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TDMS Study 56111-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 06/29/01       
EXPERIMENT: 56111 TEST: 03                                                                                     TIME: 08:39:18       
TEST TYPE:  CHRONIC                                                                                            PAGE:       1        
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 14371-10-9      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            Final#1/Rats                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 003    VEHICLE CONTROL                                                               
                                       INCLUDE 004    VEHICLE CONTROL                                                               
                                       INCLUDE 005    .312%                                                                         
                                       INCLUDE 006    .312%                                                                         
                                       INCLUDE 007    .625%                                                                         
                                       INCLUDE 008    .625%                                                                         
                                       INCLUDE 009    1.25%                                                                         
                                       INCLUDE 010    1.25%                                                                         
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 06/29/01       
EXPERIMENT: 56111 TEST: 03                                                                                     TIME: 08:39:18       
TEST TYPE:  CHRONIC                                                                                                                 
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 14371-10-9      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF               TRANS-CINNAMALDEHYDE                                                                               
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Eye: Retina                            Degeneration                                                                                 
Heart                                  Cardiomyopathy                                                                               
Kidney                                 Nephropathy                                                                                  
Liver                                  Inflammation Chronic                                                                         
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Lung                                   Fibrosis                                                                                     
                                       Pigmentation                                                                                 
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Mammary Gland                          Hyperplasia Cystic                                                                           
Mesentery: Fat                         Necrosis                                                                                     
Pancreas: Acinus                       Atrophy                                                                                      
Pancreas: Duct                         Cyst                                                                                         
Preputial Gland                        Inflammation Chronic                                                                         
Prostate                               Inflammation Chronic                                                                         
Salivary Glands                        Atrophy                                                                                      
                                       Basophilic Focus                                                                             
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Brain                                  Hemorrhage                                                                                   
Clitoral Gland                         Inflammation Chronic                                                                         
Clitoral Gland: Duct                   Cyst                                                                                         
Intestine Large, Colon                 Parasite Metazoan                                                                            
Kidney                                 Mineralization                                                                               
Liver                                  Hepatodiaphragmatic Nodule                                                                   
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Mammary Gland                          Hyperplasia Cystic                                                                           
Oral Mucosa                            Foreign Body                                                                                 
Oral Mucosa: Gingival                  Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
Pancreas: Duct                         Cyst                                                                                         
Salivary Glands                        Atrophy                                                                                      
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.64      2/45.17      1/39.67      2/47.85     |2/45.91      1/44.73      0/42.98      1/44.31      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.5%         4.2%        |4.4%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/31 (0%)    2/36 (6%)    1/27 (4%)    2/41 (5%)   |2/36 (6%)    1/33 (3%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          731 (T)      731 (T)      731 (T)     |735 (T)      735 (T)      ---          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.320      P=0.272      P=0.472      P=0.302     |P=0.382N     P=0.530N     P=0.244N     P=0.523N     | 
|POLY 3             |     P=0.295      P=0.256      P=0.490      P=0.270     |P=0.372N     P=0.509N     P=0.252N     P=0.512N     | 
|POLY 1.5           |     P=0.274      P=0.246      P=0.492      P=0.256     |P=0.371N     P=0.507N     P=0.250N     P=0.509N     | 
|POLY 6             |     P=0.323      P=0.268      P=0.487      P=0.287     |P=0.371N     P=0.513N     P=0.252N     P=0.516N     | 
|LOGISTIC REGRESSION|     (e)          P=0.272      P=0.472      P=0.302     |P=0.380N     P=0.530N     (e)          P=0.516N     | 
|COCH-ARM / FISHERS |     P=0.246      P=0.247      P=0.500      P=0.247     |P=0.367N     P=0.500N     P=0.253N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   2/50 (4%)    7/50 (14%)  |1/50 (2%)    5/50 (10%)   2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/41.64      5/45.17      2/39.67      7/48.07     |1/45.91      5/45.24      2/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     4.8%         11.1%        5.0%         14.6%       |2.2%         11.1%        4.7%         2.3%         | 
|TERMINAL (d)       |     2/31 (7%)    5/36 (14%)   2/27 (7%)    6/41 (15%)  |1/36 (3%)    3/33 (9%)    2/35 (6%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      731 (T)      672         |735 (T)      652          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.158      P=0.278      P=0.645      P=0.169     |P=0.372N     P=0.091      P=0.490      P=0.742      | 
|POLY 3             |     P=0.109      P=0.250      P=0.677      P=0.119     |P=0.366N     P=0.098      P=0.477      P=0.752      | 
|POLY 1.5           |     P=0.094      P=0.233      P=0.680      P=0.101     |P=0.360N     P=0.098      P=0.480      P=0.754      | 
|POLY 6             |     P=0.130      P=0.272      P=0.671      P=0.144     |P=0.372N     P=0.097      P=0.476      P=0.749      | 
|LOGISTIC REGRESSION|     P=0.152      P=0.278      P=0.645      P=0.151     |P=0.361N     P=0.099      P=0.490      P=0.742      | 
|COCH-ARM / FISHERS |     P=0.079      P=0.218      P=0.691N     P=0.080     |P=0.344N     P=0.102      P=0.492      P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   16/50 (32%)  14/50 (28%)  13/50 (26%) |17/50 (34%)  9/50 (18%)   12/49 (24%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     9/42.63      16/45.17     14/40.43     13/47.85    |17/46.54     9/44.73      12/44.17     10/45.36     | 
|POLY-3 PERCENT (g) |     21.1%        35.4%        34.6%        27.2%       |36.5%        20.1%        27.2%        22.0%        | 
|TERMINAL (d)       |     6/31 (19%)   16/36 (44%)  11/27 (41%)  13/41 (32%) |14/36 (39%)  9/33 (27%)   9/35 (26%)   6/33 (18%)   | 
|FIRST INCIDENCE    |     577          731 (T)      627          731 (T)     |652          735 (T)      498          590          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.472N     P=0.160      P=0.103      P=0.489     |P=0.179N     P=0.084N     P=0.229N     P=0.144N     | 
|POLY 3             |     P=0.472      P=0.103      P=0.125      P=0.336     |P=0.134N     P=0.063N     P=0.232N     P=0.095N     | 
|POLY 1.5           |     P=0.411      P=0.090      P=0.137      P=0.292     |P=0.136N     P=0.061N     P=0.229N     P=0.095N     | 
|POLY 6             |     P=0.548      P=0.120      P=0.111      P=0.392     |P=0.128N     P=0.070N     P=0.227N     P=0.095N     | 
|LOGISTIC REGRESSION|     P=0.521N     P=0.153      P=0.125      P=0.401     |P=0.155N     P=0.069N     P=0.243N     P=0.104N     | 
|COCH-ARM / FISHERS |     P=0.332      P=0.083      P=0.171      P=0.235     |P=0.133N     P=0.055N     P=0.207N     P=0.088N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |4/50 (8%)    2/50 (4%)    3/49 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/42.09      2/45.17      1/39.67      2/47.85     |4/45.91      2/45.20      3/42.98      2/44.16      | 
|POLY-3 PERCENT (g) |     7.1%         4.4%         2.5%         4.2%        |8.7%         4.4%         7.0%         4.5%         | 
|TERMINAL (d)       |     2/31 (7%)    2/36 (6%)    1/27 (4%)    2/41 (5%)   |4/36 (11%)   1/33 (3%)    3/35 (9%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     598          731 (T)      731 (T)      731 (T)     |735 (T)      597          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.321N     P=0.438N     P=0.348N     P=0.386N    |P=0.347N     P=0.371N     P=0.516N     P=0.377N     | 
|POLY 3             |     P=0.380N     P=0.468N     P=0.326N     P=0.442N    |P=0.336N     P=0.344N     P=0.536N     P=0.355N     | 
|POLY 1.5           |     P=0.391N     P=0.484N     P=0.321N     P=0.466N    |P=0.331N     P=0.345N     P=0.530N     P=0.350N     | 
|POLY 6             |     P=0.367N     P=0.448N     P=0.335N     P=0.413N    |P=0.340N     P=0.346N     P=0.537N     P=0.361N     | 
|LOGISTIC REGRESSION|     P=0.349N     P=0.474N     P=0.321N     P=0.475N    |P=0.340N     P=0.344N     P=0.516N     P=0.377N     | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.500N     P=0.309N     P=0.500N    |P=0.320N     P=0.339N     P=0.511N     P=0.339N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.04      0/45.17      3/40.47      1/48.20     |1/46.16      2/45.69      1/43.40      1/44.70      | 
|POLY-3 PERCENT (g) |     4.8%         0.0%         7.4%         2.1%        |2.2%         4.4%         2.3%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    1/27 (4%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     647          ---          609          633         |670          561          613          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476N     P=0.203N     P=0.468      P=0.405N    |P=0.550N     P=0.497      P=0.737      P=0.747      | 
|POLY 3             |     P=0.518N     P=0.221N     P=0.483      P=0.453N    |P=0.542N     P=0.497      P=0.747      P=0.754      | 
|POLY 1.5           |     P=0.532N     P=0.229N     P=0.485      P=0.472N    |P=0.539N     P=0.496      P=0.749      P=0.755      | 
|POLY 6             |     P=0.501N     P=0.212N     P=0.477      P=0.429N    |P=0.545N     P=0.496      P=0.747      P=0.751      | 
|LOGISTIC REGRESSION|     P=0.589N     P=0.241N     P=0.504      P=0.621N    |P=0.484N     P=0.588      P=0.729N     P=0.708N     | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.247N     P=0.500      P=0.500N    |P=0.531N     P=0.500      P=0.747      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  30/50 (60%)  33/50 (66%)  24/50 (48%) |18/50 (36%)  25/50 (50%)  19/49 (39%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     27/47.35     30/49.35     33/46.21     24/49.69    |18/46.75     25/46.90     19/44.46     20/45.57     | 
|POLY-3 PERCENT (g) |     57.0%        60.8%        71.4%        48.3%       |38.5%        53.3%        42.7%        43.9%        | 
|TERMINAL (d)       |     13/31 (42%)  19/36 (53%)  16/27 (59%)  17/41 (42%) |13/36 (36%)  18/33 (55%)  14/35 (40%)  14/33 (42%)  | 
|FIRST INCIDENCE    |     499          170          488          499         |679          597          459          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.079N     P=0.500N     P=0.127      P=0.089N    |P=0.457      P=0.079      P=0.451      P=0.319      | 
|POLY 3             |     P=0.186N     P=0.433      P=0.103      P=0.255N    |P=0.499      P=0.106      P=0.421      P=0.376      | 
|POLY 1.5           |     P=0.216N     P=0.400      P=0.107      P=0.288N    |P=0.514      P=0.103      P=0.430      P=0.386      | 
|POLY 6             |     P=0.157N     P=0.463      P=0.101      P=0.224N    |P=0.483      P=0.107      P=0.420      P=0.364      | 
|LOGISTIC REGRESSION|     P=0.329N     P=0.238      P=0.150      P=0.582N    |P=0.504      P=0.094      P=0.407      P=0.356      | 
|COCH-ARM / FISHERS |     P=0.265N     P=0.343      P=0.154      P=0.345N    |P=0.523N     P=0.113      P=0.469      P=0.418      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   14/50 (28%)  8/50 (16%)   5/50 (10%)  |6/50 (12%)   3/50 (6%)    3/49 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     9/42.82      14/46.41     8/39.85      5/47.85     |6/45.91      3/44.88      3/43.11      3/44.31      | 
|POLY-3 PERCENT (g) |     21.0%        30.2%        20.1%        10.5%       |13.1%        6.7%         7.0%         6.8%         | 
|TERMINAL (d)       |     7/31 (23%)   10/36 (28%)  7/27 (26%)   5/41 (12%)  |6/36 (17%)   2/33 (6%)    2/35 (6%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     505          591          682          731 (T)     |735 (T)      697          702          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.025N*    P=0.296      P=0.601      P=0.086N    |P=0.246N     P=0.282N     P=0.255N     P=0.283N     | 
|POLY 3             |     P=0.037N*    P=0.228      P=0.566N     P=0.135N    |P=0.233N     P=0.253N     P=0.274N     P=0.259N     | 
|POLY 1.5           |     P=0.048N*    P=0.196      P=0.547N     P=0.158N    |P=0.230N     P=0.252N     P=0.270N     P=0.255N     | 
|POLY 6             |     P=0.026N*    P=0.275      P=0.592N     P=0.110N    |P=0.234N     P=0.256N     P=0.272N     P=0.263N     | 
|LOGISTIC REGRESSION|     P=0.040N*    P=0.192      P=0.551N     P=0.158N    |P=0.243N     P=0.273N     P=0.266N     P=0.273N     | 
|COCH-ARM / FISHERS |     P=0.068N     P=0.171      P=0.500N     P=0.194N    |P=0.222N     P=0.243N     P=0.254N     P=0.243N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  21/50 (42%)  26/50 (52%)  22/50 (44%) |16/50 (32%)  13/50 (26%)  11/49 (22%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     33/49.34     21/47.29     26/45.94     22/49.51    |16/48.78     13/47.81     11/46.30     13/47.06     | 
|POLY-3 PERCENT (g) |     66.9%        44.4%        56.6%        44.4%       |32.8%        27.2%        23.8%        27.6%        | 
|TERMINAL (d)       |     16/31 (52%)  12/36 (33%)  10/27 (37%)  16/41 (39%) |6/36 (17%)   3/33 (9%)    3/35 (9%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     429          593          506          499         |523          561          459          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.020N*    P=0.011N*    P=0.307N     P=0.005N**  |P=0.387N     P=0.410N     P=0.264N     P=0.422N     | 
|POLY 3             |     P=0.043N*    P=0.019N*    P=0.204N     P=0.018N*   |P=0.340N     P=0.353N     P=0.227N     P=0.372N     | 
|POLY 1.5           |     P=0.046N*    P=0.018N*    P=0.180N     P=0.019N*   |P=0.331N     P=0.352N     P=0.222N     P=0.362N     | 
|POLY 6             |     P=0.041N*    P=0.020N*    P=0.226N     P=0.017N*   |P=0.347N     P=0.354N     P=0.229N     P=0.380N     | 
|LOGISTIC REGRESSION|     P=0.082N     P=0.020N*    P=0.091N     P=0.168N    |P=0.236N     P=0.268N     P=0.105N     P=0.244N     | 
|COCH-ARM / FISHERS |     P=0.057N     P=0.013N*    P=0.111N     P=0.022N*   |P=0.306N     P=0.330N     P=0.200N     P=0.330N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    0/49 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/41.64      0/45.17      0/39.67      0/47.85     |2/46.09      2/44.80      0/42.98      4/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         4.5%         0.0%         8.8%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |1/36 (3%)    1/33 (3%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |690          718          ---          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.224      P=0.665      P=0.251N     P=0.319      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.227      P=0.684      P=0.253N     P=0.330      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.228      P=0.686      P=0.250N     P=0.331      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.228      P=0.679      P=0.254N     P=0.330      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.241      P=0.685      P=0.248N     P=0.391      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.232      P=0.691N     P=0.253N     P=0.339      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    1/50 (2%)   |3/50 (6%)    3/50 (6%)    2/49 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     2/41.64      2/45.64      3/40.76      1/48.01     |3/46.28      3/45.18      2/43.41      5/45.83      | 
