         |      3  2.3|
      Deep Cervical, Hyperplasia, Lymphoid |                3                                      2        2         |      3  2.3|
      Deep Cervical, Pigmentation          |                                                       1                  |      1  1.0|
      Mediastinal, Ectasia                 |    2           2                 2     2     2     2  2                 2|     20  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |    2           3                 3     3     2     3  2                 2|     20  2.3|
      Mediastinal, Pigmentation            |                                                       2                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                   2      |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectopic Parathyroid Gland            |                                  2                                       |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3|            |
                                           | 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    .625%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                             4            |      3  4.0|
      Hyperplasia, Cystic                  |    2  2     2  3     2  2  2     2     2  2  2  3  2  2  2  2     2  2  2|     37  2.1|
                                           |__________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |                      2                                                   |      2  2.5|
      Hemorrhage                           |                                                                          |      2  1.5|
      Hydrocephalus                        |                2     2                                                  2|      5  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                   +                                                      |   1        |
      Hemorrhage                           |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |    1  1        1     1  1  1     1     1  1  1  1  1  1  1  1     1  1  1|     37  1.1|
      Mineralization                       |    1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1|     45  1.0|
      Pigmentation                         |    1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   |     44  1.0|
      Alveolar Epithelium, Hyperplasia     |       1                                2                          1      |     13  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   |     44  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3|            |
                                           | 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    .625%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Thrombosis                           |             4                                                            |      1  4.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             4     2                                            3        2|      6  2.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Retina, Hemorrhage                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |    1  1     1  1  1  1        1        1              1  1  1  1  1     1|     33  1.0|
      Nephropathy                          |    2  2  3  1  1  1  1     1  1     2  1  2  2  1  2        2  1  1  1  1|     38  1.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|             
                                           | 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                                |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X  X  X  X  X  X  X  X  X        X  X  X  X  X  X  X  X  X  X  X|             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                         1                                                |             
      Hepatodiaphragmatic Nodule           |                   X                       X     X                        |             
      Inflammation, Chronic Active         | 2  2     2  1  2  2  2  1     2  2        2  2  2  1  2  2     2  3  2  1|             
      Mixed Cell Focus                     | X  X           X           X     X        X  X        X                  |             
      Necrosis                             |                      2  2                                                |             
      Bile Duct, Hyperplasia               |       2     1           1              2                          1      |             
      Hepatocyte, Vacuolization Cytoplasmic|       2        1           1           4     1  2     1  1           1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                   +                       +                    +         |             
      Hemorrhage                           |                                                                          |             
      Fat, Inflammation, Chronic           |                                           3                    3         |             
      Fat, Mineralization                  |                   2                       1                              |             
      Fat, Necrosis                        |                   4                       4                    4         |             
      Fat, Pigmentation                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                      +                 +                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|             
                                           | 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Foreign Body                         |                      X                 X                                 |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Gingival, Necrosis                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |    1  2           1     2           3                             1      |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1     2  1  1              2           2              1      |             
      Basophilic Focus                     |                                                    X              X      |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperkeratosis           |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Erosion                  |                                                                          |             
      Glands, Ectasia                      | 1  1  1  1  1  1     2     2     1  2  1  2  1  2  1     1     1        1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2     2  2  2           2  2  2  2  2  2     1     2  1  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                        2                                 |             
      Hematopoietic Cell Proliferation     |                                                                1         |             
      Hyperplasia                          |             2  1                 2                 2                     |             
      Hypertrophy                          |                                  2                                       |             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|             
                                           | 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Vacuolization Cytoplasmic            |          1  2     3              1     3        1                        |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        1                                 |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | 2  3  2  2  2  2                 2     2  1        1                 2   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 2     4  2  2  2                 2           2           1     1  2  4   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                            2     1  1  2  1  1  2  1  1  1     1     2   |             
      Follicular Cell, Hyperplasia         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                            2           2        2      |             
      Inflammation, Chronic Active         |             2              1        1              1              1      |             
      Mineralization                       |                                                                          |             
      Duct, Cyst                           | 3           4                                2           2        2      |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |    +                                                                     |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                    2                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|             
                                           | 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       4              4  4           4  4           3              3  3   |             
      Myelofibrosis                        |                                     3  2                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +  +  +  +  +        +  +  +  +        +           +  +   |             
      Deep Cervical, Hyperplasia, Lymphoid |                         2                                                |             
      Mediastinal, Ectasia                 |             2  2  2  2     2           2  2  3        3           2  2   |             
      Mediastinal, Hyperplasia, Lymphoid   |    2        3  2  2  3     2           3  2  3        2           3  2   |             
      Mediastinal, Pigmentation            |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   2  2  3                                            3   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                               3                             3            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                                           1     2     2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  2  3  2           3  2  2  1  2  2  3  2  3  2  2  2  2     1  2  2  2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic Active         |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|             
                                           | 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       3                  |             
      Hemorrhage                           |                                        1                 1               |             
      Hydrocephalus                        |                                                       3                  |             
      Necrosis                             |                                                                          |             
      Meninges, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      2   |             
      Inflammation, Chronic Active         | 2  1     1  1  2  1  1     2              1  1  1  1  1  1           2  1|             
      Mineralization                       | 1     1  1  1     1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         | 1  1     1  1  1  1  1     1  1  1     1  1  1  1  1     1     1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     |             1           2  3                             1               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1     1  1  1  1  1     1  1  1     1  1  1  1  1     1     1  1  1  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                   X      |             
      Inflammation, Chronic Active         |                                                                   2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2                                                            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|             
                                           | 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
      Mineralization                       | 1  1  1  1     1        1        1     1  1           1           1  1   |             
      Nephropathy                          | 2  1  2  1  1  1     1     2  1  2  2  1  2     2  1  2  2     1  2     2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3|            |
                                           | 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                        X                                 |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X        X  X|     44     |
      Eosinophilic Focus                   |                         X                                                |      1     |
      Fibrosis                             |                                                    2                     |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |          X                    X        X                    X            |      7     |
      Inflammation, Chronic Active         | 2  2  2     2  2  2  2  2  2  2  3  2  1  2  1  2  1  2  1  3  1     2  2|     43  1.9|
      Mixed Cell Focus                     |    X  X        X     X  X     X  X           X  X  X  X  X               |     20     |
      Necrosis                             | 2        2           1                                            2      |      6  1.8|
      Bile Duct, Hyperplasia               |    2              1  1  1  1  1  1           1  1     1  1     1        1|     18  1.2|
      Hepatocyte, Vacuolization Cytoplasmic|       1        1           1     1              1  1  1  1        2      |     18  1.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                             +                             +  +     +   |   8        |
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Fat, Inflammation, Chronic           | 3                             3                             2  3     2   |      7  2.7|
      Fat, Mineralization                  |                               2                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3|            |
                                           | 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis                        |                               4                             4  4     4   |      7  4.0|
      Fat, Pigmentation                    |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                  +  +                                   +|   5        |
      Foreign Body                         |                                  X                                      X|      4     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                  2                                       |      1  2.0|
      Gingival, Necrosis                   |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       1                                                                  |      1  1.0|
      Acinus, Atrophy                      |                   2     1        2  1                 2                  |     11  1.6|
      Acinus, Hyperplasia                  |                                                       2                  |      1  2.0|
      Duct, Cyst                           |                                                    2                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                        1           1           2     1   |     11  1.4|
      Basophilic Focus                     |       X                                                                  |      3     |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Epithelium, Hyperkeratosis           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Erosion                  |                                                                1         |      1  1.0|
      Glands, Ectasia                      | 1  1  1  1  1  1  1     1  1  1  1     1     1     1  1  1  1  1     1  1|     38  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  2  2  2  1  1  2  2  2  2  1  2  1  2  2  2  1  2  2  2  1  3  2  2|     44  1.8|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3|            |
                                           | 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |    1  2           1                    1  2        1                     |     10  1.5|
      Hypertrophy                          |                                           2                              |      2  2.0|
      Necrosis                             |          4                                                               |      1  4.0|
      Vacuolization Cytoplasmic            |    1  2  2     1     1           1  2     1     1  1           4  3  1  1|     20  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1                                               3                  |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |    1  2  1           3        1           1           2  2     2  1  1   |     22  1.7|
      Pars Distalis, Hemorrhage            |                            2                                             |      1  2.0|
      Pars Distalis, Hyperplasia           | 2           2           2     2              2  1              2  1  2  2|     21  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                 1                        |      1  1.0|
      C-Cell, Hyperplasia                  |                1     1     1  2        1        1     1  2              2|     21  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1  2                    2                                                |      7  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3|            |
                                           | 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic Active         |       1        1     1                       1  1        2  1            |     12  1.2|