|POLY-3 PERCENT (g) |     4.8%         4.4%         7.4%         2.1%        |6.5%         6.6%         4.6%         10.9%        | 
|TERMINAL (d)       |     2/31 (7%)    1/36 (3%)    0/27 (0%)    0/41 (0%)   |2/36 (6%)    1/33 (3%)    1/35 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     731 (T)      591          488          691         |632          626          610          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.331N     P=0.640N     P=0.459      P=0.400N    |P=0.246      P=0.630      P=0.522N     P=0.329      | 
|POLY 3             |     P=0.351N     P=0.661N     P=0.490      P=0.451N    |P=0.261      P=0.651      P=0.529N     P=0.351      | 
|POLY 1.5           |     P=0.372N     P=0.677N     P=0.489      P=0.471N    |P=0.260      P=0.653      P=0.525N     P=0.350      | 
|POLY 6             |     P=0.325N     P=0.639N     P=0.490      P=0.425N    |P=0.264      P=0.648      P=0.530N     P=0.353      | 
|LOGISTIC REGRESSION|     P=0.431N     P=0.688N     P=0.506      P=0.435N    |P=0.284      P=0.656N     P=0.492N     P=0.431      | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.691N     P=0.500      P=0.500N    |P=0.264      P=0.661N     P=0.510N     P=0.357      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/42.30      4/46.37      2/41.06      1/47.92     |0/45.91      0/44.73      2/44.27      3/44.52      | 
|POLY-3 PERCENT (g) |     2.4%         8.6%         4.9%         2.1%        |0.0%         0.0%         4.5%         6.7%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     508          619          178          715         |---          ---          177          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.340N     P=0.242      P=0.498      P=0.726N    |P=0.027 *    (e)          P=0.227      P=0.113      | 
|POLY 3             |     P=0.345N     P=0.208      P=0.490      P=0.732N    |P=0.026 *    (e)          P=0.229      P=0.113      | 
|POLY 1.5           |     P=0.370N     P=0.193      P=0.492      P=0.744N    |P=0.026 *    (e)          P=0.230      P=0.115      | 
|POLY 6             |     P=0.315N     P=0.229      P=0.485      P=0.716N    |P=0.026 *    (e)          P=0.230      P=0.112      | 
|LOGISTIC REGRESSION|     P=0.500N     P=0.170      P=0.752N     P=0.596     |P=0.031 *    (e)          P=0.550      P=0.119      | 
|COCH-ARM / FISHERS |     P=0.403N     P=0.181      P=0.500      P=0.753N    |P=0.028 *    (e)          P=0.242      P=0.121      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hydrocephalus                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    5/50 (10%)   2/50 (4%)   |5/50 (10%)   10/50 (20%)  5/49 (10%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     3/42.07      3/45.64      5/41.75      2/48.01     |5/46.45      10/45.62     5/43.71      8/45.88      | 
|POLY-3 PERCENT (g) |     7.1%         6.6%         12.0%        4.2%        |10.8%        21.9%        11.4%        17.4%        | 
|TERMINAL (d)       |     2/31 (7%)    2/36 (6%)    0/27 (0%)    1/41 (2%)   |3/36 (8%)    6/33 (18%)   3/35 (9%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     606          591          488          691         |632          626          610          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.349N     P=0.595N     P=0.328      P=0.382N    |P=0.351      P=0.112      P=0.596      P=0.245      | 
|POLY 3             |     P=0.373N     P=0.624N     P=0.351      P=0.440N    |P=0.377      P=0.120      P=0.592      P=0.267      | 
|POLY 1.5           |     P=0.401N     P=0.643N     P=0.348      P=0.465N    |P=0.377      P=0.122      P=0.596      P=0.268      | 
|POLY 6             |     P=0.341N     P=0.601N     P=0.355      P=0.410N    |P=0.379      P=0.117      P=0.592      P=0.268      | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.663      P=0.397      P=0.504N    |P=0.395      P=0.127      P=0.622      P=0.311      | 
|COCH-ARM / FISHERS |     P=0.442N     P=0.661N     P=0.357      P=0.500N    |P=0.390      P=0.131      P=0.617      P=0.277      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |11/50 (22%)  17/50 (34%)  11/49 (22%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |                                                        |11/45.91     17/45.91     11/42.98     7/44.36      | 
|POLY-3 PERCENT (g) |                                                        |24.0%        37.0%        25.6%        15.8%        | 
|TERMINAL (d)       |                                                        |11/36 (31%)  11/33 (33%)  11/35 (31%)  6/33 (18%)   | 
|FIRST INCIDENCE    |                                                        |735 (T)      620          735 (T)      681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.105N     P=0.092      P=0.570      P=0.276N     | 
|POLY 3             |                                                        |P=0.092N     P=0.126      P=0.527      P=0.239N     | 
|POLY 1.5           |                                                        |P=0.089N     P=0.124      P=0.537      P=0.234N     | 
|POLY 6             |                                                        |P=0.096N     P=0.130      P=0.525      P=0.243N     | 
|LOGISTIC REGRESSION|                                                        |P=0.097N     P=0.106      P=0.570      P=0.259N     | 
|COCH-ARM / FISHERS |                                                        |P=0.079N     P=0.133      P=0.574      P=0.218N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |9/50 (18%)   21/50 (42%)  15/49 (31%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |                                                        |9/45.91      21/45.07     15/44.81     12/44.84     | 
|POLY-3 PERCENT (g) |                                                        |19.6%        46.6%        33.5%        26.8%        | 
|TERMINAL (d)       |                                                        |9/36 (25%)   19/33 (58%)  10/35 (29%)  10/33 (30%)  | 
|FIRST INCIDENCE    |                                                        |735 (T)      681          470          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.494      P=0.002 **   P=0.107      P=0.238      | 
|POLY 3             |                                                        |P=0.539      P=0.004 **   P=0.102      P=0.288      | 
|POLY 1.5           |                                                        |P=0.542N     P=0.005 **   P=0.100      P=0.293      | 
|POLY 6             |                                                        |P=0.540      P=0.004 **   P=0.112      P=0.283      | 
|LOGISTIC REGRESSION|                                                        |P=0.519      P=0.003 **   P=0.094      P=0.260      | 
|COCH-ARM / FISHERS |                                                        |P=0.513N     P=0.008 **   P=0.109      P=0.312      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |16/50 (32%)  7/50 (14%)   9/49 (18%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |                                                        |16/45.91     7/44.80      9/44.09      11/44.91     | 
|POLY-3 PERCENT (g) |                                                        |34.9%        15.6%        20.4%        24.5%        | 
|TERMINAL (d)       |                                                        |16/36 (44%)  6/33 (18%)   7/35 (20%)   8/33 (24%)   | 
|FIRST INCIDENCE    |                                                        |735 (T)      718          177          590          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.325N     P=0.041N*    P=0.089N     P=0.253N     | 
|POLY 3             |                                                        |P=0.277N     P=0.028N*    P=0.095N     P=0.196N     | 
|POLY 1.5           |                                                        |P=0.278N     P=0.029N*    P=0.095N     P=0.196N     | 
|POLY 6             |                                                        |P=0.271N     P=0.028N*    P=0.091N     P=0.193N     | 
|LOGISTIC REGRESSION|                                                        |P=0.303N     P=0.039N*    P=0.105N     P=0.229N     | 
|COCH-ARM / FISHERS |                                                        |P=0.273N     P=0.028N*    P=0.091N     P=0.184N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/49 (12%)   4/50 (8%)    5/50 (10%)  |                                                    | 
|POLY-3 RATE (b)    |     1/41.92      6/44.52      4/39.67      5/47.85     |                                                    | 
|POLY-3 PERCENT (g) |     2.4%         13.5%        10.1%        10.5%       |                                                    | 
|TERMINAL (d)       |     0/31 (0%)    5/36 (14%)   4/27 (15%)   5/41 (12%)  |                                                    | 
|FIRST INCIDENCE    |     655          680          731 (T)      731 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.313      P=0.094      P=0.147      P=0.183     |                                                    | 
|POLY 3             |     P=0.263      P=0.066      P=0.161      P=0.135     |                                                    | 
|POLY 1.5           |     P=0.231      P=0.059      P=0.166      P=0.121     |                                                    | 
|POLY 6             |     P=0.304      P=0.075      P=0.153      P=0.155     |                                                    | 
|LOGISTIC REGRESSION|     P=0.293      P=0.070      P=0.155      P=0.146     |                                                    | 
|COCH-ARM / FISHERS |     P=0.193      P=0.053      P=0.181      P=0.102     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/41.64      0/44.33      2/39.67      0/47.85     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         5.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    2/27 (7%)    0/41 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          731 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.637      (e)          P=0.208      (e)         |                                                    | 
|POLY 3             |     P=0.661      (e)          P=0.226      (e)         |                                                    | 
|POLY 1.5           |     P=0.637      (e)          P=0.229      (e)         |                                                    | 
|POLY 6             |     P=0.687      (e)          P=0.222      (e)         |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.208      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.596      (e)          P=0.247      (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/1 (100%)   1/2 (50%)    1/1 (100%)   0/0 (0%)    |0/0 (0%)     3/3 (100%)   0/1 (0%)     2/2 (100%)   | 
|POLY-3 RATE (b)    |     1/1.00       1/1.98       1/1.00       0/0.00      |0/0.00       3/3.00       0/0.70       2/2.00       | 
|POLY-3 PERCENT (g) |     100.0%       50.6%        100.0%       0.0%        |0.0%         100.0%       0.0%         100.0%       | 
|TERMINAL (d)       |     1/1 (100%)   1/1 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     2/2 (100%)   0/0 (0%)     2/2 (100%)   | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      621          ---         |---          697          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.716      P=1.000      (e)          (e)         |P=0.578N     (e)          (e)          (e)          | 
|POLY 3             |     (e)          P=0.619N     (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          P=0.616N     (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          P=0.625N     (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.973N     P=1.000      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.949      P=0.667N     (e)          (e)         |P=0.752      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/1 (100%)   0/2 (0%)     1/1 (100%)   0/0 (0%)    |0/0 (0%)     3/3 (100%)   0/1 (0%)     2/2 (100%)   | 
|POLY-3 RATE (b)    |     1/1.00       0/1.98       1/1.00       0/0.00      |0/0.00       3/3.00       0/0.70       2/2.00       | 
|POLY-3 PERCENT (g) |     100.0%       0.0%         100.0%       0.0%        |0.0%         100.0%       0.0%         100.0%       | 
|TERMINAL (d)       |     1/1 (100%)   0/1 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     2/2 (100%)   0/0 (0%)     2/2 (100%)   | 
|FIRST INCIDENCE    |     731 (T)      ---          621          ---         |---          697          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.651N     P=0.500N     (e)          (e)         |P=0.578N     (e)          (e)          (e)          | 
|POLY 3             |     (e)          P<0.001N**   (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          P<0.001N**   (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          P<0.001N**   (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.824N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.921      P=0.333N     (e)          (e)         |P=0.752      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     46/50 (92%)  46/50 (92%)  45/50 (90%)  50/50 (100%)|45/50 (90%)  45/50 (90%)  43/49 (88%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     46/50.00     46/49.42     45/47.34     50/50.00    |45/48.97     45/48.49     43/46.55     44/49.03     | 
|POLY-3 PERCENT (g) |     92.0%        93.1%        95.1%        100.0%      |91.9%        92.8%        92.4%        89.7%        | 
|TERMINAL (d)       |     27/31 (87%)  35/36 (97%)  26/27 (96%)  41/41 (100%)|35/36 (97%)  33/33 (100%) 33/35 (94%)  29/33 (88%)  | 
|FIRST INCIDENCE    |     429          170          178          499         |523          561          459          172          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.150N     P=0.177N     P=0.350      P=0.098N    |P=0.422      P=0.310      P=0.552N     P=0.393      | 
|POLY 3             |     P=0.030 *    P=0.571      P=0.418      P=0.061     |P=0.380N     P=0.590      P=0.625      P=0.492N     | 
|POLY 1.5           |     P=0.038 *    P=0.606      P=0.532      P=0.061     |P=0.386N     P=0.558      P=0.644      P=0.502N     | 
|POLY 6             |     P=0.025 *    P=0.507      P=0.299      P=0.061     |P=0.342N     P=0.650      P=0.646      P=0.454N     | 
|LOGISTIC REGRESSION|     P=0.084      P=0.593      P=0.597N     (e)         |P=0.504N     P=0.532      P=0.562      P=0.545N     | 
|COCH-ARM / FISHERS |     P=0.066      P=0.643N     P=0.500N     P=0.059     |P=0.408N     P=0.630N     P=0.486N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.64      0/45.17      2/40.25      1/47.94     |0/45.91      1/44.73      1/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         5.0%         2.1%        |0.0%         2.2%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    1/33 (3%)    1/35 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          624          709         |---          735 (T)      735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.303      (e)          P=0.230      P=0.559     |P=0.608N     P=0.483      P=0.494      (e)          | 
|POLY 3             |     P=0.293      (e)          P=0.229      P=0.528     |P=0.606N     P=0.495      P=0.487      (e)          | 
|POLY 1.5           |     P=0.274      (e)          P=0.230      P=0.516     |P=0.603N     P=0.496      P=0.489      (e)          | 
|POLY 6             |     P=0.316      (e)          P=0.228      P=0.542     |P=0.610N     P=0.493      P=0.486      (e)          | 
|LOGISTIC REGRESSION|     P=0.229      (e)          P=0.243      P=0.520     |(e)          P=0.483      P=0.494      (e)          | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |P=0.595N     P=0.500      P=0.495      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/42.74      0/45.17      1/40.04      0/47.85     |0/45.91      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     7.0%         0.0%         2.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     429          ---          624          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.075N     P=0.106N     P=0.335N     P=0.092N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.083N     P=0.109N     P=0.328N     P=0.100N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.084N     P=0.114N     P=0.323N     P=0.108N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.083N     P=0.102N     P=0.336N     P=0.091N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.090N     P=0.111N     P=0.246N     P=0.278N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.086N     P=0.121N     P=0.309N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    1/50 (2%)    1/50 (2%)   |5/50 (10%)   0/50 (0%)    4/49 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/42.07      3/45.17      1/39.67      1/47.85     |5/45.91      0/44.73      4/43.48      1/44.16      | 
|POLY-3 PERCENT (g) |     9.5%         6.6%         2.5%         2.1%        |10.9%        0.0%         9.2%         2.3%         | 
|TERMINAL (d)       |     3/31 (10%)   3/36 (8%)    1/27 (4%)    1/41 (2%)   |5/36 (14%)   0/33 (0%)    2/35 (6%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     606          731 (T)      731 (T)      731 (T)     |735 (T)      ---          652          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.064N     P=0.422N     P=0.217N     P=0.112N    |P=0.183N     P=0.040N*    P=0.525N     P=0.122N     | 
|POLY 3             |     P=0.080N     P=0.461N     P=0.196N     P=0.142N    |P=0.167N     P=0.033N*    P=0.534N     P=0.110N     | 
|POLY 1.5           |     P=0.085N     P=0.481N     P=0.192N     P=0.157N    |P=0.165N     P=0.032N*    P=0.531N     P=0.108N     | 
|POLY 6             |     P=0.073N     P=0.437N     P=0.203N     P=0.126N    |P=0.167N     P=0.033N*    P=0.529N     P=0.113N     | 
|LOGISTIC REGRESSION|     P=0.069N     P=0.444N     P=0.196N     P=0.150N    |P=0.176N     (e)          P=0.540N     P=0.122N     | 
|COCH-ARM / FISHERS |     P=0.092N     P=0.500N     P=0.181N     P=0.181N    |P=0.163N     P=0.028N*    P=0.513N     P=0.102N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   8/50 (16%)   4/50 (8%)   |4/50 (8%)    1/50 (2%)    3/49 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/42.07      5/45.25      8/39.87      4/48.01     |4/46.07      1/44.73      3/43.34      1/44.64      | 
|POLY-3 PERCENT (g) |     9.5%         11.1%        20.1%        8.3%        |8.7%         2.2%         6.9%         2.2%         | 
|TERMINAL (d)       |     3/31 (10%)   4/36 (11%)   7/27 (26%)   3/41 (7%)   |3/36 (8%)    1/33 (3%)    2/35 (6%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     606          710          676          691         |695          735 (T)      632          590          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.413N     P=0.591      P=0.124      P=0.489N    |P=0.215N     P=0.204N     P=0.520N     P=0.205N     | 
|POLY 3             |     P=0.479N     P=0.546      P=0.148      P=0.569N    |P=0.200N     P=0.188N     P=0.533N     P=0.188N     | 
|POLY 1.5           |     P=0.519N     P=0.523      P=0.156      P=0.600N    |P=0.199N     P=0.186N     P=0.529N     P=0.186N     | 
|POLY 6             |     P=0.429N     P=0.574      P=0.137      P=0.530N    |P=0.200N     P=0.191N     P=0.533N     P=0.191N     | 
|LOGISTIC REGRESSION|     P=0.451N     P=0.570      P=0.139      P=0.585N    |P=0.197N     P=0.193N     P=0.530N     P=0.173N     | 
|COCH-ARM / FISHERS |     P=0.547      P=0.500      P=0.178      P=0.643N    |P=0.195N     P=0.181N     P=0.511N     P=0.181N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.64      1/45.63      2/39.81      0/47.85     |0/45.91      1/44.73      0/42.98      1/44.70      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         5.0%         0.0%        |0.0%         2.2%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    1/27 (4%)    0/41 (0%)   |0/36 (0%)    1/33 (3%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          593          695          ---         |---          735 (T)      ---          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.562N     P=0.522      P=0.211      (e)         |P=0.399      P=0.483      (e)          P=0.500      | 
|POLY 3             |     P=0.564N     P=0.518      P=0.227      (e)         |P=0.397      P=0.495      (e)          P=0.495      | 
|POLY 1.5           |     P=0.585N     P=0.509      P=0.229      (e)         |P=0.399      P=0.496      (e)          P=0.496      | 
|POLY 6             |     P=0.537N     P=0.530      P=0.223      (e)         |P=0.395      P=0.493      (e)          P=0.493      | 
|LOGISTIC REGRESSION|     P=0.630N     P=0.513      P=0.221      (e)         |P=0.420      P=0.483      (e)          P=0.607      | 
|COCH-ARM / FISHERS |     P=0.616N     P=0.500      P=0.247      (e)         |P=0.405      P=0.500      (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/50 (62%)  30/50 (60%)  32/50 (64%)  38/50 (76%) |38/50 (76%)  28/50 (56%)  33/49 (67%)  30/50 (60%)  | 
|POLY-3 RATE (b)    |     31/46.41     30/47.47     32/43.08     38/48.92    |38/48.65     28/47.76     33/47.91     30/46.96     | 
|POLY-3 PERCENT (g) |     66.8%        63.2%        74.3%        77.7%       |78.1%        58.6%        68.9%        63.9%        | 
|TERMINAL (d)       |     20/31 (65%)  24/36 (67%)  23/27 (85%)  32/41 (78%) |29/36 (81%)  16/33 (49%)  22/35 (63%)  20/33 (61%)  | 
|FIRST INCIDENCE    |     499          404          560          633         |523          597          177          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.511      P=0.221N     P=0.271      P=0.429N    |P=0.304N     P=0.137N     P=0.328N     P=0.225N     | 
|POLY 3             |     P=0.073      P=0.440N     P=0.285      P=0.163     |P=0.179N     P=0.029N*    P=0.209N     P=0.089N     | 
|POLY 1.5           |     P=0.064      P=0.474N     P=0.347      P=0.132     |P=0.169N     P=0.032N*    P=0.223N     P=0.085N     | 
|POLY 6             |     P=0.088      P=0.408N     P=0.210      P=0.206     |P=0.187N     P=0.024N*    P=0.180N     P=0.090N     | 
|LOGISTIC REGRESSION|     P=0.131      P=0.456N     P=0.397      P=0.196     |P=0.153N     P=0.033N*    P=0.210N     P=0.086N     | 
|COCH-ARM / FISHERS |     P=0.057      P=0.500N     P=0.500      P=0.097     |P=0.145N     P=0.028N*    P=0.232N     P=0.066N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/50 (94%)  49/50 (98%)  44/50 (88%)  45/50 (90%) |43/50 (86%)  41/50 (82%)  38/49 (78%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     47/48.89     49/49.92     44/47.17     45/48.91    |43/49.75     41/46.75     38/47.48     40/47.17     | 
|POLY-3 PERCENT (g) |     96.1%        98.2%        93.3%        92.0%       |86.4%        87.7%        80.0%        84.8%        | 
|TERMINAL (d)       |     31/31 (100%) 36/36 (100%) 27/27 (100%) 41/41 (100%)|31/36 (86%)  32/33 (97%)  28/35 (80%)  31/33 (94%)  | 
|FIRST INCIDENCE    |     429          170          178          499         |523          618          177          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005N**   P=0.240N     P=0.451      P=0.002N**  |P=0.498N     P=0.486      P=0.338N     P=0.558      | 
|POLY 3             |     P=0.118N     P=0.501      P=0.418N     P=0.309N    |P=0.385N     P=0.548      P=0.280N     P=0.526N     | 
|POLY 1.5           |     P=0.131N     P=0.396      P=0.372N     P=0.330N    |P=0.336N     P=0.596N     P=0.248N     P=0.445N     | 
|POLY 6             |     P=0.106N     P=0.712      P=0.483N     P=0.283N    |P=0.459N     P=0.408      P=0.316N     P=0.611      | 
|LOGISTIC REGRESSION|     P=0.075N     P=0.314      P=0.366N     P=0.146N    |P=0.321N     P=0.471N     P=0.196N     P=0.380N     | 
|COCH-ARM / FISHERS |     P=0.148N     P=0.309      P=0.243N     P=0.357N    |P=0.258N     P=0.393N     P=0.204N     P=0.298N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/50 (52%)  32/50 (64%)  23/50 (46%)  33/50 (66%) |44/50 (88%)  42/50 (84%)  43/49 (88%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     26/43.54     32/45.17     23/41.09     33/48.09    |44/48.51     42/46.49     43/46.53     44/48.22     | 
|POLY-3 PERCENT (g) |     59.7%        70.9%        56.0%        68.6%       |90.7%        90.4%        92.4%        91.2%        | 
|TERMINAL (d)       |     21/31 (68%)  32/36 (89%)  20/27 (74%)  31/41 (76%) |34/36 (94%)  33/33 (100%) 34/35 (97%)  32/33 (97%)  | 
|FIRST INCIDENCE    |     577          731 (T)      488          691         |597          652          470          172          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.370N     P=0.422      P=0.586      P=0.508N    |P=0.269      P=0.472      P=0.533      P=0.306      | 
|POLY 3             |     P=0.322      P=0.177      P=0.447N     P=0.244     |P=0.508      P=0.627N     P=0.530      P=0.612      | 
|POLY 1.5           |     P=0.251      P=0.157      P=0.418N     P=0.178     |P=0.506      P=0.544N     P=0.543      P=0.622      | 
|POLY 6             |     P=0.431      P=0.199      P=0.507N     P=0.344     |P=0.501      P=0.565      P=0.524      P=0.575      | 
|LOGISTIC REGRESSION|     P=0.456N     P=0.465      P=0.445N     P=0.527     |P=0.310      P=0.483N     P=0.388      P=0.509      | 
|COCH-ARM / FISHERS |     P=0.180      P=0.156      P=0.345N     P=0.111     |P=0.473      P=0.387N     P=0.606N     P=0.620N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |2/50 (4%)    2/50 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.64      0/45.17      0/39.67      3/47.85     |2/45.91      2/45.12      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         6.3%        |4.4%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/36 (0%)    0/27 (0%)    3/41 (7%)   |2/36 (6%)    1/33 (3%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     731 (T)      ---          ---          731 (T)     |735 (T)      626          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.128      P=0.470N     P=0.528N     P=0.409     |P=0.094N     P=0.668      P=0.244N     P=0.258N     | 
|POLY 3             |     P=0.089      P=0.484N     P=0.510N     P=0.357     |P=0.090N     P=0.688      P=0.252N     P=0.246N     | 
|POLY 1.5           |     P=0.087      P=0.492N     P=0.508N     P=0.335     |P=0.089N     P=0.688      P=0.250N     P=0.244N     | 
|POLY 6             |     P=0.091      P=0.474N     P=0.513N     P=0.385     |P=0.091N     P=0.686      P=0.252N     P=0.249N     | 
|LOGISTIC REGRESSION|     P=0.128      (e)          (e)          P=0.409     |P=0.089N     P=0.693      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.086      P=0.500N     P=0.500N     P=0.309     |P=0.087N     P=0.691N     P=0.253N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.07      0/45.17      2/39.67      0/47.85     |1/45.91      0/44.73      0/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         5.0%         0.0%        |2.2%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    2/27 (7%)    0/41 (0%)   |1/36 (3%)    0/33 (0%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     606          ---          731 (T)      ---         |735 (T)      ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.412N     P=0.477N     P=0.465      P=0.464N    |P=0.582      P=0.517N     P=0.506N     P=0.742      | 
|POLY 3             |     P=0.432N     P=0.486N     P=0.479      P=0.474N    |P=0.590      P=0.505N     P=0.513N     P=0.752      | 
|POLY 1.5           |     P=0.442N     P=0.493N     P=0.485      P=0.485N    |P=0.591      P=0.504N     P=0.511N     P=0.754      | 
|POLY 6             |     P=0.419N     P=0.477N     P=0.471      P=0.462N    |P=0.590      P=0.507N     P=0.514N     P=0.749      | 
|LOGISTIC REGRESSION|     P=0.459N     P=0.493N     P=0.488      P=0.675N    |P=0.582      (e)          (e)          P=0.742      | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.500N     P=0.500      P=0.500N    |P=0.594      P=0.500N     P=0.505N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |2/50 (4%)    3/50 (6%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.64      0/45.17      2/40.17      0/47.85     |2/45.91      3/45.33      0/42.98      1/44.51      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         5.0%         0.0%        |4.4%         6.6%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/31 (3%)    0/36 (0%)    1/27 (4%)    0/41 (0%)   |2/36 (6%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     731 (T)      ---          577          ---         |735 (T)      652          ---          634          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.418N     P=0.470N     P=0.463      P=0.444N    |P=0.259N     P=0.482      P=0.244N     P=0.523N     | 
|POLY 3             |     P=0.431N     P=0.484N     P=0.487      P=0.472N    |P=0.251N     P=0.494      P=0.252N     P=0.511N     | 
|POLY 1.5           |     P=0.442N     P=0.492N     P=0.489      P=0.484N    |P=0.250N     P=0.493      P=0.250N     P=0.508N     | 
|POLY 6             |     P=0.418N     P=0.474N     P=0.484      P=0.458N    |P=0.253N     P=0.495      P=0.252N     P=0.513N     | 
|LOGISTIC REGRESSION|     P=0.468N     (e)          P=0.493      (e)         |P=0.238N     P=0.501      (e)          P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.500N     P=0.500      P=0.500N    |P=0.243N     P=0.500      P=0.253N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    5/50 (10%)   4/50 (8%)   |5/50 (10%)   12/50 (24%)  9/49 (18%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/41.64      1/45.17      5/39.87      4/47.85     |5/46.41      12/46.03     9/44.37      7/45.19      | 
|POLY-3 PERCENT (g) |     4.8%         2.2%         12.5%        8.4%        |10.8%        26.1%        20.3%        15.5%        | 
|TERMINAL (d)       |     2/31 (7%)    1/36 (3%)    4/27 (15%)   4/41 (10%)  |3/36 (8%)    8/33 (24%)   6/35 (17%)   5/33 (15%)   | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      676          731 (T)     |632          561          459          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.253      P=0.448N     P=0.169      P=0.472     |P=0.487      P=0.046 *    P=0.182      P=0.336      | 
|POLY 3             |     P=0.203      P=0.472N     P=0.197      P=0.403     |P=0.506      P=0.049 *    P=0.167      P=0.360      | 
|POLY 1.5           |     P=0.184      P=0.486N     P=0.201      P=0.375     |P=0.513      P=0.050      P=0.169      P=0.365      | 
|POLY 6             |     P=0.228      P=0.454N     P=0.191      P=0.439     |P=0.497      P=0.048 *    P=0.169      P=0.354      | 
|LOGISTIC REGRESSION|     P=0.245      P=0.448N     P=0.175      P=0.472     |P=0.542      P=0.054      P=0.194      P=0.390      | 
|COCH-ARM / FISHERS |     P=0.157      P=0.500N     P=0.218      P=0.339     |P=0.537      P=0.054      P=0.183      P=0.380      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     37/50 (74%)  38/50 (76%)  31/50 (62%)  39/50 (78%) |41/50 (82%)  42/50 (84%)  42/49 (86%)  43/50 (86%)  | 
|POLY-3 RATE (b)    |     37/45.01     38/47.71     31/43.52     39/48.31    |41/47.63     42/46.97     42/46.92     43/47.24     | 
|POLY-3 PERCENT (g) |     82.2%        79.7%        71.2%        80.7%       |86.1%        89.4%        89.5%        91.0%        | 
|TERMINAL (d)       |     30/31 (97%)  33/36 (92%)  22/27 (82%)  36/41 (88%) |34/36 (94%)  32/33 (97%)  33/35 (94%)  32/33 (97%)  | 
|FIRST INCIDENCE    |     499          170          178          675         |620          618          177          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.057N     P=0.203N     P=0.407N     P=0.034N*   |P=0.187      P=0.235      P=0.373      P=0.168      | 
|POLY 3             |     P=0.477N     P=0.479N     P=0.139N     P=0.536N    |P=0.272      P=0.421      P=0.416      P=0.317      | 
|POLY 1.5           |     P=0.543      P=0.564N     P=0.146N     P=0.564     |P=0.279      P=0.424      P=0.407      P=0.321      | 
|POLY 6             |     P=0.360N     P=0.384N     P=0.143N     P=0.386N    |P=0.283      P=0.410      P=0.449      P=0.327      | 
|LOGISTIC REGRESSION|     P=0.373N     P=0.550N     P=0.197N     P=0.174N    |P=0.189      P=0.372      P=0.255      P=0.193      | 
|COCH-ARM / FISHERS |     P=0.447      P=0.500      P=0.142N     P=0.408     |P=0.336      P=0.500      P=0.410      P=0.393      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  32/50 (64%)  20/50 (40%)  32/50 (64%) |25/50 (50%)  24/50 (48%)  27/49 (55%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     29/42.61     32/45.19     20/39.67     32/47.85    |25/46.88     24/45.89     27/42.98     20/45.15     | 
|POLY-3 PERCENT (g) |     68.1%        70.8%        50.4%        66.9%       |53.3%        52.3%        62.8%        44.3%        | 
|TERMINAL (d)       |     26/31 (84%)  31/36 (86%)  20/27 (74%)  32/41 (78%) |21/36 (58%)  21/33 (64%)  27/35 (77%)  17/33 (52%)  | 
|FIRST INCIDENCE    |     577          725          731 (T)      731 (T)     |620          561          735 (T)      536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.070N     P=0.443N     P=0.093N     P=0.126N    |P=0.277N     P=0.506      P=0.339      P=0.332N     | 
|POLY 3             |     P=0.404N     P=0.480      P=0.064N     P=0.543N    |P=0.244N     P=0.544N     P=0.237      P=0.252N     | 
|POLY 1.5           |     P=0.506N     P=0.398      P=0.064N     P=0.508     |P=0.228N     P=0.536N     P=0.281      P=0.241N     | 
|POLY 6             |     P=0.271N     P=0.597      P=0.070N     P=0.376N    |P=0.264N     P=0.567N     P=0.197      P=0.272N     | 
|LOGISTIC REGRESSION|     P=0.074N     P=0.329N     P=0.062N     P=0.130N    |P=0.263N     P=0.565N     P=0.274      P=0.273N     | 
|COCH-ARM / FISHERS |     P=0.452      P=0.341      P=0.055N     P=0.341     |P=0.198N     P=0.500N     P=0.380      P=0.211N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    3/50 (6%)    5/50 (10%)  |3/50 (6%)    4/50 (8%)    1/49 (2%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     5/43.41      2/45.59      3/40.54      5/48.49     |3/46.16      4/45.93      1/43.57      6/45.13      | 
|POLY-3 PERCENT (g) |     11.5%        4.4%         7.4%         10.3%       |6.5%         8.7%         2.3%         13.3%        | 
|TERMINAL (d)       |     2/31 (7%)    0/36 (0%)    1/27 (4%)    2/41 (5%)   |1/36 (3%)    1/33 (3%)    0/35 (0%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     429          672          593          633         |670          561          543          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.562      P=0.172N     P=0.399N     P=0.478N    |P=0.186      P=0.474      P=0.330N     P=0.218      | 
|POLY 3             |     P=0.488      P=0.196N     P=0.394N     P=0.559N    |P=0.189      P=0.497      P=0.326N     P=0.231      | 
|POLY 1.5           |     P=0.471      P=0.208N     P=0.385N     P=0.590N    |P=0.191      P=0.495      P=0.324N     P=0.233      | 
|POLY 6             |     P=0.512      P=0.181N     P=0.405N     P=0.518N    |P=0.187      P=0.498      P=0.326N     P=0.228      | 
|LOGISTIC REGRESSION|     P=0.385      P=0.225N     P=0.296N     P=0.350     |P=0.216      P=0.540      P=0.269N     P=0.251      | 
|COCH-ARM / FISHERS |     P=0.446      P=0.218N     P=0.357N     P=0.630N    |P=0.199      P=0.500      P=0.316N     P=0.243      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     46/50 (92%)  45/50 (90%)  43/50 (86%)  43/50 (86%) |25/50 (50%)  28/50 (56%)  21/49 (43%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     46/48.14     45/47.58     43/45.90     43/48.57    |25/47.53     28/46.32     21/44.14     18/45.43     | 
|POLY-3 PERCENT (g) |     95.6%        94.6%        93.7%        88.5%       |52.6%        60.5%        47.6%        39.6%        | 
|TERMINAL (d)       |     31/31 (100%) 36/36 (100%) 27/27 (100%) 39/41 (95%) |19/36 (53%)  21/33 (64%)  17/35 (49%)  13/33 (39%)  | 
|FIRST INCIDENCE    |     429          591          488          633         |597          597          610          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004N**   P=0.090N     P=0.450      P<0.001N**  |P=0.091N     P=0.231      P=0.344N     P=0.213N     | 
|POLY 3             |     P=0.075N     P=0.620N     P=0.528N     P=0.156N    |P=0.057N     P=0.285      P=0.392N     P=0.145N     | 
|POLY 1.5           |     P=0.113N     P=0.620N     P=0.472N     P=0.201N    |P=0.052N     P=0.298      P=0.370N     P=0.135N     | 
|POLY 6             |     P=0.040N*    P=0.583N     P=0.577N     P=0.107N    |P=0.063N     P=0.261      P=0.406N     P=0.158N     | 
|LOGISTIC REGRESSION|     P=0.016N*    P=0.334N     P=0.418N     P=0.036N*   |P=0.058N     P=0.295      P=0.379N     P=0.140N     | 