      Mineralization                       |       1                                                                  |      1  1.0|
      Duct, Cyst                           | 2                       2  2           3                 2        2      |     11  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                4                          4                              |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                                          3        4      |      3  3.0|
      Endometrium, Hyperplasia, Cystic     |                         2                             2              2   |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          4                          4              3           4  3      |     13  3.6|
      Myelofibrosis                        |          2                                                     2         |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +           +  +     +                    +  +           +  +  +  +  +  +|  27        |
      Deep Cervical, Hyperplasia, Lymphoid |                                                          2  3            |      3  2.3|
      Mediastinal, Ectasia                 | 2           2  2     2                    2  2              2     2  2  2|     21  2.1|
      Mediastinal, Hyperplasia, Lymphoid   | 2           2  2     2                    2  2              3     2  2  2|     22  2.3|
      Mediastinal, Pigmentation            |             2                                                            |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M|   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                     2                             3      |      6  2.5|
      Hyperplasia, Lymphoid                | 4                                                                        |      1  4.0|
      Pigmentation                         |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3|            |
                                           | 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectopic Parathyroid Gland            |    1                                   1        2                        |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 2        2  2  3  2  2  2  2  2  2     2  1  3  3  2  2  3     2  2  2  1|     42  2.1|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                    X                     |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                3  3                    3           3                     |      5  3.0|
      Hemorrhage                           |                                                                2         |      3  1.3|
      Hydrocephalus                        |                2  3  2           2     2           3        2            |      8  2.4|
      Necrosis                             |                                                                2         |      1  2.0|
      Meninges, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 1  1  1     1  1  1  1     1  2        1  1  1  1  1     1  1        1   |     33  1.2|
      Mineralization                       | 1  1  1  1     1     1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1|     44  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3|            |
                                           | 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1|     44  1.0|
      Alveolar Epithelium, Hyperplasia     |       1     2           1        2        2                              |      9  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     45  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation, Chronic Active         |                      2                                                   |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |          2                                                               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                              +                          +|   2        |
      Lens, Cataract                       |                                              4                          4|      2  4.0|
      Retina, Degeneration                 |                                              4                          3|      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |          4                                                               |      1  4.0|
      Infiltration Cellular, Lipocyte      |                                                             2            |      1  2.0|
      Mineralization                       | 1  1  1     1  1  1  1  1        1     1  1  1  1  1     1        1  1  1|     30  1.0|
      Nephropathy                          | 2  1  2     1  2     2  1  1  1  2     1  1  1  2     2  1  1  1     1  1|     40  1.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|             
                                           | 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X        X                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X        X  X           X  X  X        X        X     X  X     X|             
      Clear Cell Focus                     |                                                                X         |             
      Eosinophilic Focus                   |                   X                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                X        X|             
      Inflammation, Chronic Active         | 1  1  1  1  1     2        2     2  1  1        1  1  1  1     2  1     3|             
      Mixed Cell Focus                     | X  X  X  X        X        X        X           X              X         |             
      Necrosis                             |       2                                            2                     |             
      Bile Duct, Cyst                      |                                        2                                 |             
      Bile Duct, Hyperplasia               | 2  1  2  2     2  1  3  1  2  2  2  1  1  2  2  1  1  1  1     2  2  3  2|             
      Hepatocyte, Degeneration, Cystic     |                1                          1                              |             
      Hepatocyte, Hyperplasia              |       2                                                                  |             
      Hepatocyte, Vacuolization Cytoplasmic|             3           2  1        1  1     3  1  4  1                  |             
      Portal, Fibrosis                     |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +        +     +  +                          +           +     +  +|             
      Fat, Inflammation, Chronic           |       3              3                             3           3     3  3|             
      Fat, Mineralization                  |       1                                            2           1     1  2|             
      Fat, Necrosis                        |       4              4                             4           4     4  4|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|             
                                           | 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Oral Mucosa                             | +  +                 +     +                             +        +  +   |             
      Foreign Body                         | X  X                 X     X                             X        X  X   |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           | 2  2                 2     2                                      2  1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1  1        1  1     1              2              1                    1|             
      Duct, Cyst                           |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                       3  1              2                          1   |             
      Basophilic Focus                     |    X  1           X  X     X        1           X              X         |             
      Hyperplasia                          |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic Active         |                         2                          3                     |             
      Epithelium, Hyperkeratosis           |             2                                      2                     |             
      Epithelium, Hyperplasia              |             2           2                          3                     |             
      Epithelium, Ulcer                    |                         3                          4                     |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          2               |             
      Mineralization                       |                                                                          |             
      Epithelium, Ulcer                    |                                                          2               |             
      Glands, Ectasia                      | 1  1     1  1  1  1     1  1     1  1  1  1     1  1  1  1     1  1  1   |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
      Media, Mineralization                |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  1        2  2     2  2  2  2  2  2  2  2  2  2  1        2  1  1|             
      Inflammation, Chronic Active         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|             
                                           | 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Atypia Cellular                      |                                                                          |             
      Hematopoietic Cell Proliferation     | 1                                                                        |             
      Hyperplasia                          | 1     2     1     1        1     1  1              2                    1|             
      Hypertrophy                          |                                           1        1                     |             
      Vacuolization Cytoplasmic            | 2     1  1  3  2        4              2     2  3  2  2  2  1     1  1  2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                 2      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                               2                                      2   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |             1        2  1           2                 1        1  2  2   |             
      Pars Distalis, Inflammation,         |                                                                          |             
          Suppurative                      |                                                                          |             
      Pars Distalis, Mineralization        |                                                                          |             
      Pars Intermedia, Cyst                |                                                                         2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                  2                                       |             
      C-Cell, Hyperplasia                  | 1     2              1     1           1           1  1        1     1  1|             
      Follicle, Cyst                       |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|             
                                           | 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                        2              2                  |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                            3        2           2      |             
      Inflammation, Chronic Active         | 2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Mineralization                       |                                                                          |             
      Duct, Ectasia                        |                                              3           4               |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration                         |    3                                                                     |             
      Inflammation, Chronic Active         | 2        2     1                          1     2  2     2           1  2|             
      Mineralization                       |    2                                                                     |             
      Epithelium, Hyperplasia              |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      4                                                   |             
      Mineralization                       | 1     1     1  1  1  1  1  2  1  1  1  1  1     1  1  1  1     1  1  2  1|             
      Germinal Epithelium, Atrophy         |                                                                          |             
      Interstitial Cell, Hyperplasia       |             2        1                             1                    1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  4  3        4  4     4     4  4     3  4  4        3  3  3  3     4   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +           +        +     +  +  +  +  +  +  +     +        +     +  +|             
      Ectasia                              | 3  2                                                                     |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Deep Cervical, Ectasia               |    2                                                                     |             
      Deep Cervical, Hyperplasia, Lymphoid |    2                                   2     2                           |             
      Mediastinal, Ectasia                 |                                     2           2                        |             
      Mediastinal, Hyperplasia, Lymphoid   |                                     2           2     3        3         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|             
                                           | 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pancreatic, Ectasia                  |                                                                         2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
      Ectasia                              |          3                                                               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      1                                                   |             
      Hematopoietic Cell Proliferation     |                   2                                                      |             
      Hyperplasia, Lymphoid                |                   4                                                     4|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         4|             
      Hyperplasia, Cystic                  | 2     1  1     1  1  2  2  2  1  1  1  1  2  2  1  3  2  3  1  1  2  2  4|             
      Inflammation, Chronic Active         |                                                                         4|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                            3                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Epidermis, Hyperplasia               |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                      +  +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                    3                    3|             
      Hemorrhage                           |                1        2              2  2                 4            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|             
                                           | 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
      Hydrocephalus                        |                                                    3                    3|             
      Inflammation, Chronic Active         |                1                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                1                                                         |             
      Pigmentation                         |                1                                                         |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                         +                                                |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
      Hemorrhage                           |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  1     1  1     1  1     1        1           1     1        2  1     1|             
      Mineralization                       | 1  1  1        1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Necrosis                             |                                        4                                 |             
      Pigmentation                         | 1     1  1  1        1  1  1     1  1           1  1  1        1        1|             
      Alveolar Epithelium, Hyperplasia     |                   2        2                                             |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Focal, Squamous                 |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1     1  1  1        1  1  1     1  1           1  1  1        1        1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2     2            |             
      Keratin Cyst                         |                                                       X                  |             
      Thrombosis                           |                                              4                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2  3              2           2        2  1  3              1   |             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|             