|COCH-ARM / FISHERS |     P=0.194N     P=0.500N     P=0.262N     P=0.262N    |P=0.043N*    P=0.344      P=0.305N     P=0.113N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    4/50 (8%)    5/50 (10%)  |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     7/41.73      3/45.17      4/39.67      5/47.85     |1/46.31      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     16.8%        6.6%         10.1%        10.5%       |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     6/31 (19%)   3/36 (8%)    4/27 (15%)   5/41 (12%)  |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     707          731 (T)      731 (T)      731 (T)     |620          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.277N     P=0.104N     P=0.344N     P=0.203N    |P=0.317N     P=0.504N     P=0.522N     P=0.513N     | 
|POLY 3             |     P=0.371N     P=0.126N     P=0.288N     P=0.287N    |P=0.302N     P=0.507N     P=0.515N     P=0.510N     | 
|POLY 1.5           |     P=0.391N     P=0.141N     P=0.283N     P=0.325N    |P=0.304N     P=0.505N     P=0.512N     P=0.507N     | 
|POLY 6             |     P=0.347N     P=0.108N     P=0.299N     P=0.244N    |P=0.299N     P=0.510N     P=0.516N     P=0.513N     | 
|LOGISTIC REGRESSION|     P=0.279N     P=0.095N     P=0.332N     P=0.199N    |P=0.288N     P=0.451N     P=0.440N     P=0.441N     | 
|COCH-ARM / FISHERS |     P=0.419N     P=0.159N     P=0.262N     P=0.380N    |P=0.306N     P=0.500N     P=0.505N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.09      1/45.33      2/39.67      1/47.85     |1/45.91      2/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     2.4%         2.2%         5.0%         2.1%        |2.2%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    2/27 (7%)    1/41 (2%)   |1/36 (3%)    2/33 (6%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     598          690          731 (T)      731 (T)     |735 (T)      735 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.574N     P=0.732N     P=0.462      P=0.712N    |P=0.198N     P=0.470      P=0.506N     P=0.517N     | 
|POLY 3             |     P=0.613N     P=0.744N     P=0.479      P=0.731N    |P=0.196N     P=0.491      P=0.513N     P=0.508N     | 
|POLY 1.5           |     P=0.621      P=0.752N     P=0.485      P=0.744N    |P=0.194N     P=0.493      P=0.511N     P=0.506N     | 
|POLY 6             |     P=0.596N     P=0.733N     P=0.470      P=0.716N    |P=0.198N     P=0.487      P=0.514N     P=0.510N     | 
|LOGISTIC REGRESSION|     P=0.602      P=0.759      P=0.489      P=0.708     |P=0.198N     P=0.470      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.591      P=0.753N     P=0.500      P=0.753N    |P=0.189N     P=0.500      P=0.505N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     37/50 (74%)  36/50 (72%)  32/50 (64%)  34/50 (68%) |32/50 (64%)  25/50 (50%)  14/49 (29%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     37/45.78     36/46.57     32/45.57     34/48.42    |32/47.61     25/47.59     14/44.67     18/46.08     | 
|POLY-3 PERCENT (g) |     80.8%        77.3%        70.2%        70.2%       |67.2%        52.5%        31.3%        39.1%        | 
|TERMINAL (d)       |     26/31 (84%)  31/36 (86%)  19/27 (70%)  31/41 (76%) |26/36 (72%)  16/33 (49%)  9/35 (26%)   10/33 (30%)  | 
|FIRST INCIDENCE    |     505          593          178          672         |523          561          459          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.019N*    P=0.138N     P=0.478N     P=0.012N*   |P=0.011N*    P=0.244N     P<0.001N**   P=0.025N*    | 
|POLY 3             |     P=0.115N     P=0.433N     P=0.159N     P=0.160N    |P=0.002N**   P=0.100N     P<0.001N**   P=0.004N**   | 
|POLY 1.5           |     P=0.162N     P=0.482N     P=0.180N     P=0.221N    |P=0.002N**   P=0.113N     P<0.001N**   P=0.004N**   | 
|POLY 6             |     P=0.075N     P=0.380N     P=0.151N     P=0.106N    |P=0.002N**   P=0.086N     P<0.001N**   P=0.004N**   | 
|LOGISTIC REGRESSION|     P=0.115N     P=0.245N     P=0.250N     P=0.064N    |P=0.003N**   P=0.128N     P<0.001N**   P=0.006N**   | 
|COCH-ARM / FISHERS |     P=0.258N     P=0.500N     P=0.194N     P=0.330N    |P=0.002N**   P=0.113N     P<0.001N**   P=0.004N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.64      0/45.17      0/39.67      2/47.85     |0/45.91      0/44.73      0/42.98      1/44.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.2%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    2/41 (5%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          731 (T)     |---          ---          ---          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.068      (e)          (e)          P=0.302     |P=0.194      (e)          (e)          P=0.483      | 
|POLY 3             |     P=0.050      (e)          (e)          P=0.270     |P=0.195      (e)          (e)          P=0.492      | 
|POLY 1.5           |     P=0.048 *    (e)          (e)          P=0.256     |P=0.197      (e)          (e)          P=0.494      | 
|POLY 6             |     P=0.052      (e)          (e)          P=0.287     |P=0.194      (e)          (e)          P=0.490      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.302     |P=0.194      (e)          (e)          P=0.489      | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.199      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     32/50 (64%)  31/50 (62%)  27/50 (54%)  36/50 (72%) |36/50 (72%)  40/50 (80%)  37/49 (76%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     32/44.20     31/46.00     27/43.37     36/48.82    |36/46.90     40/46.90     37/45.83     33/46.22     | 
|POLY-3 PERCENT (g) |     72.4%        67.4%        62.3%        73.7%       |76.8%        85.3%        80.7%        71.4%        | 
|TERMINAL (d)       |     27/31 (87%)  30/36 (83%)  20/27 (74%)  33/41 (81%) |32/36 (89%)  31/33 (94%)  31/35 (89%)  26/33 (79%)  | 
|FIRST INCIDENCE    |     499          404          123          499         |620          620          177          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.259N     P=0.124N     P=0.453N     P=0.177N    |P=0.351N     P=0.083      P=0.393      P=0.574N     | 
|POLY 3             |     P=0.422      P=0.380N     P=0.199N     P=0.537     |P=0.182N     P=0.199      P=0.410      P=0.355N     | 
|POLY 1.5           |     P=0.333      P=0.444N     P=0.199N     P=0.410     |P=0.191N     P=0.195      P=0.417      P=0.362N     | 
|POLY 6             |     P=0.550N     P=0.309N     P=0.213N     P=0.504N    |P=0.166N     P=0.209      P=0.414      P=0.340N     | 
|LOGISTIC REGRESSION|     P=0.426      P=0.219N     P=0.267N     P=0.477N    |P=0.266N     P=0.124      P=0.288      P=0.473N     | 
|COCH-ARM / FISHERS |     P=0.229      P=0.500N     P=0.208N     P=0.260     |P=0.184N     P=0.241      P=0.433      P=0.333N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     46/50 (92%)  47/50 (94%)  48/50 (96%)  49/50 (98%) |45/50 (90%)  47/50 (94%)  45/49 (92%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     46/48.78     47/49.72     48/49.93     49/50.00    |45/49.83     47/48.70     45/48.14     44/49.22     | 
|POLY-3 PERCENT (g) |     94.3%        94.5%        96.1%        98.0%       |90.3%        96.5%        93.5%        89.4%        | 
|TERMINAL (d)       |     30/31 (97%)  35/36 (97%)  26/27 (96%)  40/41 (98%) |32/36 (89%)  32/33 (97%)  33/35 (94%)  29/33 (88%)  | 
|FIRST INCIDENCE    |     429          170          123          499         |523          561          177          172          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.106N     P=0.201N     P=0.187      P=0.055N    |P=0.460      P=0.225      P=0.442      P=0.407      | 
|POLY 3             |     P=0.206      P=0.664      P=0.519      P=0.317     |P=0.366N     P=0.197      P=0.418      P=0.574N     | 
|POLY 1.5           |     P=0.158      P=0.588      P=0.429      P=0.242     |P=0.336N     P=0.214      P=0.450      P=0.542N     | 
|POLY 6             |     P=0.302      P=0.635N     P=0.660      P=0.468     |P=0.406N     P=0.180      P=0.397      P=0.612N     | 
|LOGISTIC REGRESSION|     P=0.113      P=0.514      P=0.337      P=0.277     |P=0.373N     P=0.263      P=0.504      P=0.487N     | 
|COCH-ARM / FISHERS |     P=0.114      P=0.500      P=0.339      P=0.181     |P=0.337N     P=0.357      P=0.513      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  32/50 (64%)  23/50 (46%)  35/50 (70%) |47/50 (94%)  44/50 (88%)  44/49 (90%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     35/44.21     32/46.43     23/41.35     35/49.12    |47/49.18     44/47.80     44/46.70     44/46.78     | 
|POLY-3 PERCENT (g) |     79.2%        68.9%        55.6%        71.3%       |95.6%        92.1%        94.2%        94.1%        | 
|TERMINAL (d)       |     29/31 (94%)  28/36 (78%)  18/27 (67%)  30/41 (73%) |36/36 (100%) 31/33 (94%)  34/35 (97%)  33/33 (100%) | 
|FIRST INCIDENCE    |     505          591          488          499         |526          597          459          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.064N     P=0.056N     P=0.047N*    P=0.038N*   |P=0.511      P=0.548      P=0.474N     P=0.529      | 
|POLY 3             |     P=0.284N     P=0.176N     P=0.010N*    P=0.250N    |P=0.535N     P=0.374N     P=0.574N     P=0.560N     | 
|POLY 1.5           |     P=0.379N     P=0.257N     P=0.012N*    P=0.390N    |P=0.415N     P=0.350N     P=0.505N     P=0.426N     | 
|POLY 6             |     P=0.174N     P=0.091N     P=0.008N**   P=0.114N    |P=0.493      P=0.417N     P=0.663N     P=0.737      | 
|LOGISTIC REGRESSION|     P=0.150N     P=0.082N     P=0.013N*    P=0.152N    |P=0.423N     P=0.295N     P=0.610N     P=0.415N     | 
|COCH-ARM / FISHERS |     P=0.510N     P=0.335N     P=0.013N*    P=0.586N    |P=0.261N     P=0.243N     P=0.346N     P=0.243N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  10/50 (20%)  9/50 (18%)   11/50 (22%) |12/50 (24%)  15/50 (30%)  13/49 (27%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     10/42.66     10/45.17     9/39.87      11/48.09    |12/45.91     15/44.87     13/42.98     9/44.77      | 
|POLY-3 PERCENT (g) |     23.4%        22.1%        22.6%        22.9%       |26.1%        33.4%        30.3%        20.1%        | 
|TERMINAL (d)       |     8/31 (26%)   10/36 (28%)  8/27 (30%)   9/41 (22%)  |12/36 (33%)  14/33 (42%)  13/35 (37%)  6/33 (18%)   | 
|FIRST INCIDENCE    |     577          731 (T)      676          691         |735 (T)      701          735 (T)      634          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.404N     P=0.458N     P=0.586      P=0.428N    |P=0.240N     P=0.225      P=0.465      P=0.389N     | 
|POLY 3             |     P=0.544N     P=0.543N     P=0.567N     P=0.573N    |P=0.213N     P=0.297      P=0.423      P=0.333N     | 
|POLY 1.5           |     P=0.514      P=0.573N     P=0.548N     P=0.572     |P=0.212N     P=0.303      P=0.435      P=0.330N     | 
|POLY 6             |     P=0.488N     P=0.507N     P=0.595N     P=0.510N    |P=0.210N     P=0.285      P=0.419      P=0.333N     | 
|LOGISTIC REGRESSION|     P=0.449N     P=0.483N     P=0.565N     P=0.555N    |P=0.231N     P=0.227      P=0.465      P=0.364N     | 
|COCH-ARM / FISHERS |     P=0.452      P=0.598N     P=0.500N     P=0.500     |P=0.197N     P=0.326      P=0.477      P=0.312N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  32/50 (64%)  24/50 (48%)  35/50 (70%) |47/50 (94%)  44/50 (88%)  44/49 (90%)  45/50 (90%)  | 
|POLY-3 RATE (b)    |     36/44.90     32/46.43     24/41.35     35/49.12    |47/49.18     44/47.80     44/46.70     45/47.04     | 
|POLY-3 PERCENT (g) |     80.2%        68.9%        58.0%        71.3%       |95.6%        92.1%        94.2%        95.7%        | 
|TERMINAL (d)       |     29/31 (94%)  28/36 (78%)  19/27 (70%)  30/41 (73%) |36/36 (100%) 31/33 (94%)  34/35 (97%)  33/33 (100%) | 
|FIRST INCIDENCE    |     499          591          488          499         |526          597          459          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.047N*    P=0.038N*    P=0.051N     P=0.026N*   |P=0.423      P=0.548      P=0.474N     P=0.443      | 
|POLY 3             |     P=0.250N     P=0.144N     P=0.013N*    P=0.211N    |P=0.487      P=0.374N     P=0.574N     P=0.713      | 
|POLY 1.5           |     P=0.334N     P=0.206N     P=0.014N*    P=0.327N    |P=0.576N     P=0.350N     P=0.505N     P=0.592N     | 
|POLY 6             |     P=0.154N     P=0.077N     P=0.013N*    P=0.097N    |P=0.350      P=0.417N     P=0.663N     P=0.600      | 
|LOGISTIC REGRESSION|     P=0.131N     P=0.076N     P=0.013N*    P=0.157N    |P=0.564      P=0.295N     P=0.610N     P=0.583N     | 
|COCH-ARM / FISHERS |     P=0.451N     P=0.260N     P=0.012N*    P=0.500N    |P=0.387N     P=0.243N     P=0.346N     P=0.357N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  11/50 (22%)  11/50 (22%)  7/50 (14%)  |17/50 (34%)  21/50 (42%)  20/50 (40%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     10/43.05     11/45.17     11/40.13     7/47.85     |17/46.09     21/45.71     20/43.95     21/45.03     | 
|POLY-3 PERCENT (g) |     23.2%        24.4%        27.4%        14.6%       |36.9%        45.9%        45.5%        46.6%        | 
|TERMINAL (d)       |     7/31 (23%)   11/36 (31%)  10/27 (37%)  7/41 (17%)  |16/36 (44%)  17/33 (52%)  17/35 (49%)  17/33 (52%)  | 
|FIRST INCIDENCE    |     499          731 (T)      593          731 (T)     |690          618          470          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.550N     P=0.378      P=0.132N    |P=0.204      P=0.168      P=0.294      P=0.169      | 
|POLY 3             |     P=0.151N     P=0.550      P=0.426      P=0.218N    |P=0.238      P=0.250      P=0.267      P=0.229      | 
|POLY 1.5           |     P=0.180N     P=0.523      P=0.447      P=0.250N    |P=0.251      P=0.249      P=0.275      P=0.239      | 
|POLY 6             |     P=0.120N     P=0.583      P=0.393      P=0.183N    |P=0.227      P=0.248      P=0.270      P=0.219      | 
|LOGISTIC REGRESSION|     P=0.125N     P=0.588      P=0.445      P=0.244N    |P=0.213      P=0.202      P=0.240      P=0.187      | 
|COCH-ARM / FISHERS |     P=0.225N     P=0.500      P=0.500      P=0.298N    |P=0.287      P=0.268      P=0.339      P=0.268      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  10/50 (20%)  12/50 (24%)  12/50 (24%) |20/50 (40%)  21/50 (42%)  20/50 (40%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     10/42.91     10/45.17     12/39.67     12/47.85    |20/46.39     21/46.05     20/43.95     22/45.03     | 
|POLY-3 PERCENT (g) |     23.3%        22.1%        30.3%        25.1%       |43.1%        45.6%        45.5%        48.9%        | 
|TERMINAL (d)       |     7/31 (23%)   10/36 (28%)  12/27 (44%)  12/41 (29%) |18/36 (50%)  17/33 (52%)  17/35 (49%)  18/33 (55%)  | 
|FIRST INCIDENCE    |     499          731 (T)      731 (T)      731 (T)     |652          618          470          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.515N     P=0.452N     P=0.275      P=0.504N    |P=0.294      P=0.368      P=0.533      P=0.288      | 
|POLY 3             |     P=0.423      P=0.549N     P=0.320      P=0.519     |P=0.330      P=0.487      P=0.493      P=0.365      | 
|POLY 1.5           |     P=0.381      P=0.576N     P=0.346      P=0.471     |P=0.349      P=0.481      P=0.504      P=0.380      | 
|POLY 6             |     P=0.477      P=0.517N     P=0.280      P=0.576     |P=0.309      P=0.491      P=0.493      P=0.346      | 
|LOGISTIC REGRESSION|     P=0.536      P=0.508N     P=0.331      P=0.551     |P=0.313      P=0.443      P=0.466      P=0.322      | 
|COCH-ARM / FISHERS |     P=0.322      P=0.598N     P=0.405      P=0.405     |P=0.395      P=0.500      P=0.581N     P=0.420      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    4/50 (8%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/41.64      1/45.17      0/39.67      0/47.85     |0/45.91      4/45.04      1/43.08      2/44.77      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |0.0%         8.9%         2.3%         4.5%         | 
|TERMINAL (d)       |     0/31 (0%)    1/36 (3%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    3/33 (9%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          731 (T)      ---          ---         |---          652          709          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.530N     P=0.530      (e)          (e)         |P=0.404      P=0.056      P=0.500      P=0.232      | 
|POLY 3             |     P=0.551N     P=0.516      (e)          (e)         |P=0.406      P=0.058      P=0.487      P=0.232      | 
|POLY 1.5           |     P=0.560N     P=0.508      (e)          (e)         |P=0.409      P=0.058      P=0.489      P=0.233      | 
|POLY 6             |     P=0.538N     P=0.526      (e)          (e)         |P=0.402      P=0.057      P=0.487      P=0.230      | 
|LOGISTIC REGRESSION|     (e)          P=0.530      (e)          (e)         |P=0.426      P=0.060      P=0.492      P=0.278      | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.423      P=0.059      P=0.500      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/20 (0%)    4/28 (14%)   4/28 (14%)   2/20 (10%)  |0/25 (0%)    1/26 (4%)    3/24 (13%)   0/27 (0%)    | 
|POLY-3 RATE (b)    |     0/16.32      4/25.68      4/24.19      2/19.69     |0/23.04      1/23.53      3/21.65      0/24.77      | 
|POLY-3 PERCENT (g) |     0.0%         15.6%        16.5%        10.2%       |0.0%         4.3%         13.9%        0.0%         | 
|TERMINAL (d)       |     0/11 (0%)    4/19 (21%)   3/18 (17%)   1/17 (6%)   |0/19 (0%)    0/17 (0%)    1/17 (6%)    0/20 (0%)    | 
|FIRST INCIDENCE    |     ---          731 (T)      677          675         |---          675          632          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.493      P=0.145      P=0.113      P=0.327     |P=0.628      P=0.486      P=0.114      (e)          | 
|POLY 3             |     P=0.434      P=0.128      P=0.114      P=0.278     |P=0.618N     P=0.504      P=0.101      (e)          | 
|POLY 1.5           |     P=0.384      P=0.118      P=0.110      P=0.258     |P=0.618N     P=0.506      P=0.103      (e)          | 
|POLY 6             |     P=0.506      P=0.140      P=0.120      P=0.306     |P=0.616N     P=0.501      P=0.102      (e)          | 