                                           | 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Lens, Degeneration                   |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1        1     1  1     1  1  1  1     1     1  1  1  1|             
      Nephropathy                          | 2  2  2  2  2  2  2  2     2  2  2  2  2  1  2  2  3  1  3     2  1  1  2|             
      Medulla, Necrosis                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X     X                                               X   |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      X  X                          X  X  X     X  X  X   |     10     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X           X           X     X           X  X     X  X  X  X     X|     25     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                    X                     |      2     |
      Hematopoietic Cell Proliferation     |                               2                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation, Chronic Active         | 1     2     1     2     2  1  1     3     1     2  1     1  1  2  2  1  2|     34  1.4|
      Mixed Cell Focus                     |       X           X                       X        X     X  X  X  X     X|     18     |
      Necrosis                             |                                                                          |      2  2.0|
      Bile Duct, Cyst                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  3  2  2  1     2  3  2     2  2  3  3  2     2  1  2  2  2  1  2  1  2|     45  1.8|
      Hepatocyte, Degeneration, Cystic     | 1           1                                                            |      4  1.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|       1  3        1        1  2     2        3  1  1     1  1  1  1     1|     23  1.6|
      Portal, Fibrosis                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +                             +     +     +  +  +               |  14        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Inflammation, Chronic           |          3                             3           3  3  3               |     11  3.0|
      Fat, Mineralization                  |          1                             2              2                  |      8  1.5|
      Fat, Necrosis                        |          4                             4           4  4  4               |     11  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |       +  +                                +                    +  +     +|  13        |
      Foreign Body                         |       X  X                                X                    X  X     X|     13     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |       2                                   2                       2      |      9  1.9|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |    1                    2                       3              2        2|     13  1.5|
      Duct, Cyst                           |                                           2                              |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                         1                                         1  2   |      8  1.5|
      Basophilic Focus                     |       X        X  X                                      X  X  X  X  X   |     16  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                       X                  |      1     |
      Inflammation, Chronic Active         |    3     3                                                               |      4  2.8|
      Epithelium, Hyperkeratosis           |                                                                          |      2  2.0|
      Epithelium, Hyperplasia              |    2     2                                                               |      5  2.2|
      Epithelium, Ulcer                    |    4     4                                   4                           |      5  3.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                     2                                    |      1  2.0|
      Epithelium, Ulcer                    |                                                                          |      1  2.0|
      Glands, Ectasia                      | 1  1     1           1     1  1  1     1  1     1  1  1  1     1  1      |     34  1.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                                     1                                    |      1  1.0|
      Media, Mineralization                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2     2  2  2  2  2  1  2  1  3  2  2  2  2  2  1  2  2  2  2  2  2|     44  1.9|
      Inflammation, Chronic Active         |                   2                                                      |      1  2.0|
      Mineralization                       |                                     3                                    |      1  3.0|
      Atrium, Thrombosis                   |                               4                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |          2                                                               |      1  2.0|
      Atypia Cellular                      | 2                                                                        |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          | 1                    2                                            1      |     12  1.3|
      Hypertrophy                          |                                                                          |      2  1.0|
      Vacuolization Cytoplasmic            | 2  2     2  2        1     1  1  1  1  1     3     1  1                 1|     30  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2              2           2                    1              2     2|      8  1.9|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                                                          |      2  2.0|
      Pars Distalis, Hemorrhage            |                                     4                                    |      1  4.0|
      Pars Distalis, Hyperplasia           |    3              2  2  2              2           2  2              1   |     16  1.8|
      Pars Distalis, Inflammation,         |                                                                          |            |
          Suppurative                      |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Pars Distalis, Mineralization        |                                     2                                    |      1  2.0|
      Pars Intermedia, Cyst                |                         2                                                |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                    2     2               |      3  2.0|
      C-Cell, Hyperplasia                  |          2        1                    1  1              1        2     1|     17  1.2|
      Follicle, Cyst                       |             2                                                            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |       2                                                                  |      3  2.0|
      Inflammation, Chronic Active         |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    2        2           3|      7  2.4|
      Inflammation, Chronic Active         | 1  2  2  2  1  1  2  2  2  2     2  2  2  2  2  2  2  2  2  1  2  2  2  2|     49  1.9|
      Mineralization                       |             1                                                           1|      2  1.0|
      Duct, Ectasia                        | 3                    2                             2                     |      5  2.8|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                          3               |      1  3.0|
      Degeneration                         |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 2        2  2  1        1                       2  2     1  1  2  2     2|     21  1.7|
      Mineralization                       |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                    2                     |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Mineralization                       |    1  1     1  1  1  1  1     1  1     1  1  1  2  1  1  2  1  1  1  1  2|     42  1.1|
      Germinal Epithelium, Atrophy         |                         4                 3        4           4         |      4  3.8|
      Interstitial Cell, Hyperplasia       | 2        1              1        1  1        1                           |     10  1.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3  4     4     4  3  4  4     4  4     4  3  3        4                  |     29  3.6|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +        +        +        +              +              +   |  24        |
      Ectasia                              |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Deep Cervical, Ectasia               |             2        3                                                   |      3  2.3|
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |      3  2.0|
      Mediastinal, Ectasia                 | 3     2                       2                                      3   |      6  2.3|
      Mediastinal, Hyperplasia, Lymphoid   |       2                       2                                      2   |      7  2.3|
      Pancreatic, Ectasia                  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +|   2        |
      Ectasia                              |                                                                         3|      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                 2                        |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                               3                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                               3                                          |      3  3.7|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Cyst                                 |                                                                          |      1  4.0|
      Hyperplasia, Cystic                  | 1  1  1  2  2  2  1  2     2  1  2  2  1     1  2  2  2  2  2  2  2     2|     45  1.7|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                    4                     |      1  4.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                            3                                             |      3  3.0|
      Hemorrhage                           |                                     1                                    |      6  2.0|
      Hydrocephalus                        |                            3                    2                        |      4  2.8|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                     2                                    |      1  2.0|
      Mineralization                       |                                     1                                    |      1  1.0|
      Necrosis                             |    4                                3                                    |      3  2.7|
      Pigmentation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1     1           1           1           1     1  1     1  1  1  1  1  2|     26  1.1|
      Mineralization                       | 1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1|     45  1.0|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation                         | 1  1  1     1     1  1  1              1        1  1  1  1     1  1  1  1|     30  1.0|
      Alveolar Epithelium, Hyperplasia     | 3                    2  2        3                 1     2              2|      9  2.1|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Focal, Squamous                 |                                                                         1|      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1  1     1  2  1  1  1              1        1  1  1  1     1  1  1  1|     31  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Keratin Cyst                         |                                                                          |      1     |
      Thrombosis                           |                                                                          |      1  4.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                         1  2        3        2                           |     12  2.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +                                                        +               |   2        |
      Lens, Cataract                       |                                                          4               |      1  4.0|
      Lens, Degeneration                   | 4                                                                        |      1  4.0|
      Retina, Degeneration                 | 4                                                        4               |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Hydronephrosis                       |             2                                                            |      1  2.0|
      Mineralization                       |    1  1  1  1     1  1  1     1  1  3  1  1     1  1  1  1  1  1     1   |     38  1.1|
      Nephropathy                          | 1  2  2  3  3  1  2  2  2  2  1  2     1  1  1  3  2  1  2  2  1  2  1  2|     47  1.8|
      Medulla, Necrosis                    |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |             2                                                            |      1  2.0|
      Inflammation, Chronic Active         |             3                                                            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|             
                                           | 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                   X            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                            X                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X     X  X     X  X  X  X              X  X  X  X        X        X  X|             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                               1                                          |             
      Hepatodiaphragmatic Nodule           |                                                                      X   |             
      Inflammation, Chronic Active         | 1  2  1  2  2     1  1  1  1  1  1  1     1  2  2  2  2     1        2  1|             
      Mixed Cell Focus                     | X  X     X  X     X  X  X  X              X  X  X  X  X     X        X  X|             
      Necrosis                             |          2     3                                                         |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2  1  1  3  2     1  2  2  2  1  1     3  2  1  2  2  2  3  1  2  1  2   |             
      Hepatocyte, Degeneration, Cystic     |                               1              1           1           1   |             
      Hepatocyte, Hyperplasia              |                                                                2         |             
      Hepatocyte, Vacuolization Cytoplasmic| 1  2     3  1     1  1  1  1           3  1  1  1  1     2  1     2  1  1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +                                      +                              |             
      Fat, Inflammation, Chronic           |    3                                      3                              |             
      Fat, Mineralization                  |    1                                      2                              |             
      Fat, Necrosis                        |    4                                      4                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|             
                                           | 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +     +              +           +  +  +                    +   |             
      Foreign Body                         |          X     X                          X  X  X                    X   |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |          2                                                           2   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                                                                          |             
      Acinus, Atrophy                      | 1     1     1                    1     1  1  2  3  2     2  1  1         |             
      Duct, Cyst                           |       2                       2                    2                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2                        |             
      Basophilic Focus                     |          X  X     1     X                 1     X     X     X            |             
      Inflammation, Chronic Active         |                                                                         1|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               2        2                                 |             
      Epithelium, Hyperkeratosis           |                               3                                          |             
      Epithelium, Hyperplasia              |                               3        2                                 |             
      Epithelium, Ulcer                    |                                        4                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               2                                          |             
      Epithelium, Erosion                  |                                        2                 1        1      |             
      Epithelium, Ulcer                    |                               4                                          |             
      Glands, Ectasia                      | 1  1              1  1  1  1  1  1     1  1     1  1     1        1  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  2  2     2  2  2     2  2  2  2  2  2  3  2  2  2  2  2     2|             
      Atrium, Thrombosis                   |                2                                   3                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|             
                                           | 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          1                    1                                          |             
      Hyperplasia                          | 1  1                       1                 2                 1        1|             
      Hypertrophy                          |          2                                                     2         |             
      Necrosis                             |                2                                         2               |             
      Vacuolization Cytoplasmic            | 1  2  2  2                 1  4  1     3  1  1  1  1     1  1  1  1      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                      2                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                3         |             
      Pars Distalis, Cyst                  |                         2                    3                           |             
      Pars Distalis, Hyperplasia           |                      1     1     2                    2     1            |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 2  1        3           2              1     1  1              1     2   |             
      Follicle, Cyst                       |                      2                                                   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|             
                                           | 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse,      |                                                                          |             
          Suppurative                      |                                  4                                       |             
      Inflammation, Chronic Active         | 1  2  2  2  2     2  2  2  2  2        2  2  2  3  2  2  2  2  2  2  2  2|             
      Duct, Ectasia                        |                               2     3                       2  2        2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |    3  1  1  2     2        1  1  1  2  1  1  1     1              1     2|             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                                        1                             2   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          1  1  2  1  1  1  1  1  1  2  1  1  1  2  1  1  1  1  1        1|             
      Germinal Epithelium, Atrophy         |                                                    4                     |             
      Interstitial Cell, Hyperplasia       | 1     1                          1     1                          1     1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4     3        4  3           4  4     3        3     3  3  3  4  4  3  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +     +     +           +  +  +     +        +     +  +     +  +      |             
      Deep Cervical, Hyperplasia, Lymphoid |    2                                                                     |             
      Mediastinal, Ectasia                 |          2                    2  2              2     2        3         |             
      Mediastinal, Hyperplasia, Lymphoid   |                3           2  2  2              2     2                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               4                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2              2              4  2                                       |             
      Hyperplasia, Lymphoid                |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|             
                                           | 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Infarct                              |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  M  +  +|             
      Ectopic Parathyroid Gland            |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  2  1  1  1  1  1  1  1     1  2  1  2  1  3  1  2  1  1     2  2  1  2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    2                                               2                     |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |    2  2                                            2                     |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1  2  1  1     1  2  1  2  1  2        1  1  1  1  2     1        1  2|             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1        1  1|             
      Pigmentation                         | 1  1     1        1  1  1  1  1           1  1  1  1  1     1        1  1|             
      Alveolar Epithelium, Hyperplasia     |             1              3                 1                       2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|             
                                           | 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1     1        1  1  1  1  1  1        1  1  1  1  1     1        1  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                X         |             
      Inflammation, Chronic Active         |                               2                                2  2      |             
      Thrombosis                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2                    3                    3     1        1      |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Lens, Cataract                       |                                                    4                     |             
      Retina, Degeneration                 |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Cyst                                 |                                                    4                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |          1     1     1     1  1  1     1  1        1  1  1  1  1     1  1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 1  3  1  2  2     2  2  1  2  2  2     2  1  2  1  3  1  1  2  2  1  2  1|             
      Cortex, Medulla, Fibrosis            |                                                                          |             
      Cortex, Medulla, Pigmentation        |                                                                          |             
      Cortex, Medulla, Pelvis, Cyst        |                                                                          |             
      Medulla, Renal Tubule, Dilatation    |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      X        X                                          |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                         X     X                                          |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       3                  |      1  3.0|
      Basophilic Focus                     |                X     X     X  X     X  X  X           X  X  X     X      |     26     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                      X                                                   |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                               X                                          |      2     |
      Inflammation, Chronic Active         | 2  1           2  1  1  2  2  2     1  2  1        2  2  2  2     1  1  2|     38  1.5|
      Mixed Cell Focus                     |                X  X  X  X  X  X        X  X        X  X  X  X           X|     29     |
      Necrosis                             |                                  3              1        1               |      5  2.0|
      Pigmentation                         |                                     2                                    |      1  2.0|
      Bile Duct, Cyst                      |                                        2                                 |      1  2.0|
      Bile Duct, Hyperplasia               | 1  1  2  1  3  2  2  1  2  2  2  1  1  2  2  1     1  2  2  2  3  1  3  2|     46  1.8|
      Hepatocyte, Degeneration, Cystic     |                1  1                                            2         |      7  1.1|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic| 1  1  3  1  3  1  1  1  1  1  1     3  1  1  2     2  1  1              1|     37  1.4|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |          +                             +     +                           |   5        |
      Fat, Inflammation, Chronic           |                                                                          |      2  3.0|
      Fat, Mineralization                  |                                                                          |      2  1.5|
      Fat, Necrosis                        |                                                                          |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                         +        +     +  +           +     +            |  13        |
      Foreign Body                         |                         X        X     X  X           X     X            |     12     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                       2     2            |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                          X               |      1     |
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Pigmentation                         |                1                                                         |      1  1.0|
      Acinus, Atrophy                      | 1        1  1     4     2     2     1  2  1        2           1     2  1|     25  1.5|
      Duct, Cyst                           |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    2              1        1                                2            |      5  1.6|
      Basophilic Focus                     | X  X                    X  X  X     X  1              X  X  X           X|     19  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                              3                           |      3  2.3|
      Epithelium, Hyperkeratosis           |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                              2                           |      3  2.3|
      Epithelium, Ulcer                    |                                              4                           |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                              2                           |      2  2.0|
      Epithelium, Erosion                  |                                              1                           |      4  1.3|
      Epithelium, Ulcer                    |                                                                          |      1  4.0|
      Glands, Ectasia                      | 1  1  1     1  1  1  1     1  1        1  1  1     1     1  1     1  1  1|     34  1.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                                                                      1   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     46  2.0|
      Atrium, Thrombosis                   |                                  2                                       |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hyperplasia                          |                1  1                                      2               |      9  1.2|
      Hypertrophy                          |                                                                2         |      3  2.0|
      Necrosis                             |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            | 1     1  3  3  1     1              2        2           1     2  1      |     27  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2        2        3                 2                    2  2     2|      9  2.1|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |       2     2                                                            |      4  2.3|
      Pars Distalis, Hyperplasia           | 2     1  2     2     1                 2     1           1               |     13  1.5|
      Pars Intermedia, Cyst                |    1                       2                                             |      2  1.5|
      Pars Intermedia, Hyperplasia         |                   4                                                      |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      C-Cell, Hyperplasia                  |    1     1     1     1  2  2  2     1        2        1     1        3  1|     22  1.5|
      Follicle, Cyst                       |                      2                                                   |      2  2.0|
      Follicular Cell, Hyperplasia         | 1                                                              1     1   |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Diffuse,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  4.0|
      Inflammation, Chronic Active         | 2  2  2  2  2  2  2     2     2     1  4  2  2     2  2  2  2  2  2  2  2|     43  2.0|
      Duct, Ectasia                        |                               2           2                              |      7  2.1|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              2  3                       3|      3  2.7|
      Inflammation, Chronic Active         |       2     1  2              1     4     1     1           1            |     23  1.5|
      Mineralization                       |                                                                         2|      1  2.0|
      Epithelium, Hyperplasia              |                2                                                        2|      4  1.8|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       | 1  2        1  1  1  1  1  1  1        2  1  1     1  1  1  1  1     1   |     38  1.1|
      Germinal Epithelium, Atrophy         |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |       1                 1                                                |      8  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4  4  4  4  4  3     4  4        3  3  3  3     3        3     4  4  3  3|     33  3.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +        +        +                 +     +                 +   |  20        |
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |    2                       2                 2     2                     |     10  2.1|
      Mediastinal, Hyperplasia, Lymphoid   |    2                       2                 2     2                     |     10  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                        2                                 |      5  2.4|
      Hyperplasia, Lymphoid                |                4        2                                                |      2  3.0|
      Infarct                              |          4                                                               |      1  4.0|
      Necrosis                             |                                  2                                       |      1  2.0|
      Pigmentation                         |                                  3                                       |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|  44        |
      Ectopic Parathyroid Gland            |                                                                      2   |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 2  2  1  1  1  3  1     1  2  1  1  1  1  1  1  2  1  1  1  1  2  1  1  1|     47  1.4|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2  2.0|
      Hemorrhage                           |                                                 3                        |      1  3.0|
      Hydrocephalus                        |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                     +                                    |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1              2     2     1  1        1  1        1  1  1  1     1  1  1|     32  1.3|
      Mineralization                       | 1  1  1  1  1  1  1  1     1  1  1     1  1  1  1  1  1  1  1  1  1  1  1|     46  1.0|
      Pigmentation                         | 1  1  1        1  1  1     1  1     1  1  1        1  1  1  1  2  1  1  1|     35  1.0|
      Alveolar Epithelium, Hyperplasia     |                               2                       2  3        2     3|     10  2.1|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1  1        1  1  1     1  1     1  1  1        1  1  1  1  3  1  1  1|     36  1.1|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                      X                                                   |      2     |
      Inflammation, Chronic Active         |                      1                                                   |      4  1.8|
      Thrombosis                           |          3  4                                                            |      2  3.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                              1                           |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                              3                           |      1  3.0|