|LOGISTIC REGRESSION|     P=0.430      P=0.145      P=0.121      P=0.227     |P=0.614N     P=0.517      P=0.115      (e)          | 
|COCH-ARM / FISHERS |     P=0.320      P=0.105      P=0.105      P=0.244     |P=0.615N     P=0.510      P=0.110      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/20 (5%)    4/28 (14%)   4/28 (14%)   3/20 (15%)  |0/25 (0%)    1/26 (4%)    3/24 (13%)   3/27 (11%)   | 
|POLY-3 RATE (b)    |     1/16.32      4/25.68      4/24.17      3/19.69     |0/23.04      1/23.53      3/21.65      3/25.12      | 
|POLY-3 PERCENT (g) |     6.1%         15.6%        16.6%        15.2%       |0.0%         4.3%         13.9%        11.9%        | 
|TERMINAL (d)       |     1/11 (9%)    4/19 (21%)   3/18 (17%)   2/17 (12%)  |0/19 (0%)    0/17 (0%)    1/17 (6%)    2/20 (10%)   | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      682          675         |---          675          632          634          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.475      P=0.370      P=0.302      P=0.460     |P=0.074      P=0.486      P=0.114      P=0.124      | 
|POLY 3             |     P=0.382      P=0.336      P=0.310      P=0.372     |P=0.077      P=0.504      P=0.101      P=0.130      | 
|POLY 1.5           |     P=0.340      P=0.316      P=0.301      P=0.341     |P=0.076      P=0.506      P=0.103      P=0.129      | 
|POLY 6             |     P=0.444      P=0.358      P=0.322      P=0.415     |P=0.080      P=0.501      P=0.102      P=0.132      | 
|LOGISTIC REGRESSION|     P=0.419      P=0.370      P=0.322      P=0.386     |P=0.074      P=0.517      P=0.115      P=0.132      | 
|COCH-ARM / FISHERS |     P=0.287      P=0.297      P=0.297      P=0.302     |P=0.075      P=0.510      P=0.110      P=0.132      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |4/50 (8%)    3/50 (6%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.64      0/45.17      0/39.67      0/47.85     |4/46.28      3/44.73      3/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |8.6%         6.7%         7.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |3/36 (8%)    3/33 (9%)    3/35 (9%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |632          735 (T)      735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.057N     P=0.544N     P=0.520N     P=0.075N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.056N     P=0.518N     P=0.540N     P=0.066N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.054N     P=0.514N     P=0.533N     P=0.065N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.057N     P=0.527N     P=0.545N     P=0.069N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.056N     P=0.516N     P=0.535N     P=0.064N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.051N     P=0.500N     P=0.511N     P=0.059N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/50 (94%)  41/50 (82%)  45/50 (90%)  47/50 (94%) |47/50 (94%)  45/50 (90%)  37/49 (76%)  42/50 (84%)  | 
|POLY-3 RATE (b)    |     47/49.57     41/49.84     45/47.44     47/49.41    |47/49.06     45/47.91     37/44.84     42/48.75     | 
|POLY-3 PERCENT (g) |     94.8%        82.3%        94.9%        95.1%       |95.8%        93.9%        82.5%        86.2%        | 
|TERMINAL (d)       |     29/31 (94%)  28/36 (78%)  26/27 (96%)  41/41 (100%)|35/36 (97%)  33/33 (100%) 30/35 (86%)  27/33 (82%)  | 
|FIRST INCIDENCE    |     429          170          488          499         |526          597          498          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.037N*    P=0.402      P=0.015N*   |P=0.309N     P=0.463      P=0.066N     P=0.462N     | 
|POLY 3             |     P=0.232      P=0.045N*    P=0.681      P=0.662     |P=0.036N*    P=0.518N     P=0.026N*    P=0.086N     | 
|POLY 1.5           |     P=0.258      P=0.051N     P=0.640N     P=0.665     |P=0.048N*    P=0.491N     P=0.018N*    P=0.102N     | 
|POLY 6             |     P=0.190      P=0.040N*    P=0.674      P=0.637     |P=0.023N*    P=0.576N     P=0.040N*    P=0.066N     | 
|LOGISTIC REGRESSION|     P=0.386      P=0.091N     P=0.527N     P=0.608N    |P=0.104N     P=0.427N     P=0.028N*    P=0.148N     | 
|COCH-ARM / FISHERS |     P=0.316      P=0.061N     P=0.357N     P=0.661N    |P=0.065N     P=0.357N     P=0.010N*    P=0.100N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/5 (40%)    3/8 (38%)    6/9 (67%)    9/12 (75%)  |8/9 (89%)    4/6 (67%)    8/9 (89%)    7/8 (88%)    | 
|POLY-3 RATE (b)    |     2/4.43       3/7.30       6/7.62       9/11.76     |8/8.83       4/5.76       8/9.00       7/8.00       | 
|POLY-3 PERCENT (g) |     45.1%        41.1%        78.8%        76.6%       |90.6%        69.4%        88.9%        87.5%        | 
|TERMINAL (d)       |     2/3 (67%)    3/5 (60%)    6/6 (100%)   8/10 (80%)  |6/6 (100%)   1/2 (50%)    6/7 (86%)    7/8 (88%)    | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      731 (T)      691         |597          675          613          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.191      P=0.702N     P=0.362      P=0.390     |P=0.158N     P=0.599N     P=0.539N     P=0.152N     | 
|POLY 3             |     P=0.081      P=0.673N     P=0.269      P=0.270     |P=0.590      P=0.366N     P=0.741N     P=0.714N     | 
|POLY 1.5           |     P=0.071      P=0.674N     P=0.304      P=0.238     |P=0.561      P=0.359N     P=0.751N     P=0.724N     | 
|POLY 6             |     P=0.109      P=0.671N     P=0.229      P=0.335     |P=0.637N     P=0.380N     P=0.719N     P=0.692N     | 
|LOGISTIC REGRESSION|     P=0.205      P=0.702N     P=0.362      P=0.463     |P=0.563      P=0.349N     P=0.774N     P=0.721N     | 
|COCH-ARM / FISHERS |     P=0.064      P=0.685N     P=0.343      P=0.205     |P=0.532      P=0.341N     P=0.765N     P=0.735N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/5 (40%)    2/8 (25%)    5/9 (56%)    6/12 (50%)  |5/9 (56%)    2/6 (33%)    5/9 (56%)    3/8 (38%)    | 
|POLY-3 RATE (b)    |     2/4.43       2/7.30       5/7.62       6/11.60     |5/8.36       2/5.61       5/8.38       3/8.00       | 
|POLY-3 PERCENT (g) |     45.1%        27.4%        65.6%        51.7%       |59.8%        35.6%        59.7%        37.5%        | 
|TERMINAL (d)       |     2/3 (67%)    2/5 (40%)    5/6 (83%)    6/10 (60%)  |4/6 (67%)    0/2 (0%)     5/7 (71%)    3/8 (38%)    | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      731 (T)      731 (T)     |690          675          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.568      P=0.500N     P=0.605      P=0.674N    |P=0.133N     P=0.514N     P=0.566N     P=0.183N     | 
|POLY 3             |     P=0.351      P=0.506N     P=0.463      P=0.620     |P=0.330N     P=0.369N     P=0.686N     P=0.346N     | 
|POLY 1.5           |     P=0.324      P=0.511N     P=0.477      P=0.591     |P=0.358N     P=0.373N     P=0.680N     P=0.371N     | 
|POLY 6             |     P=0.404      P=0.496N     P=0.460      P=0.667     |P=0.287N     P=0.370N     P=0.696      P=0.309N     | 
|LOGISTIC REGRESSION|     P=0.568      P=0.500N     P=0.605      P=0.674N    |P=0.205N     P=0.408N     P=0.641N     P=0.256N     | 
|COCH-ARM / FISHERS |     P=0.292      P=0.510N     P=0.500      P=0.563     |P=0.384N     P=0.378N     P=0.681N     P=0.399N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/5 (40%)    3/8 (38%)    8/9 (89%)    10/12 (83%) |7/9 (78%)    5/6 (83%)    9/9 (100%)   7/8 (88%)    | 
|POLY-3 RATE (b)    |     2/4.43       3/7.30       8/8.51       10/11.76    |7/8.83       5/5.76       9/9.00       7/8.00       | 
|POLY-3 PERCENT (g) |     45.1%        41.1%        94.0%        85.1%       |79.3%        86.8%        100.0%       87.5%        | 
|TERMINAL (d)       |     2/3 (67%)    3/5 (60%)    6/6 (100%)   9/10 (90%)  |5/6 (83%)    2/2 (100%)   7/7 (100%)   7/8 (88%)    | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      535          691         |597          675          613          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.102      P=0.702N     P=0.085      P=0.270     |P=0.197N     P=0.401      P=0.461      P=0.373N     | 
|POLY 3             |     P=0.022 *    P=0.673N     P=0.055      P=0.144     |P=0.418      P=0.629      P=0.245      P=0.578      | 
|POLY 1.5           |     P=0.019 *    P=0.674N     P=0.062      P=0.123     |P=0.391      P=0.636      P=0.235      P=0.561      | 
|POLY 6             |     P=0.033 *    P=0.671N     P=0.056      P=0.192     |P=0.472      P=0.616      P=0.268      P=0.609      | 
|LOGISTIC REGRESSION|     P=0.047 *    P=0.702N     P=0.052      P=0.328     |P=0.412      P=0.651      P=0.226      P=0.562      | 
|COCH-ARM / FISHERS |     P=0.025 *    P=0.685N     P=0.095      P=0.117     |P=0.361      P=0.659      P=0.235      P=0.547      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    4/50 (8%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.52      1/45.17      4/39.67      3/48.53     |0/45.91      0/44.73      0/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     4.7%         2.2%         10.1%        6.2%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/31 (0%)    1/36 (3%)    4/27 (15%)   2/41 (5%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     598          731 (T)      731 (T)      499         |---          ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.383      P=0.459N     P=0.292      P=0.581     |P=0.192      (e)          (e)          P=0.483      | 
|POLY 3             |     P=0.352      P=0.479N     P=0.305      P=0.560     |P=0.195      (e)          (e)          P=0.492      | 
|POLY 1.5           |     P=0.328      P=0.490N     P=0.314      P=0.536     |P=0.197      (e)          (e)          P=0.494      | 
|POLY 6             |     P=0.379      P=0.466N     P=0.289      P=0.587     |P=0.194      (e)          (e)          P=0.490      | 
|LOGISTIC REGRESSION|     P=0.280      P=0.509N     P=0.321      P=0.228     |(e)          (e)          (e)          P=0.483      | 
|COCH-ARM / FISHERS |     P=0.292      P=0.500N     P=0.339      P=0.500     |P=0.199      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    3/50 (6%)    4/50 (8%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/42.86      2/45.17      3/40.06      4/48.66     |1/46.16      0/44.73      0/42.98      2/44.16      | 
|POLY-3 PERCENT (g) |     9.3%         4.4%         7.5%         8.2%        |2.2%         0.0%         0.0%         4.5%         | 
|TERMINAL (d)       |     1/31 (3%)    2/36 (6%)    1/27 (4%)    2/41 (5%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     598          731 (T)      677          499         |670          ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.557N     P=0.278N     P=0.545N     P=0.519N    |P=0.230      P=0.509N     P=0.524N     P=0.466      | 
|POLY 3             |     P=0.535      P=0.313N     P=0.537N     P=0.572N    |P=0.242      P=0.506N     P=0.514N     P=0.485      | 
|POLY 1.5           |     P=0.514      P=0.326N     P=0.527N     P=0.601N    |P=0.243      P=0.505N     P=0.512N     P=0.489      | 
|POLY 6             |     P=0.561      P=0.299N     P=0.553N     P=0.538N    |P=0.241      P=0.509N     P=0.516N     P=0.479      | 
|LOGISTIC REGRESSION|     P=0.457      P=0.348N     P=0.498N     P=0.406     |P=0.240      P=0.482N     P=0.482N     P=0.490      | 
|COCH-ARM / FISHERS |     P=0.481      P=0.339N     P=0.500N     P=0.643N    |P=0.246      P=0.500N     P=0.505N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    6/50 (12%)   2/50 (4%)   |3/50 (6%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.43      3/45.72      6/40.67      2/48.27     |3/47.16      0/44.73      1/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     4.7%         6.6%         14.8%        4.1%        |6.4%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    1/36 (3%)    2/27 (7%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     577          593          609          633         |526          ---          734          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.481N     P=0.563      P=0.119      P=0.605N    |P=0.097N     P=0.131N     P=0.337N     P=0.134N     | 
|POLY 3             |     P=0.515N     P=0.534      P=0.118      P=0.646N    |P=0.086N     P=0.128N     P=0.339N     P=0.131N     | 
|POLY 1.5           |     P=0.548N     P=0.517      P=0.121      P=0.666N    |P=0.086N     P=0.126N     P=0.331N     P=0.127N     | 
|POLY 6             |     P=0.475N     P=0.554      P=0.113      P=0.622N    |P=0.086N     P=0.133N     P=0.346N     P=0.136N     | 
|LOGISTIC REGRESSION|     P=0.528      P=0.486      P=0.134      P=0.516     |P=0.073N     P=0.067N     P=0.225N     P=0.059N     | 
|COCH-ARM / FISHERS |     P=0.558      P=0.500      P=0.134      P=0.691N    |P=0.087N     P=0.121N     P=0.316N     P=0.121N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    5/50 (10%)   9/50 (18%)  |5/50 (10%)   3/50 (6%)    6/49 (12%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/42.35      4/45.17      5/41.44      9/47.98     |5/46.55      3/44.73      6/43.89      2/44.70      | 
|POLY-3 PERCENT (g) |     14.2%        8.9%         12.1%        18.8%       |10.7%        6.7%         13.7%        4.5%         | 
|TERMINAL (d)       |     3/31 (10%)   4/36 (11%)   1/27 (4%)    8/41 (20%)  |4/36 (11%)   3/33 (9%)    2/35 (6%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     637          731 (T)      535          698         |523          735 (T)      613          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.288      P=0.277N     P=0.559N     P=0.511     |P=0.272N     P=0.400N     P=0.470      P=0.247N     | 
|POLY 3             |     P=0.194      P=0.329N     P=0.515N     P=0.382     |P=0.257N     P=0.378N     P=0.459      P=0.233N     | 
|POLY 1.5           |     P=0.176      P=0.349N     P=0.516N     P=0.342     |P=0.253N     P=0.373N     P=0.463      P=0.229N     | 
|POLY 6             |     P=0.217      P=0.307N     P=0.519N     P=0.430     |P=0.260N     P=0.387N     P=0.464      P=0.237N     | 
|LOGISTIC REGRESSION|     P=0.173      P=0.310N     P=0.494N     P=0.412     |P=0.238N     P=0.360N     P=0.506      P=0.185N     | 
|COCH-ARM / FISHERS |     P=0.151      P=0.370N     P=0.500N     P=0.288     |P=0.242N     P=0.357N     P=0.486      P=0.218N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa                                                                                                                      | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/13 (92%)  12/14 (86%)  10/12 (83%)  22/24 (92%) |9/11 (82%)   24/24 (100%) 17/18 (94%)  4/5 (80%)    | 
|POLY-3 RATE (b)    |     12/13.00     12/13.17     10/11.39     22/23.87    |9/11.00      24/24.00     17/17.64     4/4.74       | 
|POLY-3 PERCENT (g) |     92.3%        91.1%        87.8%        92.2%       |81.8%        100.0%       96.4%        84.4%        | 
|TERMINAL (d)       |     10/11 (91%)  11/12 (92%)  8/9 (89%)    21/22 (96%) |8/10 (80%)   17/17 (100%) 14/14 (100%) 2/2 (100%)   | 
|FIRST INCIDENCE    |     429          725          488          666         |620          85           543          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.553N     P=0.482N     P=0.638N     P=0.563N    |P=0.498      P=0.007 **   P=0.076      P=0.358      | 
|POLY 3             |     P=0.592      P=0.724N     P=0.621N     P=0.733N    |P=0.619      P=0.077      P=0.250      P=0.717      | 
|POLY 1.5           |     P=0.570      P=0.666N     P=0.559N     P=0.721N    |P=0.698      P=0.077      P=0.284      P=0.742      | 
|POLY 6             |     P=0.593      P=0.755N     P=0.685N     P=0.734     |P=0.457      P=0.077      P=0.202      P=0.669      | 
|LOGISTIC REGRESSION|     P=0.546N     P=0.518N     P=0.495N     P=0.724N    |P=0.598N     (e)          P=0.287      P=0.755N     | 
|COCH-ARM / FISHERS |     P=0.511      P=0.529N     P=0.469N     P=0.740     |P=0.599N     P=0.092      P=0.316      P=0.705N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/13 (31%)   9/14 (64%)   6/12 (50%)   12/24 (50%) |8/11 (73%)   8/24 (33%)   3/18 (17%)   1/5 (20%)    | 
|POLY-3 RATE (b)    |     4/11.90      9/13.98      6/10.69      12/23.76    |8/11.00      8/22.06      3/17.20      1/4.58       | 
|POLY-3 PERCENT (g) |     33.6%        64.4%        56.1%        50.5%       |72.7%        36.3%        17.4%        21.8%        | 
|TERMINAL (d)       |     4/11 (36%)   8/12 (67%)   5/9 (56%)    11/22 (50%) |7/10 (70%)   5/17 (29%)   1/14 (7%)    0/2 (0%)     | 
|FIRST INCIDENCE    |     731 (T)      404          535          698         |620          561          632          723          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.422      P=0.093      P=0.220      P=0.263     |P=0.032N*    P=0.264N     P=0.037N*    P=0.256N     | 
|POLY 3             |     P=0.458      P=0.119      P=0.258      P=0.279     |P=0.008N**   P=0.045N*    P=0.002N**   P=0.087N     | 
|POLY 1.5           |     P=0.428      P=0.104      P=0.270      P=0.258     |P=0.008N**   P=0.040N*    P<0.001N**   P=0.075N     | 
|POLY 6             |     P=0.483      P=0.134      P=0.248      P=0.299     |P=0.008N**   P=0.052N     P=0.002N**   P=0.115N     | 
|LOGISTIC REGRESSION|     P=0.405      P=0.088      P=0.230      P=0.292     |P=0.013N*    P=0.043N*    P=0.003N**   P=0.076N     | 
|COCH-ARM / FISHERS |     P=0.373      P=0.087      P=0.284      P=0.219     |P=0.013N*    P=0.035N*    P=0.004N**   P=0.077N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   5/50 (10%)   4/49 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |5/46.05      5/45.44      4/42.98      2/44.16      | 
|POLY-3 PERCENT (g) |                                                        |10.9%        11.0%        9.3%         4.5%         | 
|TERMINAL (d)       |                                                        |3/36 (8%)    3/33 (9%)    4/35 (11%)   2/33 (6%)    | 
|FIRST INCIDENCE    |                                                        |702          597          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.171N     P=0.581      P=0.515N     P=0.256N     | 
|POLY 3             |                                                        |P=0.163N     P=0.622      P=0.543N     P=0.233N     | 
|POLY 1.5           |                                                        |P=0.158N     P=0.621      P=0.536N     P=0.229N     | 
|POLY 6             |                                                        |P=0.168N     P=0.621      P=0.546N     P=0.239N     | 