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Mineralization                       |    1        1  1     1  1  1  1     1     1  1        1  1  1  1  1     1|     31  1.0|
      Necrosis                             |          3                                                               |      1  3.0|
      Nephropathy                          | 2  1  2  2  2  2  2     2  2  2  1  1  2  2  2  1  2  2  2  2  2  1  2  1|     47  1.7|
      Cortex, Medulla, Fibrosis            |                3                                                         |      1  3.0|
      Cortex, Medulla, Pigmentation        |                3                                                         |      1  3.0|
      Cortex, Medulla, Pelvis, Cyst        |                3                                                         |      1  3.0|
      Medulla, Renal Tubule, Dilatation    |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|             
                                           | 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .312%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X           X  X                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X     X  X  X     X  X        X  X     X            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         | 1  2  2  2  2  2  2  2  1  1  3  2  3  2  2  1     2  2  2  2            |             
      Mixed Cell Focus                     | X  X  X  X     X  X  X     X  X  X     X  X        X  X  X  X            |             
      Necrosis                             |                                     3                                    |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  1  2  2  2  1  2     1  2  2     2  2  2  2  2  2  2  2  2     1  2|             
      Hepatocyte, Degeneration, Cystic     |                2                                                         |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic| 1  1  1  1        1  1     1  2  1     1  1        1  1  1  1        2   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +                                            +  +     +  +   |             
      Fat, Inflammation, Chronic           |             3                                               3            |             
      Fat, Mineralization                  |             2                                                            |             
      Fat, Necrosis                        |             4                                               4            |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +                       +        +     +           +        +            |             
      Foreign Body                         | X                                      X           X        X            |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           | 2                       4        2     2                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|             
                                           | 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .312%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Hepatocyte               |                                                                   2      |             
      Acinus, Atrophy                      | 1     1                    2     2                    1     2           3|             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Cyst                           |                2           2           3                    3  2         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     2                                   2|             
      Basophilic Focus                     | X     X     X        X                                      X            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                3         |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperkeratosis           |    3                                                              2      |             
      Epithelium, Hyperplasia              |    3                                                           2  2      |             
      Epithelium, Ulcer                    |                                                                4         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Erosion                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Epithelium, Necrosis                 |                                                                   2      |             
      Glands, Ectasia                      | 1  1  1        1  1  1  1  1           1     1  1  1  1  1     1  2  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2     2  2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             2     1                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|             
                                           | 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .312%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 1           1                                                            |             
      Hyperplasia                          | 2                 2  2        2        2  1           1                  |             
      Hypertrophy                          |                                  1                          1            |             
      Vacuolization Cytoplasmic            | 1     1        1     1  1     1  1  2  2     2        1     1     2  1  1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1           2              1        2     1                    2|             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                      2              2     3                              |             
      Pars Distalis, Hyperplasia           | 3        2  1                          2           3     3     2     1  1|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1  1                       1           1        1           1        2|             
      Follicle, Cyst                       |          2                                                        3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                           2                             2|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3                                                      |             
      Inflammation, Chronic Active         | 2  2  2  1  2  2  2  2     1  1  2  2  2  2  1  2  2  2  2  2  3  2  2  2|             
      Duct, Ectasia                        |                                                                      2  2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             2            |             
      Inflammation, Chronic Active         |                2     1  1     1        1  1  2  1     2     2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|             
                                           | 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .312%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  1  1     1  1  1  2     1  1  1  1     1  1  2  1  1  1  1  1  1  1  2|             
      Interstitial Cell, Hyperplasia       |                         1                    1                       1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        3  3  3                    4           4     3     3  4  4  4  4|             
      Myeloid Cell, Hyperplasia            |                         4                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                 +        +        +           +  +        +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Bronchial, Ectasia                   |                                     2                                    |             
      Bronchial, Hyperplasia, Lymphoid     |                                     2                                    |             
      Deep Cervical, Ectasia               |                   2                                                      |             
      Deep Cervical, Hyperplasia, Lymphoid |                   2                                                      |             
      Mediastinal, Ectasia                 | 2                          2                       2        2           3|             
      Mediastinal, Hyperplasia, Lymphoid   | 3                          2                       2        2            |             
      Mediastinal, Pigmentation            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  +  M  M  M  M  M|             
      Ectasia                              |                                                          3               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                      2                                                   |             
      Hematopoietic Cell Proliferation     | 2        2  2  2        3           2                                    |             
      Hyperplasia, Lymphoid                |             3                                                            |             
      Infarct                              |                                                                          |             
      Lymphoid Follicle, Depletion Cellular|                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|             
                                           | 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .312%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Ectopic Parathyroid Gland            |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  2  1  1  1  2  1  1  2  1     1  2        2  2     1  1  2  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                         3|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                              2                           |             
      Hemorrhage                           |                                                                   2  3   |             
      Hydrocephalus                        |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         | 1  1  3  1  1  2  1     1     1  1     1  1        1  1  1  1            |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |    1  1  1  1  1  1  1     1              1  1     1  1  1  1           1|             
      Thrombosis                           |                                     2                                    |             
      Alveolar Epithelium, Hyperplasia     | 2              2     2           1        2              2               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1  3  1  1  1  1  1     1              1  1     1  1  1  1           1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|             
                                           | 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .312%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Thrombosis                           |                                                 4                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                           2                              |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
      Cornea, Inflammation, Chronic Active |       3                                                                  |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Lens, Cataract                       |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                   3      |             
      Infarct                              |                                                                          |             
      Mineralization                       | 1     1  1  1        1  1  1  1  1  1     1  1  1  1  1           1      |             
      Nephropathy                          | 2  2  2  2  2  1  2  2  1  2  2  2  1  2  2  1  2  2  2  2  2  1  1  1  2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3|            |
                                           | 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    .312%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X           X           X                     |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X                                                                 X|      5     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |          X     X  X     X  X  X     X  X  X  X     X  X  X  X     X     X|     32     |
      Hepatodiaphragmatic Nodule           |                                                       X                  |      1     |
      Inflammation, Chronic Active         | 1  1     1     2  1     2  2  2  1  2     2  2     1  2  1  2     1     2|     38  1.7|
      Mixed Cell Focus                     | X        X     X  X        X  X  X  X  X  X  X     X  X  X        X     X|     32     |
      Necrosis                             |             2                                                            |      2  2.5|
      Thrombosis                           |             3                                                            |      1  3.0|
      Bile Duct, Hyperplasia               | 2     3  1     2  2  1  1  2  2  1  2  2  1  2  2  1  2  1  2  2  2  2  2|     45  1.8|
      Hepatocyte, Degeneration, Cystic     |                                     1                       1            |      3  1.3|
      Hepatocyte, Hyperplasia              |                                                 3                        |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic| 1        1  2  1  1  3     1  1  2  1  1  1  1     1  1  1  1     1  3  1|     36  1.2|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +           +           +                                                |   8        |
      Fat, Inflammation, Chronic           | 4                                                                        |      3  3.3|
      Fat, Mineralization                  | 3                                                                        |      2  2.5|
      Fat, Necrosis                        | 4                                                                        |      3  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3|            |
                                           | 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    .312%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Oral Mucosa                             |                   +     +  +     +     +                    +     +     +|  14        |
      Foreign Body                         |                   X     X  X     X     X                    X     X     X|     12     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                         2  1           1                          1     1|      9  1.8|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                       X                  |      2     |
      Inflammation, Chronic Active         |                                                                   2      |      1  2.0|
      Metaplasia, Hepatocyte               |                                                                          |      1  2.0|
      Acinus, Atrophy                      | 1     2  2  1  2  1                 2     1        1  1  2     2        1|     20  1.6|
      Acinus, Hyperplasia                  |                               2                       4                  |      2  3.0|
      Duct, Cyst                           |                                           2                       1      |      7  2.1|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2        1                                      1  1     1               |      7  1.4|
      Basophilic Focus                     |                   X                                X        X     X     X|     10     |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                 2                        |      1  2.0|
      Epithelium, Hyperkeratosis           |                                                                          |      2  2.5|
      Epithelium, Hyperplasia              |                                                                          |      3  2.3|
      Epithelium, Ulcer                    |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                       2        2         |      2  2.0|
      Epithelium, Erosion                  |                                                                2     1   |      2  1.5|
      Epithelium, Hyperplasia              |                                                       3                  |      1  3.0|
      Epithelium, Necrosis                 |                                                                          |      1  2.0|
      Glands, Ectasia                      | 1     1  1  1        1  1  1  1  1  1  1  1  1     2  1  1  1  1     1  1|     37  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3|            |
                                           | 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    .312%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1     1     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2|     46  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     | 1        1                          1                                    |      5  1.0|
      Hyperplasia                          | 2        1        2     1              2  1  2           2  2            |     16  1.7|
      Hypertrophy                          |                                                                          |      2  1.0|
      Vacuolization Cytoplasmic            |    2  1     3     2  3  1     1  1     2  1  2     2        2     1  3   |     30  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      2  2  2                 1  1  2        2     1      |     14  1.6|