|LOGISTIC REGRESSION|                                                        |P=0.161N     P=0.622      P=0.534N     P=0.241N     | 
|COCH-ARM / FISHERS |                                                        |P=0.146N     P=0.630N     P=0.513N     P=0.218N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.64      2/45.17      0/39.67      0/47.85     |0/45.91      0/44.73      1/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     2.4%         4.4%         0.0%         0.0%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/36 (6%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    1/35 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      ---          ---         |---          ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.160N     P=0.552      P=0.528N     P=0.444N    |P=0.686      (e)          P=0.494      (e)          | 
|POLY 3             |     P=0.172N     P=0.528      P=0.510N     P=0.472N    |P=0.682      (e)          P=0.487      (e)          | 
|POLY 1.5           |     P=0.179N     P=0.514      P=0.508N     P=0.484N    |P=0.685      (e)          P=0.489      (e)          | 
|POLY 6             |     P=0.161N     P=0.546      P=0.513N     P=0.458N    |P=0.677      (e)          P=0.486      (e)          | 
|LOGISTIC REGRESSION|     P=0.160N     P=0.552      (e)          (e)         |(e)          (e)          P=0.494      (e)          | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.694      (e)          P=0.495      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.64      1/45.17      0/39.67      1/47.85     |0/45.91      0/44.73      2/43.11      1/44.16      | 
|POLY-3 PERCENT (g) |     2.4%         2.2%         0.0%         2.1%        |0.0%         0.0%         4.6%         2.3%         | 
|TERMINAL (d)       |     1/31 (3%)    1/36 (3%)    0/27 (0%)    1/41 (2%)   |0/36 (0%)    0/33 (0%)    1/35 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      ---          731 (T)     |---          ---          702          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.553N     P=0.728N     P=0.528N     P=0.698N    |P=0.236      (e)          P=0.237      P=0.483      | 
|POLY 3             |     P=0.608N     P=0.742N     P=0.510N     P=0.729N    |P=0.234      (e)          P=0.223      P=0.492      | 
|POLY 1.5           |     P=0.613N     P=0.752N     P=0.508N     P=0.742N    |P=0.238      (e)          P=0.225      P=0.494      | 
|POLY 6             |     P=0.602N     P=0.730N     P=0.513N     P=0.711N    |P=0.230      (e)          P=0.223      P=0.490      | 
|LOGISTIC REGRESSION|     P=0.553N     P=0.728N     (e)          P=0.698N    |P=0.236      (e)          P=0.224      P=0.483      | 
|COCH-ARM / FISHERS |     P=0.616N     P=0.753N     P=0.500N     P=0.753N    |P=0.246      (e)          P=0.242      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     25/50 (50%)  20/50 (40%)  23/50 (46%)  16/50 (32%) |14/50 (28%)  14/50 (28%)  5/49 (10%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     25/45.12     20/45.75     23/42.51     16/47.94    |14/46.46     14/45.98     5/42.98      11/46.07     | 
|POLY-3 PERCENT (g) |     55.4%        43.7%        54.1%        33.4%       |30.1%        30.5%        11.6%        23.9%        | 
|TERMINAL (d)       |     16/31 (52%)  17/36 (47%)  15/27 (56%)  15/41 (37%) |12/36 (33%)  10/33 (30%)  5/35 (14%)   5/33 (15%)   | 
|FIRST INCIDENCE    |     499          648          506          709         |652          597          735 (T)      568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010N*    P=0.089N     P=0.528      P=0.006N**  |P=0.236N     P=0.499      P=0.024N*    P=0.414N     | 
|POLY 3             |     P=0.028N*    P=0.178N     P=0.538N     P=0.024N*   |P=0.184N     P=0.577      P=0.028N*    P=0.329N     | 
|POLY 1.5           |     P=0.038N*    P=0.198N     P=0.508N     P=0.032N*   |P=0.185N     P=0.573      P=0.026N*    P=0.333N     | 
|POLY 6             |     P=0.019N*    P=0.158N     P=0.578N     P=0.017N*   |P=0.179N     P=0.577      P=0.029N*    P=0.320N     | 
|LOGISTIC REGRESSION|     P=0.025N*    P=0.143N     P=0.492N     P=0.026N*   |P=0.196N     P=0.560      P=0.028N*    P=0.332N     | 
|COCH-ARM / FISHERS |     P=0.061N     P=0.211N     P=0.421N     P=0.052N    |P=0.180N     P=0.588N     P=0.022N*    P=0.322N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.64      2/45.17      1/39.85      0/47.85     |1/45.91      1/44.88      0/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.5%         0.0%        |2.2%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/31 (0%)    2/36 (6%)    0/27 (0%)    0/41 (0%)   |1/36 (3%)    0/33 (0%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          731 (T)      682          ---         |735 (T)      697          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.403N     P=0.272      P=0.481      (e)         |P=0.628N     P=0.751      P=0.506N     P=0.742      | 
|POLY 3             |     P=0.410N     P=0.256      P=0.491      (e)         |P=0.621N     P=0.756      P=0.513N     P=0.752      | 
|POLY 1.5           |     P=0.432N     P=0.246      P=0.493      (e)         |P=0.619N     P=0.756      P=0.511N     P=0.754      | 
|POLY 6             |     P=0.382N     P=0.268      P=0.489      (e)         |P=0.621N     P=0.754      P=0.514N     P=0.749      | 
|LOGISTIC REGRESSION|     P=0.425N     P=0.272      P=0.495      (e)         |P=0.627N     P=0.758      (e)          P=0.742      | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247      P=0.500      (e)         |P=0.616N     P=0.753N     P=0.505N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    7/50 (14%)   3/50 (6%)    10/50 (20%) |8/50 (16%)   4/50 (8%)    4/49 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/42.07      7/45.36      3/40.32      10/47.85    |8/46.61      4/44.96      4/42.98      1/44.49      | 
|POLY-3 PERCENT (g) |     7.1%         15.4%        7.4%         20.9%       |17.2%        8.9%         9.3%         2.3%         | 
|TERMINAL (d)       |     2/31 (7%)    6/36 (17%)   1/27 (4%)    10/41 (24%) |6/36 (17%)   3/33 (9%)    4/35 (11%)   0/33 (0%)    | 
|FIRST INCIDENCE    |     606          682          593          731 (T)     |620          675          735 (T)      643          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.102      P=0.229      P=0.617      P=0.100     |P=0.020N*    P=0.219N     P=0.200N     P=0.027N*    | 
|POLY 3             |     P=0.056      P=0.189      P=0.643      P=0.059     |P=0.016N*    P=0.194N     P=0.218N     P=0.019N*    | 
|POLY 1.5           |     P=0.047 *    P=0.173      P=0.646      P=0.048 *   |P=0.015N*    P=0.190N     P=0.210N     P=0.018N*    | 
|POLY 6             |     P=0.068      P=0.210      P=0.638      P=0.075     |P=0.016N*    P=0.202N     P=0.224N     P=0.020N*    | 
|LOGISTIC REGRESSION|     P=0.071      P=0.201      P=0.655      P=0.081     |P=0.016N*    P=0.186N     P=0.208N     P=0.017N*    | 
|COCH-ARM / FISHERS |     P=0.039 *    P=0.159      P=0.661N     P=0.036 *   |P=0.015N*    P=0.178N     P=0.188N     P=0.015N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    3/50 (6%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.09      0/45.17      0/39.67      1/47.85     |2/45.91      3/44.97      1/43.67      0/44.16      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         2.1%        |4.4%         6.7%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    1/41 (2%)   |2/36 (6%)    2/33 (6%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     598          ---          ---          731 (T)     |735 (T)      671          498          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.627      P=0.482N     P=0.510N     P=0.712N    |P=0.116N     P=0.466      P=0.516N     P=0.258N     | 
|POLY 3             |     P=0.604      P=0.486N     P=0.512N     P=0.731N    |P=0.111N     P=0.491      P=0.517N     P=0.246N     | 
|POLY 1.5           |     P=0.601      P=0.493N     P=0.509N     P=0.744N    |P=0.109N     P=0.492      P=0.516N     P=0.244N     | 
|POLY 6             |     P=0.608      P=0.477N     P=0.517N     P=0.716N    |P=0.113N     P=0.488      P=0.516N     P=0.249N     | 
|LOGISTIC REGRESSION|     P=0.583      P=0.490N     P=0.462N     P=0.708     |P=0.099N     P=0.484      P=0.449N     (e)          | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.104N     P=0.500      P=0.508N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   3/50 (6%)    4/50 (8%)   |27/50 (54%)  27/50 (54%)  19/49 (39%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     4/42.82      6/45.69      3/39.67      4/48.07     |27/48.21     27/46.16     19/44.69     22/45.58     | 
|POLY-3 PERCENT (g) |     9.3%         13.1%        7.6%         8.3%        |56.0%        58.5%        42.5%        48.3%        | 
|TERMINAL (d)       |     2/31 (7%)    4/36 (11%)   3/27 (11%)   3/41 (7%)   |19/36 (53%)  20/33 (61%)  15/35 (43%)  16/33 (49%)  | 
|FIRST INCIDENCE    |     505          648          731 (T)      672         |526          620          177          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.323N     P=0.464      P=0.558N     P=0.511N    |P=0.213N     P=0.432      P=0.132N     P=0.355N     | 
|POLY 3             |     P=0.391N     P=0.411      P=0.542N     P=0.578N    |P=0.166N     P=0.485      P=0.134N     P=0.292N     | 
|POLY 1.5           |     P=0.417N     P=0.389      P=0.530N     P=0.606N    |P=0.149N     P=0.512      P=0.117N     P=0.264N     | 
|POLY 6             |     P=0.360N     P=0.440      P=0.560N     P=0.543N    |P=0.191N     P=0.444      P=0.155N     P=0.332N     | 
|LOGISTIC REGRESSION|     P=0.425N     P=0.359      P=0.508N     P=0.530     |P=0.146N     P=0.536      P=0.099N     P=0.249N     | 
|COCH-ARM / FISHERS |     P=0.449N     P=0.370      P=0.500N     P=0.643N    |P=0.123N     P=0.579N     P=0.094N     P=0.212N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  16/50 (32%)  18/50 (36%)  21/50 (42%) |19/50 (38%)  21/50 (42%)  23/49 (47%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     13/43.99     16/46.34     18/41.34     21/48.33    |19/46.53     21/46.42     23/43.55     21/44.93     | 
|POLY-3 PERCENT (g) |     29.6%        34.5%        43.6%        43.5%       |40.8%        45.2%        52.8%        46.7%        | 
|TERMINAL (d)       |     8/31 (26%)   12/36 (33%)  14/27 (52%)  19/41 (46%) |17/36 (47%)  15/33 (46%)  21/35 (60%)  17/33 (52%)  | 
|FIRST INCIDENCE    |     499          593          577          633         |597          618          632          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.238      P=0.513      P=0.119      P=0.301     |P=0.283      P=0.311      P=0.216      P=0.291      | 
|POLY 3             |     P=0.086      P=0.389      P=0.127      P=0.119     |P=0.303      P=0.413      P=0.173      P=0.359      | 
|POLY 1.5           |     P=0.071      P=0.355      P=0.144      P=0.095     |P=0.328      P=0.404      P=0.190      P=0.375      | 
|POLY 6             |     P=0.109      P=0.436      P=0.107      P=0.155     |P=0.278      P=0.425      P=0.166      P=0.341      | 
|LOGISTIC REGRESSION|     P=0.096      P=0.348      P=0.158      P=0.095     |P=0.300      P=0.377      P=0.171      P=0.328      | 
|COCH-ARM / FISHERS |     P=0.053      P=0.330      P=0.194      P=0.069     |P=0.382      P=0.419      P=0.243      P=0.419      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/41.64      0/45.17      2/40.13      0/47.85     |0/45.91      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     4.8%         0.0%         5.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/31 (7%)    0/36 (0%)    1/27 (4%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     731 (T)      ---          593          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.210N     P=0.206N     P=0.654      P=0.179N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.229N     P=0.219N     P=0.681      P=0.208N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.235N     P=0.228N     P=0.683      P=0.220N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.222N     P=0.209N     P=0.678      P=0.194N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.239N     (e)          P=0.680      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.248N     P=0.247N     P=0.691N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    2/50 (4%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     0/41.64      2/44.35      2/39.67      3/47.85     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         5.0%         6.3%        |                                                    | 
|TERMINAL (d)       |     0/31 (0%)    1/36 (3%)    2/27 (7%)    3/41 (7%)   |                                                    | 
|FIRST INCIDENCE    |     ---          725          731 (T)      731 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.170      P=0.276      P=0.208      P=0.175     |                                                    | 
|POLY 3             |     P=0.145      P=0.251      P=0.226      P=0.146     |                                                    | 
|POLY 1.5           |     P=0.130      P=0.242      P=0.229      P=0.134     |                                                    | 
|POLY 6             |     P=0.165      P=0.264      P=0.222      P=0.161     |                                                    | 
|LOGISTIC REGRESSION|     P=0.167      P=0.272      P=0.208      P=0.175     |                                                    | 
|COCH-ARM / FISHERS |     P=0.110      P=0.242      P=0.247      P=0.121     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     43/50 (86%)  47/49 (96%)  43/50 (86%)  49/50 (98%) |                                                    | 
|POLY-3 RATE (b)    |     43/46.74     47/47.18     43/46.27     49/50.00    |                                                    | 
|POLY-3 PERCENT (g) |     92.0%        99.6%        92.9%        98.0%       |                                                    | 
|TERMINAL (d)       |     30/31 (97%)  36/36 (100%) 27/27 (100%) 40/41 (98%) |                                                    | 
|FIRST INCIDENCE    |     505          591          488          499         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.157N     P=0.364N     P=0.259      P=0.146N    |                                                    | 
|POLY 3             |     P=0.208      P=0.046 *    P=0.603      P=0.149     |                                                    | 
|POLY 1.5           |     P=0.111      P=0.037 *    P=0.543      P=0.071     |                                                    | 
|POLY 6             |     P=0.411      P=0.114      P=0.694      P=0.349     |                                                    | 
|LOGISTIC REGRESSION|     P=0.227      P=0.157      P=0.444      P=0.227     |                                                    | 
|COCH-ARM / FISHERS |     P=0.066      P=0.085      P=0.613N     P=0.030 *   |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland: Duct                                                                                                            | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   7/49 (14%)   6/50 (12%)   9/50 (18%)  |                                                    | 
|POLY-3 RATE (b)    |     7/42.98      7/44.67      6/41.02      9/48.47     |                                                    | 
|POLY-3 PERCENT (g) |     16.3%        15.7%        14.6%        18.6%       |                                                    | 
|TERMINAL (d)       |     4/31 (13%)   5/36 (14%)   3/27 (11%)   6/41 (15%)  |                                                    | 
|FIRST INCIDENCE    |     577          643          535          666         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.516      P=0.496N     P=0.566N     P=0.589N    |                                                    | 
|POLY 3             |     P=0.415      P=0.584N     P=0.536N     P=0.496     |                                                    | 
|POLY 1.5           |     P=0.382      P=0.607N     P=0.529N     P=0.453     |                                                    | 
|POLY 6             |     P=0.459      P=0.554N     P=0.549N     P=0.549     |                                                    | 
|LOGISTIC REGRESSION|     P=0.356      P=0.612N     P=0.502N     P=0.366     |                                                    | 
|COCH-ARM / FISHERS |     P=0.335      P=0.597      P=0.500N     P=0.393     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/49 (2%)    1/49 (2%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     3/42.58      1/44.33      1/38.67      1/47.85     |                                                    | 
|POLY-3 PERCENT (g) |     7.1%         2.3%         2.6%         2.1%        |                                                    | 
|TERMINAL (d)       |     1/31 (3%)    1/36 (3%)    1/26 (4%)    1/41 (2%)   |                                                    | 
|FIRST INCIDENCE    |     508          731 (T)      731 (T)      731 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.196N     P=0.260N     P=0.344N     P=0.229N    |                                                    | 
|POLY 3             |     P=0.231N     P=0.291N     P=0.340N     P=0.265N    |                                                    | 
|POLY 1.5           |     P=0.236N     P=0.302N     P=0.332N     P=0.282N    |                                                    | 
|POLY 6             |     P=0.225N     P=0.277N     P=0.353N     P=0.246N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.245N     P=0.322N     P=0.302N     P=0.441N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.241N     P=0.316N     P=0.316N     P=0.309N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  20/49 (41%)  20/49 (41%)  15/50 (30%) |                                                    | 
|POLY-3 RATE (b)    |     23/46.81     20/45.96     20/42.54     15/49.13    |                                                    | 
|POLY-3 PERCENT (g) |     49.1%        43.5%        47.0%        30.5%       |                                                    | 
|TERMINAL (d)       |     13/31 (42%)  16/36 (44%)  10/26 (39%)  11/41 (27%) |                                                    | 