      Thrombosis                           | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                     3  2                       2         |      6  2.3|
      Pars Distalis, Hyperplasia           |             2  1              3           2              1           3  2|     16  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       2  2  1  1  2              1     1  2        1     1     2     2   |     20  1.4|
      Follicle, Cyst                       |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3|            |
                                           | 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    .312%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Granuloma Sperm                      |             2  2           2                                            2|      6  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                  2                                       |      2  2.5|
      Inflammation, Chronic Active         | 2     3  2  2  2  2  2  2  2  2  2  1  2  2  2     1  2  1  2  2  2  2  2|     47  1.9|
      Duct, Ectasia                        |                            4     2                    2  2        2      |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 2              2  1        2  2  2           2        2     2  4         |     20  1.8|
      Mineralization                       |       2                                                                  |      1  2.0|
      Epithelium, Hyperplasia              |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                4         |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       | 1     1  2  2  1  1  2  1  1  1  1  1  2  1  1     1  1  1  1  1     2  2|     44  1.2|
      Interstitial Cell, Hyperplasia       |                                                                1         |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       4     4           4     3                 4        3     4     4  4|     21  3.6|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +  +     +     +     +  +        +  +  +  +  +  +  +  +  +     +  +|  28        |
      Ectasia                              |                                        4                                 |      1  4.0|
      Bronchial, Ectasia                   |                                                                          |      1  2.0|
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |      1  2.0|
      Deep Cervical, Ectasia               |                2                             2        2                  |      4  2.0|
      Deep Cervical, Hyperplasia, Lymphoid |                2                             2        2                  |      4  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3|            |
                                           | 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    .312%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mediastinal, Ectasia                 |                            2  3           2        3     2  2            |     11  2.3|
      Mediastinal, Hyperplasia, Lymphoid   |          2                 2  3           2              2  2            |     10  2.2|
      Mediastinal, Pigmentation            |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  +  M  M  M|   4        |
      Ectasia                              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                    3     4               |      2  3.5|
      Fibrosis                             |       2                                3                                 |      3  2.3|
      Hematopoietic Cell Proliferation     |             2           2        2                       2               |     10  2.1|
      Hyperplasia, Lymphoid                |                                                          3               |      2  3.0|
      Infarct                              |                                                                      2   |      1  2.0|
      Lymphoid Follicle, Depletion Cellular|                                        3                                 |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|  45        |
      Ectopic Parathyroid Gland            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 1  2  2  2  1     2  2     1  2  2  1  2  2  1     1  1     3  2  1  2   |     41  1.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                      4   |      1  4.0|
      Inflammation, Granulomatous          |                               4                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3|            |
                                           | 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    .312%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Skeletal Muscle                         |             +     +                                                      |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                             2            |      2  2.0|
      Hemorrhage                           |                      3                                         2         |      4  2.5|
      Hydrocephalus                        |                                                    2        2            |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Inflammation, Chronic Active         | 1        1     2  1     1  1  1        2  1  2     1  2  1  1     1      |     31  1.2|
      Mineralization                       | 1  1     1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     47  1.0|
      Pigmentation                         | 1              1  1     1  1  1  1  1  1  1        1  1  1  1  1  1  1   |     32  1.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                        2  2           2                 2|     10  1.9|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1              1  1     1  1  1  1  1  1  1        1  1  1  1  1  1  1   |     32  1.1|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                X                                                         |      1     |
      Inflammation, Chronic Active         |                2                                      2                  |      2  2.0|
      Thrombosis                           |       1                                                              2   |      3  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                         2                          3        3            |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   2        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3|            |
                                           | 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    .312%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Cornea, Inflammation, Suppurative    |                                  4                                       |      1  4.0|
      Lens, Cataract                       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  3.0|
      Infarct                              |                                                                      4   |      1  4.0|
      Mineralization                       | 1           1     1  1  1  1           1  1  1     1  1     1     1     1|     30  1.0|
      Nephropathy                          | 2  1     2  1  2  2  2  3  2  2  2  2  2  2  2  1  1  2  1  1  1  1  2  2|     49  1.7|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                2         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|             
                                           | 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .625%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                 X        X                 X  X         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |          X     X        X  X           X  X        X  X  X  X  X  X  X  X|             
      Eosinophilic Focus                   |                                                                         X|             
      Hematopoietic Cell Proliferation     |                                                    1  2                  |             
      Hepatodiaphragmatic Nodule           |                                  X                          X        X   |             
      Inflammation, Chronic Active         |          2     2        2  2     2  1  2  2     1  2  1  2  2  2  1  2  1|             
      Mixed Cell Focus                     |          X     X        X  X     X     X  X        X     X  X  X     X   |             
      Necrosis                             |                                                          2               |             
      Bile Duct, Hyperplasia               | 2        1  2  2  3  2  2  1  3  2  1  2  2  3  2  2  2  1  2  1  1  1  2|             
      Hepatocyte, Degeneration, Cystic     |                            1           1           1                    2|             
      Hepatocyte, Hyperplasia              |                      3                                                   |             
      Hepatocyte, Vacuolization Cytoplasmic|    2  1  1     1  3     1  1  1  1  2  2  1  2  2        2  1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +                                                           +     +   |             
      Fat, Inflammation, Chronic           |                                                                3     3   |             
      Fat, Mineralization                  |                                                                2     2   |             
      Fat, Necrosis                        |    4                                                           4     4   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +           +     +  +                 +              +  +     +|             
      Foreign Body                         |          X           X     X  X                 X                 X     X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|             
                                           | 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .625%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                      2        2                 2              2         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2     4  1     2  2  1              2     2  1     3        4  1        1|             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                2                                                         |             
      Duct, Cyst                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2        2        2            |             
      Basophilic Focus                     |          X                 X     X        X        X        X  X     X   |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                     2                                    |             
      Epithelium, Hyperkeratosis           |    2                                                                     |             
      Epithelium, Hyperplasia              |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Ectasia                      | 1  1  1  1     1  2  1  1  1  1  1  1  1  1              1  1        1  1|             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  2  2  2  2  1  2  2     2  2  2  2  2  2  2  2  2  2  2     2  2|             
      Mineralization                       |             1                       1                                    |             
      Atrium, Thrombosis                   |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      1                                                   |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|             
                                           | 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .625%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia                          |                   2  1     2     2                          2  2        1|             
      Hypertrophy                          |                                                                      2   |             
      Mineralization                       |                                                                          |             
      Necrosis                             |             2                                                            |             
      Vacuolization Cytoplasmic            | 1  3  1  1     2  3  1     1  2  1  1  1     1  1  1     2     1  1     1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2              2  3     3           1                 2   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                1           2                                             |             
      Pars Distalis, Hyperplasia           | 2        1     1  2        2           1           2  1     2  2        2|             
      Pars Intermedia, Cyst                |                               2                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                 2                        |             
      C-Cell, Hyperplasia                  |                1     1                 1  2           1  1     1         |             
      Follicle, Cyst                       |       2                                2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                         2|             
      Inflammation, Chronic Active         |                                  2                                      1|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2              2                                 |             
      Inflammation, Chronic Active         | 2  2  1  2     2  2  2  1  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2|             
      Duct, Ectasia                        |          2        2     4  2                    2                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|             
                                           | 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .625%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                   4     2        2  2  1     2  2  2     2        2     2|             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                1     2              2                 2              2   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  1  1  1     1  1  1  2  1  1  1           2     2  1     1  1     1  1|             
      Germinal Epithelium, Atrophy         |          4                             2     2                           |             
      Interstitial Cell, Hyperplasia       |       1           1                    1     1           1               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  4  3     4     4  4        3              4     3  4                 3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +           +  +     +  +           +     +  +  +        +|             
      Deep Cervical, Ectasia               |                            2        2                                    |             
      Deep Cervical, Hyperplasia, Lymphoid |                            2                                            3|             
      Mediastinal, Ectasia                 |          3     3                       2           2     2               |             
      Mediastinal, Hyperplasia, Lymphoid   |          3     2           2           3           2     2  2  3         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            3                                             |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2                 1                       2  3                  |             
      Hyperplasia, Lymphoid                |                            4                                             |             
      Infarct                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                                                    2     2               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|             
                                           | 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .625%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  2  2  2  1  1  2  1  1     2  1  3  2  2  1  2  2     3  1  2  2  1  1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Dermis, Fibrosis                     |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Hair Follicle, Sebaceous Gland,      |                                                                          |             
          Atrophy                          |                                                                          |             
      Subcutaneous Tissue, Mineralization  |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     4                             2      |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                     2           2                 3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             3            |             
      Inflammation, Chronic Active         |          2     1        1  1     1  1  1        2  1  2  1  1  1     1  1|             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |          1     1        1  1     1  1  1  1        1     1  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     |                                  1     2                    1        4  2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          1     1        1  1     1  1  1  1        1     1  1  1  1  1  1|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|             
                                           | 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .625%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                            X              X                             X|             
      Inflammation, Chronic Active         |                                     2                                   2|             
      Thrombosis                           |                   4           3              4                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   1              2              2                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Lens, Cataract                       | 4                                                                        |             
      Retina, Degeneration                 | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                              2                           |             
      Mineralization                       | 1        1     1        1  1     1  1  1           1  1  1  1  1     1  1|             
      Nephropathy                          | 2     2  2     2  1  1  1  2  1  2  2  3  2  1  2  2  1  3  2  2  1  2  2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4|            |
                                           | 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    .625%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             X                                                            |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      X           X                                   X   |      8     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   2      |      1  2.0|
      Basophilic Focus                     |          X           X  X        X     X     X     X              X  X   |     23     |
      Eosinophilic Focus                   |                                                             X            |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Hepatodiaphragmatic Nodule           |                      X                                               X   |      5     |
      Inflammation, Chronic Active         | 1        1     1  2  2  1        2     2     1  1  2        2     1  1   |     31  1.6|
      Mixed Cell Focus                     |          X           X  X        X     X     X     X              X      |     20     |
      Necrosis                             |       2                             1                                    |      3  1.7|
      Bile Duct, Hyperplasia               | 2  1  2  1  3     1  1  2  3  3  2  2  2     2     2        2  2  2  1  2|     43  1.9|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      4  1.3|
      Hepatocyte, Hyperplasia              |                                                                   2      |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic| 2     3  1  1  2        1        1     1  3     1  1           3         |     32  1.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +  +        +  +                 +           +                  |   9        |
      Fat, Inflammation, Chronic           |          4  3        3  3                                                |      6  3.2|
      Fat, Mineralization                  |          1  1        2                                                   |      5  1.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4|            |
                                           | 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    .625%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis                        |          4  4        4  4                 4                              |      8  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                      +     +     +        +                              |  12        |
      Foreign Body                         |                      X     X     X                                       |     10     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                      2     3                                             |      6  2.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |       1  2        1  1     2  1        1     2              4  2         |     23  1.9|
      Acinus, Hyperplasia                  |                   3                                                      |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Duct, Cyst                           |       2           1           2                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1                                      1              1            |      6  1.5|
      Basophilic Focus                     |          X  X        X  X     X        X     X                    X  X  X|     18     |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Epithelium, Hyperkeratosis           |                               2                       2                  |      3  2.0|
      Epithelium, Hyperplasia              |                               3                       2                  |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Ectasia                      |    1     1           1     1  1  1           1     1  1                  |     27  1.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2        2  2  2  2  3|     45  2.0|
      Mineralization                       |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4|            |
                                           | 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    .625%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Angiectasis                          |                                                                         2|      1  2.0|
      Hematopoietic Cell Proliferation     |             1                                                            |      2  1.0|
      Hyperplasia                          |          2        2              2     2     2                    1  1   |     14  1.7|
      Hypertrophy                          |                                                                          |      1  2.0|
      Mineralization                       |          2                                                               |      1  2.0|
      Necrosis                             |                            2                                   1         |      3  1.7|
      Vacuolization Cytoplasmic            |       3  2     3  2  1  1           1     2  1        3     1  1     1  1|     33  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   3                    3                                 |      8  2.4|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                                                   1      |      3  1.3|
      Pars Distalis, Hyperplasia           |          1           1     1        2  2           2              2      |     18  1.6|
      Pars Intermedia, Cyst                |       2                                                                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                         2                                                |      2  2.0|
      C-Cell, Hyperplasia                  |       1              1        1  1                 1        1     1  1   |     15  1.1|
      Follicle, Cyst                       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4|            |
                                           | 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    .625%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                              +                           |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                         2     2  2                                       |      4  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Chronic Active         | 1  1  2  2  4        2  2  1  2  2  2  2     2     2  2     2  1  3  2  2|     43  1.9|
      Duct, Ectasia                        | 2                                                                        |      6  2.3|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                             2            |      1  2.0|
      Inflammation, Chronic Active         | 2     2           2     2  1              1        1              2  1   |     20  1.9|
      Mineralization                       |                                                       2                  |      1  2.0|
      Epithelium, Hyperplasia              |       2              2                                               2   |      8  1.9|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |       2  1  2  1     1  1  1  1  1  1  1  1  1     1  1     1  1        1|     36  1.1|
      Germinal Epithelium, Atrophy         |                                                                          |      3  2.7|
      Interstitial Cell, Hyperplasia       | 1                 1                                                      |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3  4     3  4     3     4  3     4     4        3  4        4  4  4  4|     26  3.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +     +     +  +  +  +     +  +  +  +        +  +           +     +|  28        |
      Deep Cervical, Ectasia               |             2                          2                                 |      4  2.0|
      Deep Cervical, Hyperplasia, Lymphoid |                   2                    3                                 |      4  2.5|
      Mediastinal, Ectasia                 |       3              3  2        2                 2              2      |     11  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4|            |
                                           | 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    .625%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mediastinal, Hyperplasia, Lymphoid   |                      3  2        2                 2                     |     12  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Ectasia                              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Infarct                              |                                           4                              |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Ectopic Parathyroid Gland            |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 4  2  2  2  1     3  1  1  2  1  2  2  2  2  1     1  1     1  1  1  1  2|     45  1.6|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
      Dermis, Fibrosis                     | 4                                                                        |      1  4.0|
      Epidermis, Hyperplasia               | 2                                                                        |      1  2.0|
      Hair Follicle, Sebaceous Gland,      |                                                                          |            |
          Atrophy                          | 4                                                                        |      1  4.0|
      Subcutaneous Tissue, Mineralization  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4|            |
                                           | 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    .625%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                   3                                                      |      3  3.0|
      Hemorrhage                           |                                     4           2                        |      2  3.0|
      Hydrocephalus                        | 2                 3                                                      |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |          2        1  1  1     1  1     1     1  1        3  1        1   |     27  1.2|
      Metaplasia, Osseous                  |                            2                                             |      1  2.0|
      Mineralization                       | 1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1|     48  1.0|
      Pigmentation                         | 1           1     1     1        1           1     1                 1   |     23  1.0|
      Alveolar Epithelium, Hyperplasia     |          2                             1                    2        2   |      9  1.9|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1           1     1     1        1     1     1     1                 1   |     24  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                  X                                       |      4     |
      Inflammation, Chronic Active         |                   1                                                      |      3  1.7|
      Thrombosis                           |                4           2                                   4         |      6  3.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   1                       2                              |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4|            |
                                           | 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    .625%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                            4                                             |      2  3.0|
      Mineralization                       | 1  1  1  1  1     1  1  1  1  1        1     1     1        1  1  1     1|     32  1.0|
      Nephropathy                          | 1  2  2  2  1     2  1  2  2  1  2  1  2     2  1  2        2  1  2  2  1|     44  1.7|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|             
                                           | 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X     X     X  X  X  X  X     X  X     X  X     X     X  X     X|             
      Clear Cell Focus                     | X                          X                          X                  |             
      Hepatodiaphragmatic Nodule           |                                                                X         |             
      Inflammation, Chronic Active         | 2        2  2  1  2  1  2  1  2  1  1  2  1     2  2  1  2     2  2     1|             
      Mixed Cell Focus                     | X        X     X  X  X  X  X     X     X        X  X  X  X     X  X     X|             
      Necrosis                             |    2                                                                     |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  2  2  1  2  1     2  1  1  2  2  2  2     2  2     2|             
      Hepatocyte, Degeneration, Cystic     |                1  1                    1                                 |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Hypertrophy              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|          1     1  1  1  1  1  1     2  1     2  1  1  1  1     2  1     2|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                   +     +     +                       +              +   |             
      Fat, Inflammation, Chronic           |                   3     2                             3                  |             
      Fat, Mineralization                  |                         2                                                |             
      Fat, Necrosis                        |                   4     4                             4                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +     +  +                    +  +           +           +     +     +   |             
      Foreign Body                         | X        X                    X  X                       X     X     X   |             
      Gingival, Inflammation, Chronic      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|             
                                           | 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
          Active                           | 2     2  2                       1           3           1               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             
      Acinus, Atrophy                      |             1        2                    2                       3     1|             
      Duct, Cyst                           |          2                                         2           2  2     2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                                            |             
      Basophilic Focus                     | X        X  X     X     1     X        X           X           X  X     X|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2                                                                     |             
      Mineralization                       |                                           2                              |             
      Epithelium, Erosion                  |                                     3                                    |             
      Epithelium, Ulcer                    |    4                                                                     |             
      Glands, Ectasia                      | 1  1  1  1     1  1  1     1     1  1  1  1  1  1  1  1  2  1  1  1     1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                           2                              |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2  2  2  2  2  1  1  2  2  1  2  1  2  1  2  2  2  2|             
      Mineralization                       |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                2                 2                                       |             
      Hematopoietic Cell Proliferation     |                               1                       1  1               |             
      Hyperplasia                          |                2  2  2  2        4              1  1     2        1      |             