|FIRST INCIDENCE    |     499          404          488          499         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.020N*    P=0.192N     P=0.529N     P=0.018N*   |                                                    | 
|POLY 3             |     P=0.037N*    P=0.369N     P=0.505N     P=0.047N*   |                                                    | 
|POLY 1.5           |     P=0.045N*    P=0.379N     P=0.469N     P=0.056N    |                                                    | 
|POLY 6             |     P=0.028N*    P=0.359N     P=0.548N     P=0.037N*   |                                                    | 
|LOGISTIC REGRESSION|     P=0.070N     P=0.403N     P=0.369N     P=0.230N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.062N     P=0.376N     P=0.376N     P=0.074N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Epithelium                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/49 (2%)    8/49 (16%)   6/50 (12%)  |                                                    | 
|POLY-3 RATE (b)    |     4/42.20      1/44.33      8/40.05      6/47.85     |                                                    | 
|POLY-3 PERCENT (g) |     9.5%         2.3%         20.0%        12.5%       |                                                    | 
|TERMINAL (d)       |     3/31 (10%)   1/36 (3%)    4/26 (15%)   6/41 (15%)  |                                                    | 
|FIRST INCIDENCE    |     554          731 (T)      577          731 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.241      P=0.145N     P=0.133      P=0.538     |                                                    | 
|POLY 3             |     P=0.183      P=0.164N     P=0.149      P=0.451     |                                                    | 
|POLY 1.5           |     P=0.164      P=0.175N     P=0.151      P=0.417     |                                                    | 
|POLY 6             |     P=0.207      P=0.150N     P=0.146      P=0.493     |                                                    | 
|LOGISTIC REGRESSION|     P=0.160      P=0.177N     P=0.154      P=0.458     |                                                    | 
|COCH-ARM / FISHERS |     P=0.138      P=0.187N     P=0.168      P=0.370     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   6/50 (12%)   1/50 (2%)   |19/50 (38%)  8/49 (16%)   5/49 (10%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     5/41.64      7/45.55      6/40.13      1/47.85     |19/46.66     8/44.51      5/43.41      11/45.63     | 
|POLY-3 PERCENT (g) |     12.0%        15.4%        15.0%        2.1%        |40.7%        18.0%        11.5%        24.1%        | 
|TERMINAL (d)       |     5/31 (16%)   5/36 (14%)   5/27 (19%)   1/41 (2%)   |16/36 (44%)  7/33 (21%)   4/35 (11%)   6/33 (18%)   | 
|FIRST INCIDENCE    |     731 (T)      672          593          731 (T)     |597          675          610          590          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033N*    P=0.495      P=0.409      P=0.051N    |P=0.109N     P=0.022N*    P=0.002N**   P=0.112N     | 
|POLY 3             |     P=0.037N*    P=0.443      P=0.474      P=0.073N    |P=0.072N     P=0.013N*    P<0.001N**   P=0.066N     | 
|POLY 1.5           |     P=0.047N*    P=0.411      P=0.477      P=0.084N    |P=0.073N     P=0.014N*    P<0.001N**   P=0.067N     | 
|POLY 6             |     P=0.027N*    P=0.486      P=0.467      P=0.061N    |P=0.069N     P=0.014N*    P<0.001N**   P=0.064N     | 
|LOGISTIC REGRESSION|     P=0.038N*    P=0.491      P=0.442      P=0.051N    |P=0.089N     P=0.015N*    P=0.002N**   P=0.075N     | 
|COCH-ARM / FISHERS |     P=0.066N     P=0.380      P=0.500      P=0.102N    |P=0.076N     P=0.014N*    P<0.001N**   P=0.063N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  10/50 (20%)  18/50 (36%)  24/50 (48%) |7/50 (14%)   6/49 (12%)   6/49 (12%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     19/42.07     10/45.17     18/40.19     24/47.85    |7/45.91      6/44.29      6/42.98      3/44.30      | 
|POLY-3 PERCENT (g) |     45.2%        22.1%        44.8%        50.2%       |15.3%        13.6%        14.0%        6.8%         | 
|TERMINAL (d)       |     18/31 (58%)  10/36 (28%)  16/27 (59%)  24/41 (59%) |7/36 (19%)   6/33 (18%)   6/35 (17%)   2/33 (6%)    | 
|FIRST INCIDENCE    |     606          731 (T)      645          731 (T)     |735 (T)      735 (T)      735 (T)      697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.213      P=0.008N**   P=0.462      P=0.507N    |P=0.146N     P=0.569N     P=0.522N     P=0.193N     | 
|POLY 3             |     P=0.076      P=0.017N*    P=0.577N     P=0.396     |P=0.138N     P=0.528N     P=0.551N     P=0.172N     | 
|POLY 1.5           |     P=0.061      P=0.025N*    P=0.560N     P=0.309     |P=0.135N     P=0.527N     P=0.543N     P=0.169N     | 
|POLY 6             |     P=0.100      P=0.010N*    P=0.587      P=0.513     |P=0.141N     P=0.532N     P=0.553N     P=0.175N     | 
|LOGISTIC REGRESSION|     P=0.209      P=0.007N**   P=0.528      P=0.494N    |P=0.141N     P=0.569N     P=0.522N     P=0.183N     | 
|COCH-ARM / FISHERS |     P=0.047 *    P=0.038N*    P=0.500N     P=0.210     |P=0.125N     P=0.516N     P=0.516N     P=0.159N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    2/49 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.15      0/45.17      0/39.67      1/47.85     |1/45.91      2/44.82      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         2.1%        |2.2%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    1/41 (2%)   |1/36 (3%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     577          ---          ---          731 (T)     |735 (T)      597          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.621      P=0.487N     P=0.509N     P=0.720N    |P=0.199N     P=0.484      P=0.506N     P=0.517N     | 
|POLY 3             |     P=0.604      P=0.486N     P=0.512N     P=0.731N    |P=0.195N     P=0.492      P=0.513N     P=0.508N     | 
|POLY 1.5           |     P=0.601      P=0.493N     P=0.509N     P=0.744N    |P=0.193N     P=0.490      P=0.511N     P=0.506N     | 
|POLY 6             |     P=0.608      P=0.478N     P=0.517N     P=0.716N    |P=0.196N     P=0.493      P=0.514N     P=0.510N     | 
|LOGISTIC REGRESSION|     P=0.578      P=0.480N     P=0.448N     P=0.687     |P=0.182N     P=0.510      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.188N     P=0.492      P=0.505N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.64      2/45.17      0/39.67      0/47.85     |0/45.91      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    2/36 (6%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          731 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.363N     P=0.272      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.370N     P=0.256      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.387N     P=0.246      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.348N     P=0.268      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.272      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.64      3/45.25      0/39.67      0/47.85     |0/45.91      0/44.73      0/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         6.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    2/36 (6%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          710          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.269N     P=0.152      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.266N     P=0.134      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.286N     P=0.126      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.241N     P=0.145      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.271N     P=0.149      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.311N     P=0.121      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   10/50 (20%)  4/50 (8%)    6/50 (12%)  |5/50 (10%)   8/49 (16%)   3/49 (6%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     5/42.66      10/46.44     4/40.17      6/48.53     |5/46.09      8/46.16      3/42.98      6/44.88      | 
|POLY-3 PERCENT (g) |     11.7%        21.5%        10.0%        12.4%       |10.9%        17.3%        7.0%         13.4%        | 
|TERMINAL (d)       |     2/31 (7%)    6/36 (17%)   3/27 (11%)   5/41 (12%)  |4/36 (11%)   2/33 (6%)    3/35 (9%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     499          404          577          499         |690          620          735 (T)      634          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.315N     P=0.219      P=0.570N     P=0.592N    |P=0.546      P=0.250      P=0.375N     P=0.451      | 
|POLY 3             |     P=0.369N     P=0.170      P=0.538N     P=0.589     |P=0.554N     P=0.276      P=0.395N     P=0.481      | 
|POLY 1.5           |     P=0.407N     P=0.150      P=0.528N     P=0.553     |P=0.547N     P=0.271      P=0.389N     P=0.485      | 
|POLY 6             |     P=0.326N     P=0.197      P=0.553N     P=0.619N    |P=0.558N     P=0.283      P=0.398N     P=0.479      | 
|LOGISTIC REGRESSION|     P=0.465N     P=0.124      P=0.511N     P=0.378     |P=0.536N     P=0.261      P=0.389N     P=0.481      | 
|COCH-ARM / FISHERS |     P=0.456N     P=0.131      P=0.500N     P=0.500     |P=0.527N     P=0.264      P=0.369N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    5/50 (10%)  |1/50 (2%)    0/49 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/41.64      2/45.17      1/39.67      5/47.85     |1/45.91      0/44.73      0/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     4.8%         4.4%         2.5%         10.5%       |2.2%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     2/31 (7%)    2/36 (6%)    1/27 (4%)    5/41 (12%)  |1/36 (3%)    0/33 (0%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     731 (T)      731 (T)      731 (T)      731 (T)     |735 (T)      ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187      P=0.641N     P=0.549N     P=0.341     |P=0.582      P=0.517N     P=0.506N     P=0.742      | 
|POLY 3             |     P=0.134      P=0.665N     P=0.517N     P=0.277     |P=0.589      P=0.505N     P=0.513N     P=0.752      | 
|POLY 1.5           |     P=0.125      P=0.679N     P=0.513N     P=0.251     |P=0.590      P=0.504N     P=0.511N     P=0.754      | 
|POLY 6             |     P=0.147      P=0.646N     P=0.523N     P=0.311     |P=0.588      P=0.507N     P=0.514N     P=0.749      | 
|LOGISTIC REGRESSION|     P=0.187      P=0.641N     P=0.549N     P=0.341     |P=0.582      (e)          (e)          P=0.742      | 
|COCH-ARM / FISHERS |     P=0.114      P=0.691N     P=0.500N     P=0.218     |P=0.595      P=0.505N     P=0.505N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/42.44      0/45.17      0/39.67      0/47.85     |1/45.91      0/44.73      0/42.98      2/45.50      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         0.0%        |2.2%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |1/36 (3%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     429          ---          ---          ---         |735 (T)      ---          ---          172          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.306N     P=0.508N     P=0.508N     P=0.500N    |P=0.240      P=0.517N     P=0.506N     P=0.485      | 
|POLY 3             |     P=0.325N     P=0.488N     P=0.513N     P=0.476N    |P=0.245      P=0.505N     P=0.513N     P=0.497      | 
|POLY 1.5           |     P=0.318N     P=0.494N     P=0.510N     P=0.486N    |P=0.246      P=0.504N     P=0.511N     P=0.498      | 
|POLY 6             |     P=0.334N     P=0.479N     P=0.518N     P=0.463N    |P=0.246      P=0.507N     P=0.514N     P=0.495      | 
|LOGISTIC REGRESSION|     P=0.291N     P=0.360N     P=0.316N     (e)         |P=0.407      (e)          (e)          P=0.742      | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.247      P=0.505N     P=0.505N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/42.48      1/45.36      1/39.87      0/47.85     |0/45.91      0/44.73      2/44.16      1/44.16      | 
|POLY-3 PERCENT (g) |     7.1%         2.2%         2.5%         0.0%        |0.0%         0.0%         4.5%         2.3%         | 
|TERMINAL (d)       |     1/31 (3%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     554          682          677          ---         |---          ---          459          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.059N     P=0.254N     P=0.333N     P=0.086N    |P=0.236      (e)          P=0.228      P=0.483      | 
|POLY 3             |     P=0.068N     P=0.282N     P=0.328N     P=0.099N    |P=0.233      (e)          P=0.229      P=0.492      | 
|POLY 1.5           |     P=0.070N     P=0.294N     P=0.322N     P=0.107N    |P=0.237      (e)          P=0.228      P=0.494      | 
|POLY 6             |     P=0.066N     P=0.268N     P=0.337N     P=0.090N    |P=0.229      (e)          P=0.231      P=0.490      | 
|LOGISTIC REGRESSION|     P=0.076N     P=0.315N     P=0.293N     P=0.189N    |P=0.268      (e)          P=0.372      P=0.483      | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.309N     P=0.309N     P=0.121N    |P=0.246      (e)          P=0.242      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.64      2/45.36      3/40.44      0/47.85     |0/45.91      2/45.34      1/43.73      1/44.19      | 
|POLY-3 PERCENT (g) |     2.4%         4.4%         7.4%         0.0%        |0.0%         4.4%         2.3%         2.3%         | 
|TERMINAL (d)       |     1/31 (3%)    1/36 (3%)    1/27 (4%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     731 (T)      682          583          ---         |---          626          459          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.274N     P=0.560      P=0.281      P=0.444N    |P=0.484      P=0.232      P=0.492      P=0.483      | 
|POLY 3             |     P=0.279N     P=0.530      P=0.294      P=0.472N    |P=0.481      P=0.234      P=0.490      P=0.492      | 
|POLY 1.5           |     P=0.302N     P=0.515      P=0.295      P=0.484N    |P=0.486      P=0.234      P=0.491      P=0.494      | 
|POLY 6             |     P=0.252N     P=0.549      P=0.293      P=0.458N    |P=0.476      P=0.234      P=0.491      P=0.490      | 
|LOGISTIC REGRESSION|     P=0.338N     P=0.539      P=0.300      (e)         |P=0.535      P=0.262      P=0.731      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.337N     P=0.500      P=0.309      P=0.500N    |P=0.500      P=0.247      P=0.495      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/42.48      3/45.54      3/40.44      1/47.85     |0/45.91      2/45.34      2/44.16      0/44.16      | 
|POLY-3 PERCENT (g) |     7.1%         6.6%         7.4%         2.1%        |0.0%         4.4%         4.5%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    1/36 (3%)    1/27 (4%)    1/41 (2%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     554          682          583          731 (T)     |---          626          459          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.165N     P=0.581N     P=0.630      P=0.227N    |P=0.517N     P=0.232      P=0.228      (e)          | 
|POLY 3             |     P=0.186N     P=0.630N     P=0.640      P=0.264N    |P=0.519N     P=0.234      P=0.229      (e)          | 
|POLY 1.5           |     P=0.200N     P=0.647N     P=0.644      P=0.281N    |P=0.514N     P=0.234      P=0.228      (e)          | 
|POLY 6             |     P=0.170N     P=0.609N     P=0.633      P=0.245N    |P=0.524N     P=0.234      P=0.231      (e)          | 
|LOGISTIC REGRESSION|     P=0.234N     P=0.652      P=0.648N     P=0.400N    |P=0.453N     P=0.262      P=0.372      (e)          | 
|COCH-ARM / FISHERS |     P=0.221N     P=0.661N     P=0.661N     P=0.309N    |P=0.500N     P=0.247      P=0.242      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.48      1/45.36      0/39.67      0/47.85     |0/45.91      0/44.73      2/44.16      0/44.16      | 
|POLY-3 PERCENT (g) |     4.7%         2.2%         0.0%         0.0%        |0.0%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     554          682          ---          ---         |---          ---          459          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.088N     P=0.443N     P=0.248N     P=0.196N    |P=0.585      (e)          P=0.228      (e)          | 
|POLY 3             |     P=0.100N     P=0.477N     P=0.252N     P=0.212N    |P=0.577      (e)          P=0.229      (e)          | 
|POLY 1.5           |     P=0.101N     P=0.489N     P=0.248N     P=0.222N    |P=0.583      (e)          P=0.228      (e)          | 
|POLY 6             |     P=0.100N     P=0.463N     P=0.260N     P=0.200N    |P=0.570      (e)          P=0.231      (e)          | 
|LOGISTIC REGRESSION|     P=0.104N     P=0.505N     P=0.195N     P=0.420N    |P=0.646      (e)          P=0.372      (e)          | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |P=0.594      (e)          P=0.242      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/41.92      2/45.47      0/39.67      1/48.20     |0/45.91      0/44.73      2/43.74      0/44.16      | 
|POLY-3 PERCENT (g) |     4.8%         4.4%         0.0%         2.1%        |0.0%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    1/36 (3%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     655          648          ---          633         |---          ---          459          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.239N     P=0.623N     P=0.258N     P=0.397N    |P=0.584      (e)          P=0.232      (e)          | 
|POLY 3             |     P=0.281N     P=0.664N     P=0.249N     P=0.452N    |P=0.578      (e)          P=0.226      (e)          | 
|POLY 1.5           |     P=0.289N     P=0.679N     P=0.246N     P=0.472N    |P=0.583      (e)          P=0.227      (e)          | 
|POLY 6             |     P=0.271N     P=0.646N     P=0.255N     P=0.427N    |P=0.572      (e)          P=0.227      (e)          | 
|LOGISTIC REGRESSION|     P=0.302N     P=0.693N     P=0.246N     P=0.586N    |P=0.627      (e)          P=0.309      (e)          | 
|COCH-ARM / FISHERS |     P=0.296N     P=0.691N     P=0.247N     P=0.500N    |P=0.594      (e)          P=0.242      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Epithelium                                                                                                   | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/42.92      2/45.94      0/39.67      1/48.06     |0/45.91      0/44.73      0/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     9.3%         4.4%         0.0%         2.1%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     554          593          ---          675         |---          ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.068N     P=0.273N     P=0.078N     P=0.118N    |P=0.192      (e)          (e)          P=0.483      | 
|POLY 3             |     P=0.083N     P=0.306N     P=0.070N     P=0.147N    |P=0.195      (e)          (e)          P=0.492      | 
|POLY 1.5           |     P=0.084N     P=0.322N     P=0.067N     P=0.159N    |P=0.197      (e)          (e)          P=0.494      | 
|POLY 6             |     P=0.081N     P=0.288N     P=0.076N     P=0.133N    |P=0.194      (e)          (e)          P=0.490      | 
|LOGISTIC REGRESSION|     P=0.096N     P=0.348N     P=0.052N     P=0.328N    |(e)          (e)          (e)          P=0.483      | 
|COCH-ARM / FISHERS |     P=0.086N     P=0.339N     P=0.059N     P=0.181N    |P=0.199      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Epithelium                                                                                                   | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.64      0/45.17      0/39.67      1/48.20     |0/45.91      0/44.73      2/43.74      0/44.16      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         2.1%        |0.0%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/36 (0%)    0/27 (0%)    0/41 (0%)   |0/36 (0%)    0/33 (0%)    0/35 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     731 (T)      ---          ---          633         |---          ---          459          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.635      P=0.470N     P=0.528N     P=0.697N    |P=0.584      (e)          P=0.232      (e)          | 
|POLY 3             |     P=0.605      P=0.484N     P=0.510N     P=0.727N    |P=0.578      (e)          P=0.226      (e)          | 
|POLY 1.5           |     P=0.601      P=0.492N     P=0.508N     P=0.741N    |P=0.583      (e)          P=0.227      (e)          | 
|POLY 6             |     P=0.610      P=0.474N     P=0.513N     P=0.708N    |P=0.572      (e)          P=0.227      (e)          | 
|LOGISTIC REGRESSION|     P=0.592      (e)          (e)          P=0.742     |P=0.627      (e)          P=0.309      (e)          | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.594      (e)          P=0.242      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Glands                                                                                                       | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  37/50 (74%)  27/50 (54%)  39/50 (78%) |36/50 (72%)  36/50 (72%)  39/49 (80%)  38/50 (76%)  | 
|POLY-3 RATE (b)    |     34/46.25     37/48.63     27/42.62     39/49.54    |36/47.98     36/46.05     39/45.93     38/47.32     | 
|POLY-3 PERCENT (g) |     73.5%        76.1%        63.4%        78.7%       |75.0%        78.2%        84.9%        80.3%        | 
|TERMINAL (d)       |     23/31 (74%)  26/36 (72%)  20/27 (74%)  33/41 (81%) |28/36 (78%)  29/33 (88%)  31/35 (89%)  28/33 (85%)  | 
|FIRST INCIDENCE    |     499          404          506          499         |526          652          459          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240N     P=0.425N     P=0.316N     P=0.265N    |P=0.191      P=0.356      P=0.256      P=0.231      | 
|POLY 3             |     P=0.363      P=0.479      P=0.198N     P=0.356     |P=0.273      P=0.452      P=0.164      P=0.351      | 
|POLY 1.5           |     P=0.315      P=0.394      P=0.169N     P=0.276     |P=0.272      P=0.491      P=0.182      P=0.355      | 
|POLY 6             |     P=0.423      P=0.593      P=0.253N     P=0.464     |P=0.289      P=0.387      P=0.159      P=0.351      | 
|LOGISTIC REGRESSION|     P=0.424      P=0.378      P=0.150N     P=0.312     |P=0.197      P=0.503      P=0.142      P=0.307      | 
|COCH-ARM / FISHERS |     P=0.260      P=0.330      P=0.109N     P=0.184     |P=0.312      P=0.588N     P=0.259      P=0.410      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     38/50 (76%)  44/49 (90%)  36/50 (72%)  41/50 (82%) |                                                    | 
|POLY-3 RATE (b)    |     38/45.85     44/47.18     36/44.80     41/49.19    |                                                    | 
|POLY-3 PERCENT (g) |     82.9%        93.3%        80.4%        83.4%       |                                                    | 
|TERMINAL (d)       |     28/31 (90%)  33/36 (92%)  23/27 (85%)  34/41 (83%) |                                                    | 
|FIRST INCIDENCE    |     499          591          506          633         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.067N     P=0.565N     P=0.427      P=0.095N    |                                                    | 
|POLY 3             |     P=0.348N     P=0.090      P=0.483N     P=0.589     |                                                    | 
|POLY 1.5           |     P=0.455N     P=0.055      P=0.492N     P=0.463     |                                                    | 
|POLY 6             |     P=0.233N     P=0.192      P=0.470N     P=0.488N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.268N     P=0.125      P=0.537N     P=0.471N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.493      P=0.059      P=0.410N     P=0.312     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    3/50 (6%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/41.64      0/44.33      3/39.81      2/47.94     |                                                    | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         7.5%         4.2%        |                                                    | 
|TERMINAL (d)       |     1/31 (3%)    0/36 (0%)    2/27 (7%)    1/41 (2%)   |                                                    | 
|FIRST INCIDENCE    |     731 (T)      ---          695          709         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.325      P=0.470N     P=0.259      P=0.598     |                                                    | 
|POLY 3             |     P=0.290      P=0.488N     P=0.288      P=0.549     |                                                    | 
|POLY 1.5           |     P=0.272      P=0.496N     P=0.292      P=0.528     |                                                    | 
|POLY 6             |     P=0.312      P=0.477N     P=0.283      P=0.574     |                                                    | 
|LOGISTIC REGRESSION|     P=0.306      (e)          P=0.270      P=0.585     |                                                    | 
|COCH-ARM / FISHERS |     P=0.244      P=0.505N     P=0.309      P=0.500     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   4/49 (8%)    7/50 (14%)   3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     8/44.86      4/46.25      7/41.41      3/48.97     |                                                    | 
|POLY-3 PERCENT (g) |     17.8%        8.7%         16.9%        6.1%        |                                                    | 
|TERMINAL (d)       |     1/31 (3%)    0/36 (0%)    2/27 (7%)    0/41 (0%)   |                                                    | 
|FIRST INCIDENCE    |     499          404          506          499         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.147N     P=0.559N     P=0.070N    |                                                    | 
|POLY 3             |     P=0.099N     P=0.162N     P=0.567N     P=0.074N    |                                                    | 
|POLY 1.5           |     P=0.108N     P=0.175N     P=0.548N     P=0.084N    |                                                    | 
|POLY 6             |     P=0.089N     P=0.147N     P=0.592N     P=0.063N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.199N     P=0.253N     P=0.427N     P=0.579N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.124N     P=0.188N     P=0.500N     P=0.100N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Ectopic Parathyroid Gland                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/44 (5%)    1/45 (2%)    2/46 (4%)    2/43 (5%)   |4/49 (8%)    3/47 (6%)    2/48 (4%)    6/47 (13%)   | 
|POLY-3 RATE (b)    |     2/36.92      1/41.45      2/36.34      2/42.00     |4/45.55      3/42.81      2/41.98      6/42.50      | 
|POLY-3 PERCENT (g) |     5.4%         2.4%         5.5%         4.8%        |8.8%         7.0%         4.8%         14.1%        | 
|TERMINAL (d)       |     1/28 (4%)    1/35 (3%)    2/25 (8%)    2/37 (5%)   |4/36 (11%)   1/32 (3%)    2/34 (6%)    4/31 (13%)   | 
|FIRST INCIDENCE    |     554          731 (T)      731 (T)      731 (T)     |735 (T)      597          735 (T)      536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.595      P=0.444N     P=0.659      P=0.611N    |P=0.206      P=0.550N     P=0.363N     P=0.297      | 
|POLY 3             |     P=0.563      P=0.460N     P=0.689      P=0.647N    |P=0.221      P=0.534N     P=0.375N     P=0.326      | 
|POLY 1.5           |     P=0.545      P=0.476N     P=0.694      P=0.670N    |P=0.224      P=0.533N     P=0.368N     P=0.330      | 
|POLY 6             |     P=0.583      P=0.439N     P=0.681      P=0.619N    |P=0.218      P=0.535N     P=0.379N     P=0.323      | 
|LOGISTIC REGRESSION|     P=0.550      P=0.504N     P=0.691N     P=0.645     |P=0.230      P=0.531N     P=0.363N     P=0.351      | 
|COCH-ARM / FISHERS |     P=0.516      P=0.491N     P=0.675N     P=0.683     |P=0.233      P=0.524N     P=0.349N     P=0.344      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/49 (2%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.64      0/45.17      2/40.27      2/47.85     |0/45.91      1/44.51      2/43.72      1/44.16      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         5.0%         4.2%        |0.0%         2.3%         4.6%         2.3%         | 
|TERMINAL (d)       |     1/31 (3%)    0/36 (0%)    1/27 (4%)    2/41 (5%)   |0/36 (0%)    0/33 (0%)    1/35 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     731 (T)      ---          535          731 (T)     |---          675          470          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309      P=0.470N     P=0.468      P=0.597     |P=0.351      P=0.490      P=0.230      P=0.483      | 
|POLY 3             |     P=0.281      P=0.484N     P=0.488      P=0.548     |P=0.350      P=0.494      P=0.226      P=0.492      | 
|POLY 1.5           |     P=0.267      P=0.492N     P=0.490      P=0.528     |P=0.356      P=0.493      P=0.227      P=0.494      | 
|POLY 6             |     P=0.297      P=0.474N     P=0.485      P=0.573     |P=0.344      P=0.494      P=0.227      P=0.490      | 
|LOGISTIC REGRESSION|     P=0.248      (e)          P=0.502      P=0.597     |P=0.388      P=0.510      P=0.304      P=0.483      | 
|COCH-ARM / FISHERS |     P=0.245      P=0.500N     P=0.500      P=0.500     |P=0.368      P=0.495      P=0.242      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  20/50 (40%)  15/50 (30%)  23/50 (46%) |33/50 (66%)  23/49 (47%)  28/49 (57%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     22/44.11     20/46.43     15/40.85     23/48.66    |33/47.68     23/45.25     28/44.19     21/46.34     | 
|POLY-3 PERCENT (g) |     49.9%        43.1%        36.7%        47.3%       |69.2%        50.8%        63.4%        45.3%        | 
|TERMINAL (d)       |     15/31 (48%)  14/36 (39%)  12/27 (44%)  19/41 (46%) |28/36 (78%)  18/33 (55%)  24/35 (69%)  14/33 (42%)  | 
|FIRST INCIDENCE    |     554          593          577          633         |526          620          613          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.265N     P=0.219N     P=0.216N     P=0.224N    |P=0.067N     P=0.090N     P=0.272N     P=0.049N*    | 
|POLY 3             |     P=0.503N     P=0.329N     P=0.152N     P=0.483N    |P=0.026N*    P=0.049N*    P=0.352N     P=0.013N*    | 
|POLY 1.5           |     P=0.532      P=0.376N     P=0.137N     P=0.556N    |P=0.027N*    P=0.050N     P=0.323N     P=0.014N*    | 
|POLY 6             |     P=0.446N     P=0.276N     P=0.183N     P=0.399N    |P=0.024N*    P=0.050N     P=0.360N     P=0.012N*    | 
|LOGISTIC REGRESSION|     P=0.423N     P=0.320N     P=0.137N     P=0.465N    |P=0.041N*    P=0.046N*    P=0.346N     P=0.018N*    | 
|COCH-ARM / FISHERS |     P=0.461      P=0.420N     P=0.107N     P=0.500     |P=0.028N*    P=0.043N*    P=0.242N     P=0.013N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    3/50 (6%)   |2/50 (4%)    0/49 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.07      2/45.36      2/40.33      3/47.85     |2/45.91      0/44.29      1/42.98      0/44.16      | 
|POLY-3 PERCENT (g) |     4.8%         4.4%         5.0%         6.3%        |4.4%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    1/36 (3%)    1/27 (4%)    3/41 (7%)   |2/36 (6%)    0/33 (0%)    1/35 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     606          682          506          731 (T)     |735 (T)      ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.480      P=0.635N     P=0.665      P=0.616     |P=0.199N     P=0.258N     P=0.510N     P=0.258N     | 
|POLY 3             |     P=0.436      P=0.667N     P=0.679      P=0.558     |P=0.192N     P=0.245N     P=0.523N     P=0.246N     | 
|POLY 1.5           |     P=0.416      P=0.680N     P=0.682      P=0.534     |P=0.190N     P=0.245N     P=0.520N     P=0.244N     | 
|POLY 6             |     P=0.459      P=0.649N     P=0.674      P=0.587     |P=0.192N     P=0.246N     P=0.524N     P=0.249N     | 
|LOGISTIC REGRESSION|     P=0.383      P=0.696      P=0.678N     P=0.532     |P=0.199N     (e)          P=0.510N     (e)          | 
|COCH-ARM / FISHERS |     P=0.387      P=0.691N     P=0.691N     P=0.500     |P=0.188N     P=0.253N     P=0.508N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    2/49 (4%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/41.64      0/45.17      0/39.67      2/47.85     |0/45.91      2/44.51      1/42.98      1/44.16      | 
|POLY-3 PERCENT (g) |     7.2%         0.0%         0.0%         4.2%        |0.0%         4.5%         2.3%         2.3%         | 
|TERMINAL (d)       |     3/31 (10%)   0/36 (0%)    0/27 (0%)    2/41 (5%)   |0/36 (0%)    1/33 (3%)    0/35 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     731 (T)      ---          ---          731 (T)     |---          675          734          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.453N     P=0.096N     P=0.145N     P=0.373N    |P=0.478      P=0.225      P=0.495      P=0.483      | 
|POLY 3             |     P=0.546N     P=0.105N     P=0.127N     P=0.437N    |P=0.483      P=0.230      P=0.487      P=0.492      | 
|POLY 1.5           |     P=0.540N     P=0.112N     P=0.125N     P=0.463N    |P=0.488      P=0.230      P=0.489      P=0.494      | 
|POLY 6             |     P=0.552N     P=0.096N     P=0.130N     P=0.405N    |P=0.477      P=0.230      P=0.486      P=0.490      | 
|LOGISTIC REGRESSION|     P=0.453N     (e)          (e)          P=0.373N    |P=0.489      P=0.233      P=0.493      P=0.483      | 
|COCH-ARM / FISHERS |     P=0.531N     P=0.121N     P=0.121N     P=0.500N    |P=0.502      P=0.242      P=0.495      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    5/50 (10%)   5/49 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |2/45.91      5/45.13      5/42.98      3/44.37      | 
|POLY-3 PERCENT (g) |                                                        |4.4%         11.1%        11.6%        6.8%         | 
|TERMINAL (d)       |                                                        |2/36 (6%)    4/33 (12%)   5/35 (14%)   1/33 (3%)    | 
|FIRST INCIDENCE    |                                                        |735 (T)      620          735 (T)      697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.484      P=0.187      P=0.203      P=0.472      | 
|POLY 3             |                                                        |P=0.490      P=0.209      P=0.190      P=0.484      | 
|POLY 1.5           |                                                        |P=0.497      P=0.210      P=0.194      P=0.488      | 
|POLY 6             |                                                        |P=0.484      P=0.206      P=0.188      P=0.481      | 
|LOGISTIC REGRESSION|                                                        |P=0.490      P=0.206      P=0.203      P=0.476      | 
|COCH-ARM / FISHERS |                                                        |P=0.517      P=0.218      P=0.210      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/29/01                           EXPERIMENT: 56111 TEST: 03                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-CINNAMALDEHYDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     VEHICLE      .312%        .625%        1.25%       |VEHICLE      .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   2/50 (4%)    4/49 (8%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |5/45.91      2/45.04      4/42.98      4/44.16      | 
|POLY-3 PERCENT (g) |                                                        |10.9%        4.4%         9.3%         9.1%         | 
|TERMINAL (d)       |                                                        |5/36 (14%)   1/33 (3%)    3/35 (9%)    4/33 (12%)   | 
|FIRST INCIDENCE    |                                                        |735 (T)      652          734          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.551      P=0.250N     P=0.518N     P=0.555N     | 
|POLY 3             |                                                        |P=0.568      P=0.224N     P=0.541N     P=0.524N     | 
|POLY 1.5           |                                                        |P=0.568N     P=0.224N     P=0.535N     P=0.518N     | 
|POLY 6             |                                                        |P=0.562      P=0.225N     P=0.543N     P=0.532N     | 
|LOGISTIC REGRESSION|                                                        |P=0.559      P=0.231N     P=0.517N     P=0.555N     | 
|COCH-ARM / FISHERS |                                                        |P=0.556N     P=0.218N     P=0.513N     P=0.500N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).