      Hypertrophy                          |                                                    1                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|             
                                           | 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Necrosis                             |    2                                                                     |             
      Vacuolization Cytoplasmic            | 2  1  1  1  2  2  2  1              3  1  2  3     1        4  1  1     2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         2                                                |             
      Pars Distalis, Cyst                  |                                        2        1                        |             
      Pars Distalis, Hyperplasia           |    2  1     1                 2  1     2     2  1        1     1  2      |             
      Pars Intermedia, Angiectasis         |                         3                                                |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |             2                                                            |             
      C-Cell, Hyperplasia                  | 2  1           2  1  1     1     2  1     2        1           2  1     1|             
      Follicle, Cyst                       |             2              2                                             |             
      Follicular Cell, Hyperplasia         |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                            2     2                                2      |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                       3                                2         |             
      Inflammation, Chronic Active         | 2  2  1  2  2  2  2     2  2  2  2  2  1  2  2  2  2  1  2  2  2  2  1  2|             
      Mineralization                       |                            1                                             |             
      Duct, Ectasia                        |       3                    2                                         2   |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|             
                                           | 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 |                      3                                                   |             
      Inflammation, Chronic Active         |    1     2     1     1                 1  4        2        1            |             
      Epithelium, Hyperplasia              |          1                    2                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               3                                          |             
      Mineralization                       | 1  1     1  1  1  1  1  2  1     2  1     1     1  1  1  1        1  2  1|             
      Germinal Epithelium, Atrophy         |                                           3                              |             
      Interstitial Cell, Hyperplasia       |    1                                      1                 1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4  4     4        4        3     4        3  3     3     3  3         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +        +  +     +  +        +     +              +           +     +   |             
      Deep Cervical, Ectasia               |                                     3                                    |             
      Deep Cervical, Hyperplasia, Lymphoid |                                     2                                    |             
      Mediastinal, Ectasia                 | 2           2     2           2                                          |             
      Mediastinal, Hyperplasia, Lymphoid   | 2        2  2     2  3        2                    3           2         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                          2               |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3     3                                               2            |             
      Hyperplasia, Lymphoid                |                   3        2  3                       2                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +|             
      Ectopic Parathyroid Gland            |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|             
                                           | 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Hyperplasia, Cystic                  | 1  1  2  2  2  2  2  1  1  1  1  1     2  2     1  2  2  2  1  2  2     2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                    2                     |             
      Thrombosis                           |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          2                                                     1         |             
      Inflammation, Chronic Active         | 1        2  2  1  1  1  1  1     1     2     1  1  1  1  1  1  1  1     1|             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         | 1     1  1  1     1     1  1  1     1  1  1  1  1  1  1     1  1  1      |             
      Alveolar Epithelium, Hyperplasia     |          2  3     2     2                 2              2     1         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1     1  1  1     1     1  1  1     1  1  1  1  1  1  1     1  1  1      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         X                                X  X            |             
      Inflammation, Chronic Active         |                         3                    2           1  3            |             
      Polyp Inflammatory                   |                                                                          |             
      Thrombosis                           |    4                                                                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       2           2           2        2     2     2  2                  |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|             
                                           | 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                      +              +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           4                              |             
      Cyst                                 |                                           2                              |             
      Inflammation, Suppurative            |             2                                                            |             
      Metaplasia, Osseous                  |                                           3                              |             
      Mineralization                       |    1  1  1     1  1  1  1  1  1  1  1  1  2  1  1  1     1     1  1     1|             
      Necrosis                             |    3                                                                     |             
      Nephropathy                          | 2     1  2  2  2  2  2  1  2  2  2     2  4  2  2  2  1  1  3  2  1     2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 122                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                   X      |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X  X                          X                          X         |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X     X     X  X  X     X  X  X  X  X  X  X     X  X        X   |     33     |
      Clear Cell Focus                     |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                                        X                    X     X      |      4     |
      Inflammation, Chronic Active         | 1  1     2           1  2  2  1  2  1  1  1  2  1  2     2  2  1     1  2|     39  1.5|
      Mixed Cell Focus                     | X  X           X     X  X  X  X  X     X  X  X  X  X     X  X           X|     32     |
      Necrosis                             |                   2     1                             2                 1|      5  1.6|
      Bile Duct, Hyperplasia               | 2  2  1  2  2        2  1  2  1  2  2  1  1  2  1  1     2  2  2     1  1|     43  1.7|
      Hepatocyte, Degeneration, Cystic     |       1                 1                                                |      5  1.0|
      Hepatocyte, Hyperplasia              |             4                                                            |      1  4.0|
      Hepatocyte, Hypertrophy              |             2                                                            |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic| 1  1  1              1  1  1  1  1           1  1  1  3  1  1  1     1  2|     34  1.2|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +        +     +        +     +        +                 +               |  12        |
      Fat, Inflammation, Chronic           | 3        3     3              3        2                 3               |      9  2.8|
      Fat, Mineralization                  | 1                       1     2        2                 1               |      6  1.5|
      Fat, Necrosis                        | 4        4     4        4     4        4                 4               |     10  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 123                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +     +              +  +        +  +  +  +  +  +  +        +  +  +  +   |  24        |
      Foreign Body                         | X     X              X  X        X  X  X  X  X  X  X        X  X  X  X   |     22     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |       1                 2           2  2  1  1                           |     12  1.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Acinus, Atrophy                      | 1  1        3              2     3  2        2  2           2        2  4|     16  2.1|
      Duct, Cyst                           |             3  3                 2  3     2                              |     10  2.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Basophilic Focus                     |    X  X     X        X  X     X  X        X     X  X     X     X     X   |     24  1.0|
      Inflammation, Chronic Active         |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                                   2      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Epithelium, Erosion                  |                                                                          |      1  3.0|
      Epithelium, Ulcer                    |                                                                          |      1  4.0|
      Glands, Ectasia                      | 1  1        1        1  1  1  1  1  1  1  1  1  1  1  1  1  1        1   |     39  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  1  2  1  2  1  2  1  1  2  2|     50  1.8|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 124                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                         1                             1     1           1|      7  1.0|
      Hyperplasia                          |                1        2                                      2        1|     13  1.8|
      Hypertrophy                          |       1                                                                  |      2  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 1        2           1                                3           1  2  1|     24  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3                                3                          2        1   |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                       2              2   |      4  1.8|
      Pars Distalis, Hyperplasia           | 2              3     3  2  3  1                 2        2        3  2   |     21  1.9|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                          2               |      2  2.0|
      C-Cell, Hyperplasia                  |    2     1  1           1                    3     2     2  3  2  2      |     23  1.6|
      Follicle, Cyst                       |       3                                                                  |      3  2.3|
      Follicular Cell, Hyperplasia         |                                                 1                        |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 125                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                         2     2                                          |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      3  2.3|
      Inflammation, Chronic Active         | 2  2  2  2  2  2  2  2  2  1  2  2  2  2  1  1  2  2  2  2  2  2  2  2  2|     49  1.9|
      Mineralization                       |                                                                          |      1  1.0|
      Duct, Ectasia                        |    3     2           3        2        2              2                  |      9  2.3|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |    2     2  2           2                       1  1                    1|     15  1.6|
      Epithelium, Hyperplasia              |             2           2                          2                    2|      6  1.8|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Mineralization                       | 1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1     1  2  1  1  2     1|     41  1.1|
      Germinal Epithelium, Atrophy         |                                                                      3   |      2  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             4  3  4  3              4  3              4     3  4  3  3   |     22  3.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +        +     +           +     +           +  +        +  +         |  20        |
      Deep Cervical, Ectasia               |                                                    2                     |      2  2.5|
      Deep Cervical, Hyperplasia, Lymphoid | 2                                                  2                     |      3  2.0|
      Mediastinal, Ectasia                 |    2                                            2           2            |      7  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |    2                          2                 2           3            |     12  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 126                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |             2                                                        2  2|      6  2.3|
      Hyperplasia, Lymphoid                |       2                                                                  |      5  2.4|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|  43        |
      Ectopic Parathyroid Gland            |                            2                                             |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 1  2  2  4  2  1  1  1  2  1  2  1  1  1  2  2  1  2  1  2  1  1  2  1  1|     47  1.6|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |          2                                                               |      1  2.0|
      Hemorrhage                           |                   2                                                      |      1  2.0|
      Hydrocephalus                        |          2                                                               |      2  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 127                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      2  1.5|
      Inflammation, Chronic Active         | 1  1     2     1     1  1  1  1  2  2  1  1  1  2  1     1        1      |     36  1.2|
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1|     49  1.0|
      Pigmentation                         |    1  1  1  1  1     1     1        1  1  1  1  1  1     1     1     1  1|     35  1.0|
      Alveolar Epithelium, Hyperplasia     |          2     2        1                       1                        |     11  1.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1  1  2  1  1     1     1        1  1  1  1  1  1     1     1     1  1|     35  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      3     |
      Inflammation, Chronic Active         |                                                                          |      4  2.3|
      Polyp Inflammatory                   |                                                          3               |      1  3.0|
      Thrombosis                           |                   4                                                      |      2  4.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                     2                          1         |      9  1.9|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Mineralization                       | 1  1  1        1  1  1  1  1  1  1  1  1              1     1  1  1  1  1|     38  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Nephropathy                          | 2  2  2  2  2  2     2  2  1  2  2  2  2  2  2  2  2     2  2  2  2  2  2|     45  1.9|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 128                                                               
                                                                                                                                   
NTP Experiment-Test: 56111-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 06/01/01    
Route: DOSED FEED                                                                                                 Time: 10:41:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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